2025-03-31-accounts

Re￿s￿*￿ 1158189 KN¢f•iN AS HlSno UK ANI4UAL REpoftfAND UNALIDfiED FINANQAL sfATEMÉIIT5 FOR THE YEAR ENDED 31 AqAR¢H 2Q5

Hisnocyiosis UK H15no UK iEGAL AND AOMINisllIA￿ INFOAMAYION Mr A Kontoyannis. Chalr Pfr)l. P aeveFley Dr V Nandurt Mr P ￿enefi$tOCk Prof. M Collin Dr R fattersall Oth•pOffl￿fS Lynn Jaclson. Executive Olrector Chartty number 1158789 p￿ndpa[ •ddr PO Box 159 Liskeard Q)rnwall pu4 9DQ Ind•wndent emmlnw TC Group 33 805ton Road South Holbeach Spaldin8 UrKolnshlre PE12 7LR B4nk CAF Hank UmSted 25 Ktnp Hlll Avenue Kings. Hill West Malllni Kent ME194JQ

HJSTiocYf051S Lr Hisno UK CON7ENf5 Trn5tee5' report Ststemomt of tnths. ￿spOnSIbl10t1es Independnt eFamlnerfs report Ststement of finanelal arti4ile5 B¥tsnc• sh•ei Notes ta the financral strtements 10-17

HISTiocYfosis UK Hisrio ux TrUSIEES' REPORT FOR THE YEAR EPIDED 31 MAACH2025 The rrustiyes P￿sent thelr •llnual report and ftnanclal statements for the year ended 31 Math 2025. Pml. C Booth on 31st Au8bJSt 2024 Oble¢li¥esand acd¥ltks • The oblert ol ihe CIO Is Ihe reltef cl sickness and preser¥allon ol good h?alih amon8 patlents Jfferted histlorytlc dlseases ihdr families and carets. In particular but fiot exclu51vely by: 111 the prDmotion and further4nce of sclentlllt rtsearth Into the phwlolory and patholoRY ol histloLytes Jnd the JetiDlogy of histiocytoLytlc 015eases. thE Useful fesulrs of which will be dis5emln•ted for the publlc benefit,. lill the devewmeni of more accuTrte means of dia8nosi5. improverj proiocols for managemert of ￿UeNts and ulilmlrely measurÈs foi pre¥enrlon of N5tiWic dlsease5: Iiril the pm¥isSon and dlmeminailon ol Informa￿0￿. edueatron and kn¢Mled&e in support ol Mlents and firnllles aflKted by the disease to include the medlcal profe5slons and 8neral publlr, • Ilv) c¢llaboTrtlon wlih inten15t￿ Individuals •Trd OryanI￿tiOns. The TrLtstees confim that they have ￿leffe￿ to the g￿ldIn(e ¢tsntained in the Charlty Commlsslon'$ 8enerydl 8uidanre on publlG benefft when rev￿wIng the ChaTIty's alrns and objectives and In plannin8 fulut •ctivttle5 and Settl￿ the 8rant poucy forthe year. The Charfty carries oui thvA obled￿S by focusing on these aras Ihrou8h which we 4chkne our strate8iC pdortzies ol mainlAlnlnB a stable ptoirarnmt and the CDntinued fundini of ¥btal researth. The bentllts ol ihe Charity's work are the de¥elopmtnt ol future research. rhe dlssemlnatlon of rrfearch fimdlnKS. the development of ftew therdple5 and the fvndlr¥ of 01tr804nB re5eaich wlth the 8oal belng able to Inlon sufferers. their and lamil¢es. Thp trustees CDnfim that Ihey have complled 7knh the rqutrem•nts of sectlon 17 cf th• Charltl•s Act 2011 have tT8ard to tht publlc benelltguldance pvbltshed by the Chartty COMMIS￿On for E￿14Th￿ and Wales. Flnafvdal Roport The tharIL￿$ paliry * prtsent IS to Sn¥est In Iow-risk ond re450n¥bly Ilquld assets. so that fvnds are av•ille to rntet any unforeseen needs thai may arise, for eyample, as a consequ•nce af rpeetini athltles. As lar as possible. the ChafiVI seeks to follow an ethical investment stftte8y that predudes Inv•$14n8 in any company whose actlvltles fftay have an adverse Irnpatt on the underSylnB ben•fldath of the tharity, Whlle striving for the hl8hest eihlcal srandartls. thE Charity wlll adhe￿ to the Charity COMMI￿on'5 rule th4t wt mamimise the income of the charity withotst exptsstsr¢ to urtduè ris

