Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
Charity registration number :1194608
Company registration number CE025306 (England and Wales)
THE CANCER TREATMENT AND RESEARCH TRUST CIO ANNUAL REPORT AND UNAUDITED FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
CONTENTS
| Page | |
|---|---|
| Trustees report | 1 - 10 |
| Independent examiner's report | 11 |
| Statement of financial activities | 12 |
| Balance sheet | 13 - 14 |
| Notes to the financial statements | 15 - 22 |
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT
FOR THE YEAR ENDED 31 DECEMBER 2023
The trustees have adopted the provisions of Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).
STRUCTURE, GOVERNANCE, MANAGEMENT
The history of the charity goes back to 1985. The charity supports work mainly in the departments of medical oncology at the West London Cancer Centre based at Charing Cross and Hammersmith Hospitals (Imperial College Healthcare NHS Trust) and in the department of medical oncology at the Mount Vernon Cancer Centre, in Northwood, Middlesex. The charity has been controlled by its governing document, a deed of trust and constitutes an unincorporated charity.
Trustees
The CTRT Board of Trustees is made up of 10 professionals with legal or medical backgrounds as regulated by the deed of trust in line with the Charity Commission regulations. Cancer physicians dominate, in line with the aims of the charity.
Administration
On 1st January 2022, CTRT officially transitioned to a Charitable Incorporated Organisation (CIO) status. The original Cancer Treatment and Research Trust (charity number 292909) remains registered as a charity with the Charity Commission, albeit it only remains active in order to manage any residual matters following the 2022 transition.
OBJECTIVES AND ACTIVITIES
The Cancer Treatment and Research Trust (CTRT) which was founded in 1985, supports work mainly in the departments of medical oncology at the West London Cancer Centre based at Charing Cross Hospital and in the department of medical oncology at the Mount Vernon Cancer Centre, in Northwood, Middlesex. The CTRT exists to support treatment and research into many forms of malignant disease and has been particularly involved in understanding how certain cancers develop, finding better ways to monitor them and developing new anti-cancer agents. It remains committed to funding research that is not adequately funded either by the major cancer charities such as CRUK, the MRC or the pharmaceutical industry.
ACHIEVEMENT AND PERFORMANCE
The trustees are pleased with the achievements and performance of the Trust in 2023. In 2023, research, either fully or partly funded by CTRT, led to 84 publications.
The research supported by CTRT can be roughly split into the following areas:
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Ovarian, uterine and rare gynaecological cancers
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Lung Cancer
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Testicular and Ovarian Germ Cell Cancer
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Gestational Trophoblastic Disease
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Melanoma
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Renal Cancer
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Immunotherapy/Immunology
Details about the research, together with the relevant publications and studies, are available on the Trust’s website - cancertreatment.org.uk
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
Financial review
The financial results for the year are as shown in the financial section of this report and cover accounting period of 12 months from 01 January 2023 to 31st December 2023. The carry forward funds as at 31st December 2023 amounted to £1,185,469, of which was £899,920 was unrestricted and £285,549 was restricted.
PLANS FOR THE FUTURE
Investing in fundraising:
CTRT have agreed to recruit a second part time staff member who will have responsibility for communications and marketing of the charity with the aim of increasing the charity’s supporter base.
Plans for research:
CTRT will continue to support a diverse variety of research into many cancers including several different types of less common cancers such as ovarian, uterine, melanoma and also very rare cancers such as gestational trophoblast disease, germ cell tumours and rare gynaecological cancers. Our research supports clinical studies as well as laboratory focused work such as developing novel biomarkers. Immunotherapy continues to be a major area of interest in the cancer world and CTRT supports research studying the effects of immunotherapy in trophoblastic, lung and renal cancers.
Details of previous research and further details about existing projects can be found on the website.
RISK MANAGEMENT
The Trustees are aware of the risks affecting the Trust and its work and have ensured that policies are in place to mitigate the effect of these risks.
Financial risks and Investment
A key aim of the Board is to ensure CTRT holds adequate reserves for working capital purposes and has sufficient funds to meet contractual liabilities and winding down costs, if the organisation were to close. This includes redundancy pay, amounts due to creditors and commitments under contracts. CTRT’s level of reserves also helps the organisation to plan expenditure against variations in the way funding is received. To balance the uncertainty of funding, our policy is to maintain financial reserves to cover these costs and allow for an orderly wind down. The current estimate of these costs is c £20,000 - £30,000. Without current level of support from our individual donors and based on current expenditure levels, CTRT is estimated to still remain in a position to cover these costs for the coming 12 months as our unrestricted reserve stand at about £899,920 .
Governance structure:
The review of governance structure, policies and procedures was commenced and following that review, any recommendations made and agreed upon by the trustees will be implemented in the authorised order.
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
Reserves policy
Sufficient reserves are maintained to ensure that all expenses, as well as future research costs, are covered in the event no donations are received in any one year.
For many years the CTRT received funds to pay for research staff running clinical trials from pharmaceutical companies and trial organisations. Increasingly these funds have been paid directly to support the local NHS Trusts who employ these staff. As of 1st January 2008 the accounts related to Mount Vernon Cancer Centre only include income and expenses actually paid into or out of CTRT accounts.
CONCLUSION
Research, either totally or partly funded by CTRT led to 84 publications in 2023.
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Adjuvant Nivolumab Versus Ipilimumab in Resected Stage III/IV Melanoma: 5-Year Efficacy and Biomarker Results From CheckMate 238. Larkin J, Del Vecchio M, Mandala M, Gogas H, Arance AM, Dalle S, Cowey CL, Schenker M, Grob JJ, Chiarion-Sileni V, Marquez-Rodas I, Butler MO, Di Giacomo AM, Middleton MR, Lutzky J, de la Cruz-Merino L, Arenberger P, Atkinson V, Hill AG, Fecher LA, Millward M, Nathan PD , Khushalani NI, Queirolo P, Ritchings C, Lobo M, Askelson M, Tang H, Dolfi S, Ascierto PA, Weber J. Clin Cancer Res. 2023 Apr 14:CCR-22-3145.
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AN0025, a novel antagonist of PGE2-receptor E-type 4 (EP4), in combination with total neoadjuvant treatment of advanced rectal cancer. Wyrwicz L, Saunders M, Hall M, Ng J, Hong T, Xu S, Lucas J, Lu X, Lautermilch N, Formenti S, Glynne-Jones R. Radiother Oncol. 2023 Aug;185:109669. doi: 10.1016/ j.radonc.2023.109669. Epub 2023 Apr 11. PMID: 37054987.
