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2022-12-31-accounts

Trustees’ Annual Report for the period

From 01 January 2022 To 31 December 2022

Charity name: Foundation for Angelman Syndrome Therapeutics UK (FAST UK)

Charity registration number: 1167984

Objectives and Activities

SORP reference
Summary of the purposes of
the charity as set out in its
governing document		 Para 1.17 The objects of the CIO are:-
1. the advancement of health for the benefit
of the pubic by the provision of support
towards research into Angelman Syndrome
including their treatment and cure, and the
publication of the useful results of such
research; and
2. the relief of those in need of care,
assistance and support as a consequence
of living with Angelman Syndrome.
Summary of the main
activities in relation to those
purposes for the public
benefit, in particular, the
activities, projects or
services identified in the
accounts.		 Para 1.17 and
1.19		 Foundation for Angelman Syndrome
Therapeutics UK has been working very
hard over the last year to assist Oxford
University in the putting together a Natural
History Study for Angelman Syndrome. The
study is about to start recruiting patients
and is fully funded by FAST.
Statement confirming
whether the trustees have
had regard to the guidance
issued by the Charity
Commission on public
benefit		 Para 1.18 The trustees have had regard to the
guidance issued by the Charity
Commission on public benefit.

Additional information (optional) You may choose to include further statements where relevant about:

SORP reference Para 1.38 Policy on grant making Para 1.38 Policy on social investment including program related investment

Para 1.38 Contribution made by volunteers Other

Achievements and Performance

SORP reference
Summary of the main
achievements of the charity,
identifying the difference the
charity’s work has made to
the circumstances of its
beneficiaries and any wider
benefits to society as a
whole.		 Para 1.20 Fund raising activities and donations
through-out the financial period have raised
income of £328,007.
FAST was founded in 2008 with an urgent
mission: to cure Angelman syndrome.
Today, with operations in the United
States, Australia, the UK, Canada, Italy,
France, Spain and Latin America, FAST is
the largest non-governmental funder of
Angelman syndrome research.
During the year, FAST has been continuing
to fund the Natural History Study in
conjunction with Oxford University.
Funding of £293,610 has been provided in
the year ended 31 December 2022, with a
further £495,652 committed over the next 4
years.
In 2023, FAST UK completed its aim in
recruiting 40 patients to take part in the
Oxford-based Natural History Study (NHS).
The NHS aims to enhance understanding
of Angelman Syndrome, aid UK healthcare
preparedness for forthcoming therapies,
and contribute to diagnostic tools,
treatments, and successful clinical trial
designs. This initiative, funded by FAST
UK, strives to observe patients over time,
establish objective assessment methods,
connect research to patient needs, facilitate
drug development, recruit patients for trials,
prepare NHS infrastructure, and foster
reliable diagnostic tool creation.
FAST UK continue to liaise with the MHRA
and other governing bodies to ensure
preparedness for clinical trials in the UK as
and when is appropriate.

Additional information (optional) You may choose to include further statements where relevant about:

Achievements against
objectives set		 Para 1.41
Performance of fundraising
activities against objectives
set		 Para 1.41
Investment performance
against objectives		 Para 1.41
Other

Financial Review

Financial Review
Review of the charity’s
financial position at the end
of the period		 Para 1.21 At the end of the period the charity was in a
net liability position of £65,202. This results
from the commitment made to fund the
Oxford University Natural History Study.
There is an agreement in place with a
private donor to fund any shortfall in the
charity’s ability to fund this commitment
made.
Statement explaining the
policy for holding reserves
statingwhy they areheld		 Para 1.22 There is no reserves policy, and no
reserves are held.
Amount of reserves held Para 1.22 Nil. Cash at year end was £430,360, none
of which is specificallyheldin reserves.
Reasons for holding zero
reserves		 Para 1.22 The charity is small and has no fixed costs
or expenses, as such no reserves are
required. As there is an agreement in
place to fund any shortfalls in the funding
commitment to Oxford University for the
Natural History Study, no reserves are
required to cover this funding liability and
the charity has no other liabilities.
Details of fund materially in
deficit		 Para 1.24 In the current period the charity is
materially in a liability position as a result of
the funding commitment made to fund the
Oxford University Natural History Study.
The charity has an agreement with an
individual donor to fund any shortfalls in the
charity’s ability to meet the funding
commitments as theyfalldue.
Explanation of any
uncertainties about the
charity continuing as a going
concern		 Para 1.23 There are no uncertainties over the
charity’s ability to continue as a going
concern. As noted above, whilst the charity
is in a net liability position there is an
agreement in place with a donor to fund
any shortfalls in the commitments as they
fall due.

