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2022-12-31-accounts

ANTIBIOTICS RESEARCH UK - DEVELOPING NEW ANTIBIOTICS

UNAUDITED ACCOUNTS

FOR THE YEAR ENDED

31 DECEMBER 2022

Charity number: 1157884

ANTIBIOTICS RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

I N D E X P A G E
_______________
REFERENCE AND ADMINSTRATIVE INFORMATION 1
REPORT OF THE BOARD OF TRUSTEES 3
INDEPENDENT EXAMINER’S REPORT 12
STATEMENT OF FINANCIAL ACTIVITIES 13
BALANCE SHEETS 15
NOTES TO THE ACCOUNTS 16

ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REFERENCE AND ADMINISTRATIVE INFORMATION

Charity Name Antibiotic Research UK – Developing New Antibiotics Charity Number 1157884 Principal address Genesis 5 Church Lane Heslington York YO10 5DQ

TRUSTEES

The trustees of the charity are:

Mr S Dukes * Chair Mr N Stalbow (Resigned 16 February 2023) Mr J A Farmer Treasurer (resigned 11 April 2022) Professor C Bond Professor C Dowson Ms E Lyon* (Resigned 14 February 2023) Ms Cathy Tralau-Stewart (Appointed 20 October 2022) Mr Phil Robinson * Chair, Finance Committee (Appointed 20 October 2022) Ms Carla Brown (Appointed 20 October 2022, resigned 17 May 2023) Ms Fiona Russell * (Appointed 20 October 2022) Ms Rosemary Howell (Appointed 20 October 2022)

*Also, member/observer of the Finance Committee

Science Committee Professor Chris Dowson Interim Chair Dr Mike Allen Dr Lloyd Czaplewski Dr Tina Joshi Professor Mark Moloney (Resigned/end of term of tenure 6 September 2022) Professor David Roper (Resigned/end of term of tenure 6 September 2022) Professor Chris Schofield Dr Joe Standing Dr Mark Sutton Dr David Wareham Dr Alan Houston (Resigned 18 October 2022) Arlene Brailey (Appointed 8 February 2022, resigned 31 January 2023) Dr Chris Longshaw

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REFERENCE AND ADMINISTRATIVE INFORMATION (Continued)

Public Education and Patient Support Committee

Professor Christine Bond Chair
James Amos
Carolyn Childs
Professor Angharad Davies (Appointed 26 May 2022)
Dr Ryan Hamilton
Rebecca Harmston
Dr Roger Harrison
Dr Charles Mitchell
Dr Alison Staples
Dr Wendy Thompson (Resigned 16 November 2022)
Dr Neil Todd
Dr Oliver Van Hecke
Founding chairman Mr A Burgess
Chief Executive Professor R C Garner (Until 31 July 2022)
Jonathan Pearce (Appointed 1 August 2022)
Patron The Most Revd & Rt Hon the Lord Archbishop of York, S Cottrell
ADVISORS
Principal Bankers Lloyds Bank PLC
2 Pavement
York
YO1 9UP
Independent Examiner Mr N Clemit ACA, FCCA
JWPCreers LLP
Chartered Accountants
Genesis 5
Church Lane
Heslington
York
YO10 5DQ

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

The trustees present their report and the financial statements of the charity for the year ended 31 December 2022. The trustees have adopted the provisions of the Statement of Recommended Practice (SORP) “Accounting and Reporting by Charities” in preparing the annual report and financial statements of the charity.

The financial statements have been prepared in accordance with the accounting policies set out in notes to the accounts and comply with the charity’s governing document, the Charities Act 2011 and Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland published in October 2019.

WHO WE ARE AND WHAT WE DO

Antibiotic Research UK is a national organisation founded in 2014 which raises funds to support antibiotic research, provide information and support to patients and families affected by antimicrobial resistance, raise awareness about its work among the public and professionals, and influence and campaign for better national and international approaches to tackle antimicrobial resistance.

Antibiotic resistance, that is when infectious bacteria become resistant to antibiotic treatment, is on the rise globally. An article published in The Lancet in 2022 estimated that, in 2019, 1.27 million people died globally directly from an antibiotic resistant infection (Murray CJ, Ikuta KS, Sharara F, Swetschinski L, Aguilar GR, Gray A, et al, Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis, The Lancet, 2022; 399 (10325):629-5), a figure higher than people dying from HIV or malaria. This figure is alarming and whilst the highest number of deaths were in lower and middle income countries, COVID has shown us how quickly an infectious agent can spread around the globe.

Vision

A world free from deaths caused by drug-resistant infections.

Mission

To tackle the global threat of drug-resistant infections by:

Purpose

Values

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

STRUCTURE, GOVERNANCE AND MANAGEMENT

Constitution and trustee recruitment and appointment

Antibiotic Research UK was registered as a charitable incorporated organisation (CIO), with members, on 16 July 2014 and is governed by its constitution, which can be found on the Charity Commission website. Antibiotic Research UK has a wholly owned trading subsidiary, ANTRUK Enterprises Ltd, which is registered at Companies House (company registration no 10396024).

The work, management, finances and strategy of the charity are overseen by a board of trustees. The trustees who held office during the financial year and at the date of the report are set out on page 1.

The constitution requires there to be a minimum of three trustees and a maximum of twelve trustees in office at any one time. Trustees retire from office after a full term of three years, at the following annual general meeting. A trustee can seek re-election for a further term of office but not a third term without an interval of a year. Trustees can only be formally appointed as a trustee at an annual general meeting although a person can attend meetings as an observer prior to this point.

