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2024-04-30-accounts

RF.GISTfr.RED COMPANY NIJMBb.R: 08031174 Rb.lJlSTLRF.D CHARITY NUMBL.R.. 1147658 UIYGAL INFECTION TRUST REPORT Al￿ ACCOUNTS 30 APRIL 2024

FUNGAL KNFEcfioN TRUST INDEX P*ge Referojce and administrntive details Independent &xaminer's retM)n Statemellt of fllmnciat activities 10 Ba]an¢e Sheet Notes to the accounts 16 ApEfTKIix Scientific publi(ztions and presentations

Trllstees Professor P J FolkmaD Mr P G Oxnam Mr J C Morgan Dt C P9￿u[sI Professor R Hay Hon Secretary Mr J C Morgan Bankers Royal Bank of Scot]and Macclesfield Chestergate Branch l Hardman Boulevard Manchester M3 3AQ Indepelldent Ex2miuer Roslyn B¢attie CoEnpany Solutions Limited 2 Festi*al Sqlwe Little Gennany Bradford BDI 5BD Registered Addre&8 20 Elsdon Place SL Georees Wood Notthumbcrlalld NE612GY Charity RegistTation: 1147658 CoM￿nY Registration: 080J1174

FUNGAL INFECTION TRUST TRUSTEES. REPORT The IM)ard of Trustee5. who are alsodirectOT5 of the (Tharitr forthe purrK)ses of the Cornpanies Act 2006, present their rcport and financial staiemcnts of Fun8ai Infeetion Trust for the N'ear ended 30 April 2024. The flnancial statements hai'e preprcd in 2ceordan¢t I￿b the atu)unting wJli¢iL8 as set out on page I l aDd cotnply I￿7th the ch2ritv's Irust dee(I the Ctsmpallies Act 2(K)6 and the State￿ent of RecollJmen(kd Practice- Accounting and Reporting b). C'harities 2011. STRUCTURE GOVERNANCE AND MAP4AGEMENr The Ftjngai Infection Trust l-The Charit)." or"The Trust-or-Ffpi is a tomwiy litniied by guarantee and governed bv its Memordndum and Articles of A&￿￿1￿10n. DIRECTORS APID TRUSTEES I'he dir¢ctOT5 of the charitable wrNpanY #re its TTUStee5 for the of chartty law and throughout this retxkrt are collectiNclv rcfcrred to &5 Éhe Trnstees. The Trustee5 Serving duriTrg the year Fere follows: MrPGO%na Cbirmx Mr J C Morga Profe&sor P J Folkma Professor R Hxy Dr C L Pankhurst New'frustees are iThtervteM'ed and appTriTrted b) the existing Trustee5. Risk Mallag¢￿ent The Trustees have examined the major stratrgic. busin&Ks and Omional risks which the ¢haritv faces and ¢onfimi that SN'Stems have been established to enable regularrerrtwtsto be [￿odUCed so that the neces5aTr stq)s can be taken to lessen these risks. orgxnlsatiots￿ Stryctsrt xDd c￿ern#￿te The Trust is managed by the Trustrek The Trust has no paid or Troluntar) etnploNtts. Acc(yunts are prepared b!. the SecretarN' on a regular b&sis and presented to the Tnjstees at their meetirtgs. The firtancia] of the Trusi is rei'ieis'ed by a Trustee sutr￿ComMIttee prior to each Tn]ste¢s" meeting and tts recommendations pr¢sent¢d to the meeting. A minimum olthree Tnjstees meetitigs are heid each )tar. Responsibilities of Trusttts Law applicable to chariiic5 kn England & Wales requires the TnJsLeesto rw fjnancial ststements foreach financial year il'hich giN'c a truc and fair Tr'ieii. of the incoming r￿urCeS and appli&qtion of thc resources of the charity during the )'ear and ot.its St*e of affairs & the end of the )rar. ID preparin8 fuwicial statements o js'in8 a truc and fair Tr'iew. the Tru5ttts recogni5e thei. Should follow best rnice and: select suitable accoutrtÈng w)licies and then appl). them consiAentl>'- mdke judgements and esiimales thal arc reasonable and pruden stste w'hether applicable a¢¢ouniing ststsdards aJLd s￿lements ofiecornlnended practice ha￿e ￿ell followe(L' Pre[￿re the financial statements on the going concern FA8is unles5 it is inappropriate to presume that the charity ￿7]1 continue Èn opcration. Tht Tnjstees are rcstx>nsible for keeping proFtr accounting records ivhich disclose ￿'&th re&8onable accurdcy the financial position ofthe ¢harity andM'hi¢h enable theTn to as¢ertain its financial ￿$ll￿ona￿dI0¢n%Ure that the finantia] slateni¢nts compl} Mith the r￿M￿leS A￿ 2006 and the Sta￿meth of Recommended PracLice - Accounting and Rep)rting b>. Charitie5 2005 and the TruA Dee(L They are a150 rwn5ibl¢ for safeguarding the awts of the charity and hence for taking rtr&sonable step5 for the prei'eniion and detection olfiaud 2nd other irrcgulariiics.

