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← Foundation For Angelman Syndrome Therapeutics UK

2024-12-31-accounts

Trustees’ Annual Report for the period

From 01 January 2024 To 31 December 2024

Charity name: Foundation for Angelman Syndrome Therapeutics UK (FAST UK)

Charity registration number: 1167984

Objectives and Activities

SORP reference
Summary of the purposes of
the charity as set out in its
governing document		 Para 1.17 The objects of the CIO are:-
1. the advancement of health for the benefit
of the pubic by the provision of support
towards research into Angelman Syndrome
including their treatment and cure, and the
publication of the useful results of such
research; and
2. the relief of those in need of care,
assistance and support as a consequence
of living with Angelman Syndrome.
Summary of the main
activities in relation to those
purposes for the public
benefit, in particular, the
activities, projects or
services identified in the
accounts.		 Para 1.17 and
1.19		 Foundation for Angelman Syndrome
Therapeutics UK continues to fund the
Natural History Study for Angelman
Syndrome, with Oxford University. The
study has now been extended for another 2
years to continue gathering much needed
data as well as recruiting new patients to
take part in the study and therefore
increasing the volume of data gathered.
FAST UK strive to host events to raise
funds for the charity as well as awareness
of Angelman syndrome.
Statement confirming
whether the trustees have
had regard to the guidance
issued by the Charity
Commission on public
benefit		 Para 1.18 The trustees have had regard to the
guidance issued by the Charity
Commission on public benefit.

Additional information (optional) You may choose to include further statements where relevant about:

SORP reference
Para 1.38
Policy on grant making

Para 1.38 Policy on social investment including program related investment Para 1.38 Contribution made by volunteers Other

Achievements and Performance

SORP reference
Summary of the main
achievements of the charity,
identifying the difference the
charity’s work has made to
the circumstances of its
beneficiaries and any wider
benefits to society as a
whole.		 Para 1.20 Fund raising activities and donations
through-out the financial period have raised
income of £183,082.
FAST was founded in 2008 with an urgent
mission: to cure Angelman syndrome.
Today, with operations in the United
States, Australia, the UK, Canada, Italy,
France, Spain and Latin America, FAST is
the largest non-governmental funder of
Angelman syndrome research.
Foundation for Angelman Syndrome
Therapeutics UK has been working hard
over the past 4 years in assisting Oxford
University in the running of the Natural
History Study. At the end of 2023, the
Study has been extended by a further 2
years and will continue to be fully funded
by FAST UK.
FAST UK continue to liaise with the MHRA
and other governing bodies to ensure
preparedness for clinical trials in the UK as
and when is appropriate.

Additional information (optional) You may choose to include further statements where relevant about:
Achievements against
objectives set		 Para 1.41
Performance of fundraising
activities against objectives
set		 Para 1.41
Investment performance
against objectives		 Para 1.41
Other

Financial Review

Financial Review
Review of the charity’s
financial position at the end
of the period		 Para 1.21 At the end of the period the charity was in a
net asset position of £334,625.
Statement explaining the
policy for holding reserves
stating why they are held		 Para 1.22 There is no reserves policy, and no
reserves are held.
Amount of reserves held Para 1.22 Nil. Cash at year end was £334,625, none
of which is specifically held in reserves.
Reasons for holding zero
reserves		 Para 1.22 The charity is small and only has one part
time employee and so has minimal fixed
expenses, as such no reserves are
required. The charity has no liabilities and
so no reserves are required to cover
liabilities.
Details of fund materially in
deficit		 Para 1.24 N/A
Explanation of any
uncertainties about the
charity continuing as a going
concern		 Para 1.23 There are no uncertainties over the
charity’s ability to continue as a going
concern.

