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|||**Page**||
|---|---|---|---|
|**Report o f the Trustees**|**1**|**to**|**7**|
|**Report o f the Independent Auditors**|**8**|**to**|**10**|
|**Statement o f Financial Activities**||**11**||
|**Balance Sheet**||**12**||
|**Cash Flow Statement**||**13**||
|**Notes to the Cash Flow Statement**||**14**||
|**Notes to the Financial Statements**|**15**|**to**|**24**|
|**Detailed Statement o f Financial Activities**|**25**|**to**|**26**|





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||||||**2021**|2020|
|---|---|---|---|---|---|---|
||||Unrestricted|Restricted|**Total**|Total|
||||fund|funds|**funds**|funds|
|||Notes|**£**|**£**|**£**|**£**|
||**INCOME AND ENDOWMENTS FROM**||||||
||Donations and legacies|2|**1,205,874**||**1,205,874**|700,161|
||Other trading activities|3|**18,310**||**18,310**|18,732|
||Investment incomc|4|**6,118**||**6,118**|**12,767**|
||**Total**||**1,230,302**||**1,230,302**|731,660|
||**EXPENDITURE ON**||||||
||Raising funds|5|53,896||53,896|55,558|
||**Charitable** activities|6|||||
||Grants||**371,242**||**371,242**|460,618|
||Governance related||**50,778**||50,778|53,016|
|.|Other support costs||||||
||||**38,175**||38,175|38,067|
||**Total**||**514,091**|**−**|**514,091**|607,259|
||Net gains on investments||**107,535**|**−**|**107,535**||
||**NET INCOME**||**823,746**|**−**|**823,746**|**124,401**|
||**Transfers between funds**|16|**1,351**|**(1,351)**|||
||**Net movement in funils**||**825,097**|**(1,351)**|**823,746**|124,401|
||**RECONCILIATION O F FUNDS**||||||
||**Total funds brought forward**||**3,194,482**|**34,568**|**3,229,050**|3,104,649|
||**TOTAL FUNDS CARRIED FORWARD**||**4,019,579**|**33,217**|**4,052,796**|3,229,050|





## 

## 

|||||**2021**|**2020**|
|---|---|---|---|---|---|
|||**Unrestricted**|**Restricted**|**Total**|**Total**|
|||**fund**|**funds**|**funds**|**funds**|
||**Notes**|**£**|**£**|**£**|**£**|
|**FIXED ASSETS**||||||
|**Tangible assets**|**11**|**13,936**|**33,117**|**47,053**|**49,913**|
|**Investments**|**12**|**1,607,535**||**1,607,535**|**−**|
|||**1,621,471**|**33,117**|**1,654,588**|**49,913**|
|**CURRENT ASSETS**||||||
|**Stocks**|**13**|**3,360**||**3,360**|**3,620**|
|**Debtors**|**14**|**45,774**||**45,774**|**27,082**|
|**Cash at bank and in hand**||**2,476,499**|**100**|**2,476,599**|**3,357,351**|
|||**2,525,633**|**100**|**2,525,733**|**3,388,053**|
|**CREDITORS**||||||
|**Amounts falling due within one year**|**15**|**(127,525)**||**(127,525)**|**(208,916)**|
|**NET CURRENT ASSETS**||**2,398,108**|**100**|**2,398,208**|**3,179,137**|
|**TOTAL ASSETS LESS CURRENT **|**LIABILITIES**|**4,019,579**|**33,217**|**4,052,796**|**3,229,050**|
|**NET ASSETS**||**4,019,579**|**33,217**|**4,052,796**|**3,229,050**|
|**FUNDS**|**16**|||||
|**Unrestricted funds**||||**4,019,579**|**3,194,482**|
|**Restricted funds**||||**33,217**|**34,568**|
|**TOTAL FUNDS**||||**4,052,796**|**3,229,050**|