Purpose

The charity’s purposes are set out in its constitution, as follows:

“… to protect and promote the health of the public, in particular by sponsoring research into the diagnosis, treatment and cure of antibiotic-resistant bacterial infectious diseases, ensuring responsible and sustainable development and deployment of the findings of such research, and raising awareness through public-facing activities and the promotion of networks to share experience of such matters.”

Public benefit

The organisation’s work delivers public benefit by funding and developing research to address the issue of antibiotic and antimicrobial resistance, which already claim thousands of lives each year nationally and internationally. The number of deaths will continue to increase, unless new antibiotics are discovered and brought to market, and that the use of new and existing antibiotics is better managed and stewarded so as to prolong their use and increase their efficacy.

The organisation also provides invaluable support and assistance to those directly affected by antimicrobial resistance, as well as to the healthcare practitioners working with them. Reliable, evidence-based information and peer support helps them navigate their conditions and improve their longer term outcomes.

As part of our business planning processes, we review our aims and objectives each year, which includes looking at what we have achieved previously, and how our activities have benefited those groups of people we are set up to help. We have referred to the Charity Commission’s guidance on public benefit when reviewing our aims and objectives, and in planning our work for the future.

Board and management operations and structure

Board of trustees

The board of trustees meets at least four times a year to review the organisation’s work, finances and services, and to agree the strategic goals for the charity. The chief executive officer attends all meetings. The board is also establishing a process to review its own operation, effectiveness and governance.

A finance committee, chaired by the treasurer and comprising at least two other trustees, meets quarterly to monitor and scrutinise the charity’s financial strategy and operations, and makes recommendations to the full board of trustees.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

Board and management operations and structure (continued)

The board also operates two other committees, as follows:

Science Committee

The Science Committee is responsible for commissioning and monitoring the charity’s scientific research programmes. The Science Committee consists of a number of experienced antimicrobial scientists and clinicians, chaired by Chris Dowson. Full membership details can be found on page 1.

Public Engagement and Patient Support Committee

The Public Engagement and Patient Support Committee (PEPS) is focused on increasing awareness about the importance of tackling drug-resistance amongst professionals and the public. The Committee consists of a range of individuals including clinicians, AMR scientists, public health experts, education professionals and individuals to provide a patient perspective. The committee is chaired by Christine Bond and full membership details can be found on page 2.

Recruitment and appointment of new trustees

An annual review of the recruitment needs of the board of trustees is carried out under the leadership of the chair, including an audit of the current knowledge, experience, skills and abilities, and how they will be affected by any trustee departures in the future. Any trustee vacancies are advertised nationally, and via relevant professional and organisational networks, including the charity’s own supporter base, depending upon the expertise and specialisms required. Applicants are shortlisted against the criteria in the person specification for the role of trustee, including any specific qualities highlighted during the above audit. Shortlisted applicants are invited for interview by at least two trustees, one of whom will be the chair. Shortlisted applicants are only appointed where they have the necessary skills and qualities to contribute effectively to the charity’s governance and development.

All new trustees receive thorough induction and training, which includes information about the organisation’s constitution, accounts, financial reports and minutes of previous trustees’ meetings.

Management and organisation

Day-to-day operation of the charity, and strategy implementation, is delegated to the chief executive officer, who is supported by a small team of staff, working in the fields of grant and charity administration, patient support, media, press and PR management, fundraising and financial management.

Risk assessment and management

The organisation has adopted a risk management policy which lists the potential risks to the charity, with an indication of the level of risk.

The main areas of identified risk are in relation to:

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

Risk assessment and management (continued)

To address these risks, effective management measures and controls have been put in place by the trustees, including:

ACHIEVEMENTS AND PERFORMANCE

Although the impact of the Covid pandemic began to lift in 2022, challenges remained across the sector and country’s health services as the recovery began. Early in the year we were pleased to be part of the launch of the Infection Management Coalition’s White Paper, which set out a broad policy analysis and set of recommendations for the UK on how to tackle infection prevention and control, antibiotic stewardship and the rise of antimicrobial resistance. The Coalition brought together the health/pharmaceutical industry, professional bodies and the third sector with a shared and holistic vision built on the four pillars of: (a) outbreak and pandemic preparedness; (b) infection prevention; (c) rapid recognition, diagnosis and treatment of time-critical viral and bacterial infections; and (d) antimicrobial stewardship. The analysis and recommendations in the White Paper provided the backbone of external and public affairs work during 2022 and into 2023, including Antibiotic Research UK’s policy responses and media work on a range of issues, including the role of community pharmacies in antimicrobial stewardship, the then Health Secretary, Thérèse Coffey’s misplaced comments on antibiotic usage, and the strep A outbreak towards the end of the year. During the year the Coalition met with members of parliament and engagement work has continued into 2023, including roundtable meetings and representation at external events.