FUNGAL INFEcfioN TRUST TRUSTEES, REPORT OBJECTIVES APID ACTIVITIES T() rwomote research in all asFcts of rnvcolog!.. MI'C￿1¢ di5easffj fun801 toxicology and microbial disease lof all lii'ing things) and to wblish the useful rEsults thereof. 2. 1.0 adl'ance education particularl!. among phN5icians and s¢t￿tiSts al￿t mycologj.: mycotic diseases. fungal toxicology and microbial diseases in gencrai. 3. To generally support basic research into fiEngi and fullgal disease, train scienli5ts in mycology and related di5cipline5. 4. To provide infornialith) to parients suffering from f￿ngal diseases. in ]Mrticular asttrqllosi& S. To raise aM2rene&s of fungal ￿thOge￿S and fungal diseases amongst the general publi¢ in the UK and intern8tionaJly. Revitw of Attivitits R¢vxw of Activits Ti]e FIT web5it¢ Iili%Tri.tun￿lithl￿l1EiJ17IIlls[.I)TrT) re(wthd a slight fall in traffic fioln about 660 visitors per tnonth in 2022 to earl). 2023. to an average of46) unique visiior% per Tnonth in ?023-mi4 2024. The most popular pages after th¢ home page are 8kiJL hairand nail infection. Research 8ranty What ￿"t Lk). andthe linksto the Aspeigillus Website. and Microfungi. The rise of.fake neils and other online wicuMed sour¢cs Incr￿Se5 the %2lue of the trusted Frrs authoritative fungal disease online resourees. Online education in fun micro￿P￿. and histolo The FIT supports the world's fjrst online Microscop). and El1th1o￿. course. To (tste this ¢our5e has hosted neari)" 5.000 distill¢t u￿rs from ￿er l)0 countrie& a 61% incrcase in user5 over the year 2022-2023. Thi5 can bt attribllteLI to the tar8Ctcd marketing ha5 taken plac£ to promo the r￿11. urx]ated tesvwce5 in Modules 2 and 3. Translation of the resource u]xlates kn'ere completed fi)r Fr¢noh: Spanish, at￿ Pmuguese. with Chinese in progress. In 202J alone. atmosi 5.1K)O Indi￿.1(￿1a7 sessions M'ere recorded on ihe platforni. microfi￿gr has a gloEd rrdch. With oier 110 dIffe￿rtt CO￿trIeS rq)rescntc(L The Tnain audiencts are in the table. 'I'hose registered on the Course Can r¢-en(er the ww5e at anv time to ￿fresh their knowledge. This Tnakes Tnicrofimgi an ini'a]uabl¢ life-l¢)ng leaming twl for all healthcare practitioner5. TheAs -Ilu8 Website c￿Try Usen% 1325 424 -ItkJ The Asp¢rgillus Website celebrated its 25 Year in 202). The Asr£rgillus Website is the i¥orld"s most comprehensive res0￿ ihe pathogenic and allergenic fungi Asperoillus and all the diseases this group of fungi ￿ll$e_ It is completely fr¢e to a]1 uKr& The Aswgillu5 Website 15 Sttll rrad verv ￿7￿¢1! acros5 thc wortLt It has alx)ut 6.500 uniquc Trisitors mortthl}". ivhich is a slighi fall froTn wevious Yl￿ but this usage d(ts [￿t record all the users of the drug int¢wtion datab￿. The AS￿rgi1]uS Websiie wovides free ￿Y ac¢ess ¢0 >74.(XX) over 16,21K) scitntific articles (including a unique collcction 01 8J6 histori¢al articles) and over 17.320 conftrenct abstra¢¢s 1974 On￿th. The A%TKrgillus Il'ebsite hoAs a ¢Limpr¢h¢rLSiif list of drug-dTug int¢Tactions antifimgals th,hi¢h 15 continuall updatcd. This drng intern¢tion datab￿ iiiiiii.asrLriTIIIu%.Iiriy -InliraLITcins1 (including the antifvngal drug interaction app for anitroid phones} is twular atid Mtll used. The datab￿ &8 of Ma), 2023 hi)sted inter2Ctions bctiveen 1628 liceD5ed ¢bug5 and 13 sl'strmtc aniifungal agents (a total of 21,164 tx)5szble inieractionsl. In 2023. 50 n•i'ly registered drugs iirre a<l(kd into the datab￿. iiith neil. entries ]Enetting the interaction5 that exist wilh the antifun8al a8ents. In addition i2 entri￿ W¢TE Ut*Jatcd new infomation. The new antifungal ibre%afungerp added. The supp)rt sotlwaE was a]so upjated to wovide 8reattt thilit).. A majtt review p￿r w&s pub]i$hed in Awil 2024, that had at its Core data from the Antift]nga] Drug Inieraction database15ee below). 380 89 47 45 37 30 29 70 IAalay 26

