Company R*gistratth number.. 10887014 (En￿all& and Walesl Charity number: 1194431 HEALTH DATA RESEARCH UK (a company limited by guarantee) ANNUAL REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2024 "JDHL6KP* 09112r2024 c￿1PANIEs HOUSE AI6 #i&$ HEALTH DATA RESEARCH UK LEGAL ANO ADMINISTRATIVE INFORMATION FOR THE YEAR ENDED 31 MARCH 2024 CONTENTS Pagès Leeal and Adminlstraii¥e Infomiation Trustees. Report Independent Auditorfs Aeport 25 Statement ol Finan¢ial Actl¥ities 28 Balance Sheei 29 Statement of Cash flows 30 Notes to the Finanttal StatÈmÈnts 31 HEALTh DATA RESEARCH UK LEGAL AND ADMINISTRATIVE INFORMATION FOR THE YEAR ENDED 31 MARCH 2024 Trustees and Oiiettors Dr Graham Spittle. C8E. Chair- retl￿d 26.07.2023 Dame Julie M¢)ore, Chair-app)inied 26.07.2023 Patsy Wilkin50n. Deputy Chair-appointed OS.10.2023 Professor Sir ￿eX Markham, retired as trustee 08.11.2023 ProfessorSwJames Srnith retsred astrustee 08.11.2023 ProfEssor Darne Janet T￿)rnton retired as trv#ee 08.11.2023. reappointed 21.03_2024 Professor Sarah Harper C8E. retired a5 trustee 20.06.2024 Lord JarneslySha￿hnessY Wiliam Boa Alison Wikox Dr kndrew Ekter Professor The lord Ara Datti- rewBned 22_03.2024 Dr Oaire Bithell Mark Walptyt-re>gThed OS.06.2024 DT Claire Ne￿and Drjunaid 6aiwa-appotnted 01.04.2024 Dr Prabhu Arumu8am •appointed l July 2024 Profe$50r julia PJi50n Noble. C8E- appointed l SeptembEr 2024 P¢ofessor Nilesh Samani- appointed I September 2024 Sir Dav¥1 Sknn*n-apwxnted I September2024 Company fegi51ered number 10887014 Re￿ttered offKe Wellcome YNst Gibbs Buildir 215 Eu5ton Road London NW128E Prlnupal operadn8 1)ffi 215 Eusion Road London NWI 28E Auditor Hav51fbat￿tyre LLP 10 Queen Street Place London EC4R IAG Company sttr*t*ry Eltment31 cam￿NY kneiary knmited Bankers Narwest 250 8ishops8ate London EC2M 4 Soliotors "rd & Bird LLP 12 New Fttter Lane London EC4A IIP HEALTH DATA RESEARCH UK HDRUK TRUSTEES, REPORT FOR THE YEAR ENDED 31 MARCH 2024 Foreword The Trustees are pleased to present their Strategic report for Health Data Research UK I-HDR UK-, the "Company", the "Institute") for the year ended 31 March 2024. This report provides a review of the actNities and business for Health Data Research UK and outlines its development and performance for the financial year. the financial position at the end of the year and an ouiline of its plans. The report also describes how the risks facing Health Daia Research UK are managed. Overview Health Data Research UK'S S-year strategy, a5 set-out in the Quinquennial Review IQQRI. wa5 fully endorsed bv International peer-review arhd the Institvte's core funders in 2022. While providing the framework of a SiBnificant proportion of Health Data Research UK'S research. infrastrurture and partnership programmes. it is vital that the Institute responds to changes in the landscape and rnaintain5 a focus on delivering outcomes and impacts that only a national Insiitute can deliver. Following the successful QQR. our core funders- nine of the largest government and charity research funders in the UK - awarded us £71.3 million for the years 2023 to 2028. This increase in funding places the institute in prime position to build on its success. The achievement5 highlighted in the report below. are a result of the commitment and dedication of the many teams across Health Data Research UK'S distributed national Instrtute. our partners and our patient and public advisors. It is a testameni to their focus on our Values of transparency, optimism. respect, courage and humility that we have made such progress. As we irnplement our refreshed strategy. we look forward to working with our partners and community, strengthening our connections and to focus on deliverin8 novel insights and innovatNe data research and services to enable discoveries that improve people's lives. HEALTH DATA RESEARCH UK TRUSTEES. REPORT FOR THE YEAR ENDED 31 MARCH 2024 Strategic Report Business and •¢tivity review The UK is in a unique position thank5 to the NHS and its cradle-tO-8rave records for 65 million people. Safe and secure use of this data could improve treatments. deliver better health and care and save live5. however. it can take years to find, access and 'wrangle' data from different plaos into a state that researchers can use for analysis. Health Oata Research UK is the national instilute for health data that includes