Our research programme continued its work, with the small research grants from 2021 being supplemented with a new project award for the PHASEDIN antimicrobial stewardship trial, based at Southampton University, which will focus on trialling an online toolkit for pharmacists as an intervention to improve antibiotic prescribing for a range of common infections.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

Patient Support

Throughout 2022, our Patient Support Service remained focused on supporting individuals (and their families) in resolving unanswered questions about infection and antibiotic resistance. The number of new enquiries dropped dramatically in 2022 to 272 (compared to 908 in 2021), a direct consequence of the ending of the pandemic, which had previously accounted for a high increase in the number of vaccine-related enquiries. Despite this, the service continued to provide vital support to those affected by resistant infections and we were able to start testing online support groups alongside our traditional phone and email enquiry services, while also updating and expanding the range of healthcare information we have available online or for use in healthcare settings. Our popular ASK Antibiotic Research UK service continued to answer online or via social media frequently asked questions about infections and their management, receiving 212,000 views in 2022, compared to 123,000 in the previous year, thus representing an overall growth of the support we provided compared to pre-pandemic years.

We also succeeded with our patient support outreach, engagement and advocacy work during 2022, working with both NICE and the Scottish Health Technology Group on health technology appraisals and a bacteriophage review, respectively. We also developed a constructive partnership with Well Pharmacy during the year, where we were pleased to provide continuing professional development training to the chain’s community pharmacy staff. Furthermore, we made inroads into collaborations with the NHS, including joining the NHS Midlands Regional Medicines Optimisation Group, establishing plans to carry out a pilot programme for distributing information to patients with resistant infections, and agreeing to work with the NHS Black Country Integrated Care Boards on its antimicrobial stewardship initiatives. We were also pleased to attend and present at a number of national events, including the major GP Guidelines Live conference, in order to raise awareness of antibiotic resistance and to provide insight on the patient perspective.

Raising awareness

With the end of the pandemic, 2022 saw a reduction in our website traffic and higher number of Covid and vaccine-related visits dropped. Despite this we had over 350,000 users of the website in 2022 and were proud to have continued to develop the content on our website, particularly in relation to patient-related health information.

During the year we succeeded in maintaining good media coverage (see above for some key examples) and were able to secure key articles in both the mainstream and trade press.

Our communications and campaigns were supported by our vibrant social media activity and by the end of 2022, we grew our Facebook following to 1,553 followers, Twitter to 5,241, Instagram to 707 and LinkedIn to 2,475.

Fundraising

2022 was another challenging year for fundraising. Income streams impacted by lockdown proved slow to bounce back (face-to-face community fundraising and sporting events), and the cost-of-living crisis once again focused funders’ attention on frontline emergency relief charities – while the general public had less available funds to donate to charity. The need for charities to invest in other income streams to make up shortfalls resulted in increased competition for funding from Trusts and Foundations. Across the sector, small and medium-sized charities found maintaining income difficult.

Notwithstanding, with great resilience and a renewed focus, we managed to grow income to in-excess of prepandemic levels. As always, we are enormously grateful to those who donated and volunteered on our behalf. Without their support we would not be able to continue our vital work.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

Fundraising (continued)

Fundraising highlights in 2022 include:

FINANCIAL REVIEW

The consolidated gross income for the year was £399,824 (2021: £409,696). The previous year’s income figure included donated services of £80,771, however, there were no donated services during 2022, and thus raised funds have increased from £328,925 (2021) to the current figure of £399,824 in 2022.

The consolidated net movement in funds for the year was a surplus of £250 (2021: deficit of £41,069).

Going concern

Management works to an annual budget and has prepared a forecast to the end of December 2023, along with an outline budget and projections for 2024. These are used by management to ensure the organisation has sufficient funds in place to manage working capital in both the short term and longer term and enables the planning of resource allocation, organisational strategy, sustainability, and development.

Management has identified strong fundraising performance as crucial to positive cash flow management, particularly in relation to unrestricted funding. Fundraising plans and activities and future expenditure management have been reviewed, so as to better understand the impact of varying cashflows on the solvency of the organisation. Budgets have been set in line with the parameters in that review and are sufficient to ensure the organisation has adequate funds to meet its cash flow obligations to the end of 2024. Performance during 2021 highlighted the need to improve financial management and reporting processes within the organisation so that they were focused on agreed fundraising priorities and effective and responsive expenditure management. These areas were reviewed and addressed by trustees and the organisation’s management during 2022, with a forward plan developed, with a particular focus on building unrestricted reserves during 2023, while ensuring contingency plans are in place to manage any fundraising shortfalls. These measures have started to prove successful in 2023, although ongoing monitoring and review are required to ensure their sustainability and focus. With these measures in place, trustees are confident about the organisation’s ability to continue in operation for at least twelve months from the date of the financial statements.

On this basis, together with the unrestricted funding received in the first eight months of 2023, the Board has approved the preparation of the financial statements on the going concern basis.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

Reserves policy

The trustees aim to maintain a minimum of free reserves equal to 3 months’ core expenditure (approximately £60,000). Any funds over this sum will be used to fund the charity’s objects.

The year-end level of free reserves was £30,237 (2021: £33,884). As noted above, organisational plans have been implemented to grow unrestricted reserves, including building a predictable and reliable funding base from individual and regular giving, as well as with community and corporate support, and through refocusing some of our fundraising priorities on essential expenditure related to our core mission. These are beginning to deliver promising results in 2023.

PLANS FOR FUTURE PERIODS

With a change of chief executive officers during 2022 – the retirement of our founder, Professor Colin Garner, in August, and the arrival of Jonathan Pearce in August (as reported in last year’s report and accounts) – we carried out a review of our strategic plan and business priorities towards the end of the year. The Board agreed to retain the three overarching goals we had set out in our original five-year strategy as approved in 2021, however, within those goals we decided to prioritise and focus our work, particularly on the patients with urinary tract infections (UTIs) that account for approximately 60% of our support services. Accordingly, we have set out our new objectives as follows:

Goal 1: Drive forward innovative solutions to drug-resistant infections

Through collaboration, we will advance research by supporting the development of at least one antibioticresistance breaker, antibiotic alternative or combination therapy towards clinical use. We will support underfunded areas of antimicrobial (AMR) research and progress the next generation of researchers in the AMR field.