H15no UK TrusrB' REPOHT {CONTrNUED) Fln4ndol rnbTew The Chaim74Tr rtyularty ￿l￿W5 the rostr¥es of the chority to ensure ih•t suffident Ilquld fvnds a￿ a¥allable ro the Charlty to meet its orwnl obliW5¢x6. The ￿SelVeS throughout the aC￿u￿)￿ perTrod have been adequthto f4tlfll thls oblectlv•. The 20E21)25 Inrome st•ady 48aln# the p￿Qu$ nnanclal ￿ar. charl￿ are In generdl suffeflng fmm the a7ntln¥ed d¢yn￿rn In thE cost ol Ir4fn& ra151￿ onBoin8 concem5 about Ihe "o)st of Ki¥1￿. In th15 economlc cllmats. We thank all ol our 8enero¢Js donor5. the Indlv5dyal4 communlty VDUPS. 5¢hook. corpordte ￿pPorterS, Chities and FoUnda￿an$ that ContInu￿ thelr support and ￿flects the excelleni partkipa￿On, driye and iernslty of tsur c4fflrnuth lundtsh¢￿ supporters, fan4lle5 and t¢Anmitted Individuab tlwt been atAe to us m•lntsln the Chaty. H15tlo UK placed a call for Researth Paper5, after sub5tsntlal ievlew by the Suentlllc Revlew aoaTd and rDnfim41ion of the Boa￿ of TFUSes an awanl offer VAS mide to.. DT Clalre Shannon-Lowe and her team lor a proiert to Undetstsnd ihe rDle of MWold derlvtd supprE55or ceus In the pathoIene5￿ of Epsttln Ba￿ vor￿$. as%Kiat•d HLH. Nll In the financlal year Flnandal R•lknlry on thts p•sr yw of 0￿￿tIOn, we acknowledBe ihe ￿pPOrt reeeived tn kn of funds •nd thq contrfbutlons ol ¢wr VolUrfee￿ Ind Hisilo Clwllplon5. We recognlse t￿t the currnnt eoinomlc climate affffts not only us but also Our MIAio Communlty and olhw5, makln8 It • chall￿￿n8 ￿rIOd for e¥eryfjno. The Charity acknowledaej the Ilkelllwod of fEdu(ed IrK3)me for the futurE and contlftuts to adjust pftctlces and budB•ts aca>rdir41y. We ore very pleased to ha¥E continued and further dewtloped our various HtstFOCVtir infonhatlon guides and 50clal rn￿la platforn￿ 8llowlnK us tt4 tno44 fwther Wilh our Patients, PabTn15 and SupporteB. In o)Habor4tlon with our panner5. * w41 malntslA our commltrnent io pmvxlln8 hlsEiocytic prpIe5￿o￿IS. potlents. and families ith the mort Sntsrniatlon re8ard4n8 these rious and de￿￿$ d150rdef5 as il becomes ovallable. Thank you al.

