2023-12-31-accounts

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Trustees’ Annual Report for the period

From 01 January 2023 To 31 December 2023

Charity name: Foundation for Angelman Syndrome Therapeutics UK (FAST UK)

Charity registration number: 1167984

Objectives and Activities

	SORP reference
Summary of the purposes of the charity as set out in its governing document	Para 1.17	The objects of the CIO are:- 1. the advancement of health for the benefit of the pubic by the provision of support towards research into Angelman Syndrome including their treatment and cure, and the publication of the useful results of such research; and 2. the relief of those in need of care, assistance and support as a consequence of living with Angelman Syndrome.
Summary of the main activities in relation to those purposes for the public benefit, in particular, the activities, projects or services identified in the accounts.	Para 1.17 and 1.19	Foundation for Angelman Syndrome Therapeutics UK has been working very hard over the last year to assist Oxford University in the putting together a Natural History Study for Angelman Syndrome. The study is about to start recruiting patients and is fully funded by FAST.
Statement confirming whether the trustees have had regard to the guidance issued by the Charity Commission on public benefit	Para 1.18	The trustees have had regard to the guidance issued by the Charity Commission on public benefit.

Additional information (optional) You may choose to include further statements where relevant about:

SORP reference Para 1.38 Policy on grant making Para 1.38 Policy on social investment including program related investment

Para 1.38 Contribution made by volunteers Other

Achievements and Performance

	SORP reference
Summary of the main achievements of the charity, identifying the difference the charity’s work has made to the circumstances of its beneficiaries and any wider benefits to society as a whole.	Para 1.20	Fund raising activities and donations through-out the financial period have raised income of £267,648. FAST was founded in 2008 with an urgent mission: to cure Angelman syndrome. Today, with operations in the United States, Australia, the UK, Canada, Italy, France, Spain and Latin America, FAST is the largest non-governmental funder of Angelman syndrome research. During 2023, FAST has been continuing to fund the Natural History Study in conjunction with Oxford University. Funding of £495,622 has been provided in the year ended 31 December 2023, being the final amount originally committed to fund the study. In 2024, Foundation for Angelman Syndrome Therapeutics UK has been working hard over the past 4 years in assisting Oxford University in the running of the Natural History Study. The Study has been extended by a further 2 years and will continue to be fully funded by FAST UK. FAST UK continue to liaise with the MHRA and other governing bodies to ensure preparedness for clinical trials in the UK as and when is appropriate.

Additional information (optional) You may choose to include further statements where relevant about:

Achievements against objectives set	Para 1.41

Performance of fundraising activities against objectives set	Para 1.41
Investment performance against objectives	Para 1.41
Other

Financial Review

Financial Review
Review of the charity’s financial position at the end of the period	Para 1.21	At the end of the period the charity was in a net asset position of £189,369.
Statement explaining the policy for holding reserves stating why they are held	Para 1.22	There is no reserves policy, and no reserves are held.
Amount of reserves held	Para 1.22	Nil. Cash at year end was £189,369, none of which is specifically held in reserves.
Reasons for holding zero reserves	Para 1.22	The charity is small and has no fixed costs or expenses, as such no reserves are required. In the current year the charity paid its last instalment of the amounts committed to Oxford University to fund the Natural History Study, no reserves are required to cover this funding liability and the charity has no other liabilities.
Details of fund materially in deficit	Para 1.24	N/A
Explanation of any uncertainties about the charity continuing as a going concern	Para 1.23	There are no uncertainties over the charity’s ability to continue as a going concern.

Additional information (optional)

You may choose to include further statements where relevant about:

The charity’s principal
sources of funds (including	Para 1.47
any fundraising)
Investment policy and
objectives including any	Para 1.46
social investment policy
adopted
A description of the principal	Para 1.46
risks facing the charity
Other

Structure, Governance and Management

Description of charity’s trusts:
Type of governing document (trust deed, royal charter)	Para 1.25	Constitution
How is the charity constituted? (e.g unincorporated association, CIO)	Para 1.25	A Charitable Incorporated Organisation
Trustee selection methods including details of any constitutional provisions e.g. election to post or name of any person or body entitled to appoint one or more trustees	Para 1.25	Apart from the first charity trustees, every trustee must be appointed by a resolution passed at a properly convened meeting of the charity trustees.