England. Scotland, Wales and Northern Ireland with a rnission to accelerate trustworthy data use to enable discoverie5 that improve people's lives. Our 20-year vision is for large-scale data to benefit every interaction with patients. every clinical trial and every biomedical discovery. and to transform publit health. We work in partnership with the NHS. industry. charities and universities to realise the potential of the UK'S wealth of health data in life-changing research. Patients and the public a￿ actively involved in shaping Health Data Research UK'S work and ensuring it deliver5 public benefit. We are a multi-dis¢iplinary, geographically distributed, UK-wide Institute of over Is￿ researchers across more than 39 organisations. During the year. the Institute has engaged a broader UK and intreasingly global commvnitv spanning the National Health Service INHSI. research institutes. industry. charities. government and regulators with more than 500 organisations collaboraiing on programmes of health dala research initiated and enabled bv the Institute. Health Data Research UK'S strategy was significantty updated as part of the Institute's 5-year funding renewal and the period from April 2023 through to March 2024 has seen Health Data Research UK delNering against its three strategic goal5= l. A¢celeraiin£ trustworthy data use by implementing a national research data strategy and assembling infrastructure and service5 aligned to research and innovation needs. 2. Empowering researchers by valuing people with diverse perspectives and Skills, committed to open and team science to advance scientbfic discoveries and deliver pattent and public benefit. 3. Promotin8 partnerships by building and maintaining critical partnerships. aligning incentives and reducing complexity across a fragmented landscape to streamline health dota science. Achievements and Performance As an integral part of our strategy, five research driver programmes were kickstarted in late 2023 with the aim io test and improve trustworthy health data infrastruciure forthe wider benefit of the research community. Each programme has a focus on an area where data sctence has great potential to improve public health, prevent people from becomin8 unwell, and enhance patient care-. Bi8 Data lor Complex Disease is harnessing whole population. national linked health data to improve the under5tandin& prevention and early diagnosis of cancer, cardiovascular conditions and other complex diseases. Inflammation and Immunity is seeking to better understand the epidemiology of allergic and respiratory conditions across the UK and identify opportunities to reduce inequalities in care. Molecules to Health Records is bringing together information on genomics. other molecular trait5, and. electronic health records at scale. Medicines in Acute and Chronic Care aimsto understand and transform the use of medicines for patients of all aEes. especially those with complex care needs caused by multiple long-term condition5. HEALTH DATA RESEARCH UK TRUSTEES. REPORT FOR THE YEAR ENDED 31 MARCH 2024 Social and Environmental Oeterminants of Health bs focussing on developing national infrastructure and methods to connect different types of Social and environmental data with health data to gain new insights about the wider (Jeterminènts of health. The area of Brain Health has quickly ev0￿ed into a strategic empha515 for Health Data Research UK.. In lune 2023 A new UK-wide researth platform was anrbounced. The UK-T81 REp05itory and data PORTal Enabling discoveRy ITBI-REPORTERI - to be led by the University of Cambridge in collaboration with Health Data Research UK will boost the use of data to advance treatment and care for people wtth traumatic brain injury. The platform h35 received £9.