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2022-12-31-accounts

JNETICS (A Company Llmlted by Guarantse) DIRECTORS, REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2022

JNETICS (A Company Limited by Guardnteel FOR THE YEAR ENDED 31 DECEMBER 2022 Pa Legal and Administratwe detaifs Directors, Report Independent examinerfs report Statement of Finanaal Ath"vitEs BalarKe Sheet 10 Statement of Cash ftows 11 Notes lo th& Financial Statements 12-17

JNETICS (A Company Llmited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2022 Directors & Tn￿te￿. ALAngd AmL￿n L Blrtz Drmziff Emay L Bimbaum Dr J Harris N GddschneKler lapFointed 1 September 20221 (appointed 1 September 20221 {appoint&l 18 May 20221 Regt8tered Office: 505 Centennial Park, Centenn431 Avenue, Elstreo. WE￿ 3FG Independent Examiner. Gothvins Limrted. Chartered A¢zDuntants 75 Maygrove Road. Wesl Hampstead, LotKlon. ￿ 2EG Bankers: BarcLgys Bank UK PIC I Churchill Place London E14 5HP Charity rogistratlon number. 1134935 Company registration number. 07087270

JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2022 TRUSTEE I DIRECTOR ' REPORT Principal Activities and Chaiitable Objectives The charity was established for the foll(Iwing purposes.. To increase awareness and understanding of Jewish genetic disorders IJGDs} among affeGted families. patient groLtps. healthcare profassionals. and the Jewish and wder community. To improve ac(tss io the best available infotmabon. se￿1￿$. and support rebling to Jewish geneknc disorders. To facilitate access to respK)nsible and profess￿nal testing serV￿Sfor people at risk of passing on, and those affected by, Jewish genetic disorders. In estrdblishing the actNities of the charity. the direclors have gwen due consideration trj the Char￿1 Commission's guidano regar(ling the proviS￿n of public t*nefrt. A¢hlevements and P•rforrnanco The first ha￿ of 2022 saw the launch of the chafity's first matched funding campaign, which rais6d £464,024.03 and successfvlty intrOdU￿d 2,500 new donors lo Jnetics, helping us to delNer on our tsvin obj8Ctives- to ansure no furtherchild￿￿ are bom into our community with any of the devastating genetic conditions that Jneli¢s tests for and to improve the preventKJn and management of Jewish Genetic Disorders. The second half of 2022 saw the introduction of a number of new awareness buikling and fundrai&ng avenues, including Jnetics, fir51 Young Piotsssionals, event, a supper quiz attended by 200 young adults and the laurs¢h of a series of sC￿nI[fir lectures enabling us to build on the expande(S reach and rnomenturrt from the matched ftjnding camp8wJrT. The ftJndr8ising suc￿SseS enjoyed in 2022. achieved financial stabilty for th& organisation, enabliny development of the resour￿$ required by Jneb"cs to Support the needs of the com¥nunity. Further highlights of 2022 induded.. our Gala Dinner rn Central London attended by 200 of the charity's key donorslstakeholders. The dinner prowded the opportunity to share with them and the Wkder community information on the three-year NHS England BRCA screening programme for anybody with one J￿1$h grandparent. The soft launch commenced on 30th January 2023. In October 2022. Jnetics. wort(ing in partnershipwrth Chai Can￿r Care, was appointed by NHS England to deliver the engagement campai9n to the community in support of the new BRCA screening programme. We developed Jnelics, branding lo improve its impact, reflect the devekjpmentof our screening programmes and tie into the range of media we now use to communicate with the communty. A new Jnetics website was launched Octcbw 2022, wh￿h has a pc6itwe impact on the work that we do. 2022 saw growlh acrtr6s all 3 recessÉve scre8ning programmes. The Jneb"cs Clin￿ conb'nue5 to function al near capacity each mnth. despite the rntroduction of an extra clini¢ (318 participants in 2022 vs 218 in 20211. The schools programme has now recovered to pre£0￿d levels. During the 202212023 ac8demic year, together wtth educats.ng and SCTeening in all 8 rnainstrearn Jewish secondary schools, we have begun the prctess of screening and educating in non-Jewish schools with a large number of Jgwish sludenls1328 fomi students in 2022 vs 217 in 20211. The Jnetscs on Campus universities programme continves lo dernonstrate year on year growth with 244 students screened during this academic yèar (209 in 2021}