Additional information (optional) You may choose to include further statements where relevant about:

The charity’s principal
sources of funds (including
any fundraising)		 Para 1.47
Investment policy and
objectives including any
social investment policy
adopted		 Para 1.46
A description of the principal
risks facing the charity		 Para 1.46
Other

Structure, Governance and Management

Description of charity’s
trusts:
Type of governing document
(trust deed, royal charter)		 Para 1.25 Constitution
How is the charity
constituted?
(e.g unincorporated
association, CIO)		 Para 1.25 A Charitable Incorporated Organisation
Trustee selection methods
including details of any
constitutional provisions e.g.
election to post or name of
any person or body entitled
to appoint one or more
trustees		 Para 1.25 Apart from the first charity trustees, every
trustee must be appointed by a resolution
passed at a properly convened meeting of
the charity trustees.

Additional information (optional) You may choose to include further statements where relevant about:

Policies and procedures
adopted for the induction
and training of trustees		 Para 1.51
The charity’s organisational
structure and any wider
network with which the
charity works		 Para 1.51
Relationship with any related
parties		 Para 1.51
Other

Reference and Administrative details

Charity name Foundation for Angelman Syndrome Therapeutics UK
Other name the charity uses FASTUK
Registered charity number 1167984
Charity’s principal address 13 Inglethorpe Street,
London,
SW6 6NS

Names of the charity trustees who manage the charity

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20		 Trustee name Office (if any) Dates acted if not for whole
**year **		 Name of person (or body) entitled
to appoint trustee (ifany)
Tom Keogh Chair
Tamsin Keogh
Antonia Felix
Louise Prince
Julien de Bournet
Katharine Hamilton
Irina Karaseva 1 Jan - 6 Sep2024
Sarah Washbrook Appointed 25 Jun 2025

Corporate trustees – names of the directors at the date the report was approved Director name

Name of trustees holding title to property belonging to the charity

Trustee name Dates acted if not for whole year

Funds held as custodian trustees on behalf of others

Description of the assets N/A held in this capacity Name and objects of the N/A charity on whose behalf the assets are held and how this falls within the custodian charity’s objects Details of arrangements for N/A safe custody and segregation of such assets from the charity’s own assets

Additional information (optional)

Names and addresses of advisers (Optional information)

Type of
adviser
Name
Address		 Type of
adviser
Name
Address		 Type of
adviser
Name
Address
Name of chief executive or names of senior staff members (Optional information)

Exemptions from disclosure

Reason for non-disclosure of key personnel details

N/A

Other optional information

N/A

Declarations

The trustees declare that they have approved the trustees’ report above.

Signed on behalf of the charity’s trustees

Signature(s) Full name(s) Tom Keogh ~~a~~ Position (eg Secretary, Chair Chair, etc) ~~es~~ Date 24/10/2025

1167984
Period start date
To
Period end
date
31/12/2024
Foundation for Angelman Syndrome Therapeutics UK
Annual accounts for theperiod
01/01/2024
in~~———————~~
FOR ENGLAND AND WALES		 1167984
Period start date
To
Period end
date
31/12/2024
Foundation for Angelman Syndrome Therapeutics UK
Annual accounts for theperiod
01/01/2024
in~~———————~~
FOR ENGLAND AND WALES		 1167984
Period start date
To
Period end
date
31/12/2024
Foundation for Angelman Syndrome Therapeutics UK
Annual accounts for theperiod
01/01/2024
in~~———————~~
FOR ENGLAND AND WALES		 1167984
Period start date
To
Period end
date
31/12/2024
Foundation for Angelman Syndrome Therapeutics UK
Annual accounts for theperiod
01/01/2024
in~~———————~~
FOR ENGLAND AND WALES		 1167984
Period start date
To
Period end
date
31/12/2024
Foundation for Angelman Syndrome Therapeutics UK
Annual accounts for theperiod
01/01/2024
in~~———————~~
FOR ENGLAND AND WALES
Section A Statement of financial activities Section A Statement of financial activities Section A Statement of financial activities
Recommended categories by Unrestricted Restricted Endowment Prior year
activity funds income funds funds Total funds funds
£ £ £ £ £
Incoming resources (Note 3)
Income and endowments from:
Donations and legacies - - - - 212,214
Charitable activities 183,082 - - 183,082 55,434
Other trading activities - - - - -
Investments - - - -
Separate material item of income - - - - -
Other - - - - -
Total 183,082 - - 183,082 267,648
Resources expended (Note 4)
Expenditure on:
Raising funds 37,827 - - 37,827 13,076
Separate material item of expense - - - - -
Other - - -
Total 37,827 - - 37,827 13,076
Net income/(expenditure) before investment
gains/(losses) 145,256 - - 145,256 254,571
Net gains/(losses) on investments - - - - -
Net income/(expenditure) 145,256 - - 145,256 254,571
Extraordinary items - - - - -
Transfers between funds - - - - -
Other recognised gains/(losses):
Gains and losses on revaluation of fixed assets for the charity’s own
use - - - - -
Other gains/(losses) - - - - -
Net movement in funds 145,256 - - 145,256 254,571
Reconciliation of funds:
Total funds brought forward 189,369 - - 189,369 - 65,202
-
Total funds carried forward 334,625 - - 334,625 189,369

