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2025-12-31-accounts

JNETICS

(A Company Limited by Guarantee)

DIRECTORS’ REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2025

JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2025

Legal and Administrative details
Directors’ Report
Independent auditor’s report
Statement of Financial Activities
Balance Sheet
Statement of Cash flows
Notes to the Financial Statements		 Page

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4-8
9-11
12
13
14
15-22

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JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2025

Directors & Trustees: A L Angel
A M Leon
L Blitz
Dr M Ziff
E May
Dr J Harris
A H Freinkel (appointed 24 March 2025)
J M Krell (appointed 24 March 2025)
Registered Office: 505 Centennial Park, Centennial Avenue,
Elstree WD6 3FG
Independent auditor: Goldwins Limited, Chartered Accountants
75 Maygrove Road,
West Hampstead, London, NW6 2EG
Bankers: Barclays Bank UK Plc
1 Churchill Place
London E14 5HP
Charity registration number: 1134935
Company registration number: 07087270

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JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2025

TRUSTEES / DIRECTORS’ REPORT

Principal Activities and Charitable Objectives

The charity is established for the following purposes:

In establishing the activities of the charity, the directors have given due consideration to the Charity Commission's guidance regarding the provision of public benefit. They consider that the activities described in this report have delivered significant public benefit. Through education, screening and awareness programmes, Jnetics has enabled individuals and families to make informed reproductive and healthcare decisions, supported earlier identification of hereditary cancer risk, and contributed to reducing the burden of serious inherited conditions within the community.

Achievements and Performance

2025 was a landmark year for Jnetics. The charity delivered record levels of recessive genetic screening, played a leading role in the highly successful NHS Jewish BRCA Testing Programme, expanded its educational and outreach activities, strengthened its scientific and medical governance, and continued to broaden and diversify its fundraising base. Through these activities, Jnetics further advanced its mission of reducing the impact of Jewish genetic disorders and hereditary cancer within the community through education, screening and support.

The NHS Jewish BRCA Testing Programme, which following a pilot period was officially launched in January 2024, closed to new applicants on 31 October 2025. The programme, delivered in partnership with Chai Cancer Care, was far more successful than expected with over 44,000 individuals registering for screening before 31 October 2025. Around 74% of applicants returned their testing kits and over 680 BRCA carriers were identified and are now able to access enhanced surveillance, preventative interventions and specialist support, significantly reducing their future cancer risk.

The programme's success led to a significant milestone when, in light of the programme’s success, the NHS determined that BRCA testing for individuals of Jewish ancestry should be integrated into routine NHS practice from 2027. The NHS Jewish BRCA Testing Programme is expected also to serve as a blueprint for similar initiatives in other communities.

As a result of the programme Jnetics has increased its focus on hereditary cancers and reinforced its position as a primary source of information, education and screening for the Jewish community in relation to dominant genetic conditions.

During 2025, all three of our recessive genetic screening programmes experienced substantial growth. Across all three recessive screening programmes, Jnetics screened 1,591 individuals during 2025, the highest annual total in the charity's history.

The Jnetics Clinic saw significant year-on-year growth, screening 549 individuals compared with 239 in 2024. This includes 142 former students and friends of King Solomon High School in Essex at a mass screening event attended by over 400 people inspired by the former student parents of a child with Tay Sachs.

4

JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2025

Our Campus Screening Programme continued its upward trend, with 361 students screened in 2025, compared with 344 the previous year despite the increasing numbers of Jewish students screened in schools.

The Schools Programme also saw exceptional growth, screening 681 Year 12 students, up from 493 in 2024. In addition to maintaining our presence in all eight mainstream Jewish secondary schools, we expanded further into non-Jewish schools with significant Jewish student populations, broadening our reach and impact.

The virtual format of both the Clinic and Campus Screening Programmes enables us to reach more individuals across a wider geographic area, improving convenience while reducing both costs and time commitments. The Schools Programme remains fully in person, allowing us to maintain the educational element that is integral to its success and supports one of Jnetics' key long-term objectives: increasing awareness and understanding of recessive genetic conditions among young people

On the fundraising front, the Directors recognise the challenges associated with delivering a major fundraising initiative, such as a matched funding campaign or gala dinner, every year. Given the size of the organisation and the demands placed upon the community, especially in light of current events in the Middle East and growing antisemitism in the UK, the charity has adopted a two-year fundraising and budgeting strategy. Consequently, no major fundraising campaign was undertaken during 2025. Instead, efforts focused on strengthening existing events, developing new initiatives and diversifying income streams.