JNETICS (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2022 The success and growth acu)ss all 3 ofour screening prOgr￿me9 can in part be attr4buted to the new expanded panel (launched Sept 2(r211 which has increas&Y our relevance wthin all sectors of the community.. in the ￿se of the dinic the introducbon of "couples screening" appeals to screening part¢ipants thinking of h8ving a child. The rrTrove lo a viriual screenirig process for the clinic and the universicies programme has also enabled us to screen greater numbers across a wider geographic reach al greater convenience to parkn.￿pants and reduced time and cost. The schools, pro9rammes remain in person. Plans for Future P•riods The first haff of 2023 has again got off to an en(Duraging stsrL The ne4V NHS BRCA screening programme soft launch on 30th January exceeded all expectations. with over 2,100 people signing up to be screened. Aclwity has focuséd on engaging comrnunfy stakeholders to ensure the community are tth aware and property supported as we gear up for the hard launch, n¢)w scheduled for late Autumn after some delay caused by inadequate screening capa(yty in NHS England- an issue n(Iw addressed. The pilot scheme ha5 led to an increased fctus for Jnetu in heredrtary cancers. Jn8ti¢S CL)ntinues to aim to be communty's primary initial ￿sOUrc& for both r￿S$￿e and dominant disorders. In January. the charity held its fiF5t ladies luneh event Thrs was a great success and intrOdU￿d a number of new faces to the liFe5aving work that we do at Jnetics. This will now be a pemianent fixtu in the fundrai&ng ￿lendar. In hAarch. IhÉ ¢harity hekl its second matched funding rampaign. wh￿h proved even more suceEssful than the first The succgss ofthis campaign has ensLEred that forthe durakn.on of 2023 Jneti(s can delNer its screening programmes and continue to educate the communty about JGDS. The second haff of 2023 will see the introduction of new varene5s building and ftJndraisin9 avanues, as well as the development of e￿Sts"n9 channels a golf day. Jnetics, second Young Professionals, even( and further events in a series of scienttfic Wures which will enable us lo further expand the Charity's role in educating the communty on preventi)n and better management of JGDS A great deal of focus wll be pla¢d on ¢JevekJpJng the engagernent campajgn in support of the new BRCA screening progTa¥nme. Ensuring the communty i8 well informed, educaled and supported Ihfough every step of their BRCAjourrw is at the core of our wor Looking ahead, we see the opportunity to build solKI foundations for our fvture actrvthes, to improve our delivery. effici8ncy and effectiveness, together with great potential from our ewanded panel and the opportunity lo move fornyard our work in refation to heredttary cancers. Engagement with and 5UPPOrt the community rem8in critul and continues to improve. We have seen a signfficanl increase in awareness of the communty in reLqlion to JGDS and the important role of our work. enabling us lo achieve our objectives more easily. Financial revlgw Principal sources of funding The chanty receives most of its fvnding from donats.ons and was ab￿ to claim grfl aid where applicable. Re3ults forthe year The financkryl Statements for the year are set out in pages 9 to 17. The Ststement of Financi31 Activit￿$ on page 11 r91￿ 8 surplus of £154,60812021_ deficit of £177.023} in the year Reserves The charity aims to maintain free reserves suffiaent to finance its operating c05ts for ar￿nd 6 months. ReseNes in ex￿$ of this amounl a￿ applied lo further the chartly's objectives. The tharity'g reserves on 31 D￿mber 2022 amounted lo £221,33512021 - £66.7271. of which £203,335 {2021 _ £12,343) reL2ted to unrestricted futKls ana £16,OC()12021 - £57.2091 to reSt￿ted fvnds.