## 

|||**2021**|2020|
|---|---|---|---|
||Notes|||
|**Cash flows from operating activities**||||
|Cash generated from operations|1|**614,931**|518,009|
|Net cash provided by operating activities||**614,931**|518,009|
|Cash **flows from investing activities**||||
|Purchase o f tangible fixed assets||**(407)**|(8,139)|
|Purchase o f fixed asset investments||**(1,500,000)**||
|Interest received||**4,724**|**12,767**|
|Net cash (used in)/provided by investing activities||**(1,495,683)**|4,628|
|**Change in cash and cash equivalents in the**||||
|**reporting period**||**(880,752)**|522,637|
|**Cash and cash equivalents at the beginning of**||||
|**the reporting period**||**3,357,351**|2,834,714|
|**Cash and cash equivalents at the end of the**||||
|**reporting period**||**2,476,599**|3,357,351|





## 

|**I.**|**RECONCILIATION O F NET INCOME T O NET CASH FLOW FROM OPERATING ACTIVITIES**|**RECONCILIATION O F NET INCOME T O NET CASH FLOW FROM OPERATING ACTIVITIES**|**RECONCILIATION O F NET INCOME T O NET CASH FLOW FROM OPERATING ACTIVITIES**||
|---|---|---|---|---|
||||**2021**|**2020**|
||**Net income for** **_the reporting period_ (as** **_per the_ Statement o f Financial**||||
||**Activities)**||**823,746**|**124,401**|
||**Adjustments for:**||||
||**Depreciation charges**||**3,268**|**2,200**|
||**Losses on investments**||**(107,535)**||
||**Interest received**||**(4,724)**|**(12,767)**|
||**Decrease in stocks**||**260**|**4,116**|
||**(Increase)/decrease in debtors**||**(18,692)**|**423,598**|
||**Decrease in creditors**||**(81,392)**|**(23,539)**|
||**Net cash provided by operations**||**614,931**|**518,009**|
|**2.**|**ANALYSIS OF CHANGES IN NET FUNDS**||||
|||**At 1.1.21**|**Cash flow**|**At 31.12.21**|
||**Net cash**||||
||**Cash at bank and in hand**|**3,357,351**|**(880,752)**|**2,476,599**|
|||**3,357,351**|**(880,752)**|**2,476,599**|
||**Total**|**3,357,351**|**(880,752)**|**2,476,599**|





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## 

|**2.**|**DONATIONS AND LEGACIES**|||
|---|---|---|---|
|||**2021**|2020|
||Donations|52,633|58,765|
||Gift aid|**5,409**|5,679|
||Legacies|**1,147,832**|517,943|
||Exceptional items||117,774|
|||**1,205,874**|**700,161**|
|**3.**|**OTHER TRADING ACTIVITIES**|||
|||**2021**|2020|
||Shop income|**18,310**|18,732|
|**4.**|**INVESTMENT INCOME**|||
|||**2021**|2020|
||Investment income|**1,394**||
||Deposit account interest|**4,724**|**12,767**|
|||**6,118**|12,767|
|**S.**|**RAISING FUNDS**|||
||**Raising donations and legacies**|||
|||**2021**|2020|
||Postage and stationer).|**1,401**|2,856|
||Subscriptions|1,398|362|
||Support costs|**41,026**|41,177|
|||43,825|44,395|





## 

## 

|**Other tra**|**ding activities**|||
|---|---|---|---|
|||**2021**|2020|
|Purchases||**10,071**|11,163|
|Aggregate|amounts|53,896|55,558|



## 

|**CHARITABLE ACTIVITIES**|||||
|---|---|---|---|---|
|||Grant|||
|||funding of|||
|||activities|Support||
||Direct|(see note|costs (see||
||Costs|7)|note 8)|Totals|
||f|f|f|f|
|Grants|1,375|369,867|−|**371,242**|
|Governance related|−||50,778|50,778|
|Other support costs|||||
||||38,175|38,175|
||1,375|369,867|88,953|460,195|



