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2023-12-31-accounts

COMPANY REGISTRATION NUMBER: 09335387 CHARITY REGISTRATION NUMBER: 1162536

Breakthrough Foundation Company Limited by Guarantee

Financial Statements

For the year ended 31 December 2023

CRITCHLEYS AUDIT LLP

Chartered Accountants & statutory auditor Beaver House 23 - 38 Hythe Bridge Street Oxford OX1 2EP

Breakthrough Foundation

Company Limited by Guarantee

Financial Statements

Year ended 31 December 2023

Pages
Trustees' annual report (incorporating the directors' report) 1 to 8
Independent auditor's report to the members 9 to 13
Statement of financial activities (including income and
expenditure account) 14
Statement of financial position 15
Statement of cash flows 16
Notes to the financial statements 17 to 23

Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report)

Year ended 31 December 2023

The trustees, who are also the directors for the purposes of company law, present their report and the financial statements of the charity for the year ended 31 December 2023.

Reference and administrative details

Registered charity name Breakthrough Foundation Charity registration number 1162536 Company registration number 09335387 Principal office and registered 4 Hill Street office London W1J 5NE The trustees

Ms S Pavlova Mrs D A Forsdick R J Bonney C F J Chan J A Hutchinson Company secretary Mrs D A Forsdick Auditor Critchleys Audit LLP Chartered Accountants & statutory auditor Beaver House 23 - 38 Hythe Bridge Street Oxford OX1 2EP Bankers J P Morgan Chase Bank. N.A 390 Madison Ave, Floor 24 New York NY10017 United States of America Goldman Sachs & Co LLC 200 West Street New York NY 10282 United States of America Solicitors Goodwin Procter LLP 901 New York Avenue NW Washington DC 20001; and 100 Cheapside London EC2V 6DY

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Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report) (continued)

Year ended 31 December 2023

Structure, governance and management

The charity is a charitable company limited by guarantee. The charity is governed by its Memorandum and Articles of Association.

The charity is managed by its Board of trustees.

The major risks, as identified by the trustees, have been reviewed and systems established to mitigate those risks. The charity is dependent on the continued ability of its major donor to continue to support the charity.

The Trustees have been selected from their skills and professionalism and come with many years of experience in different walks of life. New trustees are appointed by the existing board of trustees for a term of 3 years (subject to re-election). New trustees are inducted into their role as trustees in a series of briefings on the work of the charity, where not already familiar with the work of the charity.

The Trustees, who are also the directors for the purpose of Company Law and who were directors during the year or were appointed prior to the date of signature of the financial statements are:

S Pavlova D A Forsdick R J Bonney C F J Chan J A Hutchinson

Objectives and activities

The main objects of the charity are for the public benefit, to advance knowledge and learning in research of useful subjects of study by:

(a) granting awards for undertaking research and disseminating the useful results to the public; and

(b) recognising the outstanding achievements in research to act as an incentive to others.

The Trustees confirm that they have complied with the duty in section 17(5) of the Charities Act 2011 to have due regard to the guidance published by the Charity Commission.

Grant-making policy

The Trustees are of the view that the majority of their grant making will lie in the provision of grants to the two US organizations, Breakthrough Prize Foundation and Breakthrough Prize in Life Sciences Foundation. (see https:/breakthroughprize.org).

The charity current policy is normally to only accept grant proposals which have been initiated by the Trustees.

Strategic report

The following sections for achievements and performance and financial review form the strategic report of the charity.

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Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report) (continued)

Year ended 31 December 2023

Achievements and performance

The following projects by the Breakthrough Prize Foundation and Breakthrough Prize in Life Sciences Foundation were made possible in 2023 with contributions provided by the Charity:

Humanitarian relief

In response to the global refugee crisis resulting from the war in Ukraine, the earthquakes in Turkey and Syria, and other causes, the Breakthrough Prize Foundation donated funds to several humanitarian programs in 2023.

Ukraine donations

In March 2023, the Breakthrough Prize Foundation announced a donation of $500,000 to a consortium of universities including Tel Aviv University, the Hebrew University of Jerusalem and the Technion, to fund a special program of emergency fellowships, enabling scientists forced to flee from Ukraine to maintain their livelihoods and continue their research.