Section B Balance sheet ~~a~~

Restricted
Unrestricted
income
Endowment
Total this
Total last
funds
funds
funds
year
year
£
£
£
£
£
Current assets
Cash at bank and in hand (Note 9)
Total current assets		 334,625 - - 334,625 189,369
334,625 - - 334,625
189,369
~~pF~~
Creditors: amounts falling due within
one year (Note 7)		 - - - -
-
~~ft~~
~~
Net current assets/(liabilities) 334,625 - - 334,625
189,369
~~TF~~
Total assets less current liabilities
Creditors: amounts falling due after
one year (Note 7)		 334,625 - - 334,625 189,369
- -
-
-
-
~~————~~
~~ee ee ee eee~~
Total net assets or liabilities 334,625 - - 334,625 189,369
Funds of the Charity
Unrestricted funds
Total funds		 334,625
- 334,625
189,369
334,625 - - 334,625
189,369
~~rr~~
Signed by one or two trustees on behalf of all Date of
the trustees approval
Print Name
dd/mm/yyyy
21/10/2025
21/10/2025
Tom Keogh
Katharine Hamilton
~~i~~
~~ee~~
~~ee~~

Section C Notes to the accounts

Note 1 Basis of preparation

This section should be completed by all charities .

1.1 Basis of accounting

These accounts have been prepared under the historical cost convention with items recognised at cost or transaction value unless otherwise stated in the relevant note(s) to these accounts.

The accounts have been prepared in accordance with:

• and with* ✓ the Statement of Recommended Practice: Accounting and Reporting by Charities
preparing their accounts in accordance with the Financial Reporting Standard applicable in
the UK and Republic of Ireland (FRS 102) issued on 16 July 2014
• and with* ✓ the Financial Reporting Standard applicable in the United Kingdom and Republic of Ireland
(FRS 102)

The charity constitutes a public benefit entity as defined by FRS 102.*

✓

1.2 Going concern

If there are material uncertainties related to events or conditions that cast significant doubt on the charity's ability to continue as a going concern, please provide the following details or state "Not applicable", if appropriate:

An explanation as to those factors that
support the conclusion that the charity is a
going concern;		 The charity operates by raising donations and has no fixed costs or
liabiliites other than the commitment made to fund Oxford University
Natural History Study and there is an agreement in place with a donor to
cover any shortfall in general donations to cover this liability. As such there
is no uncertainty over the charities ability to contiue as a going concern.
Disclosure of any uncertainties that make
the going concern assumption doubtful;		 Not Applicable
Where accounts are not prepared on a
going concern basis, please disclose this
fact together with the basis on which the
trustees prepared the accounts and the
reason why the charity is not regarded as a
going concern.		 Not Applicable

1.3 Change of accounting policy

The accounts present a true and fair view and the accounting policies adopted are those outlined in note 2.

Yes* ✓ * -Tick as appropriate
No*

Please disclose:

Please disclose:
(i) the nature of the change in accounting policy; Not Applicable
(ii) the reasons why applying the new accounting policy
provides more reliable and more relevant information;
and		 Not Applicable
(iii) the amount of the adjustment for each line affected in
the current period, each prior period presented and the
aggregate amount of the adjustment relating to periods
before those presented, 3.44 FRS 102 SORP.		 Not Applicable

1.4 Changes to accounting estimates

No changes to accounting estimates have occurred in the reporting period (3.46 FRS 102 SORP).