$ million in funding from the Medical Research Council IMRCI. the National Institute for Health and Care Research INIHRI. the Ministry of Defence and Alzheimerfs Research UK. In the same month Health Data Research UK launched the NEURii collaboration which aims to translate healthcare data and digital sciences into project5 that can enhance the quality of life of people living With dementia and contribute to a national data infrastructure in the UK. The two-year pilot will use high-quality. real- world data alongside artificial intelligence IAII and machine learning IMLI to deliver projects that have the potential to make a meaningful difference to patient5. lives while maintaining data securrty and public trust. The early part of 2024 saw significant progress with two partnership discussions bearing fruit. In February Health Data Research UK and the UK Dementia Research Institute (UK DRI) were invitetl by the Medical Research Council IMRCI to develop a £20 million fundin8 proposal to create a Dementia Tria15 Acceleratorwhich complement5 the work of the eovernment's Dementia Mission. In August 2023, a UK Research and Innovation IUKRII report hi8hlighted the need for action to reach the target of net-zero digital research infra5tructure5 by 2040. Dr Loic Lannelongue. Research Associate. University of Cambridge and Prof Michael Inouye. University of Cambridge and Baker Heart and Oiabetes Research Institute, developed an online calculator to help scientists easity estimate the carbon footprint of a computation. Thev then developed GAHPC. a version of the calculator tailored to high-perfom)ance computing IHPCI infrastructures. These open-source and open-actess tools have had approximately 200 users per week and to Ilate has had 24,1KJO over811 Users from around the world. making it easier for thern to track their energy usage and implement broader reporting of carbon footprints. In October 2023 a new iniliative launched by Health Data Research UK (HDR UKI and funded by the Medical Research Council IMRCI enabled Nineteen projects. each with the aim of improving the clarity and accessibility of information about data access processes for the public and researchers. The Transparency Standards are designed to support data custodrans in improving thè clarity and accessibility of information about data access processes for the public and researchers. On 22 May 2024 we hosted a special in-person event in London to celebrate the project outputs. The UK Health Data Research Alliance marked five remarkable years of progress and commitment to maximising the benefits of health data research for all. Over the past 5 years the alliance has Brown arbd diver5rfied its membership.. from nine founding members to a network of over 10) organi5ation5 today, and expansion beyond data custodian5. It has accelerated access to health data for vital research during the COVID-19 pandemic with Alliance member5 having developed a unified approach to data discovery and access. aligning processes acfOS5 the four nations. And critically, it has improved transparency in the use of health data for research by pioneered a data use register standard to 5UPPOrt consistent and accessible public records of data usage. Te3ms have made significant progres5 acr055 the rapid data-driven project5 to identify and tackle winter pressures in the health Ca￿ system. Led by Professor Liz Sapey. Direclor of the Institute of Inflammation and A8eing at the Unbversity of Birmingham. researchers have developed a prediction tool to improve the flow of patients through Same Day Emergency Care ISDECI- a way of treating emergency patients who would otherwise be admitted to hospital. The project highlighted that previously used tools, developed in specific population5, are less effective in a diverse urban centre. The team is now working with trusts to look at the workforce implications of using their new tool and aim to publish their findings in the fvIu￿. HEALTH DATA RESEARCH UK TRUSTEES. REPORT FOR THE YEAR ENDED 31 MARCH 2024 Health Data Research UK enabled whole population-based research in England during the pandemic. A Trusted Research Environment ITREI for England was created early in the pandemic with health data covering >54 million people, thanks to a collaboration between NHS England and Health Data Research UK. This allowed the first research study of health records for 67 million people in all four UK natKJns- published in the Lancet in January 2024. It looked at gaps in Covid-19 vaccine coverage and found that between a third and a half of the population5 of the four UK nations had not had the reeomrnended number of vaccinations and boosters by summer 2022. The approach coultd be extended to many other areas of medicine with great potential for new discoveries in the understanding and treatment of disease. This study marked a significant milestone in Health Data Research VK'5 mission to unite the UK's health data to enable discoveries that