Charity registration number 1143743
Compny rngistration number 07767248 (England and Wales)
THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
ANNUAL REPORT AND UNAUDITED FINANCIAL STATEMENTS
FOR THE YEAR ENDED 30 SEPTEMBER 2023
111
111
*AD69G72Y*
291rw2024
cC￿PANIEs HOUSE
A14
#236

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
LEGALAND ADMINISTRATIVE INFORMATION
Trusts•$
Mr Percy Beckley
Mr Jonathan S M Craft
Mr Mauri¢e H Craft
Mrs Rachel L Craft
Mrs Mi¢haela M Rees Jones
Mr Laurence J F Tarfo
Amba$$adors
Ms Tiffany Chawner
Ms N￿a Floyd
Mi Julian O'Dell
Mrs Cheryl Kthitehead
Patrons
L(￿dAIl￿ance C8E
Harry & Carolyn Blad(
Barry Boas
Rcoer Cadbury Fam
Harold & Daphne Cooper Charitable Tru$l
Peter & Marityn C(x)per
John ErT
Alessandfo Ousi
Isabel Ettedgui
The Falkm FaNMty
Chades & Diane Herlinger
Michael & Lottie Hunter
Bèvs Malim
Martin O'connor
Sir PaLJI & Lady Ruddo(
Chris Sharp
Michaela M Rees Jones
S•¢rètsry
Mrs Joyce Fletcher (JPI
Charity numb•r
1143743
Company number
07767248
Princi￿1 oddress
2 Regency Chambe
JU￿"1ee Way
Bury
Lancashi
BL9 (XJW
R•gist•r•d office
2 Regency Chambèrs
JubilÈe Way
Bury
Lanix$hi
BL9 OJW

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
LEGAL AND ADMINISTRATIVE INFORMATION
Accountsnts
JS. Actountants & BusinessA(l¥isors Limrted
Jame5 House
Stonecross Bus1r￿S Park
Yew Tree Way
Waffln9ton
Cheshire
WA3 JJD
Bankern
VITgin Money
17-21 Oxford Street
Bohon
Lancashife
8L1 1RD

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
CONTENTS
Pag•
Chairman's statement
Trustees, report
Independenl examine¢s report
Statem￿t of finanual ath"7rfies
9-10
Balan￿ sheet
11
ststement of cash llows
12
Ncrt8S to the finanoal statemenls
13-19

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
CHAIRMAN'S STATEMENT
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Th8 Trustees are very pthsed thal the charity conb.nues to make a posrtive L¥Niiribution in the fiekj of research
improving cancer diagnoslics and treatments.
As in prevKJUS years. Act￿ Against Cancer funded groUndt￿kin9 research at Imperial Col*. LorKlon and at
hyo laboratories at the UnNersity of Sussex. In addition. this year we part funded the eSta￿lshMent of a new
research facility al Anglia Ruskin Univerw, CambrKlge fARU?. Excellenl progress has been made at this new
laboratory. with the recruilment of iwo Postdoctoral Researth Fellows have begun promising projects. There
are rnore details in this report.
t*Jring this year a number of signfficant papers were published wrth results from research ftmded by Action Against
Cancer. As staled in the a￿K>W￿dgrnents of one of ihese papers by the scientist leading the work, Ihe team Yhank
the lat6 Htilary Craft OBE. th8 ￿s￿ary founder of AGlion Ag8inSi Cancer. whose unwaveiing supwrt made this
research possible.-
Fundraising has not as yel re0)ve￿d Sir￿ the Covid pandemrc. Howe¥er, committed supporters ofAct(on Against
Cancer made generous donations and organised wonderful events. I woukj like to personalty thank them and all of
the Patrons, Ambassadors, irLdNhluals. companies, Charitab￿ twsls and foundatk)ns who ry)ntinue to support Action
Against Cancer. Working togelher we can make a tangible dTfferent* for cancer patients.
Mr Maurice H Crafl
Chainnan
Date.. 28 June 2024

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
The Trustees present Ihey report and finawal stslements lor Ihe yeai ended 30 September 2023.
The financial ststements have been prepared in ac￿rd8￿ wrth the accounb.ng poliryes sel out in note 1 to the
rinancial statements and cornpty with the ¢harity's goveming dwjment. the Gompanies A¢A 2006 and
"Accounb'ng and Reporting by Chafilies." Statemenl of Recommended Pradicè applicable to charrties preparing
their accounts in a(¥x)rdance with the Financial Reporb"ng Stsndard appli¢abk in the UK and Republi¢ of Irelan¢J
{FRS 1021 (effetxive 1 January 20191"_
Objectives and •¢tivities
The objedives of the charity have remainèd unchanged. These are lo promole and protecl the health of the
public. in particular by research into the p[evenI￿n. treatsnenl and cwe lor all forrns of Can￿r. Thi5 includes
research inlo pr8Ctical applications for the Pfe¥ention. treatment and cure of cancer and lo disseminale the useful
results of such Tesearth to Ihe publbc. The Charbty Commission's general guKaancè on public benefrt has been
ieferred lo when rewewing our aims and objecti￿$ and in planning our firture aclwits"ès.
SeiÈntifi¢ Advisory Board
Action Against Cancer is privileged Ihal the fc41owry scientists aThJ dir#￿anS have agreed to serve on our
Scienlifi¢Advisory Board".