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A Novel Radiogenomics Biomarker for Predicting Treatment Response and Pneumotoxicity From Programmed Cell Death Protein or Ligand-1 Inhibition Immunotherapy in NSCLC. Chen M, Lu H, Copley SJ, Han Y, Logan A, Viola P, et al. J Thorac Oncol. 2023;18(6):718-30.
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Antibiotic Therapy: The Cornerstone of Iatrogenic Resistance to Immune Checkpoint Inhibitors. Pinato DJ , Cortellini A. J Clin Oncol. 2023;41(17):3089-91.
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Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab-bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study. Zeng Q, Klein C, Caruso S, Maille P, Allende DS, Mínguez B, et al. Lancet Oncol. 2023;24(12):1411-22.
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Association between antibiotics and adverse oncological outcomes in patients receiving targeted or immune-based therapy for hepatocellular carcinoma. Pinato DJ , Li X, Mishra-Kalyani P, D'Alessio A, Fulgenzi CAM, Scheiner B, et al. JHEP Rep. 2023;5(6):100747.
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Association of a Mediterranean Diet With Outcomes for Patients Treated With Immune Checkpoint Blockade for Advanced Melanoma. Bolte LA, Lee KA, Björk JR, Leeming ER, Campmans-Kuijpers MJE, de Haan JJ, Vila AV, Maltez-Thomas A, Segata N, Board R, Harries M, Lorigan P, de Vries EGE, Nathan P , Fehrmann R, Bataille V, Spector TD, Hospers GAP, Weersma RK. JAMA Oncol. 2023 Feb 16:e227753. doi: 10.1001/jamaoncol.2022.7753. Online ahead of print. PMID: 36795408.
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Association of Machine Learning-Based Assessment of Tumor-Infiltrating Lymphocytes on Standard Histologic Images With Outcomes of Immunotherapy in Patients With NSCLC. Rakaee M, Adib E, Ricciuti B, Sholl LM, Shi W, Alessi JV, et al. JAMA Oncol. 2023;9(1):51-60.
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Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma. Dharmapuri S, Özbek U, Jethra H, Jun T, Marron TU, Saeed A, et al. World J Gastrointest Oncol. 2023;15(11):1900-12.
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Characterization of Age-Associated, Neutrophil-to-Lymphocyte Ratio (NLR) and Systemic ImmuneInflammatory Index (SII) as Biomarkers of Inflammation in Geriatric Patients with Cancer Treated with Immune Checkpoint Inhibitors: Impact on Efficacy and Survival. Choucair K, Nebhan C, Cortellini A, Hentzen S, Wang Y, Liu C, et al. Cancers (Basel). 2023;15(20).
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
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Clinical Utility of Albumin Bilirubin Grade as a Prognostic Marker in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: a Systematic Review and Meta-analysis. Mishra G, Majeed A, Dev A, Eslick GD, Pinato DJ , Izumoto H, et al. J Gastrointest Cancer. 2023;54(2):420-32.
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Clinicopathologic and Genomic Factors Impacting Efficacy of First-Line Chemoimmunotherapy in Advanced NSCLC. Alessi JV, Elkrief A, Ricciuti B, Wang X, Cortellini A, Vaz VR, et al. J Thorac Oncol. 2023;18(6):731-43.
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Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer. van de Haar J, Ma X, Ooft SN, van der Helm PW, Hoes LR, Mainardi S, et al. Nat Med. 2023;29(3):605-14.
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Combined chemotherapy and pembrolizumab salvages multi-chemotherapy agent and avelumab resistant choriocarcinoma: A case report. Lehmann M, Hosa H, Bartl T, Tsibulak I, Polterauer S, Pötsch N, Seckl MJ , Marth C.Gynecol Oncol Rep. 2023 Aug 12;49:101259. doi: 10.1016/j.gore.2023.101259. eCollection 2023 Oct.PMID: 37636493 Free PMC article.
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Consensus report from the 10th Global Forum for Liver Magnetic Resonance Imaging: developments in HCC management. Taouli B, Ba-Ssalamah A, Chapiro J, Chhatwal J, Fowler K, Kang TW, et al. Eur Radiol. 2023;33(12):9152-66.
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Consensus report from the 10th Global Forum for Liver Magnetic Resonance Imaging: multidisciplinary team discussion. Taouli B, Ba-Ssalamah A, Chapiro J, Chhatwal J, Fowler K, Kang TW, et al. Eur Radiol. 2023;33(12):9167-81.
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Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells. Chrisochoidou Y, Roy R, Farahmand P, Gonzalez G, Doig J, Krasny L, Rimmer EF, Willis AE, MacFarlane M, Huang PH, Carragher NO, Munro AF, Murphy DJ, Veselkov K, Seckl MJ , Moffatt MF, Cookson WOC, Pardo OE.Cell Death Dis. 2023 Nov 8;14(11):725. doi: 10.1038/s41419-023-06240-x.PMID: 37938546 Free PMC article.
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Description of a Retrospective Cohort of Epithelial Ovarian Cancer Patients with Brain Metastases: Evaluation of the Role of PARP Inhibitors in this Setting. Alizzi Z, Roxburgh P, Cartwright D, McLaren A, Park S, Jones R, Greening S, Hudson E, Green C, Gray S, Khalique S, Karteris E, Hall M . J Clin Med. 2023 Mar 25;12(7):2497. doi: 10.3390/jcm12072497. PMID: 37048581; PMCID: PMC10095324.
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Development of a dual energy CT based model to assess response to treatment in patients with high grade serous ovarian cancer: a pilot cohort study. Alizzi Z, Gogbashian A, Karteris E, Hall M . Cancer Imaging. 2023 Jun 15;23(1):62. doi: 10.1186/s40644-023-00579-2. PMID: 37322564; PMCID: PMC10268407.
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Diabetes and Immune Checkpoint Inhibitors-Response. Cortellini A, D'Alessio A, Pinato DJ . Clin Cancer Res. 2023;29(19):4017-8.
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Disturbances in sodium and chloride homeostasis predict outcome in stable and critically ill patients with cirrhosis. Semmler G, Scheiner B, Balcar L, Paternostro R, Simbrunner B, Pinter M, et al. Aliment Pharmacol Ther. 2023;58(1):71-9.
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EADO, EDF, ESTRO, UEMS and EADV European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, GaudyMarqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P , Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; Eur J Cancer. 2023 Jul 28;192:113254.
