2025-09-30-accounts - Act For Cancer

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REGISTERED CHARITY NUMBER: 1210147

REPORT OF THE TRUSTEES AND

UNAUDITED FINANCIAL STATEMENTS

FOR THE PERIOD 20 SEPTEMBER 2024 TO 30 SEPTEMBER 2025

FOR

ACT FOR CANCER

Marsh Solutions Limited 82 Berechurch Hall Road Colchester Essex CO2 8RF

ACT FOR CANCER

CONTENTS OF THE FINANCIAL STATEMENTS for the period 20 September 2024 to 30 September 2025

	Page
Report of the Trustees	1 to 6
Independent Examiner's Report	7
Statement of Financial Activities	8
Balance Sheet	9
Notes to the Financial Statements	10 to 12
Detailed Statement of Financial Activities	13

ACT FOR CANCER

REPORT OF THE TRUSTEES for the period 20 September 2024 to 30 September 2025

The trustees present their report with the financial statements of the charity for the period 20 September 2024 to 30 September 2025. The trustees have adopted the provisions of Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).

MISSION< VISION & VALUES

The Mission of ACT for Cancer is:

To empower cancer patients, caregivers and clinicians by providing clear, reliable and unbiased information on cancer treatment options that currently exist outside of standard care, and to help individuals navigate complex treatment landscapes, including clinical trials and personalised medicines, with transparency, scientific integrity and patient-centred guidance.

The Vision of ACT for Cancer is:

A world in which every person facing a hard-to-treat cancer diagnosis has access to the information, knowledge and support they need to explore every available option, regardless of their background or the limitations of standard care.

The Values of ACT for Cancer are:

Patient-centred guidance
Scientific integrity
Transparency
Accessibility
Collaboration

OBJECTIVES AND ACTIVITIES

Objectives and aims The charity's two charitable objects, as set out in its governing document, are:

1 Relief of Sickness: to preserve and protect the health of patients with advanced or hard-to-treat cancer who may be seeking clinical trials and expanded treatment options, by providing and assisting in the provision of support and advisory services not normally provided by the statutory authorities.
2 Advancement of Education: to advance the education of the public in health care through the provision of expert information sites, symposiums and publications devoted to treating advanced cancer.

ACT for Cancer operates primarily through its ACT Info Hub: A free, publicly accessible online resource offering evidence-based information on cancer treatments and clinical trials outside of standard NHS care. This includes content on immunotherapies, off-label and repurposed treatments, and clinical trial navigation for patients, caregivers and clinicians.

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ACT FOR CANCER

REPORT OF THE TRUSTEES for the period 20 September 2024 to 30 September 2025

OBJECTIVES AND ACTIVITIES

Significant activities

The charity was incorporated on 20 September 2024. The first formal trustee board meeting took place in February 2025, marking the charity's operational launch. Significant activities during the period therefore relate primarily to the period from February 2025 onwards.

During this period, the charity's principal activities were:

Formal establishment of the trustee board and adoption of governance documentation, including Terms of
Reference. One new trustee joined the board in February.
Development and continued publication of the ACT Info Hub, providing free access to evidence-based
information on cancer trials and treatments outside standard care.
Authorship and publication of one academic poster presented at the Festival of Genomics and Biodata, London;
one White Paper and further research to supplement rolling out the next phase of ACT for Cancer's study
'Navigating cancer treatment beyond standard of care: Understanding patient access'.
Training undertaken and completed by ACT's Medical Content Editor in CPD accredited and certified course:
'Introduction to Medical Writing and AI' (Health Writer Hub)
Implementation of AI-assisted content generation tools, alongside measurable protocols for credible and
structured content (via the Elicit medical publications platform), which has enabled a fourfold increase in
o medical content creation.
Commencement of a pro-bono AI navigation agent pilot in partnership with Open Dialogue, to enable patients
to query Info Hub content in a personalised, conversational format
Growth of website traffic to 3,200 visits over the period, driven by the charity's content pipeline and referrals
o from patients, clinicians and patient advocacy communities
Fundraising from individual donors to support the development of the charity's infrastructure and enable the
next stage of growth.

Public benefit

The trustees confirm that they have had regard to the Charity Commission's guidance on public benefit when planning and reviewing the charity's activities. They are satisfied that the activities described in this report demonstrate how the charity has delivered public benefit in line with its charitable objects.