FUNGAL INFEcfIoN TRUST TRUSTEES, REPORT Joumal of Antimicrobial Chemotherapy J Anrifflicrob Chemochoy httpsjldos.orgll0.1093fl￿10kQel03 Triazole antifungal drug interactions practical considerations for excellent prescribing Russell Lewis C . Saoroh Niaz￿AlE..￿ , A[￿reW Mclvoè. Souha S. Kanj . Johan Maertens . Matteo Bassettl . tborah levi￿ . Andreas H. Groll u and Dtjvid W. Denning Tub l. TotdityofonlthJwl rter(￿l[￿]S￿￿esOnL[Qt[E¥￿t0￿￿Éity I￿rrI￿￿￿OI￿rnId￿￿l￿ thègNaicomknnationnthÈ AMPA$￿ AmrthB Arith P0 C05PD 22 23 133 133 120 122 1353 1350 vl￿ oiese Ilxexo TÉYtswfme 49 57 i£0 173 141 21S 181 194 92 79 223 163 189 1484 1359 1133 1109 1124 1072 118 212 den)te li 82 92 1539 IS25 15 96 1516 15 1610 1627 In a t￿lea[ quarter. there are 7(M) users of the aniifungl in￿raCtIOnS Iitbsite: mollnew users. The greatest number of Lwrs are from the UL USA. Chin4 C8nad& thrtnan)". A￿lIa and Brazil. l.eadin Internati(Trna] al F.du¢atitsn Education of healthGve professionals is a kel. need to ]M￿￿"e diagnosis and thernpj. The l.IFF. ￿ebSIte has been 0￿rating srnce 2012 the obj￿11"e of prm'idints edu¢ton (M this highly spe¢ialÈsed TOPI¢ for ¢linieians .Likl. Th¢ F.ngli5h language kersion 15 rthiTrantlN N'seii'ed fTorD IJSA, InLfi& Ilk, Nigeri4 Philipptnes Canad& with China failing the top 10 countrie& There has been substantial 8roMth of usage from SEAsia MithoN'er42.0(M) users (a >50￿/0 rise). The wljole l.IFE website is a150 ai'ailable in Spantsh. over 5:5(K) iJs¢rs from Mexico. Spain, Col¢)mbi4 US& P¢ru and Argentin& The most p)wlar rAges otj the b.ngJish trsion are the fungal culture. mi¢ros¢opy. ¢lini¢a] gJideline& otomy¢osis. tin histopathologi. fungus bajl of the sinu5e5 and C￿MIlda 5pp. different fro￿ the pre&ious year. On the Spanish i'erstott, the most wlar pges are fungi, otom}'c05is. tinea irnbriLX fungal cdu¢ation. Canthd@ TrichoplD¥on: Beta l.) 8]Uea￿ jobs and career% Aspe￿1111￿ Rkndt%or￿l(l again different fr(￿￿ the previous year. LIFE'S YouTulx dwinel was setup it) 2017 and has 4,700 suiwkni 42.089 UnitÈdSlatos 671 2.938 Ni9¢riè p￿11￿￿￿% l.C77 946 Jl to be 2 very imrKYt3nt comFrt)nent ofthe LIFE WoAdiiide ethjcattonal offerin8. Ithosts I I I videos i¥hich hal'e iNatched >517,(KK) times￿1th 95.OIM) vieThs in the lasi Tr'var. There is still Mides]xead interest in the antifimgai medieauon I video& but there has a surge in interest in tinea ¢apilÈs and our featsuyd skin incision video& 733 donesr 725 10 Pth5lan 724

