KW
Unaudited Financial Statements
Isla Rose Foundation
Forthe year ended 31 January 2024
Prepared by x1rl￿K0d Wttson Lbmlted

KW
Contents
Tntstees Report
Trnstees
IntlependentExaminerf5 Report
In¢ome&EypenditureA(count
Balance Sheet
P4112¢¢8

KW
Trustees Report
Isla Rose Foundation
Forthe yearended 31 January 2024
Isla Rose FoUndatSon-Yeartyu￿la1e(Io24}
M•kiry• DiffereTrteT￿ethe1
We'réthrilled tosharethe Isia Rose Foundatlon'$¥hlv*wnentsthisyeart
K•ykhI•v￿￿ntslTr2Q2&.
FundkngR•s•arth. We maJeasignifiCant￿ntrib￿10n of£3￿}10 supportvital NKH research atVCI London.
SupportiTri Famili*:Wedirertiy impacted ajwngyrt's bfe tyfundingthree monthsof specialised therapyforsoffa,
battllngNKH.
F¥ndrnisin¥Sucus5:
Despite a challenging eronDmic dlrnate.theSwthF￿CornMUlYtyar￿ wpportws beYOr￿ have rallled behirrfl u5. We*e
successfully rai5edlund5through IrKal and natlonal pre55co¥erage.alongsTrdeheartwamiin8community lundraisingevents.
Ral4n¢A￿reMU.
Sodal media continvesto be a powwlultr*)L Byshartng our joumey, ¥R'Ve￿8n1fiCant￿inCw¢ased awar¢ne55 of NKH'S rarityand
8amered imialu4blesUPPtytfromthe*idercommunity.
Ourwslon:
A cure for NKH remains oyrultirnate goaL
We'll conty"nueto empower NKH famlliesfy proYfdlngatte55toequipmentand theTrpies not readityavaiiablethroughthe
NHS. uhlmatelyimprovingthelrquabtyof ble.
Gene therapy research U￿ng mice rnodels 15 dernon5tratinR￿%nIficant advancements, ofterfnga gilmmerof Wefgr Improved
treatrnentol Non-KetotK trtyper8lycrnemia INKFII. This approach holds excitirEpotential for.
InwUt•r• Trn•trn•nt Early intewvention ￿ crucial. and ge￿therapY offerstherA)ssiknirtyoftreatlng NKH before birt
potentially preventingthe severe complicationsofteTh a550Ck?ted wrth the disease.
Extsnd¢d Llftspan%Currenttreatments managesyThptomsbutare Thot curatNe. Genetherapy hasthepotentialto
addresStheundor￿ngBenet1( causeTr polentialty leadingto a significant improvement in ￿fe$Pan aThd o¥eTall we114>eing
lor NKH patiffit&
WINle research is still in pIL￿[In1£31 Stage4s￿d￿ in mice mode15have proThusingrewtts:
In¢r•asedActl¥lty of th• Fwhrllon•lEnzyme: Genetheropysucce55fuilyrntroducesa hea￿hY copy of the affected ge￿.
leading to the productim ofthe functionalenzyme respM&blÈ Forgtycine brÈakd¢>wn.Thi% diredy addressesthe core
$5ue In NKH.
ft•du¢•dGl￿1Th•L•ve1￿. Studies reporta &gnificarbtdecrease In8lyclnelweLs w)treaied mice, iDdlcatyngthe potentialto
control thetOKiC buildup associated wrth thedisease.
Impm¥•d N•Jrologi(•lFunrtion: Earty inter¥eniionthrouKh in4JteroEenetherapyhasshown prnm￿e in theory ol
preVentingtheSe￿re neurolrycal cornplicationsoften seen in NKH patrents.
whilefundralslngrema1nscompe￿1￿4￿tsr￿aUthlrf$stOryhas8ar￿¥ed Significant lrfaland national media attenikn, raising
a￿arer￿sS and ￿ltal￿NI% Inthe fMj￿,we ￿aTrt0 rEAtequipmenttotherapycentwes, wlth yoceed5 benefftingtheltsundat￿n.
OpporbJnitiesYouTubethannelorincreasin8aw*enessof socwl media page&
UrthudthdKnanth1Slateme￿ Isk RoseFty*thtio
PaKe34ro

KW
OurFivtthye¥ G••ls."
Secure rna¥imurn lundingto find acureforNKH.
EmpowerNKH familieswth 8r3ntsfortherapy.eqUiprr•iL4ndessential￿ppDrl
Increase research fundingat UCL
Look intoopeninga bcal charityshoplpop upshoptrlaltl) potentsaltybringin c0nstantfundingsupportwlt￿)utSett1nl
up actual event&
V•lu•s Ind C•liabontio
Collaboration i5at the heart ofowsuccesswevalw.
Cornmunity 5UPPOrtand invO￿ement fundrdi%inginiuati¥e&
Seeklngprofe55ional freeKuidarKeto refineourEoaLs and ¥eseaffh effort*
ContiThuous learning and acommitmentto progres
Supportingeveryoneattected byNKH-familie& ￿$￿arthe￿ arrtllurKlTri5e
WÈ tsperate a dedlcated teamolvolunteerswho are pass*)nate aboutourcause.
Flh•tKi•lSustain•biiity:
The ISLI Rose Foundation opeTrtes inde￿￿denttythr0l￿h ow**bsite. Ger￿{￿J$￿1￿nttÉrèCcOUIrtaThts manageouryearly
accounts.
Futsr• Plans:
Our board otlrustres ffleets quartertytoreviv* progress and stnteOraltypLin forthehJture. Weensure 04K actkins align wtn
ouitorevalue5and elfectNdy rnanage any risk&
We continue asa non profrtanddon'lcharge ewses.
LkniudwFlni￿ 5t*teir•*% ￿￿R&S•F￿￿dItsDTr

