Charity r¢gistralion nurnber.. I l i2445 Wolfram Syndrome UK Annual Reporl and F'inunLial s￿leMen15 for the Ye8r Ended 28 FebNary 2025 I l(Trdson & Co Wision House I Wiston Avenue Worihing Vest Sussex BN147QL Wolfram Syndrome UK Contents Reference and Administrative Details Tr￿St¢¢￿' R¢tM)rt 2ti? Statcmcni of TrUS￿eS, Rcsponsibilitles Independent Examiner's Report 10 sthicmenl ofFinuniial Aolivili¥4 Balance Sh¢e¢ 13 Notes to the financial Statements 14to26 Wolfram Syndrome UK Referenc¢ and Admlnlstratlve Detai18 Chalrmxtt Mr J Isherwood Trusltts MrANye Prof'l. Elarrelt Ir P Lynch Mr J lshenvood Miss A Gardner Senior M4D4g¢ment l Leodershlp M￿.1" Lynch, Chief E.xecutive Team Dr G lyherwood PhD, Conlracis Manager ChArlty Reglslratlon Number 1152445 Thc charily is In¢oTPOTatcd in England and Wal¢s. 9 Church Wav .1 grrin8 W(Irihin¥ Wesi Susgex BN13 IHD Regtstèred Offle• Independ¢nt Ex*inlll¢r Hodson & Co Wislon Ilouse I Wi5ton Avenue Worthing Wcst Stss5CX BN14 7QL Pa8¢ 1 wdrram Syndrome UK Trustees, Report I'hc truslecs. Ivho 8r¢ directors for the purws¢s of ¢oMp￿Y law* present thc annual Yeport together w'ith the linancial statements and auditors, report of the ¢haritable coinpan). for the )'rar ended 28 F¢bruary 2025. Objectlves and *etlvltleJ Objeets amd all￿ Wolfram Syndrome (WS) is a 8eneti¢ diyorder cau5in8 Diabet¢s Insipidu& Diabetes M¢llilus, optic atrophy and dealness. 11411ects children and adulis and there is curreiitly no kn()iYn Lure. There are eurrenil> &round 143 r￿pIe diagnosed with WS in the UK. This number is rising [￿d expected lo reach 1711 due to Incr￿Sed genetic Ecsting and improvcments in the diasno$i5 of Woifrnm R¥lated Syndromc. WSUK cxisls lo mca th¢ need5 of tho WS communliy- the children: young pcoplc and adLlis affcctcd by WS and ihcir families. Duc lo thc rarc and und¢r-research¢d nature of this illness, dia¥no$is currenil>' takes 3-6 months and involY¢s 5everHI ihousand tests. There is ortly one recognis¢d ¢enlir of expertise for ehildr¢n, which is al Bimin8ham Children's H05piial IBLH),. ynd liir udulLN. dl Queen EliÉHheth HIi%piL41 IQEIII Birrninuhum. th¢￿r[)T¢. il 1% b¢lievul ihai muny may not be rew8nised. WSUK ralses funds w help flndn¢e further res¢ar¢h and through its tsnewsletters, Ivebsite and annual Conferen￿ incirase levc15 of &warcness, knowledge and understanding of th15 illness. These activit1¢5 benefit not only Ihose currenilv afte¢ted but a150 Ihose dia8noRd in the future ond th¢ir families, not least In $v$toirtin8 an enhan¢ed naLional (ocus on findin8 cITe¢live Ireatmenls and gn ¢v¢nlual ¢ur¢, ror Ihoyc ¢urr¢nil)' offc¢tcd ond thcir fllmilies. WSUK mainiains a voluntary rc8lYtLY W)d digiributes infomution about Its aims. objectives v4nd a¢iiviiies. WSLIK proi,Ides direct and practlcal benefit through infonnation. oo-goin8 tront-line support. advice and 8uidan¢e in¢luding pt the WS mulii.disciplinory clinics ai BCH, Further pra¢ti¥#l ttrtd ¢motion#l ben¢fit is prV￿id¢d by WSUK to fafftilies living with WS in ￿)¢ forni of an annual ¢onterence, activilies / proj¢cts lor specilic members L)t'lhe WS ¢ommuni¢y {e.8. WS allect¢d adulisl and virtual or in per%()n fyrnily / u)mmunity meeliny%4. As it is irnportanl for the WS ￿MMunity to have opportunliies lo mcel in beNeen Ihc annual ¢onf¢rences: WSUK aims io provlde socia1 ei'ents that enable members ofihe WS comrnunlty. build relationshlps and provide pccr support in a Sdfe and wel¢omin8 spa¢¢. This may include regular on-linc scssion5 for Small groups, and l or in person events or fomily days at venues around ihe couniry. It is Intended that WSUK in person events are or¥uni4vd ui litile or no ¢usi li)r l#milies ond individuals lil help mttximise p&rticipolion. In addition, WSUK will alm to organlse'knke A break" opportunitie8 for parent% ond carers at on off()rduble ets81. l Dr lh¢ bertefi( of¢u￿ent and fulure WS alT¢cled people the level ol'aivyrene55. debaie and research arnong the public and M'ithin the professional Community of medical praclilioners 15 raised throu8h a t)umLKr of dissemination aciivilics or8anis¢d throu8h WSUK, From the professional foruin5 initially or8allised at ih¢ BirminghHm Llinics. WSIIK ivill he able to idenlily p()tenlially valuable re.%earch OPPL)rtunilies Ihal il can support through its family nehi'ork and financi￿1).. The IVSUK iyebsite 15 also used to further dissemin&t¢ research resulis and publi¢auons, All these activities are aimd at benefilin8 all families re￿istered with WSUK without Any further restriction and regardles5 of their ability to contribute financially, At th¢ di5¢retion of th¢ tru3te¢'s, financial supFx)rt iiill be id¢d ivhere FX)verty 15 8 barrier lo benefiL. 'I'here will be no privaLe benefiLs LD An)"one frorn WSIIK other than &% a beneficiary of its Staled oims and activities, No detrim¢nt or hamj ivill ￿.1$¢ from carryinB out anv of the aims, objectivesor actiN'ilies of WSUK. Pag¢ 2 Wolfrani Syndrome UK Trustee$, Report Pmbllc benefll Tho Iru5t¢cs h8I'c rcf¢rr¢d io thc guidencc ￿nt)in¢d in thc Charity Commisison's 8cnci.al 8uidan¢¢ on public ncfil H'h¢n rcvicwin8 lh¢ ¢harit) s aims and obj¢ciivcs and in planning futurc a¢livitics. 