Additional information (optional) You may choose to include further statements where relevant about:

The charity’s principal
sources of funds (including
any fundraising)		 Para 1.47
Investment policy and
objectives including any
social investment policy
adopted		 Para 1.46
A description of the principal
risks facing the charity		 Para 1.46

Other

Structure, Governance and Management

Description of charity’s
trusts:
Type of governing document
(trust deed, royal charter)		 Para 1.25 Constitution
How is the charity
constituted?
(e.g unincorporated
association, CIO)		 Para 1.25 A Charitable Incorporated Organisation
Trustee selection methods
including details of any
constitutional provisions e.g.
election to post or name of
any person or body entitled
to appoint one or more
trustees		 Para 1.25 Apart from the first charity trustees, every
trustee must be appointed by a resolution
passed at a properly convened meeting of
the charity trustees.

Additional information (optional) You may choose to include further statements where relevant about:

Policies and procedures
adopted for the induction
and training of trustees		 Para 1.51
The charity’s organisational
structure and any wider
network with which the
charity works		 Para 1.51
Relationship with any related
parties		 Para 1.51
Other

Reference and Administrative details

Charity name Foundation for Angelman Syndrome Therapeutics UK
Other name the charity uses FASTUK
Registered charity number 1167984
Charity’s principal address 13 Inglethorpe Street,
London,
SW6 6NS

Names of the charity trustees who manage the charity

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20		 Trustee name Office (if any) Dates acted if not for whole
**year **		 Name of person (or body) entitled
to appoint trustee (ifany)
Tom Keogh Chair
Tamsin Keogh
Antonia Felix
Louise Prince
Julien de Bournet
Katharine Hamilton
Irina Karaseva

– Corporate trustees names of the directors at the date the report was approved

Director name

Name of trustees holding title to property belonging to the charity

Trustee name Dates acted if not for whole year

Funds held as custodian trustees on behalf of others

Description of the assets N/A held in this capacity Name and objects of the N/A charity on whose behalf the assets are held and how this falls within the custodian charity’s objects Details of arrangements for N/A safe custody and segregation of such assets from the charity’s own assets

Additional information (optional)

Names and addresses of advisers (Optional information)

Type of
adviser
Name
Address		 Type of
adviser
Name
Address		 Type of
adviser
Name
Address
Name of chief executive or names of senior staff members (Optional information)

Exemptions from disclosure

Reason for non-disclosure of key personnel details

N/A

Other optional information

N/A

Declarations

The trustees declare that they have approved the trustees’ report above.

