## 

## 

|Trustees and Officers||2-3|
|---|---|---|
|Chairman's<br>Statement||4-5|
|Trustees' Report||6-9|
|Statement ofTrustees' responsibilities|||
|Report ofthe Independent|Examiner ...|10|
|Grants awarded|||
|Statement ofFinancial Activities||12|
|Balance sheet||13|
|Cash Flow Statement||14|
|Notes to the Financial Statements||15-20|





## 

## 

|Professor Sir Charles George|Professor Sir Charles George|Chairman|(appointed<br>22.04.22)|(appointed<br>22.04.22)|||
|---|---|---|---|---|---|---|
|Roger Allsopp|||||||
|Professor Jonathan|Cole||||||
|Tony Cottam|||||||
|Professor Max Crispin|||||||
|Professor Diana Eccles||Dean ofthe Faculty ofMedicine,|||University|of Southampton)|
|Terry Madden||Chairman|(Retired 22.04.22)||||
|Luke March|||||||
|Nick Page|||||||
|Angela Suggate FCCA|||||||
|Michael Wilkins||Retired 14.10.22|||||
|Officers and Advisers|||||||
|Independent<br>Examiner|||PEH Wright|FCA DChaA|||
||||Sheen Stickland||||
||||Chartered<br>Accountants||||
||||Statutory Auditors||||
||||7East Pallant||||
||||Chichester||||
||||West Sussex||||
||||PO19 1TR||||
|Honorary<br>Solicitors|||Womble Bond Dickinson (UK)|||LLP|
||||Oceana House||||
||||Commercial|Road|||
||||Southampton||||
||||SO151GA||||





## 

|Professor Nick Evans|Chairman|Faculty of|Medicine, University|ofSouthampton.|
|---|---|---|---|---|
|Mr Brian Birch||Faculty of|Medicine, University|ofSouthampton|
|Dr Jeremy Blaydes||Faculty of|Medicine, University|ofSouthampton|
|Dr Katrin Deinhardt||Faculty of|Environmental<br>and Life Sciences||
|||University|ofSouthampton||
|Dr Jana Kreppner||Faculty of|Environmental<br>and Life Sciences||
|||University|ofSouthampton||
|Professor Deborah Mackay||Faculty of|Medicine, University|ofSouthampton|
|Professor Sumeet Mahajan||Faculty of|Physical Sciences and Engineering||
|||University|ofSouthampton||
|Professor Tiina Roose||Faculty of|Physical Sciences and Engineering,||
|||University|ofSouthampton||
|Professor Tilman Sanches-Elsner||Faculty of|Medicine, University|ofSouthampton|
|Professor Jon Strefford||Faculty of|Medicine, University|ofSouthampton|
|Dr Will Tapper||Faculty of|Medicine, University|ofSouthampton|
|Dr Dawn-Marie<br>Walker||Faculty of|Environmental<br>and Life Sciences,||
|||University|ofSouthampton||
|Dr Yihua Wang||Faculty of|Environmental<br>and Life Sciences,||
|||University|ofSouthampton||



## 



## 






## 


## 

## 

## 



## 

## 

## 

## 

## 



## 

## 

## 

## 



## 

## 

## 

## 




## 

## 




## 

||Grantee||||||||
|---|---|---|---|---|---|---|---|---|
||Research Project||||||||
|AC01|Dr Juliet Gray|||||||55,000|
||Faculty ofMedicine||||||||
||PhD Studentshi pjointly funded|with the Centre||forCancer|Immunology||||
||Student-Nubia<br>Castillo||||||||
||Enhancing<br>anti-GD2 chemwimmunotherapyin||||pre-clinical||neuroblastoma||
||models.||||||||
|AC02|Dr Yury Bogdanov|||||||55,000|
||Faculty of Medicine||||||||
||PhD Studentshi pjointly funded|with the Centre||forCancer|Immunology||||
||Student-Kaj aStoklaaa||||||||
||Deciphering<br>the role ofGABAergic signallingin|||||tumour vascularization|||
|AC03|Professor Karen Lillycrop|||||||31,386|
||Faculty ofthe Environment||and Life Sciences||||||
||PhD Studensthi pjointly funded|with Rosetrees||Trust|||||
||Student-4faisha<br>Chaudery||||||||
||Identifying<br>the causes ofmuscle stem|||cellaging||and novel|therapeutics||
||strategies||||||||
|AC04|3' Year Medical Student|Project Presentation|||Grants|||1,000|
|AC05|Dr Niall Hanrahan|||||||17,917|
||Faculty ofEngineering<br>and||Physical Sciences||||||
||Raman-on-a-chip<br>forlabel-free and culture-freeidentification||||||ofVBNCs||
|AC06|Dr Jade Forster|||||||19,943|
||Faculty ofMedicine||||||||
||Identifying<br>the underlying|molecular mechanisms||||and alterations ofthe high-|||
||risk neuroblastoma<br>tumour||microenvironmentin|||TH-MYCNmice treated with|||
||anti-GD2 antibody therapy.||||||||
|AC07|Dr Andrew Shapanis|||||||19,900|
||Faculty ofthe Environment||and Life Sciences||||||
||Development<br>and optimisation ofaserum based early cancer diagnostic||||||||
||system||||||||
||Annual<br>Total 2022|||||||200,146|
||Annual<br>Total2021|||||||110,919|