irnprove people's lives arbd demonstrates the value and potential ol wpulation-wide health data studies. BHF DSC Launched in January 2020 as a partnership between Health Data Research UK and the British Heart Foundation, the BHF Data Science Centre IBHF DSC) enables responsible, ethical research that combines the power of advanced anatytic methods wTrth the UK'S large-scale and diverse tardiovascular data. The DSC continue5 to develop strategic partnerships and following on from the launch in September 2023 of the Stroke Data Science Cata￿St - a strategic partnership with the Siroke Association and the BHF- the centre ha5 established a partnership with Kidney Research UK and the BHF to launch the Kidney Data Science Calalyst. The Public Advisory Group IPAGI ha5 grown from 17 to 26 public contributors. Throughout the year. their invaluable contributions have had a significant impact on varTrous aspects of the centres work. including participation on funding panels to select ￿searCh projects forfunding. The PAG convenes quarterty and has been instrumental in ensuring thal work remains patient-centric and relevant to the public. Key achievement5 made this year include: Through the CVD-COVID-U COVID-IMPACT consortium the DSC supported the largest ever study to be conducted in the UK on 67 million people across all four nations. The study. published in The Lancet looked at the risk associated with COVID-19 under-vaccination and showed under-vaccination was linked with an increased risk of COVID-related hospitalisations or deaths. The health data science team have been developing curation and analysis too15 and resources to support researchers conducrin8 research using whole population data in national secure data environments. These resources are crucial to speed up research and ensure it is of hiEh quality. Published a re ort on prioritising the types of data that should be collected from wearables and shared for research- taking into account public and researcher views. One of the public contributors involved in Ihi$ Study featured in local rnedia Maidenhead Advertiser and BBC Berkshirel. explaining why she got involved. The DSC Submitted a fvnding application to Smart Data Research UK to develop J range of tools and seNices for the research community to enable research using data from smartphones. wearables and medical (Jevices in a safe and secure way. Working with Swansea University SeRP and SAIL Databank to grow the number of disease-based cohorts that Use the clinical research cohorts trusted research environment ITREI to link individual with other types of health data in a safe and secure environment, to better understand the causes and consequence5 of disease. Proce￿e$ have been established to streamline and support researchers with onboarding data. Worked with the research community to identify requirements enabling the curation of phenotyping algorithms for the cardiometabolic community and ensuring they are FAIR (Findable. Accessible. Interoper3ble antl Reusable). Published recommendations and a news iece highlighting how these recommendations support reproducible and efficient ￿Search. Theteam is now ensuring all phenotyping HEALTH OATA RESEARCH UK TRUSTEES, REPORT FOR THE YEAR ENDED 31 MARCH 2024 3lgorithms created or used as part of ihe CVD-COVID-UKICOVIO-IMPACT consortium are available in the HDR UK Pheno e Libra The DARE UK {Data and Analytics Research Environments UK) programme The DARE UK programme is funded by UKRI as part of its Di ital Research Infrastrurture portfolio of investments, which supports the development of a coordinated vision for digital research infrastructure in the UK. DARE UK is a parb-UKRI. cross-domain programme its scope covers all tYr￿S of sensitive data. including data abDUt education, health. the environment and much more. There is growin8 consensus (including from Phase l DARE K recommendations ihe Goldacre Review the UK Health Data Research Alliance TRE Green er and the DHSC Data Saves Lives policy paperl that all sen51tive data should only be acce55ed and analysed by researchers within a Trusted Research Environment ITREI. Central to the DARE UK Pfogramme's ambition is to enable and support the development of a national interoperable network of secure digit31 ￿Search infrastructures or TRES, laying the foundation for an ecosystem of nexi-8eneration TRE5 for advanced