Following the successful matched funding campaign held in November 2024, the first quarter of 2025 was relatively quiet. However, the expansion of the fundraising team, including the appointment of a dedicated Events Officer, enabled further growth of the Young Professionals Committee and the introduction of several new initiatives aimed at engaging new and younger supporters in particular. This included a number of new challenge events, broadening the charity's appeal and participation opportunities.

A particular highlight of the first half of 2025 was the second Jnetics Ladies' Night. Attended by more than 200 women, the event generated significantly increased income and has now become a highly anticipated and established fixture in the fundraising calendar.

Other key achievements during 2025 included:

5

JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2025

Post Balance Sheet Developments

Plans for Future Periods

During the second half of 2026, alongside a continuing focus on recessive screening, we will be working closely with NHS England to ensure the successful integration of BRCA screening for the Jewish community into routine NHS practice. A seamless transition to this new delivery model, underpinned by strong and ongoing community engagement, will be vital to maintaining public confidence and continuity of care.

In the final quarter of 2026, and in line with our two-year fundraising cycle, we plan to launch a matched funding campaign to secure funding for the coming 2 years.

The second half of 2026 will also see the continuation of existing awareness activities alongside the launch of new initiatives. These efforts will support the further expansion of our donor database and help attract new supporters to the charity.

Additional events within our well-established Scientific Lecture Series will continue to address growing interest in genetics and hereditary health. The series has played an important role in strengthening Jnetics' reputation as a credible and respected voice within the medical and scientific communities.

Continued engagement with, and support from, the community remains central to our success. Encouragingly, we are seeing increasing awareness of Jewish Genetic Disorders (JGDs) and a growing understanding of the vital role that Jnetics plays in prevention, education, and community health.

We plan to expand our challenge events portfolio by introducing new fundraising opportunities during 2026, including participation in half-marathons; 12 places secured have already been filled. In addition, the annual Jnetics Golf Day, scheduled for July 2026, has again reached full capacity.

In line with growing demand across our programmes, we anticipate investing in the continued growth of the Jnetics team. Expanding our capacity will enable us to deliver our core objectives more effectively and maximise our impact.

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JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2025

In memoriam

In this Report it is important to mention the passing of two individuals who contributed so much to Jnetics.

Peter Jacobs z”l was founding Chairman of Jnetics from 2010 to 2016. Peter played a pivotal role in establishing Jnetics and shaping it into the remarkable charity it is today. His vision, dedication, and leadership have left a lasting legacy.

Professor Patricia Jacobs z”l was a scientist of rare distinction, a person of exceptional generosity and one of the great pioneers of modern human genetics. Her influence helped ensure that the Jnetics is rooted in the best science, guided by ethical thought, and motivated by compassion.

Financial review

Principal sources of funding

The charity receives most of its funding from donations and was able to claim gift aid where applicable.

Results for the year

The financial statements for the year are set out in pages 12 to 21. The Statement of Financial Activities on page 12 reflects a deficit of £6,744 (2024 - surplus of £398,720) for the year ending 2025.

Reserves

The Directors review the reserves policy annually. The policy is to maintain free reserves equivalent to approximately six months' operating expenditure. At 31 December 2025 unrestricted reserves stood at £779,537, which the Directors consider appropriate in light of the charity's activities, future commitments and the planned use of reserves to support growth in screening and educational activity during 2026, a year in which no major fundraising campaign is scheduled.

The charity's total reserves at 31 December 2025 amounted to £854,165 (2024 - £860,909).

Structure, governance and management

The Board met 4 times during the year and received regular reports from management on operational, financial and strategic performance.

Status of Charity and Governing Document

Jnetics ("the charity") is a company limited by guarantee (No.07087270) and a recognised English charity (No. 1134935), governed by its Memorandum and Articles of Association. The charity was incorporated as Jewish Genetic Disorders UK on 25 November 2009 and changed its name to Jnetics on 2 July 2015.