Additional information (optional) You may choose to include further statements where relevant about:

Policies and procedures adopted for the induction and training of trustees	Para 1.51
The charity’s organisational structure and any wider network with which the charity works	Para 1.51
Relationship with any related parties	Para 1.51
Other

Reference and Administrative details

Charity name	Foundation for Angelman Syndrome Therapeutics UK
Other name the charity uses	FASTUK
Registered charity number	1167984
Charity’s principal address	13 Inglethorpe Street, London, SW6 6NS

Names of the charity trustees who manage the charity

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20	Trustee name	Office (if any)	Dates acted if not for whole **year **	Name of person (or body) entitled to appoint trustee (ifany)
	Tom Keogh	Chair
	Tamsin Keogh
	Antonia Felix
	Louise Prince
	Julien de Bournet
	Katharine Hamilton
	Irina Karaseva*

*Resigned 6 September 2024

– Corporate trustees names of the directors at the date the report was approved

Director name

Name of trustees holding title to property belonging to the charity

Trustee name Dates acted if not for whole year

Funds held as custodian trustees on behalf of others

Description of the assets N/A held in this capacity Name and objects of the N/A charity on whose behalf the assets are held and how this falls within the custodian charity’s objects Details of arrangements for N/A safe custody and segregation of such assets from the charity’s own assets

Additional information (optional)

Names and addresses of advisers (Optional information)

Type of adviser Name Address	Type of adviser Name Address	Type of adviser Name Address
Name of chief executive or names of senior staff members (Optional information)

Exemptions from disclosure

Reason for non-disclosure of key personnel details

N/A

Other optional information

N/A

Declarations

The trustees declare that they have approved the trustees’ report above.

Signed on behalf of the charity’s trustees

Signature(s) Full name(s) Tom Keogh Position (eg Secretary, Chair Chair, etc) Date 25/10/2024

CHARITY COMMISSION FOR ENGLAND AND WALES Independent examiner's report on the accounts Section A Independent Examiner's Report Report to the trusteesl members of Foundation for Angelman Syndrome Therapeutics UK On accounts for the yoar ended 31 D&cember 2023 Charity no (if any) 1167984 Set out on pages I report to the trustees on my examination of the accounts of the above charity I'the Trust"} for the y8ar 8nd8d 3111212023. Responsibilities and As the charity trustees of the Trusl, you are responsible for the preparation basis of report of the accounts in accordance with the requirements of the Charities Act 2011 ("the Act.). I report in respect of my examination of the Trust's accounts carried out under section 145 of the 2011 Act and in carrying out my examination, I have followed the applicable Directions given by the Charity Commission under seclion 145151(bl of the Act. I have completed my examination. I confimi that no material matters have come to my attention {other than that disclosed below ') in connection with the examination which giv8s me cause to believe that in, any material respect.. accounting records were not kept in accordance with section 130 of the Act or the accounts do not accord with the accounting records Independent examinerfs statement I have no concerns and have come across no other matters in connection with the e,, ention should be drawn in order to enable a proper uni iunts to be reached. Pleas brackets if they do not apply. Signed: Date.. lot Namo: Relevant professional qualification(s) or body (if any): (3006563) Address: JL-LL IER October 2018

Section B Disclosure Only ¢offlplete if the examiner needs to highlight matters of concern (see CC32, Independent exarninalion of charity accounts.. directions and guidance for examiners). Give here brief details of any items that tho examiner wishes to discloso. IER October 2018

