## **Trustees’ Annual Report for the period** ## **From 01-01-24 To 31-12-24** ## **Charity name: Childhood Cancer Research Trust** ## **Charity registration number: 1196005** ## **Objectives and Activities** ||SORP reference|| |---|---|---| |Summary of the purposes of
the charity as set out in its
governing document|Para 1.17|To relieve sickness, and preserve and
protect health for the public benefit by
providing funding for childhood cancer
research projects, primarily in the UK in
order to improve outcomes for childhood
cancer sufferers by finding safer and more
effective treatments at a fast rate.| |Summary of the main
activities in relation to those
purposes for the public
benefit, in particular, the
activities, projects or
services identified in the
accounts.|Para 1.17 and
1.19|In 2024, the charity supported two main
activities aligned with these aims:
1.
**CCRT RSII Initiative**– The charity
established this structured initiative
focused on exploring the role of
residual normal systemic, cellular
and molecular dynamics in cancer.
The programme provides a
systematic framework for generating
and recording new knowledge
relating to the potential role of
natural compounds in securing net
health in the context of cancer.
2.
**Ethical and Regulatory Review**–
The charity funded a
comprehensive strategic review of
the ethical, legal and regulatory
considerations relevant to the
integration of targeted, personalised
natural compounds into standard
paediatric cancer care.
This work is informing the charity’s
long-term strategy for progressing
towards a new design of clinical
trials for integrative treatments,
centred on biologically-informed,
multi-component, individually-
evidenced frameworks — ensuring
future activity aligns with best
practice, regulatory compliance, and
legal standards.| |||| |---|---|---| |Statement confirming
whether the trustees have
had regard to the guidance
issued by the Charity
Commission on public
benefit|Para 1.18|In directing our efforts and resources, the
trustees of The Childhood Cancer
Research Trust have diligently considered
and adhered to the guidance issued by the
Charity Commission regarding public
benefit. This guidance underscores the
importance of ensuring that all charitable
activities directly contribute to the public
good, in line with our charitable objects.
This fiscal year, our commitment to
maximizing public benefit was exemplified
through the launch of the CCRT RSII
Initiative and formulation of a compliant
operational framework to support the
charity’s strategic progression. Importantly,
all funds raised have been allocated directly
to the ‘New Knowledge’ creation platform
and the ‘Ethical and Regulatory Review’,
with no overheads, salaries, or
administration costs deducted, ensuring
that every penny donated is directly applied
to advancing this vital work.
The new knowledge generated by the
CCRT RSII Initiative this year forms part of
the critical foundation the charity needs
successfully to pursue its mission and the
Charity Commission's expectations for
public benefit.| |**Additional information (optional)**
You may choose to include further statements where relevant about:||| ||SORP reference|| |Policy on grant making|Para 1.38|| |Policy on social investment
including program related
investment|Para 1.38|| |Contribution made by
volunteers|Para 1.38|| |Other||| **Achievements and Performance** ||SORP reference|| |---|---|---| |Summary of the main
achievements of the charity,
identifying the difference the
charity’s work has made to
the circumstances of its
beneficiaries and any wider
benefits to society as a
whole.|Para 1.20|In 2024, the charity set up the CCRT RSII
initiative which is focused on the dynamics
of normal health retained in the context of
cancer.
The initiative provides a framework for
systematically generating and capturing
new knowledge on the potential role of
natural compounds in individualized cancer
care.
While this investigative and exploratory
RSII Initiative is designed to build a
rigorous basis to facilitate the identification
of future research remits and new trial
designs, the ethical and regulatory review
has clarified the requirements for safely
and responsibly translating research into
potential clinical applications.
In support of these endeavours, the
Childhood Cancer Research Trust formed
a Board of Consultants who are invited to
inform our initiatives with their insights and
opinions on an ongoing basis.
We have selected high level professionals
who are grounded in their knowledge and
have experience of working with complexity
and evolving landscapes while adhering to
the highest possible standards of
professional practice.
