2023-12-31-accounts

DoGusign Envelope ID.. A1B3A320-1BC944D9-AEBD-AE2D6F204600 Charity Registration No. 1182637 {England and Wales) Charity Registration No. SC049948 (Scotlandl Company Registration No. CE016951 {England and Wales) THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP LEGAL AND ADMINISTRATIVE INFORMATION Trustees David Oxnam (Chair of Board of Trustees) Gayle Routledge Rachel Wilcox David Hobin Sarah Curtis Chief Executive Ashley Ball-Gamble Charity number 1182637 (England and Wales) SC049948 (Scotlandl Company numbèr CE016951 Operating name CCLG Principal address Century House 24 De Monrfort Street Leicester LE17GB Auditor Newby Caslleman LLP West Walk Building 110 Regent Road Leicester LE17LT Bankers HSBC Bank Pl¢ 2-6 Gallowtree Gate Leicester LE1 1DA Scottish Widows Bank PIC PO Box 12757 67 Morrison Street Edinburgh EH3 8YJ CAF Bank Ltd 25 Kings Avenue Kings Hill Kent ME194JQ

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP CONTENTS Page Trustees. report Independent audilorfs ￿port 11- 13 ststement of financial a¢livilies 14 Balan￿ sheet 15 Statement of cash flows 16 Notes to the financial slalements

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT FOR THE YEAR ENDED 31 DECEMBER 2023 The trustees of The Children's Cancer and Leukaemia Group are pleased to present their annual report and financial statements for the year ended 31 De￿rnber 2023. The financial statements have been prepared in accordance with the accounting policies set out in the notes to the accounts and comply with the charity's governing document, the Financial Reporting Standard applicable in the United Kingdom and Republic of Ireland {"FRS 1021, Accounting and Reporting by Charities.. the Statement of Recommended Practice for charities applying FRS 102120191, the Charities Act 2011, the Charities and Trustee Investment Iscotlandl Act 2005, and UK Generally Accepted Accounting Pracbce. OBJECTIVES AND ACTIVITIES The objectives of The child￿n'S Cancer and Leukaemia Group ICCLGI as defined in the constitution are.. For the public benefit. the relief of sickness and suffering of children. teenagers and young aduhs with cancer and advancement of education in the field of children, teenagers and young adults with cancer, in particular but not exclusively by.. 1. The relief of sickness and promotion and protection of good health by supporting research into the nature, causes, diagnosis, treatment and social consequences of cancer in children, teenagers and young adults, and lo publish the useful results of such research. 2. The relief of suffering of children, teenagers and young adults with cancer and their families and carers, through the provision of information and support services lo them. 3. The advancement of the education of the public in all areas relating lo cancer in children, teenagers and young adults. 4. The advancement of education and clinical practi￿ by the dissemination of knowledge of the latest research and best practi￿ amongst professionals and practitioners engaged in the treatment, care and support of children, teenagers and young adults with Can￿r. The main beneficiaries of the work carried out by the charity are children, teenagers and young adults with cancer and their families in the United Kingdom and elsewhere in the world. CCLG is the UK and Ireland's professional association forall those involved in the treatment, care and research of children and young people (aged 0-251 with cancer. Al the end of 2023, our membership had grown to more than 1,500 members. We also operate 'Teenagers and Young Adutts with Cancer, ITYACI, a specific membership group for those working with young people aged 13-25 with a cancer diagnosis, which had over 470 members al the end of the year. We support our professional members to network, share best practice, advance education, and our activities aim to ensure every child with cancer receives the best possible treatment and care, wherever they live. Vve carry out a wide range of activities to support our professional members, including.. Member interest groups, bringing together professionals working in the same professional group, or with shared clinical or research interests. to develop treatment and care guidelines, to deliver education. to initiate research projects and to develop ￿SoUrceS for use by other professionals. We deliver a range of meetings and educational events each year to ensure members are kept up to date with the latest developments in care, treatment and research. Our flagship annual meeting provides an opportunity for all of our members to network with colleagues from across the UK and Ireland, share best practice and leam about new innovations and initiatives. Professional voice for children, teenagers and young adults.. We advise govemments and other bodies and ensure that we are represented on important groups or in consultations, for example in the area of NHS commissioning of children's cancer services or the development of NICE quality standards and guidance. Our member website is a vital hub for professionals, providing a wealth of resources and educational opportunities, complemented by our new online member community, allowing networking and good practice sharing opportunities beyond group meetings and events. Our members are dedicated to ensuring that children and young people have a greater chance of survival and a belter lrfe after Ire8tmenl.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 We support children and young people with cancer and their families in a variety of different ways.. Written by experts. our comprehensive quality-assured range of information booklets, leaflets and online content helps patients and their families understand their diagnosis, treatment and what to expect now and in the future. Our publications are available free of charge to those who need them. Our free quarterly magazine, Contact, offers help, support and information for families of children, teenagers and young adults with cancer. Our online community provides a 'safe space, for parents of children with cancer to come together and share experiences, ask for advice, and, uniquely, ask expert questions of our professional membership. Our website is a comprehensive resource of childhood cancer information, providing a wide range of up- to-date expert information, personal stories and more. The outstanding progress made in cancer treatment is the result of extensive research studies and clinical trials over the last 50 years which now underpin today's standard treatments. During this time. CCLG has played a key role in the success seen in the wodd of children's cancer so that now over 800/0 of children are cured. Bul there are still some childhood cancers with a poor outlook, and some treatments can have long- lasting and devastating side effects. Further research is vital to improve survival rates and lo fi'nd kinder treatments. We fund and support a variety of research into childhood cancers including.. We offer funds and grants lo launch new research projeds and develop new clinical trials. We work in partnership with other charities and organisations to support research. We use our research funding infrastructure, as well as the scientific and medical expertise of our membership, lo support smaller charities lo meet their research aims. For example, by managing a research funding programme or helping them lo identify research to support. We can 'ringfence' funds so that our supporters can raise funds towards a cancer-specific research project. Our Special Interest Groups provide a forum for discussion and planning of research and bring together potential collaborators. We organise and support scientific meetings where research findings are shared and discussed, and we support our membership lo be involved in planning research and attending important meetings through bursaries and sponsorship. During the year, following the closure of the National Cancer Research Inslilule INCRII we took over hosting the Children's Research Group and Teenage and Young Adult & Germ Cell Tumour Research Group, along with their subgroups, which sel UK research strategy. develop new studies and drive forward the research agenda. sin￿ 2017, CCLG has been a member of the Association of Medical Research Charities, demonstrating our commitment to funding high-qualily, world class research and confirming the high standard of the processes we use to select and fund research. We measure our success in achieving OLJr objectives in a number of ways.. The number of patient information products distributed, and the number of visits to the 'about childhood cancerf section of our website, are some measures used to ascertain our success in supporting patients and their families. We also gather feedback on OLJr information products. The number of members and retention of members are some basic measures used to ascertain how w8 are supporting the community of professionals we serve through our professional association activities. The number of research projects funded and their value, and the outcome of research projects including peer-reviewed papers in scientific journals, and the number of projects that led lo further funding from ourselves or another research funder. We have now begun developing our new strategic plan, sel to launch in 2025. As part of this work, we will consider how we beller measure and report on our impact. ACHIEVEMENTS AND PERFORMANCE Around 1,800 children laged 0-14} and a fLJrther 2,300 teenagers and young adults (aged 15-251 are diagnosed with can¢er ea¢h year in the UK. Alhough overall five-year survival for cancer in children and young people is , for some cancers there have not been such dramatic improvements in survival, and even where treatment is successful, many survivors have to contend with life-long and Iife-limiting side effects. Vve continue to work towards the four main goals set out in OLJr strategic plan, launched in 2018, and the goals of the TYAC strategic plan, launched in 2019, as detailed below. Highlights of our achievements during the year are set out under each of these strategic goals.