Signed on behalf of the charity’s trustees

Signature(s)
Full name(s)
Position (eg Secretary,
Chair, etc)
Date
Tom Keogh

Chair
26/10/2023
26/10/2023
1167984
Period start date
To
Period end
date
31/12/2022
Foundation for Angelman Syndrome Therapeutics UK
Annual accounts for the period
01/01/2022		 1167984
Period start date
To
Period end
date
31/12/2022
Foundation for Angelman Syndrome Therapeutics UK
Annual accounts for the period
01/01/2022
Section A Statement of financial activities
Recommended categories by
activity
Incoming resources (Note 3)
Income and endowments from:
Donations and legacies
Charitable activities
Other trading activities
Investments
Separate material item of income
Other
Resources expended (Note 4)
Expenditure on:
Raising funds
Separate material item of expense
Other
Net gains/(losses) on investments
Extraordinary items
Other gains/(losses)
Reconciliation of funds:
Total
Net movement in funds
Total funds brought forward
Total funds carried forward
Total
Net income/(expenditure) before investment
gains/(losses)
Net income/(expenditure)
Transfers between funds
Other recognised gains/(losses):
Gains and losses on revaluation of fixed assets for the charity’s
own use		 Unrestricted
funds
Restricted
income funds
Endowment
funds
Total funds
Prior year
funds
£
£
£
£
£
328,007
-
-
328,007
317,810
-
-
-
-
3,430
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
328,007
-
-
328,007
321,240
5,544
-
-
5,544
2,797
-
-
-
-
-
-
-
-
5,544
-
-
5,544
2,797
322,463
-
-
322,463
318,443
-
-
-
-
-
322,463
-
-
322,463
318,443
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
322,463
-
-
322,463
318,443
387,665
-
-
-
387,665
-
706,108
-
65,202
-
-
-
65,202
-
387,665
-

Section B Balance sheet

Current assets
Cash at bank and in hand (Note 9)
Total current assets
Creditors: amounts falling due within
one year (Note 7)
Net current assets/(liabilities)
Total assets less current liabilities
Creditors: amounts falling due after
one year (Note 7)
Total net assets or liabilities
Funds of the Charity
Unrestricted funds
Total funds
Signed by one or two trustees on behalf of all
the trustees		 Unrestricted
funds
Restricted
income
funds
Endowment
funds
Total this
year
Total last
year
£
£
£
£
£
430,360 - - 430,360
401,507
430,360 - - 430,360
401,507

283,348 - - 283,348
293,590
147,012 - - 147,012
107,917
147,012
- - 147,012
107,917
212,214 -
-
212,214
495,582
- 65,202 - - - 65,202 - 387,665
- 65,202
- - 65,202
387,665
-
- 65,202 - - - 65,202
387,665
-
Date of
approval
dd/mm/yyyy
Thomas Keogh
Katharine Hamilton
Print Name
16/10/2023
16/10/2023

Section C Notes to the accounts

Note 1 Basis of preparation

This section should be completed by all charities .

1.1 Basis of accounting

These accounts have been prepared under the historical cost convention with items recognised at cost or transaction value unless otherwise stated in the relevant note(s) to these accounts.

The accounts have been prepared in accordance with:

the Statement of Recommended Practice: Accounting and Reporting by Charities
• and with* preparing their accounts in accordance with the Financial Reporting Standard
applicable in the UK and Republic of Ireland (FRS 102) issued on 16 July 2014
• and with* the Financial Reporting Standard applicable in the United Kingdom and Republic of
Ireland (FRS 102)

The charity constitutes a public benefit entity as defined by FRS 102.*

1.2 Going concern

If there are material uncertainties related to events or conditions that cast significant doubt on the charity's ability to continue as a going concern, please provide the following details or state "Not applicable", if appropriate:

An explanation as to those factors that The charity operates by raising donations and has no fixed costs or
support the conclusion that the charity is
a going concern;		 liabiliites other than the commitment made to fund Oxford University
Natural History Study and there is an agreement in place with a donor to
cover any shortfall in general donations to cover this liability. As such there
is no uncertainty over the charities ability to contiue as a going concern.
Disclosure of any uncertainties that make Not Applicable
the going concern assumption doubtful;
Where accounts are not prepared on a Not Applicable
going concern basis, please disclose this
fact together with the basis on which the
trustees prepared the accounts and the
reason why the charity is not regarded as
a going concern.

1.3 Change of accounting policy

The accounts present a true and fair view and the accounting policies adopted are those outlined in note 2.