'Ihe trustees confinn thE4t th¢y have complied with the requirements of sec(ion 17 of the Charities Act 2011 to have due re8ard to the publiL benefit guidan¢e publishid h), thL Charity, Cornm1￿l￿n Inr F.n8lartd ond Wales. Achlevements And perfornJAiiet WS Communlty Support During 2024121125, WSIIK u)nlinued ￿ pr()vide expert $uptx)rt aclivilies and %eTvi¥e,41o the WS communily. spec1t1¢￿1}, throu8h the folloivinB'. l. Con(racl ivith Birmin8hwn Women's and Children's NEIS foiindation Trust IB WC. NFisfT) to supp)n the WS clinic services for children 8nd younB people, In Oclobvr 2024, WSUK suLces5fully compleied the yecond year ofits conlracl with B WC N'HSFT lo suppon the W8 fvlulii-DisLiplin4ry 'feam (MDI'I Llini¥ ¥¢rviL'¢s. part of the NHS Englund Highly SpeL'idlised ServiLe. Yoi'idcd lo atT¢¢l¢d Children l young people IYPI, ond th¢ir pgrcnl carcrs ond wid¥r fomily mcmbcrs. At the end of Y2 li,e. O¢121124). the WSUK Family Supp()rt co.ordinator IFSC) was either supp)rtin8 or was o¢liv¢lv ¢n$o8¢d with the majority1~80Q/ol of Yp and th¢ir families, During Y2. th¢ FSC had d¢liv¢red or M'as a¢tively delivering a totdl of115 support issues (e,8. involvin8 an exiemal a8eE)cy or seivice or providing emotional 8UPPOrt lo parentil, whi¢h repr¢sents an increase of +40% compored with )'eor l. Durin8 Y2. 14 YP ond thelr fomilies recelved a home visit from the FSC. whlch was an InLrease of +13099 C'ompared iviih Yl. The rsc home visi¢s were Conducted for a variety of reayons such as Ihc YP WA5 & new r¢feTral lo th¢ BCH WS .service in Y2 vr wu5 seen at a virtual WS clinlc. Ely OOL 2024. lh¥ FSC11gd also sucl'esifully suppu1￿d lh¢ four WS MD'I. ¥liDiiS UI BCH. wl)i¥h werc all¥nd¥d by a ()1'25 YP, and li￿1￿ i'irtual ¢lini¢s l()r 8 YP133 YP in iOLdl,. 3 nfivhom ivere nLH' TelerrHl%l and Lheir wreni eareTS. For the Oct 2024 WS MDT clini¢. the FSC Secured the use of Ronald McDonald House (RMH) on the Sunda), evcnin8 before clinic tor YP dnd families lo meet each other and the FSC in a privote and welcoming spoce. Follo1vin￿ a posilive resFon¥¢ Irom famllics. the us¢ of RMI.I has been se¢ured lor the 2025 WS MDT Clinics. In late Augu%1 2024, WSIIK app()inLul o ￿nd pon•iime FSL Alonglide ihe fI￿L F.SC, exiendlng ihe expert support resources uvJilabl¢ to this community. Following this apwinimenl, eQ￿h YP and their family has tecn BllucutLbd d ILad FSC ttTr pruvidfy on-guing SUPPOrt bL)th during uuisidc LliniL, and knih FSCS will RtILnd each WS MDI. ¢lini¢s in pernon from 2025. Some of WSUK'S on-89ing activities conducted to support or infomi the WS community, continue w ftimi part ol'Lh¢ coniracl BWL NHSFf. namely - il Annual Lonl¢r¥nc¢. ill mangging the WSLIK dalabose. iiil WSUK website and iv) qunrterly E-Newsletters. Page 3 Wolfram Syndrome UK Trustees, Report Ln S¢pl¢mb¢r 2024, WSUK held a facc-to-face UK Annual Conferenee ai th¢ same VLttUe &8 2023 which caters for many of th¢ ￿MmUnItV'S needs. This event provided an opwbrtunity for members ol'th¢ WS community to connect with each other in wson and ¢nga8¢ with WS health prof¢5sionals in o non*¥linic s¢iting. A WS panel 85ion was h¢ld lor the firsl time in 2024 with 3 WS adults who dI￿U55¢d th¢ir e.xpcrienc¢s of living with WS. Iheir dail), lives and 8ns￿'er¢d queslions fTom the Iloor. l-his session was well received by &LLendecs and thcrelorc a youn8 person's pancl is being plartned lor the 2025 annual conterencc. Throughout the yeor, WSUK has continued to regularly update Ihe charity iv¢bsil¢ IhitP5.'/lwolfrnmsyndrome.co.ukll lo ensure that it provides the WS community wilh ac¢ural¢. current and finiil>'.triendly infom￿110Tr on Ws-related issues, u'hi¢h ib Inedicolly endorsed. In addition, WSUK has continued io deliver quarterly e•newsldter5 to all Iliose iii the WS communill, and its 5UPPOrter5 who elecl Lo r￿'¢lI￿e r¢¥ulyr updu(es. P.uLh nrivsletter ifLlud¢¥ Intom￿lI17n un u Nnbl¢ ()I'l(Ipi¢'s liir exumple: updote% lin the laiest research, including thL fREATWoltrarn clinical trial. Each newsletter is dillribuled b). ernail, uploaded on the WSUK ii'cbsitc, And shared vie WSUK social media. To hclp ¢nsur¢ th¢ C•newslctler is as Bccessiblc as Possible. visually impaired I Vll members who use a scrcen reader r¢ceiv¢ a t¢xt altemalive for any includ¢d iiTrag¢s. In addiÉion. an audio version is made available tlirough th¢ WSUK websiie and on social medi& and a lar8e tont prinled copy is p¢sted to a small number of m¢nibcrs. i¥hcre Specifically requested. 2, Fneused support for WS uffe¢ted adults. Durin8 202412Q25. (he Wsuk Aduli Support Co-ordinator IASCI conilnued to cn8ase with the WS at7e¢led Jdult community io provide on-goin8. focused 3LlPPOrt through ac(iviiies su¢h as',- i. Attendance at the WS Adult MDT ¢lini¢s at Quc¢n Bli/8￿1h Hospital IQEH). Durin8 202412025. the ASC all¢nd¢d fiv¢ W'S MD'I. elinics al QbH (83%) mel a 10181 of25 WS alTecied adults and iheir famil>, membtr￿ in person to better understand their CU￿ent situation, any ehallen8es, and on-going support nceds. Thiough attcndlng Ih¢sc clinics in wnon. Ihc ASC hAS also Lxtcnded thcir r¢lationship$ qth the adulr ¢lini¢ lead and oth¢r Inemkrs of the MDT team. ii, On-going front.line supwrl In addition to the WS Mf)I' clinic5, during 202412025, the ASC developed stronB Connections ii'ith +50Vo nf odylts gnd-67% ol. family niLmber5. '1'he ASL provided expert support with a r8n8e ofactivitie& in¢ludin8• bul noi Similed t(i.' 15+ emoiionul ivellbein8 5upp)rl Lalls. aiiuli so¢iul ￿re reliThil¥ Mf)T mttlin8s wilh exl¢rndl stakeholders. housing issue& clinical and medi￿1 queries, ond benefit queries. D}. Feb 2025, the ASC had condueted 8 home visils to help support WS affected adults And their families in p¢rson, The ASC home visits Mer¢ ¢onduci¢d for 8 varieiy of reasons including for ayample, the symptoms. health status Bnd / or commiinicatiOTI needs ot the WS allected aduli, whicli meant thJt a face-to.lace discussion mu¥h mor¢ valuable tiir i11vryonL￿ invvli'ed LY)mpured with u phiine cull Trr virtual m¢¥ling. Throu8h all thcse ￿tIl.