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Providin leadershi and ex ertise for the treatment and care of children and oun eo le wtth cancer As the UK and Ireland's professional association for those working in the field of paediatric oncology and h8ematology, CCLG is a leading voice for children's cancer, liaising with community groups, the government and the NHS to influence policies. We use our expertise to improve treatment and care and meet the needs of patients and families. Highlights for 2023 include.. We hosted the laryesl ever CCLG Annual Collferen￿ in March, bringing together more than 450 professionals to share best practice, hear about the latest research and developments, and network with colleagues. For the first lime, the Conferen￿ included dedicated teenage and young adult cancer sessions, as well as parallel sessions for our mulliprofessional membership. The Annual Conference also saw the retum of the CCLG Member Awards for the second year, recognising dedication and excellence amongst our professional community. We held a number of other in-person educational opportunities for members during the year, including a two4ay specialist course in renal lumours, as well as expanding our online webinar series. We continued to produce and update a number of clinical treatment guidelines, ensuring standardised, high quality and evidence-based Ireatrnent for all children, particulady in diseases where there is currently no open clinical trial. Launch at the end of 2022, CCLG Connect, an online community for the CCLG membership, continued to grow and see increased engagement from the membership. CCLG Connect provides a space for members to connect with each other, participate in group activities, share besl-praclice and research outputs. ask questions and disseminate useful resources. So far, feedback on this new resource has been hugely positive. Our strategic partnership with Young Lives vs Cancer continued, providing benefits to both organisalions. The Chief Nurse role al CCLG is funded by Young Lives vs Cancer, working to provide clinical and health system insight and intelligence to the laller and enhance support for nursing and 811ied health professionals within CCLG. With Young Lives vs Cancer, we called on the government to publish a 10-year cancer plan for children and young people, lo ensure that their unique and critical needs are recognised, understood. and addressed. We want lo work together as a sector with the Department of Health and Social Care lo see a fully resourced, long-term strategy pul in place lo provide the care and support needed to radically improve eXperIen￿S and outcomes for children and young people with cancer. In partnership with Young Lives vs Cancer, the Ellen MacArthur Cancer Trust, and Teenage Cancer Trust, we commissioned a gmund-breaking piece of research that will build a new evidence base looking at the psychosocial needs of young can￿r patients and how the current system supports them. The research will also identify gaps and what needs lo happen in order to build a better future for children and young people diagnosed with cancer. Dartington Service Design Lab, a charity which improves children's outcomes through research, systems thinking and co4esign approaches, was commissioned as the research partner. They undertook experience-led research, co-designed by young people, parents of children with cancer, and key stakeholders. The aim of the research is to improve policies and practice around cancer support and will be published in 2024. We18unched the first in a series of e-learning units to support the development of multiprofessionals in the early years of a career in children or teenage and young adult cancer services. The full sel of nine units will form a foundation course called 'An introduction lo cancer in a child, teenager and young adult, and the remaining units will all be available by the end of 2024. The aim is to improve options and access to foundation level leaming in a timely way, in a formal where learners can choose their own schedule of learning. rovin dia nosis limes b increasin awareness The significance of a delayed diagnosis presents a challenge for primary health care professionals, who are required lo triage symptoms that may point to a cancer diagnosis and make appropriate onward referrals. Many symptoms associated with cancer are non-specific and are seen every day in general practice, whilst a cancer diagnosis is seen infrequently. Delays in the diagnostic pathway may well lead lo more advanced disease at presentation, with subsequent greater risk of death, greater morbidity, and inevitably, distrust of the medical system. There is evidence that tumours presenting in childhood in the UK are larger, at a more advanced stage and require more therapy

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 than those presenting in other parts of Europe. We work to improve diagnosis times for children and young people with cancer. In 2023.. We continued working on our Child Cancer Smart project. which will result in a number of clinical referral guidelines, and public and professional awareness tools, on the signs and symptoms of childhood cancer. Work to date has comprised a significant amount of research to understand the signs and symptoms of childhood cancer, providing an evidence-based approach, for the first lime, lo developing tools lo support medical professionals in making a diagnosis, as well as a series of public campaigns to raise awareness of the signs and symptoms of childhood cancer. We expect lo launch the first tools and campaigns during 2024. The Child Cancer Diagnosis Study, a research project funded by the National Institute for Health Research INIHR) and CCLG, and jointly run by CCLG and The University of Nollingham, closed and the analysis of the data began. This innovative, nationwide research will give us. for the first lime, an accurate picture of the routes lo diagnosis and where we can develop inlervenlions to drive improvements. We published research that shows only 320/0 of adult survey respondents fell confident in recognising cancer signs and symptoms in children, teenagers and young adults. The survey results demonslraled th8t most of the respondents underestimated the risk of cancer in children, selected symptoms associated with adult, rather than childhood cancers, and didn't recognise that disturbed growih or pubertal development were indicators of childhood ill health. Using these results, we can put inlervenlions in place to improve awareness and knowledge amongst the general public, including targeted information for rtain groups, including healthcare professionals lo accelerate diagnosis. This data will be crucial lo informing the Child Cancer Smart awareness campaign, providing information about gaps in public awareness and knowledge which we can address through messaging in the campaign. Stren Ihenin our ex ert information ortlolio to su ort more families of a child with cancer Looking after a child with canTrr Can be a scary and lonely experience for families. Our goal is to deliver the right information at the right time and make a positive difference to their daily lives. We continue lo be the leading provider of expert-writlen, award-winning and quality-assured information about all aspects of childhood cancer, from diagnosis lo life when treatment has finished. In 2023.. We conlinued lo provide free information booklets and leaflets lo hospitals and directly lo families during the year. A number of new publications were produced, and further existing publications were reviewed and revised. We produced four issues of our popular magazine, Contsct. Feedback on the new fomal and design, launched in 2021, continues lo be overwhelmingly positive, and Contact continues lo support families across the UK and around the world. We continued our series of online 'research talks, aimed al parents of children with cancer land the general publicl, which aim to explore the world of childhood can￿r research in an accessible way, with each episode in the series featuring a talk from an expert speaker, as well as the opportunity for allendees lo ask questions. Recordings of the webinars are made available on our YouTube channel for those unable to attend the live events. Our closed Facebook group for parents and carers of children with cancer, which allows members lo seek advice and support from those with similar experiences, and, uniquely, 'ask the experts, through posting questions answered by our clinical membership community, continued to grow, reaching over 1,500 members. We successfully passed our annual reassessment for the Patient Information Forum IPIFI PIFTick accreditation for our health information. This quality standard is awarded following rigorous assessment of our informalion production processes, and demonstrates our commitment lo reliable, expert, high- quality health information. ortin and fundin world-class research Our aim is to both support and fund world-class research, deepen understanding and foster collaborations across the childhood cancer community. One of our most important areas of work is to offer opportunities for our members to develop scientific networks and belong to a wider research community dedicated to childhood cancer.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Our Research Strategy outlines our exciting plans lo fund and support innovative world-c18ss research into childhood cancer and recognises the Importan￿ of collaboration. both nationally and internationally, to achieve improvements. We fund research direcdy. and work with partner charities to support them to fund the best possible research, using our well-established research funding expertise, experience and infrastructure. In total, between our own research funding and that of the partners we work with, 30 new research projects tolalling around £5.8 million were funded in 2023. Grants awarded cover a wide range of childhood cancer types, projects focusing on different parts of the cancer experience, and covering a range of different types of research. Our partnership with The Little Princess Trust continues to go from strength lo strength. We support The Little Princess Trust lo fund the best quality research, with a focus on finding better, kinder Irealments. We provide specialist advice and expertise. as well as run and manage their research-funding programme on their behalf. This partnership helps to minimise duplication, and share expertise meaning that ullimalely more money is spent directly on research. During the year, the Little Princess Trust awarded CCLG around £4.4 million lo fund innovative new research proposals. In September, our partnership with The Little Princess Trust was recognised with a 'highly commended award, in the Charity Partnership of the Year category al the Third Sector Awards. During the year, we also made research grants on behalf of, and funded by, Candlelighters and The Harley Staples Cancer Trust. During the year, the National Cancer Research Institute INCRII, a UK-wide partnership between research funders working together lo maximise the value and benefits of cancer research for patients and the public, sadly announced its closure. As a, NCRI partner, CCLG stepped up lo offer support to the children and young people elements of the NCRI'S work, allowing this vital work lo continue while a longer-tem solution is sought. CCLG continues lo host the previous NCRI 'Children's' and 'Teenage and Young Adult and Gemi Cell Tumour, research groups, which set the research agenda in these areas and contribute to the development of research studies for our patients. We continued lo publish our research blog, aiming lo make research understandable and a¢￿SSIble to all those in the childhood cancer community and beyond, including parents, professionals and the general