JNErics (A Company Limited by Guardntee) FOR THE YEAR ENDED 31 DECEMBER 2022 Structure. Govemance and Alanagemont Jnetics {'Ihe charity") is a company limrted by guaranlee INo.07087270) and a recogntsed English charity {No. 11349351, govemed by its Memorandum and Articles of Association. The charity was incorporalgd as Jewish Genebc Disorders UK on 25 November 2009 and changed rts nome to Jnetics on2 July2015. Appointment of Dirgctor8 New DirectOTS 8re nominated for appointrnent by th8 existing Directors. There is a three-year term for Dir6etorship subjèct to reappK)intment. Prb?r to their appoinlmenL new Directors would be familiar with the charity's values, tis aims and oty"ectNes as well as rts daY-t￿daY operations. As part of their induction programme, new Directors are required lo understand their statutory responsibilrties. In the course of its efforts to improve rts g)¥em8nce Struc￿￿. three nthv trustees were appointed in 2021. St*ement on Risk The Directors are assessing the major risks to which the charrty is exposed on an ongoing basis and are establi8hing prO￿d￿reS to mitrgate those that are identFfied as a result of these rewews. Office Bearers The Directors who served during Ihe year and to kne date of thi8 report weEe as follows." A L Angel AMLeon L Blttz Drmziff Emay L Bimbaum Dr J Harris N Goldschneid8r (appointed 1 Septem￿r 20221 {app04nted 1 SepterRber 20221 (appointed 18 May 20221 Trustees l Directors, responsibilities Company Law which is also applicabla to charitable companw in England and Wales requires the directors. who are aL%o Trustees of the company, to prepare financial statements for each finanaal year which g￿ve a true and fair vrew of the state of affairs of the company arKI of the results of the company for that year. In preparing those financial statemenls. the directo￿￿￿$tees are required to.. select suitsble accounb.ng poliaes and then apply them consistently.. make judgements and estimates that are reasonable and prudent." and prepare the financial statements on the going concern basis unless it is inappropriate to p￿SuM￿ that th• company will ￿n1FTrue in buBines¥. The directOts￿ruslees are respon￿ble for keeping proper accounth.ng records which disclose wrth reasonable ac(aJracy at any tirne the financi￿ pc6ition of the company and to enable them to ensure that the financ>al statements compty writi the CompanEs Act 2006. They are also responsible for safeguarding the assets of the company and hen￿ for tsking reasonable steps for the provention and detection of fraud and other irregularities.

JNErics (A Company Limited by Guardnteel FOR THE YEAR ENDED 31 DECEMBER 2022 Small company exemptK)ns The above report has prepared in accordanc* with the provisKin5 of Part 15 of the Companies Act 2006 relating to srnall companies. This rewrt w?S approved by the Board ofTwstees I tArectr)rs o by.. nd signed on its behalf ngel rector and Chal