{17c$. th¢ ASC conlinucd to build strong and truslcd rclationshipy with rn8ny WS affeclcd adults and their families. and intends ID eNpand and e%tend th¢se re[￿lOnShIpS during 2(i25126. Pa8e 4 Wolfram Syndrome UK Tru$tee$' Report Research l.'I'libA'I'Wolfr¥m clinical trial A tOtrLI of 63 chlldren> young people and adults were reeruited to the TREATWolfrom elinicAI trlol hcross Ihe UK and a( Ihrec other in(cmalional sit¢s. WSUK hhs prciiiously providcd funds Lo thi) trial to help 3UPPOrt patienl visit costs for UK participants. The final trial patienis coMple￿d iheir last visils in October 2024. Ail data due to be locked b>, thc end of De¢cmber 2024, but at the WSUK fjnancial year li,e. 28102120251, this had not been Bchieved due to de18ys by one of the Frencli siies. The final WSUK p4ym¢nt tD 5UPPUrt TREATWolfrllrn wai ori¥inally defertrAI folloiving patieni recruithient d¢lay5 duc to ihc coifiD pandcmic. During 2022123, Ihe trial l¢od ¢onfirnicd that addiliot)al tijnds would not bc r¢quir¢d for th¢ r¢maindcr of Lhe stud), and in addition. BnN' surplus funds would b¢ returned to WSUK on¢e rinol payments had been m&d¢. As su¢h: boih the finul payment and any surylus will remain re5trict¢d funds and M'ill be allocated to help support future clinical irials ¢onducted in th¢ UK or other research activities. 2. WSUK S¢ieniifi¢ Advisory Board In O¢lob¢r 2024 a second small 8rnnl w85 paid to a researL.h project b}. KU Leuven University in Belgium. loll()Ivin¥ u r¢L'ihmmLndali()n t)y ihv W'8IIK SLientiliL Adi'isory Buurd (SABI thul thi4 %Y()uILi bi u vuluubll project fur ihe charily l(> siiprx)rt if 4uffi¢leni funds ivere available. Thls pmlect wal ￿￿nJnded b}. WSUK and I'he Snow Foundaiion, USA. In J£muary 2025. the WSUK SAB met ￿ dlscuss the reJeaN'h proposals reLelved foi, th¢ small yanl fundln8 of £12,000 for the 2024125 finllncial year. A d¢¢ision wos rnad¢ lo pivard th¢5¢ funds to ts research proj¢d in Mvnlp¢li¢T Univ¢Tsity, France. Th¢ funds M'ill be r¢l¢8sed in the nexl WSUK linoncial vear {i.e. 2025120261 due to Ihe amendments to the paperMt)rk required by the 8iwII recipient. 3 WS Iniernaiionol Research Symp05ium IR October 2024, WSUK co.hosted the 9th WS Intematlonal Researchers Symp051Urn lrt Windsor. 33 global reseorcheTS and phomo representatives spent Thvo doys discussing their currenl ￿e&r6h projects ond ¢linic trials, 'lkne progr8mme specitiLall)' de5i8ned to gi￿¢ participants time to hear the preseniations. &sk questiuns and talk with ()Iher res¥archer5 inl()nn#lly between %e5.4i()ns, und hu5 re8ult¢d in wme new Li?11ob(Frdtii?ll5 be[￿e￿n global resear¢h lewns. The Symposium ended H'ith all poiti¢ipanis ¢ollaboraling on a plan to ctea¢e in upd&(ed i'crsion ol'clinieal GuidcliiiLS for Wollrom Syndromc witli a deodline for l ll Oclob¢r 2025, WS Global Aw'areness Dayp for distribution to m¢di¢al or8anis&lions, hcalihcarc profes5ional$ und oiher relevant ¥roup3 around the world, Page i Wolfram Syndrome UK Trustees, Report Fundralslng Consistent ii'ith previous years. fundrdising acliviti¢s ¥vere Londucted throughL)Ut th¢ vear by lh¥ WSUK tcum, Ihe WS communitv and its supportLrs. S'pecific examples include, bul arc not limited to.. Monthly don4liuns- Members of the WS community ond WSUK sUPPOrters wntinued with their regular rnonthly donations, i¥hi¢h wcrc 8re&tly rceeived and huB¢I)' apprcciatcd. ii. Local fundrnlsing events by WSUK supwrters- &%amplcs include.. - a local recruitm¢nl ¢ompany hosted a charity football match and a 6-a-side tournament 1s.ith l O teams durlng the year. WSUK attended each event to support the plavers, raise the awErene.5s of WS and highli8hi hom. (heir donaLions help this communily. iii. Communitv donoliuns- Throughout the year, memlkrs ol'thc WS community complctcd funLlraising ft¢tivitieJ or mod¢ donation5 to help suppoit the charity. Ex6rnples include: . Half m8rathons. an 81￿mIle ride for an 80th birthd4y, a Chrislmas klamper Draw. iv. Annual Golf Day event- 'Ihe I Ith WSUK Annual (yolf Day was held In July 2024. The pgrtiLlpatln8 trams, mwiy of whom have been involi'ed in prevlous event9, ogain raised a substanti&l an)ount of lunds for the oharity. . Sale of UK bT9nded liems- Similar ¥viih preipiou$ )'earn, items sueh as Christmas cards, waler bottle9 tmd pens wer¢ 501d through boih the WSUK wcbsllc and social media accounts, confcrence and al chariiy fLindraisin8 events. I'i. Chrislmas Hamper Raffle- In D¢L¢m￿'r 2024, a IoLal buutique reslaurnni held a hamper raffl¢ ol'100 Lilkets to rdisc £500. WSUK thanks evwone in th¢ WS Community and ils