public. The blog shares research concepts and specific projects in an accessible way, raising awareness of both the research we undertake and of cancer research more generally. In September, we hosted our first Research Discovery Day, to offer valuable insight into the research we fund lo families and supporters. Among the allendees were parents of children diagnosed with cancer, survivors and CCLG fundraisers, who were able lo hear experts from Birmingham Children's Hospital. the University of Nollingham and the University of Oxford tslk about how they're working lo improve the future for children with cancer. Before that, they heard from Emma Jones, whose daughter Ruby passed away from blood cancer in 2020. Emma spoke about Ruby's wish to donate her life savings lo research lo help other young can￿r patients, and why she carries on her daughter's legacy by raising money for research through Ruby's Live Kindly Live Loudly Fund, a Special Named Fund at CCLG. In December 2022, the final workshop of the Children's Cancer Priority Selling Partnership IPSPI, initiated by CCLG and w-funded with The Little Princess Trust, look place and the Top 10 Priorities in Children's Can￿r ReSea￿h were announced. In June, we launched the final report of the PSP with a special event. The findings were presented al the launch event, which brought together charities, researchers and research funders, as well as those affected by childhood cancer. Members of the project team spoke about the importance of the PSP, while the audience heard from a childhoc>d can￿r survivor and parents of childhood cancer patients about what the report means lo them. We continue lo work with partners to ensure that the priorities identified by the PSP now influenTr research funding going fonmard, to ensure that the needs of young cancer patients are reflected in research. Teena ers and Youn Adults with Can￿r r(AC Teenagers and Young Adults with Cancer ITYACI is the professional association for those working in teenage and young adult ITYAI oncology. TYAC merged with CCLG in 2018, and in 2019 we launched a new strategy for the work of TYAC, selling out how we would continue lo drive improvements in TYA cancer care, and support the development of professionals working in the field.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Fundraisin All of our work is dependent on the generosity of our supporters. A programme of fundraising underpins our ability to fund research, support patients and families, and improve treatment and care for children and young people with cancer. Our Special Named Fund programme continued lo grow. After their cancer experiences, families sometimes consider setting up their own charity. For many, our Special Named Funds may be a great alternative. We support families lo achieve their fundraising objectives, while taking away the administrative burden of setting up and running a charity. Al the end of the year, there were approximately 98 Special Named Funds at CCLG 12022.. 851, each raising funds lo support research into a specific type of childhood cancer. During the year, we began wort(ing on a new fundraising strategy, to be launched in 2024, which aims to ensure we are able lo sustain our income growth and continue lo deliver on our charitable objectives.. funding research, supporting families and ensuring that all young patients receive the best possible treatment and care. We are hugely grateful lo all those who chose lo support CCLG, by making a donation, taking part in an event, or organising their own fundraiser during the year. Fundraisin We are reliant on donations lo fund our vital work. Without the generosity of the public, we would not be able to continue providing support to children and young people diagnosed with cancer, and their families, nor fund research into childhood cancer. We believe that it is essential that we are clear and open about how we raise our funds and about the range of ways people can get involved and support our work. People raise money for us in many different ways, including through taking part in sporting events. organising events in their local Community, or fundraising at their place of work. We also provide opportunities for people to fundraise through providing access lo places in key events, such as the London Marathon, and through providing fundraising materials. Our supporters can sign up lo make regular donations, or play our lollery which we launched in 2018. We work with a number of corporate partners, and have received support from charitable trusts and foundations, and through grants from other charities. We do not carry out door-to-door fundraising, nor do we use street fundraising to sign up supporters to regular donations. Currently, none of our fundraising activities are condurted on our behalf by professional fundraising agencies. CCLG is registered with the Fundraising Regulator. We are committed to adhering to the Code of Fundraising Practice. During the year, we received no complaints about our fundraising activities. Regular updates are provided to our board of trustees lo ensure that they have a good oversight of our aclivilies. FINANCIAL REVIEW Transactions for the year ended 31 December 2023 fall into roughly the same categories as in previous years. Income generally consists of donations and fundraising income, subscriptions {comprising individual membership subscriptions and hospital subscriptions for health inform8tionl, registration fees for meetings and events, funding from partner charities such as The Little Princess Trust lo support research projects, and legacy income. We are grateful lo Young Lives vs Cancer, Teenage Cancer Trust and The Little Princess Trust for their support of specific areas of our work. We also benefitted from a grant from The Medical Research Council UK Government COVID Medical Research Charity Support Fund, a scheme designed lo support fundraising medical research charities who fund early-career researchers in response lo the COVID-19 pandemic.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 The major items of expenditure for CCLG remain staff salaries, professional meeting and event costs, the costs associated with the production of health information, and the awarding of research grants. Staffing costs represent a significant financial commitment, but our small, expert staff team is also responsible for the achievement of the majority of our charitsble objectives. Staffing levels are kept under review, with the small, efficient team carrying out and coordinating the considerable activities of the charity. Our overall income increased by £167,538, compared with the year ending December 2022. There was a small decrease in donations for the year, and an increase in income from meeting registration fees as more events were held in-person following the reduction in number over the past few years caused by the COVID- 19 pandemic. CCLG has a number of restricted funds. Internal records are kept according to requirements for restriction, i.e. disease-specific donations for research into a specific type of can￿r, or donations for a specific piece of work. The reslricled funds are ring-fenced lo support specific projects or areas of adivily and cannot be used lo support the general running costs of the organisation. Expenditure decreased in 2023 by £122,277 compared to 2022. While our expenditure on research decreased, expenditure increased slightly on our health information and professional body activities. We ended the year with an overall surplus of £827,665. There was a deficit in unrestricted incomelexpendilure of £101,002, which was planned and represents the Trustees commitment to invest reserves held above the level of our reserves policy into our charitable aclivilies. There was a surplus in restricted incomelexpenditure of £928,657. Much of our reslricled funding is for research, and often funds build over several years before being expended in significant amounts to fund research projects. We plan to invest a significant amount of restricted funds in the next 12 months. Reserves Polic The trustees continue to consider the appropriate balance of financial stability and investment in charitsble aclivily. The COVID-19 pandemic has highlighted the importance of an appropriate reserves policy. 11 is important we continue lo hold a level of reserves which can sustain our activity until we have a fuller picture of what posl-pandemic fundraising might look like in the medium-term. We have plans in place to ensure CCLG is 'fil for the future, and our reserves policy will ensure we are able to meet those plans. Al the end of the year, we have reviewed our reserves policy for CCLG and aim lo hold a target level of free reserves lunreslricted funds less tangible fixed asselsl of £400,000, which the trustees consider lo be approximately six months of core expenditure, including staff salaries, accommodation costs and general running costs. Total reserves at 31 December 2023 were £3,288,552 of which £2,898,594 are restricted and £389,958 are unreslricled. As al 31 De￿mber 2023 the charity's free reserves tolalled £358,954 which is just below the reserves policy. Given the current economic uncertainty, the Iruslees consider it prudent to balance the investment of reserves into our charitable activity whilst ensuring sufficient funds are available to ensure the charity is a 'going con¢em' and able to meet ils ¢ommilments. The Trustees continue to keep the reserves policy under review lo ensure that CCLG is 'fit for the future,. Our restricted reserves appear high, at £2,898,594 al the end of 2023. Much of our restricted fundraising income is raised by families. ring-fenced for research into specific types of childhood cancer. Research requires significant investment, and thus many of our funds grow over the course of several years before a large sum of money is awarded in the form of a research grant. Our restricted reserves comprise a large number of specific restricted hjnds which are ring-fenced lo a specific purpose, and therefore cannot be used for general aclivilies. Levels of funds are reviewed on a regular basis and spent on charitsble activities as soon as sufficient funds are available. We are planning lo invest a significant amount of reslricled reserves into research during 2024.