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2023-01-31-accounts

Registered number: CE028473 Charity number: 1198095

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

UNAUDITED

TRUSTEES' REPORT AND FINANCIAL STATEMENTS

FOR THE YEAR ENDED 31 JANUARY 2023

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

CONTENTS

Page
Reference and Administrative Details of the Charity, its Trustees and Advisers 1
Trustees' Report 2 - 9
Trustees' Responsibilities Statement 10
Independent Examiner's Report 11 - 13
Statement of Financial Activities 14
Balance Sheet 15 - 16
Notes to the Financial Statements 17 - 29

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

REFERENCE AND ADMINISTRATIVE DETAILS OF THE CHARITY, ITS TRUSTEES AND ADVISERS FOR THE YEAR ENDED 31 JANUARY 2023

Trustees N Corrigan, Chair
G C Corrigan
T P Morement
H Corrigan
Company registered
number
CE028473
Charity registered
number
1198095
Registered office
Enterprise House
Bassingbourn Road
Stansted
Essex
CM24 1QW
Accountants
Haslers
Chartered Accountants
Old Station Road
Loughton
Essex
IG10 4PL

Page 1

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT FOR THE YEAR ENDED 31 JANUARY 2023

The trustees present their report with the financial statements of the charity for the year ended 31 January 2023. The trustees have adopted the provisions of Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).

AMMF – The Cholangiocarcinoma Charity was registered with the Charity Commission as a Charitable Incorporated Organisation (CIO) during the year 2022. The CIO registered number with the Charity Commission is 1198095.

The charity was originally registered in 2002 under the name, The Alan Morement Memorial Fund (working title, AMMF) and was an unincorporated charity with the registration number 1091915.

However, because of the continuing growth of the charity, AMMF’s trustees decided that it should transition as a legal entity from unincorporated registered charity status to that of a Charitable Incorporated Organisation (CIO). This involved lengthy work with the Charity Commission, and the new CIO status was approved on 01 June, 2022. At that point the work and all assets of the original charity passed to the new CIO charity.

The original charity and its registered number 1091915 will always remain in existence, with all records submitted to the Charity Commission still available on the Commission’s website, but this entity will now remain in the background.

The new CIO is officially known as: AMMF – The Cholangiocarcinoma Charity, with the registered number: 1198095.

The aims and objectives of AMMF remain unchanged and the charity’s work has and will continue seamlessly and without interruption.

The trustees present their report with the financial statements of the charity for the year ended 31 January 2023. The trustees have adopted the provisions of Accounting and Reporting by Charities:

Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).

OBJECTIVES AND ACTIVITIES

Objectives and aims

AMMF – the Cholangiocarcinoma Charity is the only charity in the UK solely dedicated to cholangiocarcinoma (bile duct cancer). AMMF works nationally throughout the UK, as well as in Europe, and collaborates globally.

AMMF is wholly committed to tackling the devastating cancer, cholangiocarcinoma (CCA), on all fronts and, ultimately, to help find a cure, through:

Page 2

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

Cholangiocarcinoma is under-represented and under-funded across all areas, including policy, services, and research. It is a poorly understood and under researched disease which is increasing in incidence not only in the UK but throughout the world. Lack of awareness and the difficulties of achieving clear and accurate diagnosis, mean that most are at an advanced stage and inoperable at time of diagnosis.

Surgery remains the only potentially curative treatment - there is palliative chemotherapy and there are a growing number of clinical trials, in particular investigating targeted therapies and immunotherapy - but a diagnosis of inoperable cholangiocarcinoma remains invariably fatal, and this is a situation that has not changed in decades. AMMF is committed to working to change this scenario and strongly believes international collaboration is the way forward.

Resolute in bringing about improvement for the cholangiocarcinoma patient, AMMF continues to work closely with patients and their carers, clinicians, healthcare professionals, researchers, and policy makers, as well as actively collaborating globally.

During the year 2022, the charity continued its advocacy work, especially in helping those with cholangiocarcinoma to navigate their way to continue essential treatments wherever possible.

AMMF’s MISSION

A world improved for the cholangiocarcinoma patient by the sharing of knowledge across the healthcare and research communities and with the family of affected people across the globe.

AMMF’s VISION

A world where people can live their lives free of cholangiocarcinoma (CCA) as a life-threatening disease.

Raising Awareness

Cholangiocarcinoma Data Analysis Project

.

Lack of robust data for cholangiocarcinoma has long been seen by AMMF as a major reason why there is so little awareness of this cancer, and so little progress. Robust data are essential to drive policy, to encourage research funding, to stimulate interest, and so much more.

. Working towards rectifying this, Helen Morement, CEO of AMMF, along with Professor Shahid Khan, a hepatologist, and Professor Mireille Toledano, an epidemiologist, both of Imperial College London, prepared a cholangiocarcinoma data project proposal which was submitted to and accepted by the National Cancer Registration and Analysis Service (NCRAS) and Public Health England (PHE) and, in 2019, AMMF entered into a partnership with NCRAS and PHE, employed a data analyst specifically for this work, and the project began

After PHE completed the first part of the project, rather than directly employ another analyst, during the latter part of 2020 AMMF placed the work with the agency Health Data Insight (HDI ), who worked closely with PHE on AMMF’s behalf. The work continued throughout 2021 and 2022.