KW
Trustees
Isla Rose Foundation
For the yearended 31 January 2024
The trustees are re4)wbleforihè managementof therisksfated bythecharrty.
s.J. steel- Chair
S J, Camey-Trnstte
B•nk•rs
NatWe5t8ank PLC
130 Lord Street, Southport
PR9 QAE
Ind•p¢ndentEx•mln•r
I￿￿•¢1 Wilson ￿rnited
Unit2A.Swordfish Busit)essPart Burtough
L4Q8JW
Authoris
on beha1f01theTn￿ee5.
Slgned..
Poy5ofJ

KW
Independent Examiner's Report
Isla Rose Foundation
For the yearended 31 January 2024
IndependentExamlneVs R•porttoth*trustee*•ftheWa Ro*Fwnd•tkn
We reportonthÈ a¢¢ountsofthe Charityfortheyearended 31JarvJary2W44.whlch aye sLYOUtthi page$7and
Resp¢¢tl¥e r*sponsibilltiesvltru¥tW51nd •xarniner
The charivstrustees are￿ponsIbl¢fOTthe preparatfv)n oftheaccounts. The￿￿rity'strUStteseofisiderth4t an audlt Is not
required f¢Hihisyear tsndèrsectiofi 144121 oltheCharitiesAct2011 lthe2011Actl and that an independentexamination is
needed.
It isoUrresFor￿i￿lltyt0=
examinethe accounts undersectk)n 145ofthE 20LIA¢
. to foilowthe procethres laid dovth inthe8er*ral Direction5 given bythecharity Comm￿10n undersertion 14515llbl ofthe
2011 Act. and
.to statewhetherpartiCLtlar matters havecom*to our#ttention.
8*1sof Ind•p•ndont eufflin¢r's report
Our examination was(a￿led out in accordancewlth thegoneral DlrÈctkn5 yven bythe Charrtycommission. knexamination
Includu ? reviewofthe acwJntin8 reco*ds kept bythȢharttyand a comp0ri50n ofthe occouThts presented withthose records.
Itaiso includes Co￿lderatiOn of any unusualitemsordisdosures In the accounts, a￿15eeking explanationsfrom you astnJ5tees
conceming5uch matters. The procedures undertakendo Mt provideall the￿deThCe thatwouk4 be required in an audit and
corwvently no opinion isgNen astoWhethertheaccr￿nts £fft a'tnjeand fèirvie* ènd the reportis limited tothose matters
setout in thestatement ￿ltsw.
Ind•pMd•rf•xamln•rfs st•t*m•Nt
ITh corbnection withourexamination, no mattorha5come toourattention:
L whlch gives us reasonable causeto believethatin arymaierial re5pecttherequirementsto keepaccounting records In
accordance with section 130 of the2011ki' and to p￿Pare accountswith the accountiThg records and comply the
accounting requirementsofthe 2011P£t have noi betn Met or
I to which, in ouropinion. attention should bedrawn in onl@rto Q￿bIta proper urthr5tandingofthe accountsto be reached.
Inde￿ndent Ex•mlnqr
gned..
KirlAvood knmlted Urrit24 SwordifLSh Bu5rne55 Parl Lancashire.L408JW
PaEe6fjr1

KW
Income & Expenditure Account
Isla Rose Foundation
For the year ended 31 January 2024
Incom• and
(k)nafjvnsReceNed
enditureAccount
30.545
Thiapy&EquipmentE*p￿ses
Donation5 Made
110.X181
13,0001
17J36
TotallK•***ndEwthiurek£oi
Un•udM Fkn¥KblStattwrt5 lthlb)F•FtywbYoiirKb
PAy7of8

KW
Balance Sheet
Isla Rose Foundation
Asat31 January2024
33￿¢2011
Assets (liabilities
ASMtsi4ss curr•ntllabWti•5
Curr•Trtk￿j￿l
TotalAs5•ts i•sscurrnniDabMld
24,925
24,925
TotslAssetsiiiabllt
24?25
Ca itsl and reserves
T¢)tsl Pr•fft&L¢ss
rrentYeaTEamings
PmfitaDd IDssxcow)t
TotalT•tsi PYofit&Lo$5
I7￿6
24915
Toi*IGlWt•1￿drt$e￿S
24,925
Page8ofe