OpenCharities

This text was generated using OCR and may contain errors. Check the original PDF to see the document submitted to the regulator.

2023-12-31-accounts

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Trustees’ report and financial statements

For year ended

31 December 2023

Registered in England No. 2155347 Registered Charity No. 800579

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

About the CCDC

Delivering our vision

Key product releases

Quicklinks See next page for full contents

Financial review

Structure and governance

Looking to the future

Administrative details

Independent auditors’ report

2

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Contents

Contents
About the CCDC 6
We shape the future of structural science 8 e the future of structural science 8
What we do 8
What makes us different? 9
Supportingthe community 10
Our strategy: Advancing structural
chemistryworldwide 10
Our strategic aims, vision, and mission 11
Our values 12
Public Benefits 13
Delivering our vision 14
Scientific innovation 20
CCDC studentships 20
Impact of the CCDC in worldwide
research 21
Key product releases 22
Foundational area 24
Solid form area 25
Lookingforward 26
Structure and governance 36 Structure and governance 36
Governance 39
Nomination Committee 40
Audit Committee 40
Remuneration Committee 40
Risk Committee 40
Management and staffing 41
Remuneration Policy 41
Risk management 42
Goingconcern 44
Looking to the future 46
Administrative details 52
Auditors, Bank, Solicitors and
Investment advisers 53
Trustees 53
Chief Executive Officer 53
Company& CharityRegistration 53
Statement of Trustees’ responsibilities 55
Financial review 28
Principal funding 30
Expenditure 32
Investmentpolicy 34
Reserves 35
Independent auditors'
report 56
Consolidated statement of financial
activities 62
Charitybalance sheet 64
Consolidated statement of cashflows 65
Notes to the financial statements 66

Trustees’ report and financial statements for year ended 31st December 2023

3

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Trustees’ report and financial statements for year ended 31st December 2023

4

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Trustees’ report and financial statements for year ended 31st December 2023

5

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

----- Start of picture text -----
About the
CCDC
----- End of picture text -----

----- Start of picture text -----
6 Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

Back to contents

----- Start of picture text -----
Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B
----- End of picture text -----

----- Start of picture text -----


Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

7

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

About the CCDC and its purpose

We shape the future of structural science

What we do

CCDC are world-leading experts in high-quality structural chemistry data, scientific software, and knowledge & insights for materials and life science research, drug discovery science, pharmaceutical development and application.

We specialize in the collation, curation, preservation, dissemination and application of scientific structural data for use in biopharmaceutical discovery and manufacturing, materials development, and research and education.

We compile and distribute the Cambridge Structural Database (CSD), a certified trusted database of fully curated and enhanced organic and metal-organic high-quality structures, used by researchers across the globe, and available both on-premise or in the cloud.

Our cutting-edge scientific software empowers scientists and researchers to extract invaluable insights and knowledge from the vast dataset, informing and accelerating their research and development, thereby driving new innovations and discoveries.

8 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

What makes us different?

HIgh-quality, trusted data ~~a~~

Each structure within the CSD undergoes extensive validation and cross-checking via automated workflows (utilising machine learning techniques and semantic rules) and through manual curation by our expert chemists, crystallographers and data analysts. This means you can trust that the data within the CSD is accurate, consistent, and of highest quality (a key requirement for good machine learning models and deploying AI-based methods successfully).

Furthermore, we enrich the data with bibliographic, chemical, and physical property information and a range of additional metadata. This adds further value and scope to the original structural data and enables both scientists and machines (e.g. new AI-based algorithms) to interpret the structures in a chemically meaningful way.

Managing this data so that it is available and secure is a critical part how CCDC ensures the CSD remains an important global data repository. We continue to invest in multiple layers of cyber-security, work with 3rd parties to test our systems and software for vulnerabilities and run ongoing cyber-security training with all staff.

Unique data ~~a~~

We enable researchers to publish data that otherwise would have remained unpublished, confidential, and unknown directly through the CSD. The CSD therefore contains data that isn’t available anywhere else in the world.

Intelligent software and expertise as

Our in-house software experts keep up to date with the latest developments in global data and software standards, applying their knowledge and expertise to develop robust systems that provide researchers with the tools to access, search, visualize, and meaningfully interpret the data within the CSD.

Knowledge en

Using a novel application of existing and new algorithms and methods to explore the highquality structural data and physicochemical properties within the CSD, we can extract new scientific insights to advance structural science worldwide, and assist in the making of new discoveries.

Trustees’ report and financial statements for year ended 31st December 2023

9

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

About the CCDC and its purpose

Supporting the community

We are committed to the advancement of chemistry for the public benefit, serving the global chemistry community by helping to address our users’ structural, physical, and chemical challenges through high-quality data, cutting-edge software, and specialist knowledge & expertise.

We offer a selection of products and services free of charge for the benefit of the scientific community. Our services cover a wide range of crystallographic tools — from data collection, validation, advanced searching, and visualization to teaching, research, and analysis.

Our strategy: Advancing structural chemistry worldwide

The main objective of the not-for-profit Charity is the general advancement and promotion of the science of chemistry and crystallography in all its branches for the public benefit.

The CCDC’s strategy is to continue collecting, curating, making available, and learning from structural chemistry data on a deeper, faster, and more interlinked level, as well as gradually more in line with open and FAIR (Findable, Accessible, Interoperable, Reusable) requirements. We have set a goal to go from one million to over two million structures over the next five years. Both more complex molecules (for example, proteins, macromolecules, metal-organic frameworks, and polymers) and non-experimental data or theoretically calculated data (for example, crystal structure prediction landscapes and structures with density-functional theory with recalculated hydrogen positions) will be stored. This data growth, the inclusion of new types of structures, and the increased level of interlinking is based on a new, continuously evolving, foundational database architecture that is much more scalable and futureproof. It allows us to keep on building a more interconnected structural science universe. Through updated editorial workflows and improved interactions with the wider scientific community and all depositors, we will capture and add more fields and metadata, as well

as physicochemical data. We endeavour to lead structural scientific research by working with all our in-house scientists, our research partners, commercial clients, and our international academic network. We will continue to develop helpful partnerships and alliances, furthering our cause, as well as scaling up our global distribution network. By developing and supporting CCDC’s industry-leading, scientific software suites and underlying high-quality and highprecision data, we will find new insights using novel techniques in machine learning and artificial intelligence. To this end, the CCDC is constructing a distributed and heterogeneous, high-compute infrastructure using all our existing computational power and then optimising and expanding these compute capabilities. This system will use other cloud computing resources to expand elastically as needed for more scientific computations.

Furthermore, through our global education and outreach, we will promote the power of structural science and train up the next generation of scientists and CCDC champions, ensuring better adoption of CCDC’s software suites and data within both academia and industry. Our CCDC champions network has grown to 25 people in 26 countries around the world – with many activities being carried out by those champions.

Trustees’ report and financial statements for year ended 31st December 2023

10

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Our strategic aims, vision, and mission

Leading structural scientific research ee

Creating and supporting industry leading software

Trustees’ report and financial statements for year ended 31st December 2023

11

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

About the CCDC and its purpose

Our values

At the CCDC, our mission is to shape the future of structural science by accelerating the discovery and development of new medicines and chemical products by promoting collaboration across academia and industry and by inspiring a new generation of structural chemists globally through outreach and education. We have nine core values underpinning everything we do to ensure we achieve our mission. The CCDC and its staff live by the following nine principles and value statements, and we have further embedded these values in the ways we work across all levels and functions of the organisation.

Community

We serve the global scientific communities for the public benefit.

Passion

We are enthusiastic about the services we provide and committed to the people we help.

Integrity

We act with integrity and communicate honestly and transparently.

Quality

We are experts in our field, producing trusted resources for our community and customers.

Collaboration

We work together and engage positively with others to achieve our goals.

Innovation

We push boundaries in all that we do and creatively advance understanding.

Agility

We act in flexible and efficient ways, with a sense of urgency and turn around requests as fast as possible without compromise to quality.

Customer Centricity

We provide a high-quality product and service with an excellent customer experience.

Diversity

We believe in diversity and inclusion, and we work to create a culture of belonging, where everyone is welcome, valued and respected.

Trustees’ report and financial statements for year ended 31st December 2023

12

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Public Benefits

The CCDC Board of Trustees holds in high regard the principle of public benefit and requires the CEO, the executive team, the wider senior leadership, and staff of the CCDC to pursue policies that demonstrate this. At its quarterly meetings, the Board of Trustees reviews ongoing charitable activities to ensure consistency with our charitable objectives. The Board of Trustees is aware of the Charity Commission’s guidance on public benefit and has had regard to it in determining the Charity’s aims and objectives and in the way it carries out its activities.

Photo of the attendees of the event at Downing College, Cambridge in 2015 to celebrate 50 years of the CSD. In the photo are the speakers, invited attendees, CCDC staff past and present, CCDC Trustees and the founder of the CSD Dr Olga Kennard.

Trustees’ report and financial statements for year ending 31st December 2023

13

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

----- Start of picture text -----
Delivering
our vision
----- End of picture text -----

14 Trustees’ report and financial statements for year ended 31st December 2023

Back to contents

----- Start of picture text -----
Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B
----- End of picture text -----

----- Start of picture text -----


Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

15

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Delivering our vision

During 2023, the Cambridge Structural Database (CSD) grew by 5% to over 1.25 million entries. During the year, four data releases were delivered through our desktop software and users could access up to the minute data updates through our online services such as Access Structures and WebCSD.

The 1.25 millionth milestone was reached in August 2023 with the electron diffraction structure of ibuprofen, published in Acta Cryst. A by L. Palatinus et al. (CSD Entry: JEKNOC16). The CSD continues to be a global community resource, and in 2023 alone deposited structures were determined by over 12,000 different crystallographers from around 100 different countries. With over 80% of structures in the CSD published in associated scientific articles the CCDC continued to expand its partnerships with publishers and 2023 saw the launch of a new workflow with Open Research Europe. This partnership supports researchers in fulfilling open data policies and helps to ensure more crystal structure data is findable, accessible, interoperable, and reusable (FAIR). The ability for researchers to publish directly through the CSD for free as CSD Communications helped support the amount of new crystal structures shared with the community in 2023.

With 60K structures validated into the CSD in 2023, CSD Communications continued to be the number one way to share structural data, accounting for over 10% of the new structures added during the year. In total over 6K additional structures were shared in this way during the year and they now account for over 57K of the entries in the CSD. The CCDC also supported researchers worldwide to help convert historical entries into the CSD from hardcopy, printed information.

With the continued growth of the database, the CCDC expanded its capabilities to update and enhance existing entries in the CSD. During 2023 over 191,000 existing entries (up from 54,000 in 2022) were improved to feature additional data such as bioactivity, natural source, oxidation states, labelled radical species and polymorphs and improved clarity in the melting point and recrystallization data

fields. Our portfolio of targeted collections of data, known as CSD Subsets were also updated in line with our data releases. These targeted datasets help to provide easy access to highly relevant structures that can be hard to locate with simple searches and are convenient starting points for further research and analysis. The subsets are often created with external collaborators who are experts in their fields. So, users benefit from both internal and external knowledge.

The founder of the CSD, Dr Olga Kennard was awarded the Gregori Aminoff Prize in 2023 for her pioneering work to establish molecular structure databases. Sadly, Dr Olga Kennard passed away in March 2023 at the age of 98, but the Gregori Aminoff Prize Symposium was an opportunity to celebrate her amazing legacy with the scientific community.

To maintain the CSD’s reputation as a trusted data repository in 2023 the CCDC re-applied for CoreTrustSeal accreditation to stay certified as a global trusted data repository. The re-certification process saw us review and update our scientific data preservation policy. During the year we also extended and increased the automation of our data integrity checks on incoming data and worked closely with publishers when any data integrity issues were identified. Data integrity checks and partnerships with publishers are key in minimizing the impact of the increased use of papermills in academic publishing. The community were kept informed of our response to papermills through articles and a dedicated FAQ. By the end of 2023 a total of 738 structures had been retracted from the database.

The value of one million plus crystal structures continued to be the subject of hundreds of articles worldwide, including 11 that were

Trustees’ report and financial statements

16

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents VAN

Fig 1 Chart showing the growth of the Cambridge Structural Database.

showcased through our Tools in Action series. In 2023, approximately one thousand peerreviewed articles by researchers in academia and industry cited the CSD reference paper which equates to nearly 3 new citations a day. This highlights the breadth of applications made possible with this resource.

During the year, the CCDC continued to support our global scientific community. We participated in many international conferences both in-person and virtually, including the Pan African Conference on Crystallography (PCCr), the British Crystallographic Association (BCA) meeting, the Pistoia Alliance Spring Conference, the American Crystallographic Association (ACA) meeting, BioIT World conference, both the Spring and Fall American Chemical Society (ACS) meetings, the Slovenian-Croatian Crystallographic Meeting (SCCM), the International Conference on Crystal Growth and Epitaxy (ICCGE), the International Union of Crystallography (IUCr) Congress, AI in

Chemistry Symposium, the International Symposium on Industrial Crystallisation (ISIC), the Crystal Forms Meeting, the Belgian Crystallography Symposium, the Brazilian Crystallographic Association meeting, the Research Data Alliance (RDA) meeting and International Data Week. Alongside participating in international conferences, the CCDC delivered over twenty workshops at crystallographic schools and training events worldwide (either in-person or virtually) including at the PCCr, the SCCM, the IUCr Congress, the Durham Intensive Teaching School, the Hot Topics in Contemporary Crystallography (HTCC) School, the Canadian Chemical Crystallography Workshop (CCCW), the Erice School, the ACA Summer School, European Crystallography School, the Kenyan School on Powder Diffraction and the Malaysian Crystallographic Association workshop.

