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2024-12-31-accounts

Charity registration number 1194608

THE CANCER TREATMENT AND RESEARCH TRUST ANNUAL REPORT AND UNAUDITED FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2024

Sobell Rhodes LLP The Kinetic Centre Theobald Street Elstree Borehamwood Hertfordshire WD6 4PJ

THE CANCER TREATMENT AND RESEARCH TRUST

CONTENTS

Page
Trustees report 1 - 9
Statement of trustees responsibilities 10
Independent examiner's report 11
Statement of financial activities 12
Balance sheet 13
Notes to the financial statements 14 - 25

THE CANCER TREATMENT AND RESEARCH TRUST

LEGAL AND ADMINISTRATIVE INFORMATION

Trustees Mr Russell Hallam Dr Paul Nathan Dr A Sharma Dr David Pinato Prof. Michael Seckl Prof. Gordon Rustin Miss Kirandeep Grewal Dr Ehsan Ghorani Charity number 1194608 Principal address Upper East Research Office Mount Vernon Hospital Rickmansworth Road Northwood HA6 2RN Independent examiner Sobell Rhodes LLP The Kinetic Centre Theobald Street Elstree Borehamwood Hertfordshire United Kingdom WD6 4PJ

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT

FOR THE YEAR ENDED 31 DECEMBER 2024

The trustees have adopted the provisions of Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).

STRUCTURE, GOVERNANCE, MANAGEMENT

The Cancer Treatment and Research Trust (CTRT) which was founded in 1985, supports work mainly in the departments of medical oncology at the West London Cancer Centre based at Charing Cross and Hammersmith Hospitals (Imperial College Healthcare NHS Trust) and in the department of medical oncology at the Mount Vernon Cancer Centre, in Northwood, Middlesex.

The charity is a Charitable Incorporated Organisation (CIO) registered with the Charity Commission. It is governed by its constitution, and the trustees are responsible for ensuring compliance with that governing document.

The former unincorporated trust remains on the register solely to manage residual matters arising from the 2022 transition and does not undertake active operations.

� Trustees

The CTRT Board of Trustees is made up of 9 professionals with legal or medical backgrounds as regulated by the deed of trust in line with the Charity Commission regulations. Cancer physicians dominate, in line with the aims of the charity.

In April 2024 Professor Marcia Hall stepped down as chairperson and Professor Michael Seckl was appointed. Professor Hall remained on the board as a trustee and Dr Andreas Polychronis stepped down as a trustee of the charity.

Trustees are appointed in accordance with the charity’s constitution. New trustees receive an induction covering their legal duties, governance processes, and the charity’s key policies. Trustees are required to declare and manage any conflicts of interest in line with the charity’s conflicts policy.

� Administration

On 1st January 2022, CTRT officially transitioned to a Charitable Incorporated Organisation (CIO) status. The original Cancer Treatment and Research Trust (charity number 292909) remains registered as a charity with the Charity Commission, albeit it only remains active in order to manage any residual matters following the 2022 transition.

In January 2024 a new part time Communications Assistant was appointed to support the aims of the charity.

Objectives and activities

The Cancer Treatment and Research Trust (CTRT) which was founded in 1985, supports work mainly in the departments of medical oncology at the West London Cancer Centre based at Charing Cross Hospital and in the department of medical oncology at the Mount Vernon Cancer Centre, in Northwood, Middlesex. The CTRT exists to support treatment and research into many forms of malignant disease and has been particularly involved in understanding how certain cancers develop, finding better ways to monitor them and developing new anti-cancer agents. It remains committed to funding research that is not adequately funded either by the major cancer charities such as CRUK, the MRC or the pharmaceutical industry.

The trustees confirm that they have had due regard to the Charity Commission’s guidance on public benefit when reviewing the charity’s aims, objectives and activities.

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

Achievements and performance

The trustees are pleased with the achievements and performance of the Trust in 2024. In 2024, research, either fully or partly funded by CTRT, led to 42 publications.

The research supported by CTRT can be roughly split into the following areas:

Details about the research, together with the relevant publications and studies, are available on the Trust’s website - cancertreatment.org.uk.

Financial review

Total income for the year was £502,151 (2023: £179,738), derived primarily from donations and investment income. Total expenditure was £142,202 (2023 £223,043), mainly relating to research grants and support costs.

The trustees consider the charity to be a going concern, with sufficient reserves to meet obligations for at least the next 12 months.

Plans for future periods

� Investing in fundraising

In 2024 our new Communications Assistant started work on our social media and email newsletter, increasing our online engagement. We also began work on a redesign of our website to improve functionality and make it easier to donate.

� Plans for research

CTRT will continue to support a diverse variety of research into many cancers including several different types of less common cancers such as ovarian, uterine, melanoma and also very rare cancers such as gestational trophoblast disease, germ cell tumours and rare gynaecological cancers. Our research supports clinical studies as well as laboratory focused work such as developing novel biomarkers. Immunotherapy continues to be a major area of interest in the cancer world and CTRT supports research studying the effects of immunotherapy in trophoblastic, lung and renal cancers.

Details of previous research and further details about existing projects can be found on the website.

RISK MANAGEMENT

The Trustees are aware of the risks affecting the Trust and its work and have ensured that policies are in place to mitigate the effect of these risks.

� Financial risks and Investment

A key aim of the Board is to ensure CTRT holds adequate reserves for working capital purposes and has sufficient funds to meet contractual liabilities and winding down costs, if the organisation were to close. This includes redundancy pay, amounts due to creditors and commitments under contracts. CTRT’s level of reserves also helps the organisation to plan expenditure against variations in the way funding is received. To balance the uncertainty of funding, our policy is to maintain financial reserves to cover these costs and allow for an orderly wind down. The current estimate of these costs is c £50,000. Without current level of support from our individual donors and based on current expenditure levels, CTRT is estimated to still remain in a position to cover these costs for the coming 12 months as our unrestricted reserves stand at about £1.2m.

� Governance structure

The review of governance structure, policies and procedures was commenced and following that review, any recommendations made and agreed upon by the trustees will be implemented in the authorised order.

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

Structure, governance and management

The trustees who served during the year and up to the date of signature of the financial statements were: Mr Russell Hallam

Dr Paul Nathan Dr A Sharma Dr David Pinato Prof. Michael Seckl Prof. Gordon Rustin Miss Kirandeep Grewal Dr Ehsan Ghorani

RESERVES POLICY

Sufficient reserves are maintained to ensure that all running expenses for 3 years as well as future research costs associated with any committed project, are covered in the event no donations are received. CTRT’s running costs are approx. £50,000 a year. It is the policy of CTRT to hold £350,000 in reserve in addition to the costs associated with any committed research projects for this purpose to ensure we can continue operation for up to 3 years and fulfil our commitments until their completion.

At the year end the charity held unrestricted reserves of £1,204,178, which exceeds the minimum level set out in the reserves policy. This reflects planned future research commitments and the trustees’ intention to maintain funding capacity for multi-year projects.

For many years the CTRT received funds to pay for research staff running clinical trials from pharmaceutical companies and trial organisations. Increasingly these funds have been paid directly to support the local NHS Trusts who employ these staff. As of 1st January 2008 the accounts related to Mount Vernon Cancer Centre only include income and expenses actually paid into or out of CTRT accounts.