To further support Ukrainian scientists, in August the Foundation provided $2.1 million to the National Academy of Sciences (NAS), in the form of a challenge grant to encourage additional philanthropic support and to help cover the costs of several Ukrainian-led research projects.

Tech for Refugees

Tech For Refugees was launched by the Breakthrough Prize Foundation in 2022. The initiative distributes funds to partner technology organizations to bring provisions, housing, transport, logistical services and other aid to refugees around the world.

In February 2023, the initiative built on its highly successful collaboration with Flexport.org, the outreach arm of the global logistics technology company, with a new $6 million grant to bring provisions and support to refugees from Ukraine, Pakistan, and the Horn of Africa, as well as people in crisis zones around the globe, including those affected by the earthquakes in Turkey and Syria.

Also in February 2023, the initiative made a multi-year commitment to support the humanitarian efforts of the International Rescue Committee (IRC), helping to drive the expansion of the IRC's Signpost platform, which provides information and support to refugees working to rebuild their lives in new countries. The three-year commitment targeted the rollout of Signpost in 10 locations in Africa, the Middle East, Asia Pacific and the Americas. Later that year, Tech For Refugees funded another of its technology partners, Uber, to provide the IRC with ride credits to address refugees' transport needs as they seek work, education, and economic opportunities.

In May 2023, Tech For Refugees launched another collaboration with Uber to help victims of the Turkey and Syria earthquakes. The initiative provided grants to data-matching platform NeedsMap, another of its partner organizations, enabling users in the region to buy Uber ride credits that cover all fees and support costs for all rides taken. The scheme focused on a region severely affected by the earthquake, including eleven cities.

In June 2023, the initiative partnered with UNICEF USA, the United Nations Children's Fund, to bring vital educational assistance to children affected by the war in Ukraine, providing a grant to support education programming for young people in humanitarian disaster areas around the world.

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Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report) (continued)

Year ended 31 December 2023

Science Prizes

Breakthrough Prizes

The Charity's 2023 grant-making activities distributed $15.75 million in prize-money awarded for scientific advances. Breakthrough Prizes in Life Sciences were given for the development of CAR T cells, a transformative cancer immunotherapy treatment, which have eliminated the disease in patients with certain blood cancers, including types of leukaemia; for the creation of the first effective treatment for the underlying cause of cystic fibrosis, greatly improving quality and length of life for people with this disease; and for the discovery of the most common genetic causes of Parkinson's Disease. In Fundamental Physics, the prize went to two pioneers of statistical physics, who have spent half a century studying quantum field theories with relevance to systems ranging from magnetism and superconducting materials to the information content of black holes. In Mathematics, the prize honoured major advances in differential geometry, a field that uses the tools of calculus to study curves, surfaces and spaces.

The following prizes were awarded:

Breakthrough Prizes in Life Sciences to: Carl H. June and Michel Sadelain; Sabine Hadida, Paul Negulescu, and Fredrick Van Goor; Thomas Gasser, Ellen Sidransky and Andrew Singleton.

Breakthrough Prize in Fundamental Physics: John Cardy and Alexander Zamolodchikov.

Breakthrough Prize in Mathematics: Simon Brendle.

Six $100,000 New Horizons Prizes were awarded for early-Career achievements in Physics and Mathematics.

Three $50,000 Maryam Mirzakhani New Frontiers Prizes were given to outstanding women mathematicians who had recently completed their PhDs.

Breakthrough Junior Challenge

The Breakthrough Junior Challenge is a global science video competition for high school students, designed to spread key concepts from science and mathematics among young people and increase their enthusiasm for STEM subjects. In 2023 the Foundation organized and ran the 9[th] annual Challenge. Entries were submitted by 2,400 students from over 100 countries, with their videos reaching more than 50 million people on Facebook and YouTube. The winner, 17-year-old Sia Godika from Bangalore, was recognized for her video about induced pluripotent stem cells, receiving a $250,000 university scholarship. A $50,000 prize was given to her science teacher, and $100,000 in funding pledged to build a state-of-the-art science lab at a school in her neighbourhood in Bangalore.