	Foundation for Angelman Syndrome Therapeutics UK	Foundation for Angelman Syndrome Therapeutics UK	Foundation for Angelman Syndrome Therapeutics UK	1167984
	Annual accounts for theperiod
	Period start date 01/01/2023		To	Period end date	31/12/2023
Section A	Statement of	financial activities
Recommended categories by activity Incoming resources (Note 3) Income and endowments from: Donations and legacies Charitable activities Other trading activities Investments Separate material item of income Other Resources expended (Note 4) Expenditure on: Raising funds Separate material item of expense Other Net gains/(losses) on investments Extraordinary items Other gains/(losses) Reconciliation of funds: Total Net movement in funds Total funds brought forward Total funds carried forward Total Net income/(expenditure) before investment gains/(losses) Net income/(expenditure) Transfers between funds Other recognised gains/(losses): Gains and losses on revaluation of fixed assets for the charity’s own use		Unrestricted funds Restricted income funds Endowment funds Total funds Prior year funds £ £ £ £ £
		267,648	-	-	267,648	328,007
		-	-	-	-	-
		-	-	-	-	-
		-	-		-	-
		-	-	-	-	-
		-	-	-	-	-
		267,648	-	-	267,648	328,007
		13,076	-	-	13,076	5,544
		-	-	-	-	-
			-	-	-
		13,076	-	-	13,076	5,544
		254,571	-	-	254,571	322,463
		-	-	-	-	-
		254,571	-	-	254,571	322,463
		-	-	-	-	-
		-	-	-	-	-
		-	-	-	-	-
		-	-	-	-	-
		254,571	-	-	254,571	322,463
		65,202 -	-	-	65,202 -	387,665 -
		189,369	-	- 189,369		65,202 -

Section B Balance sheet

Current assets Cash at bank and in hand (Note 9) Total current assets Creditors: amounts falling due within one year (Note 7) Net current assets/(liabilities) Total assets less current liabilities Creditors: amounts falling due after one year (Note 7) Total net assets or liabilities Funds of the Charity Unrestricted funds Total funds Signed by one or two trustees on behalf of all the trustees	Unrestricted funds Restricted income funds Endowment funds Total this year Total last year £ £ £ £ £	Unrestricted funds Restricted income funds Endowment funds Total this year Total last year £ £ £ £ £	Unrestricted funds Restricted income funds Endowment funds Total this year Total last year £ £ £ £ £	Unrestricted funds Restricted income funds Endowment funds Total this year Total last year £ £ £ £ £	Unrestricted funds Restricted income funds Endowment funds Total this year Total last year £ £ £ £ £
	189,369	-	-	189,369	430,360
	189,369	-	-	189,369	430,360
	-	-	-	-	283,348
	189,369	-	-	189,369	147,012
	189,369	-	-	189,369	147,012
	-	-	-	-	212,214
	189,369	-	-	189,369	- 65,202
	189,369		-	189,369	65,202 -
	189,369	-	-	189,369	65,202 -
			Print Name		Date of approval dd/mm/yyyy
			Tom Keogh		21/10/2024
			Katharine Hamilton		21/10/2024

Section C Notes to the accounts

Note 1 Basis of preparation

This section should be completed by all charities .

1.1 Basis of accounting

These accounts have been prepared under the historical cost convention with items recognised at cost or transaction value unless otherwise stated in the relevant note(s) to these accounts.

The accounts have been prepared in accordance with:

• and with*		the Statement of Recommended Practice: Accounting and Reporting by Charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) issued on 16 July 2014
• and with*		the Financial Reporting Standard applicable in the United Kingdom and Republic of Ireland (FRS 102)

• and with the Charities Act 2011.

The charity constitutes a public benefit entity as defined by FRS 102.*



• -Tick as appropriate

1.2 Going concern

If there are material uncertainties related to events or conditions that cast significant doubt on the charity's ability to continue as a going concern, please provide the following details or state "Not applicable", if appropriate:

appropriate:
An explanation as to those factors that support the conclusion that the charity is a going concern;	The charity operates by raising donations and has no fixed costs or liabiliites other than the commitment made to fund Oxford University Natural History Study and there is an agreement in place with a donor to cover any shortfall in general donations to cover this liability. As such there is no uncertainty over the charities ability to contiue as a going concern.
Disclosure of any uncertainties that make the going concern assumption doubtful;	Not Applicable
Where accounts are not prepared on a going concern basis, please disclose this fact together with the basis on which the trustees prepared the accounts and the reason why the charity is not regarded as a going concern.	Not Applicable

1.3 Change of accounting policy

The accounts present a true and fair view and the accounting policies adopted are those outlined in note 2.