Dr Sophie Jose, Senior Analyst at HDI, presented the data project findings to that point at AMMF’s conference in May 2022. Key points were:

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

The CCA data project work completed late in 2022 and then, with AMMF, the PHE and HDI teams began the preparation of three manuscripts for publication during 2023:

AMMF’s Hybrid Cholangiocarcinoma Conference 2022

The 2022 conference, held 11-13 May, marked 20 years since the inception of AMMF, and brought together an expert faculty of speakers who reflected over those two decades to measure the progress made, and looked to the future and the work that is still to be done.

Although in the UK, the relaxation of the rules and limitations of surrounding the COVID-19 pandemic made live events possible again, many were still not travelling internationally. So the decision was made to hold AMMF’s annual cholangiocarcinoma conference as a hybrid event – face to face at the Radisson Blu Hotel, Stansted, with care taken to ensure the event would be as COVID-safe as possible, but also with the option for those still under travel limitations, or through choice, to attend virtually as the event would be simultaneously streamed across the world.

AMMF was delighted to welcome two internationally renowned specialists at the forefront of the CCA world, Professor Juan Valle (UK) and Professor Jesus Bañales (Spain), to co-chair the anniversary event. They expertly hosted speakers from across the globe who explored UK, European and international aspects of CCA, and enabled the delivery of an inspirational event.

The conference was open to all with an interest in CCA, including specialists, scientists, researchers, clinical nurse specialists, members of the pharmaceutical industry, medical students, patients and carers. More than 600 delegates, including 130 attendees at the Radisson Blu, from six continents registered and over the three days 37 presentations were delivered, plus 14 interactive Q&A sessions. Throughout each day, health care professionals were able to visit a virtual poster hall to see and hear 15 poster presentations, and also to visit the virtual exhibition hall to meet AMMF’s sponsors, supporters and representatives of fellow CCA societies from around the world.

As well as presenters from across the UK and Europe who gave updates on treatments and clinical trials, there were presentations giving international insights from China and Southeast Asia.

Scientific updates were delivered by researchers from several of the projects funded by AMMF and these, as

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

well as the scientific updates on experimental modelling and the future of AI, shone a light on the efforts that are being made to understand the complexity of CCA and to develop new diagnostic tools and therapies which will hopefully lead to improved patient outcomes. There were also a number of presentations specifically highlighting the growing number of UK institutions who are now focusing on cholangiocarcinoma.

All the 2022 conference sessions were recorded and remain available to view via AMMF’s website. https://ammf.org.uk/ammf-conference-2022/

AMMF’s European Language Website

AMMF is committed to supporting those with cholangiocarcinoma and, living in a multicultural, multilingual society, it was decided to provide translations of generic sections of AMMF’s existing, main website to give as many as possible of those with CCA the support they need and deserve through greater access to the information and resources AMMF provides.

Developed throughout 2021, AMMF’s European language website site was formally launched on World Cholangiocarcinoma Day, 12 February 2022. This website is available in 8 European languages – Spanish, French, German, Italian, Polish, Portuguese, Danish, Finnish. www.ammf-eu.org

AMMF Patient Advisory Roundtables

Two patient advisory roundtables were held during 2022, the first on 25 April, the second, a follow up one, was held on 12 July. These were to discuss clinical trials with patients, and to understand how trials are perceived, and also to better understand the impact a diagnosis of CCA has on patients’ lives and where there might be areas of unmet need. Reports of the findings were circulated to patients and to the supporting pharmaceutical company, and discussions are ongoing.

Virtual Lab Tour with University of Edinburgh

Over several years, AMMF has funded areas of CCA research work at the University of Edinburgh. In acknowledgement of that, and as one of February’s Cholangiocarcinoma Awareness month events, the team in Edinburgh organised a virtual lab tour and a Q&A session on 09 February 2022, for CCA patients and AMMF supporters. This showcased the scope of the work they have been able to undertake as a result of the funding, and to explain some of the findings. This proved a valuable exercise for all attendees both in the terms of learning much more about the painstaking reality of research, and in seeing how important, appreciated and well used supporters’ donations are.

The Global Cholangiocarcinoma Alliance

Building on the foundation of three successful annual World Cholangiocarcinoma Days, a venture which was initially an AMMF-instigated initiative, The Global Cholangiocarcinoma Alliance (GCA) was established at AMMF’s international workshop held in London in 2018. This Alliance aims to provide a united voice through international collaboration, to seek further ways to drive awareness and education globally, and to address the current challenges in cholangiocarcinoma.

Since that time, AMMF continued to work with the agency Scientific Education Support (SES), acting as the notfor-profit partner as the work towards formalising a governance structure and the formation of an international steering committee was completed.