JNErics (A Company Limited by Guarantee) FOR THE YEAR ENDED 31 DECEMBER 2022 INDEPENDENT EXAMINERS. REPORT I report to th8 charity Trustees on my examination ofthe ac￿￿nts of the Company for the year ended 31 December 2022. Re8ponslbilities and basis of rpport As the charity's Twstees of the Company (and 8130 rts drreclors for the purposes of o)mpany law} you are responsible for the preparation of the acLx)unts in accordance wth the requirement5 of the Companies Act 2006 {Ihe ACY). Having satisfied myself that the accounts of the Company are not requir&l to be audited under Part 16 of the 20Q6 Act and are eligible for independent examination. I report in resp&t of my examination of your charity's accounts as camed out under seGbon 145 of the Charities Act 2011 I'the 2011 Acl'l. In carrying out my examination I have follrywed the Directions given by the Chanty Commission uniaer section 145{5) Ibl of the 2011 Act. Indepgndont ￿&Mina￿S statement I have completed my exarninat￿n. I confirm that no matters have come lo my attention in connection with the examination gNing me cause lo believe: 8¢counting records were not kept in resK*Ct of the Company as required by section 386 of the 20C6 Act.. or 2. the aecounls do not a¢¢ord wrth those records." or 3. the accounts do not compty the a¢xounting requirements of section 396 of the 2006 Act other than any requirement that the accounts give a 'lrue and fair view wh￿h is not a matter consKlered as part of an independent examination,. or 4. the accourrts have not been pr&paretl in accordan￿ wrth the methods and principl&s of the Statement of Recommended practi￿ for accounting and rEPOrting by charit£es applicable to charrttes preparing their acc£Junts in accordan￿ with the Financial Rep)rbng Standard appl￿ble in the UK and Republ￿ of Ireland (FRS 102). I have no concems and have come across rto other matters in connection wrth the examination to which attention should be dmin in this report in order to enable a proper understanding of the accounts to be ￿aChed. Anthony Epton BA FCA CTA FCIE Goklwins Chartered accountsnts 75 Maygrove Road West Hampstead LorKlon 2EG 7 August 2023

Jnetlcs Statement of financial activlties (incorporating an income and expenditure account) For the year ended 31 Decembor2022 2022 Totsl n(Is 2021 Total funds Unrestrictcd Oesignated Restrictgd fund5 funds Income from: Donations 50.495 50A95 50,222 Charitable actimties.. Grants ChallèngeEv8nt8 5ncome Appeal Income Patronage TrtJsVScreening income Govemment Grant Tnbutes and celebrab.ons Gala Dinner 8RCA Investment income Total income 100,000 13,880 100.IJOO 13,880 506.264 108.000 55,183 146,448 37.513 50.670 5.025 9,093 70,400 70.400 79.889 79,889 18,000 18.000 821972 18,000 840.972 462,160 ExpeTtdI￿r9 on". Raising fltnds Ch8rit8ble ￿NItreS 241975 386.180 241975 443,389 180.159 459.024 57.209 Totsl expendÈbJre 629.155 639,183 Net Income I (expendi￿re) ttfore net gains 1 Ilossesl on investments Net gains I (losses) on investments 193.817 {39.209) 154,608 1177.0231 Net income I l•xpenditurg1 for tho y 193.817 {39.2091 154608 1177,0231 T￿nsfer5 btheen lunds Nat mov8ment in fund¥ (2.825 190.992 2.825 2,825 139.209) 154.608 1177.0231 Reconciliatlon ol funds: Tot&1 tjnds br￿ght forvrard 12.343 2,8251 57.209 66.727 243.750 Total fund¥ carried forward 203 335 18.000 221.335 88.727 AJI of the at¥)ve results are derived frcmn cy)ntinuing adivrti8S. There were no other wnised gains or ￿herthan those S￿ed ato¥e. The attached rKJtes form part of these financial siaten*nts.

Jnetics Balance sheet As at 31 December 2022 2022 2022 2021 2(Y21 Nots Flxed assgts: Tangible assets 10 488 Current assèts: Dabtots Cash at bank and in haThJ 11.701 438.789 450.490 29.747 217.215 246,962 Liabilities.. Creditors." amoLtnts falliffj due ￿￿1n one year 12 180.723 Net currant assgts 217,036 66,239 Total ngt ass•ts 221.336 66,727 Funds Restricte¢J funds unrestn.ded fvnds". Designated funds General funds Total unrestricted fvnds 14 18,000 57.209 12,8251 12,343 203.335 9.518 Total funds 221.335 66,727 The Ch2Ws finarrial statemènts have been prepwed in aC￿rdan￿ h￿th the promsions appli(sble lo companies subject to the small companies regime. Trustee5 consider that the Chanty is eth.tled to exemption from the requirement to an aL¥Jft under the prOVi￿On of section 477 of the Companies Act 2006{Wie Ad'l and memters have not required the Charttry to obtain an audit for the year in question in a¢rnrd3r￿ wth section 476 of the act. The Trustee acknovAedge th￿r reSp￿S￿b11the5 for Y￿ttl the requirement of the Cotnpanies Act 2006 with respect to acc(xJ lec￿15 and the prewat¥)n offinanrial statements. Approvej bythetrustee5 0 ......... . arKI signed on their beha Company regis 07087270 The attathed notes form part ofthe financial statements. 10

