STMARK5
H O S P l T A L
FOUNDATION
A Future Free From The
Fear Of Bowel Disease
ST MARK'S HOSPITAL FOUNDATIW 2023
TRUSTEES. REPORT AND FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31ST MARCH 2023
CHARITY NUMBER: 1140930
COMPANY NUMBER: 07532184

ST MARK'S HOSPITAL FOUNDATION
S, MA%AS
Front
* I

ST MARK'S HOSPITAL FOUNDATION
Contents
Pag•
Trustso8' Report
Chaimian's Statement
Govemance and Management
Risk and Intemal Control
Obj8ctives and Activities for the Public Benefft
Achievements and ActiVi￿S 2021-2022:
Research
Education
Financial R8W8W
Statement of Trustees. Responsibilities
Indopendent Auditors, Report
Statement of Financial Actlvltlo•
Balane• She•t
Stat•ment of Cash Flows
Notes to the Accounts
Reference and Adminlstratlv• Infomiallon
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19
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ST MARICS HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 315T MARCH 2023
chai￿an.$ Statement
St Mark's Hospital ¢onllnued lo establish itsetf at the new main ￿te al Centrdl Middlesex. From a clinical delivery
point of view, l am extremely proud of the St Mark's clinical team as they continue to deliver théir specialist care
for patients referred nationally as wo11 as wor￿ng lo meet the demarKls frcrfn an ever-increasing number of
referred patients from within its geographical area.
The St Mark's Hospital Foundal*)n and its staff are now fully embedded at the new sile wherg their acttvitses lo
support research and education are now almost exclusively delivered. Although most of our research felk)ws are
now based there, we sb"Il have fellows on dinical rotations at Northwick Park. which is the acute hub of the NHS
Tiusl that Sl Mark's is part of. Our research collaborations have grown further this y88r with several new projects
working wilh other healthcare and rgséarch cenlres nationally and inlemationally.
TDlal income for the year wa5 £2.648,831 whilst total expenditure for the year wa$ £2.273.324.
Total income increased by 54% when compared ￿th previous year's ino)me of £1,722,853. mainly du6 to an
increas8 in legacy donations and education income Fundralslng for restricted researth prolects raised
£1,283.208 which was an Increase of 32% at￿ve last year's income of £970.278. Academic income continues lo
grow year on year and this yaar's income of £5C6.445 was 60% higher than last year. Sponsorship and ￿Urse
delegate income continues lo grow strongly, malnly due to supp)rt of the sponsors of our in-pgrson and
hybrid courses. The annual Frontiers conference in November 2022 saw our first ever synchronous hybrld
cours8 with 150 del6gates attending in person 88¢h day at Glaziers Hall, and over 2.OCrf) attending online.
Totsl expenditure was highor by 23% rgflecling an incr83se in spend on r8soarch proj•¢ls as w811 as higher
oducation costs because ol our growing course prograrnme in¢luding a more substantial Fronts6rs cx)nference.
Thg ¢OSt of raising funds as a percentage ol lolal expgndilure remained the 5am0 as th6 previous year, at 10%.
l am pleased lo report Ihal the Foundatlon's unrestricted reserves continue lo maintain a healthy level at
£862.196 whlch is equivalent to just under 12 months of total unreslricled expenditure. In addition. the
Foundallon also hjlds a healthy balance of designatod funds 01 £558,694 and restricted research fvnds of
£2,858,645.
l am particularly proud of the outcomes of signrfi¢ant research proiects durfng Ihls year that the Foundalion
has supported over Ihg years. Their impacts were particaJlarfy felt during Ihis peric#l. As a direct result of the initial
funding provided by the Foundation for the cok)reclal ROBOTIC SURGERY programme, the benefits of using
robolic laparoscopy for colorectal and anorectal surgery We￿ demonslraled. In eady 2023 Ihe NHS Trust began
the process of purchasing three more surgical rotrK)Is. The funding of the CTC PERFECTS project proved thal
with the dghl type of training. radiologists and radiographafs could stqnifieanlly increase Ihe detection rale of
polyps using a CT scan. This now has béen dèveloped further with a grant from NHS England which is
8UPPOrting th& role OLrt of a national CTC accredrtation programme uslrwj the inspJhts arKI data from our
PERFECTS research project.
We hosted a very successful event for supporters of the Fou￿1a1]0n at Glaziers Hall on one of tha evenings
during the Frontiers conference. This enabled our supporters lo hèar about Ihe lalesl actiMlie5 of th8 FoundatSon
and the wlder hospital bul al the same lime. k8pI c05t5 d¢Jwn. since the venue had already bean paid for.
As the hospital now builds its speaalist services further at the new Central MIdd￿SeX sile. Ihere are more
opportunities for the Foundation lo support the improvements in the faalilies lor education and wsearch,
including for the new endoscopy cenlre. We are calliThJ this opportunity endoscopy+
On t*half of the TnJstee Boar(J and management team, I would like to thank the FourKlotion staff and all our
existing and new donors and supporters for their ￿mM[IMent and contributions.
Sir Thomas TroutsTidg8