The international steering committee provided direction and content recommendations for all aspects and initiatives of the GCA. The work has included the annual World Cholangiocarcinoma Day and the development of a dedicated website, designed to provide the global cholangiocarcinoma community with a platform on which to build links and exchange knowledge in order to raise the global awareness of CCA and improve the education of both healthcare professionals and patients.

Page 5

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

As the ‘not for profit’ partner for the GCA, and after almost five years of working with the agency Scientific Education Support, it was decided that AMMF should exercise due diligence. A Request for Proposal (RFP) process for the work of the GCA was carried out, and the agency AXON have now taken over the work of the alliance. AMMF remains the not for profit partner.

PUBLIC BENEFIT

In forming the charity’s objectives and planning the activities, the trustees have considered the Charity Commission’s guidance in respect of public benefit.

ACHIEVEMENT AND PERFORMANCE

AMMF remains committed to supporting research into cholangiocarcinoma and opened its grant funding round again in March 2022, following a period during the pandemic when the charity was closed to new applications.

Over the last year several existing awardees requested no cost extensions because the closure of their laboratories during the pandemic, which had resulted in delays to finalizing research work.

Nine applications were accepted during the 2022 round, and were reviewed by AMMF’s Scientific Advisory Board. The following are those that were successful, and have been offered and accepted the grant funding as noted:

To fund research into, “The role of THBS1, THBS2 and PEDF in the lymphatic dissemination of the intrahepatic cholangiocarcinoma: identification of downstream signalling” Total request: £35,000. Award: £35,000 (in two instalments)

! University of Copenhagen (Professor Jesper B Andersen) AMMF Ref: 2022/212

To fund work on, “Tumour phenotypes and sensitivities triggered by IL-6 activation in intrahepatic cholangiocarcinoma” Total request: £45,339. Award: £45,339.00 (in one instalment)

To fund research into, “Single-molecule multiplexed detection of biomarkers for HCC and CCA using a novel nanopore-based sensing”. Total request: £27,625.78. Award: £27,625.78 (in one instalment)

! U niversity of Nottingham (Kevin Gaston, Sheela Jayaraman, Isioma Egbuniwe) AMMF Ref: 2022/214

To fund research into, “Ultra high-resolution mapping of spatial patterns of gene and protein expression in cholangiocarcinoma and the cholangiocarcinoma tumour microenvironment”. Total request: £48,500. Award: £24,250.00

To rund research into, “Intrahepatic cholangiocarcinoma hidden amongst the unknown: biomarker discovery and

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

novel diagnostic approach from circulation: Free DNA (cfDNA) in cancers of unknown primary”. Total request: £110,695.94. Award: £30,850.00

During 2022 the following payments were made re new and existing awards:

University of Liverpool - £23,789.84 was requested and paid on 16.02.2022. This single payment represents the full amount re the award (of £25,000) agreed to fund the work of Dr Marc Quinn in the identification of actionable drug targets in perihilar cholangiocarcinoma using a whole exome sequencing approach.

University of Edinburgh. £33,365.00 was paid on 20.05.2022 in respect of the 3rd and final instalment of the award of £102,595 agreed in September 2017 to fund a 3 year PhD scholarship in Dr Luke Boulter's lab, for the project, " Understanding the role of seed cells and epithelian co-option in cholangiocarcinoma."

University of Copenhagen - £45,339.00 was paid 07.12.2022, representing the full amount of the award agreed to fund the work of Professor Jesper Andersen on “Tumour phenotypes and sensitivities triggered by IL-6 activation in intrahepatic cholangiocarcinoma”.

Imperial College London - £27,625.78 was paid on 14.12.2022, representing the full amount of the award agreed to fund the work of Professor Shahid Khan’s team in the detection of single-molecule multiplexed detection of biomarkers for HCC and CCA using a novel nanopore-based sensing.

University of Leeds – a final payment of £3,345.09 was made on 09.01.2023 against invoiced actual consumable spend in respect of an award of £45,000 which was agreed in July 2018 to be given over three years, to fund consumables required in the work of Dr Stephen Griffin on virus-driven intrahepatic cholangiocarcinoma.

Donostia University Hospital, Spain - £10,225.00 (3rd and final instalment) was paid in Euros on 09.01.2023 in respect of an award of £32,048.00 agreed in 2019 to be given in 3 instalments to fund Dr Jesus Bañales’s work on the role of the transcription factor KLF5 in the etiopathogenesis of cholangiocarcinoma, a new diagnostic, prognostic and therapeutic strategy.

AMMF’s External Activities

AMMF is recognized widely, nationally and internationally, amongst both the general public and within medical circles, for its work in the field of cholangiocarcinoma, and is frequently invited to become part of study groups and advisory boards, for example, the working group for Liver Transplantation for Cholangiocarcinoma, and the executive committee of Cholangiocarcinoma-UK.

During the year, AMMF was involved with the new British Society of Gastroenterology (BSG) Guidelines for the Diagnosis and Management of Cholangiocarcinoma. Along with a number of CCA specialists, led by Professor Shahid Khan, who have all written on their specialisms, AMMF’s CEO contributed a chapter, “Patient/Public Perspective” which is included in this new work.