Jnetics Statement of cash flows For the year ended 31 December 2022 2022 2021 Net cash provlded by I (used in) oporatlno actlvltk8 228.022 127,2491 Cash ffows from investjng a¢￿vI￿e9. Salel Ipurcha5el of fixed assets {6A481 Cash provklod lry I{uS￿ in) Investing activrt Chang8 tn cash aTrJ ca¥h eqw¥alents in the year 16,448 221,574 127,2491 Cash and c2sh equNaWs at the innirrfJ of the year 217,216 244.464 Cash arKI cash equlvaknts attha èrni of the year 438.789 217,215 al Recon¢lliaUon of net income I {expenditurè} to net cash Ilow from 2022 2021 Net Income I {eX￿n￿lture1 for Ihe reporting perlod las per the ststement ol finanual acb'vitiesl 14808 1177,0231 Depreryats'on (In￿8$eV decxease OebtOFS Increasel IdeL¥easel ill ￿￿tt0[S Not cash provided by i (used inl 2,857 27,206 119.711 18.046 52.731 27.249 bl Analysis of cash artd cash 8quivalents At January Other 31 December 2022 CAsh flo￿ changes 2022 Cash al bank and in hand 217.215 221,574 438,789 Total cash and eagh equivalEnts 217,215 221.574

