Rb:Glb'l'KRkD CIIARII'Y NUMBLR: 1191179
Farri¢s Kirk & M¢V¢an
Hcathhall
DIJMfKILSSIIIRL
DGI 3SJ

for thé YoAr Endtd 31st Jul 2025
1>gge
Repor* of th• Tru$¢¢¢s
Indgp¢nd¢llt ExAmillcr'J Report
StAt¢mEfbt Dr Fin￿n¢lA1 Actlvltles
Sheot
Notes to the Finllncial Statements
Det•ll¢rt StAt¢m¢nt of iiln#oel41 Actlvltlos
io

rt of the Tyustees
ror tlie Year En(led 31st Jul 2025
Thc Irustecs pr￿rnI ilicir report with th¢ fiiiaiicial sla¢em¢nts of Ilie chariLy for the yeai. ended 3151 July 202$. Thc IrusicL.I have
dopted thc provisions of Argounling and Rcporting by ChgritiC5.' Sialctncnl of Rccomrncnd¢d Pravlicl Appli¢8bl¢ io ¢hurili¢s
preparing ihttlr ttctout)1s In accordllnLe wilh the Finonci&l Reporting Slandard ttpplieable in the UK and Republic Qr Ir¢laiid (FR%
1021 Icrrcclivc l January 2019}.
OBJkC1'1VES ANI) ACTIVITIES
ObjtctivtB fLnd 91ms
Th¢ ubj¢¢iiv¢b ofihc CIO are thc r£liefofsickiiess and the pi'eservaiion of Iiclllth. in particular bul not cxclusively by-.
la) Iljc rcliofind tre4im¢nl of pcuplc wilh Spinal Mu5Gular Airophyy
Ibl Ilic promotion ￿ld support of rcsettrLh inlo Ihc Cause. Irculment #Ad possibl¢ pr¢v¢niioii of Spiii&l Muscular Atrophy ond the
publi¢aiior) and dis5eminaiion ef tl)at rc%carch for ilie public bellcfit., and
(¢1 Ihe odvonccinont ofih¢ ¢du¢uilon ofihc g¢n¢ial publi¢ in Spinal Musrular Atrophy.
Public benefit
Launch uf w¢b5il¥ and donation rncch4nis
Ilegul￿ social Media ¢iigag¢menl
Variou¥ cv¢nlb aciivilies io raise funds, .e.8. charity walk. coffcc mornin8& painiiJtB auction
-rh¢ firsi &¢livity the charity l5 SUPPQrtin8 ix clinical rcscarch wilh rcgRrd5 Ihc objc¢livc ofthr EhaFiIy
ACIIIF.Vb MF,NTS AND PF.RFORMANCE
CliaritAblt ACtivlti¢$
As Iw51ces ofACE SMA, wc Thrc pleased to present the annuol rcport and finuncial 5totemcn15 foi Ihe ycaT crJd¢d 2023. This r¢pori
providcs an ovcrvicw ofihc chariLYs &c￿Ville$, achievcments. flnanci￿ pcrformancc, and fulurc plLn5.
Thc charity'5 purpo.%c is ID huild an Aivfftreiiess, h¢lp fiiiid a ¢ur¢ olld help iiiiplciiicnl cxcrci%c aiid pliy510thcrapy for rhildTcn wid)
SMA. ThL tru51LL5 have mttd¢ signiflcant pi'ogresy low￿.d5 achicvittg Ihcsc objectivc8 ovcr Ihc pa51 ycar wilh Ili¢ conliiiue(I foius on
rundi118 tlie ACI:. 8MA pliysioiliLrApy Llinical trial lviih Tli¢ Univ¢rsiiy ofoxford, lli¢ Iii8lilight% of illi3 aciivity have bccn-
Rcctuit 14 participDnt% for the ALI.: SMA phy.8ioiherupy I rial
All fainiliLs involvcd havc participaicd cnihusi851i¢dly and thttre h&ve bccn xcro dropoutb despite itt¢ r¢laiiv¢5y h¢ovy