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Editorial: Fertility-preserving and Fertility-sparing treatment approaches in gynecologic malignancies. Raimondo D, Raffone A, Neola D, Vizzielli G, Caserta D, Hall M , Casadio P, Seracchioli R, Driul L, Restaino S. Front Oncol. 2023 Jun 2;13:1199582. doi: 10.3389/fonc.2023.1199582. PMID: 37333826; PMCID:PMC10272815.
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
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Efficacy analysis of single-agent carboplatin AUC4 2-weekly as second-line therapy for methotrexateresistant (MTX-R) low risk gestational trophoblastic neoplasia (GTN). Winter MC, Tidy JA, Singh K, Sarwar N, Aguiar X, Seckl MJ . Gynecol Oncol. 2023 Aug;175:66-71. doi: 10.1016/j.ygyno.2023.05.072. Epub 2023 Jun 14.PMID: 37327541.
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Efficacy and safety of atezolizumab/bevacizumab in patients with HCC after prior systemic therapy: A global, observational study. Joerg V, Scheiner B, A DA, Fulgenzi CAM, Schönlein M, Kocheise L, et al. Hepatol Commun. 2023;7(11).
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Efficacy and safety of frontline systemic therapy for advanced HCC: A network meta-analysis of landmark phase III trials. Fulgenzi CAM, Scheiner B, Korolewicz J, Stikas CV, Gennari A, Vincenzi B, et al. JHEP Rep. 2023;5(5):100702.
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Efficacy and safety of immune checkpoint inhibitor rechallenge in individuals with hepatocellular carcinoma. Scheiner B, Roessler D, Phen S, Lim M, Pomej K, Pressiani T, et al. JHEP Rep. 2023;5(1):100620.
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Epithelioid trophoblastic tumor with antecedent molar pregnancy in an HIV-positive patient. Black L, Bowes A, Seckl M , Maher G, Kaur B, Arumainayagam J, Acharya S. Clin Case Rep. 2023 Mar 27;11(3):e7114. doi: 10.1002/ccr3.7114. eCollection 2023 Mar.PMID: 36998325 Free PMC article.
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European multidisciplinary tumor boards support cross-border networking and increase treatment options for patients with rare gynecological tumors. Joneborg U, Bergamini A, Wallin E, Mangili G, Solheim O, Marquina G, Casado A, Rokkones E, Coulter J, Lok CAR, van Trommel N, Amant F, Bolze PA, Sehouli J, Han S, Kridelka F, Goffin F, Pautier P, Ray-Coquard I, Seckl M . Int J Gynecol Cancer. 2023 Oct 2;33(10):1621-1626. doi: 10.1136/ijgc-2023-004599.PMID: 37783481 Free PMC article.
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Fertility outcomes following surgery and multiagent chemotherapy in malignant ovarian germ cell tumor survivors: a survey study. Bergamini A, Ramaswami R, Froeling F, Papanastasopoulos P, Short D, Aguiar X, Savage PM, Sarwar N, Kaur B, Saso S, Fotopoulou C, Sharma A , Rustin GJS , Seckl M . Int J Gynecol Cancer. 2023 Nov 6;33(11):1750-1756. doi: 10.1136/ijgc-2023-004699.PMID: 37931975.
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From National to International Collaboration in Gestational Trophoblastic Disease: Hurdles and Possibilities. Golfier F, Seckl MJ . Gynecol Obstet Invest. 2024;89(3):254-258. doi: 10.1159/000534321. Epub 2023 Oct 12.PMID: 37827125 Free PMC article.
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Future Directions for Gestational Trophoblastic Disease. Ghorani E , Seckl MJ . Hematol Oncol Clin North Am. 2024 Sep 24:S0889-8588(24)00115-1. doi: 10.1016/j.hoc.2024.08.019. Online ahead of print. PMID: 39322464 Review.
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Germ cell cancer in pregnancy – Successfully treated with chemotherapy and surgery. A. Sharma , I. Reid, A. Gogbashian, B. Kaur, C. Fotopoulou. Gynaecologic Oncology Reports, Volume 47, 2023.
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Identification of RAD51 foci in cancer-associated circulating cells of patients with high-grade serous ovarian cancer: association with treatment outcomes. Alizzi Z, Saravi S, Khalique S, McDonald T, Karteris E, Hall M . Int J Gynecol Cancer. 2023 Sep 4;33(9):1427-1433. doi: 10.1136/ijgc-2023-004483. PMID: 37541687; PMCID: PMC10511972.
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Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Xie E, Yeo YH, Scheiner B, Zhang Y, Hiraoka A, Tantai X, et al. JAMA Oncol. 2023;9(10):1423-31.
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Immune Checkpoint Inhibitors in hepatocellular carcinoma: emerging challenges in clinical practice. Pinter M, Scheiner B, Pinato DJ . Lancet Gastroenterol Hepatol. 2023;8(8):760-70.
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Immunotherapy for Gestational Trophoblastic Neoplasia: A New Paradigm. Baas IO, Westermann AM, You B, Bolze PA, Seckl M , Ghorani E . Gynecol Obstet Invest. 2024;89(3):230-238. doi: 10.1159/000533972. Epub 2023 Sep 13.PMID: 37703867 Free PMC article.
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
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Immunotherapy in hepatocellular carcinoma: how will it reshape treatment sequencing? Cammarota A, Zanuso V, Manfredi GF, Murphy R, Pinato DJ , Rimassa L. Ther Adv Med Oncol. 2023;15:17588359221148029.
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Immunotherapy-related adverse events in real-world patients with advanced non-small cell lung cancer on chemoimmunotherapy: a Spinnaker study sub-analysis. Anpalakhan S, Huddar P, Behrouzi R, Signori A, Cave J, Comins C, et al. Front Oncol. 2023;13:1163768.
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Impact of body mass index in patients receiving atezolizumab plus bevacizumab for hepatocellular carcinoma. Vithayathil M, D'Alessio A, Fulgenzi CAM, Nishida N, Schönlein M, von Felden J, et al.. Hepatol Int. 2023;17(4):904-14.
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Increased interleukin-6/C-reactive protein levels are associated with the upregulation of the adenosine pathway and serve as potential markers of therapeutic resistance to immune checkpoint inhibitor-based therapies in non-small cell lung cancer. Naqash AR, McCallen JD, Mi E, Iivanainen S, Marie MA, Gramenitskaya D, et al. J Immunother Cancer. 2023;11(10).
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Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma. Pinato DJ , Kaneko T, D'Alessio A, Forner A, Fessas P, Minguez B, et al. JHEP Rep. 2023;5(7):100741.