Jttics Notes to the financial statements For the year ended 31 December 2022 1 A¢¢ountlng po16cb88 al Bas￿ ot PTeparatioTr finanual staten￿$ h￿e teen in 8c4x¥)Ia￿2 ChatiO". StateTrEnt of RecommeThleo Practts app￿￿￿¢ lo LtsrFbes KxEparir¥J tsr accLWrts In accordan￿ vath the FinanL¥81 ReKx)rbry Stsndard dpk1Kab￿ In the UK and ￿e￿IC of Irr>J (FRS 1W2 - effetbve 1 January 2015) - Ichatilies SCIRP FRS f0218nd the c￿panS A(12(￿. The tharitsble ￿anY mtS deffin￿n ol a Le￿fft ￿trIY FRS 1Qk2. A#Èts arkl na￿lItieS are In￿81 recognised ai hkStori￿ ¢ost or trartsaiti￿ ws5 01ha￿lSE5trted In rv8nta• tyAiGy or note. bl Golng cort¢em The tsust8ts ￿n54)er that tyEre ap rK) rnrral wKrtainbes atM)ut Ihe thartPdlAe cy)mparr¢5 a￿litY lo conbnue as a goirKJ 1x)n￿rn. trustee5 c(rrider Ihai ￿re are any sowc8s of e5hrnab"M urKXtainty al IhE repDrtifg datè that have signrfK&nk n5k of CQLL%in9 a material adjustrrwl lo ts (xt¥y4vJ amrxJrt5 of 8ssets and liablrtEs the rÈxt reporbng reriod. cl Inco lTrc(xne is rec(xJrti8ed Ihe charity has entidettrrt lo films. arry wfomnce c￿drt￿nS attached ID thp ir￿7￿￿ have been rneL ti 15 kYobatAe Ih3tlhe DK4JmeMiH ￿ retJ arKI that aTwJrt can Treasut&l rdiab Ir￿oMe from gwrw ￿ otrw gTrnts. 'c4p18f gr3nts or 9ranrs. the charity has enfjJenknt to the fuEVJs. any cotKldions attacFEd to its gtanrs havg ten tneL rt i3 prOb8b￿ ttlgt irwme Mll be reraved aryj the arbTh)utrt 13n te measured relthty arml i5 ncldefe[￿l. te(¥ved in advan￿ fty tIE proviskM ofsp8rxfied d> lrterp5t ra¢el¥ab IntÈfest on fvrKJS The￿j rm t[￿'t i8 v#En re(i¥th aThl the arwrt (xn t ftwsU￿y rdh1bty by tr (tharity.. tlis is normaKy upon nCtrf￿at￿ olltrE ￿rte[ESt paid (K pay by ts ban e} Fund accountrng GerEral funds are untestrKtsY %itic ate avL x w at I￿s￿e1th of ttE T￿￿tee5 in the ftJrtrwanc8 of the genetal objecbves of thanty f¢ve not de5vJnated for trttrEr rAJfposÈg Restrirled fums are (S(x)atsons and grants solety uwj for part¥Wkr8reas ofthe th8rly'5 DEkcrfor¥kyikprcts ￿r￿j uThrtAken byth& chanty. fj Expertdiiurp Expen¢tur8 * re￿r￿¥&j ltrwe i8 a W or conslft￿ O￿VJaIlOn to m8 a pafftnt to a thJd patty. It is protsab￿ Ihal settra￿t￿￿11 be rnq1l￿d and the arTr)Lml obl￿aLlOn f2n be rr￿a$￿￿ rdbly. ExpetKSiture rx) funds camwse the 91 AUo¢auon ofsupport c¢)sts Suppon ￿sts ore those fU[KJKX￿ Ihal asst ofthe not dreialy L￿d￿tske tharitsNe ar¥ibes. Suppott ¢osts indude back Offi￿ costs. finan￿, p8rsow. pa￿1 ar￿ governan￿ sUPPOrt the thariws gdDithe5. T1488e h) TJJn9iblo I1x￿ ¥s69ts TangIb￿ fixed assets are staled at a>St or valuation less dewe(aation. DeprefaatK>n LS prov￿ at rnt¢s GabJlated lo vKite the c05t of e8th as￿1 to its e5tirnated feswsuai value o¥er lrfe TrE depwation rates as fol￿.. co￿￿U￿r eqLRWn￿rt Fumitute Frtbngs 3 y¥sstsavJht I D•btors Trade and olkEr debtotE are reco9fm￿ at ￿ setsYErrt an]ount ¢Jue after atryts dis(xxrt 0fter￿. PrepawTrnts aFe vakJpAJ at the arnount prep3J net Ofarry trJe d￿)￿ts I Cash ¥t bank and hand Cash al bank atQ cash in haNJ NKhles cash term Ii4LNd IrThe5&7￿ YAith a 5b)rt matwty of mg tr¥)ntt or Irom the dÈ Ofa￿￿%)n dtsWcrsiir a¢￿ kl C[￿llor88￿d Prov￿10￿$ Credrtors and prO￿s1(￿S a￿ rpcogrds•J cfty h85 a fr(￿ a Past e4eni mai ill kyoba￿y sull In the transfer of hjrkts to a ttxrd party anKKrf dtse tr) sth trE oNpJation ran be mea8ur&J or e5b"m8te(I reli3biy. Cre(lttors th prowsMs are n(*rnalty re￿9[￿1 atlhelr sellieffwrt rnntarter all¢M4ffj foranytr•JE d￿CoUnts d￿. 12

