Trustees’ Annual Report for the period
From 01-01-24 To 31-12-24
Charity name: Childhood Cancer Research Trust
Charity registration number: 1196005
Objectives and Activities
| SORP reference | ||
|---|---|---|
| Summary of the purposes of the charity as set out in its governing document |
Para 1.17 | To relieve sickness, and preserve and protect health for the public benefit by providing funding for childhood cancer research projects, primarily in the UK in order to improve outcomes for childhood cancer sufferers by finding safer and more effective treatments at a fast rate. |
| Summary of the main activities in relation to those purposes for the public benefit, in particular, the activities, projects or services identified in the accounts. |
Para 1.17 and 1.19 |
In 2024, the charity supported two main activities aligned with these aims: 1. CCRT RSII Initiative– The charity established this structured initiative focused on exploring the role of residual normal systemic, cellular and molecular dynamics in cancer. The programme provides a systematic framework for generating and recording new knowledge relating to the potential role of natural compounds in securing net health in the context of cancer. 2. Ethical and Regulatory Review– The charity funded a comprehensive strategic review of the ethical, legal and regulatory considerations relevant to the integration of targeted, personalised natural compounds into standard paediatric cancer care. This work is informing the charity’s long-term strategy for progressing towards a new design of clinical trials for integrative treatments, centred on biologically-informed, multi-component, individually- evidenced frameworks — ensuring future activity aligns with best practice, regulatory compliance, and legal standards. |
| Statement confirming whether the trustees have had regard to the guidance issued by the Charity Commission on public benefit |
Para 1.18 | In directing our efforts and resources, the trustees of The Childhood Cancer Research Trust have diligently considered and adhered to the guidance issued by the Charity Commission regarding public benefit. This guidance underscores the importance of ensuring that all charitable activities directly contribute to the public good, in line with our charitable objects. This fiscal year, our commitment to maximizing public benefit was exemplified through the launch of the CCRT RSII Initiative and formulation of a compliant operational framework to support the charity’s strategic progression. Importantly, all funds raised have been allocated directly to the ‘New Knowledge’ creation platform and the ‘Ethical and Regulatory Review’, with no overheads, salaries, or administration costs deducted, ensuring that every penny donated is directly applied to advancing this vital work. The new knowledge generated by the CCRT RSII Initiative this year forms part of the critical foundation the charity needs successfully to pursue its mission and the Charity Commission's expectations for public benefit. |
| Additional information (optional) You may choose to include further statements where relevant about: |
||
| SORP reference | ||
| Policy on grant making | Para 1.38 | |
| Policy on social investment including program related investment |
Para 1.38 | |
| Contribution made by volunteers |
Para 1.38 | |
| Other |
Achievements and Performance
| SORP reference | ||
|---|---|---|
| Summary of the main achievements of the charity, identifying the difference the charity’s work has made to the circumstances of its beneficiaries and any wider benefits to society as a whole. |
Para 1.20 | In 2024, the charity set up the CCRT RSII initiative which is focused on the dynamics of normal health retained in the context of cancer. The initiative provides a framework for systematically generating and capturing new knowledge on the potential role of natural compounds in individualized cancer care. While this investigative and exploratory RSII Initiative is designed to build a rigorous basis to facilitate the identification of future research remits and new trial designs, the ethical and regulatory review has clarified the requirements for safely and responsibly translating research into potential clinical applications. In support of these endeavours, the Childhood Cancer Research Trust formed a Board of Consultants who are invited to inform our initiatives with their insights and opinions on an ongoing basis. We have selected high level professionals who are grounded in their knowledge and have experience of working with complexity and evolving landscapes while adhering to the highest possible standards of professional practice. Together, these achievements contribute to the ongoing strategic objective of transitioning new knowledge from the analysis phase, via clinical trials into clinical practice, with the potential to enhance treatment efficacy and reduce side effects associated with conventional cancer therapies. Our efforts aim to fulfil our mission to improve health outcomes for children with cancer and contribute to the broader societal goal of developing safer, more effective therapeutic approaches. |
Additional information (optional) You may choose to include further statements where relevant about:
| Achievements against objectives set |
Para 1.41 | |
|---|---|---|
| Performance of fundraising |
| activities against objectives set |
Para 1.41 | |
|---|---|---|
| Investment performance against objectives |
Para 1.41 | |
| Other |
Financial Review
| Financial Review | ||
|---|---|---|
| Review of the charity’s financial position at the end of the period |
Para 1.21 | The Childhood Cancer Research Trust concluded the fiscal year with limited funds in our account following the successful disbursement of funds for the CCRT RSII Initiative and Ethical and Regulatory review that have resulted in the creation of further core and substantial areas of new knowledge. This aligns with our strategic commitment to advancing medical research and demonstrates effective use of donor contributions for designated purposes. |
| Statement explaining the policy for holding reserves stating why they are held |
Para 1.22 | Reserve Policy Statement Our charity maintains minimal reserves. In the previous fiscal year, we allocated £40,000 to The Concorde Initiative. This disbursement successfully funded the completion of Phase 1 of a critical investment designed to generate new knowledge in pediatric cancer research. The success of this phase marks a significant step towards achieving breakthroughs that could ultimately benefit children suffering from cancer. We aim to allocate funds as quickly as possible to the creation of new knowledge which is urgently needed. |