The Foundation's activities in the administration of the Challenge included processing its thousands of applications and video submissions; co-ordinating a peer-to-peer review process and running various rounds of evaluation and expert judging; running a Popular Vote to decide regional winners; and distributing the prizes. In addition, the Foundation ran publicity, media and communications campaigns, including producing videos about the Challenge and the eventual winner.

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Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report) (continued)

Year ended 31 December 2023

Scientific research

Breakthrough Initiatives projects

Breakthrough Listen is a global astronomical program searching for "technosignatures" - astronomical evidence of extraterrestrial intelligence. In January 2023 the Listen team published a paper in the journal Nature Astronomy describing a new artificial intelligence-driven method for searching astronomical data. Analysis of 480 hours of data from the Green Bank Telescope (GBT) in West Virginia produced eight previously undetected "signals of interest" - signals with characteristics expected of genuine technosignatures - from approximately 3 million signals identified in scans of 820 stars.

The Listen program also initiated the move of its headquarters from the University of California, Berkeley, to Oxford University in the U.K. The move will enable the team to better co-ordinate its activities with global partners including the Square Kilometre Array (SKA), a global effort to deliver a transformational radio telescope array by 2030, for which Listen is developing innovative hardware, software and theoretical contributions to radio astrophysics to leverage the SKA for the search for life on extrasolar planets.

Breakthrough Watch is an optical astronomy search for primitive cellular life on nearby exoplanets. In February 2023, the Foundation began funding Phase 2 of its TOLIMAN space telescope program, a mission to discover potentially habitable exoplanets in the Alpha Centauri system, the closet star system to our own. The TOLIMAN mission is an ongoing collaboration with the University of Sydney and other partners to design, build and launch a space telescope that can search for exoplanets in the around nearby stars. Phase 2 includes the design, build and integration of the spacecraft with the telescope, in partnership with the University of Sydney and Bulgarian aerospace manufacturer EnduroSat.

Breakthrough Starshot is an aerospace engineering program to develop gram-scale robotic space probes that could fly interstellar missions on the timescale of a human generation. Phase 1 of the program, investigating its scientific, engineering and technological feasibility, was launched in 2016. 2023 saw the culmination of this phase, in which the Starshot team conducted a large-scale analysis of the results of the previous 7 years of proposals, investigations and experiments, including design and structure of the proposed craft, the laser-driven launch system, the challenges of interstellar communications, and the analysis of the entire Starshot concept, from launch to final signal reception, as a unified aerospace system.

Breakthrough Discuss is an annual academic conference sponsored and run by the Breakthrough Initiatives, focusing on the questions of life and civilizations in the universe and next-generation possibilities for space travel. The 2023 conference was held in June at UC Santa Cruz as well as online. It was co-hosted by the African Astronomical Society, Caltech, NASA's Ames Research Center, the SETI Institute, the University of Arizona, UC Santa Cruz, UC Berkeley, the University of Manchester and the University of Oxford Department of Physics. The event brought together leaders in astronomy, space science, engineering and other fields to debate how near-Earth locations can advance the search for extraterrestrial intelligence; new ways to look for potentially habitable exoplanets in our cosmic back yard; and how human technology could reach nearby stars.

Medical Research

The Charity signed a 3-year grant of $14,994,111 with Friends of Tel Aviv Medical Center in Israel, funding the establishment of a new AI Global Center of Excellence. The project aims to integrate Artificial Intelligence (AI) into healthcare systems, and help make the benefits of medical AI technologies accessible to patients and healthcare providers worldwide. Programs that the Center of Excellence will develop include prediction of patients’ pathologies and service use, new medical appliances, and tools for data management, learning and operational planning.

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Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report) (continued)

Year ended 31 December 2023

Science communication

As part of the Foundation's mission to popularize the biggest ideas in science, in 2023 it began a threeyear commitment to support the Big Picture Science podcast. The podcast, hosted by the astronomer and author Seth Shostak and science journalist Molly Bentley, focuses on connections between the latest science and technology research to produce an overview of the current state-of-the-art, with a particular interest in the question of extraterrestrial life and intelligence.

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Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report) (continued)

Year ended 31 December 2023

Financial review

The results of the charity in the year are set out in the Statement of Financial Activities on page 14.