## 

|**GRANTS PAYABLE**|||
|---|---|---|
||**2021**|2020|
|Grants|369,867|460,618|
|**Reconciliation o f grants payable**|||
||**2021**|2020|
|Commitments at 1 January 2021 (note 15)|**188,374**|215,527|
|Commitments made in the year|369,867|460,618|
|Grants paid during the year|**(442,780)**|(487,771)|
|Commitments at 31 December 2021 (note 15)|**115,461**|188,374|





## 

|**Name and address o f recipient**|**Purpose** **_o f_ grant**|Amount|
|---|---|---|
|**institutions**|||
|**Prof I**M Wonnstone,School of|Funding the I lumane Research Trust laboratory; tissue culture|159,016|
|I3iological Sciences,University o f East|human lens epithelial cells.||
|Anglia|||
|Dr M Williams,School o f Biological|Development o f a xeno−free living human intestinal tissue bank|25,016|
|Sciences,University o f East Anglia|and next generation 3D culture systems for the investigation o f gut||
||health and disease.||
||Designer human intestinal organoids for the study o f colon cancer|(841)|
||prevention.||
||I luman mini intestines to study gut health and disease.|49,624|
|Prof kV**D** Fraser,Norwich Medical|Single cell RNA sequencing in childhood bone cancer circulating|24,306|
|School,University o f East Anglia|tumour cells.||
|Dr Gavrilovic,Norwich Medical|Reasons for poor wound healing in diabetic patients.|8,978|
|School,University o f East Anglia|||
|Prof L Paraoan,Department o f Eye and|At the crossroads o f apoptosis and inflammatory pathways. How|23,620|
|Vision Science,University o f I.iverpool|does PERP function as a key junction.||
|Dr N llodges,School o f|Understanding the role o f cytoglobin in cancer cell resistance to|36,299|
|I3iosciences,University o f Birmingham|cisplatin.||
|Prof M Coleman,School o f Life and|Development o f a human in vitro model for the role o f the|38,576|
|Health.Scienees,Aston University|immune system in Huntington's disease using human induced||
||pluripotent stem cells.||
|Dr R Thompson,Department o f Oncology|Developing new ways to battle cancer drug resistance.|5,273|
|and Metabolism, Sheffield University|||
|||369,867|
|**Contingent liabilities settled during the**|year|**442,780**|





## 

|**SUPPORT COSTS**|||||
|---|---|---|---|---|
|||Support||General|
|||costs|Consulting|postage|
|||£|£|£|
|Raising donations and legacies||**13,617**|**423**|**2,038**|
|Governance related||**13,222**|**6,328**|**1,222**|
|Other support costs|||||
|||**13,222**|**1,687**|815|
|||**40,061**|**8,438**|**4,075**|
|||Advertising|||
|||and|Governance||
||Staff Costs|publicity|costs|Totals|
||f|£|f|£|
|Raising donations and legacies|**22,504**|**2,444**|**−**|**41,026**|
|Governance related|**21,840**|**−**|**8,166**|**50,778**|
|Other Support costs|||||
||**21,840**|**611**||**38,175**|
||**66,184**|**3,055**|**8,166**|**129,979**|
|Activity|Basis of allocation||||
|Support costs|Staff tiine/Specific||||
|Consulting|Staff time/Specific||||
|General postage|Staff time/Specific||||
|Staff Costs|Staff time||||
|Advertising and publicity|Specific||||
|Depreciation|Staff time/Specific||||
|Governance costs|Specific||||



## 

## 

## 

|**STAFF COSTS**|||
|---|---|---|
||**2021**|2020|
|Wages and salaries|**62,286**|75,470|
|Social security costs|**1,967**|2,311|
|Other pension costs|**1,931**|2,195|
||**66,184**|79,976|
|The average monthly number o f employees during the year was as follows:|||
||**2021**|2020|
|Administration|2|3|