| Amount of reserves held | Para 1.22 | Minimal |
| Reasons for holding zero reserves |
Para 1.22 | n/a |
| Details of fund materially in deficit |
Para 1.24 | n/a |
| Explanation of any uncertainties about the charity continuing as a going concern |
Para 1.23 | n/a |
Additional information (optional)
You may choose to include further statements where relevant about:
The charity’s principal sources of funds (including any fundraising) |
Para 1.47 |
|
|---|---|---|
| Investment policy and objectives including any social investment policy adopted |
Para 1.46 | |
| A description of the principal risks facing the charity |
Para 1.46 |
Other
Structure, Governance and Management
| Description of charity’s trusts: |
||
|---|---|---|
| Type of governing document (trust deed, royal charter) |
Para 1.25 | Constitution of a Charitable Incorporated Organisation |
| How is the charity constituted? (e.g unincorporated association, CIO) |
Para 1.25 | CIO |
| Trustee selection methods including details of any constitutional provisions e.g. election to post or name of any person or body entitled to appoint one or more trustees |
Para 1.25 | Constitutional Provisions According to our constitution, trustees are selected through a comprehensive evaluation process that assesses each candidate's alignment with our foundational goals and strategic needs. Candidates are reviewed based on their: Commitment to our cause: Demonstrating a passion for advancing medical research and improving healthcare outcomes. Innovative thinking: Ability to contribute new ideas and approaches for transforming medical research and patient care. Medical or NHS background: Although not mandatory, experience in healthcare sectors is considered a significant asset. Diversity of experience: Bringing varied professional and personal backgrounds to provide a wide range of viewpoints and expertise. The selection process is carried out by existing trustees with advice sought from our Board of Consultants as necessary. The final appointment of trustees is made after a majority vote by the existing board members. This process is designed to ensure that our Board of Trustees is equipped with the expertise, vision, and diversity required to guide our charity effectively in its mission. |
Additional information (optional) You may choose to include further statements where relevant about:
Policies and procedures adopted for the induction and training of trustees |
Para 1.51 |
New trustees receive a copy of the current version of the charity’s governing document and the latest Annual Report and statement of accounts. They receive a briefing on the Charity’s objects, grant policy, disclosure requirements and good governance practice. |
|---|---|---|
| The charity’s organisational structure and any wider |
Para 1.51 | The Childhood Cancer Research Trust operates without any staff, focusing on providing grants that support the research initiatives led by Dr Alex Concorde at The |
| network with which the charity works |
Concorde Initiative. Dr Concorde serves as the Medical Director of the charity, leveraging her expertise to take the aims and intentions of the CCRTs R&D policy and map out and create a fleshed-out directive of how the objects can be fulfilled and then manage the enactment of it through TCI. Additionally, supported by our Board of Consultants, the charity’s three trustees oversee the progress of this multiphase initiative, guaranteeing that all efforts directly contribute to fulfilling our charitable aims. This streamlined structure allows for direct and effective use of funds, maximizing impact on paediatric cancer research without the overhead associated with larger organizations. |
|
|---|---|---|
| Relationship with any related parties |
Para 1.51 | The Concorde Initiative, owned by Dr Alex Concorde, is closely linked with the Childhood Cancer Research Trust due to the charity’s focused support of Dr Concorde’s research. Dr Concorde has been appointed Medical Director of the charity in order to spearhead the translation of the CCRT objects into action by mediating between the mission of the CCRT and the actual execution of the charitable objects through her work at TCI, thereby ensuring the research activities align effectively with the strategic goals of the Childhood Cancer Research Trust. The relationship is managed under strict governance practices to avoid any conflicts of interest, ensuring that our collaboration is transparent and maintains the highest integrity. This arrangement enhances our capacity to drive forward innovations in the development of potential treatment and care for children with cancer to a far greater degree than might otherwise be possible. |
| Other |
Reference and Administrative details
| Charity name | Childhood Cancer Research Trust |
|---|---|
| Other name the charity uses | CCRT |
| Registered charitynumber | 1196005 |
| Charity’s principal address | 14 Chester Street |
|---|---|
| Oxford | |
| OX4 1SL | |
Names of the charity trustees who manage the charity
| 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
Trustee name | Office (if any) | Dates acted if not for whole year |
Name of person (or body) entitled to appoint trustee (ifany) |
|---|---|---|---|---|
| Oonah Buist | Chair | |||
| Trina Wright | ||||
| Sarah Lack | ||||
– Corporate trustees names of the directors at the date the report was approved
Director name
Name of trustees holding title to property belonging to the charity
Trustee name Dates acted if not for whole year
Funds held as custodian trustees on behalf of others
Description of the assets held in this capacity
Name and objects of the charity on whose behalf the assets are held and how this falls within the custodian charity’s objects
Details of arrangements for safe custody and segregation of such assets from the charity’s own assets
Additional information (optional)
Names and addresses of advisers (Optional information)
| Names and | addresses of advisers (Optional information) | addresses of advisers (Optional information) |
|---|---|---|
| Type of adviser |
Name Address |
|
| Accounta nt |
Business Control | Red Lion Yard, Odd Down, Bath, Somerset, BA2 2PP, |
Name of chief executive or names of senior staff members (Optional information)
Exemptions from disclosure
Reason for non-disclosure of key personnel details
Other optional information
Declarations
The trustees declare that they have approved the trustees’ report above.