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Yes
 -Tick as appropriate
No
Please disclose:
(i) the nature of the change in accounting policy; Not Applicable
(ii) the reasons why applying the new accounting policy Not Applicable
provides more reliable and more relevant information;
and
(iii) the amount of the adjustment for each line affected Not Applicable
in the current period, each prior period presented and
the aggregate amount of the adjustment relating to
periods before those presented, 3.44 FRS 102 SORP.
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1.4 Changes to accounting estimates

No changes to accounting estimates have occurred in the reporting period (3.46 FRS 102 SORP).

Yes*
No* * -Tick as appropriate

Please disclose:

(i) the nature of any changes; Not Applicable
(ii) the effect of the change on income and expense or Not Applicable
assets and liabilities for the current period; and
(iii) where practicable, the effect of the change in one or Not Applicable
more future periods.

1.5 Material prior year errors

No material prior year error have been identified in the reporting period (3.47 FRS 102 SORP).

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Yes
 -Tick as appropriate
No
Please disclose:
(i) the nature of the prior period error; Not Applicable
(ii) for each prior period presented in the accounts, the Not Applicable
amount of the correction for each account line item
affected; and
(iii) the amount of the correction at the beginning of the Not Applicable
earliest prior period presented in the accounts.
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Section C Notes to the accounts (cont)

Note 2 Accounting policies

2.1 RECONCILIATION WITH PREVIOUS GENERALLY ACCEPTED ACCOUNTING PRACTICE

Please provide a description of the nature of each change There have been no changes in accounting policy in the current year. in accounting policy

Section C Notes to the accounts (cont)

Note 2 Accounting policies 2.2 INCOME

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This standard list of accounting policies has been applied by the charity except for those ticked "No" or "N/a". Where a
different or additional policy has been adopted then this is detailed in the box below.
Recognition of income These are included in the Statement of Financial Activities (SoFA) when:
 the charity becomes entitled to the resources;
· it is more likely than not that the trustees will receive the resources; and Yes No N/a
 the monetary value can be measured with sufficient reliability. 
Yes No N/a
There has been no offsetting of assets and liabilities, or income and expenses, unless required
Offsetting or permitted by the FRS 102 SORP or FRS 102. 
Yes No N/a
Grants and donations are only included in the SoFA when the general income
Grants and donations recognition criteria are met (5.10 to 5.12 FRS102 SORP). 
Yes No N/a
In the case of performance related grants, income must only be recognised to the extent
that the charity has provided the specified goods or services as entitlement to the grant
only occurs when the performance related conditions are met (5.16 FRS 102 SORP). 
Legacies Legacies are included in the SOFA when receipt is probable, that is, when there has Yes No N/a
been grant of probate, the executors have established that there are sufficient assets in
the estate and any conditions attached to the legacy are either within the control of the 
charity or have been met.
Yes No N/a
Government grants The charity has received government grants in the reporting period

Gift Aid receivable is included in income when there is a valid declaration from the
Tax reclaims on donor. Any Gift Aid amount recovered on a donation is considered to be part of that gift Yes No N/a
donations and gifts and is treated as an addition to the same fund as the initial donation unless the donor or

the terms of the appeal have specified otherwise.
Yes No N/a
Contractual income and
This is only included in the SoFA once the charity has provided the related goods or
performance related services or met the performance related conditions. 
grants
Yes No N/a
Donated goods are measured at fair value (the amount for which the asset could be
Donated goods
exchanged) unless impractical to do so. 
The cost of any stock of goods donated for distribution to beneficiaries is deemed to be
Yes No N/a
the fair value of those gifts at the time of their receipt and they are recognised on receipt.
In the reporting period in which the stocks are distributed, they are recognised as an 
expense at the carrying amount of the stocks at distribution.
Donated goods for resale are measured at fair value on initial recognition, which is the
expected proceeds from sale less the expected costs of sale, and recognised in 'Income
Yes No N/a
from other trading activities' with the corresponding stock recognised in the balance
sheet. On its sale the value of stock is charged against 'Income from other trading
activities' and the proceeds from sale are also recognised as 'Income from other trading 
activities'.
Yes No N/a
Goods donated for on-going use by the charity are recognised as tangible fixed assets
and included in the SoFA as incoming resources when receivable. 
Yes No N/a
Gifts in kind for use by the charity are included in the SoFA as income from donations
when receivable. 
Yes No N/a
Donated services and Donated services and facilities are included in the SOFA when received at the value of
facilities the gift to the charity provided the value of the gift can be measured reliably. 
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Yes No N/a 

Donated services and facilities that are consumed immediately are recognised as income with an equivalent amount recognised as an expense under the appropriate heading in the SOFA.