Professor Heinz-Josef Lenz - Dewty D¥eclor for Research ProJram and Head of Ihe Gasirointestinal Cancer
Program, USC Norris Comprehenswe Canw Cenlre
DrAbby Siegel- Assistant Profes￿r. Oepanmerf of MedrAne. Colwnbia UnNersty Medical Cenlre. New York
Df Siddhartha Mukheriee- A$S￿￿31e Professor of Medicane. CduThbi8 Unive(sity MedKal Cent￿. New York
Profèssor Piamod K. Srivastava- Directot. Carde and Ray Neag Comprehensive can￿ Centre. Connectiojt
Rèsèarth Them•s
All work funded by Acttijn Against Canw fa115 ￿der the follwrvJ research theme5'.
Cancer Stern fAIs
Genetic Swtches
Developing a drug for a tolaty rwi approach to theiapy ILMTK3)
Understanding the c￿cer Brain
Metastasis
Can¢er Stem Cèlla
Cancel Stem Cells ICSCsl On￿ conskn.tute up to S% of a cancerous tum(yJr, but they generate the fast multiplying
Ils that make up the majorty ol the resl. CSCS are also linked to some of the most malignant fealures of
carttr, induding treatment resistance and the ability to spread to other parts of the boty.
It can be many months or even years afler suc£essful trealmenl of a primary tumur. before secondary cancer
SPTeads. This has been desrJit*d a5 if the dandelion has been reTTr￿d frcrfn Ihe lawn. bul the CSC root is left
beky the surface to regrow at a later date.
Acts"on Again$1 Cancer is ftJn¢JiNJ a number of wojeds examinThJ CSCS. lo enable Ihe develowenl of treab))ents
that sp￿￿CallY target them to more lully cut canrArs out by the roots. The saenb.sts ale working to gain
thorou9h understanding Of how CSCS operate and to answer wtal quest￿ such as.
Why do certain pat￿ntS not respond to trealments?
at conditions alhjw sow* tumours io spread wound the toty?
could fijture trealrnents speofKalty target the nK)St malKJnant (41$?

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
TRUSTEES, REPORT (INCLUDING DIRECTORS. REPORT) (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
EXAMPLE OF PROGRE
A research tearn funded by A¢tion Against Cancer ai ImFerial College. London has further developed a powerftjl
genetic system they designed allowing them to manipulate genes in cancer cells. The next slage in the research
has also now been achEved. with the developmenl and integraty.on of specialisl procedures and equipment.
Using a time-lapse rnicroscDpy technKJue. detailed 3D images ol cancer cell cumures were captured al regular
intervals over a SFeuffic lime penod. This allowed for detailed segmentation and da55thcation of cancer gene
nuclei. In combination with other advanced analyss tethniques developed by the learn led by Dr Nina Moderau.
they have gained a deeper underslandiThJ of the genelic diversty and cell ￿mpetitIon observed in certain
Can￿rs. The aim is for this krtrowledge to inform the development of more effective therap￿$ and improve the
ability lo predict and manage cancer trealrnent outcomes.
S". Genelic d"
of
Is rese
Genetk Swttches
Since the mapping of DNA with the Human Genome Projeci, there is greater understanding wthin the scientsfi¢
community of some asF*ds of cancer. In thè past. the vast majority of DNA was bdieved to be 'jtJnk' as il does
nol code fof protein. It was thought On￿ a small amount of DNA was $igntfi¢ant, that whit* tums into single
Stranded RNA. and thon inta protwns respMsitle for the struclures and fvn¢bons we a￿ f￿lIK1r with {b[v￿n
hair. bluè ÈYÈS Ètc}.
However. il is now known that much of DNA is ￿ f*A tranwbed into norvcoding RNAS. sorne ol whith play
important role5 in no￿al biological tunction. gene regulab.on and cancer development. Actton Against Cancer is
funding a range of projects relaied to identfyry rnJn<oding RNAS thal we operab.ng as genet￿ switches caL*sing
cancer to grow or shrink.
EXAMPLE OF PROGRESS.. Pre
and breast cancer discove
A groundbreaking study funded by Action Against Cancef examined how hawng children affects a woman's rtsk
of breast cancer. and the findings were published in a papèr in the prestigious joum31 Nature.
In resear¢h led by Di Bianca$tella Cerese¢$ team at Imperial Colege, London. the team diso)vered that
iyegnancy can actualty (*)angè the gÈneth"c makeup ¢rf brèast th"ssuè. Just likè wrirbkles appear on the skin with
age. changes can also happen in Ihe DNA of breast ￿71$ over lime. The study showed Ihat piegnancy add5 an
extra Iw15t lo these ¢han9es. In oldei women who becorne mothers loi Ihe first tirne. the number of these
changed cells gets bigger cornpared to younger rnolher5 or older women Wbthout children. This mighl mean that
older firsl-time motheis could have a higher ehance of ha¥irbg harmful thanges in their breast cells cornpared to
other women.
This new knowledge can empower women to make informed choices aboLrt their reproductNe health and to tak8
steps to prevent and detect breast cancer earfy.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
TRUSTEES. REPORT IINCLUDING DIRECTORS. REPORT) (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
De¥•loping a drug for a totslty n•w approach to therapy {LMTK31
The idèntification of a new cancer causing gene in 2011 by Professor Georgios Giamas was the earfiesl
Slgnific2nt breakihrough SUPFX)rted by ActTon Againsl Cancer. This gène Cal￿d LMTK3 is nèw to humans. and is
expressed more in cancer c811$ than in normal cells. Those Can¢￿5 that have hKJh levels of LMTK3 are also
much more aggressive.
