REGISTERED COMPANY NUMBER." 02143917 IEng13nd 3nd W31esl REGISTERED CHARITY NUMBER.. 327493 Twstees. RekK¥t aml Audited Finanual Statements for the Year Ended 31 March 2023 CHILDHOOD EYE CANCER TRUST IA COMPANY LIMITED BY GuARA￿[EEl KnoxCtDpper LLP Chartered AcccAJntsnts and Statutory Auditors 65 Leadenhall Street London EC3A2AD CHILDHOOD EYE CANCER TRUST Contents of the Flnan¢lal Statements for the Year Ended 31 March 2023 Pa RefÈrÈn¢È and Admlnl$tratlvÈ DÈtall$ Trustees RÈ ort 2-21 rt of the Inde endent Auditors 22-24 Statement of Financial Activities 25 Balance Sheet 26 Cash Flow Statement 27 Not85 to the Financial Statements 28-39 CHILDHOOD EYE CANCER TRUST Reference and Administrative Details for the Year Ended 31 March 2023 TRUSTEES lan Ellington-chaimian Gemma 8oggs- T￿aSUrer Lisa Brown EIEabelh Colema ex Brebbia Andrea Bonz8no Matthew Ho Rob Downes Damian Yeo lappointed11.6.221 Michelle B(K)throyd lappointed 30.7.221 COMPANY SECRETARY Rose-marie Sexton REGISTERED OFFICE The Royal London Hospital, VVhite¢hapel Road. London, E1 1FR REGISTERED COMPANY NUMBER 02143917 (England and Waksl REGISTERED CHARrrY NUMBER 327493 INDEPENDENT AUDITORS Knox Cropper LLP. Chartered Accountants and StatLrtory Auditors, 65 Leadenh811 Street, London, EC3A 2AD Page 1 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 Tru5tees' Report for the Year Ended 31 March 2023 The trustees hvho a￿ also directots of the ¢harrty ft>r the purtmtses of the Companies 2006. present their r8POrt wtth the finsnual staternents of the chaiity for the year ended 31 March 2023. Th8 trust88S have adopted the provisions of A(tounts"ng and Reportsng by Chanties.. Statement of Recommended PractiTr applicable to charities preparing theii accounts in accor¢Jance with the Financial RepK)rting Standard applicab￿ in the UK and Republic of Ireland IFRS 1021 leffective 1 JanLJary 20191. Page 2 CHILDHOOD EYE CANCER TRUST IREGISTERED NUMBER= 021439171 OBJECTIVES AND ACTMTIES Objects of the Charity The Childhood Eye Can￿[ Twst is a charity dedicated to helping anyone affeded by retinoblastoma (Rbl. type of eye can￿r that affects babies and young children, mainty under the age of six. We have been supporting families since 1987. Around one child a week is dragnosed with Rb in the UK or 50 a year. It account5 for 3% of childhood cancers in the UK and 10% of cancers in babies under one. Amund 45% of cases are heriiable and this carries with it an increased risk of developing tumours in other parts of the body in laier life. Th8 Charity was originally founded to provide support and information lo those affected by Rb. In 1994 we merged with another charity that was funding ￿ear¢tt projects specificalty related lo Rb. and in 2004 W8 changed our name to the Childh(x)d Eye Cancer Trust. As we grew, so did our aim5 and objective5 and we began lo run tampaigns aimed at raising awareness among health professionals and the public in order lo achieve the eadiest possible diagnosis for ¢hild¢n affected. Our aims are to.. Provide 5UPPOrt and inforrnatioTr to farnilie5 and indMdua15 affecled by Rb. Raise funds to supwrt research into issues ￿cerned diwuy wth Rb. Raise awareness of Rb arnong health professionals and others. Influen￿ policy to improve service delivery for Ihose affected by Rb. Oble¢tlves, Strategles for A¢hlevement and Publ1¢ Benefft During the period of tris repDrt. we have conb.nued to SLKce5sfully delwer on our three core goals of support, research, and awareness. The Trustees have reviewed the Charitys cc*e goats and have reaffimed th* these remain the focus of all activity. The Trustees are aware of the public ￿nefft guidance wbl'shed by Ihe Charity Commission. W8 hav8 nsidered the obie¢tives ofthe Charity and have given regard to how these objects.ves and the assoc#ated activrtie5 tneet the public benefit criteria of advancing heatth. Saving lives and ihe relief of those in need by reason of ill heath. We are the onty dedicated UK-wde charity providing supwjrt to people affected by Rb and we believ8 that they benefit frorn our services in the folbwing ways-. Maln Oblectlves Support: To 8nsure that 8veryone affe(*8d by Rb in Ihe UK has ac(xss to support and information according to their need. Our Head of Supwjrt and two sUp￿rt Workers offer supwjrt to all families and individuals affected by Rb. This is provided cffi the wards and in clnics at ts¥o specialist witres for Rb in the UK.. Birrninghatn Women's and Children's Hospital and The Royal London Hospital. On non4inic days. support is provided via telephone. video Call. email. and social media. Support is a150 FKovided through the delNery of a pr(XJrarnrr￿ of quarterty face to face (x virtual meetings for famibes, teens and young adults. and aduks. CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 Additionally, our team provide swnposting to organisatKJns for financial grants, benefits advi(x, therapeutic and psychdogical suptx)rt, visual impaim)ent suprM)rL holidays, travel expenses, white goods. and other items. Our Support Workers aLso assist wtu) applicalw)ns for Blue Badges, Disabilty Lwing ￿k)wance an¢J Carer's Mlowance, as well as supporting lamilEs with hO￿[￿J ap￿Ications. The sUPPOrt tearn collaborates with Ihe wider CHECT teatn with stotie5 frotn rnernbers for CHECT publication5, information leafl8ts and social rnedia. Awareness - healthcare professionals= To save Iwes and rninimise th8 irnpact of visual itnpairtnent by Ènsuring that healthcare professionals know aboul Rb and its symptoms. listen lo ¢on¢emed parents and make urgent referrals where ￿e￿$Sary. We provide: Targeted aclivits.es to healthcare professionals a$￿ated wth chibj￿n aged six an(J under. Distribution of resources that help early diagnosis and referrdl. Media campaigns and articles for specia115t healthcare professional jouma15 and magazines. Working with heathGgre professionals to develop and implement standard referral protottjls for those wrth suspected Rb. Awarene$$ publ1¢= To inwse awa￿ne$S of Rb and its S￿n$ and symptoms amongsl parents and cAr8rs so as to prornot8 the seeking of rnedicAI advice as ￿M)n as possibl8. W8 do this by.. Ensuring inforrnation fvr parents aLwyJt the 5ymptorns of Rb 15 availab￿ in all re￿vant NHS publications and on all NHS infomiab"M websites. Media actwty regarijing Ihe con¢Jthon i1￿udIng the signs and symptorns and how I where to seek help. Devebping relationships with organisations able to reach large sections of the pu￿1¢ with a v￿W to raising aWa￿ne$S. Regular and sustained sooal media thty wih inf(mb"(m and adv￿ ac(tssible ￿ the tharity's webslte. Prornob'ng krK)wledge of th8 rx)ssible k)nger-tenn IM￿ of having had Rb as a Chi￿ with r8gard to genetics and other c2ncers. Infortnation ￿[npaign5 targeted towards affected by Rb as a child. ReSea￿h.. Proactively engaging in Ihe adVan￿m￿t of krthAe¢Jge of Rb. its treatrnent and its impact. We do this by". Supporting and fvnding dinical. psychosocial. and 5oentific research reL4ting to Rb. Working through the Seienbfic Advisory Comrntt188 to identfy and support suitabl8 proj8cts from wide range of sources_ Enwuraging applicat￿n$ from the lniema￿Onal ￿earch o)mmunity. Supporting multi-centre and intemational collaboratN)n indudiTrg the sharing of experience, kTh)wledge. and data. Influencing.. Working with other organisatw)ns to bting about improvements in the way in which servi￿9 are delivered both in the UK and intemationalty. We". Work with the treatment centres in the UK. the NHS Natti)nal Commissioning Group, National Artificial Eye Service: and other umbrella tmjdies who provide seNices lo people affected by Rb. Proaclive1y seek partnerships wth other charibes and organisaljons. Research Grant Maklng Polky We award grants to groups or indivkluals who wish to pursue researth projects or audits to advance the knowledge of Rb and related issues. Page 4 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 ApplicatM)ns go before the sC￿nt￿e Adwsory Commitlee ISACI which is made up of a CHECT Trustee plus experts from resear¢h and RtFrelaled fields. We also have thw K2y members representing families and the adult Rb cotnrnunity within the SAC. This Committee evaluates the validity and appropriateness of the [￿poSal$ using an ag￿ed scorlng rnatrix, seeking peer remew for large projects aThd where necessary for other reasons. before rnaking cornmendatk)ns to the Board for fvnding. Grant recipients are required to provkle six-monthly progress reports and present a final re￿rt to the Board on the ¢on¢lusion of the project befo￿ disseminating the findings and leaming through pre5entatK)ns and publI￿tIOns. Volunteers 30 voluni8ers (including Trusieesand SAC m8mb8rsl g8n8rousty gave thwr tim8 to support us throughoul the year. Whether it was one off or ongoing SUPPK)rt. we wouw like to thank each and every one of our volunteers for their invaluable contribution to our work. Page 5 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 ACHIEVEMENT AND PERFORMANCE Charltable a¢tlvitles Support Whilst one of our core priorities is Ihe delivery of support to the parents and t2rers of children affected by Rb, we have extended thi5 to encornpas5 anyone affecied, including teenagers whose unique need5 are V8ry different to those of a young child or baby, and adults, many of whoffl are living with thelate effects of the Irealmenl Ihey re￿1Ve￿ for Rb as a Child. Membership of CHECT Is open to anyone affeded by tinoblastoma las well as their friends and famityl. suptK)rtets of CHEGT and health professionaL%. and W8 do not charge a fe8. In 2022123. 