coniiiiitment iiivolvcd
All futniliu huvc 5igncd up to ihc 6 tnonth extcnsion of thc trial thlli ACE SMA ho5 providcd Rdditionul fiindinR for
Th¢ irial aAd its ¥xlensiOn Wtll provid¢ improvi longitLidinttl dilla Io suppori ll rnorc sigiiifi¢niil roll oJt ofthe project 10 furihcr
cenirc% in tlic IJK. Grnni funding opportiiiiities are b¢i118 ¢xplored 10 support a Inu¢h larg¢r l)h&i£ 2 pi'ojcci.
Th¢ ¢h&rtty ¢onllnu¢s ID cngagc with the SMA CDnimunity lo cxplorc furthcT arcn5 in which thr choTlty ¢ould bupport tn ih¢ fuiiir¢,
INANLIAI. RfVIEW
Fln•D¢lAI posltlon
Tlic Charliy iai5cs funds to m¢el IL% c011511tulional objectives aiid tlie pr￿crvQt1on of li¢alth. DurSng th¢ p¢riod of th15 I￿ort th¢
Cliurity Iii¢iirr¢d M detl¢ll of£16,763 (2024 - £137,981) from 115 actlvltlcs artd at lh¥ ¥nd of lh¢ period lh¢ Cliarity had ioial r¢%erv¢8
of £20,43912024. £37.202). all of which is uiir¢stri¢tcd.
Expenditure.. The ¢li&rlly htts m#inl8incd rt focu5 on ¢nsuiinE thai ¢Xp¢ndiI￿￿ all￿5 wilh i15 charilable oblecilves.
Prineipil fyndlng 50ur¢¢g
Th¢ charilgs sn¢onJc is primarily dcrived froin donations ond fundrailiiig events. Notably. it rcceivcd significant fundiug ftorn &
lllrke Plirty in M&y 2024, whicl) cnabled It to fund ihe extenslon of the study.
RLY¢rv¢i poll¢y
ACE SMA has a pollcy ofkeeping sufficient rLs¢rves lo support It5 ongoing aciivily for a¢ l¢osi ooe ytrtr.
IIUTURE PLANS
Looklng forword. lh¢ churily aitns 10 build on thc suGc¢s¥C5 oftli¥ pllsi y¢ur dnd foGus on lh¢ following key oroos..
Aidin8 Thc Ilniveriiiy of Oxford iii srcuriiis ￿￿nIs for Ihe lurger Pliose 2 irial
Und¢riak¢ g ¥rLdlLr nunibcr of smallei. fuiid raisin8 activities insleod of focu%in8 011 onc lar8c fund raising party
t3uild Ihore Awur¥n¢s5 for SMA ihrough rcgulHT tncdia opportunilic5 and Ivh¢J) thcy uri5¢
4 Pind an aiiibailador lor ACE SMA In a wlieLlchJir llihlet¢.
W¢ ar¢ comjniltcd lo huildi1i8 AwaEne53. h¢lp fuiidiiig n ¢ur¢ uiid impoiionily inipleincniin8 exerci%c and physioihcr&py for childrcn
with SMA and will ¢onlinu¢ working with our 5UPPQrtcrs, bcncliciarir5, und partncib lo furthcr OUT Itnpii¥l,
STItUCTURE. GOVERNATr4CEAND MANAGEMENT
Governing docuinent
Th¢ cliarity is ¢onimllcd by It% gtsvemiiig documeiil, & deed oftru51 ond conslilules uniiicorporthd Ghariry.
R¢¢rwltm¢nt And appointment of new trustees
I'rust¢¢s hove be¢rt re¢ruii¢d by th¢ foundeis ol Ihc ch4Lrity. Therc is an annud5 TfVi¥iV prtr¥¥ss in Iln¥ wilh ¢h¢ wnsiilulion.
Puge I