Together, these achievements contribute to
the ongoing strategic objective of
transitioning new knowledge from the
analysis phase, via clinical trials into clinical
practice, with the potential to enhance
treatment efficacy and reduce side effects
associated with conventional cancer
therapies. Our efforts aim to fulfil our
mission to improve health outcomes for
children with cancer and contribute to the
broader societal goal of developing safer,
more effective therapeutic approaches.| ## **Additional information (optional)** You may choose to include further statements where relevant about: |Achievements against
objectives set|Para 1.41|| |---|---|---| |Performance of fundraising||| |activities against objectives
set|Para 1.41|| |---|---|---| |Investment performance
against objectives|Para 1.41|| |Other||| ## **Financial Review** |**Financial Review**||| |---|---|---| |Review of the charity’s
financial position at the end
of the period|Para 1.21|The Childhood Cancer Research Trust
concluded the fiscal year with limited funds
in our account following the successful
disbursement of funds for the CCRT RSII
Initiative and Ethical and Regulatory review
that have resulted in the creation of further
core and substantial areas of new
knowledge. This aligns with our strategic
commitment to advancing medical research
and demonstrates effective use of donor
contributions for designated purposes.| |Statement explaining the
policy for holding reserves
stating why they are held|Para 1.22|**Reserve Policy Statement**
Our charity maintains minimal reserves.
In the previous fiscal year, we allocated
£40,000 to The Concorde Initiative. This
disbursement successfully funded the
completion of Phase 1 of a critical
investment designed to generate new
knowledge in pediatric cancer research.
The success of this phase marks a
significant step towards achieving
breakthroughs that could ultimately benefit
children suffering from cancer.
We aim to allocate funds as quickly as
possible to the creation of new knowledge
which is urgently needed.| |Amount of reserves held|Para 1.22|Minimal| |Reasons for holding zero
reserves|Para 1.22|n/a| |Details of fund materially in
deficit|Para 1.24|n/a| |Explanation of any
uncertainties about the
charity continuing as a going
concern|Para 1.23|n/a| ## **Additional information (optional)** ## You may choose to include further statements where relevant about: |
The charity’s principal
sources of funds (including
any fundraising)|
Para 1.47|| |---|---|---| |Investment policy and
objectives including any
social investment policy
adopted|Para 1.46|| |A description of the principal
risks facing the charity|Para 1.46|| Other ## **Structure, Governance and Management** |Description of charity’s
trusts:||| |---|---|---| |Type of governing document
(trust deed, royal charter)|Para 1.25|Constitution of a Charitable Incorporated
Organisation| |How is the charity
constituted?
(e.g unincorporated
association, CIO)|Para 1.25|CIO| |Trustee selection methods
including details of any
constitutional provisions e.g.
election to post or name of
any person or body entitled
to appoint one or more
trustees|Para 1.25|Constitutional Provisions
According to our constitution, trustees are
selected through a comprehensive
evaluation process that assesses each
candidate's alignment with our foundational
goals and strategic needs. Candidates are
reviewed based on their:

Commitment to our cause:
Demonstrating a passion for
advancing medical research and
improving healthcare outcomes.

Innovative thinking: Ability to
contribute new ideas and
approaches for transforming
medical research and patient care.

Medical or NHS background:
Although not mandatory, experience
in healthcare sectors is considered
a significant asset.

Diversity of experience: Bringing
varied professional and personal
backgrounds to provide a wide
range of viewpoints and expertise.
The selection process is carried out by
existing trustees with advice sought from
our Board of Consultants as necessary.
The final appointment of trustees is made
after a majority vote by the existing board
members.