Since 2011 we have fvnded Professor &amas' research awming to develop an anti-LMTK3 drLg. This woukj be to
overcome the resistance to Ireatments that often develops within patients. bodies.
Many palients respond well to inilial treatment bLrt then develop resistance to it - this is when, with cjjrrently
available Ireatsnenls, their cancer becnmes rnore difficum to treat. A potenlial ants-LMTK3 drug will be
specifically designed lo wort in conjunctDn wilh a patienfs existing trealment. and in a way that overcomes
chemotherapy or hormonal therapy resistan￿, alkyrting these Ifeatments to start wc*king again. Thi5 would be
momentous step in the history ol Car￿er treatmenl.
EXAMPLE OF PROGRESS.. Dfu
discJ)ve
deve
The leam working on this pioneering project have used slnJctUTal biology experiments to generate new findings
that demonstrate the binding eff￿e￿ ol certain compounds to LMTK3. This is an important step as il
means the compounds can ncA¥ be chemically attefed in order to make them b￿d more effectivdy lo LMTK3.
The conlribution of LMTK3 in the behawour of immune cells in ￿rtain cancer types is also being investigated.
The researcher5 have explored the mechanism iM￿lC01ed in this pr￿sS by performing a variety of drfferent
experirnents to delefftiine what changes occ3Jr inside immune cells, when LMTK3 is overexpressed. that
makes them les5 able to attack the cancer cets.
Und•rstanding the Cancer Brdln
11 is thought Ihat cancer cells have a 'brain'. which ts responsible for tuming tt)è cells'on. or'olT. We are funding
sear¢h lo gain a comprehensive understsnding ofthis can￿r brain. by ￿amIng exactly what takes pl8¢e during
the onset and growth of Can￿[- onè protein at a time.
Proteins are present in 811 of the cdls in our t￿y. irnguding in cancer cells. The types of proteins. their quantty,
and the level of their activity can differ belween normal cells and cancer cells. Proleins enable cancer cells to
grow very fast or they can cause them nol lo respond lo a given drug. One of ihe rnain approaches in studying
cancEr cells and identifyin9 riew treatmenl largels is io analyse their protein conlent in great detail.
Action Against Cancer supports researth to undersland can￿r cells, to pave the way for the design of drugs
targeting those profeins that are found to play the most imForlant role in the prOg￿SsiOn of cancer.
AMPLE OF PROGRESS: B
in cancel disco
A team al the Unwetsrty of Sussex made a discovery that ryxjkl hdp to intrease life expe(lan¢y and improve
treatment for an aggressive brain (gncer. whith impads thousands of reople every year in the UK. and hund￿d$
of thousands w0rl¢Jw￿e.
In the Adion Against Cancer stu￿. thè researthws dern¢)nstraled that an understudied protein calod
PANK4, is able lo block can￿r cells from respoThJing to chemotherapeukn"c treatment for the highly intrusive brain
eAn(*r. glioblastoma.
The team ftjrther showed that rf Ihe protern is iemo¥ed. ￿11$ rèspond to the main chemolherapy dw9
used globalty for the treatmenl of g1w)￿as1oma. They ntr4V Iwe to ¢Jwdop a dno to reVe￿e ¢hemo-resislan¢8
and improv¢ ouuook lor palienls.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT) (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Metastssis
When cancer is said to have spread Ihi5 means il has metastasised. This is when cancer cells break away frorn
where they first formed and travel through the bloc*J or tymphatic systems to forni new tumours in other parts of
the body. This development of SeC(￿dary cancer is called metastasis. A melastatic tumour is the same type of
cancer as the primary tumour.
Action Aga*ist Cancer funds a number of projects that are linked to understanth'ng the causes of metastasts. in
order to..
more effectively predict the likelihood of cwrErous cells melastasising {spreadiThJl in each pab'enl.
taihN Ihe testing for patients with a high likelihood of their cancer metast￿'sIng so as to irnprove the
likelihcod of eafty diagnosis.
improve the treatment slrategies for Ihese pat￿nIS once a prOpen￿ty for melaslasis of their cancer has
been identified, thus greatty increasing their thanees of gJNval.
EXAMPLE OF PROGRESS. Bfeast cancer cell communicab.on
Breast Cancer is Ihe most ¢ommon fomi of cancer worf¢JwKle, responytrAe for 25% of tran￿[$ in women. Whilst
t￿atment is effective and curabve in earfy breast t2iicer. meiasiatic disease is intsurabb. The lumtsur
microenvironment of breast fan¢er plays an importanl role in whelher the disease will grow ar￿ spread to other
part5 01 the body. and hL)W rt will re¥KJnd lo trealmenl.
A project at the new research farylty at Anglia Ruskn"n University. Cambridge, part funded by Actitsn Against
Cancer, is delving into the intric*e dynaffli¢5 of breasl i>ncer. The team is exploring the relalronship be￿een
lumour cells and Ihe surrounding tissue. with a pa￿"(￿131 loojs ￿ the role of tslty tlssue. By studying how fatty
lissue cells and tumour cells ￿}llabOrate in guiding communution pathways, the research airns to brjdge gaps in
understanding Iheir molecular interactions. If the researth ideniifies new fatty andlor cancer molecules thal play
a crucial ro￿ in thvse processes, improved di8grb)sb"cs arkl treatments C￿ be developed.
