2021-09-30-accounts

Ch¥tty Tr9lstr#tion wmber 1143743 Compary registration Nmber07767248 (England and Wales) THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER ANNUAL REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 SEPTEMBER 2021 *A8CP4QRHC' 1610912022 OMPANIES HOVSE A21

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THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER LEGAL AND ADMINISTRATIVE INFORMATION Trustees Mrs MKhaela M Rees Jors Mf Mawice H Craft Joftalhan S M Craft Mr Percy BetJey Mr J FTa Ambassado Mrs lfjrsty Ettrick Mrs Chèryl lthitehead M5 Tiffany Chawner Ms ￿)la Floyd Mr j￿lan O'Del Mrs Caterna Ut)el F¥tro L(dHAar￿e C Bwry Boas Roger Cadbwy HarohJ & Daphne CooFer Charitable T￿￿t Peter & Martyn Cooper Jthn Ernery Isthl Eitedgui The Falkjn Famty Leonard & Reree Fnstein Charles & Clane Her￿nger hael & Lolie H￿ller Bob Lefroy Bes Malim Marlin O'c￿l￿)r &r MKhad Pathson CBE S4r pa￿ & Lady Rudthk Iw)r & ISa￿le Std( Chris Sharp cha M Rees Jones Secretary Mrs Joyce Fletdw lJ.P.) Charity number 1143743 C￿npanY number 07787248 Principal address 2 Regèncy CPwThbers Bwy La￿aShire BL9 CUW Règistered offic• Jthlee Way Bury Lancash¥e BL9 QJW

THE HILARY CRAFf CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER LEGAL AND ADMINISTRATIVE INFORMATION Auditor J3ck50n Stephen LLP Jarnes House Stoneryoss Busvw P•k Tree Way trington Cheshwe WA3 3JD Bank•rn Ycfkshire Bank &9 The RodE Bury . BL9 DYB

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER CONTENTS Pag• Chalman's ststèm8 Trustees. rewt Statemen¢ ofTfUStees' Tesrwsil¥htres Ind•pondent auithtofs rep)rt 9-11 Statementoffinanrialae￿￿theS 12-13 14 Slalement ofcash Ibws 15 Notes to Ihe fv)￿l￿al slalenwts 16-23

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER REPORT ON BEHALF OF THE CHAIRWOMAN R?R THE YEAR ENDED 30 SEPTEMBER 2021 As v41th the maN)rity of charitiès tht Ccmd 19 pandern￿ ha5 sevÈfety affeded the abl￿ty to raise fthds. Th• continLd travel rè51ridions rneant Ihat no raisry events were Fossible in the year and the level of income has ¢ontinLpd 10 be Sub51antia￿ bek)w those athieved wior b) Cwd 19. It bè scffte twnè before thè sitLAtic retums to nowmal and the income ￿Ve1 for Ihe coffwrvJ year ￿ Unth)￿1tedty be belrmt rwnal expectstsons. Oe5Pite these wobierns there have been posiiNe resuls from ow fijnthry of cryhtinued research as ouuined in the publirath)ns in medical joumals as detai18t1 li the RepJ1 of the Trustees wthin Ihese financAal statements. The researth continues at lrnpeiial Comege L¢￿￿ and Ihe c4 Sussèx wherè Professor ￿910S Glamas continues to mak• sxogress on d￿ek)K¥￿￿I ol an anti LMTK3 d￿￿. There are many n￿)re research proj&ds that the Charity wi)uld wish to SUFWrt this be ￿tr1ded rfthe level of funds raued c(Minues at the cwrent rate. A major legacy of my vlife and the pre¥kx￿ Chairwornan. Hilary Craft OBE was the fowKlatk)n of thi5 Charity. and al the Trustees a￿ deternined to continue to fijnd Ihe irnp)rtant plOre￿Tr9 research work that I supports. personalty would Ike to ihank ihe Patrons. Ambassadots. indmduals, CA)mpanEs and charitsbk irusls and loundati¢)ns who continue lo support Ackn Against Carter. My W is that tog•th•r wè T•AI be able to raise Iha ds req￿￿ to o)nthiue the Imwlant researc*. aurfce H Craft Tru ee Oatèd.. 29 Jlty 2022

THE HILARY CRAFT CHARrrABLE FOUNDATION LIMITED ACTION AGAINST CANCER TRUSTEES, REPORT (INCLUDING DIRECTORS. REPORT FOR THE YEAR ENDED 30 SEPTEMBER 2021 The TnJ$leès prtsent thr report andfmaneialstatements kn the year ended Xs September2021. The finandal statemenls have been Fyepared ID wilh the ai>)xmiry poSi¥e5 set out in note 1 to Ih rinan¢i?l $taternents and compty wth the tharity's govaning douynent. the C¢)mpanies Act 2006 and "Accountin9 and Reportww ty Chafilies". Statement of Recrynmended Prtctth apph'cable to thawiti2s preparing theSr acwunts in acc¢ydance with the Fina￿¥81 ReFryting Slandard applrtable n the UK al￿ Rep￿￿ of Ireland IFRS 1021 (effective 1 January 2019)". ObjoetTrves and activltles The objectivès of Ihe tharity ha¥e remained undonged. These we kn ￿￿)mote and wotect Ihe health of the wblK, ￿ particular ty research wrtti the prewtH￿. treatsneni and tsjre for ￿1 fonns of Cancer. This inclut1es researth into practical applicatKJnsts the pre¥entw,treatrnent and cwe ofcancer and to di5sefflu)ale the usefvl resuhs of $uth reseafth to the put4ic. The Charity Commissh's genernl guidartce ¢)n pubh"c benefit has been referred lo when reviewing airns and ￿'earleS and in p1aftnw￿ cyJr fuiwe athb"es. Sclentlfic Advisory Board Aclx)n Against Cancer is wp4ileged that the fc41)wry suenlists WKI thpians have yeed to seNe on our ScientifKAthsory Board.. Prolessor Heini.Josef Lenz - Director for Ckntsl Resea￿ and Ct>Head ol the Gl Caneas Pfogran USC Norris CompTehensNe Cancer C)tre. Prnfe5sor of MedKiie ￿ PrewentatTrie Me¢icine, Keck School of MedirAne. Unpièrsity of Southwn Cawomia DrAbby Sie9el-Assistanl Professor. DpartrTWt of Medi(ine. C¢)lumbia UnpM5rty Vedtsl CÈntre. New Y¢)Tk Dr Stdthartha lthjkheqee . Assislant Professor. Department ol Medicffie. c0￿MÈla. UnNwsty Meth'cal Cenlre. New Yuk Piolessor Pramod K. Siiwdsts¥a. D￿e(￿or. Cam aTrJ Ray Neag CMwehensNe canCerCent￿. Connedicul Research Them•s All wcrfk lunded by Ackn Againsl Cancer fats ￿derthe fol(Mng researththemes.. Cancer Stem Cdls Geneticswitches Developing a drug fcrf a totalty nvwapproach trj thernpy (LMTK3) Understanthng the Cancer 8rn Metastasis n¢er Stem Cè115 Cancer Stem Cells {CSCsl onty constibjte w) to 5% of a canceThs tunI￿r. trmjt bw generate the fast M￿ti￿Y1ng cells that make up the majoiity of the resL CSCS are also ￿ked to some of tr)e most malignant lealures of cancer, Inc1￿j1ng Ireatment rÈsistsncè and fv at4ty to spread kn Other parts ofthe t￿dy. ft can be many months ¢x even years aftw successful treatrnent of a prtsnary tumouT. before secondary cancer spreads. This has been des¢thd as rf the dartddi￿ has been removed from tr the CSC root is left below Ihe Surfa￿ to regrow at a laier d. Adion Against Cancer is a number of prcts eX￿inry CSCS. to enatle Ihe devdok¥n￿t oftreatments thal specffically target Ihern - to more ftjfy (xrt ￿nCerS wi by Ihe roots. The 5(aenti5ts are Work￿79 to gain a thorough undetst3r￿1ng of how CSCS Op￿￿e and to answermtal questI￿S suth as". . ￿Y do certain patients Th)t reS￿￿j to trealm￿ts? . IAffiat ce4)dil￿$ $￿e ttunows to sweJ ar0￿d tt* body? . Fbjw could firture treatrnenls spe0fiC￿ty Wet the most malignantce15?