Trustees’ report and financial statements for year ended 31st December 2023

17

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Delivering our vision

During 2023, the CCDC also hosted six free virtual workshops over two series in spring and autumn. These online training sessions were well attended from all over the world, with attendees from over 60 countries represented (up from over 55 in 2022) throughout the year. These sessions each had around 300 registrations and 100 attendees, which was comparable to 2022. In total through our in-person and on-line tutored sessions and with the help of our CSD Champions we delivered training to over 1,400 people, which was an increase of over 60% compared to 2022.

Fig 2 Map showing where people attended live from for our Spring 2023 series of CCDC Virtual Workshops. Lighter to darker shades of blue represent a growing number of sessions where at least one attendee joined live from that country.

As well as supporting and hosting virtual global events, the CCDC established and enriched the educational resources we provide. These resources include guided step by step workshops, how-to- videos and social media software tips to help users explore the CSD and associated software. New online training courses were added to CSDU, our collection of free on-demand modules, with content comparable to that of live workshops and with a completion certificate to be earned at the end. These on-demand courses

go beyond our self-guided workshops with focussed modules that include bite-sized videos, demonstrations, guided hands-on exercises and tests. They help to increase the accessibility of our training courses across different time-zones, competing schedules and different preferred learning styles of our user base. All the modules are free to access and are designed to help train scientists in the value of structural data for research and education.

To help inspire the next generation of structural scientists, 2023 saw the return of CCDC hosting an in-person event at the Cambridge Festival with our Crystal Adventures activity. Participants of all ages hunted for the structures of everyday compounds, viewed crystal growth in real time under the microscope, matched proteins to ligands with a card game, and built crystal structure models. All of the resources for this event were also shared on our website and a number of the activities were used at the

CCDC interactive activity station at the CrystalA-Con public event in Melbourne, Australia in August. In addition to the CCDC activities 2023 saw the delivery of the first ever CCDC Engagement Grants which were designed to support others to produce resources or activities to increase schools and public engagement in crystallography and structural science. In total six projects were completed in 2023 and the outputs from the projects were shared through our website.

Trustees’ report and financial statements for year ended 31st December 2023

18

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents TAN

Seven new projects were also funded in 2023, ranging from activities to support crystallographers in African society to projects to engage a new generation of scientists through the use of Lego. The outputs of these grants will be shared in 2024.

As well as supporting scientists in our community so they can contribute to our mission to advance structural science for the public benefit, the CCDC supported early-stage structural scientists at 19 events worldwide through the provision of early career prizes and sponsorship. In 2023 CCDC also hosted a cohort of 4 students over the summer months for paid placements. The placements involved typing up legacy data, enrichments to the CSD as well as the creation of educational resources. The 2023 cohort were all undergraduate students in the UK. These projects helped the students familiarize themselves with a range of scientific software and learn about the importance of good data management practices before resuming their academic studies. Alongside these paid summer placements, the CCDC also hosted school age work experience students helping them to learn more about what a career in science

entails.

In 2023, the CCDC supported 4 new PhD students with CCDC funding and supervision and all the CCDC sponsored PhD students (around 15 in total) were invited to speak at the 2023 CCDC Research Day at the CCDC in Cambridge in June. Alongside PhD sponsorship the CCDC supported one Masters student from the University of Munster and hosted Professor Izabela Madura from the University of Warsaw on a sabbatical.

We continued to promote our Frank H. Allen International Research and Education (FAIRE) programme that provides free access to the CSD and associated software to scientists in eligible countries who may not otherwise have access. In 2023, ten new institutions were awarded a campus-wide CSD license under the FAIRE programme, taking the total number of active FAIRE holders to 42. The initiative supported researchers to publish over 40 publications in 2023 and since their launch in 2017 over 100 scientific articles in primary research journals have been published.

Fig 3 Map showing where our FAIRE programme was used in 2023. Lighter to darker shades represent a growing number of FAIRE holders ranging from one to four.

Trustees’ report and financial statements for year ended 31st December 2023 19

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Delivering our vision

Scientific innovation

CCDC has continued to innovate in 2023. We have built a team that is now researching better ways to take advantage of the coming of age of crystal structure prediction (CSP). Said team has built applications targeting the storage, retrieval, usage and standardization of information derived from CSP studies. This has been augmented by work on the publication of the results of the CCDC CSP blind test. The blind test highlighted the complexity of structural prediction, and the complexity of experimental interpretation of results.

Going forwards from the CCDC blind test, the CCDC is supporting the COST (European Cooperation in Science and Technology) project 'BEST-CSP' (Bringing Experiment and Simulation Together in Crystal Structure Prediction), which seeks to generate a community benchmark dataset of experimental properties for pharmaceutically relevant polymorphic systems, in order to train and test new and innovative computational approaches.

On the discovery side of the organization, the team has worked towards developing methods for prediction of PROTAC complex formation; an area that is growing in discovery sciences. We collaborated with Intel on developing better workflows for curating proteins too. We’ve also been active in functional materials, building a team to start to research areas where the CSD could be more impactful.

Fig 4 Chart showing the worldwide distribution of citation counts (according to Web of Science) for papers citing at least one of the key CCDC reference papers published in 2023. Borders of FAIRE countries are highlighted, showing that CCDC’s FAIRE program to ensure access to data is impactful, allowing scientists in these countries to undertake interesting scientific studies.

CCDC studentships

CCDC has a vibrant studentship program. We are associated with 4 doctoral training centres across the United Kingdom, and sponsor students in projects across a broad range of scientific domains. We currently support 19 students worldwide. The themes of study include the use of the CCDC’s software and services in neglected disease projects, research into development of methods for protein-ligand docking, analysis of solid form and particle surfaces, fundamental research into the role of entropy in crystal formation and even extend into making use of crystallographic data in aiding development of chiral synthetic routes.

Trustees’ report and financial statements for year ended 31st December 2023

20

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Fig 5 Chart showing the distribution of topics (according to Web of Science) for papers citing at least one of the key reference papers that CCDC has published.

----- Start of picture text -----
Physics Atomic
Molecular Chemical
Pharmacology Pharmacy
Chemistry Organic
Chemistry Medicinal 3% [2%]
3% Chemistry
Mulitidisciplinary
4% 20%
Biochemistry
Molecular Biology
7%
Materials Science
Mulitidisciplinary 7% Distribution of
paper topics Other Categories
19%
9%
Chemistry Physical
10%
16%
Chemistry Inorganic Nuclear
Crystallography
----- End of picture text -----

Impact of the CCDC in worldwide research

The CCDC’s software and services continue to have impact in research across the world. In 2023, some 2,360 papers were published that cite at least one of the key reference papers that CCDC has published. Most of these papers are examples of use of the software or data in academic and industrial research. In these papers, at least one author was affiliated with an institution from 107 different countries according to Web of Science. Publications from 142 countries worldwide have featured the CSD across all publications in Web of Science.

It is worth highlighting that nearly a quarter of these publications come from FAIRE-eligible countries. In 2023 we featured 4 new countries, including Laos and Uganda.

While the vast majority of citing publications in Web of Science fall into the Web of Science category of ‘Chemistry Multidisciplinary’ or ‘Crystallography’, 90 publication categories were featured in this year’s set of published papers. Intriguingly, 1 paper that is listed as relevant to Zoology features in the list (a study of inhibitors of MAPK3, relevant for potential therapies for Leishmaniasis (https://link.springer.com/article/10.1007/s11686-023-00659-0 ) and another marked as “Medicine Legal” - a study of cobalt (II) thiocyanates, which are relevant to forensic tests for cocaine (https://onlinelibrary.wiley.com/doi/10.1111/1556-4029.15403).

Trustees’ report and financial statements for year ended 31st December 2023

21

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

----- Start of picture text -----
Key product
releases
----- End of picture text -----

22 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

----- Start of picture text -----


Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

23

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Key product releases

across our 2023 saw five major product launches desktop and on-site web platforms, plus three minor launches providing data updates to our customers through our desktop platform. We also had continual smaller updates across our live public web platforms.

Impactful advances have been delivered to our community across all aspects of the CCDC product portfolio this year, with the prioritization of the key areas closely supported by active engagement across all customer segments. Major highlights for 2023 include the launch of our new installation and update experience, as well as the first launch of an important new product component within CSD-Discovery - Macromolecule Hub.

Foundational area

The desktop installation and update system used across our whole portfolio has been completely redesigned to provide a smoother and simpler experience for our customers, and this has been reflected with positive feedback from our user community. We also improved our licensing system to allow greater flexibility in delivering new offerings for industrial customers, such as CSD Landscape Generator and CSD Conformer Generator now being available independently as add-ons.

A focus in 2023 has been our journey to translate functionality from our predominantly desktop-based portfolio towards a predominantly web-based portfolio in the future. We have put in place a Design System to ensure greater consistency and better user experience across our web platform, as well as building towards the first release of our new web platform which will happen in early 2024. This new web platform will be extensible to include not just the expanded advanced search functionality, but eventually all the key capabilities across the CCDC portfolio in the future.

We launched two new areas of functionality in Mercury and the CSD Python API supporting our CSD-Community and CSD-Core users. The new Pore Analyser component available in Mercury and the CSD Python API provides additional information on void volume, surface area and porosity for researchers investigating porous materials. We have also improved the way that we handle disordered structures when loading CIFs into CCDC software, including visualizing the different disorder models and visualizing the contacts and voids for each disorder model.

Trustees’ report and financial statements for year ended 31st December 2023

24

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

. Discovery & integrations area

In the Discovery & Integrations area, which covers the CSD-Discovery product suite and our CSD Python API, we introduced or improved several areas across our platforms. We introduced the new CSD-Discovery component Macromolecule Hub which is a capability within our On-Site web platform for industrial customers and allows the searching on protein binding sites from the PDB, alongside CSD data in one secure, online platform. The torsions sampled by GOLD during docking have also been improved including re-built and enhanced torsion distributions using latest Cambridge Structural Database (CSD), and users can also now use SMARTs to define torsion patterns.

We significantly extended the read and write compatibility for the key file format, mmCIF, across our CSD-Discovery software. Finally, we included a range of new interoperability improvements including embedding support for the IUPAC International Chemical Identifier (InChI) in our portfolio, introducing stereochemistry search capabilities in our CSD Python API, and adding the ability to import and export ChemDraw files.

Solid form area

The Solid Form area covers three solid form-focused product suites - CSD-Materials, CSDParticle, and CSD-Theory. To support solid form reporting and research, we have extended the CSD Python API to cover more of the CSD-Materials suite, including parts of the Solvate Analyser and Hydrate Analyser components, plus improvements to Hydrogen Bond Propensity, and Hydrogen Bond Statistics in the CSD Python API. In CSD-Theory, we also introduced new Landscape Search functionality to our On-Site web platform, allowing users to search for structures within Crystal Structure Prediction (CSP) landscapes.

Trustees’ report and financial statements for year ended 31st December 2023

25

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Key product releases

Looking forward

We continue to prioritize and plan growth of the value that we are delivering to our customers across all aspects of our portfolio in 2024. We will be continuing to increase the investment in the CSD-Discovery product suite in the next year, with the proportional development investment in this area growing each year from 2021 to 2023 and expected to grow again in 2024.

Focus areas in 2024 across our whole portfolio will be user experience in general, plus an even stronger focus on transitioning key capabilities from our desktop interfaces to our new and growing web platform, Lattice, which will have its first global launch in 2024. Finally, we will be growing the professional services offerings in our portfolio, with a greater emphasis on these in the future.

Foundation

Discovery & Integrations

8 Candidate

Solid Form

26 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

8 Flexible Text/Numeric Searching in Web Platform 8 Combined Cell, Formula & Element Searching 8 User Preferences and Query Storage 8 Incremental Data Updates; Export Entries in Web Platform

CSD- P article

Trustees’ report and financial statements for year ending 31st December 2022

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

----- Start of picture text -----
Financial
review
----- End of picture text -----

28 Trustees’ report and financial statements for year ended 31st December 2023

Back to contents

----- Start of picture text -----
Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B
----- End of picture text -----

----- Start of picture text -----


Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

29

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B Financial review

Principal funding

The CCDC’s principal funds arise from the subscription fee to the CSD and its associated scientific software. Its subscribers are academic research institutions from around the globe and industrial companies, mainly within the pharmaceutical and biotech sectors and growing into other sectors such as agrochemistry and the chemical industry. The annual contributions requested from the worldwide academic community are significantly discounted as compared to the contributions requested from industrial subscribers, and special consideration is given to academic users with financial need in historically underrepresented nations. CCDC sets income from academic institutions at a level required to maintain the CSD data content. Income from non-academic users meets the costs of developing the database,

----- Start of picture text -----
2% 0%
5%
93%
2023 Revenue
from all sources
£9.7m
----- End of picture text -----

enterprise architecture, and related software. It enables the CCDC to invest in relevant scientific methods and applications’ research and development. The CCDC received government grants for specific projects (Restricted income) during 2023. It also received donations from its trading subsidiary, CCDC Services Ltd, under a Deed of Covenant. The CCDC holds an investment portfolio from which it receives dividends that are reinvested starting from 2023. The charity does not yet seek to raise funds from third parties by way of donations.

A breakdown of the revenue can be seen below:

Revenue continued to grow in 2023. User retention rate remains high. Coupled with

Subscription fees Trading Income Investment Restricted Income

Trustees' report and financial statements for year ending 31st December 2023

30

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

----- Start of picture text -----
Total Revenue
£10m
9,742,212
£9m
8,438,275
£8m
£7m
£6m — ow Subscription fees
TT Trading Income
-
£5m
oT Investment
£4m _ cy Restricted Income
£3m
—
£2m
£1m
lc
2022 2023
----- End of picture text -----

new subscribers, 2023 saw a 15% growth compared to the year before. The total revenue was £9,742,213 (2022: £8,438,275). The growth is primarily gained from subscription fees, as shown from the chart above, while the other revenue streams remained at a similar level as 2022.

of subvention provided is the FAIRE program that provides free access to the CSD to users who may not otherwise have access. Large subsidies are also provided to users who have limited funds. The total monetary value amounted to £466,378 (2022: £359,433k).