## 

## 

||Freehold||Office||
|---|---|---|---|---|
||property||_equipment_|Totals|
|||||f|
|**COST**||||.|
|At 1 January**2021**|**67,546**||**17,774**|**85,320**|
|Additions|||**407**|**407**|
|At 31 December 2021|67,546||**18,181**|**85,727**|
|||.|||
|**DEPRECIATION**|||||
|**At 1 January** 2021|**26,828**||**8,579**|**35,407**|
|Charge for year|**1,351**||**1,916**|**3,267**|
|At 31 December 2021|**28,179**||**10,495**|**38,674**|
|**NET BOOK VALUE**|||||
|At 31 December 2021|**39,367**||**7,686**|**47,053**|
|At 31 December 2020|40,718||9,195|49,913|



## 

|**FIXED ASSET INVESTMENTS**||
|---|---|
||Listed|
||investments|
|**MARKET VALUE**||
|**Additions**|**1,500,000**|
|**Revaluations**|**107,535**|
|At 31 December 2021|**1,607,535**|
|**NET BOOK VALUE**||
|At 31 December 2021|1,607,535|
|At 31 December 2020||



|Cost or va|lua|tion at 31 December 2021 is represented by:||
|---|---|---|---|
||||Listed|
||||investments|
|Valuation|in|2021|**107,535**|
|Cost|||**1,500,000**|
||||**1,607,535**|





## 

|||**2021**|2020|
|---|---|---|---|
|Cost||**1,500,000**||
|Aggregate|provisions|**(107,542)**||



## 

|||||**2021**|2020|
|---|---|---|---|---|---|
||Stocks|||**3,360**|3,620|
|**14.**|**DEBTORS: AMOUNTS FALLING DUE WITHIN ONE YEAR**|||||
|||||**2021**|2020|
||Trade debtors||||2,520|
||Prepayments and accrued income|||_<br>42,983|21,962|
||Prepayments|||**2,791**|2,600|
|||||**45,774**|27,082|
|**15.**|**CREDITORS: AMOUNTS FALLING DUE WITHIN ONE YEAR**|||||
|||||**2021**|2020|
||Trade creditors|||**1,953**|9,360|
||Social security and other taxes|||1,459|2,290|
||VAT|||2,236|770|
||Grants payable|||**115,461**|188,374|
||Pensions payable|||116|252|
||Accruals and deferred income|||6,300|7,870|
|||||**127,525**|208,916|
|**16.**|**MOVEMENT** **_IN_ FUNDS**|||||
||||Net|Transfers||
||||movement|between|At|
|||At 1.1.21|in funds|funds|31.12.21|
|||f|f|f|f|
||**Unrestricted funds**|||||
||General fund|**3,194,482**|**823,746**|**1,351**|**4,019,579**|
||**Restricted funds**|||||
||**Property** Reserve|**34,468**||**(1,351)**|**33,117**|
||**Trust Fund**|**100**|||**100**|
|||**34,568**||**(1,351)**|**33,217**|
||**TOTAL FUNDS**|**3,229,050**|**823,746**||**4,652,796**|





## 

||Incoming|Resources||Gains and|Movement|
|---|---|---|---|---|---|
||resources|expended||losses|in funds|
||f|£||f|f|
|**Unrestricted funds**||||||
|General fund|**1,230,302**|**(514,091)**||**107,535**|**823,746**|
|**TOTAL FUNDS**|**1,230,302**|**(514,091)**||**107,535**|**823,746**|
|**Comparatives for movement in funds**||||||
|||Net||Transfers||
|||movement|•|between|At|
||At 1.1.20|in funds||funds|31.12.20|
||£|**f**||**f**|**f**|
|**Unrestricted funds**||||||
|General fund|3,071,481|124,401||(1,400)|3,194,482|
|**Restricted funds**||||||
|Property Reserve|33,068|−||1,400|34,468|
|Trust Fund|100||||100|
||33,168|||1,400|34,568|
|**TOTAL FUNDS**|3,104,649|124,401|||3,229,050|
|Comparative net movement in funds, included in the above arc as follows:||||||
|||Incoming|Resources||Movement|
|||resources||expended|in funds|
|||£||**f**|**f**|
|**Unrestricted funds**||||||
|General fund||731,660||(607,259)|124,401|
|**TOTAL FUNDS**||731,660||(607,259)|124,401|