THE HILARY CRAFT CHARITABLE FOUNDATION LIMtTED ACTION AGAINST CANCER TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT) (CONTINUED) R)R THE YEAR ENDED 30 SEPTEMBER 2021 EXA￿LE OF PROGRE Aciion Againsl Cancer is fundin9 an inno￿tiVe cancer stem cells resèareh rKoieth by Pwfessor Ju$￿'n Stebbing arKI Dr Nina ModeFaU at ImFerial College Lortdon. They are devetcoiwwj a crmbination of new tools and techniques for breast cancef palients. to ￿derstan(l Iheir Se￿ndary tumours befo￿ they even devèlo It is not Ihe rxirnary tumour that causes latalty for most ￿$t ￿Cer pati&)Is. trArt Can￿r spreading {rnètastasisingl around the body. Fty t¥east caTh, the Ser￿dary tv meta5tab'c lumou￿ develop ￿ the txain. bones. Iwtgs LY INer. Despite carefvl 5tudtes, it is stl unkno￿ how ce15 decidè %¥there they will migrate to and LYOW tumours. One of thè maj.or fadors Ihat make it so to canw spre&d. and Some th&awes are ineffeclivè. is tumour hetero9enwty. This characterith cl a tLffiour dexribes ts ¢omplex comp0s￿On with rnany genetic mUta￿On& The key Obje￿￿È lor the fnt sla9e ol this gr￿￿the￿ng research was to devdop a b￿ast caneer m&ael Ihat addresses the issue of htlertsJÈnetty. This has been achieved. and the modd is atready Proving invaluable furthering research in Ihis ehallenging area. For examr4e, the team wa5 able to use tt to disrA7ver which particular rancerous mutats.ons are ￿p￿e of invasion into INer arwj grow Ihere. and vthich a￿ not. It 15 antiC4paled that as this reseafch conbnu•s rt wiu wove ofirnrnense ts￿fil to patients rylh v•10￿ typès (rfcanc8r. Genetic Swhches Since the mapping ol DNA tmth the Human GerKJme Prw( the￿ is 9Wter understanding Wthin the seientift community of some aspects of In Ihe past. the vast maJ"oiity d ONA bdieved to bt 'jw)k' as it tjoes not code lor protein. 11 was thought ￿ a small arno￿1 of was 5¥Jnfficanl. fvt which iums into single stranded RNA, and then into protwns for the str￿Te5 anlf I￿a￿)n$ we are lamitsar wilh Ibrovm hafjr. blue eyes etel. However, ft is now known that muth d DNA is in fact transuibed into non¥codirrfJ R￿As. some of whith play irnportant roles in normal b1¢￿gical function. g￿e re9ulatirm and ￿nCer development. Action Atydinst Cancer i¥ Jnding a rangè of projects rdated to Idents.￿'n9n0n￿jlng ￿￿￿$ that are QFerating as genelic s%wtches causing ¢•n¢er to grvw or s￿IrL￿. EXAMPLE OF PROGRESS.. TLYn Funded by Action Against Cancer, a team led ty Dr Leandro Castellano al The Unr¥ersty of Sussex, 1$ investigating a dass of small RNA mr4Ècules eallÈd miryoRNkn These can ￿￿K)t# a transfmiicm of nofmal edls into cancer ￿115 in 1￿Man bcwth"es. Most microRNAs are p¥oduced in cem5 by zn enzyme ¢d Orn. To sbjty how Chcer reg￿aS ¢ellular transfomial¢on. the team shut down ils expression in cancer cells usiig next-9Èn•ration sequenring. This strategy Simultaneously e￿￿atpA hth¥ nett¥￿$ of gene interacbon5 COOFerate With M￿roRNA$ to promoie catKef prtsyrèssion. By using this approach the team discove￿. the fitst time. that c*-(thredty and independenyy tLvns off the eXPrès￿On of one ol most ￿werful genes. c-ltyo This gene is very diffic￿t to tsrgtt thernpeub¢ty. but Ihese new findirmjs indrale that by modulating Di activity wth chemKal inhibitors, c-myc acbvity be directy lumed off to fi￿t taneer. This is an extremely prom15ing developm￿1 for Pati￿ts.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT) {CONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 De￿￿>Ping a drug for a totslly new appToa¢h kn Ihèrnpy ILMTK31 The K1èntrficalion of a rw ¢arKer caus4)g gene in 3)11 by Pthssor Georgw G￿rna$ was the earf￿$1 significant breaklhrou9h supported by ActTh Against Canw. This gene ralkd LMTK3 is ntht lo humans, and is expressed fflofe th canw ¢dls Ih¢ in norm81 ￿1$. cancer¥ that have hvJh thls of LMTK3 a￿ also muth rn0￿ a99￿$$1¥•. Snce 2011 we have lunded resèarth aining 10 de¥elop w anl￿LMTK3 dn&. Tli5 woulj bè to over￿Me the resistance to Ireatments that often develops v4ilhirt patiènts, bcKlies. Many patsents respond wen to initsal treatfnenl tsjt Ihen develop resistance to il - this is when, with ojtrentfy avallable treatments. their cancer becomes much more to treat. A potential antsLMTK3 drug wiu te sperifically designed to woth in cor¥unction wrfh a patient's ￿$1kng ￿alMent and in a way that overcomes hemolheopy or homional therapy resistance. aifown9 Ihese tfeatsnents to start ¥nrking again. Thi5 would be a M￿ent0￿$ slep in the history ofcanrer trealmenl EXMIPLE OF PROGRESS.. D After yeaTS of devel4Mng LMTK3 speufic t1rugs. the team at the Unp4ersity of &Jssex is now worknng on opts"rnlsing these and tesb.ng them in vityJs modds. They ha%E eslablished ¥J validated differenl types of models for various experiments ar¥J I￿￿￿JaI￿e prcttthres. These Twa te used to ex3mine and clarify the mechanisrn of a¢ts"on ol these novel dftwJ comwunds. In addrfion. how specifKally and effectNely Ihe eompDund$ work lo reduce tumour grtr•Ah w￿11 be lested. TIMS work is crucaal bèfofe pmgressing to thè next preth¢lnical and dinical stages, where the an is to lest the bèst of Ihese dr49$ n patnts. The an￿1pated abAity of LMTK3 in7&Jitors lo overcoff I￿atMert resistance offèrs ènrnus hope for huge numbers of peo￿e. Underntanding the Can￿r Brn is thought that ceJ¢s ha¥e a'brain.. which is reS￿sIb ts tum4)g the 'on' or'oif. ￿ are fundi09 research tO9ain a ccfftprhensNe understanding ofthis cwwbrain. by ￿aMIng exath what lakesplace duiing on$et and 9rTrHth of cancer- one prottin at a lime. Proteins are present in al of the cd15 in body. in car￿r cells. The types of proteins. their quantity. and the level of their adswty can flther between nc￿81 cels and ¢2ncer cels. Prote￿ enable can￿r cells to 9row very fast or Ihey can ¢ausÈ them not to respond to a given drug. One of the main approaches in studying cancer¢ells end idefttfying new Iwlrnent tsrgets i% to analysetheirprotein content in great deta￿. Ath"on Aganst Cantèr sw)porfs researeh to LwK1erstand ¢ancer ￿4$. to the way for the de$4n ol thg$ targeliThJ tho proteins that are fwrvl to play the most irrportant ￿ in ts progression ofcancw. EXAMPLE OF PROGRESS: C By encouraging can￿r célls to Change into normal cdts. diiferentiation It￿apY cgxld offer 3 groundbreaking treatment opt￿n for cancer palienls. It WOLld also redvTr the prot4￿$ of tox￿ ol more conventional Iments such as chemotherapy and radiother4w, tW generally invc4¥È killin9 Iwnour ce115. DrfFerenliation Iherapy is ￿ altemalive Ihat oknate this woblem ￿ the treatment of a¢fvanced cancers. Supported ty Action A￿n$t Cancer. a team has demonstrated h(w4 a speryfic enzyme la type of protein) is involved in ehangln9 brain ￿nCer tels bath into ceus. conknues in exLating area lo futher exarnine this enzyme and its potentsal to hèlp pa￿￿ts.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT) {CONTINUED FOR THE YEAR ENDED 30 SEPTEMBER 2021 P•lela$ts$is lthen can￿r 15 saKI to spwead Ihis means it has metastssised. Thi5 is when cancer ¢e15 break away from where Ihey fitst fomied and travel through fv bk¥yl rx tymphalic systems kn lom) new lumours in other parls of the boty. This development of seo)ndary is ￿lled metaslasis. A metastatic tumour is the Same type of ancer as the wimary bjmow. Ad¥)n Against Cancer funds a nwthr of woiecls that e linked lo ￿derStan￿n9 the causes ol metaslasis, in Order to.. . more effedi¥dy Ihe Ske1￿￿)d cl ce15 rnelaslassiryj (ssyeathgl in each pthnt. . tsilor the tesling for patients with a hwjh fthekhood of tF)w meta51asising SC as Ihe likelihc)d of early thagnosis. . imwoNE the treatrnent slrategkn Iyjr ttEse pati￿ts for metastasis ol trir cancer has EXAMPLE OF PROGRESS. T Triplè negative brèast cartter is often rn0￿ a99re$5pR, metaslasising ffKJre effectivety Ihan olher bmst ￿cers. Action Against Cancer is suppothg research u)to lentsfyty recepttys that sperAfitalty dwi¥e thi8 type of canw, lo be able lo target them and treat pat￿ts. Usffio an innOvab￿ stratègy. the team fThT Klentsfied. for the first lime. that 8 subset cl such molecules is an importanl drivef oltrlple negalNe breast ￿¢¢r and IW these can be used a5 laih)Ted Iherape¢Jtic targets to treal this notoriousty difficutt disease. Ach1ewe￿ts and perfomw￿¢ Oue to the Co¥id pandefflic, Ath"on Aganst Cancers incoffie has ctsthued to be at a muth lower level than durlng prè-pandemic times. A number of I￿￿raI￿ng events or9arMsed by 5VPPOrter5 for Action Against Cancer across Ihe wintry were ￿stp{Thd ry canc4fed. Support from in¢JMduaL8. c¥)mpanies trusts and foundakn.ons was alsosignbficantiy re(bJced. resLlh"ng in less funds raised rèsearch into cancr. However. all at Acti￿ Ag￿st c￿cer e gratefvl to Ilw domrs supwjrtets who were still able 10 donale towards our work. a￿ also extre ol thè weat work the saentists werè abte to c￿ltInUe despite thè many ¢ificults"es Ihw fa￿d. Below is a sample ol p￿iShed p•per$ desoibing pwfy fijnded byAdIC￿ Agafftsl c￿Cer.. 1. ce￿derNed extracelldar be used a$ a t•Jmather reseNoir tor gr￿Las1Oma lurTV subtypin9 2. Breaking through thè 91ieblastoma micrtrenNironrnent ¥ia ex1ra￿lIuI8ryeSldeS 3. The rnultifaceted role ol lemur tyrosine kinase 3 in heamh and disÈase 4. Muftinational landxapes ol norn￿1 t*east thimg age aThY we￿n¢Y ￿teM￿& cancer risk