r Eindod31st.lu
REFERENCE AND ADMINISTRATIVE DE'I'AILS
R¢gistrr¢d Charity number
Principnl llddress
Gl¢b¢ Coii&g¢
Suitoii Mand¢ville
Salisbury
SP3 SNA
TruJt¢¢J
M l.lowe5 C11ainnan
Mr5 C A E O'Hora
Mrs A Fl Wheailcy-Hubbard
MTh S l.lowes
Ms R 11 CiUttSI
O C L William¥
Independent Exomintr
David Miicliell, CA
rartl¥s Kirk & Mcvcan
Durtifrl¢s lirJtei'pris¢ Pork
DumFri¥s
OUMI".RILS%I.IIIiE
DGI 3SJ
Approved by order ofuie bogrd oftrusi¢¢s on 5th Jthnuury 2026 ind si8nod on Its behalf by..
M [10￿.0.￿- Trus
Pa8e 2

r'5 Re
Independent eximlnir'j r¢por¢ to tho trust¢¢J ofAC& SMA
I report lo the thorlty truS￿eS on my oxaminatlon of the accounts ofACE SMA (tho Trust) for thc year endcd 3151 July 2025.
R¢5PDll5ibili¢i¢5 and b451¥ of report
As Ihe charlty ¢rusLe¢.¢ ol'tlio Trust yoy ar¢ respon$ible for ilic preparatlon of lh¢ oc¢ounts ltt accordancc with Ihc rcquircm¢nts' of Ihe
Ch81'itic& Acl 2011 ('thc Act).
I report In respect of my exwhinAtioii of tho 'fru$t's a¢¢out)ts t#rrl¢d out under Stctlon 145 of thc Aci in c&rrying oul my
exaniinaiion I havc followcd all applicabl£ Dircclion5 8ivcn by Ili¢ Charily Cornmlssion under Se¢iion 14515llbl of the Au.
IndopoNdint eximln¢r's itllemtnt
I hdvc complctcd my cxami118Lion. I coiifjrm 1112L no n)ateriai rnaiicrs have comc lo rny ultcntion in ¢onn¢¢¢ion willi Ilie cxwnin)iion
giving ni¢ ¢aus¢ 10 b¥licwe thai in any matcrial resp¢¢i'.
accollnlin8 rccord5 wcre not kept In rcspecL of thc Trust as rcquircd by Scclion 130 ofthe A¢i,' or
Ilic a¢¢ounts do noi t)¢Lord wilh thobb records., or
Ihc uc¢ouiiLs do nol comply wilh the gpplicable requirement5 cots¢¢ming th¢ form wid ¢ODt¢ni of #¢¢ounl¥ 5¢L out in th
Churitics IAceounLS and Reports) IlcBul2tions 2008 oth¢i' Ui&n any rcquircmcnl Ihal th¢ aiiouiiis giv¢ a Irue And fair vicw
wliieli is iiot li moii¥r ¢onsid¢r¢d lls p&wI ofAn ind¢p¢iiiJ¢nt ¢xami11o1inn.
I hov¥ no con¢¥rns and hAv¢ cvmtt across no olli¥r muii¢fb in ¢onii¢¢iioii willi tli¢ ¢xarninoilon to whicli atlcntion should bc drown in
Ihi% iTport in ordcr 10 enable L prop¢r uiidersigiidin8 of Ihc aceoun15 10 bc rcaclicd.
D)vid Mii¢liell. LIA. CA
FaLT1¥5 Klrk & Mcvcan
l)umfric5 llnterprisc l)srk
14¢oihh411
Duinlrics
DIIMFRIESSI-IIRI:.
DGI 351
5th January 2026
Po8¢ 3

Stntement of Firtnncinl Activitie5
for the YeAr Féndcd 31st Jul 2025
2025
Unrc51riclcd
rund
2024
Total
nds
No*s
INCOME AND ENDOWMENTS fiROP¥l
Doll￿tionS and le8￿41¢5
33,190
5,680
Oih¢r Iradlng aeiivitics
ltsv¢stment lrtcoine
44,331
220
8,496
Totgl
77.741
XPLNDITURE ON
Rlising fund¥
24.438
174
ChAritgblt nctivitie$
ACC SMA
70,633
152,798
To¢il
95.071
152,972
NET INCOMLllkXPETr4DITUREI
117.3301
(137,981)
RECONCILIATION OF FUNDS
Total funds biou8lit forward
37,202
175,183
TOTAL FUNDS CARRIED FORWARD
19.872
37,202
Thc nolcs forjn part of Ihcsc financial 51atctncnt5
Pa8¢ 4

Balnnce Sheet
31st JUS 2025
2025
Unro51ricted
I￿nd
2024
fund
NoiE5
CURRENT ASSETS
D¢biors
Prepaymcnts and accrucd incom¢
Lash ui bink
126
573
2.340
33,249
20,196
20,322
38,162
CRFDITORS
Amounis Folling due wiihin oiie year
14501
(960)
NET CURRENT ASSETS
19,872
37,202
TOTAL ASSETS LESS CURRENT LIABILIT114S
19,872
37,202
NET ASSETS
19,872
37,202
FUNDS
UnTCgtriclcd fund
19.872
37,21)2
TOTAL VUNDS
19,872
37,202
Thc financial SLileiKents were approved by the 13oard of Trusi¢e5 and Authori.%ed (or issue on 5th January 2026 and iverr si8ncd on its
bchaifby..
M FIoiYe5-'frusree
The notes fomi pRrt of thow finmeiol stslt¢moiiLq
P#ge S