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Investigating the Regulation of Ribosomal Protein S6 Kinase 1 by CoAlation. Malanchuk O, Bdzhola A, Palchevskyi S, Bdzhola V, Chai P, Pardo OE, Seckl MJ , Banerjee A, Peak-Chew SY, Skehel M, Guruprasad L, Zhyvoloup A, Gout I, Filonenko V.Int J Mol Sci. 2024 Aug 11;25(16):8747. doi:10.3390/ijms25168747. PMID: 39201434 Free PMC article.
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Learning lessons from the COVID-19 pandemic for real-world evidence research in oncology-shared perspectives from international consortia. Castelo-Branco L, Lee R, Brandão M, Cortellini A, Freitas A, Garassino M, et al. ESMO Open. 2023;8(4):101596.
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Local and systemic therapy in liver cancer: the quest for synergy. Pinter M, Pinato DJ . Lancet Gastroenterol Hepatol. 2023;8(2):102-4.
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Long GV Neoadjuvant immunotherapy for melanoma is now ready for clinical practice. Garbe C, Dummer R, Amaral T, Amaria RN, Ascierto PA, Burton EM, Dreno B, Eggermont AMM, Hauschild A, Hoeller C, Kaufmann R, Lebbe C, Mandala M, Menzies AM, Moreno D, Michielin O, Nathan P , Patel SP, Robert C, Schadendorf D, Lorigan PC, Scolyer RA, Tawbi HA, van de Wiel BA, Blank C. Nat Med.2023 Jun;29(6):1310-1312. doi: 10.1038/s41591-023-02336-1.
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Measuring the Invisible: Circulating Tumor DNA as a Predictive and Prognostic Marker of Response to Adjuvant Chemotherapy in Resected Colorectal Cancer. D'Arienzo PD, Pinato DJ . Gastroenterology. 2023;165(5):1303-4.
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Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma. Manfredi GF, Celsa C, John C, Jones C, Acuti N, Scheiner B, et al. J Hepatocell Carcinoma. 2023;10:1955-71.
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Morphology combined with HER2 D-DISH ploidy analysis to diagnose partial hydatidiform mole: an evaluation audit using molecular genotyping. Joyce CM, Maher GJ, Dineen S, Suraweera N, McCarthy TV, Coulter J, O'Donoghue K, Seckl MJ , Fitzgerald B.J Clin Pathol. 2024 Aug 2:jcp-2023-209269. doi: 10.1136/ jcp-2023-209269. Online ahead of print. PMID: 38555105 Free article.
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NASH and Hepatocellular Carcinoma: Immunology and Immunotherapy. Pinter M, Pinato DJ , Ramadori P, Heikenwalder M Clin Cancer Res. 2023;29(3):513-20.
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Novel approaches to managing gestational trophoblastic tumors in the age of immunotherapy. Hennah L, Seckl M , Ghorani E . Int J Gynecol Cancer. 2023 Mar 6;33(3):414-419. doi: 10.1136/ijgc-2022003771.PMID: 36878565 Review.
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Outcomes of beta blocker use in advanced hepatocellular carcinoma treated with immune checkpoint inhibitors. Wu YL, van Hyfte G, Özbek U, Reincke M, Gampa A, Mohamed YI, et al. Front Oncol. 2023;13:1128
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
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Pandemic Phase-Adjusted Analysis of COVID-19 Outcomes Reveals Reduced Intrinsic Vulnerability and Substantial Vaccine Protection From Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Breast Cancer. Tagliamento M, Gennari A, Lambertini M, Salazar R, Harbeck N, Del Mastro L, et al. J Clin Oncol.2023;41(15):2800-14.
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Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept. Vitale A, Cabibbo G, Iavarone M, Viganò L, Pinato DJ , Ponziani FR, et al. Lancet Oncol. 2023;24(7):e312-e22.
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PETAL protocol: a phase Ib study of pembrolizumab after transarterial chemoembolization in hepatocellular carcinoma. Fessas P, Scheiner B, D'Alessio A, CA MF, Korolewicz J, Ward C, et al. Future Oncol. 2023;19(7):499-507.
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PREDICT-GTN 1: Can we improve the FIGO scoring system in gestational trophoblastic neoplasia? Parker VL, Winter MC, Tidy JA, Hancock BW, Palmer JE, Sarwar N, Kaur B, McDonald K, Aguiar X, Singh K, Unsworth N, Jabbar I, Pacey AA, Harrison RF, Seckl MJ . Int J Cancer. 2023 Mar 1;152(5):986-997. doi: 10.1002/ijc.34352. Epub 2022 Dec 3.PMID: 36346113 Free PMC article.
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PREDICT-GTN 2: Two-factor streamlined models match FIGO performance in gestational trophoblastic neoplasia. Parker VL, Winter MC, Tidy JA, Palmer JE, Sarwar N, Singh K, Aguiar X, Hancock BW, Pacey AA, Seckl MJ , Harrison RF. Gynecol Oncol. 2024 Jan;180:152-159. doi: 10.1016/j.ygyno.2023.11.017. Epub 2023 Dec 12.PMID: 38091775 Free article.
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Primary hepatic metastatic epitheloid trophoblastic tumor of the uterus treated with multimodal therapy including pembrolizumab and thermoablation. Case report of an extremely rare disease and review of the literature. Helbig M, Steinmann M, Jaschinski S, Seckl MJ , Meier W, Fehm T, Volkmer AK. Gynecol Oncol Rep. 2023 Sep 26;49:101281. doi: 10.1016/j.gore.2023.101281. eCollection 2023 Oct.PMID: 37822711 Free PMC article.
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Progression patterns and therapeutic sequencing following immune checkpoint inhibition for hepatocellular carcinoma: An international observational study. Talbot T, D'Alessio A, Pinter M, Balcar L, Scheiner B, Marron TU, et al. Liver Int. 2023;43(3):695-707.
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Recurrence and resistance risk factors in low-risk gestational trophoblastic neoplasia. Branco-Silva M, Maestá I, Horowitz N, Elias K, Seckl M , Berkowitz R. Int J Gynecol Cancer. 2024 Oct 7:ijgc-2024-005770. doi: 10.1136/ijgc-2024-005770. Online ahead of print. PMID: 39375166 Review.
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Recurrence of primitive germ cell tumour 20 years on. Younan HC, Keogh G, Seckl M , Sarwar N. BMJ Case Rep. 2023 Jan 4;16(1):e248093. doi: 10.1136/bcr-2021-248093.PMID: 36599491.