THE HILARY CRAFT CHARITABLE FOUNDATION UMITED ACTION AGAINST CANCER TRUSTEES, REPORT (INCLUDING DIRECTORS. REPORTI (CONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 Financlal veview During Ihe year the tharitys income ai so￿$ arnounted to £289,334 (2020.. £202.5251. kn the sarn¢ period. expenditure on chartsble acMRs totsmed £1.028,978 12020= £735,594), aTrJ the cosl of raisir¥J fund5 totalled £69.4S912020: £73.7401. Accumulated fvnds as at Xl Septernber2021 lolalled £2.225.OC6 (2020". £3,034.1091. The Trustees consider thal the finanual posrfion as at 30 September 2021 1$ salislactuy. Apprwmatety IWC￿thifds tl Ihèsè lunds (Includirwj lha￿ in uNestrKted fiJThJsl ha been awthed to aFvove(I ￿￿¢ts (set Ncle 131. It is Ihe p0￿cY ol the eharity that uNestitted funds ha%E not been des¥Jnated ftr a specifie use should be rnaintained at a level equNalenl lo belween Ihree and six nw)nths eXpend￿re. The Trustees consider thal reserves at this level wll ensure tha¢ in the ewent of a signifvant diop #i fvnding. they wll te able to continue the harity's current ￿til￿￿e$ ￿nSidera￿)n is given lo ways ￿ vthich additirThl h￿d3 may te raised. This level of reserves has been maintained throughojt Ihe year. Plans forthe lu￿re The charity wil continue lo fvnd 11 d the ryoF¢ls already apwoved. aTrJ to frJThJfaise lo supwt other research ainwng to frKlher understaThJ cav and hryi lo better diagnose aTrJ treat l The tharity wil continue to di55eminate' results ol resea￿1 in wtthshed soenbk on the ¢¥yawisa1￿￿'s wpb>te aThJ in regulw e- newsletters. Structure. gowrnanco and managoment The chafity is a company lirnitetl by guarantee. irwted on 8 Setrteth 2011 aTrJ registered with the Charily Commission 9 SeF4effl￿T 2011. The chwity cwies its acti¥itsts using Ihe workirg narne Action Against Cartw. The Tnjstees, who are also the direct￿ fcrf the of cryny law. and who Sor￿ during th• yèar and up to the date ol si9nalure ofthe fManC￿ 5ts1ements were.. Mrs Miehaela M Rees JLM￿s mault￿ H Craft Mr Jonathan S M Craft Mr Perty eec￿tY Laurence J F Tarfo Hilary S Craft 08E {Deceased 27 De(￿nbel 20201 The Board olTwstèes is aUthe￿sed to aFV)int TnJstees to f• varaMies arisiry the w￿3notion or death ofan ￿StIng Iwstee. None of Ihe Trustees ha$ any benefKial iFwest n Ihe AM of the Trustees are members ofthe company and guarantee lo contribute £1 in thee%enl ofa wnding up. The chaiity benefiis from the ryowsion of attomm¢)Jation administrati4E support from Regency Factor5 P 4 eornpany Ihat is eontrolled by cerlain (4 the Tnjstees of ihe tharrty. No monetary ￿l￿e can be attThtrMJled to Ihis support, and the￿￿e l is not i￿lutsI vi the firwKial stalemènts. There a￿ no other tran￿tiC￿$ wilh related paries. The Tntslees maintsin a register of interesls, whith is upjated at every rrelin9. The Trustees have assessed the major risks towhith the th￿lty is e¥posed. are satisfd that systems are in F4ace to mitig exposurè b the rnaitr rtsks. Intemal control risks a￿ miThmi5ed ty the irrylernentstion of Fcttdures kn aulho￿atiOn of al transactions and PToie¢ts. Procedure3 are in ￿ate to eftswe ilh hèath and safety of slaff. bxlunleers, d￿nts and Msitors.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER TRUSTEES. REPORT (INCLUDING DIRECTORS. REPORT) (CONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 Audilor The aurfrtrffj. Jacson Step1￿ LLP. 15 deemed to ￿ reapp)ini8d ￿der sad￿n 487{21 ofthe Companies Act 2006. Disclosure of inlormation to avdilor Each of Ihe Trustees has confThed that Iherè 15 M infomlabon of whlth Ihey are aware is relevanl to the audit bLrt ofwhich the a￿l￿or is ￿aWare. They have fither confymed Ihal they have taken apFiopri¢ step$ to Èdents'fy SLxh relevanl inforniation and lo e51at&sh that Ihe audrtor ps aware of such irrforrnthn. behaff of the board of I￿￿teeS Mauii¢g H Crnft stee Dated: 29 July 2022