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Investment olic The Trustees previously reviewed our plans for investments lo consider the most appropriate way of managing these, balancing cashflow, risk and reward. Given the ongoing uncertainly ofthe financial impact ofthe COVID- 19 pandemic, and the cost-of-living crisis and high inflation, no further action has been taken on investments. The high interest rates during the year have resulted in increased investment returns in the form of interest on money held in our bank accounts. Management accounts are produced for the trustees, and a cashflow forecast considerably facilitates management and prediction of charity income. Risk Mana ement CCLG is also aware of the requirement to carry out a risk review of ils aclivilies. The trustees reviewed the risks the charity faces during the year. A Risk Register is in operation, documenting the systems in place to mitigate those risks, and is kept under review by the trustees. FUTURE ACTIVITIES All future activities planned are designed lo ensLJre that CCLG continues to fulfil its objectives for children and young people with cancer. and their families, as the ultimate beneficiaries. As the membership of CCLG continues lo grow. so does the activity our members are involved in. Our specialist network groups continue to be increasingly active, supporting our activities and providing specialist advice to commissioners of healthcare services and others. The Executive continues to consider ways that CCLG can advance education and professional development, and share and guide best practice. Key planned activity for the next 12 months includes.. Researching, designing, building and launching a new website. Merging the CCLG and TYAC memberships into a single membership body, for professionals wort(ing in the field of childhood andlor teenage and yOLJng adult cancers. This will increase the range of support available for members and enabling the resources currently used to maintain two membership functions to be reinvested into other activities. Towards the end of the year, we will launch a refreshed brand for the organisation, that better articulates the wide range of activities we are involved in, reflects that the organisation works across the 0-25 age range, and engages a larger number of supporters. This will include the launch of a new website that uses more modern technology and better meets the needs of our various audiences. We will develop and launch a new research strategy, which reflects our position as a leader in setting the research agenda, and aligns our funding work with the Top 10 Research Priorities for Children's Cancer identified through the Children's Cancer Priority Setting Partnership. A key aim of the strategy will be increasing collaborative and partnership working across the sector to ensure more world-class research is funded, more quickly. Reviewing our health information content and increasing the range of content available in alternative formals, in particular videos, to beller meet the needs of our intended users We will launch the first guidelines, clinical decision tools and public awareness campaigns from our Child Can￿r Smart work, raising awareness of the signs and symptoms of cancer in children and young people, and equipping healthcare professionals to make qLJicker diagnoses. STRUCTURE GOVERNANCE AND MANAGEMENT The Children's Cancer and Leukaemia Group ICCLGI was established in 1977 and became a registered charity Inumber 2866691 in 1983. In 2019, a new CIO Iregislration number 11826371 was fomed. with the aclivilies, assets and liabilities of the previous charity transferred to the CIO. The charity s governing instrument is the Constitution and the CIO was first registered in February 2019. In 2020, the CIO became registered with the Scottish Charity Regulator Iregistration number SC0499481.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 The board of trustees is independent of the CCLG membership. The board of trustees is responsible for managing the charity finances in support of the objectives defined by the CCLG Executive. There are a minimum of two and a maximum of eight Iruslees. One of the Iruslees will be an elected member of the CCLG Executive. providing a link between these two groups. If a vacancy arises, the Iruslees may appoint any eligible person as a trustee. In selecting individuals for appointment as trustees, the trustees will consider the skills, knowledge and experience needed for the effective running of the charity. Upon appointment, Iruslees are provided with an induction to the charity. This consists of a briefing paper, as well as meetings with the Chair, CEO, and others as deemed appropriate. Regard is given lo the training and development needs of any trustees that may arise. The board of Iruslees meets quarterly and is supported by slaff. Four meetings were held in 2023. The Iruslees come from a range of professional backgrounds, and bring new skills and highly relevant experience. Trustees serving during the year were.. David Oxn2m (Chair of Board of Trusleesl Gayle Routledge Rachel Wilcox David Hobin Sarah Curtis The Chief Executive is responsible for the day-to-day operation of the charity on behalf of the trustees. The remuneration of key management is reviewed annually and is set against established pay scales, benchmarked in comparison with similar sized entities including both charities and medical professional associations. The trustees give their lime freely and no remuneration was paid in the year. Details of trustee expenses are disclosed in note 12 to the accounts. Key Management Personnel during the year were.. Ashley Ball-Gamble Ichief Execulivel Vicki Brunt (Head of Fundraising) Claire Shinfield (Head of Engagement) Jeanette Hawkins (Chief Nurse) STATEMENT OF TRUSTEES. RESPONSIBILITIES The trustees are responsible for preparing the Trustees, Report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practi￿1. The law applicable to charities in England & Wales and Scotland requires the Iruslees lo prepare financial ststements for each financial year which give a true and fair view of the slate of affairs of the charity and of the incoming resources and application of resour￿$ of the charity for that period. In preparing these financial stalemenls, the Iruslees are required lo: select suitable accounting policies and then apply them consislenlly., observe the methods and principles in the Charities SORP 2019 IFRS 1021., make judgements and estimates that are reasonable and prudent., stale whether applicable accounting standards have been followed, subject to any m8terial departures disclosed and explained in the financial slatemenls., prepare the financial statements on the going concem basis unless it is inappropriate lo presume that the charity will continue in operation. The Iruslees are responsible for keeping proper accounting records that disclose with reasonable accuracy al any lime the financial position of the charity and enable them to ensure that the financial statements comply with the Charities Act 2011, the Charities and Trustee Investment (Scollandl Act 2005, the Charities (Accounts and Reports) Regulations 2008, the Charities Accounts (Scollandl Regulations 2006 las amended) and the provisions of the charity's constitution. They are also responsible for safeguarding the assets of the charity and hence for tsking reasonable steps for the prevention and detection of fraud and other irregularities.

Docusign Envelope ID." A1B3A320-1BCW44D9-AEBt>AE2D6F204600 THE CHILDREN'S CANCER AND LEUKAEMIA GROUP TRUSTEES. REPORT (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 The trustees are responsible for the maintenance and integrity of the charity and financial information included on the charity s website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions. Do¢uSWid by.. 29DQBSFD6U71VX. David Oxnam Chair of the board of trustees 16-08-2024 Date.. 10-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP INDEPENDENT AUDITOR'S REPORT TO THE TRUSTEES OF THE CHILDREN'S CANCERAND LEUKAEMIA GROUP Opinion We have audited the financial slalements of The Children's Cancer and Leukaemia Group Ilhe 'charily'l for the year ended 31 December 2023 which cornprise the slalement of financial aclivilies, the balance sheet, the slalement of cash flows and notes lo the financial slalements, including significant accounting policies. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom A¢¢ounling Standards, including Financial Reporting Standard 102 The Fiftancial Reporting Standard applicable in the UK and Republic ol I￿land (United Kingdom Generally Accepted Accounting Practice). In our opinion the financial ststemonls.. give a true and fair view of the state of the charity's affairs as at 31 December 2023 and of its incoming resources and application of resources, for the year then ended., h8ve been propedy prepared in 8¢cord8nce with United Kingdom Generally Accepted Accounting Practi￿., and have been prepared in accordance with the requirements of the Charities Act 2011, the Charities and Trustee Investment (Scotlandl Act 2005 and regulation 8 of the Charities Accounts (Scotlandl Regulations 2006. Basis for opinion We conducted our audit in accordance with International Standards on Auditing IUKI IISAS IUKII and applicable law. Our responsibilities under those standards are further described in the Audilorfs responsibilits.es for the audit of the fin8n¢ial $18temenls section of our ￿port. We are independent of the charity in 8ccord8n¢e with the ethical requirements that a￿ relevant to our audit of the financial statements in the UK, in¢luding the FRC'S Ethical Standard, and we havè fulfilled our other ethical rèsponsibilitiès in accordance with these r8quirements. WÉ bèli8Vè that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion. Con¢luslons relatlng to golng ¢on¢¢rn In auditing the financial statements, we have concluded that the trustees. use of the going concem basis of accounting in the preparation of the financial statements is appropriate. Based on the work we have performed, we have not identified any material uncertainties relating lo events or conditions that, individually or collectively. may cast significant doubl on the charity's ability lo Continue as a going ncern for a period of at least twelve months from when the financial statements ar& authorised for issue. Our responsibilities and the responsibilities of the trustees with respect to going wn¢ern are described in the relevant seclions of this report. Other Infomiatlon The other information comprises the information included in the trustees. report, other than the financial statements and our auditor's report Ihereon. The trustees are responsible for the other information contained within the trustees. report. Our opinion on the financial statements does not cover the other information and, except to the exlenl olheTwise explicitly ststed in our report, we do not express any form of assurance conclusion Ihereon. Our responsibility is lo read the other information and, in doing so, considtrr whtrlher the other information is materially inconsistent with the financial statements or our knowledge obtained in the wurse of the audit or otherwise appears to be materially misstated. If we identify SLJch material inconsistencies or apparent material misstatements, we are required to detemiine whether this gives rise to a material misstatement in the financial statements themselves. If, based on the work we have performed, we conclude that there is a material misslatemenl of this other information, we are required to report that fact. We have nothing to report in this regard.