AMMF is also a member of the European Network for the Study of Cholangiocarcinoma (ENS-CCA), an association of research groups from across Europe and beyond, actively working on basic, translational, and clinical research into cholangiocarcinoma, and AMMF’s CEO is chair of the ENS-CCA Patient Advocacy Committee.

AMMF continues to be an active member of Cancer52, the alliance of rare and less common cancer organisations in the UK. AMMF’s CEO, Helen Morement was appointed a board director of Cancer52 in 2014, and has continued in that role since then. She also acted as interim co-chair during the year (with fellow Cancer52 board member, Rebecca Porta, CEO of The Urology Foundation) whilst a new chair of trustees was sought. Through membership of Cancer52, AMMF is enabled to have a presence and a voice within every national cancer initiative and AMMF’s trustees see this as providing an important opportunity to work more

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

closely with this increasingly influential organisation, and in identifying priority challenges and opportunities for all those in the rare and less common cancers community.

During the year, AMMF’s CEO attended and presented at a number of meetings and conferences, including presenting the work of AMMF at the Scottish Annual Hepatobiliary (HPB) Conference, speaking on the topic of “Hepatobiliary Cancers – from the Patient Advocate’s Point of View” at the National Cancer Research Institute (NCRI) Hepatobiliary Study Group’s annual meeting, and on “The impact of advocacy in cholangiocarcinoma” at the ENS-CCA Annual Conference, held in Edinburgh.

During 2022, AMMF was invited by the National Institute for Health and Care Excellence (NICE) to submit responses as a patient advocacy organisation, and CEO Helen Morement as a patient expert, for four therapies applicable to cholangiocarcinoma, which had been put forward for approval. Written submissions were made, and the appraisals are scheduled to take place at NICE committee meetings during 2023.

(The therapies are: durvalumab (with gemcitabine and cisplatin) Appraisal 4031; Ivosidenib Appraisal 6164; Pembrolizumab (ID4036); Pembrolizumab with gemcitabine and cisplatin (ID4034))

Providing information for those who need it

AMMF’s CEO attended monthly virtual NHS cancer charity briefing meetings throughout 2022. These regular meetings, which began during the pandemic, are now proving informative, hearing about new developments in NHS processes and campaigns in a timely manner. AMMF’s Medical and Clinical Advisors are contacted on a regular basis for help and advice on how best to handle the more difficult patient queries the charity receives, and for up to date information on clinical trials.

AMMF’s website continued to be updated regularly, and aims to provide information on all aspects of cholangiocarcinoma, including treatments and specialists, the advances being made and, importantly, there is a comprehensive list of the clinical trials that are available and recruiting in the UK, which is proving a valuable resource to medics and patients. www.ammf.org.uk

The charity’s active social media platforms kept supporters up to date with information of importance and relevance to them throughout the year. AMMF’s Facebook page now has over 5,700 followers, and the following on Twitter, Instagram and LinkedIn continues to grow.

In answer to patients’ requests, AMMF opened two private, member only, support groups on Facebook - Cholangiocarcinoma Support – UK and Europe, and a group for those bereaved by cholangiocarcinoma. These have been well received and are actively used on a daily basis, proving an invaluable resource for patients to share information, and for them to help and support each other.

The requirement from individual patients and family members for specific information regarding specialist consultants and treatments continues to increase. With the wider awareness of the charity, increasing incidence and growing recognition of cholangiocarcinoma, it is anticipated this area of work will continue to grow.

In summary

All government restrictions to travel and office-based working were lifted by the early part of 2022, and the board of trustees considered it safe for all AMMF staff to resume working full time at AMMF’s Enterprise House offices. However, the COVID situation continued to be monitored on an ongoing basis.

The pandemic caused unforeseen difficulties over the previous two years but, despite the problems, the charity has continued its work steadfastly through the lockdowns, and throughout 2022, expanding its reach and influence nationally and internationally.

As we enter 2023 and the charity’s 21st year since its initial inception, AMMF, the UK’s only cholangiocarcinoma

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

TRUSTEES' REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

charity, is now firmly established in the UK, Europe and beyond. Although by its nature it will remain a niche charity, AMMF has grown steadily over the years and, with the continued help of the loyal fundraisers and supporters, we will continue our work and remain fully committed to working towards a far better future for all those diagnosed with cholangiocarcinoma.

Financial review

The charity has continued to strengthen its financial position during the year.

The charity ensures that sufficient reserves are retained in an appropriate form to fund its current obligations.

Where specific research projects have been secured, the trustees designate sufficient unrestricted reserves to cover the expected future grants payable over the term of the research project.

STRUCTURE, GOVERNANCE AND MANAGEMENT

Governing document

The charity is controlled by its governing document, a deed of trust, and constitutes a CIO.