THE HILARY CRAFT CHARITABLE FOUNDATION UMITED ACTION AGAINST CANCER STATEMENT OF TRUSTEES, RESPONSIBIUTIES FOR THE YEAR ENDED 30 SEPTEMBER 2021 The Truste95. who are a￿0 the éiTedots of The Fllary &aft charitab￿ FourKJatrcx) Limited for the purposè of company law. are responsit4e kn preparin9 the TfUSte•s' Repcwt and ihè financial statements in aC￿rdan￿ with applicable law and United King¢Jom A￿)untr9 Standards (Lkntte(l Kirgdom Generalty Accepted AccO￿ling Praciiol. Company Law ￿qui￿ the Tntslees lo prepa￿ finarKiaT slatemenis each fin•nck31 year a true and fair view ol the stsle ol affaws of the tharity and ol the incoming resources and apF4'catw of resources. including the inc4Jmo •xpendiiurn, of th• chaiitat4ecornpanyfor thatyear. ITh weparirvJ th?59 fmancTral statern￿ts. the TnJ5tees are requffed to: . - selecl suilable accounling polcles and Ihen appPy them gxsistenty: . obserye the fflelhods and winuples in the Chth"ès SORP: - make J￿￿9enwts and thal are reasonabte - slate whether applicable ix Accounting S￿dar¢s have been folk)we(l. s￿le(l to any malerial departures disck)sed and explained n Ihe finaTh>￿ slateffl￿ts. - prepare the finanual slaternents the gowy c(K￿rn basis unless it is WRPk¥oprie to presumè that the charity will continue in operat￿. The Trustees 8r¥ respC￿SIt￿e l(* kewng atsquale aCCo￿tir￿> fec£ffds that di8cl)se with ￿a5cffiab￿ accuracy al any time the financial p05itH)n of Ihe charity and erbable them to ensure th3l Ihe financi￿ stalemenls compty with the Companies Act 2006. They a￿ also responsib￿ for safeguarding the assets of the thartty and thenee for taking feasonable steps for the prevention 8fKI dele(aion of fra￿1 and other irrewtslibes