Jngtics Notss to the financkgl siatpments Forthe year ended 31 Dec8rnber 2022 2021 fu￿9 D￿atrOn$ 28.291 23931 28.291 23,931 Chantabl• G￿nts CbaletEvents Ints Ap9eai Income Patsonage 1D3.D 1D8.000 $5,1B3 146 440 37513 50.670 5.025 9.093 55.183 146.448 37 513 5D.670 Govemrn•ttGrdrrt Intorést T4Jl•l irKorne 3591 103.OiXI 482 160 c1￿1¢ab￿ A(b7bqs Ra￿An￿ 314.73fj 124. T41,412 55,349 456.168 180.759 2.857 629,18 TOtsieW￿NWe 197.261 (94.251) {17T.OZJI 151.T39 tZ31 1M) P4et incomeff{*wfKUtyreTr 12. 56,978 11TT.0￿) Tolalfunds L¥Whtftwtd 243,487 3Z 2.825 231 243.750 86.727 57.209 2D21 Toiai funtrs fvnd5 ndÈ ¢&fthJd 9￿53 291 23 931 2021 Total Trtal Grarts ChallÉwwEverts IrKc Appeal InL￿o P3tronèJè Tru$115cwirvJ Qovemment tsr4nt TnbuiE5 and Ga￿ Thnnèr BRC4 108,0 .183 146.448 37.St3 SO.670 5.025 9.093 13.800 264 1043 18.000 1￿2 2022 2￿1 Tokl 13

Jnetics Notes to the financial statements For the year ended 31 December 2022 Anatysis of expgndltyro raisi Stsff ￿sts S(Jeening Database Insuran offi￿ costs Telephone Post Sundry Ac￿untan￿ Con5ulancy B8nk and Online Fees Legal 8nd Professional Subscriptions Depreaation Websitè Awareness Meelingttravel Fundiaising Pan61 Expan￿0￿ Costs Geneb'c CoLtn5dling Costs G818 Dinner Expenses Independent examination I￿$ Losses on (￿rrercY exthange 220.519 156,924 3A57 1348 19.935 220,519 156,924 3A57 1.248 19.935 1.363 2,178 4,659 14,088 9.605 2.705 361 350 2.637 21,036 39.757 1.739 29.819 203,149 187.135 3,253 1,277 16.636 1.347 2,357 2,121 21,605 13.583 2.674 2.178 4.6S9 14.088 9.605 2,705 361 350 2.637 126 2.857 4,087 32,853 372 48.Q35 4.200 90.612 21,038 39,7S7 1,739 29,819 89235 47.846 89,235 47.846 3,380 13,543 39.943 686,364 3,360 13.543 242.975 403N46 639,183 Support costs 39843 139.9431 Total exp8nditur• 2022 242.97S 443,389 686.364 Totsl expandiknre 2021 639.183 639,1 orthe totsl eXpendibj￿. £629,155 was unrestncted (2021.. £441.9221 arKI £57,209 was restric*￿ (2021: £197.2611. 14

Jneti¢s Notes to tho financkl statements For the year ended 31 December2022 Not In¢omei{•xwnartuY•}for thp year thrth9rgino 1{UE¢fvyJl". 2022 2021 Depreoaknn IT￿￿[￿JelrteyAM1t￿￿3feeS net ofVAT 2,637 2.8 2,857 2022 2021 199,1O¥ 183,634 16,32S 4,190 4383 220￿4$ 3.149 The ioial empkry88 irKthig EnTpbsWs NIC ofthÈ key man4Èmont wp)ftnel were £82.091. No (arFty W&E pavj LY r￿e1%￿l any tr￿effi$ from grnpbwNent itri the Laiity i lh¢ year 12tr21'. £ni nerfherwetetsy ex[n￿￿u[￿ th8yw{2021." En￿). Stall 2022 2021 No. The tharfta>￿ a)mrwy ftL¥n ¢xXrfft￿ffi lay a5 1 is c*kMaNè #rvj aprI￿d br purwses. 10 Tanglbktllx￿ assets Futrmturg & Equiprrent Totsl C￿t Atthè 3tartof the yeor Addrth)fps In yeer D￿poS￿& in ygar Atthe end otthe 6.912 12272 6.e12 11.808 7T720 Atthe start ofthe >Yer Charue fortheyear Iminated on d1¥rtx￿l Atthe (5fihe)ear 6912 4,672 2.637 11,784 2.837 7.509 14,421 Mpt bDok valup Atth• ènd ofth• y•ar 4.299 Atth& year 488 488 15