data research for the public 800d. Delivery of Phase l of the programme began in July 2021 and has been deliVe￿d with joint oversight from Health Data Research UK and ADR UK. Phase I was an extensive programme of community engagement that formed the found3tion for developing a clear vision of the needs of different research communitie5. and to address the interest5 and concern5 of the public around the use of sensitive data for research. Phase I has included.. An initial landsca vi w and a more recent infrastructure landsc e review to rnform undersianding of the digital and Structural foundations that underpin sensitive data research across the UK.. Two portfoli05 of funded projects, the DARE UK S rint Exem lar Pro ects and DARE UK Driver Pro ects that have tested and developed earfy thinkbng and proof of concepts bn key a￿a$ of the programmes vision.. A Phase I recommendations report settin8 Out several findings and recommendations of the programme from Phase I with the aim of establishing the key challenges across the data research landscape, and firsts steps on how to overcome them to better support data research at Sca￿ for the benefit of society.. A Public Dialo ue to explore public views regarding what a more joined-up. efficient and trustworthy national data research infrastructure should look like- The DARE UK Communit Grou s initiative linclvding funding) aimed at encouraging different communrties within the UK 5en5itive data research landscape to co-create components and pieces of work that align with the programrne'5 vision- The ongoing development of a draft federated architecture blueprint to examine the prerequi51tes and tools required to create a secu￿, connected, and interoperable network of TRES lor sensitive data research across the UK (the next version of the Llraft is in progress,. The ongoing development of inter-di5ciplinary. cross-domain scientific use cases linking different types of sensitive data together at scale to enable research that benefits the public Ireport to be published after the pre-election periodl. HEALTH DATA RESEARCH UK TRUSTEES. REPORT FOR THE YEAR ENDEO 31 MARCH 2024 Communications and engagement The Health Data Research UK Communications and Policy Team has built upon the successes of the previou5 year and delivered on increasing Health Data Research UK'S reach through workinE Wlth the media, strategic communications campaigns. event5 and communicating impact on Health Data Research UK digital channels. Health Oata Research UK's digital channels continue to go from strength to strength. Between l April 2023 and 31 March 2024 was visited 284,998 times by 187,266 users. The Health Data Research UK webslte links to the Alliance website. the Health Data Research UK Future5 training platform and the Gateway to provide users with a clear route to discover more detailed, tailored infomiation in response to their user need. We have seen a significant increase in our social media succes5 measures across the 2023124 financial year. We have seen a 34% increase in followers across our social media channels compared to the previou5 financial year. Our Linkedln followers have increased by 5,969 and our Twttterlx followers have increased by 1,380. At the end of the financial year our follower count was 13.050 on Twitter X and our follower count was 15.847 ort Linkedln. Our monthly institute email newsletter, HIVE, continues to provide a concise update on key artivities and developments across the organisation to over 6.700 people, an increase of 335 Subscribers. The 8lack Internship Programme was one of the major projects supported by the communications team this year. Health Data Research UK successfully attracted many talented Black data scientists to apply for the programme and partnered with community TV stations and healthcare podcasts to enable the interns to share their story globally, further promoting the programme. Health Data Research UK'S annual conference on 5-6 March 2024, trtled 'The Grand Challenges in Health Data,, discussed the global challenges in health data research. featuring talks from internationally leading figures across the health data and technology research sector. The two-day event included interactive panel discu55ions, keynote sessions, an exhibitor area, as well as networking opportunities throughout the day. The 2024 conference wa5 a two-day