This process is designed to ensure that our
Board of Trustees is equipped with the
expertise, vision, and diversity required to
guide our charity effectively in its mission.| ## **Additional information (optional)** You may choose to include further statements where relevant about: |
Policies and procedures
adopted for the induction
and training of trustees|
Para 1.51|
New trustees receive a copy of the current
version of the charity’s governing document
and the latest Annual Report and statement
of accounts. They receive a briefing on the
Charity’s objects, grant policy, disclosure
requirements and good governance
practice.| |---|---|---| |The charity’s organisational
structure and any wider|Para 1.51|The Childhood Cancer Research Trust
operates without any staff, focusing on
providing grants that support the research
initiatives led by Dr Alex Concorde at The| |network with which the
charity works||Concorde Initiative. Dr Concorde serves as
the Medical Director of the charity,
leveraging her expertise to take the aims
and intentions of the CCRTs R&D policy
and map out and create a fleshed-out
directive of how the objects can be fulfilled
and then manage the enactment of it
through TCI.
Additionally, supported by our Board of
Consultants, the charity’s three trustees
oversee the progress of this multiphase
initiative, guaranteeing that all efforts
directly contribute to fulfilling our charitable
aims.
This streamlined structure allows for direct
and effective use of funds, maximizing
impact on paediatric cancer research
without the overhead associated with larger
organizations.| |---|---|---| |Relationship with any
related parties|Para 1.51|The Concorde Initiative, owned by Dr Alex
Concorde, is closely linked with the
Childhood Cancer Research Trust due to
the charity’s focused support of Dr
Concorde’s research. Dr Concorde has
been appointed Medical Director of the
charity in order to spearhead the translation
of the CCRT objects into action by
mediating between the mission of the
CCRT and the actual execution of the
charitable objects through her work at TCI,
thereby ensuring the research activities
align effectively with the strategic goals of
the Childhood Cancer Research Trust.
The relationship is managed under strict
governance practices to avoid any conflicts
of interest, ensuring that our collaboration
is transparent and maintains the highest
integrity. This arrangement enhances our
capacity to drive forward innovations in the
development of potential treatment and
care for children with cancer to a far greater
degree than might otherwise be possible.| |Other||| ## **Reference and Administrative details** |Charity name|Childhood Cancer Research Trust| |---|---| |Other name the charity uses|CCRT| |Registered charitynumber|1196005| |Charity’s principal address|14 Chester Street| |---|---| ||Oxford| ||OX4 1SL| ||| ## **Names of the charity trustees who manage the charity** |1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20|**Trustee name**|**Office (if any)**|**Dates acted if not for whole**