The accounting policy for the recognition of free subventions and subsidies as a gift in kind has been reviewed during the year. It was concluded that they did not meet the definition of a gift-in-kind. The primary form

31

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Financial review

Expenditure

The activities undertaken in the year were carried out within the budget approved by the Trustees. All the expenditures were spent for CCDC’s charitable purpose.

The total expenditure before pension adjustment in 2023 was £10,830,436, an increase of 27% on 2022 (£8,494,811).

Direct costs are the costs resulted directly from undertaking the charitable activities, while support costs are the costs incurred to facilitate the activities. Direct Costs increased 20% in 2023 from £7,058,838 to £8,474,130. It was largely due to increases in headcount, costs related to attending scientific conferences and software development outsourcing. Support costs also increased by 59%, recruitm e nt fees related to increase in headcount and exceptional professional fees contributed to the increase.

Total expenditure

----- Start of picture text -----
229,761
£11m
£10m
2,126,545
£9m 98,463 Grant costs
Support costs
£8m
1,337,510 Direct costs
£7m
£6m
£5m
8,474,130
£4m
7,058,838
£3m
£2m
£1m
2022 2023
----- End of picture text -----

Trustees’ report and financial statements for year ended 31st December 2023

32

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Staff Costs

Staff costs remain the largest expenditure for the CCDC. The total staff number for the Group increased from 102 to 114, between 1 January and 31 December 2023. Total staff costs in 2023 were £7,878,070 (2022: £6,900,740), an increase of 14%. By the end of the year, we had filled most of the open positions, added six extra headcounts to the Business Development department and four in Science function. This enables us to produce more resources, focus on the science strategy, improve our products in meeting user requirements and to reach out to a wider scientific community.

Pension Costs

USS is a multi-employer defined benefit scheme in which most of CCDC’s staff participate. Given the mutual nature of the scheme, it is not possible to identify individual employer’s share of assets and liabilities. The employers should account for the plan as if it were a defined contribution plan. The result of 2023 valuation taken on 31 March 2023 shows the value of the assets exceeding the value of the liabilities on a technical provision basis. The funding ratio level at the valuation date was 111%. This means that contribution to deficit recovery is no longer required. The provision of £2,896,332 is released at the year end. This contributes to the increase of the total funds for the year.

Other operating costs

The costs in maintenance of scientific equipment, including software and hardware, was £450,257 in 2023, an increase of 32% from 2022 (£342,139). The way of working has changed since 2020. CCDC adopted a hybrid working model, supporting staff to continue working remotely. We invested heavily into a new database architecture, collaborative working tools, cyber security, hardware and software. Costs for software have seen higher increases than inflation lately. We are confident that these investments will improve operational efficiency, meet the demand of our users by providing a flexible licensing system, and enable us to reach out to potential users more widely.

Travel resumed in 2023 to pre Covid level. We attended many scientific meetings during the year to engage and connect with the user community, delivered workshops in different parts of the world. £282,580 were spent in 2023 on attending, sponsoring virtual events and other marketing activities, compared to £215,795 in 2022. This enables us to support and engage with the user community more widely and easily.

The grants for sponsoring research students were £229,761 this year (2022: £98,463), an increase of 133%. We sponsored four new students at two UK universities during 2023 as planned. We are currently co-sponsoring 15 students (2022: 13) from 8 UK universities and 1 Italian university.

The CCDC holds an investment portfolio that is managed by Newton Investment Management. It produced an unrealized gain of £373,852 (2022: loss £499,017). This brought the overall financial performance of the CCDC to a surplus of £2,259,348 in 2023 (2022: surplus £1,833,270).

Trustees’ report and financial statements for year ended 31st December 2023

33

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Financial review

Investment policy

Since 1987, CCDC has looked to build up its reserves to provide financial stability and to enable it to fund its research and development activities. The primary objective of the investment policy is to preserve the capital and income in the investment portfolio from inflation.

In 2015, the Board of Trustees reviewed the investment policy. As a result, Newton Investment Management Ltd were appointed as our investment managers and the monies were moved from the incumbent Investment Manager and invested into Newton Growth and Income Fund for Charities.

The investment policy sets no specific ethical constraints on the investment portfolio. However, the portfolio should be invested in a socially responsible manner and the investment manager of the portfolio is expected to consider environmental, social, and governance (ESG) issues in their investment analysis and decision-making process, engaging with company management where appropriate.

It is the practice that the investment advisers attend regular meetings of the Board of Trustees and report on the progress of the fund, and of the CCDC’s investment into it. Detailed written reports are produced on a quarterly basis that value the portfolio and record its respective performance statistics. An integral part of the regular meetings is a detailed discussion on the content of the report with particular reference to the performance aspect. The table below shows the fund’s performance in the last five years.

The Executive Team at the CCDC review monthly reports from the investment managers. The Trustees continue to review the performance of the investment portfolio on a half-yearly basis. A more formal independent review of the investment manager and investment policy will be carried out at least every five years or more frequently if the circumstances require. An independent review was carried out during 2020. The Board were satisfied with the performance of Newton Growth & Income Fund for Charities. It was decided to continue investing with Newton.

Despite producing a positive return, the Fund’s more cautious positioning ensured that it did not fully keep pace with the broad rally in financial assets. The Fund underperformed slightly against benchmark in 2023. The Board made the decision to reinvest the dividends in November 2022. The switch of fund from Income class to Accumulation class was implemented in January 2023. During the year £135,395 were reinvested (2022: £0). The value of the portfolio was £6,879,874 at the end of the year, representing an unrealized gain of £373,862 (2022: loss £499,017)

34 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents TAN

Reserves

CCDC’s Reserves Policy is to maintain sufficient levels of reserves to enable normal operating activities to continue over a period of at least six months should a shortfall in income occur; the policy should take account of potential risks and contingencies that may arise from time to time. CCDC’s Reserves Policy requires the retention of income sufficient to encompass:

At the end of 2023, CCDC’s free reserve was £5,735k (2022: £3,452k). This is equivalent to approximately 6 months of operating costs, 50% of 2024 budgeted costs. Our present position is:

----- Start of picture text -----
||| |---|---| |31 Dec 2023| |Unrestricted Reserves|£9,251k| |Designated Funds| |Fixed Asset Fund|£2,294k| |Research and Development Fund|£173k| |Sponsorship and Outreach Fund|£41k| |Pension provision Fund|£908k| |Sustainability Fund|£100k| |Free Reserves|£5,735k|

----- End of picture text -----

----- Start of picture text -----
Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B
Structure and
governance
----- End of picture text -----

----- Start of picture text -----
36 Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

----- Start of picture text -----


Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

37

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Structure, management, and governance

CCDC was incorporated as a Company Limited by Guarantee on 18 August 1987. It has no share capital and is a registered charity. The guarantee of each member is £1. The governing documents are the Articles of Association of the company (as amended May 2023).

In addition to CCDC, the charity operates the following subsidiaries:

CCDC Services Ltd (formerly CCDC Software Ltd.)

A wholly owned trading subsidiary of the CCDC. It was established in 1998 to deliver bespoke software development as necessary to meet the requirements of CCDC’s charitable status. Since 2015, its trading activities have evolved towards professional services from software development. 2019 was the first year when all its revenues arose from professional services.

The CCDC’s Board of Trustees and the Director of CCDC Software Ltd approved of the name change to best reflect the trading activities of the company in May 2019. The name change was officially registered with Companies House on 28th July 2019. The company is located at the same address as CCDC. The Directors of CCDC Services Limited consist of two Trustees of the CCDC, an external Non-Executive Director, and the Chief Executive Officer of the CCDC. The Directors meet at least once a year. The Directors of the CCDC Services Limited do not receive remuneration for their service.

An executive summary report of the key activities and performance of the entity is provided into the main Board of Trustees meeting.

CCDC Inc.

A wholly-owned service subsidiary of the CCDC incorporated in the state of New Jersey in September 2013, with legal address of One Boston Place, Suite 2600, Boston, MA 02108, USA. The fully virtual team spans from coast to coast, and works collaboratively with global colleagues, users, and the wider scientific community to advance the overall group mission across the Americas. They support Education & Outreach, Customer Support, Customer Success, Research, Partnerships, Business Development, and Marketing in the region on behalf of the parent company.

Trustees’ report and financial statements for year ended 31st December 2023

38

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Governance

The Charity is governed by the Board of Trustees who delegate operational management to the Chief Executive Officer (CEO), supported by an Executive Leadership Team (ELT) covering all functions of the organisation, as well as an eXtended Management Team (XMT), various operational-level decision-making bodies such as the Product Management Board (PMB), Technical Review Board (TRB), Data Review Board (DRB), Science Research and Innovation Board (SRIB), Project Management Office (PMO) and the new Discovery Portfolio Board (DPB). Other cross-functional teams or groups, such as the Wellbeing Committee and Culture Team, also exist.

In accordance with governing documents, potential Trustees are appointed by the Board based on recommendations by the Nominations Committee and on their specific skills, location, and diversity. Potential Trustees are sent an induction pack covering their obligations under Charity and Company Law, Articles of Association, Memorandum of Association and Codes of Practice, company policies, and a non-disclosure agreement. Potential Trustees are invited to attend Board meetings as observers. After that, the Board of Trustees and the individual consider their suitability to act as a Trustee ahead of their formal acceptance to the post at the Annual General Meeting (AGM). Upon acceptance and appointment, Trustees receive an induction to the business, which covers key aspects of the organization, its operations, and salient Health and Safety information.

The Board of Trustees usually meets at the CCDC Cambridge UK office twice per annum in May and November, with two further virtual meetings in February and August. Working to a standing agenda, the meetings with the CEO and the ELT provide oversight on the performance and progress of the Charity in line with strategy. Progress reports from all functions are presented to the Board at these meetings from the corresponding executive team members. In addition, the Board also receives monthly management account reports from the CEO and produced by CCDC finance, which include the financial performance, the investment performance and cash balances. The opportunity for all staff to interact with the Trustees is always encouraged and was specifically addressed as part of the on-site meetings. All staff members have the option to ask questions in quarterly Q&A sessions at All-Staff meetings, where some trustees are usually present as well.

In addition to the Board meetings, the Board members hold regular, quarterly, telephone update calls with the CEO to address any matters arising from the meetings in a timely manner, to address any issues that need action, or to discuss trends and any matters of interest to the advancement of the charity. In special cases, extra joint calls were convened as needed.

During 2023, meetings of the Board Committees, Nomination, Audit, Risk, and Remuneration were held in accordance with their terms of reference.

Trustees’ report and financial statements for year ended 31st December 2023

39

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Structure, management, and governance

Nomination Committee

The purpose of the Nominations Committee is primarily to ensure that:

Audit Committee

The purpose of the Audit Committee is to ensure the Charity’s annual accounts, budgets, forecasts, and plans are reflected accurately by management accounts and other financial reports presented to them by the finance team.

Remuneration Committee

The purpose of the Remuneration Committee is to ensure that:

Risk Committee

The purpose of the Risk Committee is primarily to ensure that:

The CCDC also has two wholly owned subsidiaries, CCDC Inc. and CCDC Services Limited with each holding one Board meeting per year with their Directors in April.

Trustees’ report and financial statements for year ended 31st December 2023

40

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Management and staffing

The day-to-day management of the CCDC is delegated by the Board of Trustees to the CEO and operational management is supported by the ELT and other managers who, in 2023, were:

----- Start of picture text -----
||| |---|---| |Juergen Harter|Chief Executive Officer| |Suzanna Ward|Head of Data and Community| |Susan Reutzel-Edens|Head of Science (Resigned Feb 2023)| |Juergen Harter|Interim Head of Science| |Jonathan Betts|Head of Commercial| |James Ellis|Head of Operations and Deputy Director| |Bing-Bing Waterman|Head of Finance| |Maggie Brown|Head of Human Resources and Organisational Design|

----- End of picture text -----

These individuals are the key management personnel. They provide reports for the Board of Trustees in support of governance of the Charity and attend Board of Trustees meetings to present operational reports, to position papers on topics of interest, and to regularly cover the centre’s strategy.

Remuneration Policy

The Board of Trustees give their time freely and no Trustees received remuneration in the year. Details of Trustees’ expenses are disclosed in Note 10 to the accounts. The Board of Trustees appoint the CEO who has executive function of conducting the day to day affairs and administration of the Company in accordance with the policy and directions from time to time of the Trustees. The CEO is supported by key management personnel. The pay of the senior staff is reviewed annually and increased in accordance with the company pay policy, which is applicable to all CCDC staff and approved by the Board of Trustees as part of the budget approval process. Furthermore, the Remuneration Committee oversees any of the recommended salary changes, or any other changes to the organisation’s pay policy and discusses trends in line with up-to-date benchmarking data provided by HR.

Trustees’ report and financial statements for year ended 31st December 2023 ,

41

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Structure, management, and governance

Risk management

The CCDC maintains a register of key risks to the organisation, which covers the following areas:

Risk Register entries detail the likelihood and impact of risks occurring, the steps the organisation takes to mitigate these and areas where further action is required.

The Trustees have oversight of risks facing the organisation through the Board Risk Committee, which reviews the Risk Register at least once a year. Membership of the committee is kept under review. Day to day management of the risk register resides with the Head of Operations.

