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2022-04-05-accounts

Trustees Professor Peter Cook
Professor Matthew Freeman
Professor Mark Greene
Professor Gillian Griffiths
Professor Henry Woudhuysen FSA
Charity number 309659
Auditor Critchleys Audit LLP
Beaver House
23-38 Hythe Bridge Street
Oxford
OX12EP
Bankers CAF Bank Ltd
West Malling
Kent
ME19 4JQ
Solicitors Mark Taylor
Knights
Midland House
West Way Botley
Oxford
OX2 OPH
Investment advisors Sarasin & Partners LLP
100 St Paul's Churchyard
London
EC4M 8BU
Schroder Investment Management Limited
1 London Wall Place
London
EC2Y 5AU
Baillie Gifford
Calton Square
1 GreensideRow
Edingburgh
EH1 3AN
Lansdowne Partners (LLP)
15 Davies Street
London
W1K3AG
UBS Wealth Management
5 Broadgate
EC2M 2AN

Page
Trustees report 1 - 3
StatementofTrustees responsibilities 4
Independent auditor's report 5-8
Statementoffinancial activities 9 - 10
Balance sheet 11
Statementofcash flows 12
Notes to the financial statements 13-22

25/11/2022

Current financialyear
Unrestricted Endowment Total Total
funds funds
2022 2022 2022 2021
Notes
£
£ £ £
Income and endowments from:
Investments 3 2,458,113 2,458,113 1,986,365
Other income 4 13,095 13,095 11,526
-
Total income 2,471,208 2,471,208 1,997,891
Expenditure on:
Raising funds 5 540,110 540,110 493,595
Charitable activities 6 4,480,883 4,480,883 10,090,831
Total expenditure 5,020,993 5,020,993 10,584,426
Net gains/(losses) on investments 11 - (8,921,711)
(8,921,711)
59,980,527
Net {outgoing)/incoming resources before transfers (2,549,785)
(8,921,711)
(11,471,496) 51,393,992
Gross transfers between funds (227,440)
227,440
Netmovementinfunds (2,777,225)
(8,694,271)
(11,471,496) 51,393,992
Fund balances at 6 April2021 (10,331,903) 185,662,152 175,330,249 123,936,257
Fund balancesat5 April 2022 (13,109,128) 176,967,881 163,858,753 175,330,249

Prior financialyear
Unrestricted Endowment Total
funds funds
2021 2021 2021
No~s £ £ £
Income and endowments from:
Investments 3 1,986,365 1,986,365
Other income 4 11,526 11,526
Total income 1,997,891 1,997,891
Expenditure on:
Raising funds 5 493,595 493,595
Charitable activities 6 10,090,831 - 10,090,831
Total expenditure 10,584,426 - 10,584,426
Net gains/(losses)oninvestments 11 - 59,980,527 59,980,527
Net (outgoing)/incoming resources before transfers (8,586,535) 59,980,527 51,393,992
Gross transfers between funds (1,745,368)
1,745,368
Net movementinfunds (10,331,903) 61,725,895 51,393,992
Fund balances at 6 April 2020 - 123,936,257 123,936,257
Fund balancesat5 April 2021 (10,331,903) 185,662,152 175,330,249

2022 2021
Notes £
£
£
£
Fixed assets
Investments 13 176,967,881 185,662,152
Current assets
Debtors 14 2,502
Cash at bank and in hand 1,144,536 1,935,141
1,144,536 1,937,643
Creditors: amounts falling due within one
year 15 (10,853,664) (7,889,546)
Net current liabilities (9,709,128) (5,951,903)
-
Total assets less current liabilities 167,258,753 179,710,249
Creditors: amounts falling due after more
than oneyear 16 (3,400,000) (4,380,000)
Net assets 163,858,753 175,330,249
Capital funds
General endowment funds 17 176,967,881 185,662,152
Income funds
Unrestricted funds (13,109,128) (10,331,903)
163,858,753 175,330,249

2022 2021
Notes £
£
£ £
Cash flows from operating activities
Cash absorbed by operations 20 (3,021,278) (3,515,300)
Investing activities
Purchaseofinvestments (33,631,125)
Proceedsondisposalofinvestments 33,403,685 2,089,920
Investment income received 2,458,113 1,986,365
Net cash generated from investing
activities 2,230,673 4,076,285
Net cash used in financing activities
Net (decrease)/increase in cash and cash
equivalents (790,605) 560,985
Cash and cash equivalents at beginningofyear 1,935,141 1,374,156
Cash and cash equivalents at endofyear 1,144,536 1,935,141

FOR THE YEAR ENDED 5 APRIL 2022 FOR THE YEAR ENDED 5 APRIL 2022
--
3 Investments
Unrestricted Unrestricted
funds funds
2022 2021
£ £
Dividends 2,456,865 1,962,583
Income tax reclaim 1,290 23,466
Interest (42) 316
2,458,113 1,986,365
--
4 Other income
Unrestricted Unrestricted
funds funds
2022 2021
£ £
Other income 13,095 11,526
--
5 Raising funds
Unrestricted Unrestricted
funds funds
2022 2021
£ £
Property maintenance and insurance 1,031 1,820
Investment management 539,079 491,775
540,110 493,595