Hard-to-treat cancers, which include rare, aggressive and late-stage diagnoses, account for over 52% of yearly cancer diagnoses in the UK. Yet patients who have exhausted standard treatment options frequently encounter a lack of accessible, unbiased information about what other options may exist. ACT for Cancer exists to address this information gap. All the charity's services are provided free of charge and are open to anyone; there are no financial or membership barriers to accessing the ACT Info Hub or the charity's guidance.

ACHIEVEMENTS AND PERFORMANCE

Charitable activities

The trustees are pleased to report that ACT for Cancer made good progress in advancing its charitable objectives during this inaugural period, despite operating with very limited financial resources. The primary achievement has been the continued development and expansion of the ACT Info Hub. The implementation of AI-assisted content generation tools will enable the charity to produce medical content at a faster rate than previously managed. A first tranche of new and reviewed articles is scheduled for publication in early 2026, following sign-off by the charity's Medical Editor.

Academic and research contributions have placed ACT for Cancer within credible professional and scientific networks. Research published during the period examines the barriers patients face when navigating cancer care beyond standard treatment, directly supporting the charity's mission and evidencing its public benefit.

The charity attracted 3,200 website visits during the period, driven by its content pipeline and word-of-mouth referrals. Users reach the resource via internet search, patient forums, word of mouth and clinical referrals.

The trustees are satisfied that meaningful foundations have been laid during this first period, and that the charity is well placed to deliver greater impact in the coming financial year as resources grow.

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ACT FOR CANCER

REPORT OF THE TRUSTEES for the period 20 September 2024 to 30 September 2025

ACHIEVEMENTS AND PERFORMANCE

Fundraising activities

Fundraising during the period was carried out by the trustees and the Chair, drawing on personal networks and existing relationships. Total income of £64,561 was received, comprising individual donations (£55,318), Gift Aid reclaims (£432 in the year with £6,500 outstanding at the year end) and grants (£2,311). The charity is grateful to all those who supported its work during this formative period.

The charity explored appointing a fundraising professional during the period; however, the arrangement was concluded at an early stage when it became clear it would not provide sufficient value for the charity's limited resources. As a result, the charity has not yet been able to appoint a dedicated fundraising role. The trustees have therefore taken responsibility for fundraising activities while continuing to work towards building sustainable income that will support future fundraising capacity.

2024 - 2025 Highlights

The charity's first formal trustee board meeting was held in February 2025, establishing the board's governance framework and strategic priorities.
One academic poster and one White Paper authored on behalf of ACT for Cancer were published or presented in peer-reviewed settings, including at the Festival of Genomics and Biodata.
Continued research work on 'Navigating cancer treatment beyond standard of care: Understanding patient access' study
An AI-assisted medical content generation system was successfully implemented, creating medical content at four times the previous rate which will accelerate the development of the Info Hub.
During the period, the trustees recruited a fundraising professional to support income generation. Following an initial trial period, it became clear that the arrangement was not delivering the expected return on investment, and the role was therefore concluded amicably in order to avoid further expenditure
A pro bono AI navigator pilot project was initiated with Open Dialogue, providing ACT's content as the foundation for a patient-facing conversational and signposting tool.
Website traffic grew to 3,200 visits over the period, with no paid promotion.
In the charity's first year as a registered CIO, the total income of £64,561 was received from individual donors, Gift Aid and grants.
Net income for the period was £43,819, with £46,961 held in current assets at the period end

FINANCIAL REVIEW

Financial position

Total incoming resources for the period were £64,561, comprising donations (£55,318), Gift Aid (£432 with £6,500 debtor at the year end) and grants (£2,311). Total expenditure was £20,742, of which the majority was applied directly to charitable activities including medical content production (£8,325), staff wages and pensions (£8,851), training (£201) and other operational costs. Support costs of £2,417 comprised bank charges and accountancy and governance fees.

At the balance sheet date of 30 September 2025, the charity held cash at bank of £40,461, along with £6,500 of Debtors. Creditors of £3,142 falling due within one year comprise taxation and social security liabilities and other creditors. Net assets at the period end were £43,819, of which £37,231 is held as unrestricted general funds and £6,588 as restricted funds.

The trustees consider the charity to be financially stable as a going concern. There are no material uncertainties about the charity's ability to continue in operation.

Principal funding sources

During this period, the charity was funded entirely through voluntary income, comprising donations from individuals, Gift Aid reclaims and grants. The trustees anticipate that future income will be generated through a combination of individual giving, fundraising events, grant applications and, in due course, corporate partnerships and philanthropic foundations.