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REFINE-Lung implements a novel multi-arm randomised trial design to address possible immunotherapy overtreatment. Ghorani E , Quartagno M, Blackhall F, Gilbert DC, O'Brien M, Ottensmeier C, Pizzo E, Spicer J, Williams A, Badman P, Parmar MKB, Seckl MJ ; REFINE-Lung Investigators. Lancet Oncol. 2023 May;24(5):e219-e227. doi: 10.1016/S1470-2045(23)00095-5.PMID: 37142383 Review.
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Response and Outcomes of Maintenance Avelumab After Platinum-Based Chemotherapy (PBC) in Patients With Advanced Urothelial Carcinoma (aUC): "Real World" Experience. Bakaloudi DR, Talukder R, Lin GI, Makrakis D, Diamantopoulos LN, Tripathi N, et al. Clin Genitourin Cancer. 2023;21(5):584-93.
-
7 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
-
RET-MAP: An International Multicenter Study on Clinicobiologic Features and Treatment Response in Patients With Lung Cancer Harboring a RET Fusion. Aldea M, Marinello A, Duruisseaux M, Zrafi W, Conci N, Massa G, et al. J Thorac Oncol. 2023;18(5):576-86.
-
Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium. El Zarif T, Nassar AH, Adib E, Fitzgerald BG, Huang J, Mouhieddine TH, et al. J Clin Oncol. 2023;41(21):3712-23.
-
SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry. Cortellini A, Tabernero J, Mukherjee U, Salazar R, Sureda A, Maluquer C, et al. Lancet Oncol. 2023;24(4):335-46.
-
Second-line treatment outcomes after progression from first-line chemotherapy plus immunotherapy in patients with advanced non-small cell lung cancer. Auclin E, Benitez-Montanez J, Tagliamento M, Parisi F, Gorria T, Garcia-Campelo R, et al. Lung Cancer. 2023;178:116-22.
-
Small Bowel Lipomatosis: An Unusual Radiological Finding in Patients With Renal Cell Cancer on Pazopanib. Sharma A , Lakhani A, Ghosh-Ray S, Alam S, Padhani A, Gogbashian A, Nathan P . Anticancer Res. 2023 Feb;43(2):789-793. doi: 10.21873/anticanres.16219.PMID: 36697087.
-
Standard Versus Modified Ipilimumab, in Combination With Nivolumab, in Advanced Renal Cell Carcinoma: A Randomized Phase II Trial (PRISM). Vasudev NS, Ainsworth G, Brown S, Pickering L, Waddell T, Fife K, Griffiths R, Sharma A , Katona E, Howard H, Velikova G, Maraveyas A, Brown J, Pezaro C, Tuthill M, Boleti E, Bahl A, Szabados B, Banks RE, Brown J, Venugopal B, Patel P, Jain A, Symeonides SN, Nathan P , Collinson FJ, Powles T. J Clin Oncol. 2023 Nov 6:JCO2300236. doi: 10.1200/JCO.23.00236. Online ahead of print.PMID: 37931206.
-
Taxonomic reclassification of Kaposi Sarcoma identifies disease entities with distinct immunopathogenesis. Openshaw MR, Gervasi E, Fulgenzi CAM, Pinato DJ , Dalla Pria A, Bower M. J Transl Med. 2023;21(1):283.
-
Tebentafusp: a first-in-class treatment for metastatic uveal melanoma. Howlett S, Carter TJ, Shaw HM, Nathan PD . Ther Adv Med Oncol. 2023 Mar 21;15.
-
Temporary treatment cessation versus continuation of first-line tyrosine kinase inhibitor in patients with advanced clear cell renal cell carcinoma (STAR): an open-label, non-inferiority, randomised, controlled, phase 2/3 trial. Brown JE, Royle KL, Gregory W, Ralph C, Maraveyas A, Din O, Eisen T, Nathan P , Powles T, Griffiths R, Jones R, Vasudev N, Wheater M, Hamid A, Waddell T, McMenemin R, Patel P, Larkin J, Faust G, Martin A, Swain J, Bestall J, McCabe C, Meads D, Goh V, Min Wah T, Brown J, Hewison J, Selby P, Collinson F; STAR Investigators. Lancet Oncol. 2023 Feb 13.
-
The Effects of GCSF Primary Prophylaxis on Survival Outcomes and Toxicity in Patients with Advanced Non-Small Cell Lung Cancer on First-Line Chemoimmunotherapy: A Sub-Analysis of the Spinnaker Study. Anpalakhan S, Huddar P, Behrouzi R, Signori A, Cave J, Comins C, et al. Int J Mol Sci. 2023;24(2).
-
The price and value of therapeutic synergy in liver cancer. Pinato DJ , D'Alessio A, Celsa C, Manfredi GF, Fulgenzi CAM. Lancet. 2023;402(10408):1108-10.
-
Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma. Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, Milhem M, Chmielowski B, Kim KB, Carvajal RD, Hamid O, Collins L, Ranade K, Holland C, Pfeiffer C, Nathan P. N Engl J Med. 2023 Dec 14;389(24):2256-2266. doi: 10.1056/NEJMoa2304753. Epub 2023 Oct 21.PMID: 37870955.
-
8 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
-
Transcriptional landscape of 3D vs. 2D Ovarian Cancer Cell Models. Kerslake R, Belay B, Panfilov S, Hall M , Kyrou I, Randeva H, Hyttinen J, Karteris E, Sisu C. Cancers 2023, 15 , 3350. https://doi.org/10.3390/ cancers15133350.
-
Transversal psoas muscle thickness measurement is associated with response and survival in patients with HCC undergoing immunotherapy. Scheiner B, Lampichler K, Pomej K, Beer L, Balcar L, Sartoris R, et al. Hepatol Commun. 2023;7(10).
-
Treatment Rechallenge With Immune Checkpoint Inhibitors in Advanced Urothelial Carcinoma. Makrakis D, Bakaloudi DR, Talukder R, Lin GI, Diamantopoulos LN, Jindal T, et al. Clin Genitourin Cancer. 2023;21(2):286-94.
-
Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer. Lu H, Lou H, Wengert G, Paudel R, Patel N, Desai S, et al. Cell Rep Med. 2023;4(7):101092.
-
Tumor-infiltrating Neutrophils: Gatekeepers in Liver Cancer Immune Control. Scheiner B, Pinato DJ Gastroenterology. 2023;164(7):1338-9.
-
Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer. Cortellini A, D'Alessio A, Cleary S, Buti S, Bersanelli M, Bordi P, et al. Clin Cancer Res. 2023;29(14):2714-24.
-
Untargeted lipidomics reveal association of elevated plasma C18 ceramide levels with reduced survival in metastatic castration-resistant prostate cancer patients. Cattrini C, Manfredi M, Barboro P, Ghirimoldi M, Mennitto A, Martini V, et al. Sci Rep. 2023;13(1):17791.