Achlevements and perforniance
Income c4Jnlinues to remain at a rnLK* ky4ver level than durirrfJ pr&Covid pandemic times. A smam number of
lundraising events took place during the year. induding noiabty Catfesl and A Movabbe Feast, which combined
raised more than £100.CQO.
Everyone involved with Action Against Cancer is eno￿￿ gratefijl to the indi￿dUalS, companies and trusts
and foundations that ha¥e donated towards our work.
We are incredibly proud of the groundbreaking work the soentists in ihe laboratories at Imperial Col*e. London.
the Universty ol Sussex and Anglia Rusknn UnNeisrty, Cambridge have achieved thjring the year.
Below is a Samp￿ of published papers deScri￿ng work wholty or partty funded byActm Against CancEr.'
1. The mutational landscape of the adutt healihy parous and nulliparous human b￿aSt
2. Thè role of non-coding RNAS in extra￿llular vesides in breast cancer and their diagnostic implutions
3. Comparison of phenom￿ and CIDNA in a large breast screening pokxJlab"on." the Breast Screening and
Moniloiing Study IBSMSI
4. The inhibitory propertes of a nosel sdeclNe LMTK3 knnase inhibrt

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT) (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Financial review
During the year the tharity's income from au sources amounted lo £325.36S (2022.. £508.2261. In the same
perii)d, expendilure on charitable adivibes totamed £389.577 {2022". £477,732), and the (x)st of raising funds
lolalled £72,58612022'. £71,￿￿_
Accumulated funds as at 30 Septemter 2023 totalled £2,046.815l2￿22: £2.183,5931. Thè TnJstees consider thal
the financia1 position as at 30 September 2023 is satisfactory. Approximately hvtsthirds of these lunds linduding
those in Unrestr￿ted ftjnds) have been awarded to apwoved projects {see Note 131.
11 is the poliw ol ihe charity ihal unrestricted fvnds which have not been designated for a speufic use should be
maintained al a level equivalent to be￿een ihree aTrJ SVA months expendilure. The Truslees CLJnsider that
rèseNes al ihis level wll ensure that, in the event of a sgnrficanl drop in fvnding. they wll be able to continue the
charity's currenl activities while consk1eration is given to ways in which add￿onal funds may be raised. This level
of reserves has been mainlained throughoul the year.
Plans for the future
The chaiity will rA>ntin￿ to lund all of the projects already approve(l. and to fundraise io support other ￿searCh
aiming lo further undèrstand cance¥ and how to bettei dognose and treat rt. The charty will continuè to
disserninate rèsults of ￿searth in published s(jentif￿ papers. M the oryanisatw)n's websiiè wd in rÈgular e-
newsletters.
Structure, govemance and managem•nt
The charily is a ¢x>mpany limiled by guarantee. WKxJfpoTated on 8 September 2011 and registered with the
Charlty Comrnission on 9 Septembw 2011. The caff*s out it5 a(*ivities using the wryking name Action
Against Cancer.
The Trustees, who are also the directors for the purpose of cc*npany and who served during Ihe year and up
to the date of signalure of the finartcial statements were..
Mr Percy B&Wey
Mr Jonathan S M Craft
Mr Mauric* H Craft
Mrs Rachel L Craft
Mrs Michaela M Rees Jones
Mr Lauren¢e J F Tarbo
The Board of Trustees is authorised lo appoint Trustees to fill vacancies arisin9 thiough Ihe resignatK>n
death of an existsng trustee.
None of the TwstÈes has any benefiual inlÈrÈst in ihe o)mpany. All of the Trustee$ are member5 of the cornpany
and guarantee io contribute £1 ir) the event of a winding UP.
The charity be￿ffts from the provision of *¢omNKMlation and admintstrative supwt from QF Holdings NW
Limited. a company that is cnntrolled by r£rtsin of the Trustees of Ihe thaiity. Nr) monetary value can be
attribuled lo this supwjrt, and Iherefore rt 15 r￿1 induded in the Iinaw* stslements.
There ale no other transactions wilh relate(1 parbes. The Trusws maintain a register of interests, whtch is
updated at meeting.
The Trustees have assessed the maD)r risks to whith the d)arrty is exposed. and are satisfied that systems ￿e in
pla￿ to miti.gale exposure to thè major rsks.
Inlemal ¢ontrol ri$k$ are minimise<1 by th8 wnplementation of wcodures for aLrthorisation of all transactions and
projects.
Pro¢edure$ a￿ in place to ensu￿ complk4ice with heamh and safety of staff. vo￿nteerS. dients and MSTtors.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT) (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
On behall of the board of Iruslees
Mr Mauri¢e H Crdft
Trustee
Dated.. 28 June 2024

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
INDEPENDENT EXAMINER'S REPORT
TO THE TRUSTEES OF THE HILARY CRAFf CHARrfABLE FOUNDATION LIMITED
I report lo the Trustees on my exarn1nat￿ of the ffinanual statements of The Hilary Craft C￿?￿lab￿ FoundatK•n
Lirniled Ilhe charity) for the year ended 30 September 2023.
RvJpon$ibilitiÈ# and basis of report
A$ the Trustees of the charity land also lis direclois for thè KMMrx)ses of (xsmpany lawl you arè responsible for the
preparation ol th8 finarKi¥l slalem$nts in accordance with the requitemenls ol Ihe Companies AL# 20C61th8 2006
Adl.