## 

## 

|||Net|Transfers||
|---|---|---|---|---|
|||movement|between|At|
||At 1.1.20|in funds|funds|31.12.21|
||**f**|**f**|**f**|**f**|
|•**Unrestricted funds**|||||
|General fund|3,071,481|948,147|(49)|4,019,579|
|Restricted funds|||||
|Property Reserve|33,068||49|33,117|
|Trust Fund|100|||100|
||33,168||49|33,217|
|**TOTAL FUNDS**|3,104,649|948,147||4,052,796|



||Incoming|Resources|Gains and|Movement|
|---|---|---|---|---|
||resources|expended|losses|in funds|
||£|f|f|£|
|**Unrestricted funds**|||||
|**General fund**|1,961,962|(1,121,350)|107,535|948,147|
|**TOTAL FUNDS**|1,961,962|(1,121,350)|107,535|948,147|



## 

## 

|Brought forward at 1 January 2021|**598,399**|
|---|---|
|New commitments awarded in the year|**899,818**|
|Grants paid in the year (note 7)|(369,867)|
|Commitments revoked in the year|**(19,710)**|
|Carried forward at 31 December 2021|**1,108,640**|





## 



## 

||**2021**|**2020**|
|---|---|---|
|**INCOME AND ENDOWMENTS**|||
|**Donations and legacies**|||
|**Donations**|**52,633**|**58,765**|
|**Gin aid**|**5,409**|**5,679**|
|**Legacies**|**1,147,832**|**517,943**|
|**Exceptional items**||**117,774**|
||**1,205,874**|**700,161**|
|**Other trading activities**|||
|Shop income|**18,310**|**18,732**|
|**Investment income**|||
|**Investment** income|**1,394**||
|Deposit account interest|**4,724**|**12,767**|
||**6,118**|**12,767**|
|**Total incoming resources**|**1,230,302**|731,660|
|**EXPENDITURE**|||
|**Raising donations and legacies**|||
|Postage and stationer),|**1,401**|2,856|
|Subscriptions|**1,398**|362|
||2,799|3,218|
|**Other trading activities**|||
|Purchases|**10,071**|11,163|
|**Charitable activities**|||
|Legal fees|1,375||
|Grants to institutions|369,867|460,618|
||**371,242**|460,618|
|**Support costs**|||
|**Support costs**|||
|Rates and water|2,521|3,000|
|Insurance|3,334|2,776|
|Light and heat|**1,717**|798|
|Telephone|3,099|2,819|
|Postage and stationery|5,474|1,401|
|Sundries|3,406|.4,114|
|Consulting||100|
|IT software and consumables|**2,817**|2,139|
|Subscriptions|113||
|Carried forward|**22,481**|**17,147**|





## 

|||**2021**|**2020**|
|---|---|---|---|
||Support costs|||
||Brought forward|**22,481**|**17,147**|
||Repairs and maintenance|**9,043**|1,591|
||Travel expenses|396|24|
||Cleaning|**486**|**434**|
||Bank Charges|**4,387**|**2,274**|
||Freehold property|**1,351**|**1,400**|
|•|Office equipment|**1,917**|**800**|
|||**40,061**|23,670|
||Consulting|||
||Consulting|8,438|11,306|
||General postage.|||
||Postage and stationery|2,721|3,500|
||Postage operating lease|**1,354**||
|||**4,075**|3,500|
||**Staff Costs**|||
||Wages|62,286|75,470|
||Social security|**1,967**|2,311|
||Pensions|**1,931**|**2,195**|
|||**66,184**|79,976|
||**Advertising and publicity**|||
||Advertising|**3,055**|4,523|
||Governance costs|||
||Auditors' remuneration|7,965|6,250|
||Auditors' remuneration for non audit work||2,635|
||Travel|7|400|
||Trustee meetings|**194**||
|||**8,166**|9,285|
||Total resources expended|**514,091**|607,259|
||Net income|**716,211**|**124,401**|