100°A of families We￿ tsffe￿ support folh)wing a diagnosis of Rb In the UK. As well as face to face, email, and telephone, we continue to use virtual pL?tfo￿S to support our mernbers. There has been an increase in the nUM￿r of fa￿l￿(al￿ sessions del￿ered almost 1,3￿) sessions delivered across both treatment hospitals at inpab.enl and outpab.ent dinics. During th8 year, we conducted a detailed members. SUPFX)rtservices survey. Thi5 Vital exercis8 has gifted us with invaluable feedback to ensure that our service deveh)pments ar8 ccf)rodur*d with thos8 who continue to access our support io besl respond to ongoing needs. Fac8 to fac8 and remot8 SU The rnain areas that Peop￿ sought 5UPPWt from CHECT in 2022123 induded.. Pr8Ctic21 and emotional support. DI￿¢t finanoal supwrt and assistancewilh weffa￿ applications. Detailed inforrnation about Rb Ind￿Jing genetics. screening, fertility, and late effects of Rb. Signposbng to other speaalist organBats"(ms. Work and empk)yment suprth. Housing suptxxt". here was an inueased number of familes ￿ ￿￿1$ir0 and ￿￿elessness. incjudirtrg a rise in the numbers of those Coming fr(xr abroad to seek treatn￿ftt ts their chik1. This often requi￿ enhanced practical. financial. emobonal. and so¢¢1 supp(xL We also continue to recewe around 15% of our 8nquiri85 from rK)n-rnemb8r5. The58 rnaiTTrly wnsist of international patients requesting adV￿e as well as UK based parents who have symptom conwns in their child. Our"WOu￿ You Recogni%e Yc?" leafiet oMb"nues to be a vital resour￿ ts peop￿ to take ak*ry to these initial inve5tigatNe apwntsnents bwth CIn￿an5. Social rn8dia su ort Social Media is still an irDpK)rtant source of 5UPPOrt resouTces and inforrnation, wilh rnetnber5 contacting CHECT and our raising awareness on newer plattorms. like TikTok and Instagrarn. As well as our main public-facing Fae&tyJok page, we have twothsed groupsfor mernb8rs which arefor parents ofchildren with Rb and adults who have had Rb. both of which have seen an increase in membership in the period. Financial Su In 2022123 we provided 68 CHECT 5UPPOrt grdnts totaling £12,(KM) to families and individu81s to help with the costs associated wilh an Rb diagnosis and ongoing trealment- for example travel to and from hospital Page 6 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 as w811 as occasionally helping to buy Some speaalist equipm8nt ftx thos8 wlh a wsual impairfflent. The demand for suppcKt grants has drdmatic21ty in(xeased in line with the 1x)St￿f41v1ng (xsis and our team continue to w(xk in pathwship with otheror9ani8alKmS to as mud) finwal suprM)rt as possib￿. ort Events In 2022123, we organised 5 fac84￿faCe support events.. Family Days.. 3 events in Oxford. New¢asUe. and W￿xharn - Ihis induded the presentation of ovr CHECT Charnpions award to sorne incredi￿Y btave and desewving chikjren. Teenag8 and Young AduK D8y' 1 event in Birniingham. Adutt Day." 1 event in Liverp(x)l. Hospital organised events were also attended by wr support team. The 5UPPOrt 5erwce also delivergj online events". Family support.. 3 events. Teen and Young Adutt5". 2 events. Adutts.. 3 events. These virtual events provided opportunities for peer-to-peer supportand (x)nnected mernbers wth clinicians and speakers from other organisab.ons in¢luding the RNIB and Thomas Pitklington Trust. the Pen uin In February 2023 we produced ourfirst enUc￿ati0n supporttoy. Pip the Penguin, named by our membership, Is now being used as a suprx)rt t(x)I for families and dinoans to n(m)alise and eX￿81n the enudeation proTrss. Teena e and Youn Adu TYA ort A who had Rb as ¢hikI￿n can face Spe¢lf￿ chaI￿nge$ around seW*sleem. We a￿ increasingly looking at ways to support this grtyjp. to wowde speualist supwrt to meet need arKJ faalitate invaluable peer support. We have a specific group lor TYAs, and they created a n8w website which launthed in th8 autumn of 2022. The group rM)pulates the site with stories and infomation appropriate to their audience. This group also participated in a 'sooal tnedia take-over. of CHECT5 Flatfotms lo raise awareness in Teenage and Young Adutt Cancer Awareness month. Adults ond Rb For some people. the effects of Rb a￿ lrfeb)ng. We continue to ￿$[￿)nd to the needs of adutts wtho we affected by Rb as children. We have a specific Beyond Rb group. the membership of whith has grown Fa￿b￿k and the introduction of a WhatsApp Group. with high ￿velS of attendan￿ at online support events. The group have be8n h8avily involved in the pr(Kluction of our new suite of adu￿ pat*nl inf(xmation and resources. This includes a'my Rb Summary document. which is a critical resource as it allows individuals to document their Ire8tmenl surnmary and side effects. as well as gaining knowledge to minimise cancer risk and refflain vigilant for changes. particularly in th058 who have had faual radiotherapy or who have g8n8tic Rb. It will also be a guid8 f(x clinicians who r8Vi8W these patients in primary care settings and18te effects clinics. Partnershi Colkboration and pathetship development is a vital activty in the enhan￿rnent of our support prtsvision. Page 7 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 Ongoing partn8rship continues %wth immense grab'tude via Organisati￿5 such as Farnily Fund, Young Lives vs Cancer and the Gavin Gtynn FoLJndalion. Both SuprM)rt Workers cx)nlinue to offer activities to chIld￿n and young peop￿ Indi￿CtlY through partners such as Barretstobw. the Ellen MacArthurTrust. Over the Wall Camps and VICTA. New partnerships have enhanced supp(Yl for people affected by Rb and include Love Oliver who financialty and practicalty supportfarnilies travelling from Scouand for treatment,. and Free Kicks who gift our members experiences and free events tickels. Feedback "CHECT has been a tower of St￿n9th to us since wr 5-week-old baby was diagnosed with Rb. Right from the word 'go'. Whe￿ we We￿ lying in ple￿. a fa￿-tO-faCe support worker was in our room on the ward to rnake u5 aware how help could be prowded. We've gradually picked ourse￿e5 up but have continued lo rec8iV8 enormous help from CHECT in terms of people reguL3rty checking in with us at appointrnents to ntscting us when we are home. assisting with adapting to living with a chi￿ with ¢ancer. disability needs such as parking badges and CODrdinats"tvJ dttterent farnilies so that they can support one another. In a wor which ￿Ul￿ have been very isolab"ng. they made SU￿ this did not happen." (Father of a newly diagnosed babyl. °Thank you so much for your hdp, what woukl we do you." (Mum of a thild on active treatment) "I really app￿lated your help wth ￿ferring me to the Late Effects Clin￿. It has been a worrying ts.me but feeling tnuch better abouf everylhing now." (Adult ernaill °Thank you so much for en￿uragIftg me to ¢onta¢t my GP and optirian. l trKJk Ihe red rellex leaflet wth me.. {Worr￿d muml Awaren8SS Rb is a rare disease which Means Ihat most people are not aware of rt. Sadty, this frequenuy leads to a deL8y in a diagnosis being made and. because Rb is a fast-growin9 cancer. quick awess to treatment can be vital in order lo save a Chi￿.$ eyes. sHJht and Sfe. Raising awareness of Rb arnory both healthcare prof85sionaLs and the public is therefore important in h8lping to driv8 ear￿ diagnosis and as such remains a key part of our work. We are incre(libly grateful to the healthcare ptofessiona15 who volunteet their tirne on our Health Ca Professionals Focu5 Group, bringing their expertise and experience to enrich this aNwdrene5s programrne. Quite simpty, much of this work w(MJldnY b8 possible vAlhout their gen8rou5 inpul. Pathwa $toDia nosis In 2012. as part of rts aim to redu￿ the deLays in diagnosis of ￿tinoblaSt¢vna expQrnen￿d by some families in the UK, CHECT began to colknt infornation from parents &91￿.Pathw8yS io Diagnosis,. This infomiation is gathered by our Support Workers during the course of their ¢onversations with families and focuses on whether Ihe families had any prior awareness of retiTh)bbstoma." the signs they noticed In their child's eye5 that prornpted them to seek help". al￿ the a￿n5 taken by Ihe heallheare profes510nals they (x)nsulted. It became apparenl that the range of experien￿ was huge.. from families whowere referred to one of the two specialist Rb cent￿$ In the UK within days of noticing their child's symptoms.. to families who spent over six months and numerous visits lo various healtr¢are professionaL% befoTe anyone re¢ognise(l the signthcan¢e of what they were reporting or carried out the appropriate tests and rnade appropriate referrals. Recording these experiences in a quantilative way allowed CHECT to refine messages and information to add￿$$ those a￿8$ where il was most needed.. not onty to a￿rt parents of young children, but also GPS. Page 8 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 health visfLors and optick4ns to Ihe rnain signs syrnptorns of Rb, and the need for urgent exarnination and onward referral. In 2022 the total number of pathways coll￿￿ was 38. In 2022 we saw the besl referral rates re(x)rded sinc8 2012.. 