Key risks and mitigation measures are summarised in the table below:

----- Start of picture text -----
||| |---|---| |Threat type|Measure in place| |Succession planning; salaries are reviewed and| |benchmarked annually; overall attractive benefit package;| |Inadequate Staffing|staff development opportunities.| |Recruitment; staff recruited where necessary (subject to| |budget constraints)| |Our good standing within the crystallography community| |rests on the quality of our data, its accessibility and our| |outreach activities. We continue to invest in the scale| |Reputational Damage|and quality of our scientific data, software products,| |and professional services. Additional community| |communications were used in 2023 to address risks arising| |from attempts at systematic data fraud.| |We have a formal relationship with the University of| |University of Cambridge| |Cambridge and are known as a University Partner Institute;| |Relationship|this agreement was renewed for 5 years in 2021.| |We monitor machine access to our data and work with| |Artificial Intelligence (AI)|users to ensure appropriate licences are in place for any| |party wishing to use AI/Machine Learning on the CSD.| |as competitive threat|Mathematical models are already part of our software| |products.|

----- End of picture text -----

Trustees’ report and financial statements for year ended 31st December 2023

42

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Threat type
Measure in place
PT		 Threat type
Measure in place
PT
Revenue below budget Revenues are reviewed monthly along with the sales
pipeline and historical data to give a clear and early insight
into financial performance. In 2023, we continued to invest
in our Commercial team as we seek to increase revenue.
We plan to diversify our revenue sources through grant
income and have set targets for 2024.
Internal and external fraud risks are countered by defined
Financial Fraud processes requiring dual authorization (e.g. payments),
ongoing training (e.g. phishing message awareness) and
insurance policies.
Changes in Foreign We operate foreign currency bank accounts to avoid using
spot-rate currency conversions into pounds sterling. We
Exchange Rates also operate a US subsidiary that enables some US dollar
costs to be managed alongside revenue in US dollars.
Increasing pension costs Employee and employer contributions have increased in
recent years to address deficits in valuations.
Our income and expenditure are well matched. Further,
Insufficient funds from
investment		 our professional investment provider is reviewed every 5
years, with monthly reports on performance. The fund is
designated in the same currency as the majority of our
costs, with US$ holdings at a similar level to our US$ costs.
Inability to generate
revenue from Intellectual
Property		 We aim to ensure that our data services offer unique value
and comply with community expectations regarding data
stewardship. We use licensing authentication software to
reduce the impact of pirated software.
Trustee board meetings are quarterly, with committee
Governance and meetings as required to focus on particular topics, plus a
Scientific Advisory Board (SAB). We maintain appropriate
Compliance knowledge and skills to ensure compliance with our
obligations e.g. Charity Commission requirements, GDPR,
health and safety etc.
Continuous availability of IT systems is critical to our global
organization. We have dedicated facilities for our servers,
monitor access to our services and have implemented
cyber security training and systems. We also use 3rd
parties to assess our systems and identify improvements.
Information Technology We have increased our use of Cloud-based systems to
avoid being solely dependent on our own facilities and
ensure that critical assets are appropriately backed up. We
have various incident response plans to help re-establish
services and benchmark ourselves against independent
standards.
Buildings and Core
Infrastructure		 We have an active programme of building maintenance
to ensure our facilities remain fit for purpose, with service
contracts and out of hours monitoring.

Trustees’ report and financial statements for year ended 31st December 2023

43

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Structure, management, and governance

Going concern

As the COVID-19 pandemic fades into history, environment, and we are global in nature as we have come to appreciate how this episode an organization. CCDC’s productivity remains helped create a more resilient CCDC that high and we are very agile and dynamic could continue to grow and adapt as other in how we deliver our digital products and geopolitical events also buffered the global services, to all geographies and time zones. economy. All businesses have been affected in one way or another, whether directly or We are committed to do all we can to support indirectly. CCDC is no exception to this. The our staff and ensure they are adequately CCDC’s Board of Trustees and executive trained and upskilled. We provided necessary management team have been working equipment for the further optimization hard to ensure CCDC as a global of home working, allowing reduced data repository and world-class and flexible working hours to research institute, is run in support staff with personal a sustainable fashion as a commitments. Managers UK-based not-for-profit frequently checked in with we are charity. CCDC’s business staff for their wellbeing and model is diverse. Our mental health. In 2023 we continuing to users are spread across have implemented a new academic research grow our revenue workplace well-being institutions and and have visibility framework, along with the large pharmaceutical of a healthy sales establishment of workplace companies as well as well-being champions. more recently, many new pipeline We will continue to deploy biotechs. The database helpful and supportive and its associated software activities, touching eight key e products and services are dimensions of wellbeing. distributed and digitally delivered globally, to over 80 countries worldwide We are closely monitoring our financial and growing. We rely primarily on renewal position by continuous review and timely income (approximately 90%) from a core of reforecasting. subscribers who have continued to access the database over the long term (for decades). The CCDC has a healthy cash balance in the As this is needed for their research, they bank, which is easily accessible. We do not are likely to continue to renew year-onanticipate needing to withdraw from the year. The database has become an integral investment fund in 2024. part of research and business operations for such users, and, as it is digital, it can be We maintain confidence in the sustainability remotely operated and used. Because of of the CCDC’s business operations for the long this, its continued use is not necessarily term. Given the nature of CCDC’s business dependent on people getting into their labs model, revenues for the year appear to or research institutions. In the last couple of remain robust. Continued productivity driven years, we have invested heavily into more by improved operational efficiencies and digital transformation and IT infrastructure CCDC’s secure liquid asset holdings makes that have enabled staff to work remotely to us confident that CCDC will overcome the become as efficient as working from the hardships brought on by challenges like rising office. The products and services we provide inflation, the cost-of-living crisis, and new can be delivered electronically. We have built geopolitical tensions. up excellent hybrid/flexible/remote working capabilities accompanied by a good work Heightened pressure to find novel

Heightened pressure to find novel

Trustees’ report and financial statements for year ended 31st December 2023

44

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

therapeutics faster than ever in fields like in silico drug design & discovery, pharmaceutical development & manufacturing, and databased structural research may lead to increased demand for CCDC’s products and services. This is especially true for the field of artificial intelligence (AI), where new advances mean companies are eager to leverage highquality data—like the Cambridge Structural Database (CSD)—in their algorithms and models (e.g. machine learning and deep learning / neural nets). This field of AI is moving at a very fast pace – and is receiving huge amounts of investment.

information from their homes. Between our online educational resources and digital-first software offerings, we are ready to meet the evolving needs of the academic scientific community.

Similarly, students and teachers of structural chemistry seeking at-home, online education solutions present new opportunities for CCDC’s education and outreach efforts. Even as research professors have returned to their labs at universities, it is likely they will continue to appreciate flexible educational materials and being able to run and access

Trustees’ report and financial statements for year ended 31st December 2023

45

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

----- Start of picture text -----
Looking to
the future
----- End of picture text -----

----- Start of picture text -----
Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

46

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

----- Start of picture text -----


Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

47

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Looking to the future

Looking into the mid-term future (two to three years), the CCDC will endeavour to grow our modern, more user-friendly, and adaptive website, with more web-based tools to improve the user experience of our software and data solutions. Over 2023, we have worked with an agency to design, build, and launch improved UX/UI (user experience/user interfaces) of our desktop applications. We have also started to explore how our expert project management can help us deliver more effectively through the use of business units that bring together teams working on the full life cycle of our product offer (from idea to product retirement). We will seek to implement this in 2024.

The CCDC is fortunate to have an excellent scientific advisory board (SAB). The constituency of the SAB was drawn from our existing user base with scientists who have demonstrated track records in their respective fields along with an interest in applying crystallographic knowledge. Over 2023, we have reflected what else will be needed to continue to work with and further optimize the membership and operational running of the SAB. Usually the SAB members are tasked with recommending, evaluating, and reviewing scientific choices and proposals as to areas to target for future development at CCDC—thereby influencing and driving our scientific strategy. We are evolving this setup to see how we can make this more interactive, and ensuring that all our diverse scientific areas are regularly and adequately covered by world experts, from both industry and academic, commercial and non-commercial backgrounds.

Our Operations function has a clear purpose to enable us to define and start delivering against objectives that will improve the effectiveness of our systems/processes for staff and end-users. Operations will continue to drive operational efficiencies and help us reach higher levels of automation over time in all of CCDC’s functions. To give the whole organization the clarity of where to focus and prioritize, we have further developed our Enterprise Balanced Scorecard (EBSC). This tool sets out the key goals for the organization. Objectives at an individual and team level are linked to these EBSC goals to help everyone understand how they can contribute to our purpose-driven organization. This scorecard currently has 4 perspectives (Financial,

Trustees’ report and financial statements for year ended 31st December 2023

48

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

External, Internal and People) and we are considering a 5th perspective (Charity) for 2024. In terms of process efficiency, we are embracing the world of AI beyond our scientific work too. For instance, we are evaluating AI enabled-tools for software development and quality checking. We believe that AI technology will deliver significant process efficiencies in the coming years This will be an important factor in how we continue to grow the organization in a sustainable way.

The trusted quality of our offering remains a key component of CCDC’s offer. As such we continue to invest in the security of our systems and the integrity of our data. For instance, in 2023 we are working towards the UK Government’s Cyber Essentials cyber

security standard and we have planned infrastructure upgrades for 2024 to improve the speed, efficiency and security of data systems. This should provide benefits for all users of our systems, including our internal Science function who require improved computational resources for more theoretical model development and various scientific computations to solve interesting problems.

To build upon the CSD’s reputation as a trusted data repository we have re-applied for our Core Trust Seal accreditation and implemented various improved data quality checks. These are important for combatting the increased use of paper-mills in academic publishing which have the effect of distorting the evidence base if left unchecked.

The value of the CSD is increasingly understood by ventures using AI-backed technologies. Our licencing terms can support the development of data models for commercial application and ensure a revenue stream back to CCDC. This stake in future data models is important for helping CCDC to fund the development of the CSD and other associated charitable activities.

Operations will also continue to adopt best-practice agile software development, investing in new roles to allow this approach to be better realized, keeping our architectural approach under review and utilising 3rd parties where it is most efficient to do so. For example, we will use a 3rd party to augment the capacity of our software development team in a tight recruitment market. Such approaches are intended to help scale our not-for-profit charity.

We will continue to run the CCDC in value creation mode in order to achieve more of our charitable aims, turning the CCDC into a more agile organization with improved branding and raising awareness of our unique selling points and value proposition: a winning combination of high-quality data, excellent science, cutting-edge software, and vast expertise. The CCDC will continue to target revenue growth as a mechanism to deliver a connected structural data universe. We will continue to support existing and new customers across the biopharmaceutical, chemistry, and biotech sectors as well as other industries with a new drive to move into functional and advanced materials.

We will widen our reach, increase user engagement and customer centricity, and enable this growth by further growing the commercial function, the science and data functions. New initiatives in marketing, product & services management, channel management, partnerships and alliances, and service delivery will all play a role to create more value.

Trustees’ report and financial statements for year ended 31st December 2023

49

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Looking to the future

Any generated surplus from the resulting growth will be reinvested in advancing science, data accessibility, and utility; improving our products and services experiences (UX/UI); growing education and outreach efforts globally; and optimizing and scaling up through our skilled people, systems, and processes. This is done with the goal of serving our end users and the wider international scientific community in the best and most sustainable way over the coming years.

Structural science (structural chemistry and biology) has a crucial role to play in battling human and animal diseases. As a community, we need to be versatile and innovative in our approaches to ensure rapid response, and new scientific progress based on knowledge/data-driven insights. In silico drug design and manufacturing methods as well as digitally advanced materials design will have an important role to play. We believe a digitalfirst approach that saves time and resources on the experimental phase will become increasingly important in the coming years. This will drive a need for intuitive and user-friendly solutions that use trusted data and methods to provide quick and accurate results. CCDC is the “go-to” partner for structural science innovation, and we look forward to providing those solutions to identify and mitigate risks—from early-phase drug discovery through development and manufacturing.

We believe a digital-first approach that saves time and resources on the experimental phase will become increasingly important in the coming years.

The world post Covid-19 has evolved towards more remote working or a mixed model, with regular hybrid ways of working. This is a great opportunity for the CCDC to push more digital ways of working since our teams have adapted to the model very well. We intend to further pioneer a digital experience by leading the way with high-quality data and scientific software that is accessible from anywhere in the world via the cloud, and a stronger and more seamless end user experience. These new practices and methods will underpin future ways of working for the research community, academia (e.g., remote teaching and virtual education at scale), the biopharmaceutical industry, and other domains that have a clear and ongoing need for structural chemistry. CCDC will help to shape this future while staying true to our vision and mission to globally advance structural science based on high-quality, trusted big data and software—reaching an ever-growing end-user community.

50 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Trustees’ report and financial statements for year ended 31st December 2023 51

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Administrative details

52

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Trustees

Dr Dave Martinsen Professor Alessia Bacchi Professor Jonathan M Goodman, Chair Professor John P Overington (Resigned May 2023)

Dr Nigel Pitchford Professor Susan Bourne, Vice Chair Dr Ola Engkvist

Dr Ye Li Professor Jennifer Martin (Appointed August 2023)

Chief Executive Officer

Dr Juergen Harter

Company & Charity Registration

Company registered number 02155347 Charity registered number 800579 Registered office 12 Union Road, Cambridge CB2 1EZ

Auditors, Bank, Solicitors and Investment advisers

Independent auditors

Peters Elworthy & Moore Chartered Accountants Salisbury House Station Road Cambridge CB1 2LA

Bankers

Barclays Bank Plc Cambridge CB2 3AA

Lloyds Bank PO Box 1000 Andover BX1 1LT

Solicitors

HCR Hewitsons 50-60 Station Road Cambridge CB1 2JH5

Investment Advisers

Newton Investment Management Limited 160 Queen Victoria Street London EC4V 4LA

53

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Statement of Trustees’ responsibilities

Trustees’ report and financial statements for year ended 31st December 2023

54

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Statement of Trustees’ responsibilities

The Trustees (who are also the directors of the Charity for the purposes of company law) are responsible for preparing the Trustees’ Report including the Strategic Report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

Company law requires the Trustees to prepare financial statements for each financial year. Under company law, the Trustees must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the Group and the Charity and of their incoming resources and application of resources, including their income and expenditure, for that period. In preparing these financial statements, the Trustees are required to:

The Trustees are responsible for keeping adequate accounting records that are sufficient to show and explain the Group and the Charity's transactions and disclose with reasonable accuracy at any time the financial position of the Group and the Charity and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the Group and the Charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

Approved by order of the members of the board of Trustees and signed on its behalf by:

Professor Susan Bourne Chair of the Board of Trustees Date: 10 July 2024

Trustees’ report and financial statements for year ended 31st December 2023

55

----- Start of picture text -----
Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B
Independent
auditors'
report
56 Trustees’ report and financial statements for year ended 31st December 2023
----- End of picture text -----

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Peters Elworthy & Moore Chartered Accountants   Trustees’ report and financial statements for year ended 31st December 2023

57

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

INDEPENDENT AUDITORS' REPORT TO THE MEMBERS OF THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE

OPINION

We have audited the financial statements of The Cambridge Crystallographic Data Centre (the 'parent charitable company') and its subsidiaries (the 'group') for the year ended 31 December 2023 which comprise the Consolidated Statement of Financial Activities, the Consolidated Balance Sheet, the Charity Balance Sheet, the Consolidated Statement of Cash Flows and the related notes, including a summary of significant accounting policies. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including Financial Reporting Standard 102 'The Financial Reporting Standard applicable in the UK and Republic of Ireland' (United Kingdom Generally Accepted Accounting Practice).