Having satisfied mysew that the ffinancial stalements of the cw are r¥)t required to be audrted under Part 16 of
the 2008 Act and are eligible for independent examinathm, I report in ￿SPect of my examination of the charrty's
financial slalements carr￿d oui under section 145 of Ihe Chariiies Act 2011 (the 2011 Act). In carying out my
examination I have lollowed all ihe applicable Directk)ns given by the Charity Comrnission under section 14515}Ibl
of the 2011 Act.
Independent exafflinerfs statement
Since Ihe charity's gross incDme exceeded £250.CfKJ yfMJr examiner must be a member of a boty listed in section
145 of the 2011 Ad. I confirm that l am otJalrf*d to undertake the examinaiK>n t￿uSe l am a member of ICAEW.
which is one of the lisled todJ"es.
I have cofflpleted my examinalK)n. l ¢wfinn that no matters have come to my attentp)n in cA)nnectiw wilh the
exarnination g￿ing me cause to belEve that in any material respeGt-.
accounting records were not kept in respect oflhe chanty as required by section 386 of the 2006 Act," or
the financial statemenis do not accDrd with those records., or
Ihe finan(aal statements do not u)mply with the accounb"n9 rewKements of sect¢on 396 of the 2￿6 Ad other
than any ￿qUiremen1 that the accounts gNe a Irue an¢J fair ts nol a malter considered as part of
independent examination", or
the finanaal statements have not been prepared in accordance with the methods and principles of the
Stalement of RecOmme￿led Practice for aco)unling aThJ reporling by charib'es applicable to Charit￿s
prepar¢ng Iheir accounts in accordance with the Financial Reporting Standard applicat48 in the UK and
Republ¢c of Ireland IFRS 102).
I have no ¢on¢ems and have come a¢ross no other malteTS ￿ ¢onnedb)n wrfh the examinab.on lo which attenlw
should ￿ drawn in this repurt in order to enab￿ a woper urwjerstsnding ofthe finanaal stalernents lo be feached.
(LS
JS. Aceountsnts & 8usinÈss Advisoys Llmlted
PetsrAtkinson F.C.A
James House
Stonecross Business Pa
Yew Tree Way
Wdrringlon
Cheshire
WA33JD
Dated. 28 June 2024

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
STATEMENT OF FINANCIAL ACTIVITIES
INCLUDING INCOME AND EXPENDITURE ACCOUNT
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Current financial ye•r
Unrnstricted Restri¢tsd
run
lunds
2023
2023
Totsl
Total
2023
2022
Income from:
Volunlary in¢om•
Investments
182,550
42.618
1W,197
282,747
42,618
501,221
7,005
Total income
225,168
1(￿.197
325.365
508,226
Ex
endlture on..
Raising funds
72.566
71,907
Charrtable ath"vrt*s
377.059
12.518
389.577
477,732
Total
449.625
12.518
462,143
549.639
Net lexpenditure)fin¢om* tor the yearl
Net mov•m•nt in funds
1224,45n
87.679
{136.778)
{41,4131
Fund ba18nc*s at 1 October 2022
2.171,316
12.277
2.183.593
2.225.OC6
Fund bala￿e¥ at 30 Sèpt¢mbèr 2023
1.946.859
99.956 2,046.815 2.183.593
The statement of financial activities includes all gains and losses reccrfJnised in Ihe year. All income and expenditure
derive from continuing activities.
The slatement of financAal activities also Complie$ with the requirements for an irKome and expenditure attount
undw the Companies Act 2CiI6.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
STATEMENT OF FINANCIAL ACTIVITIES {CONTINUED)
INCLUDING INCOME AND EXPENDITURE ACCOUNT
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Prlorfinancial year
U￿￿trIcted Restricted
funds
funds
2022
2022
Total
2022
Motes
Voluntary income
Investrnents
464.027
7.Tr)5
37.194
501.221
7.005
Total incom¢
471,032
37,194
508.226
nditurè on:
Raising funds
71.￿)7
71,907
charrt$b￿ aijwities
339.665
138.[￿7
477.732
Totsl
411.572
138.067
549,639
Net leMpenditure)finct)mt for the ye•rl
Net movèment in funds
59.460
I1￿,873)
141,413)
Fund balances at 1 October 2021
2.111.856
113.150 2,225.006
Fund balanc•s at 30 September 2022
2.171.316
12.277 2.183,593
The statement of finaThial actNities iThSudes all gains and losses recognised in the year.
The slatement ol financial actiwties indudes all gans and losses re(J)gnised in the year. All *xome and expenditwe
derive from continuing acliwlies.
The statement of financial aC￿VitieS also complies wilh the reQ￿rementS for an irKome and exPend[tu￿ account
under the Cornpanies Act 2006.
10-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
BALANCE SHEET
AS A T 30 SEPTEMBER 2023
2023
2022
Notes
Current ass•ts
Debtors
Cash al bank and in hand
io
436
2,1th).020
391
2,239,418
2,1￿,456
2,239,809
Creditors.. amounts falling due within
one year
11
(53.641)
156.216)
Nel current assets
2.046.815
2,183,593
Funds ofthe charity
Restr￿ed fuThls
Unrestricied funds..
General unrestrided fun(J$
DesKJnated fijnds
12
99.956
12,277
705.222
1.241.637
658.197
1,513,119
13
2.046.815
2.183.593
The company is eniiued to the exemption from the audrt requirement contained in section 477 of the Companies Acl
2CW)6, for the year ended 30 Septethr 2023.