-
Validation of the ONKOTEV Risk Prediction Model for Venous Thromboembolism in Outpatients With Cancer. Cella CA, Knoedler M, Hall M , Arcopinto M, Bagnardi V, Gervaso L, Pellicori S, Spada F, Zampino MG, Ravenda PS, Frassoni S, Passaro A, Milano M, Laffi A, Fazio N, Lordick F. JAMA Netw Open. 2023 Feb 1;6(2):e230010. doi: 10.1001/jamanetworkopen.2023.0010. PMID: 36795409; PMCID: PMC9936336.
-
What is the optimal duration, dose and frequency for anti-PD1 therapy of non-small cell lung cancer? Kuah CY, Monfries R, Quartagno M, Seckl MJ , Ghorani E . Ther Adv Med Oncol. 2023 Nov 10;15:17588359231210271. doi: 10.1177/17588359231210271. eCollection 2023.PMID: 37954230 Free PMC article.
The Trustees are confident that CTRT will continue to fund work that will lead to improvements in the detection, monitoring and treatment of cancer and care for patients with cancer.
REFERENCE AND ADMINISTRATIVE DETAILS Registered Company number CE025306 (England and Wales)
Registered Charity number
1194608
Registered office
Upper East Research Office Mount Vernon Hospital Rickmansworth Road Northwood HA6 2RN
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
TRUSTEES REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
The Trustees:
Professor Gordon Rustin Professor Michael Seckl Professor Marcia Hall Professor Paul Nathan Dr Anand Sharma Dr Andreas Polychronis Dr David Pinato Dr Ehsan Ghorani Kiran Grewal Russell Hallam
Statement of Trustees responsibilities
The trustees (who are also the directors of The Cancer Treatment And Research Trust CIO for the purposes of company law) are responsible for preparing the Report of the Trustees and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).
Company law requires the trustees to prepare financial statements for each financial year which give a true and fair view of the state of affairs of the charitable company and of the incoming resources and application of resources, including the income and expenditure, of the charitable company for that period.In preparing those financial statements, the trustees are required to
-
select suitable accounting policies and then apply them consistently;
-
observe the methods and principles in the Charity SORP;
-
make judgements and estimates that are reasonable and prudent;
-
state whether applicable accounting standards have been followed, subject to any material departures disclosed and explained in the financial statements;
-
prepare the financial statements on the going concern basis unless it is inappropriate to presume that the charitable company will continue in business.
The trustees are responsible for keeping proper accounting records which disclose with reasonable accuracy at any time the financial position of the charitable company and to enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the charitable company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.
In so far as the trustees are aware:
- there is no relevant information of which the charitable company's independent examiner is unaware; and - the trustees have taken all steps that they ought to have taken to make themselves aware of any relevant information and to establish that the Independent examiner is aware of that information.
Signed on behalf of the Trustees
12 February 2025
..................
Professor Michael Seckl- Trustee
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
INDEPENDENT EXAMINER'S REPORT
TO THE OF THE CANCER TREATMENT AND RESEARCH TRUST CIO
I report to the trustees on my examination of the financial statements of The Cancer Treatment and Research Trust CIO (‘the charity’) for the year ended 31 December 2023 which comprise the Statement of Financial Activities, the Balance Sheet and related notes.
This report is made solely to the charity’s trustees, as a body, in accordance with section 145 of the Charities Act 2011. My work has been undertaken so that I might state to the charity’s trustees those matters I am required to state to them in this report and for no other purpose. To the fullest extent permitted by law, I do not accept or assume responsibility to anyone other than the charity and the charity’s trustees as a body, for my work, for this report, or for the opinions I have formed.
Responsibilities and basis of report
As the trustees of the charity you are responsible for the preparation of the financial statements in accordance with the requirements of the Charities Act 2011 (‘the Act’).
I report in respect of my examination of the charity’s financial statements carried out under section 145 of the Act and in carrying out my examination I have followed all the applicable Directions given by the Charity Commission under section 145(5)(b) of the Act.
An independent examination does not involve gathering all the evidence that would be required in an audit and consequently does not cover all the matters that an auditor considers in giving their opinion on the financial statements. The planning and conduct of an audit goes beyond the limited assurance that an independent examination can provide. Consequently I express no opinion as to whether the financial statements present a ‘true and fair’ view and my report is limited to those specific matters set out in the independent examiner’s statement.
Independent examiner's statement
Since the CIO’s gross income exceeded £250,000 your examiner must be a member of a body listed in section 145 of the 2011. I confirm that I am qualified to undertake the examination because I am a member of ICAEW, which is one of the listed bodies.
I have completed my examination. I confirm that no material matters have come to my attention in connection with the examination giving me cause to believe that in any material respect:
-
accounting records were not kept in respect of the charity as required by section 130 of the Act; or
-
the financial statements do not accord with those records; or
-
the financial statements do not comply with the applicable requirements concerning the form and content of accounts set out in the Charities (Accounts and Reports) Regulations 2008 other than any requirement that the accounts give a ‘true and fair view which is not a matter considered as part of an independent examination.
I have no concerns and have come across no other matters in connection with the examination to which attention should be drawn in this report in order to enable a proper understanding of the financial statements to be reached.
Andrew Millet BA MBA FCA
A fellow member of the Institute of Chartered Accountants in England and Wales. Millet Accountants Ltd Beyond Aldgate Tower 2 Leman Street Aldgate London E1 8FA
12 February 2025
Dated: .........................