We will do this by:

Short Term (1–3 years)

Goal 2: Improve the lives of people affected by drug-resistant infections

We aim to improve the lives of patients and their families by acting as a source of trustworthy information. We will work to reach more patients and build the strength of this patient community so that their collective voice can be heard and to ensure that our services best fit their needs.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

PLANS FOR FUTURE PERIODS (continued)

We will do this by:

Short Term (1–3 years):

Goal 3: Raise awareness about the impact of drug-resistant infections

We will work to raise the profile of the human impact of drug-resistant infections. We will partner with other organisations to run awareness campaigns and lobby government to drive the policy changes needed to reduce the spread of drug-resistant infections.

We will do this by:

Short Term (1–3 years):

Long Term (4+ years)

Behind each of these goals and priorities we have identified a set of enablers, milestones and performance indicators, which we have designed to guide our approaches to potential funders and supporters. In order to achieve our goals, we need to reach more people and organisations willing to support us in the fight against antibiotic resistance. Key to building that platform of financial support are:

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

REPORT OF THE BOARD OF TRUSTEES

PLANS FOR FUTURE PERIODS (continued)

It is a challenging task, but an important one. We hope you will join us in tackling one of the most important health issues of modern times.

TRUSTEES’ RESPONSIBILITIES IN RELATION TO THE FINANCIAL STATEMENTS

The trustees are responsible for preparing the Report of the Board of Trustees’ and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

The law applicable to charities in England & Wales requires the trustees to prepare financial statements for each financial year which give a true and fair view of the state of affairs of the charity and of income and expenditure of the charity for that period. In preparing these financial statements, the trustees are required to:

The trustees are responsible for keeping proper accounting records that disclose with reasonable accuracy at any time the financial position of the charity and enable them to ensure that the financial statements comply with the Charities Act 2011, the Charity (Accounts and Reports) Regulations 2008 and the provisions of the constitution. They are also responsible for safeguarding the assets of the charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

The trustees are responsible for the maintenance and integrity of the charity and financial information included on the charity’s website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions.

Approved by the trustees on 6 September 2023 and signed on their behalf by:

Simon Dukes Signed on 15/09/23 @ 13:36

………………………………………………………..

Mr S Dukes – Chair

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

INDEPENDENT EXAMINER'S REPORT TO THE TRUSTEES

I report to the charity trustees on my examination of the accounts of the charity for the year ended 31 December 2022 which comprise the statement of financial activities, balance sheet and relevant notes.

Responsibilities and basis of report

As the charity’s trustees you are responsible for the preparation of the accounts in accordance with the requirements of the Charities Act 2011 (“the Act”).

I report in respect of my examination of the charity’s accounts carried out under section 145 of the Act and in carrying out my examination I have followed all the applicable directions given by the Charity Commission under section 145(5)(b) of the Act.

Independent examiner’s statement

Since the charity’s gross income exceeded £250,000 your examiner must be a member of a body listed in section 145 of the Act. I confirm that I am qualified to undertake the examination because I am a member of ICAEW and ACCA.

I have completed my examination. I confirm that no material matters have come to my attention in connection with the examination giving me cause to believe that in any material respect:

  1. accounting records were not kept in respect of the charity as required by section 130 of the Act; or

  2. the accounts do not accord with those records; or

  3. the accounts do not comply with the applicable requirements concerning the form and content of accounts set out in the Charities (Accounts and Reports) Regulations 2008 other than any requirement that the accounts give a ‘true and fair view’ which is not a matter considered as part of an independent examination.

I have no concerns and have come across no other matters in connection with the examination to which attention should be drawn in this report in order to enable a proper understanding of the accounts to be reached.

N P Clemit Signed on 18/09/23 @ 11:22

Mr N Clemit ACA, FCCA JWPCreers LLP Chartered Accountants Genesis 5 Church Lane Heslington York YO10 5DQ

19 September 2023

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

CONSOLIDATED STATEMENT OF FINANCIAL ACTIVITIES FOR THE YEAR ENDED 31 DECEMBER 2022

2022 2022 2022 2021
Notes Unrestricted Restricted Total Total
funds funds funds funds
£ £ £ £
INCOME
Donations and legacies:
Donations and grants 2 56,044 10,660 66,704 62,900
Donated services 2 - - - 80,771
Charitable activities 107,278 186,755 294,033 236,893
Other trading activities:
Membership fees 3,745 - 3,745 2,174
Fundraising events 33,934 1,408 35,342 26,958
______ ______ ______ ______
Total income 201,001 198,823 399,824 409,696
EXPENDITURE
Raising funds
Fundraising costs 3 80,108 4,645 84,753 98,064
Donated services - - - 18,420
Charitable activities
Charitable activities 4 291,470 23,351 314,821 267,686
Donated services - - - 62,351
______ ______ ______ ______
Total expenditure 371,578 27,996 399,574 446,521
Net (expenditure)/ income (170,577) 170,827 250 (36,825)
Transfer between funds 8,9 165,466 (165,466) - -
Corporation tax receivable - - - (4,244)
______ ______ ______ ______
Net movement in funds (5,111) 5,361 250 (41,069)
Fund balance brought forward at
1 January 2022 35,348 405,481 440,829 481,898
______ ______ ______ ______
Fund balance carried forward at
31 December 2022 8,9 30,237 410,842 441,079 440,829