**year**|**Name of person (or body) entitled**
**to appoint trustee (ifany)**| |---|---|---|---|---| ||Oonah Buist|Chair||| ||Trina Wright|||| ||Sarah Lack|||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| |||||| ## – Corporate trustees names of the directors at the date the report was approved ## **Director name** Name of trustees holding title to property belonging to the charity **Trustee name Dates acted if not for whole year** ## **Funds held as custodian trustees on behalf of others** Description of the assets held in this capacity Name and objects of the charity on whose behalf the assets are held and how this falls within the custodian charity’s objects Details of arrangements for safe custody and segregation of such assets from the charity’s own assets ## **Additional information (optional)** ## **Names and addresses of advisers (Optional information)** |**Names and**|**addresses of advisers (Optional information)**|**addresses of advisers (Optional information)**| |---|---|---| |**Type of**
**adviser**|**Name**
**Address**|| |Accounta
nt|Business Control|Red Lion Yard,
Odd Down,
Bath, Somerset,
BA2 2PP,| |||| |||| |||| ## **Name of chief executive or names of senior staff members (Optional information)** ## **Exemptions from disclosure** Reason for non-disclosure of key personnel details ## **Other optional information** ## **Declarations** **The trustees declare that they have approved the trustees’ report above.** **Signed on behalf of the charity’s trustees** **Signature(s) Full name(s)** Oonah Buist **Position (eg Secretary,** Chair **Chair, etc) Date** 30-10-25 Month Of December 2024 Childhood Cancer Research Trust 12 **----- Start of picture text -----**
Description Quarter % Actual Cumulative Proportionate % Actual
Actual Last Year Last Year Actual Last Year /Last Year
Woocommerce Donations 4,113 7,009 58.68% 4,113 7,009 58.68%
PayPal Donations 911 2,351 38.74% 911 2,351 38.74%
Cash Donations 0 379 0.00% 0 379 0.00%
Individual Donations 45,491 50,752 89.63% 45,491 50,752 89.63%
Sales - Others 450 1,453 30.97% 450 1,453 30.97%
Total Revenue 50,964 61,944 82.27% 50,964 61,944 82.27%
Direct Costs
Grants 46,688 40,000 116.72% 46,688 40,000 116.72%
Participant Donation 24,700 0 0.00% 24,700 0 0.00%
Total 71,388 40,000 178.47% 71,388 40,000 178.47%
Contribution Margin -20,423 21,944 -93.07% -20,423 21,944 -93.07%
Contribution Margin % -40.07% 35.43% -40.07% 35.43%
**----- End of picture text -----**
**----- Start of picture text -----**
Quarter % Actual Cumulative % Actual
Description Actual Last Year /Last Year Actual Last Year /Last Year
Salary and Related Costs
Directors Remuneration 0 0 0.00% 0 0 0.00%
Wages & Salaries 0 0 0.00% 0 0 0.00%
National Insurance 0 0 0.00% 0 0 0.00%
Pensions 0 0 0.00% 0 0 0.00%
Benefits 0 0 0.00% 0 0 0.00%
Recruitment 0 0 0.00% 0 0 0.00%
Workwear 0 0 0.00% 0 0 0.00%
Total Salary & Related Costs 0 0 0.00% 0 0 0.00%
Travelling Costs
Car Fuel 0 0 0.00% 0 0 0.00%
Car Maintenance 0 0 0.00% 0 0 0.00%
Road Tax & Insurance 0 0 0.00% 0 0 0.00%
Car Depreciation 0 0 0.00% 0 0 0.00%
Subsistance 0 0 0.00% 0 0 0.00%
Fares 0 0 0.00% 0 0 0.00%
Other Travelling Expenses 0 0 0.00% 0 0 0.00%
Total Travelling Costs 0 0 0.00% 0 0 0.00%
Advertising & PR
Xmas Party 0 1,558 0.00% 0 1,558 0.00%
Advertising - Publications & PR 0 0 0.00% 0 0 0.00%
Events 50 1,224 4.08% 50 1,224 4.08%
Web Related Marketing 0 0 0.00% 0 0 0.00%
Total Advertising & PR 50 2,782 1.80% 50 2,782 1.80%
External and Professional
Legal Fees 0 0 0.00% 0 0 0.00%
Audit Fees 0 0 0.00% 0 0 0.00%
Professional Fees 35 0 0.00% 35 0 0.00%
Accounting Fees 0 0 0.00% 0 0 0.00%
Total External Costs 35 0 0.00% 35 0 0.00%
Facility Costs
Rent 0 0 0.00% 0 0 0.00%
Rates 0 0 0.00% 0 0 0.00%
Insurance - Property & Equipment 0 0 0.00% 0 0 0.00%
Maintenance - Property 0 0 0.00% 0 0 0.00%
Maintenance - Equipment 0 0 0.00% 0 0 0.00%
Utilities 0 0 0.00% 0 0 0.00%
Telecomunications - Office 0 0 0.00% 0 0 0.00%
Telecomunications - Mobile 0 0 0.00% 0 0 0.00%
Equipment Hire & Rentals 0 0 0.00% 0 0 0.00%