Yes* ✓ * -Tick as appropriate
No*

Please disclose:

Please disclose:
(i) the nature of any changes; Not Applicable
(ii) the effect of the change on income and expense or
assets and liabilities for the current period; and		 Not Applicable
(iii) where practicable, the effect of the change in one or
more future periods.		 Not Applicable

1.5 Material prior year errors

No material prior year error have been identified in the reporting period (3.47 FRS 102 SORP).

Yes* ✓ * -Tick as appropriate * -Tick as appropriate
No*
Please disclose:
(i) the nature of the prior period error; Not Applicable
(ii) for each prior period presented in the accounts, the
amount of the correction for each account line item
affected; and		 Not Applicable
(iii) the amount of the correction at the beginning of the
earliest prior period presented in the accounts.		 Not Applicable

Section C Notes to the accounts (cont)

Note 2 Accounting policies

2.1 RECONCILIATION WITH PREVIOUS GENERALLY ACCEPTED ACCOUNTING PRACTICE

Please provide a description of the nature of each change There have been no changes in accounting policy in the current year. in accounting policy

Section C Notes to the accounts (cont)

Note 2 Accounting policies 2.2 INCOME

Note 2 Accounting policies
2.2 INCOME
This standard list of accounting policies has been applied by the charity except for those ticked "No" or "N/a". Where a
different or additional policy has been adopted then this is detailed in the box below.		 Yes
No
N/a
Recognition of income
Donated services and facilities that are consumed immediately are recognised as
income with an equivalent amount recognised as an expense under the appropriate
heading in the SOFA.
The cost of any stock of goods donated for distribution to beneficiaries is deemed to be
the fair value of those gifts at the time of their receipt and they are recognised on receipt.
In the reporting period in which the stocks are distributed, they are recognised as an
expense at the carrying amount of the stocks at distribution.
Donated services and
facilities
Donated services and facilities are included in the SOFA when received at the value of
the gift to the charity provided the value of the gift can be measured reliably.
These are included in the Statement of Financial Activities (SoFA) when:
• the charity becomes entitled to the resources;
· it is more likely than not that the trustees will receive the resources; and
• the monetary value can be measured with sufficient reliability.
Donated goods
Contractual income and
performance related
grants
Offsetting
There has been no offsetting of assets and liabilities, or income and expenses, unless required or
permitted by the FRS 102 SORP or FRS 102.
Grants and donations
Grants and donations are only included in the SoFA when the general income
recognition criteria are met (5.10 to 5.12 FRS102 SORP).
This is only included in the SoFA once the charity has provided the related goods or
services or met the performance related conditions.
Donated goods are measured at fair value (the amount for which the asset could be
exchanged) unless impractical to do so.
In the case of performance related grants, income must only be recognised to the extent
that the charity has provided the specified goods or services as entitlement to the grant
only occurs when the performance related conditions are met (5.16 FRS 102 SORP).
Legacies
Legacies are included in the SOFA when receipt is probable, that is, when there has
been grant of probate, the executors have established that there are sufficient assets in
the estate and any conditions attached to the legacy are either within the control of the
charity or have been met.
Government grants
The charity has received government grants in the reporting period
Tax reclaims on
donations and gifts
Gift Aid receivable is included in income when there is a valid declaration from the donor.
Any Gift Aid amount recovered on a donation is considered to be part of that gift and is
treated as an addition to the same fund as the initial donation unless the donor or the