73Yo of children with Rb receNing appropriate urgent referrals. and 3% wailing more than six months_ This is against the Èleven-yearaveragÈ of 480k urgent ferrals and 10% waiting more than six months. Urgent referrals by GPS in particular are showing an encouraging upward trend. wth 66% of GP5 whcb saw a ChI￿j wth Rb in 2022 Tnaking the appropnate urgent referral, vs the survey average of 42%. And ky)king back to 2012 when the survey started. just 28% of GPS made the appropriate uryent referral. White eye continues to be the most comrnon sign, with another record year for parents spotting the gkjw in 8 photo137% vs survey average of 18Yol. This is signthcant because white eye may be visibk via flash phottyjraphy earfier than it would be obseNable with the naked eye. contnbubng to eadier diagnoses. though Pathw8yS to Diagnosis is deS￿ne￿ to be a snapshot, or an indicator of trends in diagnosis in th8 UK, it is a key part of the resources we use to hetyj CHECT a¢h￿ve its aim of raising awareness of Rb in ord8r to aid eadier diagnosis. Public awareness Irs often parents or carers who spot th8 signs of Rb- wh81her thafs a white 8y8 S88n in a famity photo, a squint. or another sympiom- so publ￿ awareness is an imKKJrtant area of our work to help ensure a swift dk2gnosis. We use traditional and éigitsl media lo ￿a¢h parents and olher membets of the public and raise awarenes5 of Rb. Media.. P￿viouS ￿searCh carried out by. or on behaN of. CHECT has shown that many people first hear about Rb after wding an arti¢le. During the oporting peri(Kl we r￿1Ve￿ over 83 mentions In the media. in¢luding 29 national pieces. gwing an opportunty to seelhear of tnany Mill￿nSI1.8 billwl across all rnedi3 Outlets. Digital.. We continue to adapl the CHECT website to ensure Ihat it is easy to navigate and contains relevant and useful Informat*)n to visitors. The most vi%ited pages ￿maIn our white eye and signs an¢ symptoms aniy'what causes retinoblastOTna' pages. We have added an 'events' page to the websrte. so that we can publish the details of our upcoming support events. And, we have L3unched CHECT TYA - a new website aimed at teenagers and young adutts who have had retinoblasioma. The website includes b1￿$ writien by our members. infomiation and advice and helpful Snks. Social Media.. Social Media is a key tool to raise the awareness of Rb. In the rerifyj wr Instagram followers in¢reased by 23Yo, our Facebook followeTS by 2.1% and our Twtter f￿lOWerS by 4°kn. We ￿8¢he4 over 1 million people on Facebook, 174k people on In5tagram and over 135k Peop￿ on Twtter. We L3unched a TikTok channel, which ha5 over 180 follow8rs, and an In5tagrarn channel for CHECT TYA which has over 170 follow8rs. Ongoing ¢ommunicats"on". We send OLrt tnonthty newsletters and etnali 5 filkd upKJate5 relating to 5UPPOrt. awareness, research, fvndraising. stories. and events. In 2022123. the open rate5 averaged 43.2%. We pr￿u(￿ two editions of our magazine, InFocus, 8v8ry year- Ihis is distributed both digitally and in-print. WÈ offset Ihe c2thn foolprint for printing. We maintain a bk>J with content. including news. events. real life stories. research. arKI articles. Inclusivity We have created a Inclusivity Wothng Group to ensure that the tharity is fully acCessi￿e and represents all those we support. In the period outputs include". W8 are trdnsLgb'ng our signs and symptoms post8rs into the fve most ￿MmOn1Y spoken languag8S Page 9 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 in the United Kingdom. To date. Ihrough th8 generous support of PL4[￿t Languages, w8 hav8 trans18ted these into Polish and Romanian. We have looked al our a￿a￿ne$S malerial with the view of making it more inclusive and induded a child from a non-white ethnicity in our signs and symptoms imagery. We have now included the option of having our pronouns in oui ernail signatures. We now add image descripbons where appropri8t8 to ours(xial m8dkg posts, to make our rK)sts more accessible for those unable to ¥riew the pictures. We also use Case studies from a range of Rb expevences. induding those who a￿ blind. those who have h>st an eyelsl to Rb. and also those VA￿) have experienced differing levels of, or no visual irnpairment. a5 a resutt of their Rb. Research The period saw the ￿Mp￿tK)n of projects by Dr Jesse Bery I'cornparing bk)tMI to aqueous humor as a liquid bk)psy for retinoblastoma.. detemiining the superiority of the aqueous humour as a source of lumour DNA'I. Professor Majlinda Lako I'Assessing the feasibilty of pluripotent Stetn cell derived retinal organoid5 a5 a model system to testthe Safety and efficacy of chernotherapeuticagents in re￿nOblaSt0ma.I and ajoint-funded project with Fightfor Sight led by DrAmy Gerrish I'Furtherinvestigation into intra-ocular fluid as a liquid biopsy in retinoblastoma'l. Dr Jesse 8e The main finding from the research is that aqueous humour lorAH, taken frorn the eyel has a h￿her afflount and likelihood of findiro circulating DNA compared to the bh)cMI. and so would work better as a'liquid biopsy, lor relinobL2stoma. However. il has also found that imrK)rtant infomialion relating to an increased risk of metastati¢ disease may be found in the bkx￿. Although Ihi% Is rare in Ihe UK. it is the most dreade¢l oulwme In the care of children with Rb. Thus. this research provides addrtional eviden￿ that evaluating the blood 15 important and, in the futur8, may be used to guide any addrfional (thernoth8rapy treatfflents th8 child May need. Professor Ma'linda Lako Thi$ team su¢¢Èssfully devek)red lawrown ￿11 models Cal￿ wganoids. whi¢h can be used to test existing and new ¢hemolherapeuli¢ dTugs. In this way. the rrtheL% can be used lo find those treatments which are least likely to cause sight k)s5, whilst effectNety treating the retinoblastoma, as well as testing for optitnal doses priorto dinical trials. Dr Am Gerrish This project showed thal the 8n8ty5is of cell-free DNA within fluid tak8n from th8 eye b8 used as an attemative to tLJmour tissue, or'liquid bk)psy 11 for Ihe diagnosis of non-heritable retinobl85toma,' and 21 to identify those tumours that are more resistant to treatment. Not only c2n this infomiation be found from the one combined geneti¢ test limportanl. as there is limrted (tubr flu￿1 available for tesbngl. but the team has aL%o determined the optimal time point for ocular fluid ¢olle¢i¥)n to maximi5e ￿sU115. This wll be essential to facilitate implementation into diniGql Serv￿￿, which 15 rAanned Within the n8xt 24 months. CHECT Continues ¢0 support three Mgryng projerts.. Laborato l Basic science Professor Shin-lchi Ohnurna= Evaluation of PRELP fUnCtiC￿ using r8tinoblastoma saM￿es. p￿vIouS research by Professor Ohnuma has found that whiL8t PRELP protein is highly eXp￿Sse¢l in nomial tinal tissues, It is not expressed in ietinoblaslotna. Prelirninary data trom cell cultures indicate that administration of PRELP to the established laboratory reb'noblastoma (%ll lines inhibited cancer progression. Now, this team wants to confimi that these resuts havÈ dinir21 appliGqtion, by applying PRELP protein to the human retinoblastoma tissues and examiniro the effect on rebnoblasloma development. The advantage of Page 10 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 such an approach over some current melhods is that only affected cells will be impacted by the treatment, with no 8XP8ctsd t￿CIty to surrounding noffnal, unalfected retinal cells, thereby preserving more of the child's vision. Clinical Or Zerrin Onadirn.. Eloise Patterson Project.. Study of rerxyds held at The Royal London Hospital and chi￿h0O￿ Can￿r Resear¢h Group ￿ retinobL2Stoma pab.ents Phase 2. Thi5 project 15 Initially funded wa a donation frorn the Greenda￿ Foundation. inspired by a young adutt who has pr8viousty had retinobL45torna, Eloise Patterson. Phase I (collection of clinical and mutation data and linking to Public Health England records) is now complete. This will provide complete informatK)n on type of Rb, type of mutation, treatment. follow-up data on seu)nd primary iumours and causes of any deaths. We were delighted that tre Greendale Foundalion ptovided fiJrther support tts allow for an a(jdIt￿n>I phase to be delivered - Phase 11 Istatists'cal anatysis io ests'mate risks, whith it is hoped could potentialty lead lo Èarlier diagnosis and treatment of these Se￿nd cancers in current - and futurè - Rb populations), due to complete by the end of 2023. chosocial Dr Bob Phillips." Developing an evidence-ba*J psycho-edLKational intervention for teenagets and young adults who have had retinobla510rna. Ther8 is litt18 guidiry evid8nc8 about the specffic challeng8s that teenagers who h8V8 had r8tinoblastorna face as they transition towards adullh(x)d. Understsnéing the psyCho￿u¢8t10nal needs of teenagers and young aduts as they transrtion is essential rfwe are to offer effective intetvention5 to support thetn. This PhD studeniship aims to devekjp an ewdence-based intervention for teenagers and young adults with retinoblastoma that offers r?