In our opinion the financial statements:

BASIS FOR OPINION

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the Auditors' responsibilities for the audit of the financial statements section of our report. We are independent of the Group in accordance with the ethical requirements that are relevant to our audit of the financial statements in the United Kingdom, including the Financial Reporting Council's Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

CONCLUSIONS RELATING TO GOING CONCERN

In auditing the financial statements, we have concluded that the Trustee's use of the going concern basis of accounting in the preparation of the financial statements is appropriate.

Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the Group's or the parent charitable company's ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.

Our responsibilities and the responsibilities of the Trustees with respect to going concern are described in the relevant sections of this report.

OTHER INFORMATION

The other information comprises the information included in the Annual Report other than the financial statements and our Auditors' Report thereon. The Trustees are responsible for the other information contained within the Annual Report. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon. Our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the course of the

Page 2

58 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

INDEPENDENT AUDITORS' REPORT TO THE MEMBERS OF THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (CONTINUED)

audit, or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether this gives rise to a material misstatement in the financial statements themselves. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We have nothing to report in this regard.

OPINION ON OTHER MATTERS PRESCRIBED BY THE COMPANIES ACT 2006

In our opinion, based on the work undertaken in the course of the audit:

MATTERS ON WHICH WE ARE REQUIRED TO REPORT BY EXCEPTION

In the light of our knowledge and understanding of the charitable company and its environment obtained in the course of the audit, we have not identified material misstatements in the Trustee's Report including the Strategic Report.

We have nothing to report in respect of the following matters in relation to which Companies Act 2006 requires us to report to you if, in our opinion:

RESPONSIBILITIES OF TRUSTEES

As explained more fully in the Trustee's Responsibilities Statement, the Trustees (who are also the directors of the charitable company for the purposes of company law) are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as the Trustees determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, the Trustees are responsible for assessing the Group's and the parent charitable company's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the Trustees either intend to liquidate the Group or the parent charitable company or to cease operations, or have no realistic alternative but to do so.

AUDITORS' RESPONSIBILITIES FOR THE AUDIT OF THE FINANCIAL STATEMENTS

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an Auditors' Report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in

Trustees’ report and financial statements for year ended 31st December 2023 Page 3 59

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

INDEPENDENT AUDITORS' REPORT TO THE MEMBERS OF THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (CONTINUED)

accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.

Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, including fraud is detailed below:

Our approach to identifying and assessing the risks of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, was as follows:

We assessed the susceptibility of the charitable company’s financial statements to material misstatement, including obtaining an understanding of how fraud might occur, by:

We discussed among the engagement team the opportunities and incentives that may exist within the organisation for fraud and how and where fraud might occur in the financial statements.

To address the risk of fraud through management bias and override of controls, we;

In response to the risk of irregularities and non-compliance with laws and regulations, we designed procedures which included, but were not limited to:

Page 4

60 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

INDEPENDENT AUDITORS' REPORT TO THE MEMBERS OF THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (CONTINUED)

There are inherent limitations in our audit procedures described above. The more removed that laws and regulations are from financial transactions, the less likely it is that we would become aware of non-compliance. Auditing standards also limit the audit procedures required to identify non-compliance with laws and regulations to enquiry of the directors and other management and the inspection of regulatory and legal correspondence, if any.

Material misstatements that arise due to fraud can be harder to detect than those that arise from error as they may involve deliberate concealment or collusion.

A further description of our responsibilities for the audit of the financial statements is located on the Financial Reporting Council's website at: www.frc.org.uk/auditorsresponsibilities. This description forms part of our Auditors' Report.

USE OF OUR REPORT

This report is made solely to the charitable company's members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the charitable company's members those matters we are required to state to them in an Auditors' Report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the charitable company and its members, as a body, for our audit work, for this report, or for the opinions we have formed.

Kathryn Hebden (Senior Statutory Auditor) for and on behalf of Peters Elworthy & Moore Chartered Accountants Statutory Auditors Salisbury House Station Road Cambridge CB1 2LA

Date: 12 July 2024

Trustees’ report and financial statements for year ended 31st December 2023 Page 5 61

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B Consolidated statement of financial activities of Trustees’ responsibilities

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

CONSOLIDATED STATEMENT OF FINANCIAL ACTIVITIES (INCORPORATING INCOME AND EXPENDITURE ACCOUNT) FOR THE YEAR ENDED 31 DECEMBER 2023

Note
INCOME FROM:
Donations and legacies
2
Charitable activities
3
Other trading activities
5
Investments
6
TOTAL INCOME
EXPENDITURE ON:
Charitable activities
8
Other expenditure
7
TOTAL EXPENDITURE
NET INCOME/(EXPENDITURE)
BEFORE NET GAINS/(LOSSES) ON
INVESTMENTS
Net gains/(losses) on investments
13
NET INCOME/(EXPENDITURE)
Transfers between funds
18
NET MOVEMENT IN FUNDS BEFORE
OTHER RECOGNISED
GAINS/(LOSSES)
OTHER RECOGNISED
GAINS/(LOSSES):
Other (losses)/gains
NET MOVEMENT IN FUNDS
RECONCILIATION OF FUNDS:
Total funds brought forward
Net movement in funds
TOTAL FUNDS CARRIED FORWARD		 Unrestricted
funds
2023
£
165
8,994,633
514,516
189,028
9,698,342
10,742,960
(2,992,780)
7,750,180
1,948,162
373,852
2,322,014
(30,111)
2,291,903
(19,061)
2,272,842
6,977,689
2,272,842
9,250,531		 Restricted
funds
2023
£
14,158
29,712
-
-
43,870
87,475
-
87,475
(43,605)
-
(43,605)
30,111
(13,494)
-
(13,494)
20,900
(13,494)
7,406		 Total
funds
2023
£
14,323
9,024,345
514,516
189,028
9,742,212
10,830,435
(2,992,780)
7,837,655
1,904,557
373,852
2,278,409
-
2,278,409
(19,061)
2,259,348
6,998,589
2,259,348
9,257,937		 Total
funds
2022
£
7,150
7,879,430
407,919
143,776
8,438,275
8,494,811
(2,351,229)
6,143,582
2,294,693
(499,017)
1,795,676
-
1,795,676
37,594
1,833,270
5,165,319
1,833,270
6,998,589

The Consolidated Statement of Financial Activities i ncludes all gains and losses recognised in the year. The notes on pages 66 - 99 form part of these financial statements.

Page 6

62 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee) REGISTERED NUMBER: 02155347

CONSOLIDATED BALANCE SHEET AS AT 31 DECEMBER 2023

2023 2022
Note £ £
FIXED ASSETS
Tangible assets 12 2,294,452 2,324,407
Investments 13 6,879,874 6,370,627
9,174,326 8,695,034
CURRENT ASSETS
Debtors 14 3,483,444 2,648,811
Cash at bank and in hand 2,631,111 4,066,542
6,114,555 6,715,353
Creditors: amounts falling due within one
year 15 (5,883,196) (5,323,915)
NET CURRENT ASSETS
TOTAL ASSETS LESS CURRENT		 231,359 1,391,438
LIABILITIES 9,405,685 10,086,472
Creditors: amounts falling due after more
than one year 16 (147,748) (191,551)
Provisions for liabilities 17 - (2,896,332)
TOTAL NET ASSETS 9,257,937 6,998,589
CHARITY FUNDS
Restricted funds 18 7,406 20,900
Unrestricted funds 18 9,250,531 6,977,689
TOTAL FUNDS 9,257,937 6,998,589

The Trustee acknowledge their responsibilities for complying with the requirements of the Act with respect to accounting records and preparation of financial statements.

The financial statements were approved and authorised for issue by the Trustee and signed on their behalf by:

Professor S Bourne Chair of the Board of Trustees

Date: 10 July 2024

The notes on pages 66 to 99 form part of these financial statements.

Trustees’ report and financial statements for year ended 31st December 2023 Page 7 63

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B Charity balance sheet

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee) REGISTERED NUMBER: 02155347

CHARITY BALANCE SHEET AS AT 31 DECEMBER 2023

2023 2022
Note £ £
FIXED ASSETS
Tangible assets 12 2,294,452 2,324,407
Investments 13 7,043,363 6,534,116
9,337,815 8,858,523
CURRENT ASSETS
Debtors 14 3,777,624 3,008,821
Cash at bank and in hand 1,940,014 3,534,240
5,717,638 6,543,061
Creditors: amounts falling due within one
year 15 (5,850,491) (5,515,135)
NET CURRENT LIABILITIES / ASSETS
TOTAL ASSETS LESS CURRENT		 (132,853) 1,027,926
LIABILITIES 9,204,962 9,886,449
Creditors: amounts falling due after more
than one year 16 (147,748) (191,551)
Provisions for liabilities 17 - (2,896,332)
TOTAL NET ASSETS 9,057,214 6,798,566
~~—_~~
CHARITY FUNDS
Restricted funds 18 7,406 20,900
Unrestricted funds 18 9,049,808 6,777,666
TOTAL FUNDS 9,057,214 6,798,566

The Charity's net movement in funds for the year was £2,258,648 (2022 - £1,781,289).

The Trustee acknowledge their responsibilities for complying with the requirements of the Act with respect to accounting records and preparation of financial statements.

The financial statements were approved and authorised for issue by the Trustee and signed on their behalf by:

Professor S Bourne Chair of the Board of Trustees

Date: 10 July 2024

The notes on pages 66 to 99 form part of these financial statements

Page 8

Trustees’ report and financial statements for year ended 31st December 2023

64

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B Consolidated statement of cashflows

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE

(A Company Limited by Guarantee)

CONSOLIDATED STATEMENT OF CASH FLOWS FOR THE YEAR ENDED 31 DECEMBER 2023

Note
CASH FLOWS FROM OPERATING ACTIVITIES
Net cash used in operating activities
20
CASH FLOWS FROM INVESTING ACTIVITIES
Dividends, interests and rents from investments
Proceeds from the sale of intangible assets
Purchase of investments
NET CASH USED IN INVESTING ACTIVITIES
CHANGE IN CASH AND CASH EQUIVALENTS IN THE YEAR
Cash and cash equivalents at the beginning of the year
21
21
CASH AND CASH EQUIVALENTS AT THE END OF THE YEAR		 2023
£
(1,417,284)
189,028
(71,780)
(135,395)
(18,147)
(1,435,431)
4,066,542
2,631,111		 2022
£
944,270
143,776
(436,741)
-
(292,965)
651,305
3,415,237
4,066,542

The notes on pages 66 to 99 form part of these financial statements

Trustees’ report and financial statements for year ended 31st December 2023 Page 9 65

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B Notes to the financial statements

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

1. ACCOUNTING POLICIES

1.1 BASIS OF PREPARATION OF FINANCIAL STATEMENTS

The financial statements have been prepared in accordance with the Charities SORP (FRS 102) - Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019), the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) and the Companies Act 2006.

The Cambridge Crystallographic Data Centre meets the definition of a public benefit entity under FRS 102. Assets and liabilities are initially recognised at historical cost or transaction value unless otherwise stated in the relevant accounting policy.

The Consolidated Statement of Financial Activities (SOFA) and Consolidated Balance Sheet consolidate the financial statements of the Charity and its subsidiary undertakings. The results of the subsidiaries are consolidated on a line by line basis.

1.2 COMPANY STATUS

The company is a company limited by guarantee. The members of the company are the Trustees named on page 53. In the event of the company being wound up, the liability in respect of the guarantee is limited to £1 per member of the company.

1.3 BASIS OF CONSOLIDATION

The Company has taken advantage of the exemption allowed under section 408 of the Companies Act 2006 and has not presented its own Statement of Financial Activities in these financial statements, however, note 18 of the accounts provides the funds movement of the company only.

1.4 GOING CONCERN

The Cambridge Crystallographic Data Centre meets its day to day working capital requirements through the cash it holds and generates. The charity undertakes a regular process of reviewing forecasts and projections to ensure that it has adequate resources for its continued operations and can draw on its investment portfolio to support its planned activities if required.

Management continuously review the trends in the biopharmaceutical market and wider growth trends in the technology and science fields. CCDC’s data and scientific software offerings remain in good demand, and can furthermore help address new trends such as artificial intelligence, and the investments that are going into those efforts. The Trustees have a reasonable expectation that the charity has adequate resources to continue operational existence for at least 12 months from date of approval of the accounts. For this reason, the charity continues to adopt the going concern basis in preparing its financial statements.

Page 10

66 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

1. ACCOUNTING POLICIES (CONTINUED)

1.5 INCOME

All income is recognised once the Charity has entitlement to the income, it is probable that the income will be received and the amount of income receivable can be measured reliably.

Subscription income is recognised over the period to which it relates, with income being received in advance deferred.

Trading income, consisting of software and consultancy advice is recognised as supplied while maintenance and support services are recognised over the period to which they relate.