Settlement of insurance
claims
Insurance claims are only included in the SoFA when the general income recognition
criteria are met (5.10 to 5.12 FRS102 SORP) and are included as an item of other
income in the SoFA.
Support costs
The charity has incurred expenditure on support costs.
Volunteer help
The value of any voluntary help received is not included in the accounts but is described
in the trustees’ annual report.
Redundancy cost
The charity made no redundancy payments during the reporting period.
Deferred income
No material item of deferred income has been included in the accounts.
Creditors
The charity has creditors which are measured at settlement amounts less any trade
discounts
Provisions for liabilities
A liability is measured on recognition at its historical cost and then subsequently
measured at the best estimate of the amount required to settle the obligation at the
reporting date
This includes any realised or unrealised gains or losses on the sale of investments and
any gain or loss resulting from revaluing investments to market value at the end of the
year.
Income from interest,
royalties and dividends
This is included in the accounts when receipt is probable and the amount receivable can
be measured reliably.
Income from membership
subscriptions
Membership subscriptions received in the nature of a gift are recognised in Donations
and Legacies.
Membership subscriptions which gives a member the right to buy services or other
benefits are recognised as income earned from the provision of goods and services as
income from charitable activities.
2.3 EXPENDITURE AND LIABILITIES
Liability recognition
Liabilities are recognised where it is more likely than not that there is a legal or
constructive obligation committing the charity to pay out resources and the amount of
the obligation can be measured with reasonable certainty.
Investment gains and
losses
The charity accounts for basic financial instruments on initial recognition as per
paragraph 11.7 FRS102 SORP. Subsequent measurement is as per paragraphs 11.17
to 11.19, FRS102 SORP.
Governance and support
costs
Support costs have been allocated between governance costs and other support.
Governance costs comprise all costs involving public accountability of the charity and its
compliance with regulation and good practice.
Support costs include central functions and have been allocated to activity cost
categories on a basis consistent with the use of resources, eg allocating property costs
by floor areas, or per capita, staff costs by the time spent and other costs by their usage.
Grants with performance
conditions
Where the charity gives a grant with conditions for its payment being a specific level of
service or output to be provided, such grants are only recognised in the SoFA once the
recipient of the grant has provided the specified service or output.
Grants payable without
performance conditions
Where there are no conditions attaching to the grant that enables the donor charity to
realistically avoid the commitment, a liability for the full funding obligation must be
recognised.
Basic financial
instruments		 Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

Yes
No
N/a

2.4 ASSETS

Tangible fixed assets for These are capitalised if they can be used for more than one year, and cost at least use by charity

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Yes No N/a
They are valued at cost.

The depreciation rates and methods used are disclosed in note 9.2.
Intangible fixed assets The charity has intangible fixed assets, that is, non-monetary assets that do not have Yes No N/a
physical substance but are identifiable and are controlled by the charity through custody
or legal rights. The amortisation rates and methods used are disclosed in note 9.5 
Yes No N/a
They are valued at cost.