FUNGAL INFECTION TRUST TRUSTEES, REPORT PPFE Antifungals Antifungals Antifungals 'Fluconazole Itraconazole Voriconazole 7Tr.55 rmatophytes Cryptococcus Invasive ', PFE Antifungals Tinea capitis Pathogenesis Amphotericin B t3Kvth+SytZS Cryptococcus Cryptococcus PIFE Candida Antifungals Breastfeeding & pregnancy Antifungal managem Diagnosis 1￿7 caftdi(fia' , 136 an￿[u￿? IIKThB+6)tJrnb)I 8tKv.￿- rmatophytes Candida MALDI-TOF Galactomannan ideDtificatiqa w: . £Platelial Tinea capitis Id¥ LIFL manages a separate Nirteraccount ilhieh haswwn its folloiNersoi'erthe tasi Nearby I￿/0 to-16(K). Although Ive hai'e continued to use i)ur Tivitt¢r d￿the1 as È methTrJ of wmmunitation. 2023-24 ha5 seen a re21 <trop off i s¢itniitic Inte￿51 M the platforni. There are n(iceabl!' f￿￿rr m)cOlo￿ colleagues. and scientists in general, usin this platform due to the increased t￿litiCISation and rise in advertising on Tii'iuer Call￿ X). Our en84ement rigures are much red￿ed Mhen Compared to 2022-23. In 2022-2J rtteived oi'er I Iok impressions but in 2023-24 this fa]len to iok. For 2024-25 LIFTr. will f(tus cxploring so¢iai ]ncdia pIaff<Th￿ to access our audience. Burden of fu al dis&q5e CStimes A component ofthe I,IFTr. etTort ha5 Fttnto a￿￿ette$S0r fiLn8al infections generally. byquantrfjryngthe problem better. This has involved estimating the burden of serious fun8a] dise￿ in oi'er 100 tvuntric5, to higlllight the seriousness of a range of primap" 8nd serondan" fitngal di5e&ses. Re[￿e￿IMationS for Ilgand*w2s published in the l&< i"ear. Addittons since last S'¢<W'S rq￿rt are underlined. Published in journals (x87): AlgeTi& Ar8ellti￿ Austri4 knrtwjan. Bangladesh. Be[￿UM. Brazil, Burkina Faso, Cam¢roon, Carod& CaribiKan Chile: thin4 Colombi4 Congo (Republic OD. Cote d'IN'oire, Czech Republic, DeTno¢rntic Republic of L'on80 (DRC").. Del￿n￿ [k)fftiTrI(￿ Republic. Ecuador. b.gypL F.ritre4 b.Ihi(Ipi& France: Germanj". Ghan& Grttce. G￿￿emaI4 Flondw4 IluDgaTi. Indi& Enthnesi& Irdn, Irelan￿ 18rael, lthl). JaTnaic4 Jordall. Kaz2khsw Ktn%'4 KU￿21￿ K}W.zst￿ Maiaiii: MalaJsi4 Mali, Mexico, Morcr¢o, MozaTnbique. Namibi& Neyal. Netherland& Nigeri4 NoTh¥7)': Oman. Pak"istan. P Peru, Philippines,