Yes*		* -Tick as appropriate
No*

Please disclose:

Please disclose:
(i) the nature of the change in accounting policy;	Not Applicable
(ii) the reasons why applying the new accounting policy provides more reliable and more relevant information; and	Not Applicable
(iii) the amount of the adjustment for each line affected in the current period, each prior period presented and the aggregate amount of the adjustment relating to periods before those presented, 3.44 FRS 102 SORP.	Not Applicable

1.4 Changes to accounting estimates

No changes to accounting estimates have occurred in the reporting period (3.46 FRS 102 SORP).

Yes*		* -Tick as appropriate
No*

Please disclose:

Please disclose:
(i) the nature of any changes;	Not Applicable
(ii) the effect of the change on income and expense or assets and liabilities for the current period; and	Not Applicable
(iii) where practicable, the effect of the change in one or more future periods.	Not Applicable

1.5 Material prior year errors

No material prior year error have been identified in the reporting period (3.47 FRS 102 SORP).

Yes*		* -Tick as appropriate	* -Tick as appropriate
No*
Please disclose:
(i) the nature of the prior period error;			Not Applicable
(ii) for each prior period presented in the accounts, the amount of the correction for each account line item affected; and			Not Applicable
(iii) the amount of the correction at the beginning of the earliest prior period presented in the accounts.			Not Applicable

Section C Notes to the accounts (cont)

Note 2 Accounting policies

2.1 RECONCILIATION WITH PREVIOUS GENERALLY ACCEPTED ACCOUNTING PRACTICE

Please provide a description of the nature of each change There have been no changes in accounting policy in the current year. in accounting policy

Section C Notes to the accounts (cont)

Note 2 Accounting policies 2.2 INCOME

This standard list of accounting policies has been applied by the charity except for those ticked "No" or "N/a". Where a different or additional policy has been adopted then this is detailed in the box below.