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ACT FOR CANCER

REPORT OF THE TRUSTEES for the period 20 September 2024 to 30 September 2025

FINANCIAL REVIEW

Investment policy and objectives

ACT for Cancer does not currently hold any investments quoted on a stock exchange. All surplus funds are held in cash at bank. The trustees will review this policy as the charity's reserves grow.

Reserves policy

The trustees have not yet formally adopted a written reserves policy, as the charity is in its first year of operation. The trustees are committed to developing and adopting a formal reserves policy during the next financial year.

As an interim position, the trustees consider that a minimum reserve equivalent to three to six months of core operating costs would be an appropriate target. At the period end, the charity's unrestricted reserves of £30,731 broadly meet this interim threshold. Restricted funds of £6,588 are not available for general purposes and are excluded from the reserves calculation. The trustees will review and formally adopt a reserves policy in the next financial year.

FUTURE PLANS

The trustees have identified the following priorities for the financial year ending 30 September 2026.

ACT Info Hub and AI navigator agent development

A first tranche of new and reviewed articles, produced using AI-assisted content generation tools, is scheduled for publication in early 2026. The trustees intend to develop and launch a patient-facing AI navigation agent, in partnership with Open Dialogue, enabling users to query the Info Hub in a personalised conversational format. A working prototype is anticipated within the next 12 months, subject to available funding. The website will also be redesigned to improve accessibility and navigation for the charity's three core audiences: patients, caregivers and clinicians.

Research

Building on the research published in 2025, the charity intends to progress to a further phase of its study into barriers to cancer care beyond standard treatment. This phase will examine inequities across demographic groups including gender, ethnicity, age and socioeconomic background. Findings will be published and used to strengthen the charity's advocacy work.

Fundraising and income growth

A key priority is to grow the charity's income base towards the level required to employ dedicated full-time resources. The trustees have set a target of raising approximately £100,000 per year to cover core operating costs. The trustees intend to pursue this through fundraising events, major donor cultivation and grant applications. A fundraising event is planned during 2026 as a key step towards the income target.

Governance and board development

The trustees intend to strengthen the board during the coming year by recruiting additional trustees with complementary skills, particularly in the areas of fundraising, finance and clinical or scientific expertise. This is considered essential to the charity's long-term sustainability and governance.

STRUCTURE, GOVERNANCE AND MANAGEMENT

Governing document

The charity is controlled by its governing document, a constitution, and is a Charitable Incorporated Organisation (CIO).

Recruitment and appointment of new trustees

Trustees are appointed by the board following an informal process of identification and approach, drawing on the personal and professional networks of existing trustees. Prospective trustees are assessed against the skills and experience needs of the board at the relevant time, with the aim of ensuring that the board collectively holds the range of competencies required to govern the charity effectively. The minimum number of trustees required under the governing document is three. At the period end, the charity had four trustees in post.

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ACT FOR CANCER

REPORT OF THE TRUSTEES for the period 20 September 2024 to 30 September 2025

STRUCTURE, GOVERNANCE AND MANAGEMENT Organisational structure

The charity is governed by its board of trustees, who meet formally at least twice per year and communicate regularly between meetings. The trustees hold collective responsibility for the strategic direction, governance and financial oversight of the charity.

Day-to-day operational activities are led by the Co-Founder and Chair, Marje Isabelle, who also serves as the charity's principal point of contact for external relationships. Medical content and research activities are led by the Medical Editor and Content Lead, Sharmin Begum, working as a contractor. The charity's President, Dr Jack Kreindler, contributes clinical expertise and supports strategic direction and fundraising in a voluntary capacity.

The charity does not currently employ any permanent full-time staff. This is a key constraint on operational capacity and addressing it remains a strategic priority.

Induction and training of new trustees

New trustees are required to complete the Charity Commission's trustee declaration and to register with the Charity Commission prior to taking up their role. On appointment, new trustees receive an induction covering the charity's purposes, activities and governance arrangements, and are directed to the Charity Commission's guidance on trustee responsibilities, including the Commission's Welcome Pack for New Trustees. Trustees are encouraged to undertake appropriate ongoing training and development in their role.

Related parties and co-operation with other organisations

None of the trustees receive remuneration or other benefit from their work as trustees of the charity. Only expenses properly incurred in the performance of trustee duties may be reimbursed. Any connection between a trustee or a member of staff and a related party must be disclosed in the same way as any other contractual relationship. There were no related party transactions during the period requiring disclosure.

Risk management

The trustees have a duty to identify and review the risks to which the charity is exposed and to ensure appropriate controls are in place to provide reasonable assurance against fraud and error.