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

CONCLUSION

Research, either totally or partly funded by the CTRT led to 42 publications in 2024.

  1. Future Directions for Gestational Trophoblastic Disease. Ghorani E, Seckl MJ.Hematol Oncol Clin North Am. 2024 Dec;38(6):1265-1276. doi: 10.1016/j.hoc.2024.08.019. Epub 2024 Sep 24.PMID: 39322464

  2. Defects in meiosis I contribute to the genesis of androgenetic hydatidiform moles. Rezaei M, Liang M, Yalcin Z, Martin JH, Kazemi P, Bareke E, Ge ZJ, Fardaei M, Benadiva C, Hemida R, Hassan A, Maher GJ, Abdalla E, Buckett W, Bolze PA, Sandhu I, Duman O, Agrawal S, Qian J, Vallian Broojeni J, Bhati L, Miron P, Allias F, Selim A, Fisher RA, Seckl MJ, Sauthier P, Touitou I, Tan SL, Majewski J, Taketo T, Slim R.J Clin Invest. 2024 Nov 15;134(22):e170669. doi: 10.1172/JCI170669.PMID: 39545410

  3. Investigating the Regulation of Ribosomal Protein S6 Kinase 1 by CoAlation. Malanchuk O, Bdzhola A, Palchevskyi S, Bdzhola V, Chai P, Pardo OE, Seckl MJ, Banerjee A, Peak-Chew SY, Skehel M, Guruprasad L, Zhyvoloup A, Gout I, Filonenko V.Int J Mol Sci. 2024 Aug 11;25(16):8747. doi: 10.3390/ ijms25168747.PMID: 39201434

  4. Management of patients with rare adult solid cancers: objectives and evaluation of European reference networks (ERN) EURACAN.

Blay JY, Casali P, Ray-Coquard I, Seckl MJ, Gietema J, de Herder WW, Caplin M, Klümpen HJ, Glehen O, Wyrwicz L, Peeters R, Licitra L, Girard N, Piperno-Neumann S, Kapiteijn E, Idbaih A, Franceschi E, Trama A, Frezza AM, Hohenberger P, Hindi N, Martin-Broto J, Schell J, Rogasik M, Lejeune S, Oliver K, de Lorenzo F, Weinman A.Lancet Reg Health Eur. 2024 Feb 16;39:100861. doi: 10.1016/j.lanepe.2024.100861. eCollection 2024 Apr.PMID: 38384730

  1. Chemotherapy is not needed when complete evacuation of gestational choriocarcinoma leads to hCG normalization.

Bolze P, Schoenen S, Margaillan M, Braga A, Sauthier P, Elias K, Seckl M, Winter M, Coulter J, Lok C, Joneborg U, Undurraga Malinverno M, Hajri T, Massardier J, You B, Golfier F, Goffin F.Eur J Surg Oncol. 2024 Mar;50(3):108012. doi: 10.1016/j.ejso.2024.108012. Epub 2024 Feb 8.PMID: 38350264

  1. Effectiveness of adjuvant systemic therapy following complete cytoreductive surgery in patients with recurrent granulosa cell tumours of the ovary.

Yumru Celiksoy H, Dickie C, Seckl MJ, Aydın E, Sozen H, Topuz S, Fotopoulou C.Sci Rep. 2024 Jan 10;14(1):993. doi: 10.1038/s41598-024-51752-x.PMID: 38200105

  1. Guidelines and Multidisciplinary Care Are Essential to Improve Survival Rates and Quality of Life Globally for Women with Gestational Trophoblastic Disease.

Lok C, Seckl M.Gynecol Obstet Invest. 2024;89(3):163-165. doi: 10.1159/000539107. Epub 2024 Apr 26.PMID: 38679007 No abstract available.

  1. PREDICT-GTN 2: Two-factor streamlined models match FIGO performance in gestational trophoblastic neoplasia.

Parker VL, Winter MC, Tidy JA, Palmer JE, Sarwar N, Singh K, Aguiar X, Hancock BW, Pacey AA, Seckl MJ, Harrison RF.Gynecol Oncol. 2024 Jan;180:152-159. doi: 10.1016/j.ygyno.2023.11.017. Epub 2023 Dec 12.PMID: 38091775

  1. From National to International Collaboration in Gestational Trophoblastic Disease: Hurdles and Possibilities. Golfier F, Seckl MJ.Gynecol Obstet Invest. 2024;89(3):254-258. doi: 10.1159/000534321. Epub 2023 Oct 12.PMID: 37827125

  2. Immunotherapy for Gestational Trophoblastic Neoplasia: A New Paradigm. Baas IO, Westermann AM, You B, Bolze PA, Seckl M, Ghorani E.Gynecol Obstet Invest. 2024;89(3):230-238. doi: 10.1159/000533972. Epub 2023 Sep 13.PMID: 37703867

  3. 4 -

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

  1. Adapting the design of the ongoing RAMPART trial in response to external evidence: An example for trials which take many years to run and report.

Meade A, Frangou E, Choodari-Oskooei B, Larkin J, Powles T, Stewart GD, Albiges L, Bex A, Choueiri TK, Davis ID, Eisen T, Fielding A, Gedye C, Harrison DJ, Kaplan R, Mulhere S, Nathan P, Patel G, Patel J, Plant H, Ritchie A, Rush H, Shakeshaft C, Stockler MR, Suarez C, Thompson J, Thorogood N, Venugopal B, Parmar MKB. Contemp Clin Trials Commun. 2024 Oct 18;42

  1. Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses from the JAVELIN Renal 101 trial. Tucker M, Chen YW, Voss MH, McGregor BA, Bilen MA, Grimm MO, Nathan P, Kollmannsberger C, Tomita Y, Huang B, Amezquita R, Mariani M, di Pietro A, Rini B BMJ Oncol. 2024 Jun 12;3(1)

  2. Temporary treatment cessation compared with continuation of tyrosine kinase inhibitors for adults with renal cancer: the STAR non-inferiority RCT.

Collinson F, Royle KL, Swain J, Ralph C, Maraveyas A, Eisen T, Nathan P, Jones R, Meads D, Min Wah T, Martin A, Bestall J, Kelly-Morland C, Linsley C, Oughton J, Chan K, Theodoulou E, Arias-Pinilla G, Kwan A, Daverede L, Handforth C, Trainor S, Salawu A, McCabe C, Goh V, Buckley D, Hewison J, Gregory W, Selby P, Brown J, Brown J; all the STAR investigators. Health Technol Assess 2024 Aug;28(45):1-171

  1. Real-world Treatment Sequencing and Outcomes With Cabozantinib After First-line Immune Checkpoint Inhibitor-based Combination Therapy For Patients With Advanced Renal Cell Carcinoma: CARINA Study Results. Nathan P, Venugopal B, Ali J, Allison J, Ceruso M, Charnley N, Griffiths R, Michael A, Moore K, Perrot V, Prendergast Á, Sharma A, Szabados B, Larkin J. Clin Genitourin Cancer. 2024 Oct;22(5):102141.