Heritage assets The charity has heritage assets, that is, non-monetary assets with historic, artistic, Yes No N/a
scientific, technological, geophysical or environmental qualities that are held and
maintained principally for their contribution to knowledge and culture. The depreciation 
rates and methods used as disclosed in note 9.6.1.4.
Yes No N/a
They are valued at cost. 
Investments Fixed asset investments in quoted shares, traded bonds and similar investments are
valued at initially at cost and subsequently at fair value (their market value) at the year Yes No N/a
end. The same treatment is applied to unlisted investments unless fair value cannot be

measured reliably in which case it is measured at cost less impairment.
Yes No N/a
Investments held for resale or pending their sale and cash and cash equivalents with a
maturity date of less than 1 year are treated as current asset investments 
Yes No N/a
Stocks and work in Stocks held for sale as part of non-charitable trade are measured at the lower or cost or net
progress realisable value. 
Yes No N/a
Goods or services provided as part of a charitable activity are measured at net realisable value
based on the service potential provided by items of stock. 
Yes No N/a
Work in progress is valued at cost less any foreseeable loss that is likely to occur on the
contract. 
Yes No N/a
Debtors (including trade debtors and loans receivable) are measured on initial recognition at
Debtors settlement amount after any trade discounts or amount advanced by the charity. Subsequently,

they are measured at the cash or other consideration expected to be received.
The charity has has investments which it holds for resale or pending their sale and cash and Yes No N/a
Current asset cash equivalents with a maturity date less than one year. These include cash on deposit and
investments cash equivalents with a maturity date of less than one year held for investment purposes rather 
than to meet short term cash commitments as they fall due.
Yes No N/a
They are valued at fair value except where they qualify as basic financial instruments.

POLICIES ADOPTED Not Applicable
ADDITIONAL TO OR
DIFFERENT FROM
THOSE ABOVE
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Section C Notes to the accounts (cont)

Note 3 Analysis of income

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Restricted
Unrestricted income Endowment
funds funds funds Total funds Prior year
Analysis £ £
Donations Donations and gifts 328,007 - - 328,007 317,810
and legacies: - - - - -
Total 328,007 - - 328,007 317,810
Charitable Sales of Christmas cards - - - - 3,430
activities: - - - - -
- - - - -
Total - - - - 3,430
TOTAL INCOME 328,007 - - 328,007 321,240
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Other information:

All income in the prior year was unrestricted except for: (please provide description and amounts)

All income in the current year and prior year was unrestricted. A donation of £283,388 (prior year: £247,737) was received and whilst not restricted, the donation was designated for funding the charity's commitment to fund the Oxford University Natural History Study.

Where any endowment fund is converted into income in the reporting period, please give the reason for the conversion.

Where any endowment fund is converted into income in the prior period, please give the reason for the conversion.

Not Applicable Not Applicable

Within the income items above the following items are material: (please disclose the nature, amount and any prior year amounts)

Material donations have been received in the current and prior year to fund the the Oxford University Natural History Study commitment.

Section C Notes to the accounts (cont)

Note 4 Analysis of expenditure

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This year Last year
Restricted
Unrestricted Restricted Endowment Unrestricted income Endowment
Analysis funds income funds funds Total funds funds funds funds Total funds
Expenditure on raising funds: £ £
Incurred seeking donations 562 - - 562 331 - - 331
Staging fundraising events
4,805 - - 4,805 2,133 2,133
Advertising, marketing, direct mail and
publicity 177 - - 177 333 - - 333
- - - - - - - -
Total expenditure on raising funds 5,544 - - 5,544 2,797 - - 2,797
Separate material item of expense
Commitment to Fund the Oxford University
Natural History Study - - - - - - - -
- - - - - - - -
- - - - - - - -
Total - - - - - - - -
TOTAL EXPENDITURE 5,544 - - 5,544 2,797 - - 2,797
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Section C Notes to the accounts

Note 5 Details of certain items of expenditure

Fees for examination of the accounts

Other fees (for example: financial advice, consultancy, accountancy services) paid
to the independent examiner
Independent examiner’s fees
Assurance services other than audit or independent examination
Tax advisory fees		 This year
Last year
£
£
- -
- -
- -
- -

Section C Notes to the accounts (cont)

Note 6 Grantmaking

This year:

6.1 Analysis of grants made

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Grants to
Analysis institutions Grants to individuals Support costs Total
£ £
Oxford University Natural History Study - - - -
Total - - - -
6.2 Grants made to institutions
https://cureangelman.org.uk/oxford-natural-
The charity has not made any additional grants in the current year. In the year ended 31
-
history study
December 2020 the charity made a commitment to fund the Oxford University's Natural
History Study of up to £1,077,103. In the current year payments were made under this
commitment of £293,610 (prior year: £287,931). At the end of the reporting period the
outstanding funding committment was £495,652 (prior year:£789,172) (see note 7 and note
8). Details of the institution supported, purpose of the grant and total paid to each institution
is available on the charity's web site.
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TOTAL GRANTS PAID
Total grants to institutions in reporting period
Oxford University
Purpose
Angelman Syndrome Natural History Study
Names of institution		 Total amount of
grants paid £
293,610
293,610
293,610

Last year:

6.3 Analysis of grants made

Last year:
6.3 Analysis of grants made
Analysis
Oxford University Natural History Study
Total		 Grants to
institutions
Grants to individuals
Support costs
Total
£
£
- - -
-
- - - -

6.4 Grants made to institutions

My charity has made grants to particular institutions that are material in the context of its grantmaking. Details of the institution supported, purpose of the grant and total paid to each institution is available on the charity's web site.

https://cureangelman.org.uk/oxford-natural- history study

TOTAL GRANTS PAID
Total grants paid to institutions in reporting period
Names of institution
Purpose
Oxford University
Angelman Syndrome Natural History Study		 Total amount of
grants paid £
287,931
287,931
287,931

Section C Notes to the accounts (cont)

Note 7 Creditors and accruals

7.1 Analysis of creditors

Accruals for grants payable

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Amounts falling due within Amounts falling due after
one year more than one year
This year Last year This year Last year
£ £ £ £
283,388 293,590 212,174 495,582
Total 283,388 293,590 212,174 495,582
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Section C Notes to the accounts (cont)

Note 8 Reconciliation of funding commitments

8.1 Movements in funding commitment during the period

8.2 Please provide:
- a brief description of any obligations on the
balance sheet and the expected amount and timing of
resulting payments;
- an indication of the uncertainties about the amount
or timing of those outflows; and
- the amount of any expected reimbursement, stating
the amount of any asset that has been recognised for
that expected reimbursement.
8.3 Where unrestricted funds have been designated
to a fund commitment, please disclose the nature of
any amounts designated and the likely timing of that
expenditure.
Amounts added in current period
Amounts paid in the current period
Balance at the start of the reporting period
Balance at the end of the reporting period


The charity's only funding commitment
relates to the Oxford University Natural
History Study. No formal designation of
untrestricted funds has been made but it
is expected that these amounts will be
paid out of unrestricted funds.
The only obligation of the charity relates
to the funding commitment made to
Oxford University for the Natural History
Study. Of the £1,077,103 committed
£495,562 remains due at the end of the
reporting period. The remaining amount
will be paid over the next 2 years, with
£283,388 payable in the next year.
Not Applicable, the payments are to be
made in accordance with the budget
agreed within the commitment
agreement.
No amounts are expected to be
reimbursed and no assets have been
recongnised in relation to any expected
reimbursments.
This year		 This year
Last year
£
£
789,172 1,077,103
-
-
- 293,610 - 287,931
495,562 789,172
The charity's only funding commitment
relates to the Oxford University Natural
History Study. No formal designation of
untrestricted funds has been made but it
is expected that these amounts will be
paid out of unrestricted funds.
The only obligation of the charity relates
to the funding commitment made to
Oxford University for the Natural History
Study. Of the £1,077,103 committed
£789,172 remains due at the end of the
reporting period. The remaining amount
will be paid over the next 3 years, with
£293,590 payable in the next year.
Not Applicable, the payments are to be
made in accordance with the budget
agreed within the commitment
agreement.
No amounts are expected to be
reimbursed and no assets have been
recongnised in relation to any expected
reimbursments.
Last year

Section C Notes to the accounts (cont)