THE HILARY CRAFT CHARrrABLE FOUNDATION LIMITED ACTION AGAINST CANCER INDEPENDENT AUDITOR'S REPORT TO THE TRUSTEES OF THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED Oplnlon ha¥e audited the fin¥￿1¥4 Statern￿t$ of The Fllary Cfaft Charitsble Foundation Lwnited (the 'charitrf) for Ihe year ended 30 SeptÈmbtr 2021 Ythith cornprise Ihe statemènt ol financia ath"wties. the balar￿e sheet. the 5taiemenl of cash flow5 and the notes to the statern￿ts. i￿￿ld1[V4 a surnmy c4 sKJnir￿nt accotsnting policies. The financial reForting Iramehrrt Ihal has appfied sn Ihr preparati￿) is ap￿￿ble law and United K)gdom Accounting Standards. indudry Financial Reptsrting Standard 102 Tho Financial R•￿￿￿"Ag Standord apPI￿able in the UK and Repubk (rfJrelaNI (Uniled Generalty AcceptedAccounting Pradi¢e). In our opinKJn. the financia ststeM￿ts= gbve a Irue and la￿ wew of Ihe state ol Ihe itsilalè compantys affairs as at Xl Septwnber 2021 and ¢f Éts incoming resources and applKation of res(yJrtes. for the year ended.. have been property prepared n acCOrf￿ with Unrted Gujernlly Accepl&J A¢cwnting Practice", and have been prepared in act£{d￿e wilh Ihe rew¥ements ofthe CryaniesAct 20C6. Basls lor oplnlon We conducled our au¢Jit ￿ ￿￿[dance Intemalional Standard5 on Au￿rtTr￿ IUK) IISAS IVK)) and ap￿IC￿) law. Our fesponsits'lities ￿der Ihose standards are described in Ihe Audilofs respons￿"￿tieS lor the audit ol Ihe financial Siatèrn•nts section of OLK rw. We are independent ol the in ￿OrdanCe ith ihe ethic requirements that are ￿levant to our auth"t ol the finaneial statements in Ihe UK inthding the FRC'S Ethical Stsndard. and we have lulfiued ￿Jr olher ell￿7 resp￿S￿lI&1ieS in a¢eordarte Y+ilh these requirernenis. IAÈ bdieve that Ihe audit e￿d￿ce we have oblYAned is suffKient appropriate to prowde a basis opNion. Concluslons rnlath19 to golny concern In auditing Iht ffinancial ststnents, Me have conth¢Jed Ihat thè TNstees' use of the gc¥ng ￿)ncern basis of accounting in the preparation ol ihe finantia sta￿lents is appropriale. Based cm the w)rk we have perfo￿ed. identified any materiat relating to evenis or ¢onditions Ihat, indi¥it1ualty or coNecti¥dy. rnay cast ygniffi¢ant thsubt ihe charity's atsfity to conbnue as a gjing concem for a perbjd of al least twel%E months from vthen Ihe fmancial statements at Jlh)rised issue. Ow reswnSbbifities and Ihe responsib￿llieS of Ihe Tfustees wilh respect tr> going corKem are desryibed in the rel•vant secbons of this reporL Other Inlorniaiion The other inlornation c¢MN)rises Ihe infoffl)akn •) the a)nual other than the finarKxal ststement5 and our auditorfs report Ihereon. The Twstees are ￿[￿Sible fty Ihe oihef infomiabon contained v4ithin the annual Tepcrt CKJr opinion on the financial statema)ts does not wver Ihe olhEr infomiatKJn and. eX￿pt to the extenl 0lhèThvise expltciljy stated in our report. we do ￿t express any kn of assurance condusion Ihereon. Our responsbility is to ￿ad the other infrmalion a￿1. in doin9 so, con*dei whethef the other infomiabon is rnateri8lly lnconsi5tenl￿1h the fmancial statements knO￿e obtained •) the COLKse of the audit. or otherwise appear5 lo be materially rnisslated. If we idenbfy such mat￿131 inconsislenries ￿ apparent rnaterial misstatements. we are requirèd to detem)ine whethef this gives rise to a material misstatement in the fvlancial staternents themselves. If, based on Ihe work we ha￿ perfom)8d. condude Ihat Iherè is a materia misstatement ol Itss other infornation, we a￿ requifed to report that fact. We have ￿1hing lo repcrt in this rwwd. Oplnfons rn olhw matters prts¢nkned by the Companies A¢t 2￿8 In our opinion, based on the undertaken n the course of our aud￿. the infomation wen in the Tru5tee5' report the fmarKial year for the ￿ancIal statements are prepared, whth inchjdes Ihe d1￿CtorS. report prepared kn the purposes ofcompany law. is consistent wlh 1he financial staternents- and the directors. ieport induded theTrustee5' hasbeen prepwed ￿ accordarKe with appk¢abbp1È9al uiraments.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER INDEPENDENT AUDITOR'S REPORT (CONTINUED) TO THE TRUSTEES OF THE HILARY CRAFT CHARITABLE FOUNDATION UMITED atters on 71thi¢h we ave rn4uired to rwirt bytxceplion the light of Ihe knowledge and uNler5taTrJing of the thwity and its enwionmenl oblaine(l in the ￿TSe of Ihe audit. we ha¥e Th)t identified matenal misstalements ￿ the directors. report t•nthin the Trustees. repD the hght of the knowledgè and undslanth& of the eompany and its envKonment obtantd fft the coutse of I audit, we have not identified rnalerial rrMsstalement5 n the Tnjstees. ￿POrt. ￿ have r￿thIng to report in respe￿ of the following matters bn r81alron to whth the Comwies Act 20[￿ requires us to wort to you rf. in OUfOWlllOn. adequate accounting records hwe not ￿tfi kept. or ￿turnS adequate trx au(lil have not been recelved frcffl branches not visited by us.. or the financialslatements are not ￿ agreementwith the ac(y)unting record5 retLwn5". certaindisdosures ollnJstèÈs'iemneratw)n spe(?fied by law arè nol made: we have r￿t obtainttd al th• •offl)ation aTh1 eyglanakn.orts Ihal C¢￿idered necessary pwpose of Jr audrt.. and the Twstees were nol entilled to prepwe Ihe fmnlyal statements in aCC￿danCe with the small companies re9ime and take a(fvantage ofthe small u)mpaniÈs' exemptions in preparing Ihe TFu5tees' report and from the requireffl￿t lo prepa￿ a strate￿ rnporL Responslbililtes of Truste As explained more thjlty in the stattmtnt of Trusl•es' responsibilitses. Ihe TrustÈ8s. who are also ihe rfirectors of thè ch8Fity for ts purp)se of ¢x)mpary law. afe responsiblè for the wepatakn of Ihe finarrial statements and lor being satisfied that Ihey gi¥e a true and ts Ni￿. ￿ lor s￿ intemal control as the Trustees deiermw is necessary lo ènable the preparation of fnancial statemLbnts that are free frorn material mi5StatÈment. whèther due to fraud or error. In preparing the fnanclal statdnents. Ihe Trustees are reSp￿Sible for assessing chaiity's ats￿lty to rmtinue as a going concern. sJisdoyn9. as applicable. rnatteFS related to going concem aTrJ using the 9othg corKern basis of accounb"n9 unless the TnJstees Wther intend to liqU￿at th• charitable company or to ceasè cperalions, or havè no realistic alternative but to do so. Auditor's responslbllities for the audil of the financial slaternents Our objectives arè 10 obtain reascffiabl& assurance about whethèr thè statements as a whole are free frorn material misstaternenl, whether due to fraud or error. and to rsgje an au(lit￿5 report that includes opinion. Reasonable assurance is a high level of assurance bvl is not a guarantee that an auflit conducted in accordance with ISAS WK) will ahvay5 detèct a maten.al nmsstatement when rt exists. Misstatements can arise from traud ¢r error and are considered material if. U￿wid￿ally ¢y ￿ Ihe aggwale. Ihey could reasonabty be e¥pe¢#ed to inflU￿Ce the eccomi¢ decisions of usets taken cffi the basis of th￿ finanrial statements. The extent to whil our pr(Kedwes ¥re ¢8p4e tsf ¢JeWng iwulaithes wKknJirwJ fraud. 15 detailed bebjw. Based on our understanth'n9 of the chaEitab cornparry and sectoi. ¥￿ identified thal ts winupa risks of notF ompliance with laws and regulations rdaled to, but were not Iwnited to. Ihè Companiès Act 2006. the Charities Act 2011, erryloyrnent, pension and health and safety legisLatKin and we cijnsklefed ts extent lo which nor ccfflpliance might have a materialeffect on thefinancial statements. ￿ also Conside￿ those laws and regulations that have a difecl impact ￿ Ihe preparntion cl Ihe financial slatements suth as the Companies Act 20C6 and lh¥ Charilies. Statement of Rec(￿rnended Practice. evaluated mana9ement's incentr¥es and Cfwtwiities for fraudulent marffjulation of Ihe financial statements lincluding the risk of override of cc¥)trols) and deterniined th* th8 pnncyal risk5 were related to managemenl bias accountin9 estirnatès and jud9emeths. 10-

THE HILARY CRAFT CHARrrABLE FOUNDATION LIMITED ACTION AGAINST CANCER INDEPENDENT AUDITOR'S REPORT (CONTINUED) TO THE TRUSTEES OF THE HILARY CRA￿ CHARITABLE FOUNDATION UMITED Our procedures to resF)nd to risks identifd ￿chjded the frJh)wry.' re¥le￿ng Ihe ffnancial stalement dtscb)sures aThJ testin9 to supporiry ¢)r)JnenlatbJn lo assess c>mplixe Ih provi5ion5 of revanl k8ws wuktbjns de5¢rW a5 havin9 a direct effect on the financial staternents: enquiring of managemenl aiKSUt actual and wjtenlial Itb3atw and ¢13wns. their p)kties and p￿￿dureS to prevènt and detectftaud as well aswhéthefthey have knowledge ofany actual. sus￿¢ted or alleged fraud; perforrning anatylKal Pr￿edureS lo thitrfy any unusual or unexpeded relalionships that may ￿dICa(e risks of material misslatement the to fralhl.. reading minules ol meets'ngs ofttr•xe charyed Mlh go¥emance: oblaining an understanding of provisions and hokdin9 discuss￿S wilh managtment b) ￿detsI￿d the basis of reojgnition or n0fvrec0gnrt￿Jn of provi5h)ns'. and in addressing Ihe risk of fraud through managemenlo¥erride of controts= testing the approwiateness of joumal entr¢es: assessing whether the acojunting esl¥nales, judgements and dwsK)ns rnade by managÈmenl a dI￿tr￿e of a polenl>al txas," and evaluating the business rationale of any s￿n1ftant trnnsactions thal are urtu$ual ortytsid¢ Il nom￿1 ¢outse tsf busnwss. We also communicaled relevant hlenttfièd rtguklK)ns and wtential fraud rtsks to all engagement team membws and ￿m8¥￿d alert to any ￿d￿al￿5 of fraud or rorbllojmrkn wth kws and fègulatK)ns throughout the audit. Therè art inhef•nt limitai)ns li audit tA￿edureS ¢knit>ed TIE I￿re rerrthpd that laws and regula¢ipns are frorn fin￿al tr•sa¢tions, Ihe ss &kety it is Ihat e Y￿uld b￿rne aware of non-compliance. Auditing slandards akn limit the authl procedures required to identify nOn-c4)mpkan￿ with Iw5 and regulatlgns to enquiry of the directors antl olhei manwJement the Inspec1K￿ of regulatory and ￿gaI tx)rrèwndÈne¢. rf any. Material misslatements that arise due to fraud harder i¢ dètect Ihan those that arise from error as they may In¥0￿e deliberate Con￿a￿en1 ty ¢￿$Y). A further descr¥>lb)n of resp￿s1￿￿tieS is a4TaAat on the FwiwKial Re￿)rtry Councifs vRtsite al.. htlp5.'11 www.frc.c¥g.uklauditOts￿$P0n&Th1blI•S. desclvlit￿ ofow auditjts repo Use ol our report This report 15 made solety to trE ch¥rttable compan￿$ rnembers. as a bo¢ty. in actordance vAlh Chapter 3 of Part 16 of the CompaniesAct 2006. (Jjr aw1 vKk has underlaken so Ihat we mvJht stste to the chantabfe companls members t￿se rnatters are required lo state to in an auditors. report and for no other purw)se. To the ful￿$1 extent pe￿illed by law. do noi accept or aSSLThe rÈsF￿nSIbllty to anyone other th￿ the charitable cc¥Tr)pany and the charitab c(¥npan￿s mernbe￿ as a tothy. br our wdit wrrfk. tr Ihis repjrt. or for t￿ opinions we have foThr*d. fda4r- Sl4L UP Peter Alkinson F.CA. ISeDiw Statutory Auditor for and on behall of Jackson Stephen LLP 29 Juty 2022 Chartèr•d Accountsnts S1atutoryAurfrtor James House StonKr%)6s Ptyk YewTree Way cheSh￿e WA3 JJD 11