Recognition of income Gifts in kind for use by the charity are included in the SoFA as income from donations when receivable. Donated goods for resale are measured at fair value on initial recognition, which is the expected proceeds from sale less the expected costs of sale, and recognised in 'Income from other trading activities' with the corresponding stock recognised in the balance sheet. On its sale the value of stock is charged against 'Income from other trading activities' and the proceeds from sale are also recognised as 'Income from other trading activities'. Goods donated for on-going use by the charity are recognised as tangible fixed assets and included in the SoFA as incoming resources when receivable. These are included in the Statement of Financial Activities (SoFA) when: • the charity becomes entitled to the resources; · it is more likely than not that the trustees will receive the resources; and • the monetary value can be measured with sufficient reliability. Donated goods Contractual income and performance related grants Offsetting There has been no offsetting of assets and liabilities, or income and expenses, unless required or permitted by the FRS 102 SORP or FRS 102. Grants and donations Grants and donations are only included in the SoFA when the general income recognition criteria are met (5.10 to 5.12 FRS102 SORP). This is only included in the SoFA once the charity has provided the related goods or services or met the performance related conditions. Donated goods are measured at fair value (the amount for which the asset could be exchanged) unless impractical to do so. In the case of performance related grants, income must only be recognised to the extent that the charity has provided the specified goods or services as entitlement to the grant only occurs when the performance related conditions are met (5.16 FRS 102 SORP). Legacies Legacies are included in the SOFA when receipt is probable, that is, when there has been grant of probate, the executors have established that there are sufficient assets in the estate and any conditions attached to the legacy are either within the control of the charity or have been met. Government grants The charity has received government grants in the reporting period Tax reclaims on donations and gifts Gift Aid receivable is included in income when there is a valid declaration from the donor. Any Gift Aid amount recovered on a donation is considered to be part of that gift and is treated as an addition to the same fund as the initial donation unless the donor or the terms of the appeal have specified otherwise. Donated services and facilities that are consumed immediately are recognised as income with an equivalent amount recognised as an expense under the appropriate heading in the SOFA. The cost of any stock of goods donated for distribution to beneficiaries is deemed to be the fair value of those gifts at the time of their receipt and they are recognised on receipt. In the reporting period in which the stocks are distributed, they are recognised as an expense at the carrying amount of the stocks at distribution. Donated services and facilities Donated services and facilities are included in the SOFA when received at the value of the gift to the charity provided the value of the gift can be measured reliably.	Yes No N/a	Yes No N/a	Yes No N/a
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Settlement of insurance claims Insurance claims are only included in the SoFA when the general income recognition criteria are met (5.10 to 5.12 FRS102 SORP) and are included as an item of other income in the SoFA. Support costs The charity has incurred expenditure on support costs. Volunteer help The value of any voluntary help received is not included in the accounts but is described in the trustees’ annual report. Redundancy cost The charity made no redundancy payments during the reporting period. Deferred income No material item of deferred income has been included in the accounts. Creditors The charity has creditors which are measured at settlement amounts less any trade discounts Provisions for liabilities A liability is measured on recognition at its historical cost and then subsequently measured at the best estimate of the amount required to settle the obligation at the reporting date This includes any realised or unrealised gains or losses on the sale of investments and any gain or loss resulting from revaluing investments to market value at the end of the year. Income from interest, royalties and dividends This is included in the accounts when receipt is probable and the amount receivable can be measured reliably. Income from membership subscriptions Membership subscriptions received in the nature of a gift are recognised in Donations and Legacies. Membership subscriptions which gives a member the right to buy services or other benefits are recognised as income earned from the provision of goods and services as income from charitable activities. 2.3 EXPENDITURE AND LIABILITIES Liability recognition Liabilities are recognised where it is more likely than not that there is a legal or constructive obligation committing the charity to pay out resources and the amount of the obligation can be measured with reasonable certainty. Investment gains and losses The charity accounts for basic financial instruments on initial recognition as per paragraph 11.7 FRS102 SORP. Subsequent measurement is as per paragraphs 11.17 to 11.19, FRS102 SORP. Governance and support costs Support costs have been allocated between governance costs and other support. Governance costs comprise all costs involving public accountability of the charity and its compliance with regulation and good practice. Support costs include central functions and have been allocated to activity cost categories on a basis consistent with the use of resources, eg allocating property costs by floor areas, or per capita, staff costs by the time spent and other costs by their usage. Grants with performance conditions Where the charity gives a grant with conditions for its payment being a specific level of service or output to be provided, such grants are only recognised in the SoFA once the recipient of the grant has provided the specified service or output. Grants payable without performance conditions Where there are no conditions attaching to the grant that enables the donor charity to realistically avoid the commitment, a liability for the full funding obligation must be recognised. Basic financial instruments	Yes No N/a	Yes No N/a	Yes No N/a
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2.4 ASSETS

Tangible fixed assets for These are capitalised if they can be used for more than one year, and cost at least use by charity