  2. Tebentafusp Induces a T-Cell-Driven Rash in Melanocyte-Bearing Skin as an Adverse Event Consistent with the Mechanism of Action

Hassel JC, Stanhope S, Greenshields-Watson A, Machiraju D, Enk A, Holland C, Abdullah SE, Benlahrech A, Orloff M, Nathan P, Piperno-Neumann S, Staeger R, Dummer R, Meier-Schiesser B. J Invest Dermatol. 2024 Jul 15:S0022-202X(24)01886-4.

  1. Long-term survival follow-up for tebentafusp in previously treated metastatic uveal melanoma. Sacco JJ, Carvajal RD, Butler MO, Shoushtari AN, Hassel JC, Ikeguchi A, Hernandez-Aya L, Nathan P, Hamid O, Piulats JM, Rioth M, Johnson DB, Luke JJ, Espinosa E, Leyvraz S, Collins L, Holland C, Sato T.J. Immunother Cancer. 2024 Jun 6;12(6)

  2. A three-arm randomised phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma.

Sacco JJ, Jackson R, Corrie P, Danson S, Evans TRJ, Ochsenreither S, Kumar S, Goodman A, Larkin J, Karydis I, Steven N, Lorigan P, Plummer R, Patel P, Psarelli E, Olsson-Brown A, Shaw H, Leyvraz S, Handley L, Rawcliffe C, Nathan P. Eur J Cancer. 2024 May;202:114009

  1. Nilotinib in KIT-driven advanced melanoma: Results from the phase II single-arm NICAM trial. Larkin J, Marais R, Porta N, Gonzalez de Castro D, Parsons L, Messiou C, Stamp G, Thompson L, Edmonds K, Sarker S, Banerji J, Lorigan P, Evans TRJ, Corrie P, Marshall E, Middleton MR, Nathan P, Nicholson S, Ottensmeier C, Plummer R, Bliss J, Valpione S, Turajlic S. Cell Rep Med. 2024 Feb 16:101435. doi: 10.1016/ j.xcrm.2024.101435. Online ahead of print.

  2. Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma. Björk JR, Bolte LA, Maltez Thomas A, Lee KA, Rossi N, Wind TT, Smit LM, Armanini F, Asnicar F, Blanco-Miguez A, Board R, Calbet-Llopart N, Derosa L, Dhomen N, Brooks K, Harland M, Harries M, Lorigan P, Manghi P, Marais R, Newton-Bishop J, Nezi L, Pinto F, Potrony M, Puig S, Serra-Bellver P, Shaw HM, Tamburini S, Valpione S, Waldron L, Zitvogel L, Zolfo M, de Vries EGE, Nathan P, Fehrmann RSN, Spector TD, Bataille V, Segata N, Hospers GAP, Weersma RK. Nat Med. 2024 Feb 16. doi: 10.1038/s41591-024-02803-3. Online ahead of print.

  3. 5 -

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

  1. Evaluation of prognostic scores in patients with HCC undergoing first-line immunotherapy with atezolizumab and bevacizumab.

Gairing SJ, Mildenberger P, Gile J, Artusa F, Scheiner B, Leyh C, Lieb S, Sinner F, Jörg V, Fruendt T, Himmelsbach V, Abedin N, Sahin C, Böttcher K, Schuhbaur J, Labuhn S, Korolewicz J, Fulgenzi CAM, D'Alessio A, Zanuso V, Hucke F, Röhlen N, Ben Khaled N, Ramadori E, Müller L, Weinmann A, Kloeckner R, Galle PR, Tran NH, Venkatesh SK, Teufel A, Ebert M, De Toni EN, Waldschmidt DT, Marquardt JU, Bettinger D, Peck-Radosavljevic M, Geier A, Reiter FP, Rimassa L, Pinato DJ, Roderburg C, Ettrich T, Bitzer M, Scheble V, Ehmer U, Berres ML, Finkelmeier F, Gonzalez-Carmona MA, von Felden J, Schulze K, Venerito M, van Bömmel F, Jochheim LS, Pinter M, Mohr R, Ilyas SI, Schmidtmann I, Foerster F. JHEP Rep. 2024 Dec 5;7(3):101295. doi: 10.1016/j.jhepr.2024.101295. PMID: 40059970; PMCID: PMC11889551.

  1. Glucagon-like peptide-1 receptor agonist use is associated with a lower risk of major adverse liver-related outcomes: a meta-analysis of observational cohort studies. Celsa C, Pennisi G, Tulone A, Ciancimino G, Vaccaro M, Infantino G, Di Maria G, Pinato DJ, Cabibbo G, Enea M, Mantovani A, Tilg H, Targher G, Cammà C, Petta S. Gut. 2025 Apr 7;74(5):815-824. doi: 10.1136/ gutjnl-2024-334591. PMID:40015951.

  2. Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors. Luke JJ, Pinato DJ, Juric D, LoRusso P, Hosein PJ, Desai AM, Haddad R, de Miguel M, Cervantes A, Kim WS, Marabelle A, Zhang Y, Rong Y, Yuan X, Champiat S. J Immunother Cancer. 2025 Feb 20;13(2):e010511. doi:10.1136/jitc-2024-010511. PMID: 39979069; PMCID: PMC11842995.

  3. UK cancer vaccine advance - Recognising and realising opportunities. Craddock C, Earwaker P, Fittall M, Fontana E, Ganesh D, Gerlinger M, Ghafoor Q, Jones RP, Kunene V, Lee L, Lee R, Lee SM, Linch M, Little M, Liu J, McKenzie H, Petty R, Pinato DJ, Powles T, Protheroe A, Robinson T, Ross PJ, Shiu KK, Spicer J, Symeonides S, Tilby M, Vimalachandran D, Wang JY, Wardley A, Winter H. Camb Prism Precis Med. 2025 Jan 20;3:e1. doi: 10.1017/pcm.2024.5. PMID: 39944656; PMCID:PMC11811843.

  4. Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry.

Cortellini A, Brunetti L, Di Fazio GR, Garbo E, Pinato DJ, Naidoo J, Katz A, Loza M, Neal JW, Genova C, Gettinger S, Kim SY, Jayakrishnan R, El Zarif T, Russano M, Pecci F, Di Federico A, Awad M, Alessi JV, Montrone M, Owen DH, Signorelli D, Fidler MJ, Li M, Camerini A, De Giglio A, Young L, Vincenzi B, Metro G, Passiglia F, Yendamuri S, Guida A, Ghidini M, Awosika NO, Napolitano A, Fulgenzi CAM, Grisanti S, Grossi F, D'Incecco A, Josephides E, Van Hemelrijck M, Russo A, Gelibter A, Spinelli G, Verrico M, Tomasik B, Giusti R, Newsom-Davis T, Bria E, Sebastian M, Rost M, Forster M, Mukherjee U, Landi L, Mazzoni F, Aujayeb A, Dupont M, Curioni-Fontecedro A, Chiari R, Pantano F, Morabito A, Leonetti A, Friedlaender A, Addeo A, Zoratto F, De Tursi M, Cantini L, Roca E, Mountzios G, Della Gravara L, Kalvapudi S, Inno A, Bironzo P, Di Marco Barros R, O'Reilly D, Bell J, Karapanagiotou E, Monnet I, Baena J, Macerelli M, Majem M, Agustoni F, Cortinovis DL, Tonini G, Minuti G, Bennati C, Mezquita L, Gorría T, Servetto A, Beninato T, Lo Russo G, Rogado J, Moliner L, Biello F, Aboubakar Nana F, Dingemans AM, Aerts JGJV, Ferrara R, Torri V, Hejleh TA, Takada K, Naqash AR, Garassino M, Peters S, Wakelee H, Nassar AH, Ricciuti B. J Immunother Cancer. 2025 Feb 4;13(2):e010674. doi:10.1136/jitc-2024-010674. PMID: 39904562; PMCID: PMC11795382.