￿Vant, a(xeSSib￿. and effective psYcho￿u￿￿ti0n8l support. In 2022123 we continued our objethve of delwering an annual researth award. Professor Sei 'A retinal organoid plattorm for retinoblastoma d￿￿ devehjpmenl, will start in July 2023 and builds upon previous CHECT-funded ￿Search. Our thanks go to all members of our Suentific Advisory Group, both lay and professional, who volunteer their time to make CHECTS researth pr￿r￿MMe rM)Ssib￿. and thus support our aim of improving the lives of everyone affected by retinoblastoma in the fulure. Page 11 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 ACHIEVEMENT & PEFORMANCE Fundralslng Fundralslng Pollcy CHECT does not use fundraising services or extemal wofessw)nal fvn¢Jraisets to undertake its fundraising activities. Additionally, no data is shared with or 501d to any extemal agencies. The charty does not purchase external tssts of potential individual donors or undert8k8 direct mail appeals to such lists. The charity issues a biannual newsletter and a monthly e￿eWS1etter I bkjg Iboth of which can be easily unsubscribed Iroml that share information about the charitable work and fundraising actwitie5 undertak8n. The charty o¢¢asionalty invrtes inrjividuals to attend events bul does not exert uncluè pressu￿ to attend or to donate. 11 doe5 not approach or pre55ure vulnerable people lo support its work. A cotnplaints policy is in place and is acce55ible on the chartty's websr(e Iwww.chect.org.ukl. The charty adheres to the Fundraising Code ol Practice issu8d by the Fundraising Regulator. Any fundraising events ¢arried out on behaw of the ¢harity that we are aware of are supporte(l and monitored by the Fundraising Manager. Any tnaTkeling materia15 and approaches are checked that they compty with the Fundraising Code of Prèctice and details of income and expenditure are recorded by the Fundraising Manager. Incom8 is acknow18dg8d and grateful thanks are s8nl, typi&glly with a18tter and certificate. Comrnunity and Events We are incredibly grateful and a￿ayS oven¥helmed by the passion and dedi¢ation of our supporters. who go to such lengths to raise vttal funds for us through the events and sponsored challenges they organise. Highlights in¢lude'. In May. Clare Collins and a grwp of friends1s(xne of kn had never cyded t￿foreI tackled a ride trom Leeds io Inkersall, near Chesterfeld. They arrived an hourahead of schedule to a crowd of well- wishers sffting in the sunshine- and received a huge cheer, as well as raising £5,987. Natasha and Aex Finney held a Charity Night jointly for CHECT antj Bolton Wanderers In The Cornmunrty. With a magio3n. raffle and auction. eath charity re￿iVed a gift of £2.100. Joshua Young and six friends took on Ihe National 3 Peaks in 24 hour5 in June. They faced dtrficult conditions but batued through, completing the challenge in 22..28 hours, raising £2,113. Dean and Kellie Ascheri have been raising funds for CHECT for over 15 years. firstly by siaging football matches and then by hO￿ing their Annual Golf Day. whi¢h son Lu¢a now helps to organise. In 2022 they raised £2.235. bringing their total to over £30.000. Oliver Lea cycled from London to Paris over four days in September, to raise fund5 and awareness for CHECT. He achieved his aim and raised £2,930. Former Chair of the Board ol Trustees. Philip M(x)re. undertook Ihe New York Marathon in November. raising £4.611. For the 27th year Roisin Lynch. her lriend5 and latnity braved the cold waters of Donegal for their Annual Christtnas Day Swirn for CHEGf. raising £3.217. Since 1995. the Lynch farnily have raised a total of over £45,000 from this rnueh-antiupated event. Feslus Fearon and his njnning group. C(d Runnings. look on the challenge of the Liverp)ol Half Marathon In March and have raised over £5.150 fty CHECT. In October a total of 11 runner5 ran the post-covid restricted London Maiathon raising £39,000. Page 12 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 Charity of the Year Partnerships A huge thank you to the groups and organisations who chose us to be their Charity of the Year. We are very grateful to Next wa￿￿OU$lng and Twenty Essex for announ(ang that they ￿11 be suptx)itiry us in 2023. Corporate Support We a￿ very grateful for the ¢onlinued SUPKth we re¢eNe from longstaThJin9 suppfftrs Han)xk & Wood and AJF Corntnercial Busines5 Sales. Vision Ex ress CHECT has been a proud partner ofVIs￿ Express Sin￿ 2010. and the company has played an invaluable rcAe in helping us lo raise awa￿ne$S of Rb. as well as generating significant funds to support ourwork. Vision Express wa5 the first optician in Ihe UK to roll out a woiocol to ensure a quick and effective referral if Rb is suspected. Continuing our joint ¢harty partnership wilh Vision Exp￿$$ and the Ma¢ukr Society. Vision Express colleagues held Iwo rnonth5 of fundtaising in SeptemLEr and October. undertaking a creative variety of events and activitie5 to ra15e fund5 for the Iwo chariDe5. The charity partnership also saw the launch ofanother initiabv8-th8 Marvin the Mole soft toy. After appearing in Vision Express adverts. Marvin proved lo be su¢h a hit with the publi¢ that the high street opti¢ian brought him to lrfe as a fluffy mascot. going on sale bolh online and in sto￿$ In March 2022. 100% of all profits raised from the Sa￿ of Marvin go to help those affected by retinobkstoma and Peop￿ living ￿￿th matsjlar disease. Vision Express colleagues, and Marvin, o)ntribuied an amaing £124.468 to be shared belween the iwo charities dunng the penod. Birmin hatn O tical Now into the seventh yearofour partnership with Birmingham Optical. weare enormously gratefultoeveryon8 in the company for all their continued support through fundraising and awareness raising activities. hlin8 Contracts We are very grateful to all at Highline for ￿&￿Ing their second Annual Day, raising £3,250. ts Advisers Ltd We are extremely graleful to Atta Adwsers Ltd forchoosing to donale £5,IXJO to CHECT. We were nofflinated by a siaff m8mb8r, who has a clos8 friend who's relative Wds dk3gnosed with Rb. CField Constw¢tk)n We are very gr8tefLJI to CField ConstructK)n and all their staff members for challenging themselves to Collective￿ take 20.000.1)00 Sieps in February 2023. As a resuh. they raised a fantasti¢ £10.526 for CHECT. Sackers Partners LLP We are grateful to law fimi Sackers and Partners LLP. who generously make thwr fantastic m8eting spac8S availab￿ to us. As we have no meeting Spa￿ of our own. this has been an invaluable asset to us. Infllvldual Glvlng We are extrernely grateful to all those who suppwNt U5 ￿Lh a regulargrft th[￿gh a r￿nthlY pledge or Give A5 Page 13 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 You Eam, as well as to those who so generousty make a one-off donation to our charity. We understand that the economic S1kna￿On is dth￿Il for many and are very grdteful to all who donat8 to our charity. Trusts & Foundations 2022123 income from chariiabl8 trusts and foundations exceeded £222k and w8 are extremety grateful to 8V8ry trust and foundation that supported CHECTS work so generously in the period. In partieuLgr we express our gratiiude to the Clive Richards Foundalk?n who fulty funded a groundbreaking research project. and match funded the Christmas Appeal. We would a&0 like to thank the Greendale Foundation for many years of extremely generous supp)rt. Other funders induded the A¢obe Foundatk)n.' the Eveson Twst.. the February Foundation.. the Childwick Trust.. the Hobson Charity,. the David Family Fwndalion". the Lawson Trust." Ihe Jessica Malhers Trust and the Ulver5croft Foundatvjn. We a￿ enormously grateful lo every one of Ihe trusts arxj foundab.ons that have so kindly and generous supported CHEcfs work over the past year and send ourthanks to thetn all. In Memorlam Trustee5 and staff WoU￿j like to thank and offer sin￿re Cond0kn￿ to fatnilies and frierKJs who have given in mernory of a loved one during the year and are gratefvl to those who have kn'ndty remembered us in their Page 14 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 FINANCIAL REVIEW Resorves Policy CHECT maintain5 Its resefves under two cawones". (al unrestricleé Igenerall reseTves. which are available for general use in pursuance ofthe char?ty*objective5. and Iblrestricted reserves. whth areforspecificalty earmarked purposes such as medirAI research or support lo families belonging trj 8 particular 8rea. The unrestricted funds of the Chanty as of 31 March 2023 lotaled £444.946. The Trustees have deletrnined that the Charity should hdd at least six months of running expenses in ￿serve. This figure represents Ihe atnount required to Tun the charity for six months exduding winding up costs 8nd any special projects. Based on this ralculation. the required value of rÈsÈtvÈs for the year 2023-24 is £280.903. The resetves ￿k1 as on 31 Marth 2023 rep￿Sent 9. 