FUNGAL INFEcfioN TRUST TRUSTEES, REPORT Portugal, Qdtar, Rorn8nt4 Russi4 Senega]. Serbi< Sierra LeoDC: South Afric& Spain, sri Lanka, 8udan. %￿rden, Taiwa￿ Tajikistan, Tatwnii Thailan£L Togo. '] nnidad and TotAgo. Tunisi4 Turk¢)', 11 anda lurmtstedl, U Ukraine, llnited Arab F.rnirate5 Urugua). U26ekiw Vielnam and 7.imbabNE. Published burden pa￿T5 are Presented in abstractI￿ster form at conferences but not J'ct published (x13}: AUs￿all￿ Belarus, Benin, Iraq, Sapan. MadagaKar. Mongolia. NeM' /.ealarf Pardgua). Saudi Ay3bi4 Singap)Tt. Venezuel< Zarnbia (detail is aNzilable on the LlI-'E ii'ebsite in the neil's section liiip.- iiil ii.lIlL-IliirlJiiiJL.i)ri' Thc FIT atso sup]x)rted seieral am￿rIant research publications and TeN'ieM's (see Appendix 11. There M'ere 10 ￿tr. reN'iei¥ed publicatLi)nS Lll calendar!rar2023 con54uentto FIT 8rdntsandcollatK>ratio#s. The A￿able vu4>Uts include: A comprehensive review ofinvasive aS￿gO]ll05lSttfter kidne). traTh$p1antati(￿. An overview of histopl&sma in the maj(Y souree of hisioplasmosi& with manv gaps in knowledge. A syste2mtic revieiy of the treatsnent outcome5 of mucorn!'cosi4 finding that surger). is critical, and that both tM)sa¢onazole and isavuconazole alone are partiaili. successfu], but the ¢ornbinaiion of one of them, ￿1th 8￿phot¢￿GiTr or immediately after arnphotrricin produces much Irttcr outcotne5. During the year SUPFQrt was giN'en to research wojecrs at the UnÉ%rTSitY of Manc7Kder. the unl￿£r57￿. of Ghana and Semmel%iEiS Universitv, BUth￿L Ilungan... TryaNtl and LiNin8 AlloMwJce for attendgnee and presentallOD at s¢ientifi¢ conferences are partofthe TTr￿"S rrt)lic} to suprM)rt scicntists it) the earlv s¢ages of their¢areths in mycology. A fund h&s been established in memors. ofthe TTUSt'5 f(rtller Cha]nna￿ the latr Professor Geoff Scott. The Geoff Scott Travel and Stholarship Fwid. A donation (o thi5 Fund i￿received fri)mthe Infection Medical C".hambers Parmership. Grants M'ere aiTrarded from this fund to researche￿ from India. (ireece and The c7.ech Repllblicto attend the Advattces Against A5pergi1105j5 and Ml'cology confereEKe in ￿lar& lthj)". IVh• be￿erIted from the T￿￿.$ Artivitses. Researchers iti the studv of fungi (m}colo￿).. respiratm. medicine and infectious diseases r]¥)m all over the Mwld Medical doctor4 especially thmugh the Drug Interadions datslm Patients and their ¢arers. Stlldents of medicine. phamia¢v. bits1￿. and microbiolo￿. The publi¢- sch￿1 chil¢fren. their teache￿ and tmrents. How do the Trust's Artivities Bthefjt tht Public. A￿aTeNe$S of fungal disease remains low among the genera] public. The FIT i¥ebsite enables the public to acccss reliable informaiion quicki} on this topic. auwted b) the MO￿ s￿¢1?11$td I￿tb resources at LIFL-WorlthTride and the A5pergillus Website. The FIT websiie also rt-tK)sts press aE]d general 5torie5 and explanatory articles for e85%" acce&8 for au. Future P￿lJ$ In 202￿5, translations of the Microfimgi educauoJJa] i¥elxsite into Chinese will be complctr& F.fforts to promote the FIT online education and professiona] suNN)rt r¢source5 continue at major conferences tn F.urope, USA, Asia and Afric4 ￿la onlinc talk& distribulion of br(Khure5 and dirttt conthci KNith hea]th¢aff rKactitioners. The .4swgillus lehsite and the drug intewtion ￿rtaI iiill contÈnue to I￿ up1ated M"eekl)'. Several IIK-IM5ed public engagement events are planned. Tbe FIT ii'tll reswnd to gratsi requests &$ i¢ has done preN'iously. FINANCIAL REVIEW. The results for the ￿riOd are sei OUL on tAge 9. There a swplus ollncome over ExFThditure for the year of £224120?3 £{23,(K>8)). CoTFmQ tiovcrnavKe eX￿ndItUre represented 6.84Y*l of total income {2023 10.48Yol. During the Jear grants and donations to supwrt the Ayrgillus and I.ITrF. ￿'ebsiteS ivere receii'ed from the charity. Advance Against A5p¢rgi1105is and the pharma￿Uti￿ comJ%tnies pfiztr, Gilea(L 8hionogi and Mundipham Investmtht Polity The Trustees do not ¢onsider il)ev have suffieielrt free resmt5 to invest 5UTplus fi]nds for ajjy mcdiurn to long teryn. CoDsequ¢ntly.. fund5 are maintai￿d in a bank dewisiE account

FLryGAL LNFECTION TRUST TRLSTEES, REPORT Reservts Policy The ch2rity haTre established a policy to maintain unrestricted fi]nds noicommitted or invested in fixed ￿Sets i.e. 'free reserves, at a level of bet￿.Cen one and tsTro vears ofullrestricted ewnditure. This prnvides sufficient leve]s of funds to be able to colllinue tbe current activities ofthe charitv and to pn>vide sufficient time to consider and replaee existing funding sources should there be a Si￿1]fi(￿￿ chatwe in present fi￿dI￿g aTrantsements. The reserves policy is reviewed anlluklly. Secretariat Thc Irusrees wrysh to &N)re5s ther aFpreciation of the ii'oTk undertaken by Mr J Morgan in nmning the s¢cretariat and administrative fi]nctions of the TTUSt during the past vear. IndepeDdent Examitter tn a¢¢ordan¢e the TTU5t Deeii a WOFosal to re-appoint C.ompally Solutions Limited for the forthcoming year will be put tts the.￿￿erteral meettDg. On be]Hlf of the Trustees Phillip ()xnatn 3 September 2024