As at 31 December 2023 free reserves (represented by unrestricted funds) were $3,572,605, surplus.

The charity does not raise money from the public and is dependent on grants from a major donor.

Due to the funding arrangements the Trustees consider there is no requirement for the charity to hold reserves.

Plans for future periods

The charity's future plans are to continue to provide grants the two US Foundations: Breakthrough Prize Foundation and Breakthrough Prize in Life Sciences Foundation.

Trustees' responsibilities statement

The trustees, who are also directors for the purposes of company law, are responsible for preparing the trustees' report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

Company law requires the charity trustees to prepare financial statements for each year which give a true and fair view of the state of affairs of the charitable company and the incoming resources and application of resources, including the income and expenditure, for that period.

In preparing these financial statements, the trustees are required to:

The trustees are responsible for keeping adequate accounting records that are sufficient to show and explain the charity's transactions and disclose with reasonable accuracy at any time the financial position of the charity and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

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Breakthrough Foundation

Company Limited by Guarantee

Trustees' Annual Report (Incorporating the Directors' Report) (continued)

Year ended 31 December 2023

Auditor

Each of the persons who is a trustee at the date of approval of this report confirms that:

The auditor is deemed to have been re-appointed in accordance with section 487 of the Companies Act 2006.

The trustees' annual report (incorporating the directors' report) and the strategic report were approved on 23 September 2024 and signed on behalf of the board of trustees by:

C F J Chan Trustee

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Breakthrough Foundation

Company Limited by Guarantee

Independent Auditor's Report to the Members of Breakthrough Foundation

Year ended 31 December 2023

Opinion

We have audited the financial statements of Breakthrough Foundation (the 'charity') for the year ended 31 December 2023 which comprise the statement of financial activities (including income and expenditure account), statement of financial position, statement of cash flows and the related notes, including a summary of significant accounting policies. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including FRS 102 The Financial Reporting Standard applicable in the UK and Republic of Ireland (United Kingdom Generally Accepted Accounting Practice).

In our opinion the financial statements:

Basis for opinion

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the auditor's responsibilities for the audit of the financial statements section of our report. We are independent of the charity in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the FRC’s Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Conclusions relating to going concern

In auditing the financial statements, we have concluded that the trustees' use of the going concern basis of accounting in the preparation of the financial statements is appropriate.

Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the charity's ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.

Our responsibilities and the responsibilities of the trustees with respect to going concern are described in the relevant sections of this report.

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Breakthrough Foundation

Company Limited by Guarantee

Independent Auditor's Report to the Members of Breakthrough Foundation (continued)

Year ended 31 December 2023

Other information

The other information comprises the information included in the annual report, other than the financial statements and our auditor’s report thereon. The trustees are responsible for the other information. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon.

In connection with our audit of the financial statements, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether there is a material misstatement in the financial statements or a material misstatement of the other information. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We have nothing to report in this regard.

Opinions on other matters prescribed by the Companies Act 2006

In our opinion, based on the work undertaken in the course of the audit:

Matters on which we are required to report by exception

In the light of the knowledge and understanding of the charity and its environment obtained in the course of the audit, we have not identified material misstatements in the trustees' report.

We have nothing to report in respect of the following matters in relation to which the Companies Act 2006 requires us to report to you if, in our opinion:

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Breakthrough Foundation

Company Limited by Guarantee

Independent Auditor's Report to the Members of Breakthrough Foundation (continued)

Year ended 31 December 2023

Responsibilities of trustees

As explained more fully in the trustees' responsibilities statement, the trustees (who are also the directors for the purposes of company law) are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as the trustees determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, the trustees are responsible for assessing the charity's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the trustees either intend to liquidate the charity or to cease operations, or have no realistic alternative but to do so.

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Breakthrough Foundation

Company Limited by Guarantee

Independent Auditor's Report to the Members of Breakthrough Foundation (continued)

Year ended 31 December 2023

Auditor's responsibilities for the audit of the financial statements

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor's report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in in in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.

The extent to which our procedures are capable of detecting irregularities, including fraud, is detailed below.