hybrid event held in Leeds at the Royal Armourles Museum. It was highly successful, with over 7￿ attendees present in person over the two days. and an additional 570 attendee5 participating online. HEALTH DATA RESEARCH UK TRUSTEES. REPORT FOR THE YEAR ENDED 31 MARCH 2024 Patient and Public Involvement and Engagement Health Data Research UK has demonstrated leadership in promoting transparency and trustworthiness to the public by embedding Patient and Public Invofvement and Engagemenl IPPIEI activities in governance, infrastructure developments, and research. A prime example of this 15 the contribution of Health Data Research UK'S Public Advisory Board IPABI to the development of Tran5 arenc Standards. These standard5, informed by the PAB'S mission to ensure clear communication of data access rocedures with members of the ublic have been Crucial in guidirbg Health Data Research UK'S approach. From ihe im lementaiion of these standards to the celebration of im act PAB members made the drfference and rneaningfully contributed to the strategic thinking and work of Health Data Research UK. However, throughout the year, Health Data Research UK has hugely benefitted from the significant contributions of many more public mernbers invofved in PPIE activities across the Institute. These include HDR UK Voic British Heart Foundation's Data Science Centres IBHF DSC) Public Advi50ry Group, and OARE UK'S Programme Board and Public Advisory Group. CollectNely. th.ese groups have made a significant impact. ensuring Health Data Research UK'S activities are drNen by the goal of delivering benefits to patients and the public. The range of PPIE attivities they have been invofved in over the 202312024 year include.. Played an integral role in the HDR UK Stories cam engagement in health (Jata.. n sharing personal experiences to inspire involvement and Took an active role in the planning and executin8 of events such as the Humber Science Festival and the Northern Ireland Festival fostering community interaction and awareness. Provided valuable insights to shape the HDR UK 2024-2028 Draft PPIE Strate through collaborative efforts with internal and external stakeholders, ensuring inclusivity an(1 accessibilrty in public consultaiion processes. Contributed significantly to advancing the mission of the Public En ement in Data Research Initiative IPEDRII by helping with the planning. analysis, and re ort for the survey consultation on the Draft Best Practice Standard for Public Involvement and En ement. Provided constructive feedback on the PEDRI business plan for its second phase, shaping its direction and influencing the creation of pled8es to foster unified commitment to public involvement and engagement among all participating partners. Played an integral role in the plannin8 of the Alliance-PEDRI event aimed at explorirb8 Potential barrier5 and facilitators to the adoption of the draft standards earlier mentioned. Demonstrated dedication to Health Data Research UK'S commiiment to the Sha￿d Commitment to Public Invofvement initiative by active participation in related working groups and dissemination of k milestone5. Actively engaged in the PPIE award initiative by contritwjting to the selection process. evaluating submissions. and rovi(lin valuable ins hts. Co-designed a Diabetes Data Science Cata st and CVD-COVID-U IMPACT A roval and Over51 ht Board tase study highlighting the importance of public involvement in call for funding and research application panel5. Co-developed public communication outputs sharing the findings from the Centres work across Im mart hones and Wearable ensuring that the outputs were accessible and understandable. In Co-developed a Short film showcasing the Importan￿ of public invofvement within healih data research and across the BHF Data Science Centres work,. io HEALTH DATA RESEARCH UK TRUSTEES, REPORT FOR THE YEAR ENDED 31 MARCH 2024 Co-desi8ned a new atient and ublic involvement website section on the BHF Data Science Centres new website launched in August 2023 Co-authored publications about Smart hone5 and Wearables Data in Cardiovascular Research. Reviewed and provided approval for applications within our VID IMPACT Consortium Co-presented at BHF DSC Monthly webinars with a focus on plain English and its importance from a public perspective. Reviewed the DARE UK pyogramme proposal and delivery