Interest on funds held on deposit is included when receivable and the amount can be measured reliably by the company; this is normally upon notification of the interest paid or payable by the bank. Dividends are recognised once the dividend had been declared and notification has been received of the dividend due.

Grants are included in the Consolidated Statement of Financial Activities on a receivable basis. The balance of income received for specific purposes but not expended during the period is shown in the relevant funds on the Balance Sheet. Where income is received in advance of entitlement of receipt, its recognition is deferred and included in creditors as deferred income. Where entitlement occurs before income is received, the income is accrued.

1.6 EXPENDITURE

Expenditure is recognised once there is a legal or constructive obligation to transfer economic benefit to a third party, it is probable that a transfer of economic benefits will be required in settlement and the amount of the obligation can be measured reliably.

Support costs are those costs incurred directly in support of expenditure on the objects of the company and include project management carried out at Headquarters. Governance costs are those incurred in connection with administration of the charity and compliance with constitutional and statutory requirements.

Charitable activities and governance costs are costs incurred on the charity''s operations, including support costs and costs relating to the governance of the company apportioned to charitable activities based on staff roles and time.

Grants payable are charged in the year when the offer is made except in those cases where the offer is conditional, such grants being recognised as expenditure when the conditions attaching are fulfilled. Grants offered subject to conditions which have not been met at the year end are noted as a commitment, but not accrued as expenditure.

1.7 FOREIGN CURRENCIES

Monetary assets and liabilities denominated in foreign currencies are translated into sterling at rates of exchange ruling at the balance sheet date.

Transactions in foreign currencies are translated into sterling at the rate ruling on the date of the transaction.

Exchange gains and losses are recognised in the Statement of Financial Activities.

Trustees’ report and financial statements for year ended 31st December 2023 Page 11 67

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

1. ACCOUNTING POLICIES (CONTINUED)

1.8 TAXATION

The Charity is considered to pass the tests set out in Paragraph 1 Schedule 6 of the Finance Act 2010 and therefore it meets the definition of a charitable company for UK corporation tax purposes. Accordingly, the Charity is potentially exempt from taxation in respect of income or capital gains received within categories covered by Chapter 3 Part 11 of the Corporation Tax Act 2010 or Section 256 of the Taxation of Chargeable Gains Act 1992, to the extent that such income or gains are applied exclusively to charitable purposes.

1.9 TANGIBLE FIXED ASSETS AND DEPRECIATION

Tangible fixed assets costing £10,000 or more are capitalised and recognised when future economic benefits are probable and the cost or value of the asset can be measured reliably.

A review for impairment of a fixed asset is carried out if events or changes in circumstances indicate that the carrying value of any fixed asset may not be recoverable. Shortfalls between the carrying value of fixed assets and their recoverable amounts are recognised as impairments. Impairment losses are recognised in the Statement of Financial Activities.

The cost of replacing and upgrading scientific computer equipment is written off as maintenance to scientific equipment in the income and expenditure account.

Assets in the course of construction are included at costs incurred to date. Depreciation on these assets is not charged until they are brought into use.

Tangible fixed assets are carried at cost, net of depreciation and any provision for impairment. Depreciation is provided at rates calculated to write off the cost of fixed assets, less their estimated residual value, over their expected useful lives on the following bases:

1.10 INVESTMENTS

Fixed asset investments are a form of financial instrument and are initially recognised at their transaction cost and subsequently measured at fair value at the Balance Sheet date, unless the value cannot be measured reliably in which case it is measured at cost less impairment. Investment gains and losses, whether realised or unrealised, are combined and presented as ‘Gains/(Losses) on investments’ in the Consolidated Statement of Financial Activities.

Investments in subsidiaries are valued at cost less provision for impairment.

1.11 DEBTORS

Trade and other debtors are recognised at the settlement amount after any trade discount offered. Prepayments are valued at the amount prepaid net of any trade discounts due.

Page 12

Trustees’ report and financial statements for year ended 31st December 2023

68

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

1. ACCOUNTING POLICIES (CONTINUED)

1.12 CASH AT BANK AND IN HAND

Cash at bank and in hand includes cash and short-term highly liquid investments with a short maturity of three months or less from the date of acquisition or opening of the deposit or similar account.

1.13 LIABILITIES AND PROVISIONS

Liabilities are recognised when there is an obligation at the Balance Sheet date as a result of a past event, it is probable that a transfer of economic benefit will be required in settlement, and the amount of the settlement can be estimated reliably.

Liabilities are recognised at the amount that the Charity anticipates it will pay to settle the debt or the amount it has received as advanced payments for the goods or services it must provide.

Provisions are measured at the best estimate of the amounts required to settle the obligation. Where the effect of the time value of money is material, the provision is based on the present value of those amounts, discounted at the pre-tax discount rate that reflects the risks specific to the liability. The unwinding of the discount is recognised in the Consolidated Statement of Financial Activities as a finance cost.

1.14 FINANCIAL INSTRUMENTS

The Charity only has financial assets and financial liabilities of a kind that qualify as basic financial instruments. Basic financial instruments are initially recognised at transaction value and subsequently measured at their settlement value with the exception of bank loans which are subsequently measured at amortised cost using the effective interest method.

1.15 PENSIONS

The Charity participates in the Universities Superannuation Scheme, a defined benefit scheme which is externally funded and contracted out of the State Earnings-related Pension Scheme. The fund is valued every three years by a professionally qualified independent actuary using the projected unit method, the rates of contribution payable being determined by the trustees on the advice of the actuary. In the intervening years, the actuary reviews the progress of the scheme. Pension costs are accounted for over the period during which the Charity benefits from the employees services.

The Charity also participates in the Cambridge University Assistants’ Contributory Pension Scheme (CUACPS) which is a defined benefit scheme. The Charity’s contributions are affected by a surplus or deficiency in the CUACPS but the Charity is unable to identify its share of the underlying assets and liabilities in the Scheme on a consistent and reasonable basis. The Charity therefore accounts for its contributions to the CUACPS as if it were a defined contribution scheme.

The Charity operates a defined contribution plan for its employees. A defined contribution plan is a pension plan under which the Charity pays fixed contributions into a separate entity. Once the contributions have been paid the Charity has no further payment obligations.

The contributions are recognised as an expense in profit or loss when they fall due. Amounts not paid are shown in accruals as a liability in the Balance Sheet. The assets of the plan are held separately from the Charity in independently administered funds.

Trustees’ report and financial statements for year ended 31st December 2023 Page 13 69

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

1. ACCOUNTING POLICIES (CONTINUED)

1.16 FUND ACCOUNTING

General funds are unrestricted funds which are available for use at the discretion of the Trustee in furtherance of the general objectives of the Charity and which have not been designated for other purposes.

Designated funds comprise unrestricted funds that have been set aside by the Trustee for particular purposes. The aim and use of each designated fund is set out in the notes to the financial statements.

Restricted funds are funds which are to be used in accordance with specific restrictions imposed by donors or which have been raised by the Charity for particular purposes. The costs of raising and administering such funds are charged against the specific fund. The aim and use of each restricted fund is set out in the notes to the financial statements.

Investment income, gains and losses are allocated to the appropriate fund.

1.17 CRITICAL ACCOUNTING ESTIMATES AND AREAS OF JUDGEMENT

Estimates and judgements are continually evaluated and are based on historical experience and other factors, including expectations of future events that are believed to be reasonable under the circumstances.

Critical accounting estimates and assumptions:

The Charity makes estimates and assumptions concerning the future. The resulting accounting estimates and assumptions will, by definition, seldom equal the related actual results. The estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities within the next financial year are discussed below.

Critical areas of judgement:

FRS102 makes the distinction between a group pension plan and a multi-employer pension scheme. A group plan consists of a collection of entities under common control typically with a sponsoring employer. A multi-employer scheme is a scheme for entities not under common control and represents (typically) an industry-wide scheme such as that provided by USS. The accounting for a multi-employer scheme where the employer has entered into an agreement with the scheme that determines how the employer will fund a deficit results in the recognition of a liability for the contributions payable that arise from the agreement (to the extent that they relate to the deficit) and the resulting expense is recognised in the Statement of Financial Activities. The Executive Committee are satisfied that the scheme provided by USS meets the definition of a multi-employer scheme and has therefore recognised the discounted fair value of the contractual contributions under the funding plan in existence at the date of approving the financial statements.

Page 14

70 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

2. INCOME FROM DONATIONS AND LEGACIES

Unrestricted
funds
2023
£
Donations
165
Grants
-
165
TOTAL 2022
7,150
INCOME FROM CHARITABLE ACTIVITIES
Unrestricted
funds
2023
£
Scientific Activity - Subscription Fees
8,994,633
TOTAL 2022
7,767,574		 Restricted
funds
2023
£
-
14,158
14,158
-
Restricted
funds
2023
£
29,712
111,856		 Total
funds
2023
£
165
14,158
14,323
7,150
Total
funds
2023
£
9,024,345
7,879,430		 Total
funds
2022
£
7,150
-
7,150
Total
funds
2022
£
7,879,430

3. INCOME FROM CHARITABLE ACTIVITIES

4. TURNOVER

The whole of the turnover is attributable to the principal activites of the Charity.

A geographical split of turnover is disclosed as follows: United Kingdom 21% (2022 - 21%), Other EU 24% (2022 - 26%) and Rest of the World 55% (2022 - 53%).

Trustees’ report and financial statements for year ended 31st December 2023 Page 15 71

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

5. INCOME FROM TRADING ACTIVITIES

Income from non charitable trading activities

Unrestricted
funds
2023
£
Sales
514,516
TOTAL 2022
407,919		 Total
funds
2023
£
514,516
407,919		 Total
funds
2022
£
407,919

The wholly owned trading subsidiary CCDC Services Limited is incorporated in the United Kingdom and pays all of its profits to the charity under a deed of covenant. The summary financial performance of the subsidiary is shown in note 13.

6. INVESTMENT INCOME

Unrestricted
funds
2023
£
Investment income
162,743
Bank & other interest receivable
26,285
189,028
TOTAL 2022
143,776		 Total
funds
2023
£
162,743
26,285
189,028
143,776		 Total
funds
2022
£
142,968
808
143,776

Page 16

Trustees’ report and financial statements for year ended 31st December 2023

72

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

7. OTHER EXPENDITURE

Unrestricted
funds
2023
£
USS pension provision movement (note 23)
(2,992,780)
TOTAL 2022
(2,351,229)		 Total
funds
2023
£
(2,992,780)
(2,351,229)		 Total
funds
2022
£
(2,351,229)

8. ANALYSIS OF EXPENDITURE BY ACTIVITIES

Scientific Activites
TOTAL 2022		 Activities
undertaken
directly
2023
£
8,474,130
7,058,838		 Grant
funding of
activities
2023
£
229,761
98,463		 Support
costs
2023
£
2,126,544
1,337,510		 Total
funds
2023
£
10,830,435
8,494,811		 Total
funds
2022
£
8,494,811

In 2023, restricted expenditure amounted to £87,475 (2022: £193,977) and unrestricted expenditure was £10,742,961 (2022: £8,300,834).

Trustees’ report and financial statements for year ended 31st December 2023 Page 17 73

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

8. ANALYSIS OF EXPENDITURE BY ACTIVITIES (CONTINUED) ANALYSIS OF DIRECT COSTS

Wages and salaries
Attendance at scientific meetings
Legal and other professional fees
Consultants
Maintenance of scientific equipment
Production and distribution costs
Difference on foreign exchange
Staff development		 Total
funds
2023
£
6,957,618
282,580
2,747
517,899
450,257
68,584
117,043
77,402
8,474,130		 Total
funds
2022
£
6,111,848
215,795
10,326
320,545
342,139
74,390
(59,859)
43,654
7,058,838

Page 18

Trustees’ report and financial statements for year ended 31st December 2023

74

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

8. ANALYSIS OF EXPENDITURE BY ACTIVITIES (CONTINUED) ANALYSIS OF SUPPORT COSTS

Staff costs
Depreciation
Consultancy
Telephone and network costs
Recruitment
Legal and other professional fees
Audit and accountancy
Banking costs
Difference on foreign exchange
Insurance
Premises costs
Bad debt expense
IT equipment, software and hardware
General expenses
Staff development
Finance cost of unwinding of discounting
Board meeting costs		 Total
funds
2023
£
920,452
101,734
27,470
15,823
152,186
167,208
73,931
8,919
169,612
33,921
187,484
152
31,240
48,398
51,579
96,448
39,987
2,126,544		 Total
funds
2022
£
788,892
115,031
26,710
14,762
127,787
88,552
67,510
3,967
(311,650)
57,355
158,809
2,114
21,669
40,329
44,992
50,412
40,269
1,337,510
9.
ANALYSIS OF GRANTS
Grants
TOTAL 2022		 Grants to
Institutions
2023
£
229,761
98,463		 Total
funds
2023
£
229,761
98,463		 Total
funds
2022
£
98,463

Trustees’ report and financial statements for year ended 31st December 2023 Page 19 75

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

9. ANALYSIS OF GRANTS (CONTINUED)

The Group has made the following material grants to institutions during the year:

NAME OF INSTITUTION
Durham University
University of Southampton
Polytechnic University of Turin
University of Sheffield
University of Strathclyde
Other grants to institutions		 2023
£
157,500
3,455
-
-
48,125
209,080
20,681
229,761		 2022
£
-
40,000
30,218
500
-
70,718
27,745
98,463

10. AUDITORS' REMUNERATION

2023 2022
£ £
Fees payable to the Charity's auditor for the audit of the Charity's annual
accounts 24,920 23,075
Fees payable to the Charity's auditor in respect of:
All taxation advisory services not included above 6,768 3,708
All non-audit services not included above 16,698 18,455

Page 20

76 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

STAFF COSTS, KEY MANAGEMENT PERSONNEL AND TRUSTEES' REMUNERATION AND 11. EXPENSES

Staff costs were as follows:

Group
Group
2023
2022
£
£
Wages and salaries
6,098,107
5,316,818
Social security costs
630,478
592,600
Other pension costs
1,149,485
991,322
USS pension provision movement (note 24)
(2,992,780)
(2,351,229)
4,885,290
4,549,511
The average number of persons employed by the Charity during the year was
Group
Group
2023
2022
No.
No.
Office and Administration
11
9
Technical
99
89
110
98		 Charity
2023
£
5,409,659
544,082
1,054,920
(2,992,780)
4,015,881
as follows:
Charity
2023
No.
10
91
101		 Charity
2022
£
4,779,505
503,724
939,294
(2,351,229)
3,871,294
Charity
2022
No.
8
82
90

Trustees’ report and financial statements for year ended 31st December 2023 Page 21 77

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

11. STAFF COSTS, KEY MANAGEMENT PERSONNEL AND TRUSTEES' REMUNERATION AND EXPENSES (CONTINUED)

The number of employees whose employee benefits (excluding employer pension costs) exceeded £60,000 was:

Group Group
2023 2022
No. No.
In the band £60,001 - £70,000 12 7
In the band £70,001 - £80,000 10 6
In the band £80,001 - £90,000 5 5
In the band £90,001 - £100,000 3 -
In the band £100,001 - £110,000 1 1
In the band £110,001 - £120,000 3 2
In the band £130,001 - £140,000 1 1
In the band £160,001 - £170,000 1 1

The key management personnel of the charity comprise the trustees, the Chief Executive Officer and the Senior Leadership Management Team. No trustees received any remuneration or benefits in kind from the charity (2022 - £NIL). The total employee benefits of the key management personnel, including employers’ NIC and employers pension of the charity were £1,079,514 (2022 - £1,127,136).