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP INDEPENDENT AUDITOR'S REPORT {CONTINUED) TO THE TRUSTEES OF THE CHILDREN'S CANCERAND LEUKAEMIA GROUP Matters on which we are required to report by exception We have nothing lo report in respect of the following matters in relation lo which the Charities (Accounts and Reports) Regulations 2008 and the Charities Accounts Iscotlandl Regulation5 2006 require us lo report to you if, in our opinion.. the information given in the financial statements is inconsistent in any material respect with the trustees, report,. or the charity has not kept adequate and proper accounting records., or th8 financial statéments aré not in agrèèment with the accounting rècords and rgturns- or we have not re￿iVed all the information and explanations we require for our audit. Responsibilities of trustsas As explained more fully in the Iruslees. responsibilities statement sel out on page 9, the trustees are responsible for the preparation of the financial ststemenls and for being satisfied that they give a true and fair view, and for such intemal control as the trustees determine is ne￿$s￿ry to enable the p￿paratIOn of financial slalemenls that are free from material misslalemenl, whether due to fraud or orror. In preparing the financial statements, the trustees are responsible for assessing the charity's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the trustees either intend to liquidate the charity or to cease operations, or have no realistic altemalive but lo do so. Auditor's responsibilities for the audit of the financial statements Vve have been appointed as auditor under section 144 of the Charities Act 2011 and section 441111¢) of the Charities and Trustee Investment (Scollandl Act 2005 and report in accordance with regulations made under these acts. Our objectives are to obtsin reasonable assuran￿ about whether the financial slalements as a Who￿ are free frorn alerial misslalement, whether due lo fraud or error, and lo issue an 8uditorfs report that includes our opinion. Reasonable assurance is a high level of assurance bul is not a guaonlee that 8udil conducted in 8¢cord8n with ISAS IUKI will always detect a material misstatement when it exists. Misststemenls Can arise from fraud or érror and aré considerèd material if, individually or in th8 aggregate, they could reasonably bè èxp8Ct8d to influencè the economic decisions of users taken on the basis of these financial statements. Irregularities, in¢lLJding fraud, are inStsn￿$ of non-¢omplIan￿ with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities. including fraLJd. The extent to which our procedures are capable of detecting irregularities, including fraud, is detailed below. Ext&nt to whi¢h th& audit was ¢on$ldored Capable of detecting irregularitl¢$ We identify and assess the risks of material misstatement of the financial statements, whether due to fraud or error, and then design and perform audit procedures responsive lo those risks, including obtaining audit evidence that is sufficient and appropriate lo provide a basis for our opinion. However, responsibility for the prevention and detection of fraud ultimately rests with both those charged with governance and management of the charity. In identifying and assessing risks of material misstatement in respect of irregularities, including fraud and non- compliance with laws and regulations, our procedures included the following". obtsining an understanding of the legal and regulatory framework applicable lo the charity by considering the nature of the industry in which the charity operates and enquiring of management,. and identifying the key laws and regulations considered lo have a direct impa¢t on the financial slatamtrnts including the UK Charities A¢t 2011, Charities and Trustee Investment IS¢otlandl Act 2005, UK Generally A¢¢epted AccoLJnting Practice and UK tax legislation., and assessing how the charity is complying with the applicable legal and regulatory framework by making further enquiries of management and observing the charitys control environment regarding compliance with regulations and fraud prevention., and assessing the susceptibility of thé charity's financial statèmènts to material misstatement, induding how fraud might occur, by considering the effectiveness of the charily's accounting systems and controls and h)w these were monitored by managemenl. Where Ihe risk Df material misslalement was considered to be higher in certain areas, further audit procedures were designed to address this increased risk., and 12

THE CHILDREN'S CANCER AND LEUKAEMIA GROUP INDEPENDENT AUDITOR'S REPORT (CONTINUED) TO THE TRUSTEES OF THE CHILDREN'S CANCERAND LEUKAEMIA GROUP discajssing arnongst the engagement team and fra￿j mvJhl ooxr in the finandal ststemenl8 and any wJt8ntial indicators of fraud. Audlt mpon•o to rl•k• of Irr•gularltl•¥ Identlfi Oui proceduTes lo respond to risks idtrnts.fied induded the fdhJwlThJ." rfomiing audit work over revenug rgc4)gnition inthding anatybcal wocgdures and subslanlive le8t8 of detad of a Samp￿ of rO￿lly¥ Iranso¢tk)ns", and rovi￿1n9 finanual statem￿1 dtsch)$ure$ * lestvw lo supwting d0￿Mental￿ lo asse88 tsjmpliance wrfh applicatAe laws and regulations.. and enquiry of ¢harity stsff r•sponsth for cymplian¢• to idontify any in$tan¢•$ of non-¢ompliance wth laws and regulatlons.. and &nquiry of mana9ement, IW charyod with goI￿an￿ and othfjr rel8¥onl parties around actual and lenlial lrftyalion dalms; and revigwing minutes of me&lings of th088 tharged with govemanc8.' arml performing audit work over the risk of manag8ment ove￿Ide of controls. indudlng testing of Soumal entrfes and oth8r adjuslmenls for appropriateness, •valuating the business rat￿ale of signrfunt transa￿lon5 outside the nomlal course of business and revbthying ac¢ountmg estimates for bia$', and eommLtnicating ￿en￿rIed I￿S and r￿ulationS and potential fraud risks to all 8ngag8mgnl l•¥m momb8r6 and 8ssessing wh&lher there are any indicalions of fr8ud Of nOr￿(%)mpliancfj wlth 18ws 8nd regulations IhroughoLrt thè audil. Because of the inherent l1rn1tat￿ns ol an audit. there is a risk that we will not detect all irregularitlos, indudkng tho86 18ading to a material misslalement in the finanaal statements or non-compkn'ance with r8gulatKJn. This risk inffta5es the more that complian¢8 with a law or régulation 1$ r•moved from th8 evènts and transa¢lions reflected In Ihe financial slal¥menl$, as ￿ w￿1 be less likety lo b￿rne aware ol instan￿$ of t)owompliance. The risk is also preatèr regarding irregul8ri1s occurmg due lo fraud r¥th¢f than error, a$ fraud involves intenlional concA•alm8nt, forgery, ¢dlu8th). Omiss￿ or misrtprèsentation. A furth•r des¢riplion of our r8$ponsibilrtie$ 1$ availab￿ on Financial Reporling Coun¢M'$ websttt 8t.. https'.11 ￿￿.fr¢.0rq.Ukla￿￿rt￿sl8Spons￿l1ths. This des¢riplw fwms part of our oudrtorf$ rgport. U•• of our r•port This report is made sdety to the tharity's Irusttts, as a botty, in accordance wlih Part 4 of the Ch8rtties IA¢counl$ and Reports) Regulations 2008, and Regu￿￿on 10 01 th8 Charit￿S A¢counts IS¢oUandl R•gulations 2(£fj. Our audit work h#5 been undertaken so that we might $tste lo thg charrtl$ Iru$lee$ those matters we are required lo state lo them in an audilots. report 8nd for no other pu￿4>60. To th& lull&sl extent pemitted by IWH, wa do nol accept or assume responsibilty to anyone other than charity aThl Ihe than￿8 trusl•es as a body. for our audlt wort. for this report. or for the opini N•wby Ca•tl•m•n LLP Chartered Accountants Slatulory Auditor Wesl Walk BuihJir4J 110 Regent Road Leicester LE1 7LT 27 August 2024 N￿bY Caslleman LLP is eligit4e to ad as an auditor in lern5 of sedion 1212 of the CompaniesA¢t 20￿. 13-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP STATEMENT OF FINANCIAL ACTIVITIES FOR THE YEAR ENDED 31 DECEMBER 2023 Unrestricted Restricted funds funds 2023 2023 Total Total 2023 2022 Notes Income from.. Donations and legacies Charitable activities Inveslrnenls 752,941 352,395 56,177 2,047,741 5,270,059 2,800,682 5,622,454 56,177 1,897,074 6,408,766 5,935 Total 1,161,513 7,317,800 8,479,313 8,311,775 Expenditure on.. Raising funds Charitable activities 311,783 950,732 36,224 6.352,919 348,007 7,303,651 377,048 7,396,887 Totsl 1,262,515 6,389,143 7,651,658 7,773,935 Net lexpenditurellincome for the yearl Net movement In funds 1101,0021 928,657 827,655 537,840 Re¢onciliation of funds Total funds brought forn￿ard 490,960 1,969,937 2,460,897 1,923,057 Totsl fund$ ¢arrled forward 389,958 2,898,594 3,288,552 2,460,897 14