4 monihs of budgeted expenditurewhith predicted atcuttent kve15 to Teduce to6.7 rrK)nths al trhe e[￿ of the coming financial year. Th8 Trusl8es r8V18w the Charitys r8S8rves rKJlry C￿ a reguL8r basis. The reser￿ position is r8POrted at every board meeting. Investment Policy Funds surplus lo itnTnediate requiTements are to be invested in interest bparing accounls without risk to the Gapital. Such accounts are to be those offered by Institutio￿ (x)vered by the Finanoal Se￿￿ Compensation Scheme IFSCSI. Fu￿8 r8quired for Immed￿18, Op8ral*￿81. requirements ar8 h81d ￿1h CAF Bank Ltd Page 15 CHILDHOOD EYE CANCER TRUST (REGISTERED NUM8ER.. 021439171 FINANCIAL PERFORMANCE The total incoming resources of Ihe Chanty were £646,954, wh￿h was an increase of £207,079 on 2021- 22,5 total income of £439,515. Total resollrr￿ expended during the year inueased accordingly io £604.PA1 12021-22". £481.7481. Overall, the Charity has recorde(l a surplus for the year of £41.753 compared to a deficit of £42.233 in 2021-22. As at 31 March 2023. this has resurted in net assets increasing from £403.193 at the preceding year end to £444.946. This is entirely cotnwi5ed of unrestricted fvnd5 12021-22.. unrestricted funds of £400,652 and restricted funds of t2,5411. Anticipalng that the chanty be opetating in a Challenging financial dimate It was planned to operate on a deficit budget in 2022123. Page 16 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 FUTURE PLANS Our vision continue5 to be th8 go-to charty in the United Kingdom for anyone affected by Rb. Our mission is to lessen the impact of ￿hnob￿St￿Ma by driving earfy ¢Jiagnosis. funding ￿Search. an offenng lifelong supwrt now for future generations. Our focus over the corning period is to C￿tInUe to d81iv8r on Ihe objects of the charity, and in particular to.. ANvays pla￿ those that we support at the centre of everythiThJ that we do. To In¢￿ase our impact by delwering In￿Mental impmvements in the delivery ol our Support. Research, Awareness. and Influence acbwty. To increase the levels of funds raised in an elhical and sustsinable manner. To live within our finanual means by being mindfvjl ol expenditure and protecting the pennies on the rx)und spent on charilable a¢bvty. To be digitally e￿ab￿d, focu5sed and savvy. To proactivety seek alliances and parlnerships to alk)w us to widen our re8ch, outputs, and impact. To b8 a Ggring and indusNe empbyer vthh a happy and lowssed learn. Support The delivery of lifelong leveL% of suprx)rt is Ihe key f<¢us of Ihe Charity with a f￿$ on ¢￿atIng a support pathway that identffie5 the key stage5 of the Rb joumey - research. pre diagnosis, diagnosis, treatment, follow up, end of Irf8. We will weave our infom)ath)n. pra¢ti¢al. soual. finanual. and emoti￿al support into the above and worf( towards wdening the offer or tx)Ih the dire(* and indirect {partn￿ShIp) delivere(l services. We have increased the frequency of both online and face to lace events. ensuring to offer an event in each of the UK'S regions annually and quarterly online events for TYA. farnily and Beyond Rb groups. Overall, we Can see an increase in Inte￿$1 and need Irom our members for these events. We continue to provide fir}an￿$ to eTrsU￿ the value ofour support gtants prowdes a Signif￿nt level of fin8ncial sUPP(xt to individual families. We will ¢ontsnue lo grow our collatMxalh)n wth third pattyes suth as the Ellen M¢Arthur Cancer Trust. Barret5town. Guide DLKJS. Over the Wall CaTnps and VICTA. alb￿ng more ehiKlren and young people to expernen￿ events that can increase Confiden￿ and resilience. We 8re aLso setting up more partnerships with other organisations and regionalty bas8d charities to off8r members grants, treats and short breaks. These indude fcx)tball bckÈts from Free Kicks Foundation and various holiday part(s. inclu¢Jing a CenterParcs fffeak. Research Research will Continue to be a vilal focus ts us and our members. We We￿ (Jelighw to be able lo make an award to Professor Gail Seigel for her pr(ye¢t -A ￿￿"Tha1 organoid platfomi for ￿￿"nobL2$torn8 drug developrnenf which cornmences in Juty 2023. We will continue to manage and support Ihe existing projects referenced earfier and continue our commitment to researth vw anotr*r call for projeds and a furlher investment during 2023-24 and beyond. Awareness The raising of awareness around the strjns and symptoms of Rb with the public and the medical prOfess￿n remains a vital function. Page 17 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 Using the "Pathways to Diagnosis" as the guNJe. we wll be fvEusing on key areas and mornents in the diagnostic pathway to ensure that the right peop18 have the light kno%￿edge and informatK)n at th8 right b"me. We a￿ investing more inthJAalmedia and a￿ cmts.ng engaging contenttoaid in the raising of aWa￿ne$S. Influence We wll continue to liaise with the drfferent otganisations invofved in a child and familys ioumey to rnake sure the Vol￿ of our tnetnbership is heard and helps Influen￿ all, to deliver the best and tnost effective 8xp8rience to all families. Through parlnership ané allian￿ working we ￿11 Iwk lo use our fKJSition to Fo$￿VelY influenc* policy to improve the pathways and a$Sc￿ated ol supwl for all those affected ty Rb. Page 18 CHILDHOOD EYE CANCER TRUST (REGISTERED NUMBER.. 021439171 STRUCTURE. GOVERNANCE AND MANAGEMENT Governln9 document The Childhood Eye Cancer Trust ICHECTI [￿e Chariv) is a charitable company lirnited by guarantee I'the Cornpany'l, incorporated on 141￿ July 1987 and a regisiered charity. The Company was established under Memorandum of Asso¢iatk)n. which established the objects and ry)wers of the Company and is govemed under its Articles of Assooation. The Iliredors of the Company are also charity trustees for the purposes of charity law and are known as the Board of Trustees llhe Board'l. The maximum number of trustees is 15. The Cornpani8s Articl85 were amended in 2008 with regards to the number of temis Trustees may $8rve. In October 2022. the Articles were further amended to rÈrTh)ve the requirement for Trustees to be re*lected periodi¢ally. This was be¢ause. nobng the size and natu￿ of the Charity it is diffi¢ull lo Identify suifi¢ient numbers ol appropnatety qualified and experienced ¢andKlates to fill such wsitions wilh the process also being adrninistratively cumbersome. ArnendmentS to the A￿￿e5 were a150 tnade to alli)w Society, General and Board of Trustee meetiws to be hekj remotety. Organisational structu The Board meets six times a year and at Ihe beginning of each meeting, the truste8s are requ8St8d to declare any conflicts of int8r8st. No conflicts of interest were declared during this finanaal y88r. Th8 Board's performan¢e and trustees, skilLs are reviewed periodically and where possible new trustees are recruited to meet any needs or gaps identified. The Charity is a signatory to the NCVO'S Good Governance Code for the voluntary and community sector. To assist in the effectiveness and smooth running of the Charity, the Board continues to resource two sub-¢ommittees to help oversee ¢ertain aspe¢ts of Ihe Charity's work. Sub-￿mMIttee$ are currently set up for." finance and risk and for reseaT¢h IS¢ienlifi¢ Advisory Committee). Th8 day-to-day rnanagement of the Charity is delegated lo the CEO, supported by the staff tearn. At the close of the year, staffing consisted of ten siaff.. a chief executive (four days a weekl,. 