HISTIOCYFOSIS UK Hisno IJK TrusrEE5' REpoirr Ici)IfflNUED) R)R ThtE VEAR ENDED 31 MAROI 2025 Path•r5hlp5 Hlsuo UK prDiide5 webslte admiftthtive support to this am•iin8 group. Hlstlo UK provides web51te admlni5tTrtlon 10 th15 eA•bli5hed re8lstry pro8rnm. PPPIEPunel-P•Vert Pavert Publl¢lnvahcment a Enqaqemtnrponel Histiotytosts UK Is committed to meaninglitl patlent and publK Itivolvement and publlc enlatement for and on behall of not onty Its own Gftnl Fund Award5 but to appfdlse those of ulher Researchets and or Or¥an1￿tIOnS in the field ol r•searth with prlorlty to tlia5e of H15tlocyti¢ d4se•se5. Ourvi5ion wlih rer4rds to patlnt. par•nt ond pubIk+n￿l¥ernent and en8agement I "to esiablish • culiurn wlthln Hlstio¢ytosls iIK where our commuthty h•$ the 5ktlls Ind resources to optlm15e and dellver patlent and publi¢ Involvoment and enzo&ement and It is inth8rnted In to our of worklnB afid thrDU8hout the rnsearth we lund and app￿15•. Hlstlocyt0515 UK hos, In tonsultation ￿th rn5eiir¢hers, publ1¢ ¢orttrfbuior5 and InbKsl¥tment professionals, ideniffied 6 alms that wlll gvlde HistiOLytOSis UK and Fts •npymtnt proyamme tu work tQ¥Ydrds it's tytsto that No one should die ol HistlQLytOSi5'. Ensure our iesearth comrnunlty ihcorporaies pat￿t and publlc Involvement and enwement throu8hoLrt Trseorch. Intorpornte relwdnt Invofvement thra4haui our fundlw pr￿esses. Lead by exarn￿e In our Invol¥ementand en8aBement pranice. . SirpnKthen i￿1¥¥Ment and enpiement practic of Histyo UK'S PJiinL & Public In¥•hrnenl Eh8a8emÈrtt ￿ne1. Insplre and encour38e Inclusi¥e. Innovatlve. di¥ets• and creall¥ paI￿nt, parent and pub15c Involvement •rtd èn8a8ement. Impn)ve the knowledge sharln8 olpatlent, Pa￿￿t and publlc invol¥ement arvl enptrm•nt. The HS is the oryani5akn repiesenting clinkal and research prOfess￿Ra[$ in the Ileld of Hlstipcyllc d150rdtrs. rh Nlknlos5ymwslumon Hhtltxytasts The Nlkolas Syrnposlum Is the leadln8 Scientif￿ think.tank fuaMd on a 8mup of rnTE d￿a$￿ <alled ￿￿10cVIk dlsorders. This intern•tlonal research symp0￿￿MIS dedicated to foxerini InnmU4t fEs•arch. Awareness Awareness HlstkrytDslJ UK202412025-g•teSk&Lets Tolk& Shqre yourltskr Thi5 year we eKpandeLI our Shar* ￿ur Volce proram kn Incl¥de B6te-Sze efi4bliry HlxiD Proknionab and Patients to share iheirexper6tnce and journey5.

Hisnocyyosis UK Hlsllo UK 7RUs￿E￿ ftEPORr (co￿￿￿VED1 FOR ThEYEARWdDE031 MARCH2025 Phns fBrth• fufvrn Htstlo UK remalns at th• forefront In chalen8ln8 these deV45tsu￿ dlsorfer4 WE wjll cuntlnue to bulld on the transfer of Infvrmakn and knowled8e mllable nt¥onallyand Inttrn•tiorollythmu8h our ojmmiltee strt¥cture to parnts. patients •nd medkal prole5sfionals. StN¢ture, 6ty4ern•fte•4nd M•nayrnent HlstloLfvls UK Is * r•Alrter•d charlty, nwnber 1158789. Ind Is constiiutd as a charttable In￿rP￿rIte0 D￿nIs0t1¢￿ In England 4nd Wales. Th• Ch•riry arti￿[V fundralss and seeks to continue the charitsble wor dos}￿d by tho donol through the ¢arelul #ewanlshlp of Its exl#in8 resDurce At ih• ann￿￿ TTUStees' rneetsnK% the TA￿•5 a8lt th• brnad strath8y and IT￿ of xtivity for the Charity. In¢[Ud5￿ COn￿d•￿tIon of 8rant m•Wn& 5n¥stmenL reseThes and risk manayment pobicies and performan¢¢. The dato4ay admlnlsir4tlon of 8rnnts •nd the p1vc￿l￿8 ond ￿ndI￿n8 of ¥plkntlons prtor to coft$ldeTrllan by the Charfty 55 Jeltyted to the Ex•cutfve Olrertor. Th• thartvs Indpendent Sdentifle Revlew Board consider èll applkatlons against a8roed trlterfa prfor to maklry r•commendation to thE Charfty on fvndln8 8rdnt& The SR8 all oppllotions rttei¥ed In response to calls for proposal& Th• Ch•lr olthESR8 for Z024th1015. ￿￿¢S5Or P¢trr Bwerlty MBBS. ￿ FMedSEL VktrCh•lf . Pffjlu￿ M•tth•w Collln. BM. uch. OPMI, MRCP, gRCPat The Trustee5 regularly rDrfew ihe 5kiHs and comp051tlon of thelr body and conduct surcossion plannln8. Thev rwuft new Trustees based on experlence. •mpathy. and knowled&e ol the ch•rtt% yèar, th Tru5the Board Introduced and O￿labOrat•d whh an elected Ad¥isary Panel. As we mo¥• Into our new finanilal year TN$t￿ will retire at ihe end of iheir term i)f nfflr.p k¥ith th• Charbiy alwa￿ w• twlll take Ihls QPPOrtuntty to I￿th¥ our Gi>vemance structurn and assess the bènefits of utili5in8 any opportuftftles Inay b• from adlysory boarfs allo•AnB 115 to more fumy support the Ext￿tI DirKtor in fvnhcomlni projects and inliiatives and at the same tlme focus on Ouf Stftnnhs. FundratslniRey￿at1t The Cbartty ts re&ste￿d with the Fundra￿￿￿ RewJlator is in lull compliano with sts ￿quireMEnts. T Charfty adhere5 to the key prln¢lpJes and behaVi￿r5 in that the work of its fundrntslng will be lgal, Open, Honstand Respothl. ftlskspanayrnent The Tnjstees h•NY onsldrEd the maJor rl%ks to which the charfty is exposed ènd revÉewed thctst ￿kS and •5tabli5hed Swms and prncedU￿ to marnaBe those rts&& The Trustees con5idervarlabilityof investn*nt retums.