strategy to ensure strong focus on Public Involvement and Engagement IPIEI and alignment with public benefit objettNes. Attended quarterly meetings to deliberate on specrfic DARE UK PIE plans. activities. and challenges. offering guidance as needed. Collaboraled as 'Lay Leads, within DARE UK-funded projects delivery teams to facilitate and oversee the integration of PIE aspects into project delivery. Provided guidance for the evaluation of the PIE activrties and outcomes within the DARE UK S Pro ects and Oriver Pro rint Exem lar Informed the design of a public-friendly information pack explaining DARE UK'S federated architecture blueprint in clear terms for public understanding. Co-governed the design and delivery of a scientific use cases workshops and reports. explorin8 on research opportunities and challenges al￿ne￿ with the DARE UK vision. Advised on the conceptualisation and design of a new DARE UK brand identity and website to improve clarity of purpose and accessibtlily. Co-planned, attended. and contributed to variou5 DARE UK online and in-person events. including projert showcases. community group events, and rewrt playback and review sessions. li HEALTH DATA RESEARCH UK TRUSTEES, REPORT FOR THE YEAR ENDED 31 MARCH 2024 Plans for future periods April 2024 will mark the start of Health Data Research UK'5 second year of r(s second qurnovennial cycle, with our core funders - nine of the largest government and charity research funders in the UK - havin8 awarded u5 £71.3 million for the years 2023 to 2028. While the institute's long-terrn vision for large Scale data and advanced ana1￿1c5 to benefit every patient interaction. clinical trial and biomedical discovery and to enhance public health remain5 unchanged. we will follow a refreshed plan to increase the speed, scale and quality of health data science and so enable new discoveries. In 2024125 we will align efforts around four. focused and tactically important objectNes. which will enhance integrated delivery of existing programmes l. Accelerate access to large-scale data- by"getting the basics righf Support implementation of Unifying Health Dats Review to improve UK-wide data access and data availability Work in partnership with the NHS England Data for R&D programme to delNer single front door to SDE network Demonstrate the potential of OMOP Common Data Model as arh enabler of efficient cros5-re8ionln8tion research studies 2. Accelèrate delivery of impatt to the NHS. patients and the public across the UK Ensuring that research data insight5 generated across the institute, respond and inform UK-wide health policy needs as rapidly as possible 3. Push the boundaries of Equality. 04¥ersity and Indu5ion Ensure flagship activities such as the Black Internship Programme scale effectivelv Ensure current EDI artivitie5 across the Instituie lincluding data dNersityl align for greater impact 4. Connert instituie healih reseawchers and Infrastructuwe developer5 to deliver useru￿)atioff Oara S(￿￿e CenrrE Data & ConnettNiry Nar1(￿1 Ctye Study". Phaseo 19 83 349 1.579 281 15 &481 16821 160 7,774 Total ft*striCted ii.w) 27.2 113.8991 13 25.389 Tot•1 olfu 31.9 85.611 86.OS3 45 HEALTH DATA RESEARCH UK NOTES TO THE FINANCIAL STATEMENTS FOR YEAR ENOED 31 MARCH 2024 11. ANALYSIS OF NET ASSETS BETWEEN FUNDS Analysls of net funds- C￿lieNt year Unrestricted Funds 2024 strirted Funds 2024 Total Funds 2024 £'ooo Intangible fixed as5et5 Tangible fixed assets Current assets Creditors due within one year 34 167 57.515 12.0191 12 46 167 83.720 14,1961 26.205 12.1771 Total of funds 55.697 24.040 79.737 Analysis of net funds- prior year Unfesirirted Fund5 2023 Restritted Fund5 2023 Total Fund5 2023 Intangible lixed assets Tangible h"¥ed assets Current a5set5 Creditor5 due within one year 50 90 95.367 19.4541 67.029 16.5061 28.338 12.9491 Total of funds 25.389 86.053 12. RECONCILIATIONOF NET MOVEMENTIN FUND5TO NET CASH FLOW FROM OPERATING ACTIVITIES 2024 2023 Nei income for the year las per Statement of Finanaal Activities) 16.3161 54.072 Adjustment for: Depreciation and amortisalion tharges Di5P05a15 Net bank interest Decrease / lincreasel in tlebtors IDecreasel/lncrease in creditors 67 12 1221 I2.