||||||||||||||||||||||||||~|~||||||~|~||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
||||~||.||~||||~|~|||||||||||||||||||||||||||
|~|~||.|~|||||||||||||||||||||||||||||||||||
|||||||||||||||||||||||||||||~||0|||||||||
||||||||||||||||||||I||I|II||||||||||||I|~|~|~|~|
||||||~||~||||||||||||||~|I|||||||||||||||||
||~||~|||||||||||||~|~|~|||||||||||||||||||||
|||||||||||||||||||||~|~||||||||||||||||||
||||||||||||||||||||~|||~|||||||||||||||||
|||~||~|||||||||||||||||||||||||||||||||||
|||||~|||||||||||||||||||||||||||||||||||
||||||||||~||||||||||||||||||||||||||||||
|||||||||||~|||~||||||I|||~|||||||~||I||||||~|~|
||||||||||||||||||||||||ill|ill|||||||||||||||
|||||||~||~|||||||||||||||||||||||||||||||
||||||0|~||~|||~||||~||||||||||||||||||||||||
|||||||||||||||||||||||||||~|~||||||||||||
||||||||||~||~|||~|||||||||||||||||||||||||





## 

|Balance Sheet asat 31|"December 2022||||
|---|---|---|---|---|
|||Note|2022|2021|
|||||F|
|Fixed Assets|||||
|Tangible Assets||10|||
|Investments||11|1,724,581|1,339,252|
||||1,724,581|1,339,252|
|Current Assets|||||
|Investments||12||31,503|
|Debtors||13|139,382|50,512|
|Short Term Deposits|||200,000||
|Cash at bank and in hand|||45,029|670,924|
||||384,411|752,939|
|Current<br>Liabilities|||||
|Amounts<br>falling due within|one year|14|(246,171)|(256,993)|
|Net Current Assets I(Liabilities)|||138,240|495,946|
|Total Assets less Current|Liabilities||1,862,821|1,835,198|
|Liabilities|||||
|Amounts<br>falling due alter more than one year||15|(213,262)|(171,019)|
|Net Assets||16|1,649,559|1,664,179|
|Funds|||||
|Unrestricted|General|18|1,571,342|541,698|
|Restricted||17|78,217|1,122,481|
|Total Funds|||1,649,559|1,664,179|





## 

|||||2022||2021|
|---|---|---|---|---|---|---|
|Cash from Operating<br>Activities|Note 1|||(45,612)||840,846|
|Cash Row from Investing|||||||
|Purchase<br>ofFixed Asset Investments<br>Sale ofFixed Asset Investments<br>Sale ofCurrent Asset Investments|||(800,000)<br>300,000<br>28,425||(500,000)<br>150,000||
|Distributions<br>Received|||91,292||50,903||
|||||(380,283)||(299,097)|
|Change<br>in cash and cash equivalents||in the period||(425,895)||541,749|
|Cash and cash equivalents<br>at 1stJanuary|||2022|670,924||129,175|
|Cash and cash equivalents<br>at 31st|December 2022|||245,029||670924,|



|Cash from operating<br>Activities|||||
|---|---|---|---|---|
|Net income/(expenditure)<br>I'or reporting||period per SOFA|(14,620)|1,124,486|
|Adjustments<br>Ior:|||||
|Distributions<br>receiMsd<br>Decrease/(increase)<br>in Debtors<br>Increase<br>in Creditors<br>(Decrease)/increase<br>in Grants<br>(Gain)/Loss<br>on Investments|payable||(91,292)<br>(88,870)<br>1,719<br>29,702<br>117,749|(50,903)<br>92<br>1,482<br>(114,957)<br>(119,354)|
||||(45,612)|840,846|