All income and expenditure derives from continuing activities.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

CONSOLIDATED STATEMENT OF FINANCIAL ACTIVITIES FOR THE YEAR ENDED 31 DECEMBER 2022

2021 2021 2021
Notes Unrestricted Restricted Total
funds funds funds
£ £ £
INCOME
Donations and legacies:
Donations and grants 2 59,721 3,179 62,900
Donated services 2 80,771 - 80,771
Charitable activities 59,186 177,707 236,893
Other trading activities:
Membership fees 2,174 - 2,174
Fundraising events 26,958 - 26,958
______ ______ ______
Total income 228,810 180,886 409,696
EXPENDITURE
Raising funds
Fundraising costs 3 98,064 - 98,064
Donated services 18,420 - 18,420
Charitable activities
Charitable activities 4 262,556 5,130 267,686
Donated services 62,351 - 62,351
______ ______ ______
Total expenditure 441,391 5,130 446,521
Net (expenditure)/ income (212,581) 175,756 (36,825)
Transfer between funds 8,9 103,642 (103,642) -
Corporation tax receivable (4,244) - (4,244)
______ ______ ______
Net movement in funds (113,183) 72,114 (41,069)
Fund balance brought forward at
1 January 2021 148,531 333,367 481,898
______ ______ ______
Fund balance carried forward at
31 December 2021 8,9 35,348 405,481 440,829

All income and expenditure derives from continuing activities.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

BALANCE SHEETS AT 31 DECEMBER 2022

Notes Consolidated Consolidated Charity only
2022 2021 2022 2021
£ £ £ £
FIXED ASSETS
Investments 5 - - 1 1
CURRENT ASSETS
Debtors and prepayments 6 561 4,105 561 1,711
Cash at bank and in hand 463,366 458,794 462,816 458,628
______ ______ ______ ______
463,927 462,899 463,377 460,339
LIABILITIES: Amounts falling due
within one year 7 (22,848) (22,070) (22,299) (20,975)
______ ______ ______ ______
NET CURRENT ASSETS 441,079 440,829 441,078 439,364
______ ______ ______ ______
NET ASSETS 441,079 440,829 441,079 439,365
THE FUNDS OF THE CHARITY
Unrestricted funds 9 30,237 35,348 30,237 33,884
Restricted funds 8 410,842 405,481 410,842 405,481
______ ______ ______ ______
TOTAL CHARITY FUNDS 441,079 440,829 441,079 439,365

Approved by the trustees on 6 September 2023 and signed on their behalf by:

Simon Dukes Signed on 15/09/23 @ 13:36

………………………………………………………………….

Mr S Dukes - Chair

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

1. ACCOUNTING POLICIES

Basis of accounting

Antibiotic Research UK – Developing New Antibiotics is a charitable incorporated organisation in England. The address of the registered office is given in the charity information within the trustees’ report of these financial statements.

The charity constitutes a public benefit entity as defined by FRS 102. The financial statements have been prepared in accordance with Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland issued in October 2019, the Financial Reporting Standard applicable in the United Kingdom and Republic of Ireland (FRS 102), the Charities Act 2011, and UK Generally Accepted Accounting Practice.

The financial statements have been prepared to give a ‘true and fair’ view and have departed from the Charities (Accounts and Reports) Regulations 2008 only to the extent required to provide a ‘true and fair view’. This departure has involved following the Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland issued in October 2019 rather than the Accounting and Reporting by Charities: Statement of Recommended Practice effective from 1 April 2005 which has since been withdrawn.

The financial statements are prepared on a going concern basis under the historical cost convention, modified to include certain items at fair value. The financial statements are prepared in sterling which is the functional currency of the charity.

The significant accounting policies applied in the preparation of these financial statements are set out below. These policies have been consistently applied to all years presented unless otherwise stated.

Group financial statements

These financial statements consolidate the results of the charity and its wholly owned subsidiary ANTRUK Enterprises Limited on a line by line basis.

The gross income of the charity for the year was £399,824 and the result of the charity for the year was net surplus of £1,714.

Going Concern

The charity's financial statements are prepared on a going concern basis on the grounds that current and future sources of funding or support will be more than adequate for the charity's needs. The trustees have considered a period of twelve months from the date of approval of the financial statements and believe that no further disclosures relating to the charity's ability to continue as a going concern need to be made in the financial statements.

Fund accounting

Unrestricted funds are funds which are available for use at the discretion of the trustees in furtherance of the general objectives of the charity.

Restricted funds are donations which the donor has specified are to be solely used for particular areas of the charity’s work or for specific projects being undertaken by the charity.

Income

All income is included in the statement of financial activities when the charity is legally entitled to the income and the amount can be quantified with reasonable accuracy.

Donated services are accounted for at a reasonable estimate of their value to the charity and are included in the statement of financial activities as income when receivable.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

1. ACCOUNTING POLICIES (Continued)

Expenditure

All expenditure is accounted for on an accruals basis and has been classified under headings that aggregate all costs related to the category.

Raising funds relates to costs incurred directly to generate donations. Charitable expenditure comprises those costs incurred by the charity in pursuit of its charitable object. Grants payable are charged in the year when the offer is conveyed to the recipient.