￿)3 15.2581 69 41 154.047 16.S571 Net cash provided by operatin8 adi¥ities 16.4251 46 HEALTH DATA RESEARCH UK NOTES TO THE FINANCIAL STATEMENTS FOR YEAR ENDED 31 MARCH 2024 13. ANALYSIS OF CASH AND CASH EQUIVALENTS 2024 £'o 2023 Cash at bank and in hand ,502 8.146 8.502 .146 14. OPEPATING LEASE COMMITMEl¥fS At 31 March the total of the Companvs future rninimum lease payments under non-cancellable operatin8 leases was.. 2024 1023 £'ty)o Amounts payable- In less than l year In two to five years Total Is. RELATED PARTY TRANSACTIONS In the course of the year 2024. Health Data Research UK received grants of £17,717k12023.. £25,195kl frorn The Medical Re5Earch Council (part of UK Research and Innovationl. £71YJk was owed to Health Data Research UK at 31 March 202412023.. £345kl. UK Research and Innovation IVKRII 15 a founding member of the Company. c￿er the course of the year the organisation received 8rants 01 £885k 12023.. £795kl and incurred no other expenditure12023.. £153kl in relation to Wellwme Trust. Wellcome Trust provides funding 8rants to the company diiettly for the Health Oata Research UK Turing Wellcome PFIO Programme in Health Data science, through UKRI as a core funder and through the Covid-19 Therapeutic5 Accelerator. Health Data Research UK is also a Tenant of the Wellcome trust Durin8 the year the or8anisabon received grants of £ICXJk12023= £2CthI Irom Swansea University ènd incurred no expenditure12023.. £3.149kl as grants payable and £132k12023.. £341kl as otherexpertditure_ Health Data Research LIK owed £20k as at 31 March 2024. Cathie Sudlow. Chief Scieniist. Deputy Oirettor of Health Data Research UK and Director of the 8HF Data Science Centre. is Chair of the Strategic Advisory Board, DATAMINO at the Swansea University and partners_ er the financial year. Health Data Research UK recer¥ed non-grant income of £15k12023.. nill and incurred no expenditure12023.. £1.156kl a5 grants payable towards lrnperial Colle8e London. Mark Walport. a member of the trustee boaré. is Honorary Distinguished Professor ol Medicine at Imperial College, London, and Chair of the lrnperi31 College Academic Health Sciences Centre Partnership Board. During the year the or8anisation incurred £21k12023-. £3kl as grants payable towards Manchester University NHS Trust. £1Sk was owed at 31 March 2024. William 8oa. a member of the trustee board. is Sirategic Finantial Advisor to the Manchester Uni¥er5ity NHSTru5t. Throughout the year the organisation incurred no grant payable expenditure 12023.. £1,284kl to the Scottish government. Andrew Morris. Direttor of Health Data Research UK. is Chair of The kottish Government COVIO-19 CMO advisory Group and Chair of the Scottish Government Stsnding Committee on Pandemics. During the year the organisation incurred expenditure of £477k12023.. £3,148kl as grants pèyable artd £116k as other expenditure to the University of Edinburgh. Health Dats Research UK owed £311k12023.. £105kl at 31 March 47 HEALTH DATA RESEARCH UK NOTES TO THE FINANCIAL STATEMENTS FOR YEAR ENDED 31 MARCH 2024 2024. Andrew Morris, the Director of Health Data Research UK, is Vice Principal and Professor of Medicine at the University ol Edinburgh. Graham Spittle. Chair of the 8oartl of Trustees until July 2023. 15 Dean of Innovation at the UnNer5ity ol Edinburgh. During the year the or8anisation incurred expenditure of £245k towards NHS England. Mark WalporL a member ol the trustee board. is a non-executive director of NHS En8land. During the year, the organisation inturred zero expenditure 12023. £7801 io Thrive Worldwide UK Ltd. Alison Hopkinson. fomer Chief Operatin8 Officer and Direttor of Delivery (in post until April 20231. is the spouse of the Director and Shareholder Thrive Worldwide UK Ltd. During the year. Dr Graham Spithe. a Trustee. was paid £5k12023-. £16kl for hi5 Servi￿ a5 Chair. Durin8 the year. trvstees were reimbursed expenses amounting to £2k12022". £lkl. 16. COMPARATIVE STATEMENT OF FINANCIAi ACTIVITIES INCIUDING INCOME AND EXPENDITURE ACCOUNT- Prior Year Unrtstrirted Funds Restrirted Funds Total 2023 £'ooo Income from: Donatiofts Investment5 Other income 58.327 27.292 85.619 Toial Income 58.828 27.295 85.623 Ejtpenditvre on: Charitable activities Research 17.6SI 13.899 31,550 Total Expenditure 17.651 13.899 31.550 frjet incornellexpenditurel bth>re transfefs 40.677 13.396 54.073 Transfefs beTh¥een FU￿d5 li 1131 13 Net movement in lunds 13,409 54,073 Reconciliation of funds Total lunds brought forward 20,OLKI 11.980 31.980 Total funds carried forward 60.664 25.389 86.053 48