SUPF<)rters tor their continued $upport in helping the harily io raise funds lo delivcr its imponant work. 4 FINISHER IVS tilobal Aivareness Day l $1 Oc(ober 'I'he fourth WS (ylobal Awareness Dav look place on Uctober 1st 2024. WS related infomalion wo5 dislribuled tn slnhal OTgalli8atinn8 to help raise th¢ir awar¢n¢8s of the ciTrndilioll. W8IIK inteDd4 lo h()Id the fifth W8 Cilobal Am'llreness Day on 1st October 2025 ivhen il 15 iniended that the nem. Clinicol Guidelines for Wolfigm Syndrom¢ will be ai'ailable for dissemination to medi¢al practitioners 8lobally. TREATWOLFRAM Ps wy•w*ld• Pa8e 6 Wolfram SyDdrom¢ UK Trusteey, Report FinalleiAI review I'ot91 incoming resources for the ye4r were £121,22812024.' £130,399) wlth expendilure of £139:723 {2023.. £113,865). Oi'eroll. there wos a deficit for the year of £18,495 {2024-. surplus £22,534). Urtrestricted funds at the >'¢arvend were £28,50812023.. £37:5691 and the restricted funds ivere £84.023 (2023: £93,457). Toial iunds for tho year MEre £112,531 (202].. £131,026). Pollcy on reserv The knwstees hai'e examinoj the ¢hority'5 requirements for r¢s¢rves in li8hi ofthc main risks to the organisation. Th¢ trustccs considcr thai thc prcscnt Ici'cl of ￿ndIng will bc adcqu4t¢ to Support thc continuation of the charity nd for li to fulfil ils obli8&1ion& Inveslmentpolley objedlves ubjeL'Ls ul'ih¥ Lumpdn). uuihuri.s¢.% IL L(1 ini und dedl wilh miin¥y.¥ n(Il imm¢didlely requi￿￿ fur li¥ purpose$ in and up)n such inv¢sunents securities and pmperti. os mgy be thoughi tit. GDIDK con¢ern The charity has reviewed i(,$ financial perform8n¢e and g?en¢r81 r¢s¢rves posiiion. The charity hus adequate tinanciol r¢sour¢¢q and 1$ able tn mana8¢ it'8 bu4ines8 risks. l-hL chaTity's planniTr8 proce¥s has laken int(> considera¢ion the cuiyent economi¢ climate and its wtenliul imp&et on th¢ vBrious sources of ineome and planned ¢xp¥nJilur¢. Tokin8 In￿ account all fActt)rs th¢ charity ha5 r¢450n8bl¢ oxpfftstion that il has ad¢quDte resQUW¢5 to coniinuo in operational existence for Ihe foreseeable tl]tur¢ and beli¢v¢ th41 there are no mat¢rial uncertaintie5 that call into the charity's abilit>. to ¢L)ntinu¢ in operation. Accordin8lyi the accounts huvc bc¢n prcpard on Ihc basis thal Ihc ¢haril)'1s & 8oin8 ¥on¢¢rn. Structiirei gov•rnaDee and mall&gemellt Jyulure 018ov*rnlng doeliment Wolfram Syndromc UK is e Lh4ritabl¢ Inoorpor4t¢d Or8Anisaiion r¢sisl¢red on 17 Junc 2013 with Ihc Ch&riry Commisslon of Cn8land #nd Wales (no. 1152445). The chgrity's worklng name18 WSIIK. Tru5ttts MrANye Prol'T B4rrell Mr P Lynch Mr J Isherwood Nliss A G￿rdner Mr N Misty (re5i8n¢d 4 Jun¢ 2024) Recrnllmeni uppolfttWAI ollrmslees Th¢ Board has the power to appoint udditionol tnistees &8 1¢ considers fit io th so. Trlone of the trustees hos any beneficiAI interest in tl)e charity. Pa8e 7 Wolfram Syndrome UK Truste¢y' Report l#du¢ilon ￿ndtraInINg oflruslees Poicnilal irustees are s¢l¢ctcd on the basis of thelr pcr50nal qualitics and the CL)mplcx issucs Involvcd. A spcciality linking to charity nLcds is also soughi. Ncw Iru51ccs are made familiar ivith Ihc charity vision. operation and goals by diologue with ¢¥isiing personrtel and proi'ision of minute5 and other literature pertdining lo choritv aclivily. All tntstees are Hlready familiar with the practical work lif the chority. NeN' Iru5tees alE encouraged to attend all m&na8ement committee me¢tings. Shon rrainin8 scssion5 {if rcquircdl lo fornillarl* nov trustees wilh the charity and the context within which il operates are proiiided. Orgftntsollonalslrwcthre 'lThe charily is or88n1s￿ so Ihal ihc Iruslceg mcci rc8ulariy lo m&na8¢ ils Qtrairs. 'I'hc IN54C¢S m¢LL al Icosl 4uarlerly ivith addiilon&l m¢etings 05 r¢4uired. The ¢harii} is Ove￿¢C￿ by the Iruslees. supFN)rttd by volunteers. The orBanisAiion op¢rat¢s In thc UK from prcmiscs in Church Road. Worthin8. Key strate8ic and administrative deeislons gre made by agreem¢nl ot'the trusiees, and d¢le8ated as appropriate. Day lo day m8na8¢m¢nl olihe chHrily is dele8al¢d to Ihc Chief Execulive, Mr5 Tracy Lyn¢h. Finanel#l In5trum¢n¢$ ObJ¢dlves andpollcle The chariry only h05 financial assets and finAn¢ial liabilities of a kind that qU81ify as basic fln&ncial instrum¢nis, B48iL linoni'iul inslrument4 ure tniiiully reco8ni5ed UL iransu¥lion value und >ubwuenily meusured al their seiilemenE value with the exception Trf bank loans whlch al'e subsequently measured UT amorti8ed cost using Ihe cffcclivc int¥rcsl m¢thod, Dlsclosmre of Snform&tlnn to Audltor Ejch trus¢￿ has tsk¢n sl¢p$ that they ou8ht to hai'e ts]ken 8S a trust¢¢ in ord¢r lo mak¢ thcm5¢1v¢s awar¢ of any relevant audit information and to establish thAt the charity'5 auditor 15 8ware of that inforn)&tion, The I￿ste¢S Lonlimi thmt there iy no rvleiiomi inlorm&tion that they krn)iY ol'llnd ol. ¥vhi¢h they knom. the yuditor 15 unam'are. annual re￿rt apwuwed by the trustees of the ch8ritv on Si8ned on its behalf by: i*fr J IslJer%vood Chdimiun and irusiee Pag¥ 8 Wolfram Syndrome UK Statement of Trustees, Responsibilities The Irusiees are responsible lor preparing the trustees, repjrt ond the tinancial statemcnts in accordance with appliLabl¥ laiir and Unitcd Kingdom A¢¢ounlin8 StandaTd5 (United Kingdom G¢n¢rally A¢Lepted Accounung Practice). Ch￿11} .SORP requir¢s ih¢ tiv￿¢￿5 1() prepar¢ tinunLidl ¥i#iemenls fur eulh finunciul &i-ar. Thg tru.