HISTKI UK TRUSTEE5' REPOVIT ia)NlliiuED) FOR THE VEAR ENDED31 MARCH2025 O¥rth•n The Charrty wishes to express ILS ¥rntilude to all Our ¥oluntetrts lor th￿r fifrndiatslrw artfvltfe4 ted￿1￿1 5￿J[[S, and partidpatlon In vfrtual and phyycal eversts that ho¥e tsken place throu8hout c￿ntry in thb dNficuIt VE4r. Our thanks to our Co￿￿at* donots includlng those matth fvnding pr0￿MM￿S ￿thkh our sup er5 'th the. own fundraising ocU¥itieS. Th ees. port appwved by the 8oard of Trusteés. MrA Kont Trustee nl& (half

HisnocYT051S UK HISnO UK srATEMvifoFTrU51EES' IIESP(X4518iun The trustees n re5P0fi51bte for PrnPaTtsy the y￿Stee$, Aeport and the Ilnandal staternefvts kn •C￿nIanCe wlth appfKable law and Unitrd ffftgdom A¢(ountiry standards {Uniied KJn8thm Genor41fy knopted A￿)untI PTrctlcol. The law applkable to thaiilies In England and Wales reouiles the trustees to prepar¢ financl81 #•tements for each financial year whith 8l¥e a tNe and lalr ￿tW OF the state of afl•lr5 of the charlty •nd of ihe lTrwmln6 rtsourtes aThd applkatlon of ￿SourCeS of the c￿rffy for th•t year. In prEP•rf￿ th•se nTr•n¢lal Sta￿Menty thetnJsTeuare rEquI￿d to: . 5elttt su5table•ctyinttry pDUr taki￿ reasonable steps lor the prevention and det•ctk>n ol fraud and other Irr*Kularilles.

HSTiocYrosis vx Hisllo UK IPIDEPENDENT EXAMINER'S REPORT ID THE TRU5TEE5 QF H15nocYT0515 UK I lE￿)rt to thè tiustees on w ex3minatlor of the Ilnanclal 5tsfrments of HIstloL￿ UK Ithe ch•iityl for th? year endtd 31 March 2025. Re5ponslbllltles and tsasls of ￿ptsrt As the tr￿tee5 of iht Ch￿lty you are rnsponjlble lor thE prnparniion of the finandal stst•m•Thts In accordance with the rèqulfyments olthe Charfties Act 2011 (the 2011 Att). I feport Sn respert of my examlnation of the chaiitV5 fnoncial ststements carrfed under sertlon 145 01 thè 2011 ACL In otrt nry exarninatltsn I hawe folloEd all ihe appliobl& ￿le£ll0n% Khen ty the Commi$5ion under sedion 14515llbl of the 2011 ACL IndepeTrdtnt 5tstrmnt Your anentttsn Is drnwn to the Fart that the ¢hartty has prnpantd flnaftd•l 5taments In accardance rfth Aco)untinK and Reportin8 by CharitFes preparing iheir actounts in gc£ordance with thi Flnanclal ftEportlry S￿ndard appl•¢able in the UK and ftepubtic Df IreSafrd IFRS 1021 In preference to the A¢rnuntlry and Ileportwbg ty Charitses: Ststtrnent of Recummended Pnctire Issued on l Apry 2005 which Is rnfvnwd kn In the •xtsnt re8ulat10ns has now been withdrnwn. l understsnd ihat th15 has been done In orOer for f￿ancial ststements lo provke a tr￿ and f•lr vlew In auofdance wlth Genernlly Accepted Accounting Prnctke effectlve for rnportinl ptrfjods b¢8lnnln8 on or after I lanuary 2015 I have omple￿￿ tny tyamlnatlon. l ￿f1fiMI that no mattws Iwe come to my 4ttenil¢n In connecllon wlth the eurnination 81¥in8 me Guse to belle4Y thai In airy materfal rtspect: accountlftB records W*PE not ktpt In ￿sp•ct ol the th•rlty as rEquir•d by se(tloll 130 01 the 2011 Pxt: or the frnanc5al statsments do pot ￿￿ord wlth those rzwrds." or the financial statEments do not cornply with the applicable requirements conornlng the form and content of accounts set ts￿t In the Charities ¢AcC(￿nts and Reportsl ReBulations 2LXJ8 other than ary requiTrmtnt th4l the accovnts 6t¥e a tnje and f•lr th whith Is not • matter fLmsld¢rnl as p•rt of • Independent eyamln4110n. I have no conterns and hawi come across no other mattefs in conne¢tion wlth itte examlnjtlon to whkh /ttentiDn shoutd be drdwn In ih15 report In order to enable a proper understandlni of financlal ststements to be Trached. Christopher McKenna ACA rcGmup 33 8ollon Boad South Hrjlbeach Spaldin8 Uncoln5hlre PE12 7LR 2317125