A total of £9,843 (2022 - £9,371) was reimbursed or paid directly to 8 (2022 - 7) trustees in respect of travel and accommodation costs.

Page 22

78 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

12. TANGIBLE FIXED ASSETS

GROUP

COST
At 1 January 2023
Additions
Transfers between classes
Foreign exchange movement
At 31 December 2023
DEPRECIATION
At 1 January 2023
Charge for the year
Foreign exchange movement
At 31 December 2023
NET BOOK VALUE
At 31 December 2023
At 31 December 2022		 Long-term
leasehold
property
£
3,966,255
-
542,662
-
4,508,917
2,234,321
83,847
-
2,318,168
2,190,749
1,731,934		 Fixtures and
fittings
Assets
under
construction
£
£
727,118
542,004
-
71,779
-
(542,662)
(229)
-
726,889
71,121
676,649
-
17,887
-
(229)
-
694,307
-
32,582
71,121
50,469
542,004		 Total
£
5,235,377
71,779
-
(229)
5,306,927
2,910,970
101,734
(229)
3,012,475
2,294,452
2,324,407

Trustees’ report and financial statements for year ended 31st December 2023 Page 23 79

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

12. TANGIBLE FIXED ASSETS (CONTINUED)

CHARITY

COST
At 1 January 2023
Additions
Transfers between classes
At 31 December 2023
DEPRECIATION
At 1 January 2023
Charge for the year
At 31 December 2023
NET BOOK VALUE
At 31 December 2023
At 31 December 2022		 Long-term
leasehold
property
£
3,966,255
-
542,662
4,508,917
2,234,321
83,847
2,318,168
2,190,749
1,731,934		 Fixtures and
fittings
Assets
under
construction
£
£
722,837
542,004
-
71,779
-
(542,662)
722,837
71,121
672,368
-
17,887
-
690,255
-
32,582
71,121
50,469
542,004		 Total
£
5,231,096
71,779
-
5,302,875
2,906,689
101,734
3,008,423
2,294,452
2,324,407

Page 24

Trustees’ report and financial statements for year ended 31st December 2023

80

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

13. FIXED ASSET INVESTMENTS

GROUP
VALUATION
At 1 January 2023
Additions
Revaluations
AT 31 DECEMBER 2023		 Listed
investments
£
6,370,627
135,395
373,852
6,879,874
CHARITY
VALUATION
At 1 January 2023
Additions
Revaluations
AT 31 DECEMBER 2023		 Investments
in
subsidiary
companies
£
163,489
-
-
163,489		 Listed
investments
£
6,370,627
135,395
373,852
6,879,874		 Total
£
6,534,116
135,395
373,852
7,043,363

All the listed fixed asset investments are held in the UK.

All investments are carried at their fair value. Investments in equities and fixed interest securities are all traded in quoted public markets, primarily the London Stock Exchange. Holdings in common investment funds, unit trusts and open-ended investment companies are at bid price. The basis of fair value for quoted investments is equivalent to the market value, using the bid price. Asset sales and purchases are recognised at the date of trade at cost (that is their transaction value).

The Charity does not make use of derivatives and similar complex financial instruments as it takes the view that investments are held for long term growth and annual income.

The Group has no material investment holdings in markets subject to exchange controls or trading restrictions.

Trustees’ report and financial statements for year ended 31st December 2023 Page 25 81

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

13. FIXED ASSET INVESTMENTS (CONTINUED)

PRINCIPAL SUBSIDIARIES

The following were subsidiary undertakings of the Charity:

Names Company Registered office or principal Principal activity
number place of business
CCDC Services Limited 03483374 12 Union Road, Cambridge, CB2 Provision of
1EZ professional
services for digital
drug design and
manufacture, and
advanced training.
CCDC Inc One Boston Place, Suite 2600, Provision of
Boston, MA 02108, United professional
States services for digital
drug design and
manufacture, and
advanced training.
Class of Holding
shares
Ordinary 100%
Capital 100%

The financial results of the subsidiaries for the year were:

Names Income Expenditure Profit for Net assets
£ £ the year £
£
CCDC Services Limited 514,970 (139,083) 375,887 2,118
CCDC Inc 1,014,988 (1,014,288) 700 362,094

Page 26

Trustees’ report and financial statements for year ended 31st December 2023

82

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

14. DEBTORS

Group
Group
2023
2022
£
£
DUE WITHIN ONE YEAR
Trade debtors
2,892,364
2,165,037
Amounts owed by group undertakings
-
-
Other debtors
114,595
29,604
Prepayments and accrued income
476,485
454,170
3,483,444
2,648,811
CREDITORS: AMOUNTS FALLING DUE WITHIN ONE YEAR
Group
Group
2023
2022
£
£
Trade creditors
144,366
126,695
Amounts owed to group undertakings
-
-
Other taxation and social security
218,353
229,828
Other creditors
312,338
127,760
Accruals and deferred income
5,208,139
4,839,632
5,883,196
5,323,915
Group
Group
2023
2022
£
£
Deferred income at 1 January 2023
4,904,595
3,549,573
Resources deferred during the year
5,239,996
4,904,595
Amounts released from previous periods
(4,904,595)
(3,549,573)
5,239,996
4,904,595		 Charity
2023
£
2,755,451
489,276
110,854
422,043
3,777,624
Charity
2023
£
132,287
67,162
200,675
312,338
5,138,029
5,850,491
Charity
2023
£
4,879,595
5,191,138
(4,879,595)
5,191,138		 Charity
2022
£
2,038,805
507,899
29,161
432,956
3,008,821
Charity
2022
£
122,283
260,130
211,356
127,760
4,793,606
5,515,135
Charity
2022
£
3,492,679
4,879,595
(3,492,679)
4,879,595

15. CREDITORS: AMOUNTS FALLING DUE WITHIN ONE YEAR

Deferred income relates to subscriptions received in advance of which £5,092,248 (2022: £4,735,193) relates to amounts due within 1 year and £147,748 (2022: £169,402) relates to amounts due after 1 year.

Trustees’ report and financial statements for year ended 31st December 2023 Page 27 83

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

16. CREDITORS: AMOUNTS FALLING DUE AFTER MORE THAN ONE YEAR

Other creditors
Accruals and deferred income		 Group
2023
£
-
147,748
147,748		 Group
2022
£
22,149
169,402
191,551		 Charity
2023
£
-
147,748
147,748		 Charity
2022
£
22,149
169,402
191,551

17. PROVISIONS

GROUP AND CHARITY

At 1 January 2023
Amounts released		 Pension
deficit
funding
provision
£
2,896,332
(2,896,332)
-

PENSION DEFICIT FUNDING PROVISION

The Charity participates in the University Superannuation Scheme (USS), a multi-employer defined benefit scheme. The 2020 valuation of the scheme showed a shortfall in funding with a funding ration of 83%. The charity made additional contributions to address the funding deficit of the scheme and in accordance with FRS102 provision has been made for the future funding requirement in prior years. However, the 2023 valuation showed an improvement with the value of the assets exceeding the value of the liabilities on a technical provision basis. This means that the scheme has a surplus rather than a deficit. At the valuation date 31 March 2023, the funding level was 111%. Deficit contribution rate changed from 6.3% up to 31 December 2023 to 0% from 1 January 2024. No provision is required for deficit recovery.

Page 28

84 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

18. STATEMENT OF FUNDS STATEMENT OF FUNDS - CURRENT YEAR

UNRESTRICT-
ED FUNDS
DESIGNATED
FUNDS
Fixed Asset
Fund
Research and
Development
Fund
Sponsorship and
Outreach Fund
CSD and
Sustainability
Fund
Pension
Provision Fund
GENERAL
FUNDS
General Funds -
all funds
TOTAL
UNRESTRICT-
ED FUNDS
RESTRICTED
FUNDS
ROYCE grant
Google Ad grant
BioChem
GRAPH		 Balance at 1
January
2023
£
2,324,407
173,406
20,122
100,086
908,000
3,526,021
3,451,668
6,977,689
-
-
20,900		 Income
£
-
-
-
-
-
-
9,698,342
9,698,342
16,214
14,158
13,498		 Expenditure
£
(101,735)
-
(229,177)
-
-
(330,912)
(7,419,268)
(7,750,180)
(46,325)
(14,158)
(26,992)		 Transfers
in/out
£
71,779
-
250,000
-
-
321,779
(351,890)
(30,111)
30,111
-
-		 Gains/
(Losses)
£
-
-
-
-
-
-
354,791
354,791
-
-
-		 Balance at
31
December
2023
£
2,294,451
173,406
40,945
100,086
908,000
3,516,888
5,733,643
9,250,531
-
-
7,406

Trustees’ report and financial statements for year ended 31st December 2023 Page 29 85

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

18. STATEMENT OF FUNDS (CONTINUED) STATEMENT OF FUNDS - CURRENT YEAR (continued)

TOTAL OF
FUNDS		 Balance at 1
January
2023
£
20,900
6,998,589		 Income
£
43,870
9,742,212		 Expenditure
£
(87,475)
(7,837,655)		 Transfers
in/out
£
30,111
-		 Gains/
(Losses)
£
-
354,791		 Balance at
31
December
2023
£
7,406
9,257,937

Page 30

Trustees’ report and financial statements for year ended 31st December 2023

86

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

18. STATEMENT OF FUNDS (CONTINUED) STATEMENT OF FUNDS - PRIOR YEAR

UNRESTRICT-
ED FUNDS
DESIGNATED
FUNDS
Fixed Asset
Fund
Research and
Development
Fund
Sponsorship and
Outreach Fund
CSD and
Sustainability
Fund
Pension
Provision Fund
GENERAL
FUNDS
General Funds
TOTAL
UNRESTRICT-
ED FUNDS
RESTRICTED
FUNDS
DDA Grant
DIDCOM Grant
BioChem
GRAPH		 Balance at
1 January
2022
£
2,002,697
173,406
118,352
100,086
908,000
3,302,541
1,823,611
5,126,152
-
-
39,167		 Income
£
-
-
-
-
-
-
8,326,419
8,326,419
44,137
51,644
16,075		 Expenditure
£
(115,031)
-
(98,230)
-
-
(213,261)
(5,736,344)
(5,949,605)
(73,562)
(86,073)
(34,342)		 Transfers
in/out
£
436,741
-
-
-
-
436,741
(500,595)
(63,854)
29,425
34,429
-		 Gains/
(Losses)
£
-
-
-
-
-
-
(461,423)
(461,423)
-
-
-		 Balance at
31
December
2022
£
2,324,407
173,406
20,122
100,086
908,000
3,526,021
3,451,668
6,977,689
-
-
20,900

Trustees’ report and financial statements for year ended 31st December 2023 Page 31 87

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

18. STATEMENT OF FUNDS (CONTINUED)

STATEMENT OF FUNDS - PRIOR YEAR (CONTINUED)

----- Start of picture text -----
Balance at
Balance at 31
1 January Transfers Gains/ December
2022 Income Expenditure in/out (Losses) 2022
£ £ £ £ £ £
-
39,167 111,856 (193,977) 63,854 20,900
TOTAL OF
-
FUNDS 5,165,319 8,438,275 (6,143,582) (461,423) 6,998,589
----- End of picture text -----

The purpose of funds above are detailed as follows:

DESIGNATED FUNDS:

Fixed Asset Fund: This fund represents the balance of the groups' reserves held as fixed assets. The transfer represents movements to fixed assets in the year.

Research and Development Fund: This fund finances research activities and makes grants for research where general funds are not available for this purpose.

Sponsorship and Outreach Fund: This fund supports the cost of funding studentships worldwide.

CSD and Sustainability Fund: This fund is established to provide support in the event of unexpected legal, legislative or regulatory events which might have a negative effect on the Centre.

Pension Provision Fund: a designated fund set up to provide provision to cover any future deficit in the pension scheme.

RESTRICTED FUNDS:

Google Ad: CCDC receive a Google Ads Grant, as part of Google’s programme to support nonprofits (https://www.google.co.uk/grants/ ). This awards us a monthly sum (max $10,000) to spend on Google advertising, which we use to promote our Access Structures service, training and learning resources, teaching materials, and events — all of which are free resources for the community. We also promote our general about us video using the grant, to raise awareness of the CCDC and our charitable activities as a whole.