  1. Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/ bevacizumab.

Wu M, Fulgenzi CAM, D'Alessio A, Cortellini A, Celsa C, Manfredi GF, Stefanini B, Wu YL, Huang YH, Saeed A, Pirozzi A, Pressiani T, Rimassa L, Schoenlein M, Schulze K, von Felden J, Mohamed Y, Kaseb AO, Vogel A, Roehlen N, Silletta M, Nishida N, Kudo M, Vivaldi C, Balcar L, Scheiner B, Pinter M, Singal AG, Glover J, Ulahannan S, Foerster F, Weinmann A, Galle PR, Parikh ND, Hsu WF, Parisi A, Chon HJ, Pinato DJ, Ang C. JHEP Rep. 2024 Oct 10;7(2):101232. doi: 10.1016/j.jhepr.2024.101232. PMID: 39877031; PMCID: PMC11773230.

  1. Clinical Outcomes With Immune Checkpoint Inhibitors in Patients With FGFR2/3, MTAP or ERBB2 Genomic Alterations in Advanced Urothelial Carcinoma.

Talukder R, Bakaloudi DR, Makrakis D, Diamantopoulos LN, Enright T, Leary JB, Raychaudhuri R, Tripathi N, Agarwal N, Jindal T, Brown JR, Zakharia Y, Rey-Cárdenas M, Castellano D, Nguyen CB, Alva A, Zakopoulou R, Bamias A, Barrera RM, Marmolejo D, Drakaki A, Pinato DJ, Korolewicz J, Buznego LA, Duran I, Carballeira CC, McKay RR, Stewart TF, Gupta S, Barata P, Yu EY, Koshkin VS, Khaki AR, Grivas P. Clin Genitourin Cancer. 2025 Feb;23(1):102284. doi:10.1016/j.clgc.2024.102284. Epub 2024 Dec 2. PMID: 39798390.

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

  1. Chronic Hepatitis C Infection Treated with Direct-Acting Antiviral Agents and Occurrence/Recurrence of Hepatocellular Carcinoma: Does It Still Matter?

Smirne C, Crobu MG, Landi I, Vercellino N, Apostolo D, Pinato DJ, Vincenzi F, Minisini R, Tonello S, D'Onghia D, Ottobrelli A, Martini S, Bracco C, Fenoglio LM, Campanini M, Berton AM, Ciancio A, Pirisi M. Viruses. 2024 Dec10;16(12):1899. doi: 10.3390/v16121899. PMID: 39772206; PMCID: PMC11680226.

  1. Immunotherapy Benefit Over Best Supportive Care in Hepatocellular Cancer With Child-Pugh B Dysfunction-Reply. Fulgenzi CAM, D'Alessio A, Pinato DJ. JAMA Oncol. 2025 Feb 1;11(2):188-189. doi: 10.1001/jamaoncol.2024.5819. PMID: 39724320.

  2. Deep Learning Model for Predicting Immunotherapy Response in Advanced Non-Small Cell Lung Cancer. Rakaee M, Tafavvoghi M, Ricciuti B, Alessi JV, Cortellini A, Citarella F, Nibid L, Perrone G, Adib E, Fulgenzi CAM, Hidalgo Filho CM, Di Federico A, Jabar F, Hashemi S, Houda I, Richardsen E, Rasmussen Busund LT, Donnem T, Bahce I, Pinato DJ, Helland Å, Sholl LM, Awad MM, Kwiatkowski DJ. JAMA Oncol. 2025 Feb 1;11(2):109-118. EPub: 2024 Dec 26. doi:10.1001/jamaoncol.2024.5356. PMID:39724105; PMCID: PMC11843371.

  3. Reply: Hepatic decompensation is the major driver of mortality in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab: The impact of successful antiviral treatment. Celsa C, Cabibbo G, Pinato DJ. Hepatology. 2025 Mar 1;81(3):E103-E104. doi: 10.1097/HEP.0000000000001217. Epub 2024 Dec 25. PMID: 39724005.

  4. Single-cell RNA sequencing-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma.

Cappuyns S, Piqué-Gili M, Esteban-Fabró R, Philips G, Balaseviciute U, Pinyol R, Gris-Oliver A, Vandecaveye V, Abril-Fornaguera J, Montironi C, Bassaganyas L, Peix J, Zeitlhoefler M, Mesropian A, Huguet-Pradell J, Haber PK, Figueiredo I, Ioannou G, Gonzalez-Kozlova E, D'Alessio A, Mohr R, Meyer T, Lachenmayer A, Marquardt JU, Reeves HL, Edeline J, Finkelmeier F, Trojan J, Galle PR, Foerster F, Mínguez B, Montal R, Gnjatic S, Pinato DJ, Heikenwalder M, Verslype C, Van Cutsem E, Lambrechts D, Villanueva A, Dekervel J, Llovet JM. J Hepatol. 2025 Jun;82(6):1036-1049. doi: 10.1016/j.jhep.2024.12.016. Epub 2024 Dec 19. PMID: 39709141; PMCID: PMC12086051.

  1. Immune checkpoint inhibitors and the liver: balancing therapeutic benefit and adverse events. De Martin E, Fulgenzi CAM, Celsa C, Laurent-Bellue A, Torkpour A, Lombardi P, D'Alessio A, Pinato DJ. Gut. 2025 Jun 6;74(7):1165-1177. doi:10.1136/gutjnl-2024-332125. PMID: 39658265.

  2. Outcome and management of patients with hepatocellular carcinoma who achieved a complete response to immunotherapy-based systemic therapy.

Scheiner B, Kang B, Balcar L, Radu IP, Reiter FP, Adžić G, Guo J, Gao X, Yuan X, Cheng L, Gorgulho J, Schultheiss M, Peeters F, Hucke F, Ben Khaled N, Piseddu I, Philipp A, Sinner F, D'Alessio A, Pomej K, Saborowski A, Bathon M, Schwacha-Eipper B, Zarka V, Lampichler K, Nishida N, Lee PC, Krall A, Saeed A, Himmelsbach V, Tesini G, Huang YH, Vivaldi C, Masi G, Vogel A, Schulze K, Trauner M, Djanani A, Stauber R, Kudo M, Parikh ND, Dufour JF, Prejac J, Geier A, Bengsch B, von Felden J, Venerito M, Weinmann A, Peck-Radosavljevic M, Finkelmeier F, Dekervel J, Ji F, Wang HW, Rimassa L, Pinato DJ, Bouattour M, Chon HJ, Pinter M. Hepatology. 2025 Jun 1;81(6):1714-1727. doi: 10.1097/HEP.0000000000001163. Epub 2024 Nov 21. PMID: 39643944.