FUNGAL INFECTION TRUST INDEPF.￿DE￿T EXAMINER'S REPORT TO THE TRUSTEES OF FUNGAL INFECTION TRUST I report to the Trustees on my examination of the financial statetnents of Fungal InfcctioD Trust (the charity) for the year ended 30 April 2024. Responsibilitie5 and b45is of report As the Trustees of th¢ chariiy (and a]so its dIreCti￿S forthe purposes of company law) you arc responsil)le for the prepardtion of the ftswi¢ia] ststements in accord￿ with tbe requirernents of the Companies Act 2006 (the 2006 Act). llavin￿ satisfied myself that the financial statements of the charilv are not required io be audited under Part 16 of the 2006 Act and are ell￿ble for independ¢nt examination, I report ID r¢s￿of my examin￿0￿ of the c]wity's fJnaD¢ial 5tatetnents carried out uttder section 145 of the Clwities Act 2011 (the 2011 Act). In carrying out my eXatn[n￿9￿ I have followed all the applicable Ditr£tions given by the Ch&ity COM￿15510￿ under section 145(5Xb) of tbe 2011 ACL IDd¢pendent examiner's statement I have completed Tny examination. I confirni that no matt¢rs have come to my attention rn connection with the ¢xaminaTion giving tne eause to believe that in any Tnaterial respect= accounting record5 were not kept in respertofthe charity as required by sectKon 386 ofthe 2006 Act., or the financial statements do not accord those records.. or the financial statements do not comply with the accounting requirements of section 396 ofthe 2006 Art other than any requirement that the accounts give a true and fair view which is nota matter considered as part ofthe independent exaTnination- or the financial statements have not been prepared in accordance with the methods and principles of the Statement of Recomrnended Practice foraccounting and reporttng by charities applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and the Republic of Ireland {FRS 102). I hav¢ no Concerns and have come across Do oth¢r matters in coT]nection with the examination to which attention should drawn in this report in order to eTJable a properuDder5¢aDding of the financial ststements to be reached. Roslyn Bea Bk..FCA CoJnpaDy Solutions Limited Date 41f 2024

FUNGAL INFEcfioN TRUST STATEMLNT OF FINANCiAL AcfivITIES PEIUOD ENDED 30 APRIL 2024 Total futtds Year to 30 Apri 2024 Total funds Y¢ar to Unr¢51rn* Ik5ignated fujt nds 2024 2023 Note 2024 INCOMINC RESOURCFS Ineoming resourees from genernted funds Voluntary income." Donations aDd grants Activities for geDerating funds.. Investment income Infoming resources from charitsbk actÉvities Donations and wts 9.691 9,691 44,533 1,493 1,493 867 40,5 60.258 100,758 29,000 TOTAL INCOMIL¥G RESOURCES 51.684 60.258 111,942 74,400 RESOURCES EXPENDED Costs of tbaritable aetivities Charitable &tivities 23.6( 80.450 104,056 89,610 Governance costs 7,662 7,662 7,798 TOTAL RESOURCES EXPENDED 31.268 80,450 111,718 97,408 NET MOVEMENT IN FUNDS 20.416 -20.192 224 -23,008 Transfers between fiulds Total Funds brought forward 100.779 27,445 128.224 151,232 TOTAL FUNDS CARIUED FORWARD 121.195 7.253 128,448 128.224 The Stat¢￿ent of fi[thllcI￿ activities illcludts all gains alld losse5 TecogDÉsed ill the perii)d. All incom¢ and ¢xpenditi]re deriv¢ from wntinuing activiti¢5. The statement of financial artivities #Iso c()mplies with the Tequirements of an income and expendith account llt]der the Companies Act 2006.

FU￿GAL INFECTION TRbST BALANCE SHEET AS AT 30 APRIL 2024 2024 2023 Note CURRfU ASSETS Debtors Cash at baDk 136,897 CREDITORS Amounts falling due within one year 144,79) 136,897 8.673 NET CLTRRENf ASSETS 128,448 128,224 NET ASSETS 128,448 128,224 ACCUMULATED FUNDS Restricted ￿ndS Desionated fun(Ls (iener&l ut]restricted funds io 7,2)3 121.195 27,445 100,779 128224 The charitsble cojnpany is entitled to exemption from audit under Section 477 of the Companies 2006 for the period ended 30 April 2024. The Tti]stees have not required the c])aritable cornpany to obtain an audit of its financial stxtements for the period ended 30 April 2024 accordance with SectiOD 476 of tbe Cornpanies Act 2006. The Trustees acknowledge tbeir responsibilities for. a) ensurints that tbe chaTitable company keeps accounting records that comply Sections 386 and 387 of the Companies Act 2006 and b) preparing financial statemeErts i%hich give a twe and fair vieu. of the state of affairs of the charitsblc ¢OEnpany as at the end of each financial VL7r and of its surplus or deficit for each financial yw in aecordance with the requit¢ments of Sections 394 and 395 and iyhich otheN'ise complv the requirements of the Companies Act 2006 reLating to financial Statemen￿ so far 18 applicable w the ¢haritsble company. These financial statements have been prepated in accordance the special provisioDS of Part 15 of the Companies Act 2006 relating to small charitable CO￿PanI&s 3r.d Mith the Fillancial R¢porting Standard for Smaller Entities (effective April 2008). The fjnancial s ents were approvedby the Board of Tn￿ee$ on 3rf September2024 and were signed on its behalf f C MrJC 10