The directors acknowledge their respon￿bilrtieS for complyin9 wth the requirements of the Companges Act 2008
with respect to accounting records and the prepwat*)n offw)ancial statements.
The rnembers have not required the company to obtain an audit of rts ffinanoal statements for the year in queslion
in accoidance with section 476.
These ffinanryal slalemènts have been p￿pared in attor￿ar￿ vrith the rMovisK)ns applicable lo o)mpanie$ stsbject
to the small Companies regime.
The financial statements wefe aPPToved by Il* Tnjstees on 28 JU[￿ 2024
Mr mauri￿ H Craft
Trustetr
Company Registration No. 07767248
11

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
STATEMENT OF CASH FLOWS
FOR THE YEAR ENDED 30 SEPTEMBER 2023
2023
2022
Cash flows from operating activities
Cash absorbed by operations
16
1182.016)
170.5781
Inve$ting aetlvftlg$
Investrnent income received
42.618
7,005
Net cash genernted from investing
act[vi￿•S
42.618
Net cash used in financing activities
Net d•cr•as• in cash ab)d Cash equivalents
(139.3981
{63,5731
Cash and cash equNalents at beginning of year
2.239.418
2.302.991
C*¥h and caBh equivalents at end of year
2.1￿.020
2.239.418
12-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Accounting policies
Charity Inforn)ation
The Hilary Craft Charitable Fcl￿daI•)n Limited is a private c4Jmpany limited by guarantee incorporated in
England and Wales and a registered charity in EnglaTrJ and wa￿5. The registered office is 2 Regency
Chambers, Jubilee Way. Bury. Lancashire. BL9 OJW.
1.1 Accounting convention
The financial Statements have been prepared in aC￿rdan￿ with goveming docurnenl, the
Companies Act 2006 and 'AcLounling and Reporting by char￿"eS.. Slatemenl of Recommended Practice
applicable to Charit￿s preparing Iheir accounts in aCt0rdan￿ with Ihe Fin8nryal Reporting Standaid
applicable in the UK and Republic of Ireland IFRS 1021" {a5 arnended for accounting periods commencing
from l Jarwary 20161. The charity is a Pubhc Benefit Entty as defined by FRS 102.
The ￿nanc￿l statements are prepared in sterfing. which is the functional ￿Then¢Y of the charity. Monetary
amounts in these finanual ststements ace rounded lo the nearest £.
The financial statements have boen p￿pared under the histor￿1 cost convent*)n. The principal accounting
policies adopted are set oul t*low.
1.2 Going eoncem
At the lime ol appromng the finanaal siatements, the TNstees have a reaSona￿e expectation that the charity
has adequate resources to continue in operational existence for the foreseeable fvture. Thus the Trustees
continue to adopt the going concem basis Of￿)Unt￿g in preparing the finanaal statements.
1.3 Charitable lunds
Unrestricted fvnds are avalable for use * the disc*eb"on of the TnJ$tees ift fvrtheran¢e of their charitable
objectives.
RestrNXed funds are subJ"e¢l to spe¢ifi¢ c4)ndilions by donors as to h(M Ihey may be used. The purposes an¢J
usès of the restricteil lunds are sel out in the notes to the ￿Ounts.
1.4 Income
Inwme 15 recognised when the charity is *alty enlitled to rt after any perf0rnan￿ condit￿nS have been met,
the amounts can be meas¢Jred reliabty, rt is prOba￿e that income will be recewed.
Cash donations are recognised on r￿1p1. Othei donabons are fe(x)gniseil once the tharity has been notffied
of the donatK)n, unless performance conditions require deferral of the amount. Inwme lax recoverable in
relab.on to donations receNed under GiftAKJ or deeds of covenant 15 recogni5ed at the time of Ihe donation.
Legaaes are recognised on rw*ipt or otheMise rf the tharity has been notified of an impending ¢Jistribulk)n.
the amount is known. and receipt 15 expected. If the amount is krx)wn. the le9￿ is Irealed as a
¢orbtingent assei.
Donated seNees aTe re¢c*Jnrse<l as in¢>ime when the tharity has control over Ihe item. any cOr￿lI10n$
associated with the Jtem have been mel. thè reeèipt of thè e￿nOMiC bènèfrt from the use by the charity of the
rtem is wobable and the the econoffl￿ be[￿ffi can be measvred reliabty.
On ￿￿1pt, donated services are re￿nised on the basis of the value of the gift lo the Ch￿tY which is the
amtsunl the charity woukl be willing to pay to oblain servrces or tsalit￿S of equivalent economic benefit on the
open market". a Corresponding amount is then reco9nised in expenditu￿ in the period of re￿ipt.
13-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Accounting polici•s
(Continued)
1.5 Expenditure
Expenditure is recwised on Ihe ba&s.
Fundraising costs ale those irtDJrred in generaling fund5 and do not indude the o)sts of disseminating
information in support of the Charitab￿ aclwities.
&Jpport costs a￿ thosè ujsl incajrred dwecty in SLwori of &xpendrtU￿ of the obie(as of ihe charity.
Overhead costs are albcaled on the basis of Ihe actual Spend by acliwty.
1.6 Cash and eash •quivalÈnts
Cash and cash equwalenls Èndude cash in hand. deFKJSts he￿ at call WTth banks, other short-terrn liquid
inveslments with original maturities of th￿e rfy)nths or W. aTrJ bank overdrafts. Bank overdrafts are shown
within borrowings in ￿J￿ent liabilrties.