We assessed the susceptibility of the charity's financial statements to material misstatement, including obtaining an understanding of how fraud might occur, by:

To address the risk of fraud through management bias and override of controls, we:

In response to the risk of irregularities and non-compliance with laws and regulations, we designed procedures which included, but were not limited to:

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Breakthrough Foundation

Company Limited by Guarantee

Independent Auditor's Report to the Members of Breakthrough Foundation (continued)

Year ended 31 December 2023

There are inherent limitations in our audit procedures described above. The more removed that laws and regulations are from financial transactions, the less likely it is that we would become aware of noncompliance. Auditing standards also limit the audit procedures required to identify non-compliance with laws and regulations to enquiry of the directors and other management and the inspection of regulatory and legal correspondence, if any.

Material misstatements that arise due to fraud can be harder to detect than those that arise from error as they may involve deliberate concealment or collusion.

A further description of our responsibilities is available on the Financial Reporting Council's website at: https:/www.frc.org.uk/auditorsresponsibilities. This description forms part of our auditor's report.

Use of our report

This report is made solely to the charity's members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the charity's members those matters we are required to state to them in an auditor's report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the charity and the charity's members as a body, for our audit work, for this report, or for the opinions we have formed.

Robert Kirtland (Senior Statutory Auditor)

Beaver House 23 - 38 Hythe Bridge Street Oxford OX1 2EP

For and on behalf of Critchleys Audit LLP Chartered Accountants & statutory auditor

26 September 2024

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Breakthrough Foundation

Company Limited by Guarantee

Statement of Financial Activities (including income and expenditure account)

Year ended 31 December 2023

2023 2023 2022
Unrestricted
funds Total funds Total funds
Note $ $ $
Income and endowments
Donations and legacies 5 108,678,317 108,678,317 62,539,865
Investment income 6
58,973
58,973 25,871
--------------------------------------------------- --------------------------------------------------- ----------------------------------------------
Total income 108,737,290 108,737,290 62,565,736
=================================================== =================================================== ==============================================
Expenditure
Expenditure on raising funds:
Costs of raising donations and legacies 7
40,614
Expenditure on charitable activities 8,9 114,389,610 114,389,610 55,695,097
--------------------------------------------------- --------------------------------------------------- ----------------------------------------------
Total expenditure 114,389,610 114,389,610 55,735,711
=================================================== =================================================== ==============================================
(Recovery)/Losses on impairment (note 15) (1,181,107) (1,181,107) 3,341,053
--------------------------------------------------- --------------------------------------------------- ----------------------------------------------
Net (expenditure)/income and net movement in funds (4,471,213) (4,471,213) 3,488,972
=================================================== =================================================== ==============================================
Reconciliation of funds
Total funds brought forward 8,043,818 8,043,818 4,554,846
--------------------------------------------------- --------------------------------------------------- ----------------------------------------------
Total funds carried forward 3,572,605 3,572,605 8,043,818
=================================================== =================================================== ==============================================

The statement of financial activities includes all gains and losses recognised in the year. All income and expenditure derive from continuing activities. In 2022, all funds were unrestricted.

The notes on pages 17 to 23 form part of these financial statements.

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Breakthrough Foundation

Company Limited by Guarantee

Statement of Financial Position

31 December 2023

2023 2022
Note $ $ $
Fixed assets
Investments 15 2,786,106 2,036,362
Current assets
Debtors 16 12,958,138 3,112,900
Cash at bank and in hand 4,432,178 9,894,556
---------------------------------------------- ----------------------------------------------
17,390,316 13,007,456
Creditors: amounts falling due within one year 17 8,616,188 3,500,000
---------------------------------------------- ----------------------------------------------
Net current assets/(liabilities) 8,774,128 9,507,456
---------------------------------------------- ----------------------------------------------
Total assets less current liabilities 11,560,234 11,543,818
Creditors: amounts falling due after more than
one year 18 7,987,629 3,500,000
---------------------------------------------- ----------------------------------------------
Net assets 3,572,605 8,043,818
============================================== ==============================================
Funds of the charity
Unrestricted funds 3,572,605 8,043,818
----------------------------------------- -----------------------------------------
Total charity funds 19 3,572,605
=========================================
8,043,818
=========================================

These financial statements have been prepared in accordance with the provisions applicable to companies subject to the medium companies regime.