FUNGAL INFEcrtON TRUST NOTES TO THE AcCou￿rS FOR THE YEAR ENDED 30 APIUL 2024 CHARITY l￿FoR1¥IATION Fungal Infertion 'l'rust is a prii'e eomrAny lirnited bj guardntee irwrpmted in F.ngland and Wa]es. The r¢gistered office is 20 F.Isin8 con(xm b&si5 of a￿o￿ntIllg in twarin8 the fin2n¢ial slatements. Fund 8trwtwc The Cbarity maintsins thc following of fw)dk- De5igTha￿d fi]n￿ rtpresentgrdnts, donations alldl¢8acioreeeived wljich area]loGedbythedonorfor specific purposes. (lentt￿ unrestricted fund rel￿¢5¢￿￿ thJJEstri¢ted income thi¢h is ex￿ndable at the disC￿tion of the Trustees in the furtherdnee of the objeds of ihe cEtsrity. Such a fund may be hcld in order to fina￿Ce ivorking eapital and Capital ini'estm¢nt. There are tjo restricted fun£i% in the Charity. dl Incoming R¢sourcc5 All intoming resource5arc reco￿1￿1 the tharity b&sentitlementwthe re50urcw it is cerlain that all the resources will Ix received and the Jwielar) value of inLx>rnirÈg resoutres can Ir me&sured with sufftcieni reliabilits. li

FUNGAL INFEcfioN TRUST NOTES TO THE Accouiyrs FOR THE YEAR E]WED 30 APRIL 2024 e} R¢sow¢¢3 Expenokd F.xpenditure is rcco8Triscd on an accrual basis &$ a liabslit), 15 Éncurred. Elpenditure includes any VAT which ca]Jnot Ix fully recoverfyi and is reFA)rted &8 w olthe eX￿nditure io Mthich it relate&" Costs of generdting fun(L8 comprise the cosLs a8￿)elated with attractÈng voluntsry income. Clwitable exiKnditure comprise5 those costs incurred bv the charity in the deliN'¢ry of its a¢b￿ltIeS and seThTrces for its beneficÈaries. It includes costs that can be all￿al￿ diT￿tIN 10 such actLNiftes and those costs of an indirect nature nece55aTh" ￿ SUPPDrt theTn. This exwdilure includes all expendiluFe direcU)' related to the objects of Ihe chariiy. CiOVtn)ancc c￿ts incllldc thosc costs a8sKiated ￿1th mectin8 thc constitutional and statutory requiretnents olthe chartty and include the independent &xaminer's fees and Costs linkedto the strategic management of the ¢harÈty". T￿K￿lOn The cl￿￿1>. is ex¢Tnpt from Cort￿10￿ tax ￿ its charitable activstses. DONATIONS AND CIL4NTS Tot21 Total funiL8 Year to 30 ApTiI 2023 Central Unrestritted Designxted Funds Funds 2024 2024 Year to 311.4pril 2024 General donaiio 9.691 9.691 1.533 General th)nations in¢lud¢ sundry thbna*d ￿ the charity mcmi￿rS of the public. No gifts in kind haTre Ixen received in either the current or prwous Nrar. AcrIvtTIES FOR GE￿Ell4TING FUNDS INVESTMEr<r INCOME General Unrtstricted Fllnds 21124 Total fullds Year to Tota] funds Year to 30 April 2023 Dtsignated Futtds 2024 30 April 2024 Bank interest 1,493 ,493 867 J2

FUNGAL INFECTION TRUST NOTES TO THE Accouwrs FOR THE YEAR ENDED 30 APRIL 2024 INCOMING RESOURCES FROM CHARITABLE AcrtVITIES DONATIONS AP4D GRANTS Total funds Year to JO April 2024 Total fi￿dS Year ti) 30 April 2023 G¢tternl UDrestricted funds 2&24 Designated fuDds 2024 (iilvdd 22,4(X) m￿dipharma i.s(K) 15.(KK) 16.5(M) Pfjzer 4.858 4.858 AAA 29,(KbO 29.000 Shionogi 18.¢MKI 18.000 Infection Medical Cha]nlKrs Partnetship iQ(KK> 10,000 40.5 (rf).258 100,758 29,000 COSTS OF CHARtTABLE ACnVITIFS Total fuDds Ytxr to 311 April 2024 Total fullds Year io 30 April 2023 fwnds funds Note 21124 2024 I)on&ions and gtEnts Project costs Trai'¢1 19.644 19.644 80,450 3.962 7.662 9.133 80,477 80.450 3.962 7.662 7.798 31.268 80,450 111,718 97.408 13