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER STATEMENT OF FINANCIAL ACTIVITIES INCLUDING INCOME AND EXPENDrruRE ACCOUNT FOR THE YEAR ENDED 30 SEP7EMBER 2021 Cvrrentfwtancial y•ar Total To fvnd5 2021 fvnds 2021 2021 2020 Notes Vdunlaiy in￿$me In¥estrrnts 226.039 9.628 279. 9.628 175,040 27.485 Totsl incom• 235.667 S3,667 289.334 202.S25 endithre ow. Ra5ing fijnds 69,4S9 69,459 73.740 Charitable actsvities 1.013.959 1S.019 1.028.978 735.594 Total 1.083.418 15.019 1.098.437 809.334 Net lexpenditureifincome for the yearl (847.751) 38,648 {809.1031 16C6.8091 Fund balances at i O¢tober 2020 2.959.607 74.502 3.034.109 3,640,918 Fvnd balan¢•s at 30 S•pt•mb•r 2021 2.111.856 113.150 2.225,(￿ 3.034.109 Th• stalement of financial zetibibes incknjes a¥ pn5 * Io55es recognised in Ihe y￿. l and expe￿￿rture C￿li￿1n9 xb¥its. Thè statemènt of financial ￿ alsts with the rewyemerts for an income and eX￿￿ule attount under the Companies Ad 20(*. -12-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER STATEMENT OF FINANCIAL ACTMTIES (CONTINUED) INCLUDING INCOME AND EXPENDITURE ACCOUNT FOR THE YEAR ENDED 30 SEPTEAIBER 2021 Piior finawKIBly•ar UN•strictsd Restrlcted fvnd$ funds 2020 2Q20 Total 2020 Notes Income from.. Voluntsry Investments 1￿,021 27.485 1S.019 175.040 27,485 Total income 187.9J6 15.019 202.525 •ndl Raisin9 fund5 73.740 73.740 Charitable ac11v￿•S 702,751 32,843 735.594 Total 776.491 32.843 809.334 N•t l•xp•nditvrnifincom• forthe y•arl Net movement Sn funds 1588.985) 117.8241 1606.8091 Fund balarKes at 1 Othter2019 3,548.592 92,326 3.640.918 Fund balances at 30 Sepl£mber 2020 2.959.￿7 74.￿2 3,034,109 The slaternent of financial ¥cb¥ities indudes all gains and ￿)sSeS le￿gnIsed in the ￿r. All income and expenditwe deri4• from contiN•vJ acbwiS. The slaterrent of finanryal adi¥ilies 0 T•rilh th• ￿￿￿Ten￿nts br w irKomt and expenditLtre a¢count under the Cornpanies Acl 2(￿. 13-