These financial statements were approved by the board of trustees and authorised for issue on 23 September 2024, and are signed on behalf of the board by:

C F C Chan Trustee

Company registration number: 09335387 (England and Wales)

The notes on pages 17 to 23 form part of these financial statements.

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Breakthrough Foundation

Company Limited by Guarantee

Statement of Cash Flows

Year ended 31 December 2023

2023 2022
$ $
Cash flows from operating activities
Net (expenditure)/income (4,471,213) 3,488,972
Adjustments for:
(Recovery)/Losses on impairment (note 15) (1,181,107) 3,341,053
Bank interest received (58,973) (25,871)
Accrued expenses/(income) 9,603,817 (12,067,000)
Changes in:
Trade and other debtors (9,845,238) 8,555,866
----------------------------------------- ----------------------------------------------
Cash generated from operations (5,952,714) 3,293,020
Interest received 3,809 25,871
----------------------------------------- -----------------------------------------
Net cash (used in)/from operating activities (5,948,905) 3,318,891
========================================= =========================================
Cash flows from investing activities
Dividends, interest and rents from investments 55,164
Proceeds from sale of other investments 431,363 4,424,245
----------------------------------------- -----------------------------------------
Net cash from investing activities 486,527 4,424,245
========================================= =========================================
Net (decrease)/increase in cash and cash equivalents (5,462,378) 7,743,136
Cash and cash equivalents at beginning of year 9,894,556 2,151,420
----------------------------------------- -----------------------------------------
Cash and cash equivalents at end of year 4,432,178 9,894,556
========================================= =========================================

The notes on pages 17 to 23 form part of these financial statements.

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Breakthrough Foundation

Company Limited by Guarantee

Notes to the Financial Statements

Year ended 31 December 2023

1. General information

The charity is a public benefit entity and a private company limited by guarantee, registered in England and Wales and a registered charity in England and Wales. The address of the registered office is 4 Hill Street, London, W1J 5NE.

2. Statement of compliance

These financial statements have been prepared in compliance with FRS 102, 'The Financial Reporting Standard applicable in the UK and the Republic of Ireland', the Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (Charities SORP (FRS 102)) and the Companies Act 2006.

3. Accounting policies

Basis of preparation

The financial statements are prepared in US dollars, which is the functional currency of the entity. All amounts presented in the financial statements are rounded to the nearest dollar.

Going concern

There are no material uncertainties about the charity's ability to continue.

Judgements and key sources of estimation uncertainty

The preparation of the financial statements requires management to make judgements, estimates and assumptions that affect the amounts reported. These estimates and judgements are continually reviewed and are based on experience and other factors, including expectations of future events that are believed to be reasonable under the circumstances.

Foreign currencies

Foreign currency transactions are initially recorded in the functional currency, by applying the spot exchange rate as at the date of the transaction. Monetary assets and liabilities denominated in foreign currencies are translated at the exchange rate ruling at the reporting date, with any gains or losses being taken to the statement of financial activities.

Fund accounting

Unrestricted funds are available for use at the discretion of the trustees to further any of the charity's purposes.

Designated funds are unrestricted funds earmarked by the trustees for particular future project or commitment.

Restricted funds are subjected to restrictions on their expenditure declared by the donor or through the terms of an appeal, and fall into one of two sub-classes: restricted income funds or endowment funds.

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Breakthrough Foundation

Company Limited by Guarantee

Notes to the Financial Statements (continued)

Year ended 31 December 2023

3. Accounting policies (continued)

Incoming resources

All income is included in the statement of financial activities when entitlement has passed to the charity, it is probable that the economic benefits associated with the transaction will flow to the charity and the amount can be reliably measured. The following specific policies are applied to particular categories of income:

Resources expended

Expenditure is recognised on an accruals basis as a liability is incurred. Expenditure includes any VAT which cannot be fully recovered, and is classified under headings of the statement of financial activities to which it relates:

All costs are allocated to expenditure categories reflecting the use of the resource. Direct costs attributable to a single activity are allocated directly to that activity. Shared costs are apportioned between the activities they contribute to on a reasonable, justifiable and consistent basis.