Approved by order of the members of the board of Trustees on 3 November 2023 and signed on their behalf by:

N Corrigan (Chair of Trustees)

Page 9

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

STATEMENT OF TRUSTEES' RESPONSIBILITIES FOR THE YEAR ENDED 31 JANUARY 2023

The Trustees (who are also the directors of the Charity for the purposes of company law) are responsible for preparing the Trustees' Report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

Company law requires the Trustees to prepare financial statements for each financial . Under company law, the Trustees must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the Charity and of its incoming resources and application of resources, including its income and expenditure, for that period. In preparing these financial statements, the Trustees are required to:

The Trustees are responsible for keeping adequate accounting records that are sufficient to show and explain the Charity's transactions and disclose with reasonable accuracy at any time the financial position of the Charity and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the Charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

Approved by order of the members of the board of Trustees on 3 November 2023 and signed on its behalf by:

N Corrigan (Chair of Trustees)

Page 10

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

INDEPENDENT EXAMINER'S REPORT FOR THE YEAR ENDED 31 JANUARY 2023

Independent Examiner's Report to the Trustees of AMMF - The Cholangiocarcinoma Charity ('the Charity')

I report to the charity Trustees on my examination of the accounts of the Charity for the year ended 31 January 2023.

Responsibilities and Basis of Report

As the Trustees of the Charity (and its directors for the purposes of company law) you are responsible for the preparation of the accounts in accordance with the requirements of the Companies Act 2006 ('the 2006 Act').

Having satisfied myself that the accounts of the Charity are not required to be audited under Part 16 of the 2006 Act and are eligible for independent examination, I report in respect of my examination of the Charity's accounts carried out under section 145 of the Charities Act 2011 ('the 2011 Act'). In carrying out my examination I have followed the Directions given by the Charity Commission under section 145(5)(b) of the 2011 Act.

Page 11

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

INDEPENDENT EXAMINER'S REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

Independent Examiner's Statement

Since the Charity's gross income exceeded £250,000 your examiner must be a member of a body listed in section 145 of the 2011 Act. I confirm that I am qualified to undertake the examination because I am a member of ACCA, which is one of the listed bodies.

I have completed my examination. I confirm that no matters have come to my attention in connection with the examination giving me cause to believe:

  1. accounting records were not kept in respect of the Charity as required by section 386 of the 2006 Act; or

  2. the accounts do not accord with those records; or

  3. the accounts do not comply with the accounting requirements of section 396 of the 2006 Act other than any requirement that the accounts give a 'true and fair' view which is not a matter considered as part of an independent examination; or

  4. the accounts have not been prepared in accordance with the methods and principles of the Statement of Recommended Practice for accounting and reporting by charities [applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102)].

I have no concerns and have come across no other matters in connection with the examination to which attention should be drawn in this report in order to enable a proper understanding of the accounts to be reached.

Page 12

AMMF - THE CHOLANGIOCARCINOMA CHARITY (A Charitable Incorporated Organisation)

INDEPENDENT EXAMINER'S REPORT (CONTINUED) FOR THE YEAR ENDED 31 JANUARY 2023

This report is made solely to the Charity's Trustees, as a body, in accordance with Part 4 of the Charities (Accounts and Reports) Regulations 2008. My work has been undertaken so that I might state to the Charity's Trustees those matters I am required to state to them in an Independent Examiner's Report and for no other purpose. To the fullest extent permitted by law, I do not accept or assume responsibility to anyone other than the Charity and the Charity's Trustees as a body, for my work or for this report.

Signed: P Thain Haslers Chartered Accountants Old Station Road Loughton Essex IG10 4PL

Dated: 3 November 2023

Page 13

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

STATEMENT OF FINANCIAL ACTIVITIES (INCORPORATING INCOME AND EXPENDITURE ACCOUNT) FOR THE YEAR ENDED 31 JANUARY 2023

Note
Income from:
Donations and legacies
3
Other trading activities
4
Investments
5
Total income
Expenditure on:
Raising funds
Charitable activities
6
Total expenditure
Net (expenditure)/income
Transfers between funds
14
Net movement in funds
Reconciliation of funds:
Total funds brought forward
Net movement in funds
Total funds carried forward		 Restricted
funds
2023
£
166,639
-
-
166,639
-
224,686
224,686
(58,047)
24,055
(33,992)
123,738
(33,992)
89,746		 Unrestricted
funds
2023
£
863,852
7,760
1,397
873,009
4,115
471,680
475,795
397,214
(24,055)
373,159
502,965
373,159
876,124		 Total
funds
Combined
2023
£
1,030,491
7,760
1,397
1,039,648
4,115
696,366
700,481
339,167
-
339,167
626,703
339,167
965,870		 Total
funds
Unincorporated
2022
£
821,649
14,055
646
836,350
2,276
627,575
629,851
206,499
-
206,499
420,204
206,499
626,703

The Statement of Financial Activities includes all gains and losses recognised in the year.

The notes on pages 17 to 29 form part of these financial statements.