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
STATEMENT OF FINANCIAL ACTIVITIES INCLUDING INCOME AND EXPENDITURE ACCOUNT
FOR THE YEAR ENDED 31 DECEMBER 2023
| Unrestricted Restricted funds funds 2023 2023 Notes £ £ Income from: Donations and legacies 2 103,889 63,648 Investments 3 12,201 - Total income 116,090 63,648 Expenditure on: Raising funds 4 5,708 - Charitable activities 5 78,392 96,539 Other expenditure 9 42,403 - Total expenditure 126,503 96,539 Net income/(expenditure) and movement in funds (10,413) (32,891) |
Total Unrestricted Restricted funds funds 2023 2022 2022 £ £ £ 167,537 108,720 269,727 12,201 3,393 - 179,738 112,113 269,727 5,708 4,214 - 174,931 86,467 77,143 42,403 34,683 - 223,042 125,364 77,143 (43,304) (13,251) 192,584 |
Total 2022 £ 378,447 3,393 |
|---|---|---|
| 381,840 | ||
| 4,214 163,610 34,683 |
||
| 202,507 | ||
| 179,333 |
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
BALANCE SHEET
AS AT 31 DECEMBER 2023
| Unrestricted Fund Notes £ Fixed assets Intangible assets 11 1672 Tangible assets 12 625 Investments 13 6,469 8,766 Current assets Debtors 14 4,196 Cash at bank and in hand 675,130 679,326 Creditors: amounts falling due within one year 15 (11,661) Net current assets 667,665 Total assets less current liabilities 676,431 Net assets 676,431 The funds of the Charity Restricted income funds - general Unrestricted funds - general |
2023 2022 Restricted Fund Total funds Total funds £ £ £ 1,672 0 625 906 6,469 6,469 8,766 7,375 4,196 32,864 509,038 1,184,168 1,238,391 509,038 1,188,364 1,271,255 (11,661) (49,855) 509,038 1,176,703 1,221,400 509,038 1,185,469 1,228,775 509,038 1,185,469 1,228,775 285,549 541,995 899,920 686,780 1,185,469 1,228,775 |
|---|---|
The notes on pages 17 to 22 form part of these financial statements.
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
BALANCE SHEET (CONTINUED)
AS AT 31 DECEMBER 2023
The charitable company is entitled to exemption from audit under Section 477 of the Companies Act 2006 for the year ended 31 December 2023.
The members have not deposited notice, pursuant to Section 476 of the Companies Act 2006 requiring an audit of these financial statements.
The trustees acknowledge their responsibilities for
(a) ensuring that the charitable company keeps accounting records that comply with Sections 386 and 387 of the Companies Act 2006 and
(b) preparing financial statements which give a true and fair view of the state of affairs of the charitable company as at the end of each financial year and of its surplus or deficit for each financial year in accordance with the requirements of Sections 394 and 395 and which otherwise comply with the requirements of the Companies Act 2006 relating to financial statements, so far as applicable to the charitable company.
These financial statements have been audited under the requirements of Section 145 of the Charities Act 2011.
The financial statements were approved by the Board of Trustees and authorised for issue on ............................................. and were signed on its behalf by: 12 February 2025
..............................
Professor Michael Seckl-Trustee
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023
1 Accounting policies
1.1 Accounting convention
Basis of preparing the financial statements
The financial statements of the charitable company, which is a public benefit entity under FRS 102, have been prepared in accordance with the Charities SORP (FRS 102) 'Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019)', Financial Reporting Standard 102 'The Financial Reporting Standard applicable in the UK and Republic of Ireland' and the Companies Act 2006. The financial statements have been prepared under the historical cost convention, with the exception of investments which are included at market value.
Going concern:
At the time of approving the financial statements, the trustees have a reasonable expectation that the charity has adequate resources to continue in operational existence for the foreseeable future. Thus the continue to adopt the going concern basis of accounting in preparing the financial statements.
The trustees consider that there are no material uncertainties about the charity's ability to continue as a going concern
1.2 Charitable funds
1.3 Income
All income is recognised in the Statement of Financial Activities once the charity has entitlement to the funds, it is probable that the income will be received and the amount can be measured reliably.
Donations and legacies are provided to the Charity, in order that the Charity can fulfil its purpose.
1.4 Expenditure
Liabilities are recognised as expenditure as soon as there is a legal or constructive obligation committing the charity to that expenditure, it is probable that a transfer of economic benefits will be required in settlement and the amount of the obligation can be measured reliably. Expenditure is accounted for on an accruals basis and has been classified under headings that aggregate all cost related to the category. Where costs cannot be directly attributed to particular headings they have been allocated to activities on a basis consistent with the use of resources.
1.5 Investments
Fixed asset investments other than programme related investments, are included at market value at the balance sheet date,
Realised gains and losses on investments are calculated as the difference between sales proceeds and their market value at the start of the year, or their subsequent cost, and are charged or credited to the Statement of Financial Activities in the period of disposal.
Unrealised gains and losses represent the movement in market values during the year and are credited or charged to the Statement of Financial Activities based on the market value at the year end.
1.6 Intangible fixed assets other than goodwill
Website 10% on reducing balance
- 15 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
1 Accounting policies
(Continued)
1.7 Tangible fixed assets
Depreciation is provided at the following annual rates in order to write off each asset over its estimated useful life.
Plant and equipment 25% on reducing balance Computer equipment 33% on reducing balance
1.8 Cash and cash equivalents
Cash and cash equivalents include cash in hand, deposits held at call with banks, other short-term liquid investments with original maturities of three months or less, and bank overdrafts. Bank overdrafts are shown within borrowings in current liabilities.
The charity opted to adopt Bulletin 1 published on 2 February 2016 and have therefore not included a cash flow statement in these financial statements.
1.9 Financial instruments
The Charity has elected to apply the provisions of Section 11 ‘Basic Financial Instruments’ and Section 12 ‘Other Financial Instruments Issues’ of FRS 102 to all of its financial instruments.
Financial instruments are recognised in the Charity's balance sheet when the Charity becomes party to the contractual provisions of the instrument.
Financial assets and liabilities are offset, with the net amounts presented in the financial statements, when there is a legally enforceable right to set off the recognised amounts and there is an intention to settle on a net basis or to realise the asset and settle the liability simultaneously.
Basic financial assets
Basic financial assets, which include debtors and cash and bank balances, are initially measured at transaction price including transaction costs and are subsequently carried at amortised cost using the effective interest method unless the arrangement constitutes a financing transaction, where the transaction is measured at the present value of the future receipts discounted at a market rate of interest. Financial assets classified as receivable within one year are not amortised.
Basic financial liabilities
Basic financial liabilities, including creditors and bank loans are initially recognised at transaction price unless the arrangement constitutes a financing transaction, where the debt instrument is measured at the present value of the future payments discounted at a market rate of interest. Financial liabilities classified as payable within one year are not amortised.
Debt instruments are subsequently carried at amortised cost, using the effective interest rate method.
Trade creditors are obligations to pay for goods or services that have been acquired in the ordinary course of operations from suppliers. Amounts payable are classified as current liabilities if payment is due within one year or less. If not, they are presented as non-current liabilities. Trade creditors are recognised initially at transaction price and subsequently measured at amortised cost using the effective interest method.
1.10 Taxation
The charity is exempt from corporation tax on its charitable activities.
- 16 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
1 Accounting policies (Continued)
1.11 Fund accounting
Unrestricted funds can be used in accordance with the charitable objectives at the discretion of the trustees.