Notes to tlle Finnrttiml StMtsmtntS
foi. tlie Yenr Endcd 31st Jul 202.1
ACCOUNTING POLICIKS
Ilijli of prop#rrng the fJnllnciAI Jtitement5
'rh¢ finJn¢ial sLAtements of ihc Ch￿ritY, wliich is o public beneni enlity undor fRS 102, hovc be¢rt preparod in accordance
with ilic Chariiics SORP Ib'R8 102}'Accouiiiin8 and Reportin8 by Chariiic.i'. StalLiiicni of RccoinmLnded Pracii¢L uppliciibl¢
10 ¢hariliL¥ pr¥paTill¥ thcir &ccounls in akcordancc with Ilic financlal Reporting Siandard appli¢able in tlie IIK ond Rcpublic
tsf Ireland IFRS 1021 leffectiv¢ l January 20191,, 1'.inaticifjl Reponing Siaiidwd 102 'Tlit Financial Reportittg sL￿dard
pplicablc in ihe UK and Jiepubli¢ of Ir¢ltsnd' and th¢ Ch￿111¢5 Act 2011. Thc fiiianttial statcmcn15 liavc bcen prLp8rcd under
lh¢ Iiislo¥i¢&l cost convcnlion.
Incom¢
All inLornc is rcccsnised in tlic Slaleincni of l.'inancial Aciiviiics oncc thc cliarily has cnliilcrnrnl to lh¢ ￿n￿8, il 1$ probabl¢
that Ilio income will b¢ r¢c¢iv¢d Ind lh¢ ￿mount ¢iin b¢ meJsiir¢d r¢liubly.
Expenditure
LiNbili11¢5 Ure Ircogniscd cxpcnditurc a5 500n a5 Ihcrc 13 a Icgul or conslTU¢iiV¢ obligaiion cDinmitiin8 Ilic cliariiy to that
expeiiditur¢, it is prob&ble Ihai ￿ IrJnsf¢r of economic benclils wlll be requir¢d ill SeLileiDciit and thc amouni of thc obligation
can bc measured rcliahly. l.:Kpciidilurc is accouiiled for on an acci'uals basi5 and hgs brrn ¢l&bsifi¢d linder headings Ih&i
g8r¢gJt¢ all rclalcd lo Ihc c&tcgory. Whcrc cos15 cgnnol bc diireily tttlribut¢d to partic￿1￿1 h¢lldings they li&ve b¢¢n
allocaitd 10 octivilits on a basis con5isILnt with the use ofresoiirces.
(yranis olf¢r¢d subj¢ci lo condilion5 which havc not bccn m¢1 ai ihc y¢ur ¢nd dAl¢ ar¢ nol¢d as o ¢oinmi(mcnt but not accrucd
as cxpenditure.
Tix*tiDn
I'he Chorlty 15 ¢x¢inpl from I￿X on Ils ¢haril&bl¢ N¥liviti¢%
Fund Ac¢ountlng
Uni¥siTirlcd fulld5 can bc used In oecoTdance wsih tlie chwitable objcctlvcs al thc disrr¢tlr>n ofih¢ ¢ru31ce5.
5PCCTficd by tlie donor or ivlieii fundg arc roiscd for paniculur rc5trielcd purpo%cs.
rurth¢i ¢xplunation ofihe nalurc purposc ofrach fund is in¢Sud¥d in the not¢s io tlie finaiicial staicmcnts.
OTHER TRADING ACTIVJ'I'KES
2025
2024
Fundraising ¢vttntS
44,331
8,496
INVESTMEIYT INCOME
2025
202A
Dcpoyit ￿coUl71 inter&st
220
815
TRUSTEE5' REMUNERATION AND BENEFITS
There wcrc no trustees, remuneration or otlicr bcncfits for thc ycar cndcd 315t July 2025 nor for Ihe year ¢iid¢d
31.%t July 2024,
'frus¢¢ts' ¢xp¢rt$os
Th¢re w¢r¢ no Irust¢¢¥' CXPCll5¢5 pDid for thc Y¢￿ ￿dEd 3151 July 2025 nor for lh¢ y¢&r ¥nd¥d 315l July 2024.
Pag¢ 6
oonlinued..