  1. Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213).

Jin ZC, Zhou JW, Chen JJ, Ding R, Scheiner B, Wang SN, Li HL, Shen QX, Lu QY, Liu Y, Zhang WH, Luo B, Shi HB, Huang M, Wu YM, Yuan CW, Huang MS, Li JP, Wu JB, Zhu XL, Zhong BY, Zhou HF, Wang YQ, Gu SZ, Peng ZY, Zheng CS, Liu RB, Xu GH, Yang WZ, Xu AB, Liu DF, Qi X, Yeo YH, Zhu HD, Zhao Y, Pinato DJ, Ji F, Teng GJ. J Cachexia Sarcopenia Muscle. 2024 Dec;15(6):2705-2716. doi: 10.1002/jcsm.13615. Epub 2024 Nov 27. PMID: 39604073; PMCID: PMC11634469.

  1. Prior antibiotics, proton pump inhibitors, and probiotics in patients with extensive stage small cell lung cancer treated with immune checkpoint blockade: A post-hoc analysis of the phase I/III IMpower 133 trial. Takada K, Takamori S, Shimokawa M, Pinato DJ, Cortellini A. Int J Cancer. 2025 Mar 1;156(5):914-919. doi: 10.1002/ijc.35249. Epub 2024 Nov 5. PMID: 39501485.

  2. 7 -

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

  1. New Scenarios in Liver Transplantation for Hepatocellular Carcinoma. Mauro E, Rodríguez-Perálvarez M, D'Alessio A, Crespo G, Piñero F, De Martin E, Colmenero J, Pinato DJ, Forner A. Liver Int. 2025 Apr;45(4):e16142. doi: 10.1111/liv.16142. Epub 2024 Nov 4. PMID: 39494583; PMCID: PMC11891387.

  2. Pathological response following neoadjuvant immune checkpoint inhibitors in patients with hepatocellular carcinoma: a cross-trial, patient-level analysis.

D'Alessio A, Stefanini B, Blanter J, Adegbite B, Crowley F, Yip V, Slater S, Fulgenzi CAM, Celsa C, Manfredi GF, Pai M, Goldin RD, Ward SC, Fiel MI, Shu DH, Su YY, Cortellini A, Baretti M, Anders R, Yarchoan M, Hsu C, Marron TU, Pinato DJ. Lancet Oncol. 2024 Nov;25(11):1465-1475. doi: 10.1016/S1470-2045(24)00457-1. Epub 2024 Oct 19. PMID: 39437804; PMCID: PMC12040480.

  1. Delivering adjuvant and neoadjuvant treatments in the early stages of hepatocellular carcinoma. Stefanini B, Manfredi GF, D'Alessio A, Fulgenzi CAM, Awosika N, Celsa C, Pirisi M, Rigamonti C, Burlone M, Vincenzi F, Minisini R, Gennari A, Yip V, Slater S, El-Shakankery K, Jain A, Tovoli F, Piscaglia F, Spalding D, Pai M, Pinato DJ. Expert Rev Gastroenterol Hepatol. 2024 Oct;18(10):647-660. doi: 10.1080/17474124.2024.2419519. Epub 2024 Oct 22. PMID: 39435480; PMCID: PMC11601036.

  2. Spatial single-cell profiling and neighbourhood analysis reveal the determinants of immune architecture connected to checkpoint inhibitor therapy outcome in hepatocellular carcinoma.

Salié H, Wischer L, D'Alessio A, Godbole I, Suo Y, Otto-Mora P, Beck J, Neumann O, Stenzinger A, Schirmacher P, Fulgenzi CAM, Blaumeiser A, Boerries M, Roehlen N, Schultheiß M, Hofmann M, Thimme R, Pinato DJ, Longerich T, Bengsch B. Gut. 2025 Feb 6;74(3):451-466. doi:10.1136/gutjnl-2024-332837. PMID: 39349005; PMCID: PMC11874287.

  1. Hepatic decompensation is the major driver of mortality in patients with HCC treated with atezolizumab plus bevacizumab: The impact of successful antiviral treatment. Celsa C, Cabibbo G, Fulgenzi CAM, Battaglia S, Enea M, Scheiner B, D'Alessio A, Manfredi GF, Stefanini B, Nishida N, Galle PR, Schulze K, Wege H, Ciccia R, Hsu WF, Vivaldi C, Wietharn B, Lin RP, Pirozzi A, Pressiani T, Dalbeni A, Natola LA, Auriemma A, Rigamonti C, Burlone M, Parisi A, Huang YH, Lee PC, Ang C, Marron TU, Pinter M, Cheon J, Phen S, Singal AG, Gampa A, Pillai A, Roehlen N, Thimme R, Vogel A, Soror N, Ulahannan S, Sharma R, Sacerdoti D, Pirisi M, Rimassa L, Lin CY, Saeed A, Masi G, Schönlein M, von Felden J, Kudo M, Cortellini A, Chon HJ, Cammà C, Pinato DJ. Hepatology. 2025 Mar 1;81(3):837-852. doi: 10.1097/HEP.0000000000001026. Epub 2024 Jul 19. PMID:39028886.

  2. Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade.

Mariniello A, Nasti TH, Chang DY, Hashimoto M, Malik S, McManus DT, Lee J, McGuire DJ, Cardenas MA, Umana P, Nicolini V, Antia R, Saha A, Buchwald Z, Kissick H, Ghorani E, Novello S, Sangiolo D, Scagliotti GV, Ramalingam SS, Ahmed R.

Clin Cancer Res. 2024 May 1;30(9):1833-1845. doi: 10.1158/1078-0432.CCR-23-1316. PMID: 37992307

  1. Axitinib after Treatment Failure with Sunitinib or Cytokines in Advanced Renal Cell Carcinoma-Systematic Literature Review of Clinical and Real-World Evidence.

Sharma A, Bahl A, Frazer R, Godhania E, Halfpenny N, Hartl K, Heldt D, McGrane J, Şahbaz Gülser S, Venugopal B, Ritchie A, Crichton K.Cancers (Basel). 2024 Jul 30;16(15):2706. doi: 10.3390/cancers16152706.PMID: 39123435

THE CANCER TREATMENT AND RESEARCH TRUST

TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

The trustees report was approved by the Board of Trustees.

D99F0000-7388-E6B6-E331-08DED13DDF68 .............................. Prof. Michael Seckl Trustees Date: ............................................. 25/06/2026

D99F0000-7388-E6B6-E33E-08DED13DDF68

THE CANCER TREATMENT AND RESEARCH TRUST

STATEMENT OF TRUSTEES RESPONSIBILITIES

FOR THE YEAR ENDED 31 DECEMBER 2024

The trustees are responsible for preparing the Trustees Report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

The law applicable to charities in England and Wales requires the trustees to prepare financial statements for each financial year which give a true and fair view of the state of affairs of the charity and of the incoming resources and application of resources of the charity for that year.