Jnetl¢8 Notes to the financlal stat8nnts For thg year en¢¢ 31 Decemtsr 2022 11 Dgbtors 2022 2021 137 11.588 10,ODD 6,355 Otrer grdntilebity¥ 4.556 3.677 1.668 29.747 12 creditors: dLthitt tsThky•ar 202? 2021 Trade ￿￿￿t( TaY3t￿n and #K￿lse￿rity PenÈron 12iB$8 fj.440 1.075 78,%D 21,121 3,OOQ 65.3&6 4.3SO 834 Acuuals 92,5Q2 17,562 180.F23 2022 2021 atthè tw'rrthig oftt Amount E￿ISÈd tts income in th@Y￿r Amtsuni dèferrÉd In￿ yoai Balan& ai the end DfthÈ yo¥ 17,56Z 117,5621 3.000 3.000 50,DDD 15D.(W} 17.562 17562 Defe￿e￿ irwne tBptesents grsftts 1Èc￿J at ￿ em Oftho tax yoarwThth entiroty forthe purpo88 ofrpiecb drt 8ftw the 202142 ￿ar. The dètsi Ofyi￿￿1[ t rwtsj fft the surwuenl Ar￿￿#1¥ of netasseis ttstn fvnds 13 fu funds fundg Tary1b￿ nxed assets Netcurwtatssets Netass•ts atlhe end oftr*)wr 4399 4,299 217.036 18.000 TDtal fvnos fun(Js bJntt$ Jn Tsngiue f￿￿ 0gSÈts Nètcutrentassets Nelas88ts #tthe gnd 0ftnes￿r 12 343 343 3373 57.209 57 6,239 16

Jnptic Notos to the financial ststements For the ear endad 31 D￿mber 2022 f4101 MovemeF)ts ITr luryl¥ In¢oming 0￿￿OIng Atthe stsrtol rEsr￿￿e & Yesourwd At th• •nd Ihe year g8irA & IoBsoS Trangfvrs of tho year BRCA PrDie£t 57309 16.1 1572091 Yo,000 57209 Unmtricted fvttdÈ.' tk9nat8d funds 2,825 Q.8251 11343 8Z&972 629.1551 686.364 2Wd.335 203.$35 Toial unwtrictsdlyDd5 141bl Miwernents ￿K￿lr￿j Oulwg At the losses Tronsfus ofthe yoar tt￿ye￿[ BRCA Priy GENEius 57.209 156.$781 57209 103.OfM) 1197 261) 151,239 T(2I reited fiJr t31 103.ow 197261 151,339 57.209 Unr2wifd futth." Desv)npted fund (kn￿al funds 32 243.487 (2.8571 I439.￿) 12,8251 12,343 359.16D Totsl unre8trKtrJ fiJr 243.519 359.160 151.239 9,518 To lund a to deveknp kay Inthation [ESOU￿￿5 and taise a￿a￿￿e$S Triqliry io BRCA as50oatsd canows amorvj the'at IrEertr¥sal risk. In the UKwilh the aim ofllTrprwry the awess. dwosts and mAw8ment of these (xnc81s. 1S LtyEI 8tatu¥ of thechllrity Tne a L¥Jrnpany limited by guarantee ÈrTd has r) snaTB car￿1. m￿l￿r is IMt4e to ¢(xthbute a Sum n(* ekreèying t1 n the event ofthe tharfty teUYJ up. 16 17