The trustees have identified the principal risks facing the charity, which at this early stage of development include:

dependency on a small number of income sources;
limited operational capacity in the absence of full-time paid staff
reputational risk associated with the accuracy of the medical information published on the Info Hub

To mitigate these risks, the trustees have moved towards taking following steps:

the Info Hub content is subject to medical editorial review before publication
the charity's finances are independently examined by a qualified external examiner
the trustees are actively working to diversify income sources and strengthen the board

The trustees will develop a formal Risk Register during the next financial year.

REFERENCE AND ADMINISTRATIVE DETAILS Registered Charity number

1210147

Principal address

Unit 3 42 Orchard Road Highgate London N6 5TR

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ACT FOR CANCER

REPORT OF THE TRUSTEES

for the period 20 September 2024 to 30 September 2025

Trustees

M Isabelle (appointed 20.9.24) M Fincham (appointed 7.2.25) A Crockett (appointed 20.9.24) O Gottlieb (appointed 20.9.24)

Independent Examiner

Christopher Marsh FMAAT Marsh Solutions Limited 82 Berechurch Hall Road Colchester Essex CO2 8RF

STATEMENT OF TRUSTEES' RESPONSIBILITIES

The trustees are responsible for preparing the Report of the Trustees and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

Charity law requires the trustees to prepare financial statements for each financial year. Under that law, the trustees have elected to prepare the financial statements in accordance with United Kingdom Generally Accepted Accounting Practice (United Kingdom Accounting Standards and applicable law).

Under charity law the trustees must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the charity and of the incoming resources and application of resources, including the income and expenditure, of the charity for that period. In preparing those financial statements, the trustees are required to

select suitable accounting policies and then apply them consistently;
observe the methods and principles in the Charities SORP;
make judgements and estimates that are reasonable and prudent;
prepare the financial statements on the going concern basis unless it is inappropriate to presume that the charity will continue in business.

The trustees are responsible for keeping proper accounting records which disclose with reasonable accuracy at any time the financial position of the charity and to enable them to ensure that the financial statements comply with the Charities Act 2011 and The Charity (Accounts and Reports) Regulations 2008. They are also responsible for safeguarding the assets of the charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

30/03/2026

Approved by order of the board of trustees on ............................................. and signed on its behalf by:

.................................................................... M Isabelle - Trustee

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INDEPENDENT EXAMINER'S REPORT TO THE TRUSTEES OF ACT FOR CANCER

Independent examiner's report to the trustees of Act for Cancer

I report to the charity trustees on my examination of the accounts of Act for Cancer (the Trust) for the period 20 September 2024 to 30 September 2025.

Responsibilities and basis of report

As the charity trustees of the Trust you are responsible for the preparation of the accounts in accordance with the requirements of the Charities Act 2011 ('the Act').

I report in respect of my examination of the Trust's accounts carried out under Section 145 of the Act and in carrying out my examination I have followed all applicable Directions given by the Charity Commission under Section 145(5)(b) of the Act.

Independent examiner's statement

I have completed my examination. I confirm that no material matters have come to my attention in connection with the examination giving me cause to believe that in any material respect:

accounting records were not kept in respect of the Trust as required by Section 130 of the Act; or
the accounts do not accord with those records; or
the accounts do not comply with the applicable requirements concerning the form and content of accounts set out in the Charities (Accounts and Reports) Regulations 2008 other than any requirement that the accounts give a true and fair view which is not a matter considered as part of an independent examination.

I have no concerns and have come across no other matters in connection with the examination to which attention should be drawn in this report in order to enable a proper understanding of the accounts to be reached.

Christopher Marsh FMAAT The Association of Accounting Technicians

Marsh Solutions Limited 82 Berechurch Hall Road Colchester Essex CO2 8RF 02/04/2026 Date: .............................................

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ACT FOR CANCER

STATEMENT OF FINANCIAL ACTIVITIES

for the period 20 September 2024 to 30 September 2025

Unrestricted Restricted fund fund Notes £ £ INCOME AND ENDOWMENTS FROM Donations and legacies 56,901 7,660 EXPENDITURE ON Charitable activities Charitable activities 19,670 1,072 NET INCOME 37,231 6,588 TOTAL FUNDS CARRIED FORWARD 37,231 6,588	Total funds £ 64,561 20,742 43,819 43,819

CONTINUING OPERATIONS

All income and expenditure has arisen from continuing activities.