THE HILARY CRAFf CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER BALANCE SHEET AS Af 30 SEPTEMBER 2021 zo 2020 Current assets l)eblors Cash al b8nk hand 10 381 2,302.991 381 3.133.361 2.303.3rd 3,133.742 Creditors". amounts fallng du• Tlth on• y•ar 11 (T8.3661 199.6331 Nei cuffent assets 2225,1))6 3.034.109 Funds of the eharfty Restricted funds UnrestrKled tund5.' General unrestrithd fiJrLd$ Designated funds 12 113.19) 74.502 641.9)3 1,469.953 431,359 2.528,248 13 222S.¢X6 3.034,109 The fnanrial stslemenl$ wwe apkYobd ty the TnJste&s on 29 J￿Y 2￿22 r Mauricè H Craft Company Registration Nty 0776724 -14-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER STATEMENT OF CASH FLOWS FOR THE YEAR ENDED 30 SEPTEMBER 2021 2021 2020 Cash Ilows operntin9 a¢li¥itles Cash absoibed by OF¢rat￿n$ 16 1839,998) 1587.6261 In¥estln9 actlvities Investmert income recÈi¥ 9.628 27.485 Ntt ¢ash 9enernted fr(Yn Invesllng activitiès 27,485 N•t cash us•d In flnandng actlvltles Mel de¢rpase in cash and cash ¢4ui¥alents {830.370} 1560.1411 Cash eguWa￿￿1s al b8ginrrirvJ of JE 3.133,361 3,693.502 Cash and rAsh equlvalents at end ol yèar 2,302.991 3.133,361 15-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMrrED ACTION AGAINST CANCER NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 SEPTEMBER 2021 Accounting polkies Charlty lTrfornMtlon The Hilary Craft Charitth Foundaiicffi bmited is a wwate company knited by guarantee itorporaled Engl￿d )d and a (ègtste￿d charity ond IAs. The reWred olke L$ 2 RegerKy Chamber5. Jublee Way. Bury. Lanra5hire. BL9 (klw. 1.1 Accounting eon¥entSon The financial Stslements teen prepared in 3cccdance ilh ts chaiity$ goveming drKumenl, Ihe Comwies Acl 20C% "ACcoUntw￿ Reprykng by Chaiitss.. Statement of Recommended Practice applicable to chant5 prepamg their accounts in aC￿r￿M with Ihe F￿ancial Reporting Slandard appltcabte in the UK and Repuknl￿ of Ireland IFRS 102)" (as amended for accoLmting periods ¢￿￿en￿n9 frorn 1 January 2016). The tharity is • Put Benefft Entiy as defmed by FRS 102. The fmanual $latements are prewed in $terfYy, is fWKlic￿ the charity. m￿etary amounts ) these finial ststements rowthd to the ntartst £. The financial stslemenis have wE￿Ied the historical ￿1￿1 ¢￿11￿. Thè prvicipal acCO￿tirbg ' pc4ia•s adopted e set wt tqhy. 1.2 Going concern Al the tirne of approwg the finwKial stalements despite the effect of Co¥id-19, the Tntstees have reasonable expeetsticffi thal the chity has adtquate resources to continue li operabonal existerte fe¢ the foreseeable future. Thus Ihe Tn&stees to adLW the goin9 cwKem ba515 of acc(MJntWkg in wepwin9 thè financial statemènts. 1.3 Charit•b funds Unrestricied knds • WdrfaLqt fty use at the thcre1lL￿ of th• Tntstees in furlheranc of Ihew chiabl8 objecb¥es. Restrict&d funds are svbpct to speak cc¥)thtic¥ts ty donors as io how Ihey may te used. ThÈ purposes and uses of Ihe reslrited ILThJs are set the notes to ihè &CL￿nts. 1.4 Income come is recognised thanty is legally enblled kn it after any perforrnarte ￿nth￿on5 have been mèt. the ancyjnls te measured ￿￿"abty. probat4È Ihatincome be re￿Ned. Cash dwat1￿$ ore re￿gnIsed ￿ receipL Other drwlions are rwnised ￿ce fv tharity has been notif￿d of the donatic¥). ￿lesS pertornianc• cefiditi.ons fequwe defewral of Ihe amount Income recoverable in lation to donatrons rec2r￿d ijnder GiftAid or d￿d5 of covenant is recogTh5ed at the time ofthe dcffiation. Legac￿ are recognised receipt or otheNin rf chawity has been notifièd of an Thpendng distributi￿. the amtsJnt is known. and we•yt is expected. If is not knovffi. Ihe le9acy is treated as ¢ontingent asset. Donaled are recogn¢5ed as incwne when Ihe chwity has c(mtrol over the item. any Condit￿)nS associafed with ts itern have been MÈL the reteipt cl the economK b￿erit fr(Mn the use by the charity of the item ¢ probable and tl eetsntth￿ benefft can te reliat+y. On rectpt. dcnated semces are rtcognised ￿ Ihe bas￿ of vabje cl Ihe gift to lh¢ charty Wh￿ is lh• ount the tharty W1￿1d te ￿lig to FOY to oblain ser¥ices ￿ fxiliiies of equwatent economic benefrt on the open mafket: a correspondw)g ¥ffio￿t Is recognis8d i) expendrturè n the peri(MJ of racèyL 16-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER NOTES TO THE FINANCIAL STATEMENTS {CONTINUED) FOR THE YEAR EPIDED 30 SEPTEMBER 2021 AccouDling policies ICoTrts"nuedl 1.5 Expendilure Expenditure is rec￿lsed the ac(¥uaLs basi& Fundraising costs we those inojrred n genera¥9 fi￿d$ th) not In¢￿de ts rg)sis of dbssemin81ing information in support of the chariiatle actr4itss. Swjort we those ￿st incurrèd (lirtdly in support d expenditLYÈ olthÈ obs•ets olthe charity. Overtp¥d costs area1r￿aIed w the basis of the •du.spend ty aclivity. 1A Cash and cash equivalents Cash and eash equwalents indude cash in hand. deposits hehj al call with banks. olher 5hort-term liwid investrnents wlh original malurrfies ol th1è8 ￿￿th$ C￿ less. bank ovwdralts. Bank o¥erthafts are shown within bmwings ￿ ￿[re￿Il￿b￿￿e$. 1.7 Financlal Instruments Thè eharity has ele(xèd to aprly the pr￿￿$ of Sedion 11 'Bast Financial trtslruments. and Section 12 'Othw Financial Instruments Is5ue5'0fFRS 102 10 01 of its instrum￿1$. Flnaxial 1nstwwn￿ts 00 rettwised i) the bolart¢e sheet Tkn ￿ charty becomes party to the Contractual pmwsths of thè )strLThent FinancKAI assets and liabilitie5 we offset. wilh the net amount5 wesented n the fnanekal statemthts. when there is a legally enforceable rwjhl to set off the recowised arno￿t￿ and there is ￿ ntenb.on to settle on a nel basis tsrto reah'se the a55el 5etUe the SIm￿lane9v￿. asle finaneialassets Basic f￿anCial assèts, debtors cash ant1 bank balan￿s. a￿ measured at transaclion price indu¢&)g transac￿"￿ costs We St￿Se￿en￿ caryi8d at amorbsed ¢))sl ugrg th• effective interest method unless ihe aryangement constitutes a financing transactk)n. there the transaclion measured at Ihe wes&it waJe of the fulwe receip15 disc4JW4ted at a market rate of inleresl. Financial assets dassified as receiv￿le within oneyear are not armwlised. L>erecognltkn olllnanc1al&￿ets Financial assets are t1erecogned then the (a)ntracbJal rvjhts to the cash IIN5 from the asset expl￿ or are settled. or wh)en Ihè thaiity tsansfefs the finanoal as5el and SLbstantia#y all the risks and rewafds of ownership lo anolher entity. tr rf some signfftanl rtsks and rewards of omefshp are retained but Control of the asset has transferred to anothw party tr￿1 1$ able to sew the assel n rts ￿)ti￿ty to an unfelated third party. Baslc financialliabllits•s Basic financial IptsI￿e5. induthg L¥etht￿ and bank loans are inknaly reragnised ai transaetith price unless Ihe arrangement constrtutes a financing transaction. the debt instrument is measured at the present value of the futurè payments ¢Jiscounted at a market rate of mterest. FinancAal liabilrt￿s classffied as payable thin one yearare not am(xiised. Debl instruments we s￿Se$￿• cwried at ￿rtISed c051. usv4 ihe ellecknp mlwes"t ratè Trad¢ ereditors are cAigalK)ns to pay for gC￿￿5 ar servrys that have been acwwed ￿ IPie ￿dInary course of operations from suppliers. Amounts payable are das5ifd as ujrrenl liabl1t￿5 if payment 15 due 7Mlhin cffie year or less. If not, they are presented as n￿-c￿Tent liablrt*s. Trade ￿drtw$ We reo)9nised Tr)ilially at IransaiXv)n p￿e and $￿Se(￿le￿IlY measty￿ •t #m￿lsed i))St uwg ts eifecirrt ittwest metho 17-

THE HILARY CRAFf CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER NOTES TO THE FINANCIAL STATEMENTS ICONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 Accounting poli¢s IConllnu•dJ Dernc0gJie￿ olfinan¢Il￿bllffts Financial Iiabth.t￿ are threcoJni5ed the ctsiitys ethitraclual otAigabons expffe or arè distharged or cancklled. 1.8 Employee b•nèffts Thè eost of any unustd hotday ￿trt￿)ent is re￿￿1￿1 in the thè èmpkJeÈ's servi￿$ recer¥ed. Ttrmnation benefits art recognised inèdkatety as ￿ expense when thè charity is demonstrabty thmmitttd to lenninafe Ihe employment of an empbyee ￿ to provJe terminakn tenefrts. 1.9 Retirement benefits Payments to defined contr+￿ retsementbenefft scknies a￿ ￿￿19ed as an expense as they trdll du8. Ctitital aceouirtlng stBhtes and V￿g￿ne￿ts In Ihe application ol the charitys accOunt￿g polws. the trustees are requi￿ to make judgements, egtwnates and assumptths a￿)(rt the carrwng amount of assels and tAbilrties that are not iea¢Jity apparent from olher sowces. The estimate$ and asscns kn 8¢¢cxJntiny estsmates are ￿cOgnISed ￿ the perk)d in whmth ts eslimatè is revised where the revision affects onty that perir)d, or in thè pèrb)d of Ihe s•¥iS￿ and fuiur& per￿ the revis#)n affects both curr￿1 and lulurg wJd5. Th• lrnstees consider there t t* rKJ crdKal acts)LTh)kng estwrAtes orwdgements math. Voluntsry Incorne Tolal Unrestricted RestrKted hJnds funtjs Toial fun(ts lunds 2021 2021 2(121 2020 2020 2020 Donalb)n5 and gift$ Fundr¥1$￿9 events 218,494 7.545 52.$45 1,122 271.039 8.&$7 159.116 15.019 174.135 905 226.039 53.667 279.7( 160.021 15.019 17S.040 18-