Intangible fixed assets Heritage assets They are valued at cost. The charity has intangible fixed assets, that is, non-monetary assets that do not have physical substance but are identifiable and are controlled by the charity through custody or legal rights. The amortisation rates and methods used are disclosed in note 9.5 They are valued at cost. The charity has heritage assets, that is, non-monetary assets with historic, artistic, scientific, technological, geophysical or environmental qualities that are held and maintained principally for their contribution to knowledge and culture. The depreciation rates and methods used as disclosed in note 9.6.1.4. The depreciation rates and methods used are disclosed in note 9.2. They are valued at cost. Investments Fixed asset investments in quoted shares, traded bonds and similar investments are valued at initially at cost and subsequently at fair value (their market value) at the year end. The same treatment is applied to unlisted investments unless fair value cannot be measured reliably in which case it is measured at cost less impairment. Investments held for resale or pending their sale and cash and cash equivalents with a maturity date of less than 1 year are treated as current asset investments Stocks and work in progress Stocks held for sale as part of non-charitable trade are measured at the lower or cost or net realisable value. Goods or services provided as part of a charitable activity are measured at net realisable value based on the service potential provided by items of stock. Work in progress is valued at cost less any foreseeable loss that is likely to occur on the contract. Debtors Debtors (including trade debtors and loans receivable) are measured on initial recognition at settlement amount after any trade discounts or amount advanced by the charity. Subsequently, they are measured at the cash or other consideration expected to be received. Current asset investments The charity has has investments which it holds for resale or pending their sale and cash and cash equivalents with a maturity date less than one year. These include cash on deposit and cash equivalents with a maturity date of less than one year held for investment purposes rather than to meet short term cash commitments as they fall due. They are valued at fair value except where they qualify as basic financial instruments.	Intangible fixed assets Heritage assets They are valued at cost. The charity has intangible fixed assets, that is, non-monetary assets that do not have physical substance but are identifiable and are controlled by the charity through custody or legal rights. The amortisation rates and methods used are disclosed in note 9.5 They are valued at cost. The charity has heritage assets, that is, non-monetary assets with historic, artistic, scientific, technological, geophysical or environmental qualities that are held and maintained principally for their contribution to knowledge and culture. The depreciation rates and methods used as disclosed in note 9.6.1.4. The depreciation rates and methods used are disclosed in note 9.2. They are valued at cost. Investments Fixed asset investments in quoted shares, traded bonds and similar investments are valued at initially at cost and subsequently at fair value (their market value) at the year end. The same treatment is applied to unlisted investments unless fair value cannot be measured reliably in which case it is measured at cost less impairment. Investments held for resale or pending their sale and cash and cash equivalents with a maturity date of less than 1 year are treated as current asset investments Stocks and work in progress Stocks held for sale as part of non-charitable trade are measured at the lower or cost or net realisable value. Goods or services provided as part of a charitable activity are measured at net realisable value based on the service potential provided by items of stock. Work in progress is valued at cost less any foreseeable loss that is likely to occur on the contract. Debtors Debtors (including trade debtors and loans receivable) are measured on initial recognition at settlement amount after any trade discounts or amount advanced by the charity. Subsequently, they are measured at the cash or other consideration expected to be received. Current asset investments The charity has has investments which it holds for resale or pending their sale and cash and cash equivalents with a maturity date less than one year. These include cash on deposit and cash equivalents with a maturity date of less than one year held for investment purposes rather than to meet short term cash commitments as they fall due. They are valued at fair value except where they qualify as basic financial instruments.	Yes No N/a	Yes No N/a	Yes No N/a
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POLICIES ADOPTED ADDITIONAL TO OR DIFFERENT FROM THOSE ABOVE	Not Applicable

Section C Notes to the accounts (cont)

Note 3 Analysis of income

Note 3 Analysis of income	Analysis of income	Analysis of income	Analysis of income	Analysis of income	Analysis of income	Analysis of income
Unrestricted funds Restricted income funds Endowment funds Total funds Prior year £ £ Donations andgifts 267,648 - - 267,648 328,007 - - - - - Total 267,648 - - 267,648 328,007 - - - - - - - - - - - - - - - Total - - - - - 267,648 - - 267,648 328,007 Other information: Analysis Donations and legacies: Charitable activities: TOTAL INCOME	Unrestricted funds Restricted income funds Endowment funds Total funds Prior year £ £ Analysis
	Donations andgifts	267,648	-	-	267,648	328,007
		-	-	-	-	-
	Total	267,648	-	-	267,648	328,007
		-	-	-	-	-
		-	-	-	-	-
		-	-	-	-	-
		-	-	-	-	-
		267,648	-	-	267,648	328,007

All income in the prior year was unrestricted except for: (please provide description and amounts)

All income in the current year and prior year was unrestricted. A donation of £212,214 (prior year: £283,388) was received and whilst not restricted, the donation was designated for funding the charity's commitment to fund the Oxford University Natural History Study.

Where any endowment fund is converted into income in the reporting period, please give the reason for the conversion.