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP BALANCE SHEET ASAT 31 DECEMBER 2023 2023 2022 Notes Fixed assets Tangible 8ss&ts 14 31,004 42,486 Current assets Stocks Debtors Cash al bank and in hand 1S 16 55,061 5,373,880 5,105,709 53,029 4,922,609 4,025,410 10,534,650 9,001,048 Llabllltles Creditors.. amounts falling due within one year 17 14,893,8191 13,967,898) Net current assèts 5,640,831 5,033,150 Totsl assets less Current 118bllltles 5,671,835 5,075,636 Creditors- amount5 falling due after more than one year 18 12,383,283) 12,614,739) Total nat assets 3,288,552 2,460,897 The funds of the charity Reslricled funds Unrestricted funds 20 21 2,898,594 389,958 1,969,937 490,960 Total ¢harity fund$ 3,288,552 2,460,897 16-08-2024 The finanaal statements were approved and authorised for issue by the board of trustees on are signed on its behalf by.. and Dow$￿￿•d by.. '29D0￿F￿LlrfjIJ￿" David Oxnam (Chair of Board of Trusleesl Trustee The notes on pages 17 - 31 fomi part of these financial statements. 15-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP STATEMENT OF CASH FLOWS FOR THE YEAR ENDED 31 DECEMBER 2023 2023 2022 Note Cash flows from operating activities Cash generated fromll8bsorbed byl operations 26 1,026,714 113,5271 Investing activities Purchase of tangible fixed assets Investment income re￿iVed 12,5921 56,177 114,1131 5,935 Net cash generated fromllused in) investing activities 53.58S 18,1781 Net cash used in financing activities N¢t In¢r¢a$&lld¢¢rease} In ¢a$h and ¢ash equlvalonts 1,080,299 121,7051 Cash and cash equivalents at beginning of year 4,025,410 4,047,115 Cash and cash equivalents at end of year 5,105,709 4,025,410 16

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2023 Accounting policies Charity infomiation The Children's Cancer and Leukaemia Group is govemed by ils Constitution. 1.1 Basis of preparation The charity is a public benefit entity as defined by FRS102. These financial stalernenls have been prepared in accordance with.. The Financi81 Reporting Stsndard applicable in the United Kingdom and Republic of Ireland I'FRS 102,1, A¢¢ounling and Reporting by Charities.. the Statement of Recommended Pra¢lice for charities applying FRS 102 120191, the Charities Act 2011, the Charities and Trustee Investment (Scotlandl Act 2005, and UK Generally Accepted Accounting Practice. Th& financial ststemenls are prepared in steding, whi¢h is the fun￿lonal ¢urren¢y of the ¢harily. Montrtsry amounts in these financial statements are rounded to the nearest £. Th& financial stslements have ￿en prepartrd under the historical cost convention. The principal accounting policies adopted are sèt out bglow. These policies havg been Consistently appligd. 1.2 Going Goncern At the time of approving the financial statements, the trustees have a reasonable expectation that the charity has adequate resources to continue in operational existence for the foreseeable future. Thus the trustees continue to adopt the going concern basis of accounting in preparing the financial statements. 1.3 Charitable funds Unrestricted fLJnds are available for use at the discretion of the trustees in furtherance of their charitable objectives unless the funds have been designated for other purposes. Restricted funds are funds which are to be used in accordan￿ with specific reslriclions imposed by donors or which have been raised by the charity for particular purposes. The cost of raising and administering such funds are charged against the specific fund. The aim and use of each reslricled fund is sel out in the notes lo the fin8n¢i81 ststemenls. 1.4 Income recognition Income is recognised when the charity is legally entitled to il after any performance conditions have been rnet, the amounts can be measured reliably, and it is probable that incorne will be re￿ived. Cash donations are re¢ognised on re¢gipt. Other donations are re¢ognis¢d once the charity has been notified of the donation, unless performance conditions require deferral of the amount. Income tax recoverable in relation to donations received under GiftAid or deeds of covenant is recognised at Ihe time of the donation. For legacies, income is recognised and included in the financial statements when all of the followng criteria are mel.. the charity has enlitlernenl lo the funds., any performance conditions 8118ched lo the ilemlsl of income have been mel or are fully within the control of the charity., th8r8 is sufficient certainty that receipt of the income is considarèd probable," and the amount can be measured reliably. Where legacies have been nolified to the charity but the criteria for income recognilion have not been met, then the legacy is treated as a contingent asset and disclosed if material. Government grants are recognised al fair value when the charity has entillemenl after any performance onditions have been mel, rt is probable that the Income will be received and the amount can be measured with reliability. If enlilltrment is not met, then the amounts are deferred. 17-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Accounting policies (Continued} Income from charitable activities includes income received from grants, registration fees for meetings, member subscriptions and publication payments. Such income is recognised al fair value when the charity has entitlement after any performance conditions have been mel, il is probable Ih8t the income will be ceived and the amount Can be measured with ￿lIabIlIty. If enlidement is not mel, then the amounts are deferred. Inveslment income is earned through holding assets for investment purposes. It comprises bank interest and is recognised on an accruals basis. 1.5 Expenditure recognition All expenditure, including the awarding of grants, is accounted for on an accruals basis and has been classified under headings that aggregate all costs relating to the category. Expenditure is recognised when there is a legal or constructive obligation to make payments to third parties, it is probable that settlement will be required and the amount of the obligation can be measured reliably. It is recognised under the following headings.. Costs of raising funds includes costs incurred in seeking donations, grants and legacies. website costs and advertising. Expenditure on charitable activities includes iesearch, edu¢81ional activities and professional association activities lo further the dglivery of the obje¢liv&s of the charity. 1.6 Support costs Support costs are those that assist the work of the charity bul do not directly represent charitable activities and costs of raising funds and include office costs, governance costs 8nd adminislr8tive payroll costs. They are incurred directly in support of expenditure in line with the objectives of the charity. Support costs are allocated lo costs of raising funds and expenditure on charitable activities on a basis consislenl with use of th8 resourcès. The analysis of these costs is included in note 10. 1.7 Tangible fixed assets Tangible fixed assets are measured at cost. net of depre¢iation and any impaimient losses. Depreciation is recognised so as to write off the cost of assets less their residual values over their useful lives on the following bases.. Computer equipment, furniture and fixtures 5-10 years 1.8 Stocks Stocks include merchandise stock and educational literature. Stocks that are held for resale are stated at the lower of cost and estimated selling price. Stocks held for distribution as part of the charity's act'vilies are valued al their service potential, which the charity considers lo be the cost of the materials. 1.9 Cash and cash equivalents Cash and cash equiv8lenls include cash in hand, deposits held at call with banks, other short-temi liquid investments with original maturities of three months or less. 1.10 Financial instruments Financial instruments are recognised in the charity's balan￿ sheet when the charity becomes party to the contractual provisions of the inslrument. Debtors and creditors with no slated interest rate and receivable or payable within one year are measured at transaction price. Any losses arising from impairment are recognised in the Statement of Financial Activities. 18-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Accounting policies (Continued} 1.11 Employee benefits When employees have ￿ndered service to the Charity, short-term employee benefits to which the employees arè entitled are recognised at thè undiscountèd amount expected to be paid in exchangè for that servica. The cost of any unused holiday entitlement is recognised in the period in which the employee's services are received. Termination benefits are recognised immediately as an expense when the charity is demonstrably committed lo terminate the employment of an employee or lo provide lerminalion benefits. 