Investments

Unlisted equity investments are initially recorded at cost, and subsequently measured at fair value. If fair value cannot be reliably measured, assets are measured at cost less impairment.

Listed investments are measured at fair value with changes in fair value being recognised in income or expenditure.

Impairment of fixed assets

A review for indicators of impairment is carried out at each reporting date, with the recoverable amount being estimated where such indicators exist. Where the carrying value exceeds the recoverable amount, the asset is impaired accordingly. Prior impairments are also reviewed for possible reversal at each reporting date.

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Breakthrough Foundation

Company Limited by Guarantee

Notes to the Financial Statements (continued)

Year ended 31 December 2023

3. Accounting policies (continued)

Financial instruments

A financial asset or a financial liability is recognised only when the entity becomes a party to the contractual provisions of the instrument.

Basic financial instruments are initially recognised at the amount receivable or payable including any related transaction costs, unless the arrangement constitutes a financing transaction, where it is recognised at the present value of the future payments discounted at a market rate of interest for a similar debt instrument.

Current assets and current liabilities are subsequently measured at the cash or other consideration expected to be paid or received and not discounted.

4. Limited by guarantee

The company is limited by guarantee. Every member of the charity undertakes to contribute such amount as may be required (not exceeding £1) to the charity's assets if it should be wound up while he or she is a member or within one year after he or she ceases to be a member, for payment of the charity's debts and liabilities contracted before he or she ceases to be a member, and of the costs, charges and expenses of winding up, and for the adjustment of the rights of the contributories among themselves.

5. Donations and legacies

Unrestricted Total Funds Unrestricted Total Funds
Funds 2023 Funds 2022
$ $ $ $
Donations
Donations 108,678,317 108,678,317 62,539,865 62,539,865
=================================================== =================================================== ============================================== ==============================================

6. Investment income

Unrestricted Total Funds Unrestricted Total Funds
Funds 2023 Funds 2022
$ $ $ $
Bank interest received 58,973 58,973 25,871 25,871
---------------------------- ---------------------------- ---------------------------- ----------------------------
58,973
============================
58,973
============================
25,871
============================
25,871
============================

7. Costs of raising donations and legacies

Unrestricted Total Funds Unrestricted Total Funds
Funds 2023 Funds 2022
$ $ $ $
Costs of raising donations and
legacies - Investment management
costs 40,614 40,614
============== ============== ============================ ============================

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Breakthrough Foundation

Company Limited by Guarantee

Notes to the Financial Statements (continued)

Year ended 31 December 2023

8. Expenditure on charitable activities by fund type

Unrestricted Total Funds Unrestricted Total Funds
Funds 2023 Funds 2022
$ $ $ $
Donations 114,321,111 114,321,111 55,591,000 55,591,000
Bank charges 246 246 3,934 3,934
Support costs 68,253 68,253 100,163 100,163
--------------------------------------------------- --------------------------------------------------- ---------------------------------------------- ----------------------------------------------
114,389,610
===================================================
114,389,610
===================================================
55,695,097
==============================================
55,695,097
==============================================

9. Expenditure on charitable activities by activity type

Activities
undertaken
Grant funding
Support Total funds Total fund
directly
of activities
costs 2023 2022
$ $ $ $ $
Donations 114,321,111 114,321,111 55,591,000
Bank charges 246
246 3,934
Governance costs
68,253 68,253 100,163
-------------- --------------------------------------------------- ---------------------------- --------------------------------------------------- ----------------------------------------------
246 114,321,111 68,253 114,389,610 55,695,097
============== =================================================== ============================ =================================================== ==============================================
Analysis of grants
2023 2022
$ $
Grants to institutions
Breakthrough Prize Foundation 85,777,000 42,186,000
Breakthrough Prize in Life Sciences Foundation 555,000
The San Francisco Foundation 5,000,000
Trustees of the University of Pennsylvania 1,000,000 1,000,000
Conference of Europe Rabbis Stiftung 3,000,000
Friends of Tel Aviv Sourasky Medical Centre 17,519,111 2,250,000
Jewish Agency for Israel 5,000,000
GoFundMe.org 2,000,000
Previous grant commitments no longer due (1,000,000) (500,000)
Foundation CERN & Societe 2,500,000
American Friends of Magen David 3,525,000
Other 100,000
--------------------------------------------------- ----------------------------------------------
114,321,111 55,591,000
--------------------------------------------------- ----------------------------------------------
Total grants 114,321,111 55,591,000
=================================================== ==============================================
Net (expenditure)/income
Net (expenditure)/income is stated after charging/(crediting):
2023 2022
$ $
Foreign exchange differences 1,060
=======================
5,083
=======================