Not Applicable

Where any endowment fund is converted into income in the prior period, please give the reason for the conversion.

Within the income items above the following items are material: (please disclose the nature, amount and any prior year amounts)

Not Applicable Material donations have been received in the current and prior year to fund the the Oxford University Natural History Study commitment.

Section C Notes to the accounts (cont)

Note 4 Analysis of expenditure

Analysis Expenditure on raising funds:	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year	Unrestricted funds Restricted income funds Endowment funds Total funds Unrestricted funds Restricted income funds Endowment funds Total funds £ £ This year Last year
Incurred seeking donations	562	-	-	562	562	-	-	562
Staging fundraising events	12,232	-	-	12,232	4,805			4,805
Advertising, marketing, direct mail, publicity and administration	223	-	-	223	177	-	-	177
	-	-	-	-	-	-	-	-
Separate material item of expense Total expenditure on raising funds	13,016	-	-	13,016	5,544	-	-	5,544
	-	-	-	-	-	-	-	-
	-	-	-	-	-	-	-	-
	-	-	-	-	-	-	-	-
TOTAL EXPENDITURE Total	-	-	-	-	-	-	-	-
	13,016	-	-	13,016	5,544	-	-	5,544

Section C Notes to the accounts

Note 5 Details of certain items of expenditure

Fees for examination of the accounts

Other fees (for example: financial advice, consultancy, accountancy services) paid to the independent examiner Independent examiner’s fees Assurance services other than audit or independent examination Tax advisory fees	This year £	Last year £
	-	-
	-	-
	-	-
	-	-

Section C Notes to the accounts (cont)

Note 6 Grantmaking

This year:

6.1 Analysis of grants made

This year: 6.1 Analysis of grants made
Analysis	Grants to institutions	Grants to individuals	Support costs	Total
			£	£
Oxford UniversityNatural HistoryStudy	-	-	-	-
Total	-	-	-	-

6.2 Grants made to institutions

The charity has not made any additional grants in the current year. In the year ended 31 December 2020 the charity made a commitment to fund the Oxford University's Natural History Study of up to £1,077,103. In the current year payments were made under this commitment of £495,622 (prior year: £293,610). At the end of the reporting period the outstanding funding committment was £0 (prior year:£495,652) (see note 7 and note 8). Details of the institution supported, purpose of the grant and total paid to each institution is available on the charity's web site.

https://cureangelman.org.uk/oxford-natural- history study

Names of institution	Purpose	Total amount of grantspaid £
Oxford University	Angelman Syndrome Natural History Study	495,622
TOTAL GRANTS PAID Total grants to institutions in reporting period		495,622
		495,622

Last year:

6.3 Analysis of grants made

Last year: 6.3 Analysis ofgrants made
Analysis	Grants to institutions	Grants to individuals	Support costs £	Total £
Oxford UniversityNatural HistoryStudy	-	-	-	-
Total	-	-	-	-

6.4 Grants made to institutions

My charity has made grants to particular institutions that are material in the context of its grantmaking. Details of the institution supported, purpose of the grant and total paid to each institution is available on the charity's web site.

https://cureangelman.org.uk/oxford-natural- history study

Names of institution	Purpose	Total amount of grantspaid £
Oxford University	Angelman Syndrome Natural History Study	495,622
TOTAL GRANTS PAID Total grants paid to institutions in reporting period		495,622
		495,622

Section C Notes to the accounts (cont)

Note 7 Creditors and accruals

7.1 Analysis of creditors

Accruals for grants payable

Total	Amounts falling due within oneyear	Amounts falling due within oneyear	Amounts falling due after more than oneyear	Amounts falling due after more than oneyear
	This year £	Last year £	This year £	Last year £
	-	283,388	-	212,174
	-	283,388	-	212,174

Section C Notes to the accounts (cont)

Note 8 Reconciliation of funding commitments

8.1 Movements in funding commitment during the period

Balance at the start of the reporting period Amounts added in current period Amounts paid in the current period Balance at the end of the reporting period