Tangible fixed assets and depreciation

Individual fixed assets costing £500 or more are capitalised at cost. Currently Antibiotic Research UK has no tangible fixed assets.

Debtors

Trade and other debtors are recognised at the settlement amount due. Prepayments are valued at the amount net of any trade discounts due.

Cash at bank and in hand

Cash at bank and cash in hand includes cash and short term highly liquid investments with a short maturity of three months or less from the date of acquisition or opening of the deposit or similar account.

Creditors and provisions

Creditors and provisions are recognised where the charity has a present obligation resulting from a past event that will probably result in the transfer of funds to a third party and the amount due to settle the obligation can be measured or estimated reliably. Creditors and provisions are normally recognised at their settlement amount.

Financial instruments

The charity only has financial assets and financial liabilities of a kind that qualify as basic financial instruments. Basic financial instruments are initially recognised at transaction value and subsequently measured at their settlement value with the exception of bank loans which are subsequently measured at amortised cost using the effective interest method.

2. DONATIONS AND GRANTS

2022 2022 2022 2021 2021 2021
Unrestricted Restricted Total Unrestricted Restricted Total
Funds Funds Funds Funds Funds Funds
£ £ £ £ £ £
Donations 12,992 - 12,992 25,720 - 25,720
Gift Aid 13,316 - 13,316 12,473 - 12,473
Online giving 29,736 10,660 40,396 21,528 3,179 24,707
______ ______ ______ ______ ______ ______
56,044 10,660 66,704 59,721 3,179 62,900
Donated services - - - 80,771 - 80,771
______ ______ ______ ______ ______ ______
56,044 10,660 66,704 140,492 3,179 143,671

Included in donations in the prior year were proceeds of £6,933 gained from the dispersal of donated shares received during the year.

Donated services in the prior year were legal services provided pro bono by Ashurst LLP, London and professional services by Costello Medical, Bow House Digital and ASF Alison Staples Fundraiser.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

3. RAISING FUNDS EXPENDITURE

2022 2022 2022 2021 2021 2021
Unrestricted Restricted Total Unrestricted Restricted Total
Funds Funds Funds Funds Funds Funds
£ £ £ £ £ £
Fundraiser fees 77,810 4,615 82,425 109,494 - 109,494
Fundraising expenses 2,298 30 2,328 6,990 - 6,990
______ ______ ______ ______ ______ ______
80,108 4,645 84,753 116,484 - 116,484

Fundraising fees includes £nil (2021: £18,420) of donated services.

4. CHARITABLE ACTIVITIES

2022 2022 2022 2021 2021 2021
Unrestricted Restricted Total Unrestricted Restricted Total
Funds Funds Funds Funds Funds Funds
£ £ £ £ £ £
Trading subsidiary 5 185,441 - 185,441 120,359 - 120,359
Patient support costs - 5,364 5,364 - 3,519 3,519
Legal and professional 54,754 4,921 59,675 143,192 1,000 144,192
fees
Consultancy fees 26,935 4,546 31,481 31,171 611 31,782
Accountancy 9,146 - 9,146 9,552 - 9,552
Printing, postage and 375 586 961 1,522 - 1,522
stationery
Website and IT 6,642 90 6,732 12,926 - 12,926
Phone and internet 198 - 198 102 - 102
Computer and software 4,008 - 4,008 435 - 435
Insurance 407 - 407 578 - 578
Travel and subsistence 1,386 224 1,610 189 - 189
Bank and CAF charges 1,293 - 1,293 1,221 - 1,221
Recruitment costs 885 - 885 969 - 969
Annual lecture costs - 4,494 4,494 2,691 - 2,691
Student engagement - 3,126 3,126 - - -
sponsorship work
______ ______ ______ ______ ______ ______
291,470 23,351 314,821 324,907 5,130 330,037

Legal and professional fees include £nil (2021: £62,351) of donated services.

Accountancy fees includes payments to the independent examiner of £2,826 (2021: £2,712) for the independent examination and £960 (2021: £1,260) for other accountancy services.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

5. TRADING SUBSIDIARY

The wholly owned trading subsidiary, ANTRUK Enterprises Ltd (company number: 10396024), which was incorporated in England and Wales on 27 September 2016, provides funding to research projects concerning antibiotics. The charity owns the entire issued share capital of 1 ordinary share of £1. A summary of the trading results is shown below. Monies are granted from the charity to the trading subsidiary to fund research projects.

The activities of the subsidiary are being transferred to the charity and therefore are discontinuing within the subsidiary but continuing within the group.

Summary profit and loss account

2022 2021
£ £
Research costs and administration expenses (185,441) (120,359)
Income from group undertakings 183,977 120,361
Corporation tax (payable)/ repayable - (4,244)
______ ______
Retained in subsidiary (1,464) (4,242)
The assets and liabilities of the subsidiary were:
Current assets 5,109 4,654
Creditors: amounts falling due within one year (5,108) (3,189)
______ ______
Total net assets 1 1,465
______ ______
Aggregate share capital and reserves 1 1,465

Included within research costs are grants made to 6 institutions for £101,437. There were no grants made to individuals.

6. DEBTORS

7.