## 

## 

## 



## 

|||~|~|.|f|~|||
|---|---|---|---|---|---|---|---|---|
|||||~||~|~|~|
|~||~|||||||
||~|~|||||||



||0|||~|~|~|~||||
|---|---|---|---|---|---|---|---|---|---|---|
||~||~||||~|"|~|~|
|~|~|~||~|||||||



|~|~|~||||
|---|---|---|---|---|---|
||||~|~|~|
||||~|-|L|





## 

|6.<br>Allocatio|n ofSupport Costs||||
|---|---|---|---|---|
|||Raising|Charitable|Total|
|||Funds|Activities||
||||f|f|
|Oflice Costs||1,482|1,095|2,577|
|Professional|Fees|10,665|16,550|27,215|
|Audit Fees|||2,700|2,700|
|||12,147|20,345|32,492|



## 

## 

## 

||||||2022|2021|
|---|---|---|---|---|---|---|
|||||||f|
|Independent|Examiners|SeNIces|/|Auditors|2,700|3,900|
||||||2,700|3,900|





## 

## 

## 

|||||Fixtures, Fittings|Fixtures, Fittings|
|---|---|---|---|---|---|
|Costat1" January<br>2022||||and|Equipment<br>f<br>190|
|Additions||||||
|Disposals||||||
|Cost at31" December 2022|||||190|
|Accumulated<br>depreciation|at 1" January||2022||190|
|Charge Ibr year||||||
|Disposals||||||
|Accumulated<br>depreciation|at31" December 2022||||190|
|Net Book Value||||||
|31" December 2022||||||
|31" December 2021||||||
|11.Investments<br>at market value: fixed assets||||||
|Equities||||||
|Market Value at 1stJanuary<br>Additions||2022|||1,339,252|
|Disposals<br>Unrealised<br>Loss for the year|||||800,000<br>(300,000)|
|Realised Loss for the year<br>Market value at 31stDecember 2022|||||(94,755)<br>(19,916)<br>1,724,581|
|The historical cost ofinvestments<br>(2021:R1,151,123).||at 31"December 2022 amounted||to 81,727,935||



## 

|12.Investments<br>at market v|alue: current assets||
|---|---|---|
|Government<br>Stocks|||
|Market Value at 1stJanuary<br>Additions|2022|31,503|
|Disposals<br>Realised loss in year<br>Market value at 31stDecember 2022||(28,424)<br>(3,079)|





## 

## 

|13. Debtors||||
|---|---|---|---|
|||2022|2021|
|Other debtors||139,382|50,095|
|Prepay ments|||417|
|||139,382|50,512|
|14.Creditors: amounts|falling due within one year|||
|||2022|2021|
|||E|E|
|Grants payable||236,435|248,976|
|Trade creditors||2,801||
|Accruals||6,935|8,017|
|||246,171|256,993|



## 

|15.Cr|editors: amounts<br>falling due after|more than one year||
|---|---|---|---|
|||2022|2021|
|Grants|payable|213,262|171,019|
|||213,262|171,019|



## 

|||||||Unrestricted|Restricted|Total|
|---|---|---|---|---|---|---|---|---|
|||||||Funds|Funds|Funds|
||||||||R||
|Fixed|Assets|||||1,724,581||1,724,581|
|Current||Assets||||280,832|103,579|384,411|
|Current||Liabilities||||(233,670)|(12,501)|(246,171)|
|Amounts||tailing|due|alter|more||||
|than|1 year|||||(200,401)|(12,861)|(213,262)|
|Total|Net Assets|||||1,571,342|78,217|1,649,559|





## 

|~|I|I|~|I||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|||||||||~||~|||I|~|II|
||||||~|~|||||~ot|tli||||
||||||||~|.|I|||||||



|||||||||~|I|||||||~|I||~||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
||||||||||||||||||||||||||||~||~||
|||||||||||||||''|~||||||||||||||||
|||||||||||||||||||~||~|.|~|||||||||
||||||||||||||||||||||||||||~ I .|I|||
|||||||||||||I|~||||||||||||||||||
|||||||||||||||||||||||||||||~ I||~|
||||||||||||||||||||||||I|~|I|I ~I|||||
|~||~-|||||||||||||||||||||||||||||
|||-||||||||||||||||||||||||||~ ~|||
|~|||~|-|-|-|~|||I|~|||||||||||||||||I ~|||
||~|r.|||||||||||||||||||||||||||||
||||||||||||||||||||||||I||I|III|||||



|~|~|.|~|~||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|||||||||||||||~|~|||
||||||||||||||I||~|~|I|
||||||||||||I|~|I|I|I I|||
||||||I|I|.|~|=|I|||||||~'I|