8 head of finance & operations Ifour days a weekl., an operalions manager Ifull timel.'two fundraising managers and one fundraising officer (full timel.. a hea¢ of suprM)rt (full timel and two support workers- one In London Ifour days a weekl and one in Birmingham (four days per weekl." an information & research rnanager (three days per w88kl,' and a commun￿tionS manag8r Ithr8e days p8r w88kl. The Childhoo(J Eye Cancer Trust is no- affiliated with any other charitable organisation and has no related parties ex¢ept as shown in the notes to the ac¢ounts_ The Charity is a member of the Association of Medical Research Charities. the National Institute of Heatth Research. and other charities with sitnilar aims to CHECT working within the of eye heatth, childhood cancer5, genetic disorders, and rare diseas8. Page 19 CHILDHOOD EYE CANCER TRUST IREGI$TEREO NUM8ER.. 021439171 Inductlon and tr21nlng of new trustees New tru5tee5 are provided wth 1nforrnati0￿ aboLrt their ro￿ and responsibiltties a5 r￿0￿r￿ended by the Charity Commission and the National Counul Voluntary OrganisatK)ns INCVOI. This indud8s.' the truste8 rde description 8nd person specificath)n relevant to the ro￿.. Ihe Charity's polices relevant to the Board Induding the confidenbality ￿l1¢Y.. and the eligibility wuirements for becoming a twstee. They are also supplied with 3 copy of the Mernorandurn and Artides of As500alion. the Strateg￿ devebpment plan and the chief executwe'5 report and minute5 from three previous board rneetings. Trustee roles are advertiS8d on th8 CHECT w8bsit8 and on o(rAsion, usiro 8xiernal recruitment Organisat￿n$. Enquiries are aLso cMY2sionalty re￿Ived from members. A selection panel made up of the CEO. the Chair and another trustee or a memberof the eharity Considers the application ancl the suitability of the applicant Using agreed crilena identsFied on the person 5pecffication and the role description. The prospective trustee is then invited lo obseNe a board tneeting prior to appointrnent and standing for election which 1$ voted on and approved by the board_ Indudion meetings ctsvering the backgtoun¢J to ¢)Jtrent mattets take pla￿ with the chief executive and key mernber5 of the staff team. Training on matters relevant to the role and responsibilities of trustees 15 encouraged and the Board subscribes to literature pertinent to good goveman(%. All trustees are required to sign.. a contract setting out their responsibilthes,. a rA)nfidentiality agreement., the conflict-of- i n te re st policy.. and Confirmation of their eligibility lo serve as a diredor. They are aL￿ asked to undergo Dis¢bsure and Bamng Service IDBSI ¢he¢ks. The majority of trustees have personal experien￿ of ￿tInO￿laSt0rna and Its impact but ind￿7￿U8L8 with other key skilL% are also recrurted to the Board lo ensu￿ an appropriate balance to rneet the needs of the Charity. Rlsk management The trustees regularfy as5e5S the ri5k5 to the Chanty and rnaintain a c(xnprehen5ive risk register which indudes plans to mitigate or manage the risks idenlified. Risks identffied as red on the risk register are wewed by Ihe Finan￿ and Risk Committee at each of their meetings and in detail th￿Ce a year. Their di5CUS5ions are reporte(l al each Board tneeling. who in turn undertake a detsiled review annually. The Chief Exe0j￿"Ve reviews on a ￿n￿thty basis after which any concems are discusseil with the Chair of the Fin8nce & Risk Committee. The twstees a￿ sab"sfied that there a￿ systems aThJ arraThJgnents in pla￿ lo manage the risks identifie¢ as far as possible. Page 20 Approved by order of the board of trustees on 27 November 2023 and signed on its behalf by: Ian Ellington - Trustee REPORT OF THE INDEPENDENT AUDITORS TO THE MEMBERS OF CHILDHOOD EYE CANCER TRUST Opinion We have audited the financial statements of Chibjhocwj Eye Cancer Trust (the 'tharitable company I for the year ended 31 March 2023 which comprise the Staternent of Finan(ial Acti￿tIeS, the Balance Sheet, the Cash Flow Statement. and notes to the finan(#al staiements. induding a summary of significant armunting policies. The financial reporbng framework that has been applied in their preparation is applicab￿ law and United Kingdom Accounting Standards (United Kingdom Generalty A￿ple¢ Awunting Practi￿1. Including Financial Reporting standaril 102 'The Financial Rep[￿lIng Standard applicaue in the UK ané Republic of I￿land.. In our opinion th8 financial stalem8nts'. give a true and fair view of the state ol Ihe charitab￿ company'$ affairs as at 31 Mar¢h 2023 and of its incoming resources and appkath)n of resourw. including ts in(x)me and expenditure. for the year then ended", have b88n property pr8par8d in accordan(x wth United Kingdom Generally Accepted Accounting Pr8ctice, induding Finanaal Reporting Standard 102'The Finanaal Reporting Stand8rd applicable in th8 UK and the Republic of Ireland.: and have been p￿pared in accordanee with Ule requirements of the C(xnpanies Act 2006. Basis for Opinion We conducted our audit in accordance with Intemalional SlandaTds on Auditing IUKI IISAS IUKII and 3pplicable law. Our responsibilities urider those 51andards are further descnbed in Ihe Auditor5 responsibilities for the audit of the financial statements section of our report. We are independent of the charitable company in accordance with the ethital requirements that are rdevanl to our audit of the finanaal statements in the UK, including the FRC'S Ethical Standard. and we have fulfilled our other ethical responsibililiÈs in accord8nce with these reouirements. We believethat the audr(evidence we have ci)tained is suffiueniand appropriak to provide a basis for our opinion. Conclusions Relating to Going Con￿rn In auditing the financial statements, we have Concluded that th8 tnJst88s' us8 of the going concern basis of accounting in the preparation of Ihe finanual statements is appropriate. Based on the work we have perfom)ed. we have not Klentified any material un¢ert8inties ￿lating to events or conditions that, individualty or cdlectively. may cast significant doubt on the charitable cotnpanys ability to continue as a going concem for a period of at ￿$1 Iwefve tnonths frotn when the financial staletnents arè authorised for issue. Our re5ponsibilitie5 and the reSpOn￿bIl￿e5 of Ihe trustees respect to going concem are described in the rel8vant seets'ons of this report. Other Infomiation The trustees are responsible for the other infomati￿. The other Infomiab.￿ comprises the infom)ation induded in the annual report, otherthan the finanaal statetneTrt5 and our Report of the Independent Auditors thereon. Our opinion on the finanoal staternenls does not cover the other informatK)n and. exTrpt to the extent otherwse 8xplicitty stated in our report, we do not express any form of assurance condusion thereon. In connection with our audit of the financial siatemenis, our responsibility is to read th8 other information and, in doing so. consider whether the Olher infomi8tM)n is materialty Inconsistent with the financial statements or our knowledge obtained In the audrt or otherwise appears to be tnaterially tlliS5tated. ff we Identify such rn31erial inconsistencies or appa￿nt material missiatements. we ao wuired to éetttmiine whether theo is a material mis5taternent in the finanoal statements ora tnaterial mis5taternentof the Oth￿ inforrnation. If. based on the work we h8ve performed, we conclude that there is a material rnisst8tement of this other inforniation, we 8re required to report that fact. We have nothing to re￿)rt in this regard. Page 22 REPORT OF THE INDEPENDENT AUD￿oRs TO THE MEMBERS OF CHILDHOOD EYE CANCER TRUST Opinions on Other Matters Prescribed by the Companies Act 2006 In our opinion, based on the work undertaken in Ihe course of the audf('. the infotrnation given in the ReFKKI of the Ttustees, which includes the Directors. Report prepared for the purposes of cornpany law. for the finanual year lor which the finanaal staternetts are prepared is (x)nsistent wth the financial statements., and the Report of the Trustees has been prepare(l in a0)ydan￿ with ap￿1%￿ble legal requirements. Matters on Which we are Required to Report by Exception In the light of the knowledge and understsnding of the ¢haritsbk company and its environment obtsined in the course of the audL we have WK)t ideTrtthed tnaterial mi5Statetnents in Ihe Report of ihe Trustees. We have nothing to rep￿ in resr*d Ofthefolk)v￿ng matters where the Companies Acl 2006 r8quires us to report to you if. in our Opin￿n.. adequate acGountiw re(x)rd5 have not been keptorretums adequateforouraudit have not been recewed from branches not wsf(ed by us.. or the financial statements are not in agreement ¥￿th the arLounting records and retum$.' or rtain disclosu￿$ of truslees ￿MuTh¢ra￿n spe(*fied by law a￿ not made.. or we have not ￿￿1Ve￿ all the infomiabon and explanations we requi￿ for our audit". or the trustees were not entrtled to take advantage of the small companie5 exemption frorn the requirernent to prepar8 a Strat8gic Report or in preparing the Rew)rt of th8 Trustees. Responsibilities of Trustees As explained MO￿ fully in the Statement of Trustees Resrx)nsibilities. the trustees Iwho are abo the directors of the charitable company for the purposes of cornpany lawl are responsible for the preparation of the finanaal statements and for being Satisfied that they give a true and fair view. for such Intemal control a5 the trustees detemiine is necessary to enab￿ the weparation of finanual staternentslhat are free frotn material tnisstatement, whether du8 to fraud or