Himocrfosis UK Hisno ux srATEMEKf OF FIPIANaALAcnvmES IIICWDINGINCOME AMI EXPEPIDflliRE ACCOIINT roR niE VE4REP￿EO3l A14A012Q25 fvnds 2014 20 Inojme ITUM: Donations and lapclos Investmen 123.185 5.363 111.963 Totsl Income 118.548 126.827 Ra15ini funds Charitsble a¢tt¥Stteg Other exP￿d[tU i.lc 131,783 271 1281 138.011 li 133.ly ,292 Plrt •xp•ndliw• and mvmmqrt In funds 14.6061 112.4651 Aecofidll•tlon of fvn Fund balanct5 •t l April 2024 403,712 416.177 Fund b•l*ncu•t31 Math XOIS a99.106 4•3.712 The ststèrnent of fffwnclal actMtle5 Indudog all and 105ses recDonts•d In the year. Atl Incame #nd

HisnocYT051S UK Hisllo UK BAIANCE SHEÉF ASAT31 hlARC112025 Amd •sMts Tangible assets 387 R5 Cufventassets Debtor5 Cash at bank and In b4nd 14 941 405383 403.027 404.008 406.324 cr￿it0￿. amounts lallrf due wtthln one 15,2891 13.4621 398,719 402,862 Totsl ass•ts less 04rMAt Ilablllths 399.106 403.712 N•¢ •55•ts 399.106 403,712 Th• I￿15 ulth th•rlty UfftreMri¢ted fvr 399.106 403,712 399.106 403,712 v￿re approved by the trustees on .n..O.ts--.W￿< Mr A %Dnt Truse nnS5. Chalt