THE HILARY CRAFf CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER NOTES TO THE FINANCIAL STATEMENTS {CONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 Inv¢$tsints Ilnreslrkted UnrestrKted funds lunds 2021 2020 Bank acts￿nt s￿tth incenlr Interest receiat4e 6.563 20.922 9.828 9.628 27.485 R•ising funds Unrestricted Unr¢stri¢ted fitnds fijnds 2021 2020 Costs of generalwig ¥￿Ur￿ Tra%llin9 and subSiste￿e Prinlin9. stat￿nery and Fisi Fundraising •x￿nSeS other •xp•ns•s Advertising Other fundraislng costs Staff costs Insur8n¢e 1.130 1,25S 536 85 834 272 68.545 177 445 66.594 C05tsof generating wluntary incomè 89.459 73,740 19-

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 Chaiitabl• a¢liviti•s UftrnstrlclÈd ftè5trKted 2021 2021 Total 2021 2020 LMTK3 di￿ develwThent Under51anding the cancw bw¥ PhD and olher sttjdert ￿r$8￿$ ljvafian ¢ancer research Panueakn"¢ ran¢¢r ￿$¢arth Cancer slem cells researth Genetic swilthes asl caneer ￿$t￿￿ Olher reswch syoied 308.789 XQ.789 124.039 21,835 60,595 19.870 S6.332 23.569 129,136 279,117 16.310 99,393 99,393 23.C64 14.808 14.808 134.S08 428.075 232 134.YJ8 443.094 232 15.019 1.TrJ8.89) 15.019 1.023.918 730.803 Shar of govtmanee casts (set rK>t 7) 4.791 1.013.959 15.019 1.028,978 735,594 Anatysls by fund Unrestricted funds RestrKted fiJ)ds 1.013.959 1,013.959 15,019 702.751 32.843 15.019 1.013.9S9 15.019 1.028.978 735,594 T.h• other r•s•th woj•d is mairty li relatbjn to on ttffnour rniuomanagement. Support Costs Support Governance co$ts 2021 Swport costs Governance cosis 2020 Audit fee5 Bank chargès ProfessKJnal fees 4.050 4,OSO 483 258 727 283 727 283 2S8 4.791 4,791 Anatysed between Charitable aclr¥ities 4.791 4.791 Governance cos15 inthde £4,050 12020.. £4.0501 in fektbjn to aLJit fees payabk to Ihe audor. Thèsè services were donated by the audrtN hen¢e e i￿￿lded within vobJiW income.

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER. NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 Tntstèes Ncfft of Truste•s (or ary ￿r$on$ connected rylh Ihèrn) receivtd any rernunernticm or beneffits the carity duriTrJ Ihe year. A dose famly member cl a truslee VAS remw*rabJ for adm￿lstraINe ser¥ice5 owded in Ihe year t0￿ing £15.OQJ12020'. £15.OCQI. Th• avera9e monthly rnJmberemFrfoyees du￿n9 kne year was: 2021 lkniber 2020 Mumber Management EmployThent co¥lS 2021 2020 Wages and salaries Social security costs Olhei pension costs 62.720 2.591 1.283 63.425 3,831 1.289 66.594 68.545 No 8mFloyees had anrvJal remuneration of£e0.0￿ or more. Many of the research Prohth use of P￿0 stswJ•nts. Acli¢ffi Against CarKer is ￿ffenty f￿)(￿ng a nwnber of PhD stud￿tshIpS ar¥J fe1kY￿h¥￿ al Irwizl Cdle9e * support the re¥earth work. 10 Debto 2021 2020 Amounts falling due"within one ye•r. Prepayments and acuueil iwKome 381 381 11 Credltors: amounts f•lkng due wilhin one y 2021 2020 Trwje ¢reth"Icf OthèrcreditCrf5 Ib.110 1.558 yi.¥yy 78,366 99.633 -21

THE HILARY CRAFT CHARrrABLE FOUNDATION LIMITED ACTION AGAINST CANCER NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 30 SEPTEMBER 2021 12 R•stri¢lod funds The income fvnds of ts chanty indude reslrthd ItThls conytsing the unexpended balance5 of natN)ns and ￿ tEbJ w typJs1 ts ¥ec purposes: PAo¥ement in lund$ &)¥ement in fund5 1 Cti•b•r2019 1 Ixtrjlw 1020 30 Septefflber 2021 Can￿[ stwn cels fesearch Genebc switches ast research 83.052 (23.569> 59.483 53.667 113.150 9,274 {9274> 15,019 15,019 (15.019) 2.326 15.019 132,843} 74.502 53.867 115.019) 113.150 The resewth wryk teww uThkrtaken 15 desue(l in d2lail in Ihe Trustees. Rep¢Jt uThJ ReSe￿h Then& 13 Deslgnated funts Out of the lolal funds d £2,225.1))6 availabIe. i￿4uding Lmrestrthd ￿Me. funds have been awarded lo approved pfoieets planned fijlwe expnditure or the ￿xI iwo years is cahwlated to t £1.583.103. Of this. £113,150 are re5trKted frjnds and É1.489,953 we unrestricted funds. Desi9naled fvnds awded to pripcls research Ihemes sMwn li the ta￿￿ tekm. Pfogramrne area Genelic Switche5 LMTK3 CSCS UCB Melasla51S Tolal nds desiwal 229.972.37 835,699.03 375.851.76 34,527.05 107,052.82 1.583.103.03 stiiclEd hrstrictsd 229,972.37 834.199.03 264.201.76 34.527.05 107,052.82 1.469,953￿3 14.53 2.79 3.74 .18 .76 1.500.00 111,650.00 113.150.00

THE HILARY CRAFT CHARITABLE FOUNDATION LIMITED ACTION AGAINST CANCER NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) FOR THE YEAR ENDED 30 SEPTEhl8ER 2021 14 An$is ol nètassets betsweèn lunds Unrestricted Restrtcted lunds funds 20 2021 Tolal Unreslrwled Restricted funds funds 2020 2020 Total 2021 2020 F￿d balances at 30 September 2021 are p￿sented by.. Current asset￿{￿aN￿￿$j 2.111,8 113.19) 2225,IX 2.959.807 74.502 3.034.109 2,111.856 "113.150 2.225.OC6 2.959,607 74.502 3.034.109 15 R•lat•d party transadion5 Olher th 8$ di$cb)sed in NAe 8. there wwe Tr) ifjs()sable ried partytran5aLicffls durkng Ihe year P020 . norel. 16 Cash generated from operatt¢x 2021 2020 DefKal for ihe year 18C6.1031 I6[￿.809) Adjustm•nts lor. In￿$t￿ent ineome rewJnised in Ststern￿t acNitkS 19.6281 (27.485) Movements inworking capital". IDeueasellin¢rease ) ¢yeditors 121.2671 46,tr)8 Cash absorbed by 0￿ratIOnS 1839.81 {587,6261 17 Analysrs of ¢hange$ In net lunds The charity hJ no debt durng the ye.