error. In preparing the finanual statetnents. the trustee5 are reskxjnsibk for assessing the charitable wrnpany s ability to continue as a going concem, disclosing, as applicable, matt8rs rekted to going concem and using the going concem b85is of accounting unless the trustees erther intend to liquidate the charitable company or to cease operations, or have no realistic attemative but to do so. Auditor's Responsibilities for the Audit of the Financial Statements Our obje¢ts"ves are to obtain ￿8$onab￿ ￿Uranc￿ about whether the financial statements as a ¥vhole a￿ free frotn material rn15Statement, whether due to fraud orerroy, and to issue a Report of the Independent Audrtors that includes our opinion. Reasonable assuran(￿ is a h￿h level of aSsurdr￿8, is not a guarante8 that an audit conducted in accordance with ISAS IUKI will always delecla material misstatement when it exists. Misstatements Can arise from fraud orerror and are consider¥J material if. individually or in the aggregate. they Could reasonably be expeded to infiuence the econom￿ de¢i%ions of usets tsken on the bags of these financial statements. Irregularttses, including fraud, are instances of non-cornpliance L4ws and reguL4tions. We design procedure5 in line with our responsibilrti8s, ouuined above, to delect material rnisstatements in respect of irregularities, including fraud. The extent to which our procedures are ￿9pab￿ of detecting irreguLgrities. including fraud is detailed below.. Page T3 REPORT OF THE INDEPENDENT AUD￿oRs TO THE MEMBERS OF CHILDHOOD EYE CANCER TRUST The chantable company is required to ￿mpty wth both company law ané Charity law as applicable in Engknd and Wale5 and. base¢J on our knowledge of rt5 activtties. we identffied that the legal requiretnent to accurately account for restricted fund5 was of key signfficance. We gained an understanding of how the Charitab￿ company complied with its legal and regulatory framework. including the requiremenl to properfy account for restricted funds. through discussions with marTragement and a ￿vIeW of the documented poli￿$. procedu￿$. and contrds. The audit team, which is experienced in the audrt of charities. considered the charitsble eotnpany 5 susceptibility to rnaterial misstatement and howfraud may (K(xJr. OurconsideratlOT15 induded the risk of management override. Our approach was to Check thal all wtricted in￿rne was properfy i¢entrfied and separately a¢counted for and to ￿SUre that onty val￿1 and appropriate expenditu￿ was ¢harge¢ to restricted funds. This Indude(I reviewing ioumal adjusttnents and unusual transactions. Afurther description of our respon5ibilrtie5 for the audit of the finanaal staternetts is located on the Financial Reporting Council s website at www.fvc.org.uklauditorsresponsibilities. This description fomis p8rt of our Report of the Independent Auditors_ Use of our Report Thi5 report is tnade solety to Ihe charttable company s rT*rnbers, a5 a l￿dy, in accordance wth Chapter 3 of Part 16 of the Companies Act 20(￿. Our audit work has been undertaken so that we rnight stale to th8 charitable company s members those matiers we are required to state lo them in an auditors, report and for no other purpose. To the fullest Èxient pem)itted by law. WÈ do not attept or assume responsibility lo anyone other than the chantable company and the charrtable cortwany's rnernbers as a body. lor our audit work. lor this report, orfor the opinions we have ft)rrned. Richard Billinghurst FCA (Senior Statutory Auditor) for and on bÈhalf of Knox CroppÈr LLP 65 Leadenhall Street London EC3A 2AD 0111212023 Date: ............................................. Page 24 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER: 021439171 STATEMENT OF FINANCIAL ACTIVITIES (INCORPORATING AN INCOME AND EXPENDITURE ACCOUNTI FOR THE YEAR ENDED 31 MARCH 2023 2022 Total fund5 Unrestricted fvnds Restricted fvnd$ 2023 Total fund5 Note5 INCOME AND ENDOWMENTS FROM.. 0on8tions and Legacies 553.401 639.710 436,899 Other Trading Activities 1.077 1,077 Investment In(x)rn8 5.807 5.807 1,775 Total £560.285 £86.309 £646.$94 £439.515 ExPEND￿vRE ON.. Raising Funds 169.066 169.066 135,198 Charitable adivities Medical Research and Grant Making 61.392 61.392 69,256 Awareness Raising 107,647 107,647 85,895 Famity Support and Infomiation 163.356 88.850 252.206 171,098 Influenang 14,530 14,530 20,301 Total £515.991 £88.850 £604.841 £481,748 NET INCOMEIIEXPENDITUREI 12.M11 41,753 142,2331 RECONCILATION OF FUNDS Total Fund$ Brought Forward 400.652 2.541 403.193 445.426 TOTAL FUNDS CARRIED FORWARD £444,946 £444,946 £403,193 CONTINUING OPERATIONS All Income and expenditure has arisen from continuing activiti.es. Page 25 CHILDHOOD EYE CAIKER TRUST (REGISTEReD MJMBVI: 9214391 n BALANCE SbEEf AT 31 PIARCH 2023 2022 XED ASSETS Tangbie Asseis CURRENT A￿ET3 rh*Ao 15 10,3B• 10.513 Cath al Bar& and ￿ H￿d 628,831 +>26.088 639,ZlY 636,601 CAEDifoRS Armurts Faliro Duewthin Y EfcuRREIIT ISSETS 1188,OlY) 451.202 1160.655 455.94S TOTAL ASSETS LESSCURRENr LIABILITES 451.687 466.883 REDITORS 17 181690 Y8ar 403.19> FUMOS Unrestrthd 400 652 R•Sts￿l&j fur 2.541 TOTAL FUNDS £4J3.193 fimiGo1 Stal￿erts p￿par￿a pi vthh the pth4ih)n8 v4pkab￿ b) thwitab ￿￿panIes£U￿IEtt. to the vnall r* Th?finaKrdl 8l*nRrtswwe Wty4*d tylhE Bo•d 0fT[u%t￿ sigr•l ￿ 18 bewby.. 27 November 2023 CHILDHOOD EYE CANCER TRUST (REGISTERED NUMBER: 021439171 CASH FLOW STATEMENT FOR THE YEAR ENDED 31 MARCH 2023 Notes 2023 2022 Cash flows from operaUng a¢￿vItieS. Cash Generated from 0per8b.ons (see below) {2.4871 158,4101 Finance Costs Pai¢J 22 15801 13911 Net Cash (Used inllProwded by Operaling Activities 13.0671 158,8011 Cash Flows from Investing AclivitiÈs- Interest Received 5.807 1.693 Net Cash Provided by Investing Acbvit¢s 5,807 1,693 Change in Cash and Cash Equivalents in reporting period 2.740 157,1081 Cash and cash equivalents at beginning of reportlng perlo f>26.088 683.196 Cash cash equlvalents at ot reportlny period £628.831 £626,088 Page 27 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER: 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 1. Accounting Policies Basis of preparing Ihe financial ststements The financial statements of the Charity. which is a publi¢ benefit entty under FRS 102. have been prepared in a¢wrdan¢e wth Ihe Charits"es SORP IFRS 1021'A¢counb"ng and RetK)rting by Charibes." Statement of Recommended Practice applicable to charitEs preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ir81and IFRS 1021,, Financial Rew)rting Standard 102 'The Financial Reporting Standard applicable in the UK and Republic of IreLgnd' and the Companies Act 2006. The financial stat8m8nts have been prepared under the histoncal cost Convention. Going concern The trustees consider that Ihe Charity's cash at the dale of apKmal of Ihe finan¢ial statements and its projected cash flows for the following year are sufficient such that the Charity retnains a going con￿rn for the foreseeable future, being a period of at least 12 rnonlhs trom the date of approval of these financial staternents. In rnaking this judgement, the trustees and senKK management team have Cor￿Idered luture agreed funding and th8 anticipat8d impact of extemal factors on futu￿ funding and expenditure. Critical accounting judgements and key sources of estimation uncertainty The preparation of financial statements in a￿)rdan￿ with generally a¢cepted a¢¢ounting practi￿ requires management to make esb"mates and judgements thal affect the reported amounts of assets and liabilities al the reporting date and the reported arnount5 of revenue5 an¢J expenses ¢Juring the re￿rtIng period. The critical judgements snd 8Stimat8s are reflected in these accounting polioe5. Income l incoming r8sourc8s ar8 included in th8 Statemenl of Finanrial Activities when Ihe Charity is entit18d to the in(x)me and the amount C8n be quanlif1ed wlh reasonab￿ a(ura¢y_ The folknving speryfic PDlicaes a￿ applied lo parti¢ular categories of in¢ome when appropriate.. Voluntary income 15 received byway of grants, donatK)ns and grfts and is included in full in the Staternent of Financial Activities when receivable. Grants. where entrtlernent is not conditionzl on the delivery of a specrfic performance by the Charity, are rec￿nISed when the Charity be(x)mes unconditionally entitled to th8 grant. Donated services and facilities are included at the value to Ihe Charity only where this can be quantified. The value of services provided by volunteer5 has nol been inchJded in these accounts. Donated good5 are rneasured al fair value and induded wtthin incorne. Investment In￿m8 is includ8d when rec8ivabl8. Expenditure Exp8nditure is recC￿niSed on an attrual basis as 8 liabilty is in￿rred. Expenditur8 includes any VAT that cannot be fully recovered. and is reported as part of the expenditure to wh￿h it relates.. Cost5 of generating funds comwi5e the costs asswateij wtth attracting voluntary incorne. Charitable