1.12 Retirement benefits Payments lo defined contribution retirement benefit schemes a￿ charged as an expense as they fall due. Critical accounting estimate5 and judgements In the application of the charity's accounting policies, the trustees are required lo rNake judgements, estimates and assumptions about the carrying amount of assets and liabilities that are not readily apparent from other SoUr￿s. The estimates and associated assumptions are based on historical experien￿ and other factors that are considered to be relevant. A¢tual results may differ from these eslimales. The estimates and underfying assumptions are reviewed on an ongoing basis. Revisions to a¢¢ounting estimates are recognised in the period in which the estimate is revised where the revision affects ￿lY that period, or in the period of the revision and future periods where the revision affects both current and future periods. Key sources of estimation uncertainty The eslimales and assumptions which have a significant risk of causing a material adjustment lo the carrying amount of assets and liabilities are as follows.. Allocation of support costs Th& allo¢alion ol support costs is sensitivé to ¢hangÈs in th8 lèvel of work undèrtakén on each aetivity by the ¢harily. The allocation is reassessed annually and amended when ne¢essary lo reflect Current eslimales. Income from donations and legacies Unrestricted Restricted funds funds 2023 2023 Total Unrestricted funds 2022 Restricted funds 2022 Total 2023 2022 Donations Legacies 622,960 129,981 703,031 1,000 1,325,991 130,981 574,290 222,369 825,676 1,399,966 33,417 255,786 752,941 704,031 1,456,972 796,659 859,093 1,655,752 19-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Income from charitable activities Unrestricted Restricted funds funds 2023 2023 Total Unreslricled Restricted funds funds 2022 2022 Total 2023 2022 Règistration fèes for meetings and other project expenditLJre Member subscriptions and publication payments Grant in¢ome for research and operations CLIC Sargent chief nurse funding 126,757 28,299 1 $5,056 90,942 18,244 109,186 153,279 153,279 162,715 162,715 72,359 6,506,385 6,578,744 93,509 6,205,417 6,298,926 79,085 79,085 79,261 79,261 352,395 6,613,769 6,966,164 347,166 6,302,922 6,650,088 Income from Invèstmènts Unrestricted funds 2023 Total Unrestri¢ted funds 2022 Total 2023 2022 Interest 56,177 56,177 5,935 5,935 Expendlturè on ralslng funds Unrestrlcted Restrl¢ted funds funds 2023 2023 Total Unrestricted funds 2022 Restricted funds 2022 Total 2023 2022 Fundraising platform fees Website Fundraising, marketing and PLJblicity costs Support costs Inote 101 30,237 3.567 30,237 13,041 24,576 2,077 24,576 2,077 9,474 110,813 167,166 26,750 137,563 167,166 188,604 161,791 188,604 161,791 311,783 36,224 348,007 377,048 377,048 20-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Expenditure on charitable activities Activities undertaken directly Note 8 Grant fundlng Support Costs Total 2023 Total 2022 Note 9 Note 10 Support for research Informalion for patients and families Improving treatment and care 244,693 5,963,846 72,837 318,319 173,166 6,381,705 6,613,379 258,514 331,351 299,845 272,276 590,595 483,663 635,849 5,963,846 703,956 7,303,651 7,396,887 Unrestricted funds Restricted ftjnds 950,732 872,045 6,352,919 6,524,842 7,303,651 7,396,887 Exp¢ndltur• on a¢tlvltles undertaken dlrectly Support for Information Improving research for patients treatment and famlll•s and car• Total 2023 Total 2022 Staff costs Other tumour specific expenditure Contact magazine expenses other publication expenses Website Cost of meetings Travel expenses Membership support Costs Olher expenses 189,557 42.095 189,557 42,095 21,107 32,169 52,163 266,303 13,906 11,767 6,782 97,944 10,530 20,360 28,312 8,311 192,068 11,729 12.453 6,728 21,107 32,169 19,561 13,041 19,561 266,303 13,906 11,767 6,782 244,693 72,837 318,319 635,849 388,435 21

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 Expenditure on grant funding Support for research Total 2023 Total 2022 Grants to institutions.. University of Birmingham Newcastle University UCL Institute of Child Health University of Sheffield University of Nottingham University of Bristol Queen's University Belfast University of Southampton University of Glasgow University of York University of Cambridge Institut6 of Cancer Research University of Leeds University of Manchester University of Oxford University College Cork University of Lei¢ester Bimiingham Children's Hospital King's College London The Open University Brunel University London Leeds Teaching Hospi181s NHS Trust University of Edinburgh University of Sussex University of Liverpool Imperial College London 942,299 437,890 409,691 213,725 287,497 321,339 942.299 437,890 409,691 213,725 287,497 321,339 939.992 1,146,110 991,135 432,059 401,433 13,9251 222,463 124,806 559,734 248,355 494,146 96,468 222,463 124,806 559,734 248,355 494,146 96,468 140,420 317,285 325,179 210,885 357,187 11,0771 33,854 199,399 52,097 199,399 52,097 112,515 53,277 850,659 29,909 352,568 104,631 175,990 249,969 170.788 299,991 352,568 104,631 175,990 249,969 170,788 299,991 5,963,846 5,963,846 6,336,897 The charity awards grants for specific research projects to various institutions, as part of their charitable activities. Negative amounts represent an underspend on grants previously made, retumed lo CCLG. 22-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 10 Expenditure on support costs Basis of allocation 2023 2022 Staff costs Deprecialion & loss on disposal Occupancy expenses Postage Staff training Professional fees 653,872 14,074 143,429 14,253 10,205 35,289 656,900 13,069 120,538 14,789 3,658 24,392 '11-2 871,122 833,346 Analysed between Raising funds Charitablè activitias 167,166 703,956 161,791 671,555 871,122 833,346 .1 Support Costs, excluding goveman¢e costs, have bgen allo¢ated as follows: Cost of raising fvnds Charitable activilies Support for research Information for patients and families Improving Irealmenl and care 20°/.12022- 20 /.) 30°/.12022- 30 /.) 30°/.12022- 30 /.) .2 Professional fees include governance costs of £35,289 12022 - £24,392). Governance costs have been allocated as follows.. Charitable 8ctNvitNes Support for research Information for patients and families Improving treatment and care 17¢/012022 . 17Q/ol 61°/o12022- 61 /ol The amount charged to the SOFA in respect of auditorfs remuneration was.. statutory audit £9,78012022- £9,300) other services £98912022- £1,2531 11 Taxatlon The charity is exempl from tsxation on ils a¢livilies because all its income is applied for charitable purposes. 12 Trustees None of the trustees lor any persons wnnecled with them) received any remuneration or benefits during the year. -23-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 13 Employees The average monthly number of employees during the year was.. 2023 Number 2022 Number Total 22 22 Employment ¢ost$ 2023 2022 Wages and salaries Social security costs Other pension costs 709,013 68,378 66.038 633,405 63,204 58.235 843,429 754,844 The number of employees whose 8nnual remuneration (including pension contribulionsl was more than £60,000 is as follows.. 2023 Number 2022 Number £60,001 - £70,000 £70,001 £80,000 £80,001 - £90,000 £90,001- £100,000 £100,001- £110,000 Remuneration of key management personnel The remuneration of key management personnel, is as follows. 2023 2022 Aggregate Compensation 272.052 253,428 -24-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 14 Tangible fixed assets Computgr equipment, furniture and fixtures Totsl Cost Al 1 January 2023 Additions 87,438 2,592 87,438 2,592 Al 31 December 2023 90,030 90,030 Depreciation and impairment Al 1 January 2023 Depreciation charged in the year 44,952 14,074 44.952 14,074 At 31 December 2023 59,026 59,026 Carrying amount Al 31 December 2023 31,004 31,004 Al 31 De¢&mber 2022 42,486 42,486 15 Stocks 2023 2022 Merchandise stock Educational literature 31,790 23,271 30,263 22,766 55.061 53.029 -25-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 16 Debtors 2023 2022 Amounts falllng due wlthln one year: Trade debtors Grant deblors Rent deposit Prepayments and a￿rUed income Accrued legacy income 19,656 3,512,427 16,200 150,076 138,500 7,833 2,830,745 16,200 155,731 172,500 3,836,859 3,183,009 2023 2022 Amounts falling due after more than one year.. Grant debtors 1,537,021 1,739,600 Total debtors 5,373,880 4,922,609 17 Crèditors= amounts falling duè within onè yèar 2023 2022 Deferred income Tradè c￿dItorS Grant creditors Accruals 19,559 16,316 4,821,058 36,886 100 17,056 3,911,669 39,073 4,893,819 3,967,898 Deferred incorne includes income received in respect of meetings postponed until the next financial year. 18 Creditors: amounts falling due after more than one year 2023 2022 Grant c￿dItorS 2,383,283 2,614,739 19 Retirement benefit schemes Defined contribution schemes The charity operates a defined contribution pension scheme for all qualifying employees. The amount recognised in unrestricted expenditure was £66,03812022- £58,235). 