terms of the appeal have specified otherwise.
Gifts in kind for use by the charity are included in the SoFA as income from donations
when receivable.
Donated goods for resale are measured at fair value on initial recognition, which is the
expected proceeds from sale less the expected costs of sale, and recognised in 'Income
from other trading activities' with the corresponding stock recognised in the balance
sheet. On its sale the value of stock is charged against 'Income from other trading
activities' and the proceeds from sale are also recognised as 'Income from other trading
activities'.
Goods donated for on-going use by the charity are recognised as tangible fixed assets
and included in the SoFA as incoming resources when receivable.
✓
Yes
No
N/a
✓
Yes
No
N/a
✓ ✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Support costs include central functions and have been allocated to activity cost
categories on a basis consistent with the use of resources, eg allocating property costs
by floor areas, or per capita, staff costs by the time spent and other costs by their usage.
Grants with performance
conditions
Where the charity gives a grant with conditions for its payment being a specific level of
service or output to be provided, such grants are only recognised in the SoFA once the
recipient of the grant has provided the specified service or output.
Grants payable without
performance conditions
Where there are no conditions attaching to the grant that enables the donor charity to
realistically avoid the commitment, a liability for the full funding obligation must be
recognised.
Basic financial
instruments
This includes any realised or unrealised gains or losses on the sale of investments and
any gain or loss resulting from revaluing investments to market value at the end of the
year.
Income from interest,
royalties and dividends
This is included in the accounts when receipt is probable and the amount receivable can
be measured reliably.
Income from membership
subscriptions
Membership subscriptions received in the nature of a gift are recognised in Donations
and Legacies.
Membership subscriptions which gives a member the right to buy services or other
benefits are recognised as income earned from the provision of goods and services as
income from charitable activities.
2.3 EXPENDITURE AND LIABILITIES
Liability recognition
Liabilities are recognised where it is more likely than not that there is a legal or
constructive obligation committing the charity to pay out resources and the amount of the
obligation can be measured with reasonable certainty.
Investment gains and
losses
The charity accounts for basic financial instruments on initial recognition as per
paragraph 11.7 FRS102 SORP. Subsequent measurement is as per paragraphs 11.17
to 11.19, FRS102 SORP.
Governance and support
costs
Support costs have been allocated between governance costs and other support.
Governance costs comprise all costs involving public accountability of the charity and its
compliance with regulation and good practice.
Settlement of insurance
claims
Insurance claims are only included in the SoFA when the general income recognition
criteria are met (5.10 to 5.12 FRS102 SORP) and are included as an item of other
income in the SoFA.
Support costs
The charity has incurred expenditure on support costs.
Volunteer help
The value of any voluntary help received is not included in the accounts but is described
in the trustees’ annual report.
Redundancy cost
The charity made no redundancy payments during the reporting period.
Deferred income
No material item of deferred income has been included in the accounts.
Creditors
The charity has creditors which are measured at settlement amounts less any trade
discounts
Provisions for liabilities
A liability is measured on recognition at its historical cost and then subsequently
measured at the best estimate of the amount required to settle the obligation at the
reporting date		 Yes
No
N/a		 Yes
No
N/a		 Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓ ✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓

2.4 ASSETS

Intangible fixed assets
Heritage assets
Current asset
investments
The charity has has investments which it holds for resale or pending their sale and cash and
cash equivalents with a maturity date less than one year. These include cash on deposit and
cash equivalents with a maturity date of less than one year held for investment purposes rather
than to meet short term cash commitments as they fall due.
They are valued at fair value except where they qualify as basic financial instruments.
Debtors
Debtors (including trade debtors and loans receivable) are measured on initial recognition at
settlement amount after any trade discounts or amount advanced by the charity. Subsequently,
they are measured at the cash or other consideration expected to be received.
Stocks and work in
progress
Stocks held for sale as part of non-charitable trade are measured at the lower or cost or net
realisable value.
Goods or services provided as part of a charitable activity are measured at net realisable value
based on the service potential provided by items of stock.
Work in progress is valued at cost less any foreseeable loss that is likely to occur on the contract.
They are valued at cost.
Investments
Fixed asset investments in quoted shares, traded bonds and similar investments are
valued at initially at cost and subsequently at fair value (their market value) at the year
end. The same treatment is applied to unlisted investments unless fair value cannot be
measured reliably in which case it is measured at cost less impairment.
Investments held for resale or pending their sale and cash and cash equivalents with a
maturity date of less than 1 year are treated as current asset investments
The charity has intangible fixed assets, that is, non-monetary assets that do not have
physical substance but are identifiable and are controlled by the charity through custody
or legal rights. The amortisation rates and methods used are disclosed in note 9.5
They are valued at cost.
The charity has heritage assets, that is, non-monetary assets with historic, artistic,
scientific, technological, geophysical or environmental qualities that are held and
maintained principally for their contribution to knowledge and culture. The depreciation
rates and methods used as disclosed in note 9.6.1.4.
Tangible fixed assets for
use by charity
The depreciation rates and methods used are disclosed in note 9.2.
They are valued at cost.
These are capitalised if they can be used for more than one year, and cost at least		 Intangible fixed assets
Heritage assets
Current asset
investments
The charity has has investments which it holds for resale or pending their sale and cash and
cash equivalents with a maturity date less than one year. These include cash on deposit and
cash equivalents with a maturity date of less than one year held for investment purposes rather
than to meet short term cash commitments as they fall due.
They are valued at fair value except where they qualify as basic financial instruments.
Debtors
Debtors (including trade debtors and loans receivable) are measured on initial recognition at
settlement amount after any trade discounts or amount advanced by the charity. Subsequently,
they are measured at the cash or other consideration expected to be received.
Stocks and work in
progress
Stocks held for sale as part of non-charitable trade are measured at the lower or cost or net
realisable value.
Goods or services provided as part of a charitable activity are measured at net realisable value
based on the service potential provided by items of stock.
Work in progress is valued at cost less any foreseeable loss that is likely to occur on the contract.
They are valued at cost.
Investments
Fixed asset investments in quoted shares, traded bonds and similar investments are
valued at initially at cost and subsequently at fair value (their market value) at the year
end. The same treatment is applied to unlisted investments unless fair value cannot be
measured reliably in which case it is measured at cost less impairment.
Investments held for resale or pending their sale and cash and cash equivalents with a
maturity date of less than 1 year are treated as current asset investments
The charity has intangible fixed assets, that is, non-monetary assets that do not have
physical substance but are identifiable and are controlled by the charity through custody
or legal rights. The amortisation rates and methods used are disclosed in note 9.5
They are valued at cost.
The charity has heritage assets, that is, non-monetary assets with historic, artistic,
scientific, technological, geophysical or environmental qualities that are held and
maintained principally for their contribution to knowledge and culture. The depreciation
rates and methods used as disclosed in note 9.6.1.4.
Tangible fixed assets for
use by charity
The depreciation rates and methods used are disclosed in note 9.2.
They are valued at cost.
These are capitalised if they can be used for more than one year, and cost at least		 Yes
No
N/a		 Yes
No
N/a		 Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
Yes
No
N/a
✓
POLICIES ADOPTED
ADDITIONAL TO OR
DIFFERENT FROM
THOSE ABOVE		 Not Applicable

Section C Notes to the accounts (cont)

Note 3 Analysis of income

Note 3 Analysis of income Analysis of income Analysis of income Analysis of income Analysis of income Analysis of income Analysis of income
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
Prior year
£
£
Donations andgifts
- - - - 212,214
- - - - -
Total
- - - - 212,214
Fundraisingand Donations
183,082
- - 183,082 55,434
- - - - -
- - - - -
Total 183,082
- - 183,082 55,434
183,082
- - 183,082 267,648
Other information:
TOTAL INCOME
Analysis
Donations
and legacies:
Charitable
activities:		 Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
Prior year
£
£
Analysis
Donations andgifts - - - - 212,214
- - - - -
Total - - - - 212,214
Fundraisingand Donations 183,082 - - 183,082 55,434
- - - - -
- - - - -
183,082 - - 183,082 55,434
183,082 - - 183,082 267,648

All income in the prior year was unrestricted except for: (please provide description and amounts)

All income in the current year and prior year was unrestricted. In the prior year a donation of £212,214 was received and whilst not restricted, the donation was designated for funding the charity's commitment to fund the Oxford University Natural History Study.

Where any endowment fund is converted into income in the reporting period, please give the reason for the conversion.

Not Applicable

Where any endowment fund is converted into income in the prior period, please give the reason for the conversion.