Signed on behalf of the charity’s trustees
Signature(s) Full name(s) Oonah Buist Position (eg Secretary, Chair Chair, etc) Date 30-10-25
Month Of December 2024
Childhood Cancer Research Trust
12
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Description Quarter % Actual Cumulative Proportionate % Actual
Actual Last Year Last Year Actual Last Year /Last Year
Woocommerce Donations 4,113 7,009 58.68% 4,113 7,009 58.68%
PayPal Donations 911 2,351 38.74% 911 2,351 38.74%
Cash Donations 0 379 0.00% 0 379 0.00%
Individual Donations 45,491 50,752 89.63% 45,491 50,752 89.63%
Sales - Others 450 1,453 30.97% 450 1,453 30.97%
Total Revenue 50,964 61,944 82.27% 50,964 61,944 82.27%
Direct Costs
Grants 46,688 40,000 116.72% 46,688 40,000 116.72%
Participant Donation 24,700 0 0.00% 24,700 0 0.00%
Total 71,388 40,000 178.47% 71,388 40,000 178.47%
Contribution Margin -20,423 21,944 -93.07% -20,423 21,944 -93.07%
Contribution Margin % -40.07% 35.43% -40.07% 35.43%
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Quarter % Actual Cumulative % Actual
Description Actual Last Year /Last Year Actual Last Year /Last Year
Salary and Related Costs
Directors Remuneration 0 0 0.00% 0 0 0.00%
Wages & Salaries 0 0 0.00% 0 0 0.00%
National Insurance 0 0 0.00% 0 0 0.00%
Pensions 0 0 0.00% 0 0 0.00%
Benefits 0 0 0.00% 0 0 0.00%
Recruitment 0 0 0.00% 0 0 0.00%
Workwear 0 0 0.00% 0 0 0.00%
Total Salary & Related Costs 0 0 0.00% 0 0 0.00%
Travelling Costs
Car Fuel 0 0 0.00% 0 0 0.00%
Car Maintenance 0 0 0.00% 0 0 0.00%
Road Tax & Insurance 0 0 0.00% 0 0 0.00%
Car Depreciation 0 0 0.00% 0 0 0.00%
Subsistance 0 0 0.00% 0 0 0.00%
Fares 0 0 0.00% 0 0 0.00%
Other Travelling Expenses 0 0 0.00% 0 0 0.00%
Total Travelling Costs 0 0 0.00% 0 0 0.00%
Advertising & PR
Xmas Party 0 1,558 0.00% 0 1,558 0.00%
Advertising - Publications & PR 0 0 0.00% 0 0 0.00%
Events 50 1,224 4.08% 50 1,224 4.08%
Web Related Marketing 0 0 0.00% 0 0 0.00%
Total Advertising & PR 50 2,782 1.80% 50 2,782 1.80%
External and Professional
Legal Fees 0 0 0.00% 0 0 0.00%
Audit Fees 0 0 0.00% 0 0 0.00%
Professional Fees 35 0 0.00% 35 0 0.00%
Accounting Fees 0 0 0.00% 0 0 0.00%
Total External Costs 35 0 0.00% 35 0 0.00%
Facility Costs
Rent 0 0 0.00% 0 0 0.00%
Rates 0 0 0.00% 0 0 0.00%
Insurance - Property & Equipment 0 0 0.00% 0 0 0.00%
Maintenance - Property 0 0 0.00% 0 0 0.00%
Maintenance - Equipment 0 0 0.00% 0 0 0.00%
Utilities 0 0 0.00% 0 0 0.00%
Telecomunications - Office 0 0 0.00% 0 0 0.00%
Telecomunications - Mobile 0 0 0.00% 0 0 0.00%
Equipment Hire & Rentals 0 0 0.00% 0 0 0.00%
Depreciation 0 0 0.00% 0 0 0.00%
Total Facility Costs 0 0 0.00% 0 0 0.00%
General Costs
Stationery 0 0 0.00% 0 0 0.00%
Computer Supplies 0 0 0.00% 0 0 0.00%
Postage 0 5 0.00% 0 5 0.00%
Subscriptions & Donations 0 0 0.00% 0 0 0.00%
Insurance - People 0 0 0.00% 0 0 0.00%
Miscellaneous 0 0 0.00% 0 0 0.00%
Total General Costs 0 5 0.00% 0 5 0.00%
Total Overhead Costs 85 2,787 3.05% 85 2,787 3.05%
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Financing and Miscellaneous Costs