26-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 20 Restricted funds The income fvnds of the charity include reslricled funds which comprise the following unexpended balances of donations and grants held on trust for specific purposes.. Movement In funds Income Expenditure Balance at 1 January 2023 Transfers Balance at 31 December 2023 Tumour specific funds CCLG Prize General research ftjnd Adam Hay fund CCLG Senior Members Group PODC POTG The Little Princess Trust fund Treatmenl Guidelines fund TYAC Lisa Thaxler Child Cancer Smart PORT CCLG Research Network Partner Charity Neuroblastoma Nursing Group PODC- Iraq Fund Young Lives vs Can¢er Chief Nurse Funding Health Information TYAC General Restricted TYAC Research Projeds Reslricled Fund 1,573,167 364 3,180 11,222 805,435 1773.3091 1,605,293 364 5,670 11,262 2,49C> 40 5.896 954 10,980 6,200 4,510,486 614 36,632 38,105 420 6,850 2,156 6,200 614 21,632 37,786 420 18,8041 14,510,486) 115.0001 13191 652,188 1652,1881 19,0001 10,500 8,384 1,500 9,694 1,310 5.948 16,920 1,000 66,000 496 185,378 1,237,832 83,309 12,300 186,9251 112,3001 2,332 16,920 1,000 66,496 1,102,398 1320,8121 1,969,937 7,317,800 16,389.1431 2,898,594 -27-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 20 Restricted funds (Continued} Movement in funds Income Expenditure Balan¢e at 1 January 2022 Transfers Balance at 31 Dècèmbèr 2022 Tumour specific funds CCLG Prize General research fund Adam Hay fund CCLG Senior Members Group PODC POTG The Little Princess Trust fund Treatment Guidelines fund TYAC Lisa Thaxter Child Cancer Smart PORT CCLG Research Netr￿ork Partner Charity Neuroblasloma Nursing Group PODC- Iraq Fund Young Lives vs Cancer Chief Nurse Funding Health Infomiation TYAC General Reslricled TYAC Research Projects Restricted Fund 1,112,573 761,793 310 2,000 120 1301,1991 1,573,167 364 3,180 11,222 3,940 11,102 {2,7é01 4,782 1,114 210 8,350 6,200 5,639,6é9 18,225 44,132 72,867 420 5,896 {9,7371 15,639,669) 117,6111 {7,5001 139,7621 1,177 6,200 614 36,632 38,105 420 5,000 42,467 10,500 4,108 324,425 1366,8921 10.500 8,384 4,276 79,261 27,375 1,000 66.000 241,322 173,3131 110,4551 5,948 16,920 1,000 66.000 185,378 155,9441 1,331,587 7,162,015 16,524,842) 1,177 1,969,937 Transfers have been made into reslricled funds from unrestricted funds lo underwrite a ￿sh deficit on a fund. Tumour spe¢lfi¢ funds Represents income received from donors with a specrfic request that the funds are used in support of grants for a particular tumour type. CCLG Prize Represents income received from donors to fund the CCLG Prize. General research fund Represents income received from donors wth a specific request that the funds are used for research purposes. Adam Hay fund This fund has been established to continue work done by the Adam Hat's charity (which merged with CCLG in 20111 in neuroblastoma research and psychological support for children and families. CCLG Senior Members Group Represents income received from the Senior Members. Group lo be used for their aclivilies. -28-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 20 Restricted funds (Continued} PODC Represents income re￿Ived frorn donors lo be used for the Paediatric Oncology in Developing Countries IPODCI. POTG Represents income received from donors to be Ljsed for the Paediatric Oncology Trainees, Group IPOTGI. The Little Princess Trust fund Represents income received from The Little Prin￿SS Trust to fund future instalments of research grants awarded. Treatment Guidelines fund Represents a grant received for the development of rare endocrine tumour guidelines. TYAC Llsa Thaxter Represents income received for providing and supporting education and training to professionals working in the field of teenage and young adult cancer. This was previously a restricted fund in TYAC and has transferred to CCLG as part of the closure of fiAC, with the same restrictions maintained. Child Cancer Smart Represents income received for a research programme, guideline development and awareness raising focusing on earlier diagnosis of childhood cancer. PORT Represents income received for the Paediatri¢ Oncology Reference Team, a group of parents of children with cancer who review clinical trial and other ￿SearCh information to ensure it is appropriate for chikjren with cancer and their families. CCLG Research Network Partner Charity Represents income research from other charities lo fund research projects. Neuroblastoma Nursing Group Represents income received lo support the Costs of running the national neuroblastoma nursing group, a group of CCLG member nursos with a special interest in neuroblasloma. PODC- Iraq Fund Represents donations received lo specifically support work to improve the treatment and care of children with cancer in Iraq. Young Lives Ys Cancer Chief Nurse Funding Funding for the Chief Nurse role and associated projects. Health Information Funds received to support the production of health information for patients and families. TYAC G&noral Rèstrictod Fundraising and donations to support work specifically for teenagers and young adults with cancer. AC Research Income reslricled to support research projects into teenage and young adult Can￿r. Projects Restricted Fund5 Income reslricled to support specific projects including work related to research. -29-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 21 Unrestricted funds Movement in fvnds In¢om¢ Expendlture Balance at 1 January 2023 Transfers Balance at 31 Decémbèr 2023 Genoral funds 490,960 1,161,513 11,262,515) 389,958 Movement in fvnds Incom¢ Expendlture Balance at 1 January 2022 Transfers Balance at 31 Decembèr 2022 Genoral funds 591.470 1,149,760 11.249.093) 11,1771 490.960 22 Analysis of net assets between funds Unrestrl¢ted funds 2023 Restrl¢ted funds 2023 Totsl 2023 Fund balances at 31 December 2023 are represented by.. Tangible assets Current assetsllliabilitiesl Long term liabilities 31,004 358,954 31,004 5,281,877 5,640,831 12,383,283) 12,383,283) 389,958 2,898,594 3,288,552 Unrestrlctèd funds 2022 Rèstrlcted funds 2022 Total 2022 Fund balances at 31 December 2022 are represented by.. Tangiblo assets Current assetsllliabi1iliesl Long term liabilities 42,486 448,474 42,486 4,584,676 5,033,150 12,614,739) 12,614,739) 490,960 1,969,937 2,460,897 23 Evènts aftar thè rèportlng datè Thè charity was notifi￿ of an additional lagacy during th8 year. Thè timing and amount ol th8 18gacy income is uncertain as at the balance sheet date and therefore no income relating to this legacy has been recognised in these accounts. 30-

DoGusign Envelope ID.. A1B3A321k1BC944D9-AEBD-AE2D6F204600 THE CHILDREN'S CANCERAND LEUKAEMIA GROUP NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 31 DECEMBER 2023 24 Operating lease commitments Al the reporting end dale the charity had outstanding commitments for future minimum lease payments under non-cancellable operating lease5, which fall due as follows.. 2023 2022 Within one year Between tr￿0 and five years 18,397 36,530 18,397 18,397 54,927 Amounts recognised in the SOFA as an expense during the period in respect of operating lease arrangements are £36,53012022- £34,730). 25 Related party tran$a¢tlons There have been no other related party transactions in the reporting period that require disclosure in the financial statemènts, othèr than thosè notèd in note 12 to thè financial statements. 26 Cash generated from operations 2023 2022 Surplus for the year 827,655 537,840 Adjustments for.. Investment income recognised in $18lement of financi81 activities Depreciation and impairment of tangible fixed asseis 156,1771 14,074 15.9351 13,069 Movements in working capitsl.. Ilncreasel in stocks Ilncreasel in debtors Increase in creditors Increase in deferred income 12,0321 117,6031 1451,2711 11,153.2891 675,006 612,291 19,459 100 Cash generated fromllabsorbed by) operations 1,026,714 113,5271 27 Analysis of changes in net funds During the year the charity had no borrowings or obligations under finan￿ leases. The changes in net funds of the charity therefore solely comprise of cash and cash equivalents. 31