BioChemGRAPH: The BioChemGRAPH project aims to establish a collaboration between PDBe, ChEMBL and CCDC to create an easily accessible resource that integrates structural, functional and biochemical annotations of small molecule data into one place. This project will promote interoperability between small molecule resources by implementing common data standards. The project also aims to improve the findability and accessibility of small molecule annotations via uniform data access mechanisms and develop intuitive web components to visualise these valuable data through web interfaces. It will significantly increase the synergies between structural and biochemical data and will lead

Page 32

88 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

to increased understanding of the role of small molecules in biological systems and translational research in a number of areas, including synthetic biology, target validation, and drug development. The project started on 2 November 2020 and will last 36 months. BioChemGRAPH was 80% funded by BBSRC, 20% of the costs will be covered by the general fund.

ROYCE : This project was an effort to augment the crystal structure data within the CSD, with calculated physical property data, of relevance to Organic Semi-Conductor (OSC) design. Following the Q4 2024 data release, researchers will be able to place the results of their own proposed OSC's, within the context of all known OSCs in the CSD; alongside understanding molecular properties such as HOMO-LUMO Gap and singlet state energies, the major barrier to widespread adoption of OSC's is the tuning of crystallographic dependent properties, such as transfer integral and dynamic disorder. This project has delivered a platform for assessing proposed OSC's rapidly. The grant was funded by Henry Royce Institute. It started on 1 October 2023 with a completion date of 29 February 2024.

DDA Grant : The Digital Design Accelerator Platform is an InnovateUK funded project to develop digital risk assessments for pharmaceutical manufacturing processes. A collaboration between innovators, industry, and academia, this 24 month project is intended to build from recent advances in Digital Design methods. It provides us with industrial direction for research and development into Particle Informatics and the new CSD-Particle Suite. The project started on 1 March 2020. The project ended on 31 August 2022.

DIDCOM : The Digital Design of Complex Materials for Formulated Products (DIDCOM-FP) grant was awarded through the UKRI’s Industry Strategy Challenge Fund (ISCF) Manufacturing Made Smarter challenge. It is a collaborative project with industrial partners, that started in July 2020, centred on materials modelling. Our involvement is focused on solid-liquid equilibria and aims to create a database to enable better solubility prediction and solvent selection tools. This project will last 24 months. The project ended on 30 June 2022

Trustees’ report and financial statements for year ended 31st December 2023 Page 33 89

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

19. ANALYSIS OF NET ASSETS BETWEEN FUNDS ANALYSIS OF NET ASSETS BETWEEN FUNDS - CURRENT YEAR

ANALYSIS OF NET ASSETS BETWEEN FUNDS - CURRENT YEAR
Unrestricted
funds
2023
£
Tangible fixed assets
2,294,452
Fixed asset investments
6,879,874
Current assets
6,107,149
Creditors due within one year
(5,883,196)
Creditors due in more than one year
(147,748)
TOTAL
9,250,531
ANALYSIS OF NET ASSETS BETWEEN FUNDS - PRIOR YEAR
Unrestricted
funds
2022
£
Tangible fixed assets
2,324,407
Fixed asset investments
6,370,627
Current assets
6,694,453
Creditors due within one year
(5,323,915)
Creditors due in more than one year
(191,551)
Provisions for liabilities and charges
(2,896,332)
TOTAL
6,977,689		 Restricted
funds
2023
£
-
-
7,406
-
-
7,406
Restricted
funds
2022
£
-
-
20,900
-
-
-
20,900		 Total
funds
2023
£
2,294,452
6,879,874
6,114,555
(5,883,196)
(147,748)
9,257,937
Total
funds
2022
£
2,324,407
6,370,627
6,715,353
(5,323,915)
(191,551)
(2,896,332)
6,998,589
Tangible fixed assets
Fixed asset investments
Current assets
Creditors due within one year
Creditors due in more than one year
Provisions for liabilities and charges
TOTAL

Page 34

90 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

ANALYSIS OF NET ASSETS BETWEEN FUNDS - CHARITY ONLY - CURRENT YEAR

Unrestricted
funds
2023
£
Tangible fixed assets
2,294,452
Fixed asset investments
7,043,363
Current assets
5,716,832
Creditors due within one year
(5,850,491)
Creditors due in more than one year
(147,748)
Provisions for liabilities and charges
(3,457,818)
5,598,590		 Restricted
funds
2023
£
-
-
7,406
-
-
-
7,406		 Total
funds
2023
£
2,294,452
7,043,363
5,724,238
(5,850,491)
(147,748)
(3,457,818)
5,605,996		 Total
funds
2022
£
2,324,407
6,534,116
6,543,061
(5,515,135)
(191,551)
(2,896,332)
6,798,566

ANALYSIS OF NET ASSETS BETWEEN FUNDS - CHARITY ONLY - PRIOR YEAR

Unrestricted
funds
2022
£
Tangible fixed assets
2,324,407
Fixed asset investments
6,534,116
Current assets
6,522,161
Creditors due within one year
(5,515,135)
Creditors due in more than one year
(191,551)
Provisions for liabilities and charges
(2,896,332)
6,777,666		 Restricted
funds
2022
£
-
-
20,900
-
-
-
20,900		 Total
funds
2022
£
2,324,407
6,534,116
6,543,061
(5,515,135)
(191,551)
(2,896,332)
6,798,566

Trustees’ report and financial statements for year ended 31st December 2023 Page 35 91

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

RECONCILIATION OF NET MOVEMENT IN FUNDS TO NET CASH FLOW FROM OPERATING 20. ACTIVITIES

Net income for the year (as per Statement of Financial Activities)
ADJUSTMENTS FOR:
Depreciation charges
Losses / (gains) on investments
Dividends, interests and rents from investments
Increase in debtors
Increase in creditors
Movement in provisions
Movement in foreign exchange reserve
NET CASH PROVIDED BY/(USED IN) OPERATING ACTIVITIES
21.
ANALYSIS OF CASH AND CASH EQUIVALENTS
Cash in hand
TOTAL CASH AND CASH EQUIVALENTS
22.
ANALYSIS OF CHANGES IN NET DEBT
At 1
January
2023
£
Cash at bank and in hand
4,066,542
4,066,542		 Group
2023
£
2,278,409
101,735
(373,852)
(189,028)
(834,633)
515,478
(2,896,332)
(19,061)
(1,417,284)
Group
2023
£
2,631,111
2,631,111
Cash flows
£
(1,435,431)
(1,435,431)		 Group
2022
£
1,795,676
115,031
499,017
(143,776)
(215,734)
1,157,279
(2,300,817)
37,594
944,270
Group
2022
£
4,066,542
4,066,542
At 31
December
2023
£
2,631,111
2,631,111

Page 36

Trustees’ report and financial statements for year ended 31st December 2023

92

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

23. PENSION COMMITMENTS

The Group operates a defined benefit pension scheme.

The Charity’s employees belong to two principal pension schemes, the Universities Superannuation Scheme (USS) and the Cambridge University Assistants’ Contributory Pension Scheme (CUACPS). The total pension cost for the period was £1,142,885 (2022 - £906,175).

In 2022 the Charity added a third pension scheme, a defined contribution scheme. The assets of the scheme are held separately from those of the Company in an independently administered fund. The pension cost charge represents contributions payable by the Company to the fund.

Universities Superannuation Scheme

The Charity participates in the Universities Superannuation Scheme (USS), a defined benefit scheme which is contracted out of the State Second Pension (S2P). The assets of the scheme are held in a separate fund administered by the trustee, Universities Superannuation Scheme Limited.

The 2023 valuation was the seventh valuation for the scheme under the scheme-specific funding regime introduced by the Pensions Act 2004, which requires schemes to have sufficient and appropriate assets to cover their technical provisions. At the valuation date, the value of the assets of the scheme was £73.1 billion and the value of the scheme’s technical provisions was £65.7 billion indicating a surplus of £7.4 billion and a funding ratio of 111%.

The key financial assumptions used in the 2023 valuation are described below. More detail is set out in the Statement of Funding Principles (uss.co.uk/about-us/valuation-and-funding/statement-of-fundingprinciples).

Trustees’ report and financial statements for year ended 31st December 2023 Page 37 93

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

23. PENSION COMMITMENTS (CONTINUED)

Principal actuarial assumptions at the Balance Sheet date (expressed as weighted averages):

At 31 At 31
December December
Discount rate Discount rate 2023
%		 2022
%
Pension increases (CPI) Pension increases (CPI)
5.54 3.33
6 6

Page 38

94 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

23. PENSION COMMITMENTS (CONTINUED)

The current life expectancies on retirement at age 65 are:

At 31 At 31
December December
2023 2022
Years Years
MORTALITY RATES (IN YEARS)
Males currently aged 65 years 24 23.9
Males currently aged 45 years 25.6 25.5
Females currently aged 65 years 26 25.9
Females currently aged 45 years 27.4 27.3

Trustees’ report and financial statements for year ended 31st December 2023 Page 39 95

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

Cambridge University Assistants' Contributory Pension Scheme

The Charity also participates in the Cambridge University Assistants’ Contributory Pension Scheme (CUACPS) which is a defined benefit scheme. The Charity's contributions are affected by a surplus or deficiency in the CUACPS but the Charity is unable to identify its share of the underlying assets and liabilities in the Scheme on a consistent and reasonable basis. The Charity therefore accounts for its contributions to the CUACPS as if it were a defined contribution scheme.

The most recent full actuarial valuation of the CUACPS was carried out as at 31 July 2021 by an independent actuary, Robert Sweet, who is a Fellow of the Institute of Actuaries. He is not an employee or officer of the Charity. The CUACPS is not a closed scheme nor one in which the age profile of the active membership is rising significantly.

The method used in the actuarial valuation as at 31 July 2021 was the Projected Unit funding method. The main assumptions were:

Economic Discount rate: RPI+1.9% Asset return for Recover Plan: RPI +1.9% Rate of Salary increases: 4.5% for 21/22 and then CPI +1.5% thereafter Rate of increases in pensions in payment: - RPI max 12%, min 0% based on yeild curve rates - RPI max 5%, min 0% with appropriate caps and - CPI max 5%, min 0% collars Rate of increases in pensions in deferment: - GMP CPI +1.5% - Pensions in escess of GMP: - RPI BoR yield cruve - CPI RPI - 1% to 2030 and RPI -0.1% from 2031

Assets & Expenses Valuation of assets: Surrender value of the assets Expenses: - Past service 1.0% of the liability excluding expenses - Future service 0.9% of the Pensionable Salary Pension Protection Fund levies: Included in the future service cost expense

Demographic Rate of mortality:

Future Projected Improvements Long Term rates of improvement Additional internal rate of improvement Smoothing factor

115% of S3PMA pension mortaility tables for males and 100% of S3PFA pension mortality tables for females. CMI_2020 1.25%pa 0.25% p.a

7

Assumed Age at Retirement: UNI 1 - Active members - Deferred members UNI 2 & UNI 3 Proportion married Age difference

Males 64, Females 63 Males 62, Females 61 Males 65, Females 65 80% male at age 65 70% female at age 65 Male assumed to be 3 years older than femal spouse

Page 40

96 Trustees’ report and financial statements for year ended 31st December 2023

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

Value of benefits in respect of service on or before 31 July 2018:

Technical Provisions [a] £742,670,000 Market Value of Scheme Assets [b] £708,068,000 Past Service Surplus/(Deficit) [b-a] £34,602,000 Level of Funding of Past Service Benefit [b]/[a] 95%

The Trustee and the University have agreed that Employer contributions should continue at the current rates. The Trustee and the University have also agreed that the Employer will continue to pay additional contributions of £14,595,000 p.a. over the period to 31 July 2023 . The scheme's funding position will be re-examined as at 31 March 2023, using assumptions derived as set out in the Statement of Funding Principles dated 31 October 2022. If the funding level as at that date is below 95% then additional contributions will be payable from 1 August 2023 at the rate of £10,000,000 pa payable until July 2024.

The ongoing overall joint contribution rate for future service benefits, ignoring the past service position, is 12.2% of Pensionable Salaries. The split of this rate is shown below:

Pre 2013 Members paying additional contributions under Rule 45.6

Other pre 2013 Members paying

Post 2013 Members

24. OPERATING LEASE COMMITMENTS

The Group and the Charity had no commitments under non-cancellable operating leases at 31 December 2023.

Trustees’ report and financial statements for year ended 31st December 2023 Page 41 97

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

THE CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE (A Company Limited by Guarantee)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

25. RELATED PARTY TRANSACTIONS

In 2023 the following transactions took place between the Charity and its wholly owned subsidiary CCDC Services Limited:

The provision of management services by the Charity to the company of £113,389 (2022: £93,161). The transfer under deed of covenant of the trading profits of CCDC Services Limited to the Charity of £375,887 (2022: £334,343).

At the year end a balance of £489,276 (2022: £507,889) was owed to the Charity by CCDC Services Limited.

In 2023 the following transactions took place between the Charity and its wholly owned subsidiary CCDC Inc:

The provision of a sales office and related services by the company to the Charity of £1,014,445 (2022: £786,506).

At the year end a balance of £67,162 (2022: £260,130) was due to (2022: owed to) to CCDC Inc by the Charity.

There were no other outstanding balances with related parties as at 31 December 2023 (2022 - £NIL).

Page 42

Trustees’ report and financial statements for year ended 31st December 2023

98

Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B

Back to contents

Trustees’ report and financial statements for year ended 31st December 2023 99

----- Start of picture text -----
Docusign Envelope ID: 8025FFBD-376D-496A-A696-3699A46D110B
----- End of picture text -----

The Cambridge Crystallographic Data Centre

12 Union Road, Cambridge CB2 1EZ United Kingdom

Office: +44 (0)1223 336408 email: hello@ccdc.cam.ac.uk www.ccdc.cam.ac.uk

Registered in England No. 2155347 Registered Charity No. 800579

report design by timbond design