Not Applicable

Within the income items above the following items are material: (please disclose the nature, amount and any prior year amounts)

Material donations were received in the prior year to fund the the Oxford University Natural History Study commitment.

Section C Notes to the accounts (cont)

Note 4 Analysis of expenditure

Analysis
Expenditure on raising funds:		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total funds
£
£
This year
Last year
Incurred seeking donations 562 - - 562 562 - - 562
Staging fundraising events 25,007 - - 25,007 12,232 12,232
Salary and Pension 10,151 10,151
Website cost 1,000 1,000
Advertising, marketing, direct mail, publicity
and administration		 1,106 - - 1,106 223 - - 223
- - - - - - - -
Separate material item of expense
Total expenditure on raising funds		 37,827 - - 37,827 13,016 - - 13,016
- - - -
-		 - - -
- - - - - - - -
- - - - - - - -
TOTAL EXPENDITURE
Total		 - - - - - - - -
37,827 - - 37,827 13,016 - - 13,016

Section C Notes to the accounts

Note 5 Details of certain items of expenditure

Fees for examination of the accounts

Other fees (for example: financial advice, consultancy, accountancy services) paid to
the independent examiner
Independent examiner’s fees
Assurance services other than audit or independent examination
Tax advisory fees		 This year
£		 Last year
£
- -
- -
- -
- -

Section C Notes to the accounts (cont)

Note 6 Grantmaking

This year:

6.1 Analysis of grants made

6.1 Analysis of grants made
Analysis Grants to
institutions		 Grants to individuals Support costs Total
£ £
Oxford UniversityNatural HistoryStudy - - - -
Total - - - -

6.2 Grants made to institutions

The charity has not made any grants in the current year.

Names of institution Purpose Total amount of
grantspaid £
TOTAL GRANTS PAID
Total grants to institutions in reporting period		 -
-

Last year:

6.3 Analysis of grants made

Last year:
6.3 Analysis ofgrants made
Analysis Grants to
institutions		 Grants to individuals Support costs
£		 Total
£
Oxford UniversityNatural HistoryStudy - - - -
Total - - - -

6.4 Grants made to institutions

My charity has made no additional grants in the year

Names of institution Purpose Total amount of
grantspaid £
TOTAL GRANTS PAID
Total grants paid to institutions in reporting period		 -
-

Section C Notes to the accounts (cont)

Note 7 Creditors and accruals

7.1 Analysis of creditors

Accruals for grants payable

Total Amounts falling due within
oneyear		 Amounts falling due within
oneyear		 Amounts falling due after
more than oneyear		 Amounts falling due after
more than oneyear
This year
£		 Last year
£		 This year
£		 Last year
£
- - - -
- - - -

Section C Notes to the accounts (cont)

Note 8 Reconciliation of funding commitments

8.1 Movements in funding commitment during the period

Balance at the start of the reporting period Amounts added in current period Amounts paid in the current period Balance at the end of the reporting period

This year
£		 Last year
£
- 495,622
-
-
- - 495,622
- -
8.2 Please provide:
- a brief description of any obligations on the balance
sheet and the expected amount and timing of
resulting payments;
- an indication of the uncertainties about the amount
or timing of those outflows; and
- the amount of any expected reimbursement, stating
the amount of any asset that has been recognised for
that expected reimbursement.
8.3 Where unrestricted funds have been designated
to a fund commitment, please disclose the nature of
any amounts designated and the likely timing of that
expenditure.		 Thisyear
Lastyear		 Thisyear
Lastyear

N/A there are no obligations on the
balance sheet		 N/A The only obligation of the charity
relates to the funding commitment made
to Oxford University for the Natural
History Study. Of the £1,077,103
committed £0 remained due at the end of
the reporting period.
Not Applicable. Not Applicable, the payments are to be
made in accordance with the budget
agreed within the commitment agreement.
No amounts are expected to be
reimbursed and no assets have been
recongnised in relation to any expected
reimbursments.		 No amounts are expected to be
reimbursed and no assets have been
recongnised in relation to any expected
reimbursments.
The charity has no commitments. The charity's only funding commitment
related to to the Oxford University Natural
History Study. No formal designation of
unrestricted funds was made and these
amounts were paid out of unrestricted
funds. There were no funding
commitments at the end of the reporting
period.