%t¢¢% mu.%t niTrt opproille the fin8nci&l statements unles5 they are 9atisfied that the), 8iiye a true and foir vieiv ot.the ¢hori1!' and of thc incomin8 rcsourc¢$ and dpplication of resour¢c$. including its incomc and ¢xpcndiiur¢. of lh¢ charity for that period. In preparin8 these flnancial 5t&lements. the IJvstee5 are requli'ed io: s¢l¢¢¢ suitable accounting policies and appl). them consistently.. observe th¢ mcthod$ and prfn¢iples in the Charilics SORP. make judgemen($ and e5timaies that ure reosonable and p￿d￿n4 stale wheiher &ppll¢able accounting standords hai'e b.en folloived. subje¢l to pny Inater5al departures disclosed and explained in the fin&ncial 5tatcments,' and prepare th¢ tinanci81 stateinen¢s on the goin8 concern bhsis unless It is inapprnpriete to presume that the ¢harity M'ill ¢ontinu¢ in business. lThe Irusie¢$ gre responsible for keeping accounting records that disclose ivith relsongble occuracy at any time ¢hc finuncial wsition of th¢ tharity. They are &lso rc5ponsiblc for 5afe8uordin8 thc aS￿ts of th¢ ¢h4riLy ond h¢n¢e for taklng re￿nable sleps for the prei'ention and dLiection uf fraud and other iTre8ularitlcs. Approved by Ihc trusl¢c$ of ihc charity on £Y/i.i/tsand Signed on its bchalf by: Mr shenvood Chaimilln &n¢J truste¢ Pag¢ 9 Wolfram Syndrome UK Independent E¥aminer's Report to the trustees of Wolfram Syndrome UK I re￿r[ lo lh¢ charity truste¢s on m} examination of the acwunts ot th¢ Chgrity for thc year ended 28 February 2025. Respon51bllltle$ And bA$l$ of report As thc chariiy's tru51ee5 yoli are responsible for the preparotion of th¢ o¢¢ounts. The Lharily'S trusteeg consider that an audit is not required fnr this year under section 144 of the Charities Act 2011 I the Charities Act") and that an idependerki examination is needed. HAviny 5ati5fied mvself ihat the ¢hBrity is not subjecl (o audii under company law 4nd is eligible for independent examination, il is my resporsibility lo.. ' examine the accounts undcr scction 145 of the Chariti￿ .4cL . lo tollow (he procedures l&id domn in the genernl Dire¢rions 8ivcn by the Charity Commission (under section 145(511bl ofihe Charili¢s Acll, and • lo slalo wh¢ther p8rticu18r matters have come to my allenlion. BASIS of Independent exgmlner's Jt8t¢mellt MJ. examinatlon was Ca￿led oul in accordance with 8ener41 Dlreclions Biv¢ft by Ihe Charitv Commisslon. An ¢x8minotion includ¢s a rL'i'i¢w of thc 8¢countin8 rccor(Ls kcpt by th¢ Chority and a compari¥ort of th¢ accounts presenied ivith those records. It alsC* irtcludes consideration ol'any unusual items or disclosures in the 8c¢oun¢s. und yeekin¥ explanllLii)n% friim ihe Lruyteeg ¢()ncemin8 tsny .%uLh muiierg. The pruL'edurvs undertuken di) nol provide Jll th¢ ¢i'ideneL ihAI iv(iuld b¢ r¢quired in audii, and cons¥quenily no opinion is ¥ii'en #5 10 whether the accounts present a'lrue And fllir. vlew And the report is limitcd to thos¢ m&ttcYs sth oui in ih¢ st8t¢menl below. lttdep•ndeut exlmlner'i stitemenl In conncclion with my examination. no material matters hovc cnm¢ to my at¢¢ntion i¥hich 8iv¢s m¢ causc to b¢li¢Y¢ that in. any material respect: the accouniin8 re¢ords were not kcpt in accordance with section 130 of the Chariti￿ Acl; or . the accounts did not accord M'ith the ￿coUntIng records- or . the a¥￿unIS did n()t compl>. Ivlth ¢he applic¥hle requiremen14 Lon¢¢min8 the lom] ond Content ofdLciJunLs sel out in the Charities (Accounis and Reports) Re8ula(ions 2008 oiher than an>. Iwuirenient thllt the Acco￿nts 811'e 'truc wid fuir. vi¢iv whlch is not a matt¢r congidcrcd os port of an Ind¢p¢ndeni o¥&minMtion. I have come #cros no oiher mallers in connection with the examination to which aiteniion should dramm in this repo erto nabl¢ n proper under5tsndin8 of the accounls to be r¢Ached. Matthew l.lodson FCA Independent Exarnin¢r Wislon House I Wision Avenue Worthing Wes£ Sussex BN'147QL Datc.. Pa8¢ 10 Wolfram Syndrome UK Statement of Financial Actlvities for the Year Ended 28 February 2025 {Including Income and Expenditure Account and Statement of Total RecognRsed Gains and Lo8ses) Total 2025 Uttrestrlcted Reslri¢ted Note In¢om¥ And Endowmtnts from: DonAtions Artd l¢gaci¢s Oth¢r tradin8 activities lovestmenl incomc 9.091 38J30 9,735 1111,837 656 72J07 650 Total Incom¢ 47.6ry1 73.607 121228 Exp¢Ndllure on: Raisln8 funds Charlthble acdvliles 129,5491 127,1331 (29,549> Total Expcnditure 83,041 139.7231 Net expenditure N¢L mov¢ment in funds {9.0611 19.434) 118,495) ReeoftelllAtlon of thnds 'I'otsl funds brought forward Totsl funds Larried lunvard 131020 18 112 531 The notes on p8g¢g 14 10 26 tomi an Inleg￿ part of these financial stat¢m¢nts. Page 11 Wolfram Syndrome UK ststement of Financial Aetlvilies for the Year EDd¢d 28 F¢brnary 2025 {Ineluding Income alld Expendlture Account and Statement of Total Recognised Galns and Losses) Tot*1 2(124 iinrestricled Resrricted Note Imeom¢ and Endowments from; t)onarions and legacicy Other tradin8 activities Investsnent income 15,108 45.737 500 24,392 50,662 39,500 (y,399 500 Total Incomc 136 399 Expendltur¢ on: Raising t￿rtd9 Chori¢able llalvltleg 148.4781 (4,737 {48,4781 65,3871 Toral