Prepayments and accrued income
VAT
CREDITORS DUE WITHIN ONE YEAR
Accounts payable
Accruals
Amounts owed to group undertakings
2022
Group
£
561
-
__
561
2022
Group
£
6,428
16,420
-
____
22,848
2021
Group
£
1,711
2,394
__
4,105
2021
Group
£
-
22,070
-
____
22,070
2022
Charity
£
561
-
__
561
2022
Charity
£
6,428
11,312
4,559
____
22,299
2021
Charity
£
1,711
-
__
1,711
2021
Charity
£
-
18,881
2,094
____
20,975

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

8. RESTRICTED FUNDS

RESTRICTED FUNDS
Antibiotic Resistance Breakers
Patient Support
Combined Research 2019
Test Discs
Combined Research 2019
including Test Discs
Small Research Grants
Mutate Trial
Big Give 2020 programmes
Combined Research 2020
including mutate trial &
non-antibiotic alternatives
Combined Research 2021
TNL England
TNL Wales
TNL Northern Ireland
PhD student support
Reducing Antibiotic Prescribing
Student Programme
Annual Lecture
Antibiotic Resistance Breakers
Patient Support
Combined Research 2019
Test Discs
Combined Research 2019
including Test Discs
Small Research Grants
Mutate Trial
Big Give 2020 programmes
Combined Research 2020
including mutate trial &
non-antibiotic alternatives
Combined Research 2021
TNL Scotland
TNL England
TNL Wales
TNL Northern Ireland
PhD student support
Reducing Antibiotic Prescribing
At
1.1.22
£
68,879
13,097
54,419
54,090
62,824
25,000
8,457
18,075
19,049
27,795
9,135
4,101
2,443
27,500
10,617
-
-
_
405,481
At
1.1.21
£
68,879
-
55,030
64,269
62,824
25,000
-
18,075
19,049
-
2,017
18,224
-
-
-
-
_
333,367
2022
Income
Expenditure
£
£
-
-
15,620
(6,269)
-
-
-
-
-
-
19,710
-
26,200
-
-
-
-
-
-
-
57,582
(9,106)
-
-
-
-
27,500
(325)
38,461
(130)
3,750
(3,126)
10,000
(9,040)
_
__
198,823
(27,996)
2021
Income
Expenditure
£
£
-
-
19,387
(4,519)
-
(611)
-
-
-
-
-
48,812
-
-
-
-
-
51,727
-
5,976
-
8,819
-
4,593
-
2,736
-
27,500
-
11,336
-
_
____
180,886
(5,130)
At
31.12.22
£
73,961
8,632
-
54,090
43,940
48,372
34,657
-
-
-
40,865
4,101
2,443
52,175
47,732
(126)
-
_
410,842
At
31.12.21
£
68,879
13,097
54,419
54,090
62,824
25,000
8,457
18,075
19,049
27,795
-
9,135
4,101
2,443
27,500
10,617
_
405,481

Transfer
£
5,082
(13,816)
(54,419)
-
(18,884)
3,662
-
(18,075)
(19,049)
(27,795)
(16,746)
-
-
(2,500)
(1,216)
(750)
(960)
______
(165,466)

Transfer
£
-
(1,771)
-
(10,179)
-
-
(40,355)
-
-
(23,932)
(7,993)
(17,908)
(492)
(293)
-
(719)
______
(103,642)

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

8. RESTRICTED FUNDS (Continued)

Antibiotic Resistance Breakers (ARB) fund represents monies donated to fund the research into ARBs, this incorporates the Holbeck Charitable Trust funding as it was for the same cause.

Patient Support fund represents monies donated to fund a patient support officer whose role will be to develop a portfolio of patient support resources for people affected by antimicrobial resistance.

Combined Research 2019 fund represents monies donated towards a specific application for funds from Antibiotics Research that identified expenditure across three programmes. Research into new antibiotic therapies, research into non-antibiotic alternatives (Diamond), and a small research grants scheme.

Test Discs funds represents monies donated towards the next stage of research. The manufacture and circulation to partners of a test disk sensitivity kit for further testing.

Combined Research 2019 Including Test Discs fund represents monies donated towards both of the above two funds.

Small Research Grants fund represents monies donated towards the small research grants programmes.

Mutate Trial fund represents monies donated for the next phase of the MUTATE research programme which is working with hospital microbiology labs in a round robin evaluation of cefepime / sulbactam test discs.

Big Give 2020 Combined Projects fund represents monies donated through the online platform Big Give. Antibiotic Research identified the expenditure would cover patient support, original antibiotic resistance breakers and the small grants programmes.

Combined Research 2020 Including Mutate Trial & Non-Antibiotic Alternatives fund represents monies donated to the above 2020 combination and includes expenditure on Non-Antibiotic alternatives.

Combined Research 2021 fund represents monies donated towards small research grants and early careers development awards.

TNL Scotland (2021 only) fund represents a National Lottery Award, monies donated are to be used to give Scottish Support Network for People Affected by antibiotic resistant infections in Aberdeen.

TNL England fund represents a National Lottery, monies donated are to be used for national support network for people affected by antibiotic resistant infections in England.

TNL Wales fund represents a National Lottery, monies donated are to be used for national support network for people affected by antibiotic resistant infections in Wales.

TNL Northern Ireland fund represents a National Lottery, monies donated are to be used for national support network for people affected by antibiotic resistant infections in Northern Ireland.

PhD student support fund represents monies donated by the Troutsdale Trust to support a PhD student.

Reducing Antibiotic Prescribing through triaging using Point of Care testing fund represents monies donated for the Study Protocol Development and planning for the scaled up roll out of the study.