H15TIO UK Pa￿Es 7D TFIE FINANaAL sfATEMEP47S FOR THE YEAR EM>ED31 MAft012025 Ar£aunthypolld• The flnandil StateM￿ts h•ve been prepared In accordance wlth the dwrlty's 8vvemlni document. th• Charities Att 2011 and 'Accountiry and Ileportln8 by Charities: 51atement ol Recommended Practice applkabfe to thariues prep•rino thitr acujunts in accothnce whlk the Financial Reponlry Standard applicable In the UK a￿d Republic of Irel4nd IFf6 1021 leffeaive i January 20191". The charity Is a Publi Benefit Entliy45 dellned by FRS 102. The thartty lla% tak•n •d￿ntry of th• pro4ryslon$ IB the 50RP for tharltie$ applwni FRS IOZ Update Bulletin I not to preparn a Statwnertlol Cash Flows. The financial stst•rnents departed fTvm the Ch4rltles {Attounts and Reports) Re8ulaUons 2008 only tL¥ the exteftt to pn%ide a tn￿ and fair view. Thi5 departurn has involved loll¢yJing thE Ststement of Recommended Pnctke lor chariiles apply5nq Fli8 102 rdthttr than ihe of the Statement of Recommend￿1 PrnLllce whlth 15 referred to in the Regulations bui which has since been withdrnwn. The flnèntlal 5tatRments arE prEpared in sterlln& wldch 15 lh¢ functi?￿1 curTen¢y of the tharlty. Mtjffierary amounts in finanoal ststements aTr rourbded to tht ne•re#L Th• flnandal ststments bon P￿pa￿d unthr the hl#orfc41 ￿5t comwitlor•, tmodifi¢d to Include the revaluailon ol freehold pr¢portles and to include kn¥estment propertles ar￿ cel￿1n financlal Instruments at fair ￿lUe1. The principal accoun¢in¥ pDlides adopted are set out belw. L2 Gohw(anr•rn At the tirne of approvln8 the flnandal statements, the trustees have ? w50nable ¢Ype¢tatlon that the charlry ha5 adequate ￿OUrceS to conlSnue In operational ex15tence IDr the fU￿See•bIe fut￿￿. Thu5 lh• tIUSlees contlnue to adopt the 8olng con£ern basis 01 aCCDuntln8 in preparlni the financlal stslements. Ll ChrEtab￿ funds UnresTfEEd funos tsr ust * the dlsrtSon ￿ the trust•ts in Itrth•r•ncv of tholr chwltable Rexfitted funds are svbjert to speclfic conditlons by donots or as to how thry may be used. The puwes uses ol the ostrfaed fwxls arn s•t out In the ntstes ta the financlal stattments. Endowment funds arE 5ubiert tt> Specif￿ conditions by donots that ihe capltal must be milntsined by the 1.4 Incom Income Is fKo8Tr15ed when Ihe tharltyls legally erbtltled to it aftèr ary performance cornlltlons beeft met, theamoimts on be measured reli•bEy, and it is pmbable that IrKome will be received. Cash donatlons are wnised on receipt. Other donatlons recognised once ihe chartty ha5 bee notlfl•d of ihe donaiion. unlets perfDrniance conditions rYquivE defeTral of the amount. Income tax overable in relaiion to doBation5 FEcehed und*r Gift Ard or deEds of covenant is fe¢o8nised at the t5me gf the doftatlofi.

MLsfiocYTOSIS UK Mlsno UK PIOTES TQ ThE FINANaAL 5fAIEMW5 IcofiTINUEDI FOR THE YEARÉNDED31 MAft012025 LeBaci85 ar• r•co8n15ed on receipt or oth?rwise If ihe charity h35 been nDJfied ofan Im￿ndIn1 dlstr6butlon, the amouni Is known, and rpcelpt rs expeaed. 11 the amount 15 not known, the legacy Is trn•ted is a contingent assei. IS Expendlture All expendI￿re ¢s reCo￿lsed once there is a Iwl or coTrArnrtlve obli8at5on to that expendltufe, tt is probable settlefftent Is foqulwd and the amiwnt can bè measurEd reliabl¥. All costs •re allDc4ted to the applicable expenditure heading ihat a88re8at• Stmil•r costs to th4i ¢ats80ry, Wfvere costs ¢8nnot be directly attributed to particular headlngs tbey have been allocated on a ba515 consSstoTrt with the use of ￿50VICeS. with ren1￿1 stsfl ¢osts alkicated on the bas15 of tlme Spent, and depre£iatltyi Charg￿ allocated on the portlon of asset'.4 use. Other support ¢¥ysts ar• •llocat•d based on the sP￿4d of staff CLUts. These aro costs IncuryeLI In attractln8 ¥olunury Income. tlT• mana8ement of In¥¥trnents and those Incurred In iradinqaetl¥rtles thai r4ise funds. Charitable txpendltufe c4>mprls•s those rosrs Incurr￿ by the tharlty Fn the delhery of ￿ lctlvitres Jnd services lor its benefKEaries. tt Includes ljoth c05ts that can be alloeated directly ¢0 suth arti¥ities and th￿e Cl)Sts of an IndlTErt nalu¢e fiecessary io support them. 1.6 Tanwble IIM•d Taw'ble fLwI assets arE inttlally measured it cost and subsequ•nUy MeasU￿d at cost or r4luatlon, rtet ol deprEclatlon aftd ary impairrnent loss•s. DeP￿C[atIOn is wnlsed $0 as to wrtte off the cost ar raluatlon ol assts less thelr resldual ¥il•Je5 ovor Ihelr usefvl Ir¥es the folk>wln8 bases: OffKe equipment 33% fdu¢in8 balantè The Din or loss arfslni on th• dtsposal of an a￿t 15 dltsfftilfted as the dlfference between the SBle pmceeds and the carrying wdlve of the 355et, and is rewinised in thestatement oifinandal activitles. 1.7 Impalrnient ol IINed a55•ts At each fEPDrtlThg end date. the charity revfews the carryin8 amounts ol Its tsn8lble assets kn ￿erni7￿8 whether there is any Indi¢atlan that those a$5ets svffEfEd an Impairment lo￿ If any suth Indkation exis18 the reCoVera￿e amount ol the 3sSQt is estimated in oidw to determine the extent of the Impabrment 1055 lif any). 1.8 Cash and ush equlv•l•ftts Cash and osh e4vlYJlents in¢lude cath in hand. deposils held at oll with banks, oihei short-term Ilquld Investrnerrts with on￿n￿l rnatuffties of ihrte months of le$5, and bank o¥efflTrft5. aank <w*nlrafts •re 5bown wlthln borrowlry in Cufrent liabllttlo5. li