Expcnditure Net income I'ransfers bet1￿en fvnds 113,865 8,130 14,404 22,534 Nct mov¢ment in funds 5.630 16,904 22,534 Recon¢l]l*tlon of fitndg I'otal funds brought forwArd Total funds carrled forwBrd 31,939 76,553 108 492 18 93,457 131,026 All of the ¢harlty's &ctivili¢$ derive from eontlnulng operaLions durin8 the ob)ve Nvo periods. The funds brcaKdo¥ffi lor 2024 15 shoii'n in noic 18. The notes on pages 14 to 26 tomi an integral part of these financial statements. Pa8L 12 Wolfram Syndrome UK Balance Sheet as at 28 F¢bruary 2025 2Q25 2024 No¢¢ Flxed Asgels Tangible assets 14 241 Cuwrent *ssets Stocks Debtors Cash al bank and in hand 13 16 967 267 114 891 425 131.816 116.125 133,351 Credltom: AM•uthtg falllD% due wlthltt one year 17 Net current assets 112 31X) 1311.785 Net issets 112.531 131.026 Funds of the ebarlty: Re$trl¢ted Intom• fundi Reslrl¢led funds 84,023 9.1,457 UDmtrlet¢d Ineome fvndj Unre51ri¢l¢d fvnd5 2%.508 37,569 Total fuDdi 19 12.331 131 ()26 ¢141 statements on p8g¢s 11 10 26 iv¢rc approvcd by th¢ Irujlocs, and aulhorised for issuc on nd signcd on Iheir behalf b>.; Mr ylshenvood Chairn)an and Trus¢¢e The notes on pages 14 10 26 tornl an ini¢grnl part of these financial statements. Page 13 Wolfram Syndrome UK Notes to the Financial Statements for th¢ Year Ended 28 February 2025 I Cb4rlt)' statu$ 1'h¢ ¢harily 15 4 ch￿ilable Incorpor8ied Orgimisalion ICIOI and ¢onsequ¢n¢iy dovs r￿L huve shgre capi1￿, The address ot'its registered oftice 1$: 9 Church Way Tarrin8 Wiirthing Wesl guss¢x BN13 IHD l Aecountlng poll¢leJ Surnmary of slgnlflcant AfLOllntiag poli£leJ and k¢y a¢Lountlng ¢stlmat¢s I'he principal a¢courttin8 policies applied in the preparaiion of these tinancial statements are sel out beloiv. The3¢ poli¢i¢s hAV¢ beert consi$i¢nily #pplied lo all the years presented. unless otherwiK slal¢d, Stgtewent of Cotnpllj￿ce lThe linancial stslernLnt8 have l)een prepdred in acL()r(18nL￿. wilh AcL'iiunling and RerM?rting b) Lhariiiey.. Sthtement of Recomm¢ndeil Prnc(ice {oppli¢able io choritie5 preporing their accounts in accordonce ii'ith the FinanLial R¢portin8 Sthndard applicable in Lhe UK and RepubliL ofireland IFRS 10211 (issued in OLiober 2019) ICharlti¢s SOIiP IFRS 1021), the Financial Reporting Standard applicable in the UK aftd Republlc of Ireland IFRS 102) l￿d the Compani¢s Act 2006. B4sls of pr•p4rAtloll A&%els Mnd liahilitie8 are inilially reL'I)8ni%ed aL hi%L(>rieal cnxt i)r Ir8n4aLlinn value unlelti QLhern¥i%e 41a￿d in Lhe rele￿ant uccounlin8 poli¢)I notes. The flnanclal statemenis are pre￿red In slerling. which 58 the functlonal currency (Trf the entit)., Gtslng ton¢ern -lThe Irusl¢e8 ¢onsider thAi there are no maLerial un¢ertainties aboul the charliy's 8bilitv lo ¢wnlinue as a 80ing concern nor any si8nificanl 1¢ re￿ of uncertainly that aff￿1 the cai'ryin8 value of assets held b}, Ihe ¢hority. Intome endowment$ All income is recognised once the churity ha5 enlitlerneni to the income, il is probable thai the income ii'ill be received and the amount of the income receivable Can be measured reliably. Donotlons andlegficles D()nation.4 ure recugnisLbd ivhLn ihL' chuTlty h&1 bLcn noli IiLxi in ivriling ul'boih Ihi amount llnd ￿tIlLy￿LnI daic. In the event thot a donaiion is Subject to condition5 thRt reiiiiire o level of performance b). the charily before the charity is ￿tilled to th¢ funds, thc income is dcferrcd and not rccognised until eith¢r il)0se conditions arc fully mel or the fuifilm¢n¢ ol'th05¢ conditions 15 M,holly ivithin the control of the ¢harity wid li is probable that these condiiions will be fulfilled IA the reporting period. Pagc. 14 Wolfram Syodrome UK Notes to the Financial Statements for the Year Ended 28 February 2025 Grants recelvoble Gvants are rccognlsed w'hen thc charity has an cntitl¢mcni to thc fund5 and any conditions linkcd to th¢ 8ranE$ h&vc bccn mcl. Wherc pcrforrnance eondiiions are aLthchcd to the grant and Irc yet to bc m¢( th¢ In￿rn¢ is recognised as a liabilit). and included on the balance sheel as d¢ferr¢d income to be relcased. Inveslmeni Income Diiwidends are recognised once the dividend has been declared and nolltication h&s been receivoj ot the divldend duc. Espendlture All expenditure is recognised once there is a legal or conslru¢livc obligation to that expenditure, il 18 probable settlement is required and the amount ¢8n be measured N'liabl!". All costs are allocated lo Ihe applicabl¢ expendilur¢ h¢adin¥ thaL agbiregdle simil¥r L'u%1% Lil Ihul LaLegi)ry. Wh¢re Lii&ls' iunnoL be ¢JiTeLLI}' dtlribu*d it> particular headings they have been alloeated on a basis which is reA50nable*.jll$tifiable and consistent. RalslnKfvn4ls These 8rL Costs incurr¢d in atiractin8 voluntary In¢om¢, th¢ mgnagem￿l of inv¢51m¢nls ond those incurred in Lradin8 ac¢ii'iti¢s tli&t rais¢ fui)ds, Chorlfoble ocÈlvlile5 Charithble expenditure comprlses those costq incurred by the charlty in the deliN'¢ry ol. its activities and services for it5 bert¢ficiaries. It includes both cos1S thllt cAn be all￿¢aled direcil), lo such aclivities and those costs o(Bn Indire￿ noture necessary to SUPFQrt them. Support ¢o$ls Support costs include Lenirnl lun¢lions ond huve been allocaled to aolivily cosl cate8ories on o b8515 consislenl wiih ihe u8¢ (Il'resuurces. f(Ir ¥¥umDl¢, 411()Ldting pft)pen)' (x)4is by fliH)r are￿5, or Per ￿pIts, 4t￿￿. LX)yls by the time speni ond other ¢osls by thelr u5a8e. CJoveni*iict eoits I'hesc Include ihe costs attributobl¢ io (he charity's ¢omplianc¢ with ¢onslilutional and statutory requircmenl$, includin8 oudli, slral¢8ic management and trustees meelinbTS and reimbursed ¢xp¢nses. TAXAtlon The charity is considered to pass the lests Set out in Pont8roph I Schedule 6 of the Finonce Act 2010 and therefore it meets the definiiion of a charitabl¢ company for UK ¢orporalion tax pUrr￿eS. Aceordingly, the charity is rA)t¢nti&lly ex¢mpi from taxalion in respect of income or capithl gains received ivithin caie8ories covcr¢d bv Chaplcr 3 Part I l of the Corporation Tax Aci 2010 or S¢¢tion 256 of the 1 axation of Chargeable Gain5 Act1992. to the extent that such in¢ome or gains are applied exclusively to charitable pyrwjses. TAnglble fixed *sJets Individual lix¢d assets are initially recorded at ¢osl less any subsequent accumulated depreciation and subsequent ftccumulated imp&irn)ent losses. Depre¢lMtlon and 8mortls8tlon D¢pr¢¥'i*iion is provided on lungibl¢ fixed #SS¢L5 wriie off th¢ Lost orvaluation, k￿Y esiimaled residual valu¢, over their expected uselul economic lile as lollows.. Pa8L. 15 Wolfram Syndrome UK Notes to tbe Financial Statements for the Year Ended 28 February 2025 A$g¢t cl￿9 Plant &nd m%hinery ()tTi¢¢ ¢quipment Dtpreclatlou method and rat¢ over 4 year5 beiween 2 and 5 years lJnp¥lrment of fixed *55tts A rei'iei¥ for indi¢ators of impdimienl is ctwried out ot eo¢h repctrting date, ii'iih the recoiicrable amount being estimated ivhere 8uch indiclllors exiqi. Where the carylng i'alue ¢x¢eeds the recoverable amouni, the asset is imptslred fjccordingly. Prior impairnienls are also revielved for possible reveTsal al e&ch reportin8 date. Research and development Re8earch and d¢i'elopmenl ¢xpendilure is WTillen orras incurr¢d. Stock Stock is i'ulu¢d at the low¢r of cust and estimated selling price less costs w (omplctc nnd sell, after du¢ r¢wd for obsolele and slow movin8 siocks. Cost ig detemirted usin8 the firsl.in, flrstvout (FIFO). Cash and fA5b equlvilenty Cosh and ¢osh equivalents comprise Losh on hand und CDII dep0511s, and other short-tsmi hi8hly liquid in%'¢8Lmeni% ihai 4re readily ci)ni'e¢1ihle Ii) u kni)wn amtsunl ol'La8h bnd or¢ %ubie¢i an insl8nificanL risk ()r han8¢ in value. Trnd¢ credltorj Trade crcditors arc obli8alions to pay for goods or servicey thal hal'c becn acquir¢d in the ordinary ¢our5¢ of busine35 from suppliers. Accounts poyable are classilied as current liabilities if the charity doe5 not hai'e an uncondition41 right, at the ¥i)d ol'the reportin8 period, lo defer s¢ttl¢ment of the credits)r for ai least tw¢lve mi)nihs diicr Lhe repi)rtin8 d&ie. Ir lh¢￿ is Jn unuindilii)nul ri¥hL L¢1 defer setilemeni Ibr 01 leas1 Livelve mnnLhi otter the reportln8 date, the) twe presented os non-¢urrenT liabilities. Trade ¢redil0¢s ar¢ r¢¢ogni$ed ini118i1}' at the transaction pric¢ And $ub5¢qu¢ntly m¢&sured at omortls¢d ¢osl using the eff¢clive inler¢st method. Fund $lructure l1nreslric￿d inci)me fund$ 8rL 8Lneral funds Ihal av¥ilublE Inr u8e al the Iwstees di.%Lre¢ii)n in furtherdnce nr the objectlVLS Ot the chariry De51¥nuÉed funds are unreslri¥l¢J fund5 eamark¢d by the Irus(ee5 for partiLular fuLur¢ proj¢¢l or ￿mMItMent. R¢slricted income fund5 are those donaled for us¢ in a poruLular Mrea or for spe¢ifi¢ purposes, Ihe ust ofwhich is restricted to th&t ar¢ll or purpose, Fln#nclal Instruments CIu551flcftrton lThe charity only bas financidl a55¢15 and liabilLies of a kind that qualifv a5 b&sic fin. Allocated suppon costs 3,168 b) Colts oftradlng a¢tlvkl*s ULregtrl¢led fundg G¢n¢r&l Total 202S Total 2024 Nol¢ Co8L8 of g(>ods sold Depre¢lailon, 4mort15lltion and oih¢r similai. osts (lther direcl ci)sLs ol'acLiviLies lor 8eneralin8 funds 383 383 289 140 140 36,833 21.992 21,992 37,303 Pag¢. 18 Wolfram Syndrome UK Notes to the Financial Statements for the Year Ended 28 February 2025 7 Expendlt¥re on cbaritsble *¢tivities Unrestrlcted funds GenerAI Restrlet¢d funds TOIRI 2025 Total 2024 No¢¢ Wolfram Syndrome Research Support for WS community Conlerencc costs 233 16,895 17.128 22,147 60,135 5.991 82,302 5,991 6U,Y51 1133) 4.5fi9 (invvrnance Cn8L8 83.041 110 174 Pago 19 Wolfram Syndrome UK Notes to tbe Finan¢lal Statements for tbe Year Ended 28 February 2025 8 Analy$15 of Eovtrthinte an4J support tosts Rablue funds ¢xp¢ndltsre Support co$ts Alloeaied to rnlslng fundj Admln15trAtIo Costs Total 21125 Total 2024 c￿St& of 8¥neralins dvnulioi)% and legacies 7,557 Cov•rnAnce ¢oJts Unre$trlci¢d funds GeD¢rMI Totnl 2025 Total 2024 Indep¢ndent exAminLr fees F.xamin8tlnn ol'the tinancial statemenis PN)fcs4ional fccs Oiher Bovemance cos¢5 1,428 13 1,428 13 3.312 1,344 13 4.753 4.753 4,569 9 Net lrtcomlnWoutgoln8 reJour¢ei Nei lout8oingyincomln8 re5our¢¢5 for lh¢ y¢gr include,. 2025 21124 D¢pir¥iaLlun or rixed assets 140 10 Trust¢es remuneration ind eip¢n$es Durlng the year the Chorii), made th¢ following tran5DCtions with irustccg.. Mr P Lynch £1,580 (2024: £Nill of expffises wer¢ r¢imburs¢d io Mr P Lynch durin8 the yeAr. Wolfram Syndrome UK Notes to the FinancAal Statements for the Year Ended 28 February 2025 I I StAff ¢osts 'rhe uggreg&ie payroll cosls were as follows.. 