This year £	Last year £
495,562	789,172
-	-
- 495,622	- 293,610
- 60	495,562

8.2 Please provide:

8.2 Please provide: - a brief description of any obligations on the balance sheet and the expected amount and timing of resulting payments; - an indication of the uncertainties about the amount or timing of those outflows; and - the amount of any expected reimbursement, stating the amount of any asset that has been recognised for that expected reimbursement. 8.3 Where unrestricted funds have been designated to a fund commitment, please disclose the nature of any amounts designated and the likely timing of that expenditure.	Thisyear Lastyear	Thisyear Lastyear
	The only obligation of the charity relates to the funding commitment made to Oxford University for the Natural History Study. Of the £1,077,103 committed £0 remains due at the end of the reporting period.	The only obligation of the charity relates to the funding commitment made to Oxford University for the Natural History Study. Of the £1,077,103 committed £495,562 remains due at the end of the reporting period. The remaining amount will be paid over the next 2 years, with £283,388 payable in the next year.
	Not Applicable, the payments are to be made in accordance with the budget agreed within the commitment agreement.	Not Applicable, the payments are to be made in accordance with the budget agreed within the commitment agreement.
	No amounts are expected to be reimbursed and no assets have been recongnised in relation to any expected reimbursments.	No amounts are expected to be reimbursed and no assets have been recongnised in relation to any expected reimbursments.
	The charity's only funding commitment relates to the Oxford University Natural History Study. No formal designation of untrestricted funds has been made but it is expected that these amounts will be paid out of unrestricted funds. There were no funding commitments at the end of the reporting period.	The charity's only funding commitment relates to the Oxford University Natural History Study. No formal designation of untrestricted funds has been made but it is expected that these amounts will be paid out of unrestricted funds.

Section C Notes to the accounts (cont)

Note 9 Cash at bank and in hand

Cash at bank and on hand Other Total

This year £	Last year £
189,369	430,360
-	-
189,369	430,360

Section C Notes to the accounts (cont)

Note 10 Events after the end of the reporting period

Please provide details of the nature of the event

Provide an estimate of the financial effect of the event or a statement that such an estimate cannot be made

This year Last year Further payments have been made to fund the Oxford University Natural There were no material events after the History Study in line with the end of the reporting period. commitment made. Payments of £283,388 were made in the after the end of the reporting period but before the accounts were approved. This reduced the funding N/A commitment liability to £212,174.

Section C Notes to the accounts (cont)

Note 11 Transactions with trustees and related parties

11.1 Trustee remuneration and benefits

This year

None of the trustees have been paid any remuneration or received any other benefits from an employment with their charity or a related entity (True or False)

Last year

None of the trustees have been paid any remuneration or received any other benefits from an employment with their charity or a related entity (True or False)

TRUE TRUE

11.2 Trustees' expenses

No trustee expenses have been incurred (True or False)

TRUE

11.3 Transaction(s) with related parties

Please give details of any transaction undertaken by (or on behalf of) the charity in which a related party has a material interest, including where funds have been held as agent for related parties. If there are no such transactions, please enter 'true' in the box provided.

This year

There have been no related party transactions in the reporting period (True or False)

TRUE

In relation to the transactions above, please provide the terms and conditions, including any security and the nature of any payment (consideration) to be provided in settlement. Not Applicable

For any related party, please provide details of any guarantees given or received. Not Applicable

Last year

Last year	Last year
There have been no related party transactions in the reporting period (True or False)		TRUE
For any related party, please provide details of any guarantees given or received. In relation to the transactions above, please provide the terms and conditions, including any security and the nature of any payment (consideration) to be provided in settlement.
	Not Applicable
	Not Applicable. In the previous reporting period one of the trustees together with another individual has agreed to make up any shortfall in funding if the chairty are unable to fund the amounts committed to the Oxford University Natural HistoryStudy.

Section C Notes to the accounts (cont)

Note 12 Additional Disclosures

The following are significant matters which are not covered in other notes and need to be included to provide a proper understanding of the accounts. If there is insufficient room here, please add a separate sheet.

No additional significant matters to note.