NotQS to the FinAnti*l StAttmtnt
for the Year Endcd 315t
COMPARA TIVES FOR TIIE STATEMENT OF FINANCIAL ACTIVITIES
Unresiricicd
rvnd
INCOME AND ENDOWMENTS FROM
Donaiioii¥ and l¢¥a¢iL¥
5.680
Oihcr tradin8 activilies
Inv¢siin¢nt in¢Dmc
11.496
Total
14,991
EXPENDITURE ON
ai.gin8 fvnds
174
Charltllblo actlvltles
ACE 8MA
152.798
TotDI
132.972
NKT INCOMFIIEXPENDITURL)
1137,981)
RECONCILIATION OTr FUNDS
'I'otal fui)d% brouglit forward
175,18J
TOTAL FUIYDS CARRIED FORWARD
37,202
DLBI'OIIS: AMOUNTS VALLINC DIIK WITIIIN ONK YXAR
2025
2024
VAT
126
573
CREDITORS.. AMOUNTS FALLING Dub WITIIIN ONE YEAR
2025
2024
Oih¢T crcditDrs
450
960
MOVEMLN'f IN FUNDS
N¢t
mov¢meiii
in fund5
At
31.7.25
Ai l.8,24
Uijvostrlctod fuKds
Gcneral fund
37,202
117,3301
19,872
TOTAL TrUNDS
37,202
117,3301
19,872
P#g¢ 7
¢onlinued..

ACESMA
MOVEMENT IN FUNDS- continued
Ncl movcmenl in fund4 includ¢d i# Il)¢ abov¢ Ar¢ as follows..
Inoom5ng
r¢sour¢e.q
R¢>oiirL¢Y
expeiided
Mov¢m¢nt
Unrtstrlttod fund$
Gcncral fund
77,741
195,0711
117,330)
TOTAL WUPIDS
77.741
195.0711
117,3301
Comp4rRtlv¢s for movoni¢nt in fund5
N¢t
mov¥inent
in fund3
At
31.7.24
Al 1.8.23
Unrestrlcted fvnds
G¢n¢rnl fund
175,183
1137,9811
37,202
TOTAL FUNDS
175,183
1137.9811
37,202
Coinporoiive rtei movemrnl in fund5. includcd in the abuvc arc as follows..
Incoming
rewiiries
Re50urcc5
¢xp¢iid¢d
Movemcnl
Unrestrltted furtdy
Cieii¢rg1 fund
14.991
(152,972}
1137,9811
TOTAL FUNDS
1152,9721
1137,9811
A currcnl ycar 12 moiilhs and prior y¢ar 12 Inonths ¢omblncd posiiion is as ftsllows..
Nel
moveiiient
in funds
At
31.7.25
Ai 1.8.23
Unrestricted funds
OEncral fund
175.183
19,872
TOTAL FUNDS
175,183
19.$72
A current year 12 moiiihs ￿Thd priur yellr 12 month5 combined nei mov¢mertl in fund¥ Included in Ilie abov¢ nre os follows..
Incotning
Tcboufc¢5
Rc¥oiiri¢s
¢xp¢nd¢d
Mov¥m¢HI
Unrr5tri¢led funds
GenLrul funtl
92.732
1248.0431
TOTAL IfuNDS
92,732
1248,0431
Page B

t(k thts FingnciAI StntomEnts- co
for the YtAr Elldtd 31st Jlll 202S
RFLATCI D PARTY DISCLOSURES
Therc werc no rclatcd party tsw)saciions for tile year ended 31s1 July 2025.
Pllsc 9

Detnlled Sthtement of Finll
for the YEnr End d Jlst Jul 202S
2025
2024
INCOME AND ENDOWMENTS
Donatltsns And IcgAeloJ
Donation5
33,190
5.68
Other tr4dlng A¢t5vitieJ
Fundr￿$1￿8 tvent%
44.331
8.496
Investment Irseomo
DLposii a¢couni int¢rest
220
815
To¢41 In￿mIng rwourrts
77,741
EXPENDITURE
RM151n£ doDntlQll$ And IEgwei¢5
Sundri¢s
Evcnl c051s
174
24.438
24,431
174
Charitable nctivitiP5
300
292
66
Advcrtisin8
Sundric5
Web5il¢ CeSI
ciivin8.com f¢¢
Givcrgy
Granis ¢0 ih51ilUliunb
555
50d
209
315
1,395
150.000
68,597
70,165
152,284
Support eo$ts
Bank ch8r8CS
18
34
Govorn#nEo rojts
A¢¢ounioncy feeb
450
480
Total r¢3ouw¢s ¢xp¢nd¢d
95.071
152,972
Net exptnditure
117,3301
1137,9811
This p88c dDes not form part of th¢ $toiutory fingn¢i41 statements
PAg¢ 10