Student Programme represents monies donated to further engagement with university students across the UK through the development of a Student AMR Society Scheme and activities such as ‘The Great University Science Quiz’ (online).

Annual Lecture fund represents monies received from Pfizer towards the costs of the 2022 annual lecture.

The transfers represent the money spent in ANTRUK Enterprises Ltd on these projects. Also in 2022 there was a transfer from the Big Give 2020 Programmes fund to Antibiotic Resistance Breakers, Patient Support, Small Research Grants and Reducing Antibiotic Prescribing in line with the funding request.

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

9. UNRESTRICTED FUNDS

At
1.1.22
£
General unrestricted funds
33,884
Non-charitable trading funds
1,464
__
35,348
At
1.1.21
£
General unrestricted funds
142,825
Non-charitable trading funds
5,706
____
148,531
Income
Expenditure
Transfer
£
£
£
201,001
(186,137)
(18,511)
-
(185,441)
183,977
__
_

201,001
(371,578)
165,466
2021
Income
Expenditure
Transfer
£
£
£
228,810
(321,033) (16,718)
-
(120,358)
120,360


___
228,810
(441,391)
103,642
Tax
£
-
-
______
-
At
31.12.22
£
30,237
-
__
30,237
At
31.12.21
£
33,884
1,464
____
35,348
Tax
£
-
(4,244)
______
(4,244)

The transfers in both years represents the funds (both restricted for the projects and unrestricted for general expenses) transferred into ANTRUK Enterprises Limited.

10. ANALYSIS OF NET ASSETS BETWEEN FUNDS

Fund balances at 31 December 2022 are represented by:
Unrestricted
Restricted
funds
funds
£
£
GROUP
Current assets
53,085
410,842
Creditors: amounts falling due in less than one year
(22,848)
-
__

Total net assets
30,237
410,842
CHARITY
Investments
1
-
Current assets
52,535
410,842
Creditors: amounts falling due in less than one year
(22,299)
-

__
Total net assets
30,237
410,842
Total
£
463,927
(22,848)
__
441,079
1
463,377
(22,299)
____
441,079

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ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

10. ANALYSIS OF NET ASSETS BETWEEN FUNDS (Continued)

Fund balances at 31 December 2021 are represented by:
Unrestricted
Restricted
funds
funds
£
£
GROUP
Current assets
57,418
405,481
Creditors: amounts falling due in less than one year
(22,070)
-
__

Total net assets
35,348
405,481
CHARITY
Investments
1
-
Current assets
54,858
405,481
Creditors: amounts falling due in less than one year
(20,975)
-

__
Total net assets
33,884
405,481
Total
£
462,899
(22,070)
__
440,829
1
460,339
(20,975)
____
439,365

11. TRUSTEES’ REMUNERATION AND EXPENSES

No remuneration was paid or payable directly or indirectly out of the funds of the charity for the period to any trustee or to any person or persons known to be connected with any of them for acting as a trustee.

No trustees were reimbursed expenses (2021: no trustees).

12. RELATED PARTY TRANSACTIONS

Garner Consulting Services received £18,965 (2021: £31,782) for consultancy services and received £18,965 (2021: £31,782) for research project management costs from ANTRUK Enterprises Ltd. As ANTRUK Enterprises Ltd was VAT registered for part of the year the net cost was £15,804. The total cost to the group was £34,798 (2021: £58,267). Professor C Garner (Chief Executive of Antibiotic Research UK until 31 July 2022) and his wife are the partners in Garner Consulting Services. Of this amount £nil was owed to Garner Consulting Services at the year end (2021: £5,419).

Telling Data Limited received £12,513 (2021: £nil) for consultancy services and received £11,458 (2021: £nil) for research project management costs from ANTRUK Enterprises Ltd. The total cost to the group was £23,971 (2021: £nil). Jonathan Pearce (Chief Executive of Antibiotic Research UK from 1 August 2022) is the sole director of Telling Data Limited. Of this amount £4,583 (2021: £nil) was owed to Telling Data Limited at the year end.

Azets of which J A Farmer is a partner received £5,833 (2021: £7,180) for accounting services.

Ashurst LLP, of which N Stalbow is a partner, have provided pro bono services to the value of £nil (2021: £1,536).

The aggregated donations made by the trustees were £380 (2021: £1,025).

Page 23

ANTIBIOTIC RESEARCH UK – DEVELOPING NEW ANTIBIOTICS

NOTES TO THE CONSOLIDATED ACCOUNTS - 31 DECEMBER 2022

13. GRANT COMMITMENTS

Grant expenditure (charitable activities) committed at 31 December 2022 was as follows:

Unrestricted Restricted
funds funds Total
£ £ £
At 1 January 2022 - 108,795 108,795
Commitments paid out - (56,523) (56,523)
Additional commitments - 232,315 232,315
______ _____ ______
At 31 December 2022 - 284,587 284,587

Grant income committed at 31 December 2022 was £60,000 within 1 year (2021: £30,000) and £nil within 2 years (2021: £30,000).

14. FUNDS HELD ON BEHALF OF OTHERS

Bark de Dragonboat
Triomph Race
£ £
Funds held at 1 January 2022 - -
Income received as agent 13,092 600
Expenditure paid as agent (13,092) (600)
______ ______
Funds held at 31 December 2022 - -

Antibiotic Research UK acted as an agent for funds relating to fundraising events. They had no control over the transactions that occurred. The transactions were recorded within their accounting software such that the funds could be identified.

Page 24