In preparing these financial statements, the trustees are required to:

The trustees are responsible for keeping sufficient accounting records that disclose with reasonable accuracy at any time the financial position of the charity and enable them to ensure that the financial statements comply with the Charities Act 2011, the Charity (Accounts and Reports) Regulations 2008 and the provisions of the trust deed. They are also responsible for safeguarding the assets of the charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

THE CANCER TREATMENT AND RESEARCH TRUST

INDEPENDENT EXAMINER'S REPORT

TO THE TRUSTEES OF THE CANCER TREATMENT AND RESEARCH TRUST

I report to the trustees on my examination of the financial statements of The Cancer Treatment and Research Trust (the charity) for the year ended 31 December 2024.

Responsibilities and basis of report

As the charity’s trustees you are responsible for the preparation of the accounts in accordance with the requirements of the Charities Act 2011 (‘the Act’).

I report in respect of my examination of the charity’s accounts carried out under section 145 of the Act and in carrying out my examination I have followed all the applicable Directions given by the Charity Commission under section 145(5)(b) of the Act.

Independent examiner's statement

Since the charity’s gross income exceeded £250,000 your examiner must be a member of a body listed in section 145 of the Act. I confirm that I am qualified to undertake the examination because I am a member of ACCA, which is one of the listed bodies.

I have completed my examination. I confirm that no matters have come to my attention in connection with the examination giving me cause to believe that in any material respect:

I have no concerns and have come across no other matters in connection with the examination to which attention should be drawn in this report in order to enable a proper understanding of the financial statements to be reached.

~~Adam~~ Shelley FCCA D99F0000-7388-E6B6-E34A-08DED13DDF68

Sobell Rhodes LLP

The Kinetic Centre Theobald Street Elstree Borehamwood Hertfordshire WD6 4PJ United Kingdom

Dated: ......................... 30/06/2026

D99F0000-7388-E6B6-E34E-08DED13DDF68

THE CANCER TREATMENT AND RESEARCH TRUST

STATEMENT OF FINANCIAL ACTIVITIES INCLUDING INCOME AND EXPENDITURE ACCOUNT

FOR THE YEAR ENDED 31 DECEMBER 2024

Unrestricted
Restricted
funds
funds
2024
2024
Notes
£
£
Income from:
Donation and legacies
2
384,379
100,182
Investment
3
17,590
-
Total income
401,969
100,182
Expenditure on:
Raising funds
4
5,108
-
Charitable activities
5
4,835
80,936
Support and
governance costs
8
51,323
-
Total expenditure
61,266
80,936
Net income/(expenditure)
340,703
19,246
Transfers between
funds
(36,447)
36,447
Net movement in
funds
304,256
55,693
Reconciliation of funds:
Fund balances at 1 January
2024
899,922
285,549
Fund balances at 31
December 2024
1,204,178
341,242		 Total
Unrestricted
Restricted
funds
funds
2024
2023
2023
£
£
£
(As
restated)
(As
restated)
484,561
105,189
62,348
17,590
12,201
-
502,151
117,390
62,348
5,108
5,708
-
85,771
46,386
128,546
51,323
42,403
-
142,202
94,496
128,546
359,949
22,894
(66,198)
-
190,248
(190,248)
359,949
213,142
(256,446)
1,185,471
686,780
541,995
1,545,420
899,922
285,549		 Total
2023
£
(As
restated)
167,537
12,201
179,738
5,708
174,932
42,403
223,043
(43,305)
-
(43,305)
1,228,775
1,185,471

The statement of financial activities includes all gains and losses recognised in the year. All income and expenditure derive from continuing activities.

THE CANCER TREATMENT AND RESEARCH TRUST

BALANCE SHEET

AS AT 31 DECEMBER 2024

Notes
Fixed assets
Intangible assets
10
Tangible assets
11
Investments
12
Current assets
Debtors
13
Cash at bank and in hand
Creditors: amounts falling due within
one year
14
Net current assets
Total assets less current liabilities
Net assets
The funds of the charity
Restricted income funds
16
Unrestricted funds		 2024
£
£
1,505
1,492
6,469
9,466
10,274
1,591,696
1,601,970
(66,018)
1,535,952
1,545,418
1,545,418
341,242
1,204,178
1,545,420		 2023
£
£
(As restated)
1,672
625
6,469
8,766
4,196
1,184,168
1,188,364
(11,661)
1,176,703
1,185,469
1,185,469
285,549
899,922
1,185,471		 2023
£
£
(As restated)
1,672
625
6,469
8,766
4,196
1,184,168
1,188,364
(11,661)
1,176,703
1,185,469
1,185,469
285,549
899,922
1,185,471
8,766
1,176,703
1,185,469
1,185,469
285,549
899,922
1,185,471

25/06/2026

The financial statements were approved by the trustees on .........................

D99F0000-7388-E6B6-E344-08DED13DDF68

.............................. D99F0000-7388-E6B6-E341-08DED13DDF68 Prof. Michael Seckl Trustees

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2024

1 Accounting policies

Charity information

The Cancer Treatment and Research Trust is a exists to support treatment and research into many forms of malignant disease and has been particularly involved in understanding how certain cancers develop, finding better ways to monitor them and developing new anti-cancer agents. It remains committed to funding research that is not adequately funded either by the major cancer charities such as CRUK, the MRC or the pharmaceutical industry.

1.1 Accounting convention

The financial statements have been prepared in accordance with the charity's governing document, the Charities Act 2011, FRS 102 “The Financial Reporting Standard applicable in the UK and Republic of Ireland” (“FRS 102”) and the Charities SORP "Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102)" (effective 1 January 2019). The charity is a Public Benefit Entity as defined by FRS 102.

The charity has taken advantage of the provisions in the SORP for charities not to prepare a Statement of Cash Flows.

The financial statements have departed from the Charities (Accounts and Reports) Regulations 2008 only to the extent required to provide a true and fair view. This departure has involved following the Statement of Recommended Practice for charities applying FRS 102 rather than the version of the Statement of Recommended Practice which is referred to in the Regulations but which has since been withdrawn.

The financial statements are prepared in sterling, which is the functional currency of the charity. Monetary amounts in these financial statements are rounded to the nearest £ 1.

The financial statements have been prepared under the historical cost convention. The principal accounting policies adopted are set out below.

1.2 Going concern

At the time of approving the financial statements, the trustees have a reasonable expectation that the charity has adequate resources to continue in operational existence for the foreseeable future. Thus the trustees continue to adopt the going concern basis of accounting in preparing the financial statements.

1.3 Income

All income is recognised in the Statement of Financial Activities once the charity has entitlement to the funds, it is probable that the income will be received and the amount can be measured reliably.

Donations and legacies are provided to the Charity, in order that the Charity can fulfil its purpose.

Legacies

Legacy income is recognised when receipt is probable, the amount can be measured reliably, and notification has been received from the personal representatives that the estate accounts have been finalised or that distributions can be reliably measured.

Grant income

Grant income that is subject to performance conditions is recognised when the charity has entitlement to the funds, it is probable that income will be received and any performance conditions have been met. Grants without performance conditions are recognised when the charity becomes unconditionally entitled to the income.