HisnocYr0515 UK H15llo UK FOR ThE YE4R ￿DED31 MARCH21125 Ar￿UntI￿ polkl (Coniiv4w•d) The tharity ha5 dKted to ¥ply the pro¥islons OF SertloA 11 '8a5k Finan¢i•l In5tfyments' 4nd SectlJTr 12 lthlr FIMKhl Instrnments IS$￿ ol FRS 102 to all of tts financlal instruments. Flftanflal InstNments ￿[o￿lSEd In the charftys balance sheer whn the charfty becomes party to the controttual pruvlslorts of th•1fistrument. Flnoncial assets and IlabHltles •re offseL wlth th• nrt amounts pres•nted in the firnandal Statements, wheft there is a le8ally enftjrC4ab￿ riiht to set off the wl%ed amounts and there Is an Intenkn ty settk on a net basEs or to ￿111$e theasset and settle thtt liabMislmultsneously. 8a51c financlal ss•ts, which Include Jnd cash and bank balan¢•s. •re inltlally measured at trnnsa¢tlor+ prlce includin8 trar￿alon Costs and are subsequently cardtd at amorttsed cox USinK the Ifcti¥• 5thr•Jt method unless the arorwment ￿n$t￿lUtS a fi￿n￿nI tran5a£tton, where the trnrtsxtlon k rnea5urtd at the pre5eni Alue of the futurv recelpts discountod at a mèth r4te of Ini¢rest ￿nandal assets Cla￿rIed •s rece￿ble wlthin one ￿•r not omorihed. 8aslrfvofidal&Yobllldes Bask flnanual liabllltl•s, IncSudln8 ¢redllots •nd bank loan5 are Initlally reco8ni5ed at tr4n5aclloft prk• unless the •rrdn8ement eonstltutes a finanon% tr3n50Ction, where the debt Instrument IS measured at the prESent ¥7lue of the fvtUfE p•ymentsd6swunied ot a rnark4t rdte of Intern5L Flnancial Ilabllltles dassbfied 47$ payable whhlnone yeai are not arnort&ed. Deljt Insrrnm•nts are sUb5Qqut￿1¥ ¢4rrled at amortljed ¢usL u51ng fbe effecti¥Y illterst rate mthhod. Tr•d• u•ditors are obli6•Uvns to pay for loods or se¥lces ihat been acqulred in the Qrdlnary course of operatlons from suppllern Arntsy)lts payable arE classlfied a5 cufTent Ilabllltles 11 paymeftt Is due withln one vear or le$5. If nDt. they are pwmed as non￿rrent IlablNtbE& Twade crdItO￿ •we FE(rgntsed initiaifv at trnnsartknn prke 4ftd 5ubsequen¢ty mea5wed at amortlsed cost Use￿ the effprtfve interpst mEthod. Flnancial liablllls a￿ deretO8ni5ed when the charftyes contrac￿11 obli8aiions explrE or are dlxhaiged or 17ncelle LIO EmPlo¥eeb￿¢fftS The cost of ary unused holldoy entltloment Is ￿(DInIsed In the perlod In whlch the empknyee's 5er¥kes are feceNed. Terrn•nation benefft$ recagftsed Imme(fi•tety Js an ￿pense when the tharlty 15 dem0rttt1a￿V cornTr4tkd to ten￿￿￿e the eMplo￿￿ent o14n ernplayee or to pro¥ide ternb5natkn benefft%. 12-

HisnocYr0515 UK Hwlo UK NOTES TOThE FIP4At4aALsfAYEMEl4f5 (COtinNUED) RJR THE YEAR ENDED 31 MAR012025 Ctltlul a¢w￿rtI￿ e5ttms •dh¢ments In the applkatkbn of the charfvs a The ostlrna1￿ and underfyln8 8swmptlons •¥E revlewed on an oniolry basls. ft•¥is1tyts to •rtountlnu estlm•tes are iecggnised In the pethd In whlch the stTrmate Is revtsed whae Ihe misloD aifects only that period. or in the perfod of the rEv151on and futur• perlods where lht r•¥isl(m affEcts boih curr•nt and lurure pertods Income frnm donS(ths and le••d*s 20 2024 Dffiations #nd ilfts 123,185 121.963 Donatltsns Giftaid tsx redaimed 121926 259 120,569 1.394 123,ts5 121.963 Incoffle frnm lrnAstm•srts nd5 Intefest recehAble s,a63 13