Charitable activities
Total Total
2022 2021
£ £
Staff costs 34,227 22,968
Governance costs 20,605 18,172
Garden maintenance - Lincoln College 34,038
--
88,870 41,140
Grant fundingofactivities (see note7) 4,392,013 10,049,691
4,480,883 10,090,831
Grants payable
Grants Grants
Awarded Awarded
2022 2021
£ £
Grants 4,392,013 10,049,691
2022 2021
£ £
213 Contribution to nanobodies 50,000
269 Purchaseofequipment - Dunn School 133,505
278 OxVax: Establishment - Dunn School 28,216
279 Support Grant - Dunn School 134,433
280 Salary support - Dunn School 99,455
2812027 EPA Biomedical and Science Fellowship Endowment 6,800,000
282 Salary support - Dunn School 154,635
283 Salary support - Dunn School 142,807
284 Salary support - Dunn School 243,976
286 Coronavirus mitigation award 800,000
285 Salary support - Dunn School 1,200,000
287 Post-doctoral extension awards 132,274
288 Support grant - Dunn School 50,000
290 Molecular AnalysisofNon-apoptotic Caspase functions 139,472 180,385
291Genome stability and human disease 197,900
292 Salary support - Dunn School 165,630
293 Salary support - Dunn School 660,039
294 Oxford EPA studentships (2022-26) 469,733
295 Flow cytometry core facility 457,337
296 Salary support - Dunn School 93,665
297 Suiteofelectron microscopes 500,000
298 Salary support - Dunn School 91,151
299 Start up funding for three professorships - Dunn School 1,500,000
300 Start up funding for one professorship - Dunn School 200,000
301Start up funding for one professorship - Dunn School 150,000
302 Support for summer research placements 12,500

Grants payable (Continued)
4,687,427 10,099,686
Adjustments to the grants during the year were as follows:
2022 2021
£ £
213 SupportGrant- Dunn School (22)
(50,000)
250 Equipment upgrade - Dunn School 5
221Purchaseofconfocal microscope (50,000)
223 Dunn School Histology Department (512)
250 Upgrade AV provision (13,277)
260 Funding for Fournier (235)
261Postdoc extension awards (13,785)
264 Symposium Shanghai (8,754)
288 Support grant - Dunn School (28,444)
289 Salary support - Dunn School (180,385)
(295,414)
(49,995)
Governance costs
2022 2021
£ £
Other expenses 9,766 718
Trustees' insurance 1,031 833
Office insurance 482 482
Legal and professional fees 1,064 8,325
Bank charges 122 69
Auditors' Remuneration 8,048 6,374
Trustees' expenses 92 393
20,605 17,194
---

2022 2021
Number Number
Trust administrator
Employment costs 2022 2021
£ £
Wages and salaries 21,584 15,624
Social security costs 8,593 5,383
Other pension costs 4,050 1,961
34,227 22,968

Net gains/(losses)oninvestments
EndowmentEndowment
funds funds
general general
2022 2021
£ £
Revaluationofinvestments (8,921,711) 59,980,527
Tangible fixed assets
Freeholdproperty
£
Cost
At 6 April 2021 151,267
At 5 April 2022 151,267
Depreciation and impairment
At 6 April 2021 151,267
At 5 April 2022 151,267
Carrying amount
At 5 April 2022
At 5 April 2021

13 Fixed asset investments
Listed
investments
£
Cost or valuation
At 6 April 2021 185,662,152
Additions 33,631,125
Valuation changes (8,921,711)
Disposals (33,403,685)
At 5 April 2022 176,967,881
Carrying amount
At 05 April 2022 176,967,881
At 05 April 2021 185,662,152
14 Debtors
2022 2021
Amounts falling due within one year: £ £
Other debtors 2,502
15 Creditors: amounts falling due within one year
2022 2021
£ £
Grants payable 10,741,660 7,772,926
Other creditors 112,004 116,620
-
10,853,664 7,889,546
16 Creditors: amounts falling due after more than one year
2022 2021
£ £
Grants payable 3,400,000 4,380,000

Movementinfunds Movementinfunds Movementinfunds Movementinfunds
Balance at Incoming Resources Transfers Revaluations Balance at Incoming Resources Transfers Revaluations Balance at
6April2020 resources expended gains and 6April2021 resources expended gains and 5April 2022
losses losses
£ £ £ £ £ £ £ £ £ £ £
Expendable
endowment 123,936,257 1,745,368 59,980,527 185,662,152 227,440 (8,921,711) 176,967,881
123,936,257 1,745,368 59,980,527 185,662,152 - 227,440 (8,921,711) 176,967,881

Analysisofnet assets b etween funds
Unrestricted Endowment Total Un restricted Endowment Total
funds funds funds funds
2022 2022 2022 2021 2021 2021
£ £ £ £ £ £
Fund balances at 5
April 2022 are
represented by:
Investments - 176,967,881 176,967,881 - 185,662,152 185,662,152
Current assets/(liabilities) (9,709,128)
-
(9,709,128) (5,951,903)
-
(5,951,903)
Long term liabilities (3,400,000)
-
(3,400,000) (4,380,000)
-
(4,380,000)
(13,109,128) 176,967,881 163,858,753 (10,331,903) 185,662,152 175,330,249

Cash generated from operations 2022 2021
£ £
(Deficit)/surpus for theyear (11,471,496) 51,393,992
Adjustments for:
Investment income recognised in statementoffinancial activities (2,458,113) (1,986,365)
Fair value gains and losses on investments 8,921,711 (59,980,527)
Movements in working capital:
Decrease in debtors 2,502 136
Increase in creditors 1,984,118 7,057,464
Cash absorbed by operations (3,021,278) (3,515,300)