1.7 Financial instruments
Thè charity has elected to appty the prowsion$ of Sedion 11 'Basic F￿anUal Instruments, and Seclion 12
'Other Finanaal Instrnments Issues, of FRS 102 to all of its finanual instruments.
Financial instruments are recogntsed in the charitys balance sheet when Ihe charity becnmes party to the
contractual provissons of the instrument.
Financial assels and liatslities are offsel. wilh the nel amoLtnts presented in Ihe finanaal statements, when
there is a legally enforceable righl to set off the recognised amounts and there is an intention to settle on a net
bas(s or to realise the asset and seltle the liabthty S1￿￿j11ane0u$ty.
Basic flnancial assets
Bast¢ financial assets, whi¢h indude debtors and cash and bank balan￿5. are initially measured at
Irans8clDn pnce indudirvJ transadion costs and are subsequently carried at amortised CLJSt using the effective
interest melh(xJ unless the afrangement ¢onstrtules a financing transactiorb. where the IransactDn is
measured 81 the present value of Ihe futu￿ receipts dis(X)￿led al a market rate of interest. Financial assets
dassified as r￿e7v31￿e wrthin one year afe ntx al￿Ntised.
Derneognition olllnaneialassots
Financial assets are derecognised onty when the contractual rights to the cash flows from the asset expire or
are setued. of when the tharty transfers the finanual assel and subslanlralty all the risks and rewards of
ownership to another entty, or rf sorne signfficanl risks and rewards of ownership are retained but control ol
the asset has transferred to another pwty that is able to sem the asset In its entirety lo an unielated third party.
Basic financial liabilities
Basic finanaal liabilits'es. indLthg ueditors bank fv)ans are inth'ally recognised al transaction pricè unlèss
the arrangement constrtutes a financiThJ transaction. where Ihe debt Inslrumenl is measured al the present
value ol the future payments disCoL￿tell at a market rale ol interesl. Financial liatslities ckssrfie(l as payablè
within one year are not amorti5ed.
Debt instruments are sub5equentty carwie(l al arn￿￿ed cost. usry the effedjve inleresl ￿le method.
Trade creditors are ob19atior￿ to pay for 9oods or seNces that have twi a(4uired in Ihe ordinwy course of
operations from suppliets. Amounts paYa￿e are ClasSrf￿d as current liabilitiès rf payment is due within one
year or less. If not, they a￿ presented as non-currenl liabilities. Trade ueditors are rerA)ynised irulialSy at
Iransaclion pri¢e and subsequenuy measured al am0￿.sed ￿st usng the effe¢ttve inleresl method.
14-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Accounting policie8
(Continued)
Derecognition of financial liabilities
Financial liabilities arè derecognised when the d)ariVs contractual oblwJ*ions expire or are discharged or
can¢elled.
1.8 Employee beneffts
The cost of any unused holKlay entitlement is recognbsed in ￿ wiod in whith the employee's SerV￿S are
re￿Ived.
Terminaiion benefrts are recognised immediatety as an expense wthen the charity is ￿eTr￿nstrab1y cormiitted
to terminate the enwbyment of an employee or to provide temination beneffts.
1.9 Retirement benefits
Payments to defined c￿nt￿bUt¢On retirement benefrt schemes a￿ charged as an expense as they fall due.
Inc<Jme from donations and le9actes
UnTrstricted Res1rlcted
funds
funds
2023
2023
Totrl Unrèstricted Restrletsd
funds
funds
21122
2022
Total
2023
2022
Donations and 9ifts
Fundraising events
1S8,251
24,299
1LTh).197
258.448
24,299
464,027
12,194
25.(XJ)
476,221
25,CX)O
182.550
1CK).197
282.747
464,027
37,194
501,221
Income from investments
Unr¢$tri¢tsd UnrnstrScted
lunds
funds
2023
2022
Inte￿$1 ￿¢￿Vable
42.61B
7,005
15-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
ai$ing fund¥
Unre$tricted Unrestrieted
fund$
funds
2023
2022
Costs of generating voluntary incorr
Travelling and subsistence
Printing, stalionery and poslage
Fundraising expènses
Other expenses
Advertising
Other fundraising costs
Staff costs
Insurance
112
112
1.091
463
298
475
615
67,958
895
711
68,503
934
Costs of generating voluntwy incc¥ne
72,566
71,907
Charitable activities
Unrestricted Restricled
2023
2023
Total un￿(lIcted Restricted
2023
2022
2022
Totsl
2022
LMTK3 drug development
Cancer stem cells researth
PhD and other student
bursanes
Ovarian cancer research
Pancreatic cancer research
Genetic switches
Breast can(*r rese8r¢h
Other researc* project
143.242
743,242
8288
91,781
91.781
1￿,813
8.288
1CQ.873
64.622
12,627
25.238
66,530
73,850
64,622
12,627
25.238
66.530
111.044
2.817
51.178
176.321
194
2.817
51,178
180.551
194
4230
37.194
373.752
12,518
386.270
334.648
138,067
472,715
Sharè of govemancè costs
{see note 61
3.307
3.307
5,017
5,017
371.059
12.518
389.577
339.665
138.1￿7
477,732
Analysls by fimd
UnrestrKled funds
Restricted funds
377.059
377.059
12.518
339.665
339.665
I38.￿7
12,518
138.C67
377.059
12.518
389.577
339.E65
138,￿7
477.732
The other rese*th project is mainty ￿ relakn lo a projed on tumour micromanagement.