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation) REGISTERED NUMBER: CE028473

BALANCE SHEET AS AT 31 JANUARY 2023

Note
Fixed assets
Tangible assets
10
Current assets
Stocks
11
Debtors
12
Cash at bank and in hand
Creditors: amounts falling due within one
year
13
Net current assets
Total assets less current liabilities
Total net assets
Charity funds
Restricted funds
14
Unrestricted funds
14
Total funds		 7,386
40,211
971,046
1,018,643
(59,388)		 Combined
2023
£
6,615
6,615
959,255
965,870
965,870
89,746
876,124
965,870		 Unincorporated
2022
£
-
-
7,122
12,144
733,883
753,149
(126,446)
626,703
626,703
626,703
123,738
502,965
626,703		 Unincorporated
2022
£
-
-
7,122
12,144
733,883
753,149
(126,446)
626,703
626,703
626,703
123,738
502,965
626,703		 Unincorporated
2022
£
-
-
7,122
12,144
733,883
753,149
(126,446)
626,703
626,703
626,703
123,738
502,965
626,703
-
626,703
626,703
626,703
123,738
502,965
626,703

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation) REGISTERED NUMBER: CE028473

BALANCE SHEET (CONTINUED) AS AT 31 JANUARY 2023

The Charity was entitled to exemption from audit under section 477 of the Companies Act 2006.

The members have not required the company to obtain an audit for the year in question in accordance with section 476 of Companies Act 2006.

The Trustees acknowledge their responsibilities for complying with the requirements of the Act with respect to accounting records and preparation of financial statements.

The financial statements have been prepared in accordance with the provisions applicable to entities subject to the small companies regime.

The financial statements were approved and authorised for issue by the Trustees on 03 November 2023 and signed on their behalf by:

N Corrigan (Chair of Trustees)

The notes on pages 17 to 29 form part of these financial statements.

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

1. General information

AMMF - The Cholangiocarcinoma Chaity is a charitable incorporated organisation, domiciled in England and Wales, registration number CE028473, charity number 1198095. The registered office is Enterprise House, Bassingbourn Road, Stansted, Essex, CM24 1QW and the principal place of business is throughout the United Kingdom. The principal aim of the charity is to raise awareness of cholangiocarcinoma (bile duct cancer), supply information to those who need it, and to raise funds to support specialised research teams in their work into the causes, methods of earlier diagnosis and treatments of this disease.

2. Accounting policies

2.1 Basis of preparation of financial statements

The financial statements have been prepared in accordance with the Charities SORP (FRS 102) - Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019), the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) and the Companies Act 2006.

AMMF - The Cholangiocarcinoma Charity meets the definition of a public benefit entity under FRS 102. Assets and liabilities are initially recognised at historical cost or transaction value unless otherwise stated in the relevant accounting policy.

2.2 Income

All income is recognised once the Charity has entitlement to the income, it is probable that the income will be received and the amount of income receivable can be measured reliably.

Income tax recoverable in relation to investment income is recognised at the time the investment income is receivable.

2.3 Expenditure

Expenditure is recognised once there is a legal or constructive obligation to transfer economic benefit to a third party, it is probable that a transfer of economic benefits will be required in settlement and the amount of the obligation can be measured reliably. Expenditure is classified by activity. The costs of each activity are made up of the total of direct costs and shared costs, including support costs involved in undertaking each activity. Direct costs attributable to a single activity are allocated directly to that activity. Shared costs which contribute to more than one activity and support costs which are not attributable to a single activity are apportioned between those activities on a basis consistent with the use of resources. Central staff costs are allocated on the basis of time spent, and depreciation charges allocated on the portion of the asset’s use.

Expenditure on raising funds includes all expenditure incurred by the Charity to raise funds for its charitable purposes and includes costs of all fundraising activities events and non-charitable trading.

Expenditure on charitable activities is incurred on directly undertaking the activities which further the Charity's objectives, as well as any associated support costs.

All expenditure is inclusive of irrecoverable VAT.

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

2. Accounting policies (continued)

2.4 Interest receivable

Interest on funds held on deposit is included when receivable and the amount can be measured reliably by the Charity; this is normally upon notification of the interest paid or payable by the institution with whom the funds are deposited.

2.5 Tangible fixed assets and depreciation

Tangible fixed assets are initially recognised at cost. After recognition, under the cost model, tangible fixed assets are measured at cost less accumulated depreciation and any accumulated impairment losses. All costs incurred to bring a tangible fixed asset into its intended working condition should be included in the measurement of cost.

Depreciation is charged so as to allocate the cost of tangible fixed assets less their residual value over their estimated useful lives, using the straight-line method.

Depreciation is provided on the following basis:

Computer equipment - 33%

2.6 Stocks

Stocks are valued at the lower of cost and net realisable value after making due allowance for obsolete and slow-moving stocks. Cost includes all direct costs and an appropriate proportion of fixed and variable overheads.

2.7 Debtors

Trade and other debtors are recognised at the settlement amount after any trade discount offered. Prepayments are valued at the amount prepaid net of any trade discounts due.

2.8 Cash at bank and in hand

Cash at bank and in hand includes cash and short-term highly liquid investments with a short maturity of three months or less from the date of acquisition or opening of the deposit or similar account.

2.9 Liabilities and provisions

Liabilities are recognised when there is an obligation at the Balance Sheet date as a result of a past event, it is probable that a transfer of economic benefit will be required in settlement, and the amount of the settlement can be estimated reliably.