Restricted funds can only be used for particular restricted purposes within the objects of the charity. Restrictions arise when specified by the donor or when funds are raised for particular restricted purposes.
Further explanation of the nature and purpose of each fund is included in the notes to the financial statements.
1.12 Pension costs and other post-retirement benefits
The charitable company operates a defined contribution pension scheme. Contributions payable to the charitable company's pension scheme are charged to the Statement of Financial Activities in the period to which they relate.
2 Income from donations and legacies
| Donations Gift aid Other income |
2023 £ 157,787 8,575 1,175 167,537 |
2022 £ 334,133 3,888 40,426 |
|---|---|---|
| 378,447 |
3 Income from investments
| Dividends Deposit account interest 4 Expenditure on raising funds Fundraising and publicity Seeking donations, grants and legacies |
2023 £ 345 11,856 12,201 2023 £ 5,708 |
2022 £ 217 3,176 |
|---|---|---|
| 3,393 | ||
| 2022 £ 4,214 |
- 17 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
5 Expenditure on charitable activities
| Research salaries Research expenses and lab fees Grants to Institutions Conference and Meeting Event Expenses Share of support and governance costs (see note 6) Support 6 Support costs allocated to activities Other resources expended Management Finance Governance Cost |
2023 £ 31,608 91,504 45,000 2,209 4,610 174,931 42,403 42,403 2023 £ 22,114 2,420 17,869 42,403 |
2022 £ |
|---|---|---|
| 70,237 73,619 4,715 15,039 0 |
||
| 163,610 | ||
| 34,683 | ||
| 34,683 | ||
| 2022 £ 21,392 1,039 12,252 |
||
| 34,683 |
7 TRUSTEES' REMUNERATION AND BENEFITS
There were no trustees' remuneration or other benefits for the year ended 31 December 2023.
Trustees' expenses
During the year £574.8 of expenses were paid to Dr Nathan relating to Membership expenses.
8 Employees
- 18 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED)
FOR THE YEAR ENDED 31 DECEMBER 2023
| Employment costs Wages and salaries Social security costs Other pension costs The average monthly number of employees during the year was as follows: Secreterial/Administration: There were no employees whose annual remuneration was more than £60,000. |
2023 £ 14,000 329 233 14,562 2023 1 |
2022 £ 14,248 275 170 |
|---|---|---|
| 14,693 | ||
| 2022 1 |
9 Other Expenditure
| Subscriptions Travel and Subsistence Wages Staff recruitment Pensions Insurance Staff Training Telephone Postage and stationery Advertising Computer expenses Plant and machinery Computer equipment Website Sundries Bank charges Accountancy and legal fees |
2023 £ 3,112 - 14,000 329 233 574 275 76 448 1,526 882 64 217 186 192 2,420 17,869 42,403 |
2022 £ 2,690 134 14,248 275 170 284 52 65 300 2,199 564 85 326 - - 1,039 12,252 |
|---|---|---|
| 34,683 |
10 Taxation
The charity is exempt from taxation on its activities because all its income is applied for charitable purposes.
- 19 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
11 Intangible fixed assets
| 11 | Intangible fixed assets | |||
|---|---|---|---|---|
| Website | ||||
| £ | ||||
| Cost | ||||
| At 1 January 2023 | - | |||
| Additions - separately acquired | 1,858 | |||
| At 31 December 2023 | 1,858 | |||
| Amortisation and impairment | ||||
| At 1 January 2023 | - | |||
| Amortisation charged for the year | 186 | |||
| At 31 December 2023 | 186 | |||
| Carrying amount | ||||
| At 31 December 2023 | 1,672 | |||
| At 31 December 2022 | - | |||
| 12 | Tangible fixed assets | |||
| Plant and | Computers | Total | ||
| equipment | ||||
| £ | £ | £ | ||
| Cost | ||||
| At 1 January 2023 | 254 | 652 | 906 | |
| At 31 December 2023 | 254 | 652 | 906 | |
| Depreciation and impairment | ||||
| Depreciation charged in the year | 64 | 217 | 281 | |
| At 31 December 2023 | 64 | 217 | 281 | |
| Carrying amount | ||||
| At 31 December 2023 | 191 | 435 | 625 | |
| At 31 December 2022 | 254 | 652 | 906 |
- 20 -
Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
13 Fixed asset investments
| Listed | |
|---|---|
| investments | |
| £ | |
| Cost or valuation | |
| At 1 January 2023 & 31 December 2023 | 6,469 |
| Carrying amount | |
| At 31 December 2023 | 6,469 |
| At 31 December 2022 | 6,469 |
14 Debtors
| Amounts falling due within one year: Trade debtors Prepayments and accrued income Creditors: amounts falling due within one year Social security and other taxes Accruals and deferred income Accrued expenses Other creditors |
2023 £ - 4,196 4,196 2023 £ 38 - 11,488 135 11,661 |
2022 £ 29,792 3,072 |
|---|---|---|
| 32,864 | ||
| 2022 £ 317 4,500 18,036 27,002 |
||
| 49,855 |
15 Creditors: amounts falling due within one year
16 Unrestricted funds
The unrestricted funds of the charity comprise the unexpended balances of donations and grants which are not subject to specific conditions by donors and grantors as to how they may be used. These include designated funds which have been set aside out of unrestricted funds by the trustees for specific purposes.
| At Unrestricted Funds Restricted funds |
1 January 2023 Incoming resources Resources expended £ £ £ 686,780 116,090 (126,503) 541,995 63,648 (96,539) 1,228,775 179,738 223,042 |
Transfers Gains and losses At 31 December 2023 £ £ £ 253,555 (30,002) 899,920 (253,555) 30,000 285,549 - - 1,185,469 |
Transfers Gains and losses At 31 December 2023 £ £ £ 253,555 (30,002) 899,920 (253,555) 30,000 285,549 - - 1,185,469 |
|---|---|---|---|
| 1,185,469 |
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Docusign Envelope ID: AB1D42D0-54D5-4733-B39F-E1A62D9F4D30
THE CANCER TREATMENT AND RESEARCH TRUST CIO
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023
| 16 Unrestricted funds Previous year: At Unrestricted Funds Restricted funds |
1 January 2022 Incoming resources Resources expended £ £ £ 700,031 112,113 (125,364) 349,411 269,727 77,143 1,049,442 381,840 202,507 |
(Continued) Transfers Gains and losses At 31 December 2022 £ £ £ - - 686,780 - - 541,995 - - 1,228,775 |
|---|---|---|
17 Related party transactions
There were no related party transactions for the year ended 31 December 2023 or for 31 December 2022.
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