The notes form part of these financial statements

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ACT FOR CANCER

BALANCE SHEET 30 September 2025

Unrestricted Restricted fund fund Notes £ £ CURRENT ASSETS Debtors 3 6,500 - Cash at bank 33,873 6,588 40,373 6,588 CREDITORS Amounts falling due within one year 4 (3,142) - NET CURRENT ASSETS 37,231 6,588 TOTAL ASSETS LESS CURRENT LIABILITIES 37,231 6,588 NET ASSETS 37,231 6,588 FUNDS 5 Unrestricted funds Restricted funds TOTAL FUNDS	Total funds £ 6,500 40,461 46,961 (3,142) 43,819 43,819 43,819 37,231 6,588 43,819

The financial statements were approved by the Board of Trustees and authorised for issue on ............................................. and were signed on its behalf by: 30/03/2026

............................................. M Isabelle - Trustee

The notes form part of these financial statements

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ACT FOR CANCER

NOTES TO THE FINANCIAL STATEMENTS for the period 20 September 2024 to 30 September 2025

1. ACCOUNTING POLICIES

Basis of preparing the financial statements and assessment of going concern

The financial statements of the charity, which is a public benefit entity under FRS 102, have been prepared in accordance with the Charities SORP (FRS 102) 'Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019)', Financial Reporting Standard 102 'The Financial Reporting Standard applicable in the UK and Republic of Ireland' and the Charities Act 2011. The financial statements have been prepared under the historical cost convention.

The trustees consider that there are no material uncertainties about the charity's ability to continue as a going concern.

The financial statements are presented in sterling (£).

Income

All income is recognised in the Statement of Financial Activities once the charity has entitlement to the funds, it is probable that the income will be received and the amount can be measured reliably.

Expenditure

Liabilities are recognised as expenditure as soon as there is a legal or constructive obligation committing the charity to that expenditure, it is probable that a transfer of economic benefits will be required in settlement and the amount of the obligation can be measured reliably. Expenditure is accounted for on an accruals basis and has been classified under headings that aggregate all cost related to the category. Where costs cannot be directly attributed to particular headings they have been allocated to activities on a basis consistent with the use of resources.

Taxation

The charity is exempt from tax on its charitable activities.

Debtors

Trade and other debtors are recognised at the settlement amount. Prepayments are valued at the amount prepaid.

Cash at bank and in hand

Cash at bank and in hand includes cash, current bank accounts and deposit bank accounts with no withdrawal limitations.

Creditors

Creditors are recognised where the charity has a present obligation resulting from a past event that will result in the transfer of funds to a third party and the amount due to settle the obligation can be measured or estimated reliably. Creditors are recognised at their settlement amount.

Fund accounting

Unrestricted funds can be used in accordance with the charitable objectives at the discretion of the trustees.

Restricted funds can only be used for particular restricted purposes within the objects of the charity. Restrictions arise when specified by the donor or when funds are raised for particular restricted purposes.

Further explanation of the nature and purpose of each fund is included in the notes to the financial statements.

Pension costs and other post-retirement benefits

The charity operates a defined contribution pension scheme. Contributions payable to the charity's pension scheme are charged to the Statement of Financial Activities in the period to which they relate.

continued...

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ACT FOR CANCER

NOTES TO THE FINANCIAL STATEMENTS - continued for the period 20 September 2024 to 30 September 2025

2. TRUSTEES' REMUNERATION AND BENEFITS

There were no trustees' remuneration or other benefits for the period ended 30 September 2025.

Trustees' expenses

There were no trustees' expenses paid for the period ended 30 September 2025.

3. DEBTORS: AMOUNTS FALLING DUE WITHIN ONE YEAR

Gift Aid 4. CREDITORS: AMOUNTS FALLING DUE WITHIN ONE YEAR Taxation and social security Other creditors	£ 6,500 £ 1,789 1,353 3,142

5. MOVEMENT IN FUNDS

	Net
	movement	At
	in funds	30.9.25
	£	£
Unrestricted funds
General fund	37,231	37,231
Restricted funds
Restricted Funds	6,588	6,588
TOTAL FUNDS	43,819	43,819

Net movement in funds, included in the above are as follows:

	Incoming	Resources	Movement
	resources	expended	in funds
	£	£	£
Unrestricted funds
General fund	56,901	(19,670)	37,231
Restricted funds
Restricted Funds	7,660	(1,072)	6,588
TOTAL FUNDS	64,561	(20,742)	43,819

continued...

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ACT FOR CANCER

NOTES TO THE FINANCIAL STATEMENTS - continued

for the period 20 September 2024 to 30 September 2025

6. RELATED PARTY DISCLOSURES

There were no related party transactions for the period ended 30 September 2025.

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