Liabilities are recognised at the amount that the Charity anticipates it will pay to settle the debt or the amount it has received as advanced payments for the goods or services it must provide.

Provisions are measured at the best estimate of the amounts required to settle the obligation. Where the effect of the time value of money is material, the provision is based on the present value of those amounts, discounted at the pre-tax discount rate that reflects the risks specific to the liability. The unwinding of the discount is recognised in the Statement of Financial Activities as a finance cost.

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

2. Accounting policies (continued)

2.10 Fund accounting

General funds are unrestricted funds which are available for use at the discretion of the Trustees in furtherance of the general objectives of the Charity and which have not been designated for other purposes.

Restricted funds are funds which are to be used in accordance with specific restrictions imposed by donors or which have been raised by the Charity for particular purposes. The costs of raising and administering such funds are charged against the specific fund. The aim and use of each restricted fund is set out in the notes to the financial statements.

Investment income, gains and losses are allocated to the appropriate fund.

3. Income from donations and legacies

Donations
Total 2022		 Restricted
funds
Combined
2023
Unrestricted
funds
Combined
2023
£
£
166,639
863,852
140,618
681,031		 Total
funds
Combined
2023
£
1,030,491
821,649		 Total
funds
Unincorporated
2022
£
821,649

4. Income from other trading activities

Income from non charitable trading activities

Unrestricted Total Total
funds funds funds
Combined Combined Unincorporated
2023 2023 2022
£ £ £
Shop income 7,760 7,760 14,055

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

5. Investment income

Unrestricted
funds
Combined
2023
£
Deposit account interest
1,397
Total 2022
646		 Total
funds
Combined
2023
£
1,397
646		 Total
funds
Unincorporated
2022
£
646

6. Analysis of expenditure on charitable activities

Summary by fund type

Costs
Total 2022		 Restricted
funds
Combined
2023
Unrestricted
funds
Combined
2023
£
£
224,686
471,680
38,000
589,575		 Total
Combined
2023
£
696,366
627,575		 Total
Unincorporated
2022
£
627,575

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

7. Analysis of expenditure by activities

Costs
Total 2022		 Activities
undertaken
directly
Combined
2023
£
364,967
232,087		 Support
costs
Combined
2023
£
331,399
395,488		 Total
funds
Combined
2023
£
696,366
627,575		 Total
funds
Unincorporated
2022
£
627,575

Analysis of direct costs

Grants to institutions
European Website costs
European Conference costs
Workshop costs		 Total
funds
Combined
2023
£
155,492
25,841
161,557
22,077
364,967		 Total
funds
Unincorporated
2022
£
194,087
37,790
210
-
232,087

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

7. Analysis of expenditure by activities (continued)

Analysis of support costs

Staff costs
Depreciation
Equipment leasing
Operating lease - office rent & service charges
Rates and water
Insurance
Marketing and advertising
Telephone
Postage and stationery
Computer and website support
Travel
Subscriptions
Sundries
Training
Legal and Professional fees
Conference expenses
Bank charges		 Total
funds
Combined
2023
Total
funds
Unincorporated
2022
£
£
82,158
71,234
948
858
-
2,982
31,195
29,064
1,638
1,638
256
1,068
122,433
115,238
5,562
2,708
3,616
2,005
13,944
21,402
4,050
1,099
1,595
1,449
5
760
215
15
49,931
106,064
13,200
37,288
653
616
331,399
395,488		 Total
funds
Combined
2023
Total
funds
Unincorporated
2022
£
£
82,158
71,234
948
858
-
2,982
31,195
29,064
1,638
1,638
256
1,068
122,433
115,238
5,562
2,708
3,616
2,005
13,944
21,402
4,050
1,099
1,595
1,449
5
760
215
15
49,931
106,064
13,200
37,288
653
616
331,399
395,488
395,488

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

8. Staff costs

Wages and salaries
Social security costs
Contribution to defined contribution pension schemes		 Combined
2023
£
78,173
3,060
924
82,157		 Unincorporated
2022
£
67,958
2,398
877
71,233

The average number of persons employed by the Charity during the year was as follows:

Combined Unincorporated
2023 2022
No. No.
Employees 3 3

No employee received remuneration amounting to more than £60,000 in either year.

9. Trustees' remuneration and expenses

During the year, no Trustees received any remuneration or other benefits (2022 - £NIL) .

During the year ended 31 January 2023, no Trustee expenses have been incurred (2022 - £NIL) .