Depreciation 0 0 0.00% 0 0 0.00%
Total Facility Costs 0 0 0.00% 0 0 0.00%
General Costs
Stationery 0 0 0.00% 0 0 0.00%
Computer Supplies 0 0 0.00% 0 0 0.00%
Postage 0 5 0.00% 0 5 0.00%
Subscriptions & Donations 0 0 0.00% 0 0 0.00%
Insurance - People 0 0 0.00% 0 0 0.00%
Miscellaneous 0 0 0.00% 0 0 0.00%
Total General Costs 0 5 0.00% 0 5 0.00%
Total Overhead Costs 85 2,787 3.05% 85 2,787 3.05%
**----- End of picture text -----**
**----- Start of picture text -----**
Financing and Miscellaneous Costs
Finance - Charges 70 132 53.22% 70 132 53.22%
Finance - Interest Paid 0 0 0.00% 0 0 0.00%
Finance - Interest Received 0 0 0.00% 0 0 0.00%
Discounts Taken 0 0 0.00% 0 0 0.00%
Loan Costs 0 0 0.00% 0 0 0.00%
Asset Finance Costs 0 0 0.00% 0 0 0.00%
Asset Realisations Costs & Income 0 0 0.00% 0 0 0.00%
Total Financing Costs 70 132 53.22% 70 132 53.22%
PROFIT BEFORE TAXATION -20,578 19,025 -108.17% -20,578 19,025 -108.17%
% TO REVENUE -40.38% 30.71% -40.38% 30.71%
Taxation
Dividends 0 0 0.00% 0 0 0.00%
Tax Provision - Current Year 0 0 0.00% 0 0 0.00%
Total Taxation 0 0 0.00% 0 0 0.00%
PROFIT AFTER TAXATION -20,578 19,025 -108.17% -20,578 19,025 -108.17%
**----- End of picture text -----**
CHARITY COMMISSION FOR ENGLAND AND WALES Independent examinerfs report on the accounts Section A Independent Examiner'¥ Report Report to the tru•tO0 membgrn of Childhood Cancer Research Trust On •ccount• for the yèar ond•d 3111 DeCam￿r 2024 Charlty no {If any) 1196005 Sot out on pag08 I report lo the truslees on my examination of the accounts of the above chority {Yhe Tru6t") for the year erKled 3111212024. Re8pon•lbllrtl•8 and bul• of roport As the cherty'6 Iru81ee8. you are re8Fonsible foi the preparation of th8 accounts in acxordance with tho requirements of the Charitie& Act 2011 Iyhe Act.). l Teport in respect of my ex8min81ion of the Twsl'$ 8ccount$ e8rrled oul undor secllon 145 of the 2011 Act and In carylng out my examin8tb)n. I have followed all the applicabfe DI￿￿On8 given by the Charlty Commlg8lon und8r s•cllon 14515llbl of th6 Acl. Indopendent l Am quallfied to undertake the examlnatlon by being a quallfied member of oxamlnorf8 8talomont The Chartered In8titule of Managemenl knounlants. I h8v6 completed nry examination. I confirm that no materfal matters have corrn to my atlenlion In connection whh the ox8mSnalion which gives ma CQU8e to Èelieve that in. any materlal respect: the accounting re¢ord8 were not kept In accordance with 8ectK)n 130 of the Charities Act; or Ihe accounts dKI not accord wlth the accounting record8,' or the accounts not compty wtth the applicabl8 requirements conceming the fomi and conlenl of account¥ $01 out In the Charitio$ (Accounts and Reports) Regulation8 2008 other than any requlrement Ihal the a¢￿vnI$ gNe a Irue and fairf vwé whlch is not a matter conshJered 88 part of an Independent examinaticrf). I have no concem8 and have Come a¢ro88 no other matters In conne¢llon with the examinatksn lo whKh attenllon shoukl be drawn in thls report In order lo enable 8 proper und8rstandlng of Ihfr accounts to be reached. ' Ple8S dele Ihe woftls in the brackets if they do not 8ppIy. Slgnod: 3￿ October 2025 N•mo: Rkh ey R•lovant profv¥•lon•l quallllcatlonls) or body Ilf any): A,C.M.A IER Oct 2018 Addross: Red Lw)n Yard, Odd Cvwn BA2 2PP Sectioii B Disclosijie Only complete If the examiner needs lo highlight rnalerial matters of concem (see CC32, Independ8nl examinat￿ ofchatity ￿COunts.. dirEct￿￿n5 and guklance for examiner8). Gfvo hor• brf•f detall• of any Items that tho examlner *rfshe8 to dlsclo8•. IER Oct 2018