Appointment of Directors

New Directors are nominated for appointment and appointed by the existing Directors until Jnetics next Annual General Meeting. If confirmed, they serve until the Annual General Meeting at least three years after appointment and, subject to reappointment.

Prior to their appointment, new Directors would be familiar with the charity's values, its aims and objectives and its day-to-day operations.

As part of their induction programme, new Directors are required to understand their statutory Responsibilities.

7

JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2025

Statement on Risk

The Directors assess the major risks to which the charity is exposed on an ongoing basis and are establishing procedures to mitigate those that are identified as a result of these reviews.

Office Bearers

The Directors who served during the year and to the date of this report were as follows:

A L Angel A M Leon L Blitz Dr M Ziff E May Dr J Harris A H Freinkel (appointed 24 March 2025) J M Krell (appointed 24 March 2025)

Trustees / Directors’ responsibilities

Company Law which is also applicable to charitable companies in England and Wales requires the Directors, who are also Trustees of the company, to prepare financial statements for each financial year which give a true and fair view of the state of affairs of the company and of the results of the company for that year.

In preparing those financial statements, the directors/Trustees are required to:

The Directors/Trustees are responsible for keeping proper accounting records which disclose with reasonable accuracy at any time the financial position of the company and to enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

Small company exemptions

The above report has been prepared in accordance with the special provisions of Part 15 of the Companies Act 2006 relating to small companies.

This report was approved by the Board of Trustees / Directors on 28 July 2026 and signed on its behalf by:

A L Angel Director and Chair

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Independent Auditor’s Report To the members of Jnetics

Opinion

We have audited the financial statements of Jnetics for the year ended 31 December 2025 which comprise the Statement of Financial Activities, the Balance Sheet, statement of cash flows and the related notes. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including Financial Reporting Standard 102: The Financial Reporting Standard applicable in the UK and Republic of Ireland (United Kingdom Generally Accepted Accounting Practice).

Opinion on financial statements

In our opinion the financial statements:

Basis for opinion

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the Auditorʼs responsibilities for the audit of the financial statements section of our report. We are independent of the Charity in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the FRCʼs Ethical Standard and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Conclusions relating to going concern

In auditing the financial statements, we have concluded that the trustees’ use of the going concern basis of accounting in the preparation of the financial statements is appropriate.

Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the charity’s ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.

Our responsibilities and the responsibilities of the directors with respect to going concern are described in the relevant sections of this report.

Other information

The trustees are responsible for the other information. The other information comprises the information included in the annual report other than the financial statements and our auditorʼs report thereon. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon. In connection with our audit of the financial statements, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether there is a material misstatement in the financial statements or a material misstatement of the other information. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We have nothing to report in this regard.

9

Independent Auditor’s Report To the members of Jnetics

Opinion on other matter prescribed by the Companies Act 2006

In our opinion, based on the work undertaken in the course of the audit:

Matters on which we are required to report by exception

In the light of the knowledge and understanding of the Charity and its environment obtained in the course of the audit, we have not identified material misstatements in the Trustees’ Annual Report.

We have nothing to report in respect of the following matters where the Companies Act 2006 requires us to report to you if, in our opinion:

Responsibilities of the trustees

As explained more fully in the Trustees’ Responsibilities Statement, the trustees (who are also the directors of the charitable company for the purposes of company law) are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view and for such internal control as they determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, the trustees are responsible for assessing the Charity’s ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the trustees either intend to liquidate the Charity or to cease operations, or have no realistic alternative but to do so.

Our responsibilities for the audit of the financial statements

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditorʼs report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.

Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, including fraud are set out below.

In identifying and assessing risks of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, our procedures included the following:

10

Independent Auditor’s Report To the members of Jnetics

A further description of our responsibilities for the audit of the financial statements is located on the Financial Reporting Councils website at: [www.frc.org.uk/auditorsresponsibilities]. This description forms part of our auditor’s report.

Use of our report

This report is made solely to the charitable company’s members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the charity’s members those matters we are required to state to them in an auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the charity and the charity’s members as a body, for our audit work, for this report, or for the opinions we have formed.

……………………………….

Anthony Epton (Senior Statutory Auditor) for and on behalf of Goldwins Limited Statutory Auditor Chartered Accountants 75 Maygrove Road West Hampstead London NW6 2EG

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