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

10. Tangible fixed assets

Cost or valuation
At 1 February 2022 Unincorporated
Additions
Disposals
At 31 January 2023
Depreciation
At 1 February 2022 Unincorporated
Charge for the year
On disposals
At 31 January 2023
Net book value
At 31 January 2023
_At 31 January 2022_Unincorporated
Stocks
2023
£
Finished goods and goods for resale
7,386		 Computer
equipment
£
10,305
7,564
(4,291)
13,578
10,305
948
(4,291)
6,962
6,616
-
Unincorporated
2022
£
7,122

11. Stocks

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

12. Debtors

Due within one year
Trade debtors
Other debtors
Prepayments and accrued income		 2023
£
2,190
1,228
36,793
40,211		 Unincorporated
2022
£
-
1,228
10,916
12,144

13. Creditors: Amounts falling due within one year

Trade creditors
Other creditors
Accruals and deferred income		 2023
£
48,530
5,458
5,400
59,388		 Unincorporated
2022
£
123,276
1,370
1,800
126,446

Page 25

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

14. Statement of funds

Statement of funds - current year

Unincorporated
Balance at 1
February 2022
£
Unrestricted funds
General Funds - all funds
502,965
Restricted funds
Restricted Research Funds
21,120
European Website Project
42,828
European Conference 2022
59,790
European Conterence 2023
-
123,738
Total of funds
626,703		 Income
£
873,009
-
16,639
115,000
35,000
166,639
1,039,648		 Expenditure
£
(475,795)
-
(25,841)
(198,845)
-
(224,686)
(700,481)		 Transfers
in/out
£
(24,055)
-
-
24,055
-
24,055
-		 Balance at
31 January
2023
£
876,124
21,120
33,626
-
35,000
89,746
965,870

Restricted research funds represent donations where the donor has requested that their donation be used for research purposes only. These donations are held within restricted funds until used in part or in whole to fund a cholangiocarcinoma research project which the charity has committed to supporting.

Restricted funds for the European website project represent donations where the donor has requested that their donation be used for this project only. These donations are held within restricted funds until used in part or in whole to fund the completion of the European website project.

Restricted funds for the European conference 2022 represent donations where the donor has requested that their donation be used for this conference only. These donations are held within restricted funds until used in part or in whole to fund the European conference 2022.

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AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

14. Statement of funds (continued)

Statement of funds - prior year

Unincorporated
Balance at
1 February
2021
£
Unrestricted funds
General Funds - all funds
399,084
Unincorporated
Balance at
1 February
2021
£
Restricted funds
Restricted Research Funds
21,120
European Website Project
-
European Conference 2022
-
21,120
Total of funds
420,204
15.
Summary of funds
Summary of funds - current year
Unincorporated
Balance at 1
February 2022
£
Income
£
General funds
502,965
873,009
Restricted funds
123,738
166,639
626,703
1,039,648		 Income
£
695,732		 Expenditure
£
(591,851)
Expenditure
£
-
(37,790)
(210)
(38,000)
(629,851)
Transfers
in/out
£
(24,055)
24,055
-		 Expenditure
£
(591,851)
Expenditure
£
-
(37,790)
(210)
(38,000)
(629,851)
Transfers
in/out
£
(24,055)
24,055
-		 Unincorporated
Balance at
31 January
2022
£

502,965
Unincorporated
Balance at
31 January
2022
£
21,120
42,828
59,790
Expenditure
£
-
(37,790)
(210)
(38,000)
(629,851)
Transfers
in/out
£
(24,055)
24,055
-
123,738
626,703
Balance at 31
January 2023
£
876,124
89,746
965,870

Page 27

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

15. Summary of funds (continued)

Summary of funds - prior year

General funds
Restricted funds		 Balance at
1 February 2021
£
399,084
21,120
420,204		 Income
£
695,732
140,618
836,350		 Expenditure
£
(591,851)
(38,000)
(629,851)		 Balance at
31 January
2022
£
502,965
123,738
626,703

16. Analysis of net assets between funds

Analysis of net assets between funds - current year

Tangible fixed assets
Current assets
Creditors due within one year
Total
Analysis of net assets between funds - prior year
Current assets
Creditors due within one year
Total		 Restricted
funds
2023
Unrestricted
funds
2023
£
£
-
6,615
89,746
928,897
-
(59,388)
89,746
876,124
Restricted
funds
2022
Unrestricted
funds
2022
£
£
123,738
629,411
-
(126,446)
123,738
502,965		 Total
funds
2023
£
6,615
1,018,643
(59,388)
965,870
Total
funds
2022
£
753,149
(126,446)
626,703

Page 28

AMMF - THE CHOLANGIOCARCINOMA CHARITY

(A Charitable Incorporated Organisation)

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 JANUARY 2023

17. Related party transactions

The AMMF - The Cholangiocarcinoma Charity has not entered into any related party transaction during the year, nor are there any outstanding balances owing between related parties and the AMMF - The Cholangiocarcinoma Charity at 31 January 2023.

18. Charity merger

This Charity was incorporated on 1st March 2022 for the purpose of continuing the existing charity work of The Alan Morement Memorial Fund registered charity number 1091915 including its purpose and beneficiary class that will remain unchanged.

At midnight on 31st May 2022 The Alan Morement Memorial Fund transfered its charitable undertaking to AMMF - The Cholangiocarcinoma Charity by way of a £746,271 donation as per a transfer agreement written up between the two entities.

As this Charity was set up as the corporate successor of The Alan Morement Memorial Fund we are showing the unincorporated charities figures as prior years comparatives and the current years figures are made up of both the unincorporated and corporated charities combined movements for the year.

Page 29