expenditure comprises those costs incurred by the Chartty in the delivery of its actwitl8s and services for lis beneficiaries. It includes both (xjsts that Ggn be allorated dir8Ctly to such actNit18S and those costs of an indire¢t nature ne￿$sary lo support them. Governan￿ costs include those costs as5W31ed v￿h rneeling Ihe constitutional and statutory requirernents of the Charity and indude audit fees and costs linked to the strategic managetnent of the Chanty. All costs are allocated belween the expenditure categories of the Staternent of Finanual Activities on a basis designed to reflect the use of the resource. Costs relating to a particular activity are allocated directly, others are apporknoned on an appropriate basis e.g. tim8 ￿ estimated usag8 basis as set out in the notes to these a¢wunts. Page 28 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER: 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 1. Accounting Policies- continued Tangible fixed assets Tangible fixed assets are stated at cost less accumulated depreciation. The ￿st of Minor additions or th088 Costing below £2S) are not capitalised. Depreryab"on is provided at ra¢es cakulated to write off the Cost of each asset over Its expected useful lrfe. which in all cases is estimated at 4 years. Cash at bank and in hand Cash al bank and cash In hand indudes cash and short tem highty IK4uid inveslments with a short maturity of th￿e months or less from the date of acquisrtion or wniThJ of the deposit or similar account. Debtors Trade and olherdebtots a￿ re¢c¥Jnised atthe setUen*ntamount due. P￿paYments are valued at the amount prepaid net of any trade discounts due. Creditors Creditors are rec(MJnised al their 5etUement a￿u￿t, after allowing ft)r any ts3de d¢5(x)unts due. Financial instruments The Charity only has finarn￿al assets awKJ ffina￿al liabilthes of a kind that qualrfy as basic financial instruments. Basic finanual InStru￿￿nts are inthalty recognised at transactK)n valu8 and subs8qu8ndy MeaSu￿d al their settlement value. Employee beneffts Short-lerm benefits are ￿COgnised as an expense in the period in which the Servi￿ is re￿ived. Temiination beneffts a￿ accounted for on an a¢¢tual basis an¢J in line with FRS 102. The Charrty operates a defined contribution pension scherne. ContributlOn5 are tharged to the Staternent of Finanaal Activities in the period to which they rdate and are alloGgted belween activrfi'es and funds based on the use of the resource i. where employees spend their time_ Taxation The Chanty B exempt from (Or[M)rati￿ tsx on its charitsble a¢tivits"es. Fund accounting un￿strICted funds can be used in accordance with the charitabb obie¢tives al the dI￿retiOn of the trustees. Restri¢ted funds Can only be used for parti¢ubr ￿$tricted purposes wthin the objects of the Charity. ReStrI￿10n$ arise when specified by the don￿ or wyhen funds ao raised for particubr re5tn¢teLI purposes. FurtherexpL4nation of the nature and purw)5e ofeach fund is included in the notes tothefinancial staternents. Hlre pur¢hase and leasing commltments Rentals paid under operating ￿aSeS are charged on a strdight-line basis over the period of th818as8. Page 29 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER: 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 2. Donations and Legacies Unrestricted funds Restricted funds Total 2023 Total 2022 Grants Grants from Trusts & Foundations Governrnent Grant5 135.481 86.309 221.790 102.336 33,425 135,761 135.481 86,309 221,790 Donations.. General Donations Standing Orders In Memoriam 79.887 21.782 12.511 S.$49 1.149 79.887 21,782 12,511 S.$49 1,149 2.434 101,654 39.075 9,747 42.309 20,497 7,587 6.607 451 2.819 55,193 48.172 5,686 14.627 2,626 84,552 GAYE co1￿CtIng Tin5 Community Donations Other Corporate Donations London Marathon Gr8at North Run Digrtal Fundraising Campaign Other Running Events and walks Other events. Sporting Activrties and Community Fundraisers 101.654 39.075 9.747 66.251 72.881 66.251 72,881 412.920 412,920 291.126 Lega¢le$ 5.IXIO 5,1)00 10.012 Totsl Income from DonaVL)n$ and Legacie5 £S53.401 £86.309 £639.710 £436.899 The Trustees would like lo thank all Ihe members armj supporters wh) have o)ntributed their time and effort to raising rnoney forthe Trust. 3. Other Trading Activities 2023 Total 2022 Total Christmas Cards erchandise Sa￿$ 310 767 376 465 £1.077 £841 Page 30 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER.. 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 4. Investment Income 2023 Totsl 2022 Toial Divided In(x)m8 Bank Interest 82 1.693 £1,775 5,807 £5,807 5. Raising Funds 2023 Total 2022 Total Raising Donations and L8gaci8s Staff Costs Fundraising Costs Support Costs 99,822 8.171 61,073 79,638 9.474 46,086 £169,066 £135,198 6. Charitable Activities Grant Funding of Support Direct Costs Activities Costs Isee (see note 71 (see note 81 note 91 2023 Total Medical Research and Grant Makn'ng Awareness Raising Family Support and Informa￿'on Influencing 10,218 65,106 150,883 7,741 £233,948 7.674 42,541 87.988 6,789 £56.835 £144.992 61,392 107,647 252,206 14,530 £435,775 13.335 7. Direct Costs of Charitable Activities 2023 Total 2022 Total Staff Costs Newsletter Costs Awareness Campaign Other Direcl Costs Leanets and Printing 209.805 3.075 133.867 4,134 90 7,875 100 21,068 £233.948 £146.066 Page 31 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER.. 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 8. Grants Payable 2023 Totsl 2022 Tot81 Medical Research and Grant Making Farnily Supw)rt and Inforrnation 43,500 13,335 50,000 9.797 £56,835 £59.797 Page 32 ro (5)10 cr) C Tr- VO i*pllOIO O*YJ*r r* pioin 10 rin (4C*Vrr r*7b r*f*Uip ¢ty Op 0¢4 *rknT*r CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER: 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 10. Net Income (Expenditure) 2023 Total 2022 Total Auditors Remuneration Depreciation- Owned Assets Other Operating Leases Audiiors, Remuneration- Non Audit se￿ices 2,909 472 2.760 473 15,958 3,000 3,151 11. Trustees, Remuneration and Benefits There We￿ no twstees, ￿MuneratiOn or other benefrts for the year ended 31 Marth 2023 nor for the year ended 31 March 2022. Trustees Expenses During the year £129 of exper￿ were reimbursed io the TnJstees12022..NILI. 12. Staff Costs 2023 Total 2022 Total Wages and Salaries Social Security Costs Other Pension Costs Interim Fee5 Payab 369,537 26.338 7,401 32,491 £435,767 297,615 26.360 9,435 £333,410 Induded within wages and salaries are the direct costs of the interitn CEO. The average monthly number ofemployees during Ihe year was as follows.. 2023 Total 2022 Total Average Nurnber of Ernpkjyees 10 The number of employees whose empbyee b8neffts lexduding 8mpk)y8r p8nsion costs) exce8d8d £60,000 was.. 2023 Totsl 2022 Total £eO.O(M)- £70.000 Page 34 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER: 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 13. Comparatives For the Statement of Financial Activities Unrestricted Fund Restrlcted Funds rotal Funds INCOME AND ENDOWMENTS FROM Dollations and Legacies 381,438 55,461 436,899 Other Trading Aclivities Investment Income 1.T15 1,775 Total 384,054 55,461 439,515 EXPEND￿uRE ON Raising Funds 135.198 135.198 Charitable Activitie5 Medical Research and Grant Making Awareness Raising Family Support and Infomiation Influencing 69,256 85.895 117.836 20,301 69,256 85,895 171,098 20,301 53.262 Total 428,486 53,262 481,748 NET INCOME I[EXPEND￿uREl 144,4321 2,199 142,2331 RECONCILIATION OF FUNDS Total Funds Brought FoTward 445.084 342 445,426 TOTAL FUNDS CARRIED FORWARD 400.652 2.541 403,193 14. Tangible Fixed Assets computer and Offi¢e Equipment COST At 1 April 2022 and 31 March 2023 28.428 DEPRECIATION At 1 April 2022 Charge for Year At 31 March 2023 27.491 472 27,963 NET BOOK VALUE At 31 March 2023 At 31 March 2022 £465 937 Page 35 CHILDHOOD EYE CANCER TRUST {REGISTERED NUMBER.. 021439171 NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2023 15. Debtors.. Amounts Falling Due Within One Year 2023 Total 2022 Total Trade Debtors Other Debtors Prepaytnents and Accrued Income 123 2.792 7,473 526 2.792 7,195 £10,388 £10,513 16. Creditors: Amounts Falling Due Within One Year 2023 Total 2022 Total Trade Credrtors Pension Creditor Deferred Income Accruals 32,096 56.879 1,726 8,006 114,044 14,668 134,029 £183,018 £180,655 Included within Accwals is £79.936 for research grants awarded but expected to be drawn down wthin 12 months of the year end12022". £107.0481. D8ferred In￿rne relates to donations re(xwed in of firtur8 events, all of whth is released in th& following finanryal year. 17. Creditors.. Amounts Falling Due After One Year 2023 Total 2022 Total Accruals and Deferred Incom8 £6,721 £53,690 Accruals reflect grants awarded but not expecbj to be dra￿ down until r[￿re than 12 tnonths after th8 current year end. 18. Leasing Agreements Minimum lease payments Untyer Th)n