Note 9 Cash at bank and in hand

Cash at bank and on hand Other Total

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This year Last year
£ £
430,360 401,507
- -
430,360 401,507
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Section C Notes to the accounts (cont)

Note 10 Events after the end of the reporting period

Please provide details of the nature of the
event
Provide an estimate of the financial effect
of the event or a statement that such an
estimate cannot be made
Payments of £283,388 were made in the
after the end of the reporting period but
before the accounts were approved.
This reduced the funding commitment
liability to £212,174.
Payments of £293,610 were made
in the after the end of the reporting
period but before the accounts were
approved. This reduced the funding
commitment liability to £495,582.
Further payments have been made
to fund the Oxford University Natural
History Study in line with the
commitment made.
This year
Last year
Further payments have been made to
fund the Oxford University Natural
History Study in line with the
commitment made.

Section C Notes to the accounts (cont)

Note 11 Transactions with trustees and related parties

11.1 Trustee remuneration and benefits

This year

None of the trustees have been paid any remuneration or received any other benefits from an employment with their charity or a related entity (True or False)

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TRUE
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Last year

None of the trustees have been paid any remuneration or received any other benefits from an employment with their charity or a related entity (True or False)

TRUE

11.2 Trustees' expenses

No trustee expenses have been incurred (True or False)

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TRUE
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11.3 Transaction(s) with related parties

Please give details of any transaction undertaken by (or on behalf of) the charity in which a related party has a material interest, including where funds have been held as agent for related parties. If there are no such transactions, please enter 'true' in the box provided.

This year

There have been no related party transactions in the reporting period (True or False)

TRUE

In relation to the transactions above, please provide the terms and conditions, including any security and the nature of any payment (consideration) to be provided in settlement. Not Applicable For any related party, please provide details of any guarantees given or received. Not Applicable

TRUE

Last year

There have been no related party transactions in the reporting period (True or False)

In relation to the transactions above, please provide the terms and conditions, including any security and the nature of any payment (consideration) to be provided in settlement. For any related party, please provide details of any guarantees given or received.

Not Applicable

One of the trustees together with another individual has agreed to make up any shortfall in funding if the chairty are unable to fund the amounts committed to the Oxford University Natural History Study.

Section B Disclosure Only ￿mplete if the examiner needs to highlight matters of concem (see CC32, Independent examination of charity accounts: directions and guidance for examiners). Glve here brlef detalls of any Items that the examiner wishes to dlsclose. IER October 2018

CHARITY COMMISSION FOR ENGLAND AND WALES Independent examiner's report on the accounts Seclion A Independent Examiner's Report Report to the trusteesl rnombors of Foundation Ange1rn￿ Syndrome Therapeutics UK On a¢counts for the year 31 December 2022 ended I Charity no (if any) 1167984 Set out on pages rs o 5hpE I report to the trustees on my examination of the accounts of the above charity {'the Trusf) for the year ended 31112 12022. Responslbllltles and As the charity trustees of the Trust, you are responsible for the p￿paration basls of report of the accounts in accordance with the requirements of the Chanties Act 2011 ("the Aci"). I report in reswct of my examination of the Trust's accounts carried ¢>Jt under section 145 of the 2011 Act and in carying out my examination, I have followed the applicable Directions given by the Charity Commission under Sec1¢￿ 145(5)(b) of the Ad. I have ¢￿pleted rny ex￿Ination. I Confi￿ that no material matters have corne to my attention {other than that disclosed below ') in connection with the examination which gives me cause to believe that in, any material resped.. accounting records were not kept in accordance wrth section 130 of the Ad or the accounts do rK)t accord wilh tr accounting records Independent examiner's statement I have no concems and have come across no other matters in connecti with the eXaMinat￿n to which attention should be drawn in order to enable a proper understandirvJ of the a¢¢ounts to be reached. . Plea delete the words in th8 brackets rf they do not apply. Slgned: Date: Name: 4T£icL Relevant wofesslonal qualfflcatlon(sl or body (rf any): dccA 2006SgS Address: IER October 2018