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

1 Accounting policies

(Continued)

Donated goods, Services and facilities

Where donated goods or services meet the recognition criteria of the SORP, the income is recognised at the fair value of the goods or services received. Where it is not practicable to reliably measure the value, the income is not recognised, but the nature of the donation is disclosed in the trustees’ report.

1.4 Expenditure

Liabilities are recognised as expenditure as soon as there is a legal or constructive obligation committing the charity to that expenditure, it is probable that a transfer of economic benefits will be required in settlement and the amount of the obligation can be measured reliably.

Expenditure is accounted for on an accruals basis and has been classified under headings that aggregate all cost related to the category. Where costs cannot be directly attributed to particular headings they have been allocated to activities on a basis consistent with the use of resources.

Governance and support costs

Support costs are those functions that assist the work of the charity but do not directly undertake charitable activities. These include administrative and financial management costs. Where support costs cannot be directly attributed, they are apportioned to activities based on an estimate of staff time or another suitable basis.

Governance costs are the costs associated with statutory compliance and oversight of the charity, including independent examination fees, accounts preparation costs and trustee meeting expenses.

Governance costs are presented as a separate component of expenditure in the Statement of Financial Activities.

1.5 Intangible fixed assets other than goodwill

Amortisation is recognised so as to write off the cost or valuation of assets less their residual values over their useful lives on the following bases:

Website 10% on reducing balance

1.6 Tangible fixed assets

Depreciation is recognised so as to write off the cost or valuation of assets less their residual values over their useful lives on the following bases:

Plant and equipment 25% on reducing balance Computers 33% on reducing balance

1.7 Fixed asset investments

Investments are included at their fair value as at the balance sheet date. Quoted investments are valued at the mid-market price on the last working day of the financial year. Gains or losses arising on revaluation and disposals are recognised in the Statement of Financial Activities (SoFA) as Gains/(losses) on investments. Programme-related investments are measured at cost less impairment.

1.8 Cash and cash equivalents

Cash and cash equivalents include cash in hand, deposits held at call with banks, other short-term liquid investments with original maturities of three months or less, and bank overdrafts. Bank overdrafts are shown within borrowings in current liabilities.

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

1 Accounting policies

(Continued)

1.9 Financial instruments

The charity has elected to apply the provisions of Section 11 ‘Basic Financial Instruments’ and Section 12 ‘Other Financial Instruments Issues’ of FRS 102 to all of its financial instruments.

Financial instruments are recognised in the charity's balance sheet when the charity becomes party to the contractual provisions of the instrument.

Financial assets and liabilities are offset, with the net amounts presented in the financial statements, when there is a legally enforceable right to set off the recognised amounts and there is an intention to settle on a net basis or to realise the asset and settle the liability simultaneously.

Basic financial assets

Basic financial assets, which include debtors and cash and bank balances, are initially measured at transaction price including transaction costs and are subsequently carried at amortised cost using the effective interest method unless the arrangement constitutes a financing transaction, where the transaction is measured at the present value of the future receipts discounted at a market rate of interest. Financial assets classified as receivable within one year are not amortised.

Basic financial liabilities

Basic financial liabilities, including creditors and bank loans are initially recognised at transaction price unless the arrangement constitutes a financing transaction, where the debt instrument is measured at the present value of the future payments discounted at a market rate of interest. Financial liabilities classified as payable within one year are not amortised.

Trade creditors are obligations to pay for goods or services that have been acquired in the ordinary course of operations from suppliers. Amounts payable are classified as current liabilities if payment is due within one year or less. If not, they are presented as non-current liabilities. Trade creditors are recognised initially at transaction price and subsequently measured at amortised cost using the effective interest method.

1.10 Taxation

The charity is exempt from corporation tax on its charitable activities.

1.11 Employee benefits

The cost of any unused holiday entitlement is recognised in the period in which the employee’s services are received.

Termination benefits are recognised immediately as an expense when the charity is demonstrably committed to terminate the employment of an employee or to provide termination benefits.

1.12 Pension costs and other post-retirement benefits

Payments to defined contribution retirement benefit schemes are charged as an expense as they fall due.

1.13 Fund accounting

Unrestricted funds can be used in accordance with the charitable objectives at the discretion of the trustees.

Restricted funds can only be used for particular restricted purposes within the objects of the charity.

Restrictions arise when specified by the donor or when funds are raised for particular restricted purposes.

Further explanation of the nature and purpose of each fund is included in the notes to the financial statements.

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

2 Income from donation and legacies

Unrestricted Restricted Total Unrestricted Restricted Total
funds funds funds funds
2024 2024 2024 2023 2023 2023
£ £ £ £ £ £
Donations and gifts 384,379 100,182 484,561 105,189 62,348 167,537

3 Income from investments

Unrestricted Unrestricted
funds funds
2024 2023
£ £
Income from listed investments 646 345
Interest receivable 16,944 11,856
17,590 12,201

4 Expenditure on raising funds

Unrestricted Unrestricted
funds funds
2024 2023
£ £
Fundraising and publicity
Seeking donations, grants and legacies 5,108 5,708
Expenditure on charitable activities
UF
RF
Total		 Total
Charitable
Charitable
expenditure expenditure
2024 2024 2024 2023
£ £ £ £
Direct costs
Research expenses and lab fees 2,701 80,936 83,637 123,511
Research salaries - - - 31,608
Grants to Institutions - - - 12,993
Conference and Meeting 2,134 - 2,134 2,209
Event Expenses - - - 4,610
4,835 80,936 85,771 174,931

5 Expenditure on charitable activities

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

6 Trustees

During the year, £2,753 was reimbursed to two trustees in respect of travel and meeting expenses.

Research expenses totalling £248 were awarded to institutions where a trustee is employed. The trustee concerned did not participate in the approval of such work.

During the year, a gift with a value of £49 was presented to a trustee in recognition of service.

Donations of £12,464 gross of bank processing fees of £85 were received from two trustees.

No trustees received remuneration for their services.

7 Employees

The average monthly number of employees during the year was:

2024 2023
Number Number
2 1
Employment costs 2024 2023
£ £
Wages and salaries 25,751 14,000
Social security costs - 329
Other pension costs 328 233
26,079 14,562

There were no employees whose annual remuneration was more than £60,000.

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

8 Support and governance costs

Support and governance costs represent expenditure which is not directly attributable to a specific charitable activity but is necessary for the charity’s overall operations and statutory compliance.

Unrestricted Unrestricted
funds funds
2024 2023
£ £
Subscription 3,252 3,112
Travel and Subsistence 70 -
Wages 25,751 14,000
Staff recruitment 329 329
Pension 328 233
Insurance 691 574
Staff training - 275
Telephone 72 76
Postage and stationery 319 448
Advertising 361 1,526
Depreciation - computer expenses 1,905 882
Depreciation - plant and machinery 47 64
Computer equipment 692 217
Website 168 186
Sundries - 192
Bank charges 2,640 2,420
Entertainment 326
Accountancy fees 7,472 7,269
Governance costs 6,900 10,600
51,323 42,403

Governance costs include the cost of the independent examination and statutory accounts preparation.

Support costs represent the general administrative expenditure of the charity. These costs are allocated to an expenditure heading where the activity directly benefits from such expenditure; where allocation is not possible, the costs are shown within support costs.