2024 Stiff costs durlng the year were: Wage5 and salories Pension ¢05ts 78,217 66,785 68.789 The monthly average number of person5 lincludin8 senior managemeni I leadershlp te&m} employed the chorit), durin8 the )'eor cxpressed as full time equivalents M'as as folloii's.. 2025 2024 No rull Ilme employ¢¢s Conlribulions to the ¢mplo)'¢L pension ￿heM￿ for the year tolalled £2.34712024- £2,004). No ¢mploy¢¢ rK¢ived emolum¢nt5 of mor¢ Ihan £60,000 durin8 the year. 12 Independent exarnlner'g remuntr*tlon 21125 21124 Othtr fees to examlners The cxamlninB of the accounls of tho charSt>' Pa8e 21 Wolfram Syndrome UK Notes to th¢ Financlal StatemeDts for the Year Ended 28 Februar) 2025 13 T8xatlon The charily Is r4 regisiered ch8rily and is therefore exempt from I￿atrOn. 14 Tangiblt fixed 4$sets Furttlture and equlpment TotAI Cost Ai l March 2024 Additions 4.732 4.732 130 At 28 FebrbJAry 2025 DepreelAtIo Ai l March 2024 Lharge for the >'¢8r 4,862 4.86? 4.491 4.491 14 Ai 28 Febwjry 2023 4,631 4.631 Nèt book YAlue At 28 Trebru￿, 2025 2Jl 231 At 29 february 2024 15 Stoek 2025 1024 Sts)Lk 967 425 16 Debtors 21125 2024 Tradc dcbtors Pr¢payments 866 244 267 367 lJagL. 22 Wolfram Syndrome UK Notes to the FRnancial Statements for the Year Ended 28 February 2025 17 Credltors: amounts falllng due wltbln one ye*r 2015 2024 Trude Lrediiors Other taxBtion and social sccurfty AcGiwals 1,620 546 41 18 Funds Balance at I M4rch 2024 In¢omlDg resourtes Re8ourees expended Bolan¢¢ at 28 February 2025 UDre5trl¢ted fvnds Gcnort71 General Funds 32.569 47,622 156,683) 23.508 D•lxnttlefl Research Fund Total UDr¢yirleted fundj 37.569 156.683 28.508 Restrlcted fu￿d5 Wollinm Svndnime Conl¢r¢n¢¢ Rcs¢ar¢h Fund tjcll N5 IS Contract TREATWolfram 6,006 34.488 42,869 10.094 15,991) 116,894) 16U,156) IJ 18,894 55,11211 10,094 1,300 72,3117 Totsl reitrl¢ted funds 93.457 73.607 183.0411 Total fundj 131026 139724 112 531 P4gc 23 Wolfram Syndrome UK Notes to the Financial Statements for the Year Ended 28 F¢bruary 2025 Bolance at 29 February 2024 BalHDce at I M•r¢h 2023 Jneosnlng resources Resources expended Transfers Unrtstrlcttd fundg Generul General Funds 26.939 6J J45 (53,215) 12,5001 32.569 ￿￿1¥nated Research Fund 5,000 TotAI unrestrleted ￿Ld9 31,939 53 15 37.569 Kt5trlet¢d W()Ilrum 8yndwme Conferenca R¢scar¢h Fund Breaking Do￿ll Barriers -I'hc Nalional Lottcry C()mmunity Fund. r.WB Albert Hunt Trust BCFI h'lls Contract International Symposlum TREATW(Ilfrum 116 (2318) (1081 6,(K)6 34,488 2U,491 108 16215 3,584 496 33.672 2,219 (3,584) {496) (41,4051 112,896) 50,662 8,177 42,869 Totsl regtrlcted funds 76,554 75,054 160651 2.5(Kl 93,457 Tot•1 lunds 108493 113866 131026 Wolfram Syndrome UK Notes to the Financial Statements for the Year Ended 28 February 2025 Ibe specific purposes for which the funds are lo be applied ar¢ as follows: W()Ifr4m Syndrome ConferL'nL* Income and c05t5 towards the annual conferen¢es. Research Fund- FuM(ts rais¢d. dortalcd or dc518nal￿ by MISUK io assist in rc3¢8rch of the syndrorne. Breaking DoiN7J Barriers BDB (rranl from S)'Ivia Aduni8 Trus1 foi. BAME families proj￿1 lyeor l). Fif)FJ Year 2.. A second Bl)B 8ranl from Sylvia Adonis Trust lor a project with Ihe WS eomrnunity Across iffereni culiuTe5. 1he Nation41 Lott¢ry Community fund (INLcfi - Aivards for All.. Carers W¢llbelng Pllot Project fgr WS Carers. The Nuli(Inul Lattery Communi(>' Fund (TNLCFI - Awurils For All.. EmiitionAI wellbein￿ ProjeL't for WS atTeeted lldult5. Alb¢n I lunt Trust for support ofws affected &duli5, BCH NHS conti￿l- PmvisioTr of WS r¢laled support services to Birniin8ham Childten's Hospital. International Symposium - Funds recelved towards the cost of holdin8 an inlemational researchers svmwslum. I.￿ATWo1tr8rn - funds r&is¢d, donated or d¢si8n&led by WSUK to assirt fgmilie￿IOdIViduals in coverin8 any trnvella¢comrnodalion Costs that are incurred by th¢m for takin8 paTI in the 3 y¢ar TRLATWolfram clinical trial M,hich slartcd reeruitmenl in January 2019. wilh regular i'isits io Blmiin8hal￿ L'hildren'5 Flospltal & Queen Elith.th H(iypilul Birniin¥hym. P48c ?3 Wolfram Syndrome UK Notes to the Financlal Statements for the Year Ended 28 February 2025 19 Anily$is of net aggets belween funds iIDre$trleted funds Genernl Tot81 At 28 Trebruary 2025 Restrl¢ted funds Tan8itr)Ic fix¢d assrt Current &ssets Current liabilities 231 32.102 231 116,125 13 8251 84.023 Tolal net assets 28,508 112 $31 Unre$trl¢¢ed fund$ GeutrAI Total ￿ndS At 29 FebruAry 2024 Restrlc¢ed fund$ Tan8ible lix¢d assets Lurr¢nl a3sels Lurrent liabilities 241 39,893 241 133,351 93.458 Tolal nel tt55els 9J,4511 131026 20 Analy51s of n¢t fuDdJ At28 Febr￿ArY 2015 AI I 2024 Cash at bank and in hand 131816 131816 13181 131816 21 Relxted party trAnsa¢tlons Durin8 the year th¢ chority mad¢ the folloivin8 reloted party li￿S&¢I10ns, Traey Lynoh (Relatcd party of Trust¢¢ Poul Lyn¢h) Cjross wA8es £18.404 12024.. £17.353). Ai Ihe b4lanc¢ lheel ¢J8ie the amount due lo/irom Tracy LynLh £Nil12024- £Nil). Clng Ishernood IRelaied party of Tjustee John IsheThvood} Gross waBes £21,49912024: £20.134). At the balance sheet date the amount du¢ tollrom Gina Ish¢n¥ood iy £Nil12024. £Nil).