FUNGAL INFEcfIoN TRusr NOTES TO THF. ACCOUNTS FOR THE YEAR ENDED 30 APIUL 2024 COSTS OF CHARITABLE ACTivrrIES PROJEcf COSTS Total fllnds Year to 30 April 2024 Total funds Year to 30 April 2023 Uwtstrith Desigoattd lunds fuDds 2024 2024 UniveT5ity of Manchester Research Tcam 41.996 41.996 30,E62 Other aetivity costs 38.454 38.454 50.3 15 80,450 80.450 80,477 GOVERNANCE COSTS Total flllld$ Year to 30April 21124 Totsl funds Year to 30 April 2023 Central D¢sigDated fwids 2024 2024 In5ufdnce l.ega] and professionat Travel and mttting ¢iists Printinglp05tageJ5tationery Accountattcs. fees Bank charges Promotion Costs TrIT Ivebsite Costs 630 13 1406 214 l.iOO 129 630 13 2.406 214 ijoo 129 799 13 1.721 442 1,250 552 2.910 1970 1970 7.662 7.662 7,798 DEBTORS 2024 2023 Inioiced CREDITOILS: AmollDts fallino due withiD Ollc-ytar 2024 2023 Accruals 16.345 8.673 J4

FUNGAL tNFEcfIoN TRUST NOTES TO THE ACCOUNTS FOR THE YEAR E￿￿ED 30 APRIL 2024 MOVEMEiYf IN DESIGNATED FUNDS -NFTKli (ot4 30 Apiil 2024 l Ma). 2023 Aswgillu5 Website 61962 ).258 19,399 103,8?1 8trlla Iluskksson Memorial FuThl 20242 15,015 5,227 I.IFF.-WOrld￿ith (55.759} 46.036 (101,7951 27.445 60258 80,450 7253 ii. RECONCILIATION OF.MOVEMENTS IN GENERAL FUNDS 2024 2023 Defjcit (surplus) of income oi'er expenditure for the year Fun(b at the beginnin8 of rhe >var 20,416 l(X).779 -21.408 79J71 Funds w ¢arry fOr%%￿d 121.195 100.779 12. ANALYSIS OF ASSEIS AND LIABILITIES BETWEEN FLNDS Gtbtrll Unrest￿ted Ik&ign*t¢d run Total funds 2024 I'unEnt assets Cash at bank and in hand Debtors C.UfSEnt liabilitie5 121555 22,238 144.793 -131 -14.985 121.195 7.253 128,448 J5

FUNGAL INFEcfioN TRUST NOTES TO TFtE AccouNrs FOR THE YEAR EM)ED 30 APRIL 2024 APPENDIX Publications supported by the Fungal Infection TnASt in 2023 1. Aissat FZ. Denning DW. Fungal infect￿nS in ￿eria. My¢oses 2023,'66:594-603. 2. Ratemo SN, Denning DW. Burden of Fungal Infections in Kenya. Mycology 2023,. 14.'142-154. 3. Sigera LSM, Denning DW. Invasive Aspergilk)sis after Renal Transplantation J Fungi 2023,'9.'255. (also posted on the Aspergillus websrte.. https.'Ilwww.aspergillus.org.uklnew lreatmenUk￿ney-tranSpIantatl0n/ ) 4. Ahmed SA, Ismail M, Albirair M. Nail AMA, Denning DW. Fungal infections in Sudan.. an underestimated health problem. PLOS Pffl)s 2023;17'.e0011464. 5. Gugnani H, Denning DW. Infection of bats wÉlh Histoplasma species. Med Mycol 2023'.61:myad080. 6. Rodriguez-vargas C. Alastruey Izquierdo A. Denning DW, Atauz AB. Estimated burden of fungal infections in Panama. J Med Mycol 2024"34'.101466. 7. Fathallah A, Chouaieb H. Ben Saief M, Ismali S. Ben Said M, Denning DW. The incidence and prevalen￿ of serious fungal diseases in Tunisia. J Med Mycol 2024,'34-.101479. 8. Al Dhaheri F. Thomsen J, Everett D. Denning DW. Mapping the burden of fvngal diseases in the Untted Arab Emirates. J Fungi 2024,'10:353 9 Gousy N, Adilhya Sateesh B, Denning DW, Latchman K, Mans(x)r E, Joseph J, Honnavar P. Fungal Infections in Ihe CaribiEan: A Review of the L[ler*U￿ to Date. J Fungi {Basel) 2023'9:1177. 10. Sigera LSM, Denning DW. A systematic review of the therapeub"c outcome of mucormyo)sis. Open Forum Infect Dis 2023'11'.ofad704. 16