Section C Notes to the accounts (cont)

Note 9 Cash at bank and in hand

Cash at bank and on hand Other Total

This year
£		 Last year
£
334,625 189,369
- -
334,625 189,369

Section C Notes to the accounts (cont)

Note 10 Events after the end of the reporting period

Please provide details of the nature of the event

Provide an estimate of the financial effect of the event or a statement that such an estimate cannot be made

This year Last year There were no material events after the There were no material events after end of the reporting period. the end of the reporting period. N/A N/A

Section C Notes to the accounts (cont)

Note 11 Transactions with trustees and related parties

11.1 Trustee remuneration and benefits

This year

None of the trustees have been paid any remuneration or received any other benefits from an employment with their charity or a related entity (True or False)

Last year

None of the trustees have been paid any remuneration or received any other benefits from an employment with their charity or a related entity (True or False)

TRUE TRUE

11.2 Trustees' expenses

No trustee expenses have been incurred (True or False)

TRUE

11.3 Transaction(s) with related parties

Please give details of any transaction undertaken by (or on behalf of) the charity in which a related party has a material interest, including where funds have been held as agent for related parties. If there are no such transactions, please enter 'true' in the box provided.

This year

There have been no related party transactions in the reporting period (True or False) There have been no related party transactions in the reporting period (True or False) TRUE
In relation to the transactions above, please provide the
terms and conditions, including any security and the nature
of any payment (consideration) to be provided in settlement.		 Not Applicable
For any related party, please provide details of any
guarantees given or received.
Not Applicable

Last year

Last year Last year
There have been no related party transactions in the reporting period (True or False) TRUE
For any related party, please provide details of any
guarantees given or received.
In relation to the transactions above, please provide the
terms and conditions, including any security and the nature
of any payment (consideration) to be provided in settlement.
Not Applicable
Not Applicable.

Section C Notes to the accounts (cont)

Note 12 Additional Disclosures

The following are significant matters which are not covered in other notes and need to be included to provide a proper understanding of the accounts. If there is insufficient room here, please add a separate sheet.

No additional significant matters to note.

CHARITY COMMISSION FOR ENGLAND ANO WALES Independent examiner's report on the accounts Section A Independent Examiner's Report Report to the trustees Foundation for Angelman Syndrome Therapeutics UK On accounts for the year ended 3111212024 Charity no (if any) 1167984 Set out on pages 1-21 I report to the trustees on my examination of the accounts of the above charity ("the Trust.) for the year ended 3111212024. Responsibilities and basis of report As the charity's trustees, you are responsible for the preparation of the accounts in accordance with the requirements of the Charities Act 2011 ("the Act"). I report in respect of my examination of the Trust's accounts carried out under section 145 of the 2011 Act and in carrying out my examination. I have followed all the applicable Directions given by the Charity Commission under section 145(5)(b) of the Act. Independent I have completed my examination. I confirm that no material matters have examinerfs statement come to my attention in connection with the examination (other than that disclosed below ') which gives me cause to believe that in, any material resp8Ct: the accounting records were not kept in accordance with section 130 of the Charities Act. or the accounts did not accord with the accounting records. or the accounts did not comply with the applicable requirements conceming the form and content of accounts set out in the Charities {Accounts and Reports) Regulations 2008 other than any requirement that the accounts give a 'true and fair, view which is not a matter considered as part of an independent examination. I have no concerns and have come across no other matters in connection with the examination to which attention should be drawn in this report in order to enable a proper understanding of the accounts to be reached. Plea ete the words in the brackets if they do not apply. Signed: Date: 702i- Name: dT4icL Relevant professional qualification{s) or body (if any): Address: A LL"UJ LC-LL k SAI

Section B Disclosure Only complete if the examiner needs to highlight material matters of concern (see CC32, Independent examination of charity accounts: directions and guidance for examiners). Give here brief details of any items that the examiner wishes to disclose.