10. Analysis of grants

11. Net (expenditure)/income

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Breakthrough Foundation

Company Limited by Guarantee

Notes to the Financial Statements (continued)

Year ended 31 December 2023

12. Auditors remuneration

2023 2022
$ $
Fees payable for the audit of the financial statements 14,846 14,846
============================ ============================

13. Staff costs

The average head count of employees during the year was Nil (2022: Nil).

No employee received employee benefits of more than £60,000 during the year (2022: Nil).

14. Trustee remuneration and expenses

No remuneration or other benefits from employment with the charity or a related entity were received by the trustees; As at 31 December 2023, no travel costs (2022: Nil) were incurred by trustees.

15. Investments

Other
investments
$
Cost
At 1 January 2023 4,368,880
Additions
Disposals (4,190,778)
-----------------------------------------
At 31 December 2023 178,102
=========================================
Unrealised gain/(impairment)
At 1 January 2023 (2,332,518)
Disposals 3,759,415
Recovery of impairment losses 1,181,107
-----------------------------------------
At 31 December 2023 2,608,004
=========================================
Carrying amount
At 31 December 2023 2,786,106
=========================================
At 31 December 2022 2,036,362
=========================================

All investments shown above are held at valuation.

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Breakthrough Foundation

Company Limited by Guarantee

Notes to the Financial Statements (continued)

Year ended 31 December 2023

15. Investments (continued)

All investments shown above are held at fair value.

The investment remained as convertible investment securities as of 31 December 2021. In May 2022, following the sale of assets by the issuer of the convertible investment securities, the charity exchanged the convertible investment securities for an initial cash distribution of $1,460,707, and 65,281 shares in the acquiring group.

In January 2023, the charity sold its remaining shares in the acquiring group for $431,363. In March 2024, the liquidator of the issuer of the convertible investment securities notified the charity that the final distribution to the initial holders of the convertible investment securities would be effected in April 2024. After a deduction of withholding tax of $912,801, the charity received $1,873,305 from the final distribution.

On 18 May 2021 a donation was made of an interest in Maxwell Investment Holdings, L.P, a limited liability partnership. The interest currently has no economic value.

16. Debtors

2023 2022
$ $
Prepayments and accrued income 12,958,138
==============================================
3,112,900
=========================================

----- Start of picture text -----
|| |---| |There is $5,487,628 debtors falling due after more than one year.|

----- End of picture text -----

17. Creditors: amounts falling due within one year

2023 2022
$ $
Accrual for grants payable 8,616,188 3,500,000
========================================= =========================================
18. Creditors: amounts falling due after more than one year
2023 2022
$ $
Accrual for grants payable 7,987,629
=========================================
3,500,000
=========================================

19. Analysis of charitable funds

Unrestricted funds

At At
1 January Gains and 31 December
2023 Income Expenditure
losses
2023
$ $ $ $ $
General funds 8,043,818 108,737,290 (114,389,610) 1,181,107 3,572,605
========================================= ==================================================== ============================================================== ========================================= ================================================
At At
1 January Gains and 31 December
2022 Income Expenditure losses 2022
$ $ $ $ $
General funds 4,554,846
62,565,736
(55,735,711) (3,341,053)
8,043,818
========================================= =================================================== =================================================== =============================================== ============================================

- 22 -

Breakthrough Foundation

Company Limited by Guarantee

Notes to the Financial Statements (continued)

Year ended 31 December 2023

20. Analysis of changes in net debt

At At
1 Jan 2023 Cash flows 31 Dec 2023
$ $ $
Cash at bank and in hand 9,894,556
=========================================
(5,462,378)
=========================================

4,432,178
=========================================

21. Related parties

There were no related party transactions in the year.

- 23 -