9 Taxation

The charity is exempt from taxation on its activities because all its income is applied for charitable purposes.

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

10 Intangible fixed assets

Intangible fixed assets
Website
£
Cost
At 1 January 2024 and 31 December 2024 1,858
Amortisation and impairment
At 1 January 2024 186
Amortisation charged for the year 167
At 31 December 2024 353
Carrying amount
At 31 December 2024 1,505
At 31 December 2023 1,672

11 Tangible fixed assets

Tangible fixed assets
Plant and
equipment
Computers
£
£
Cost
At 1 January 2024
338
3,888
Additions
-
1,607
At 31 December 2024
338
5,495
Depreciation and impairment
At 1 January 2024
146
3,453
Depreciation charged in the year
48
692
At 31 December 2024
194
4,145
Carrying amount
At 31 December 2024
144
1,350
At 31 December 2023
139
488		 Total
£
4,226
1,607
5,833
3,599
740
4,339
1,494
627

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

12 Fixed asset investments

Listed
investments
£
Cost or valuation
At 1 January 2024 & 31 December 2024 6,469
Carrying amount
At 31 December 2024 6,469
At 31 December 2023 6,469

The trustees consider that the fair value of the charity’s listed investments is not materially different from cost; therefore, no gains or losses have been recognised during the year.

13 Debtors

Debtors
Amounts falling due within one year:
Trade debtors
Prepayments and accrued income		 2024
£
1,721
8,553
10,274		 2023
£
-
4,196
4,196

14 Creditors: amounts falling due within one year

Other taxation and social security
Trade creditors
Accruals and deferred income		 2024
£
80
28,667
37,271
66,018		 2023
£
38
135
11,488
11,661

15 Comparative information

Prior year comparatives have been restated to correct the allocation of certain income and expenditure between restricted and unrestricted funds. The original classification did not reflect the underlying restrictions attached to the funding. The effect of the restatement is to decrease restricted funds by £33,307 and increase unrestricted funds by the same amount, with corresponding adjustments to income/expenditure lines. There is no impact on total funds.

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

16 Restricted funds

The restricted funds of the charity comprise the unexpended balances of donations and grants held on trust subject to specific conditions by donors as to how they may be used.

At 1 January Incoming Resources Transfers At 31
2024 resources expended December
2024
£ £ £ £ £
1. Prostate Cancer Research
Project - 58,142 - - 58,142
2. Consultant PA’s
Gynaecological & Melanoma
Research - 24,489 (24,489) - -
3. Novel Agents Trials -1 38,201 - - - 38,201
4. Support of the Drug
Development at Hammersmith
Hospital - Immunotherapy 45,000 - - - 45,000
5. Novel Agents Trials -2 10,000 - - - 10,000
6. Research Fees Fellowship –
Immunotherapy 3,000 - - - 3,000
7. Support the Delivery of
Translational Studies in Cancer
– Immunotherapy - 10,000 - - 10,000
8. Uterus Research 25,000 - - - 25,000
9. CICATRIx & RaNGO
Administrator - 20,000 - - 20,000
10.PhD Studentship -
Investigating Intracellular
Checkpoints of T Cell Activity in
Cancer 130,000 - - - 130,000
11.RESOLVE Trial in
Gestational Trophoblastic
Neoplasia 30,000 - (248) - 29,752
12.Immunotherapy Trial GTD 4,348 12,827 - - 17,175
13.Laboratory Support for Lung
Cancer Research - - (18,691) 18,691 -
14. Melanoma Unit Research
Database Manager - - (17,756) 17,756 -
15. Melanoma Brain
Metastases Research Project - 5,000 - - 5,000

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

16 Restricted funds

Restricted funds
16.Tebentafusp EAP Study
Previous year:
At
(As restated)
Restricted fund		 -
14,212
-
285,549
100,182
(80,936)
1 January
2023
Incoming
resources
Resources
expended
£
£
£
541,995
62,348
(128,546)		 (Continued)
-
14,212
36,447
341,242
Transfers
At 31
December
2023
£
£
(190,248)
285,549

Fund transfers

During the year to 31 December 2024, expenditure was incurred on both lung cancer research and melanoma research specific projects which has been funded by the unrestricted fund.

During the year to 31 December 2023, expenditure was incurred on lung cancer research, RaNGO and Primm Studies research specific projects which has been funded by the unrestricted fund.

In addition, income previously ring-fenced as restricted has been identified and correctly reallocated as unrestricted income.

17 Unrestricted funds

The unrestricted funds of the charity comprise the unexpended balances of donations and grants which are not subject to specific conditions by donors and grantors as to how they may be used. These include designated funds which have been set aside out of unrestricted funds by the trustees for specific purposes.

Transfers between funds occur where restricted expenditure exceeds restricted income, or where the trustees have designated unrestricted funds to support restricted projects.

At
Unrestricted funds
Previous year:
At
(As restated)
Unrestricted funds		 1 January
2024
Incoming
resources
Resources
expended
£
£
£
899,922
401,969
(61,266)
1 January
2023
Incoming
resources
Resources
expended
£
£
£
686,780
117,390
(94,496)		 Transfers
At 31
December
2024
£
£
(36,447)
1,204,178
Transfers
At 31
December
2023
£
£
190,248
899,922

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

18 Analysis of net assets between funds

Unrestricted
Restricted
funds
funds
2024
2024
£
£
At 31 December 2024:
Intangible fixed assets
1,505
-
Tangible assets
1,494
-
Investments
6,469
-
Current assets/(liabilities)
1,194,710
341,242
1,204,178
341,242
Unrestricted
Restricted
funds
funds
2023
2023
£
£
At 31 December 2023:
Intangible fixed assets
1,672
-
Tangible assets
627
-
Investments
6,469
-
Current assets/(liabilities)
891,154
285,549
899,922
285,549		 Total
2024
£
1,505
1,494
6,469
1,535,952
1,545,420
Total
2023
£
1,672
627
6,469
1,176,703
1,185,471

19 Capital commitments

At the reporting date, the charity had the following capital commitments:

Contracted but not provided for: £2,520 (previous year: £ Nil)

This represents the amounts that the company is contractually obligated to pay for capital expenditure that has not yet been accounted for in these financial statements.

THE CANCER TREATMENT AND RESEARCH TRUST

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2024

20 Events after the reporting date

Subsequent to the year end, the charity was informed that it is entitled to receive a further distribution from the estate of Mrs G, from which a legacy of £300,000 had been received and recognised during the year ended 31 December 2024.

Whilst the charity was aware at the balance sheet date that a further amount may be receivable once the administration of the estate had been finalised, the value of the additional distribution was uncertain at that date and could not be estimated reliably. The amount expected to be received was subsequently confirmed by the executors in October 2025 as approximately £70,000.

A further payment of £43,996 was received from the estate in December 2025, with an additional balance expected to be received upon completion of probate and finalisation of the estate administration.

As the conditions giving rise to the additional entitlement were not sufficiently certain at 31 December 2024, no adjustment has been made to these financial statements in respect of the further legacy income.

21 Related party transactions

The charity is required to disclose material related party transactions under the Charities SORP (FRS 102).

During the year:

No other related party transactions require disclosure.

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