16-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
Support costs
Support costs Governance costs
2023
2022
Audil fees
Independent èrdminatK>n fèes
Bank charges
Professional fees
4.050
2.000
560
747
2.OLM)
560
747
324
3,307
3,307
5,017
Analysed befvleen
Charitable actNities
3.307
3.307
5,017
Govetnartce wsts indude £2,(MJJ 12022." £4.0501 in relalion lo a¢¢ountsnw fees payablè to Ihè independent
examiner12022'. auditor). These semces We￿ don*ed by the indÈpendÈnt Èxaminer and hencè are induded
vrithin voluntsry irKx)me.
Trustees
Nonè of the Trustees lor any persons comeded V￿th them) received any remuneralh)n or beneffts frorn thè
charity during the year. A close family member of a trustee was remunerated for athinistrative serv￿$
provided in the year tolalling £15,(KQ {2022.' £15.(￿1.
Employeés
The average monthly numbef employees during the yeai was:
2023
Number
2022
Numbèr
Management
Employmènttosts
2023
2022
Wages and salaries
Soaal seujrity costs
Other pens￿ costs
65,524
1,690
1.289
64.250
2,42S
1.283
68.503
67,958
No employees had anNJal remuneralion of£60.LIXJ ¢y more.
Many of the r¢searth projects invofve the use of PhD students. Action Against Can¢er is currentty furnling
number of PhD sludentships and fellowshps at lrnperial College. L￿7th)n and ARU, Cambridge to support
the ￿search work
17-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
NOTES TO THE FINANCIAL STATEMENTS {CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
T•x*tion
The ¢h8rity is exempl from tax on income and gains lalling wrftiin section 505 of the Taxes Ad 1988 or section
252 of ihe Taxation of Chargeable Gains Aci 1992 10 the extent that these are applied to its ¢haritable objects.
10 Debtor¥
2023
2022
Amounts falling due wilhin gno year.
Prepayments and aclyued ino)me
391
11 Creditors: amounts falling due withln year
2023
2022
Trade creditors
Olher ￿dItorS
51,728
1,913
54,422
1.794
53,641
56.216
12 Restrlcted lunds
The restricted funds of the tharity comprise the unexpended balances of donations and grants held on trust
subject to specific conditions by donors as to how they may be used.
Movement In funds
Mov•mènt in lunds
B•lanc•ai Income Eywndituve Pa*nc¢ •1 Income Eyndilufg
1 Ocioter
1 October
2021
2022
Balan¢e at
30 SeptÈmbgT
202J
ARU Laboratory
Cancèr slem cells
rèsearch
Breast cancer research
95.￿7
95.￿1
113.150
11LKI,8n) 12.277
{37,194}
18.288}
14,230)
3.989
37.194
113.150 37.194 {138,C67)
12.277 1CQ,197
{12,5181
99,956
The research work being undertaken ts desuibed in detail n the Trustees. Rewt under Research Themes.
18-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED
ACTION AGAINST CANCER
NOTES TO THE FINANCIAL STATEMENTS (CONTINUED)
FOR THE YEAR ENDED 30 SEPTEMBER 2023
13 Designated funds
Out of Ihe total funds of £2,046.815 availabb, indudirrfj unrestn.cted ￿1x)rne, ftJnd$ have been awardèd to
approve¢J proiÈcts where planned luturè expendrture ovèr the nèxt fv40 yèars is ¢alculated lo be £1,341.593.
Of this, £99,956 are restrided funds and £1.241.637 are unrestricted funds
Oesignaled fLmds were awarded to projects wthin the research themes sh(rwn in the table below.
ramme area
Genetic Swi1ches
LMTK3
CSC'S
UCB
Metastasis
ARU LatM)ratory
Totsl
unds desi
203.434
85S.(KH
8Q.034
14,618
ated
cted
n￿trIcted
203.434
856.004
76.045
14,618
388
95.968
1.241.637
15.2
3.989
187,115
1,341.S93
95,967
99.956
13.9
l(X).00
14 Analysis of nel ¥ss¢ts betwt•n funds
Unrestn"¢ted
funds
2023
R•strict•d
lunds
2023
Totsl UnreStr￿ted Reslricted
funds
fLmds
2022
2022
Total
2023
2022
Fund balanres al
30 Septernbef 2023
are represÈnted by-
CU￿nt
asselsllliablities)
1,946,859
99.956 2.046.815 2.171.316
12.277 2,183.593
1,946,8YJ
99.956 2.046,815 2.171.316
12,277 2.183.593
IS Related party trdnsactions
Other than as disdosed in note 7. there ￿re no disclosable related party transa¢lions during thè year (2022-
none).
16 Cash generated from operations
2023
2022
Defityl for thè year
1136,7781
{41.4131
Adjuslments ft>r.
Investment in¢ome recogThsed in statement of finanoal ac1￿￿11¢$
142.6181
17.0051
Movements in workiThJ ¢apita'.
(Increase) ￿ debtors
IOe¢réasÈ) in ¢redrtors
1451
12.575}
1101
122,1501
Ca$h ab$orlJed by operations
1182,016}
170,5781
17 Analysis of ¢hanges In net funds
The chafity had no malefol debt durrng the year.
19-