HJSTIoCYTO￿ UK Hisno UK NOYES TO THE HNANaALsfATEME1115 ICONllNUEOI FOR INE Y£4R ENDED31 AIAR012025 uTrYNtrkl￿ Uftrt#rfct•d fvr 1025 20247 Generdl fundrdlsin8and event expens I,IOD Ll81 i.ioo 1.281 Ch•rftsbl• •thhl Ch•fllatsle tswftabl• ewdlttsro &PendI￿re 1025 2024 Staff costs D•prnci¥t50ft Outreath costs Trn¥ellln8 Insurance T•l•phone Computer ewnses Pdrtllbl. P05tsRe. 5t0tl0nery￿d adverttsSn8 Ac£ountsnry. bookkee&¥Èn4 and payrall f Bank charyes Iniefe5t payable 58,986 191 8.878 4,056 1,168 lJ34 871 2,142 S8.986 419 11,937 4.289 1.170 4,077 2,218 3,103 11 4Jiiia ia8q 143 81.902 87.986 Grant tsndlnl af 4ttS¥lties Isee note 71 49*81 SO.025 131,783 138.011 14

N￿OcY[0￿s HISTIO UK NOTE5 TQ ThE HNANaAL sfAIEMENTS IcoiinNUED) SOR THE V£4RENOED31 AIARCH2025 Charftsble xpendlturn E¥pwditUfe 2025 2024 Resèarch coS 49.881 50.0 49.881 50.025 Net lunds 2025 1024 The net movement in funds15 5tsted after chargiTh8lluedldngl: DepredatiDn of owrbed tsn8ible fkyed issets L05$ on dIspo￿l of rdrylble fixed assets 191 271 419 9 Tru5th•S None DI thÈ trustees lor any porwns connected whth them) re¢•W arry reffjuMAt5on orbtr¢fits lrnm lh chafity durfn8 the year. 10 Emplry The avernge monthly number olempl¢)¥oes duriwdthoyear was. 1024 Numlb•r I￿rnb•1 Employm•rtLtsts W•8e5 and ¥l¥ies 58.986 58.986 Thefèwere nD employeg whose annua5 r•munÈrntlon was more than £60,000. 15-

HisnocYTOSIS UK Hlsno um P40TES TO ThE RNANIJALSYA7EMEP¥W5 fCONllNuEDI OR TIIE YEARE14DED31 MA&YOI2025 f¥nds 2024 20Z5 Net knsson dFsposal Df t•rylble fix•pJ 4$5ts 271 The tharfty ts &¥empt lrnm laxallon on Its acti¥ltles because all Its income Is applled for charlkble purp05eS T￿￿* illed At l Aprll 2024 DISPO￿15 5,490 35681 At 31 Marth 202$ 1.92Z D•prnd•tlgn 4nd Impalrmont At l April 2024 Depreclatlon charyed In the ye4r EllmSnated In Trspett of di5posa15 4.640 191 13.2961 At31 Ma￿h 2025 1.535 C•rrylw •mDunt At 31 Ma￿h 2025 387 At31 Marth2024 850 14 Dthors ¥lmounts fvlllncd￿e wlthln ofte y•ar: 2024 Prnpaymfftits andaccnjed irwme 981 941

Hsno ux NOTESTO THE RNAt4aAL sfATEMETh ICONnNUEDI KIR ThE VEAR ENIW) 31 MAR0120 IS Crndt0￿. aM￿¢rts1￿UTAzdUI wlthln oney•ar hw taN*ivn S[￿131 security Accruals and defErTed In¢ome 1655 2.634 iJS0 1512 5,289 3.462 IG ul net issets between funds fim At 31 Math 2D25". Tangible assets Cufferf iss•tsllll•bilrtles1 387 39B.719 399.106 UnTrth¢t•d fvnd% At 31 Ma￿h 2024: ng4ble assrf5 402,861 40J,712 17 Rdathd yrt¥ tr•ns•EUo The￿ We￿ no dlsck¥sabfe related party transactions duiing the yeaT12024. nor)el. 17

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