Finance - Charges 70 132 53.22% 70 132 53.22%
Finance - Interest Paid 0 0 0.00% 0 0 0.00%
Finance - Interest Received 0 0 0.00% 0 0 0.00%
Discounts Taken 0 0 0.00% 0 0 0.00%
Loan Costs 0 0 0.00% 0 0 0.00%
Asset Finance Costs 0 0 0.00% 0 0 0.00%
Asset Realisations Costs & Income 0 0 0.00% 0 0 0.00%
Total Financing Costs 70 132 53.22% 70 132 53.22%
PROFIT BEFORE TAXATION -20,578 19,025 -108.17% -20,578 19,025 -108.17%
% TO REVENUE -40.38% 30.71% -40.38% 30.71%
Taxation
Dividends 0 0 0.00% 0 0 0.00%
Tax Provision - Current Year 0 0 0.00% 0 0 0.00%
Total Taxation 0 0 0.00% 0 0 0.00%
PROFIT AFTER TAXATION -20,578 19,025 -108.17% -20,578 19,025 -108.17%
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CHARITY COMMISSION FOR ENGLAND AND WALES Independent examinerfs report on the accounts Section A Independent Examiner'¥ Report Report to the tru•tO0 membgrn of Childhood Cancer Research Trust On •ccount• for the yèar ond•d 3111 DeCamr 2024 Charlty no {If any) 1196005 Sot out on pag08 I report lo the truslees on my examination of the accounts of the above chority {Yhe Tru6t") for the year erKled 3111212024. Re8pon•lbllrtl•8 and bul• of roport As the cherty'6 Iru81ee8. you are re8Fonsible foi the preparation of th8 accounts in acxordance with tho requirements of the Charitie& Act 2011 Iyhe Act.). l Teport in respect of my ex8min81ion of the Twsl'$ 8ccount$ e8rrled oul undor secllon 145 of the 2011 Act and In carylng out my examin8tb)n. I have followed all the applicabfe DIOn8 given by the Charlty Commlg8lon und8r s•cllon 14515llbl of th6 Acl. Indopendent l Am quallfied to undertake the examlnatlon by being a quallfied member of oxamlnorf8 8talomont The Chartered In8titule of Managemenl knounlants. I h8v6 completed nry examination. I confirm that no materfal matters have corrn to my atlenlion In connection whh the ox8mSnalion which gives ma CQU8e to Èelieve that in. any materlal respect: the accounting re¢ord8 were not kept In accordance with 8ectK)n 130 of the Charities Act; or Ihe accounts dKI not accord wlth the accounting record8,' or the accounts not compty wtth the applicabl8 requirements conceming the fomi and conlenl of account¥ $01 out In the Charitio$ (Accounts and Reports) Regulation8 2008 other than any requlrement Ihal the a¢vnI$ gNe a Irue and fairf vwé whlch is not a matter conshJered 88 part of an Independent examinaticrf). I have no concem8 and have Come a¢ro88 no other matters In conne¢llon with the examinatksn lo whKh attenllon shoukl be drawn in thls report In order lo enable 8 proper und8rstandlng of Ihfr accounts to be reached. ' Ple8S dele Ihe woftls in the brackets if they do not 8ppIy. Slgnod: 3 October 2025 N•mo: Rkh ey R•lovant profv¥•lon•l quallllcatlonls) or body Ilf any): A,C.M.A IER Oct 2018
Addross: Red Lw)n Yard, Odd Cvwn BA2 2PP Sectioii B Disclosijie Only complete If the examiner needs lo highlight rnalerial matters of concem (see CC32, Independ8nl examinat ofchatity COunts.. dirEctn5 and guklance for examiner8). Gfvo hor• brf•f detall• of any Items that tho examlner *rfshe8 to dlsclo8•. IER Oct 2018