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ST MARK'S HOSPITAL FOUNDATION
TRUSTEES, REPORT FOR THE YEAR ENDED 31ST MARCH 2023
Th9 Trustees present their r8POrt and the audited finanaol statements for the year ended 3151 March 2023. St
ark's Hospital Foundalton is a company limited by guarantee, incorwrated on 16th February 2011 and not
having a share Gaprtal. It was registered as a charity with the Charity CommissDn for England and Wales on 2
March 2011. The Foundatson comm8nced operab'ons on 1° April 2011. when th8 assets and operations of Sl
ark's Hospital Foundation Trust. a charity registered with the Charity Commisslon for England and Wales under
Charty Number 1088179, were transferred to the corporate charity. The Foundation is operating under ex￿tlY
the same pri￿lpIe and objects as the unincofporaled Tnjsl and continues lo support Sl Mat1('s Hospital.
particularly by funding resea¥ch projects, as well as managing and deliverrng a large programme of educalon.
enabllng the dissemination of b051 practice in Ihe field of bowel disease al St IAark'$ Hospit81.
Governance and Management
incIL￿dIng appointment of th8 Auditors. Monthty
managemenl accounls are provid&d lo tho
Trustees. giving infornation on income and
expenditure and bu(Jgel comparisons.
Trustees are appointed by Ordinary ResolulK)n or
by a simple majority of all the Trustees enlilled to
attend and vole al any meeting of Ihe Tru51ees.
Trustees hokl offlce until th8 end of the fitsl
meeting of the Trustees following the third
anniversary of appointment or reapwintment.
Trustees are pemiitled lo stand for re4leclion for
further tsvo terms with duration of three years each.
Amongst the Trustees Ihere is a good mix of skills
wlth both medical and non-medical representstives
bringing me(lical, busln6ss and financial expertise
lo the Board. Thwe 1$ also di¥er¥ity of gender and
age.
Fundralslng Commltt•o
This consists of the Chaimian {Truste81, two
Tru$lo9s. ts CEO 8nd Fundraising Manager.
The role of the Fundraising Committee is lo pro￿de
oveT¥HJhl of tho a￿l￿ts'e5 of the fundraising team.
and lo ensure that fundr8islng actiwty is in
accordance with the 51raleglc goals of the Board of
Trustees. The Committee is the key condult for
0)mmuni￿tion and reporting ba￿een the
lundraising team and the Board.
The Board of Trustees 8dminlsters St Mark.
Hospltal Foundation, meeting quarterfy. The day-ttr Rowrch Ovèrnlght Comrnltt••
day operations of the Foundation are managed by
Thls ¢ommtitee does not have any direct Truste8
th& CEO. who ￿pOrtS lo the 8oard on perfomiance
represenial￿n. 11 consists of the Dean of the
against Ihe 51ralegic plans approved by the
Academic Inslilule. Ihe Cllnical Dlreclor of Sl
Truslees al quarterly meetings, when reports from
Mark's Hospital. senior ¢onsultants, and tha CEO of
th8 Clinical Director and the Dean of the Academlc
the Foundation. Tho Committee reviews all
Instllute are al80 re¢eived.
proposals for TeseaTch Projects and approves Ihose
that meet It* criteria of Ihe hospital. Funds are
raised for the approved proje¢ts in order of
pnority sel by the c>)mmitt88.
The Trustees do not ffj¢eive remunoral￿th or deriv8
any other personal bengfil Irom Ihe actiwtss of the
Foundation.
The Trustees may delegate any of their powers to a
committe6 cnnsisling of ￿ or more Tru$lees. The
followlng committees have been estsblished:
Rlsk and Intornal Control
The Truslegs have overall responsibilty for
ensuring tt)al the Foundation has an 8ppropnate
system of intemal controls, financial and othérwise.
They are als9 responsible lor safeguarding the
assets of the Foundation and hence for taking
reasonable steps for the preventh'on and detection
of fraud and other irregularities and lo provkle
reassurance that
Flnance and Audit Commltt
This consists of the Chaimian IT￿￿te&l. Treasurer
ITrus18el, CEO and AC(￿Untant.
Expenditure is sup8rviseA by tha Committ88 to
ensuw compliance wrth decisions taken by the
Board of Trustees. The Committee presents the
draft annual budget to the Board. oversees the
performance of investments, helps to idenlfy.
evaluale and manag9 risks and oversees the
effectiveness of the Foundakn"on's external audit.
its assets are Safeguarded against unauthorised
use or disposthn..
P&ge 5

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 31ST MARCH 2023 (continuedl
proper records are maintsined. and financial
informatson used within the FOundat￿n or for
publication is reliable- and
the Foundation complies wilh releTrrant Ws and
regulations.
rrfeiving upd81es during the year on Gurronl
research,. and
rec8iwThJ updates during the year on
postgraduate education.
The above enables the Truste8S to sallsfy
As part of the Foundation's risk managemont
themselves thal the Foundation wlicies ar8 being
process, the Trustees acknowledge their
implemented. that swJnifi¢anl weaknesses of control
responsibilty for the Foundation's system of
idenbfied arg baing promptly addressed and on Ihe
inlemal controls and reviewing Ils effectiveness. It
overall adequacy and effectsven9s5 of thè
IS also recognised by the Trustees that such a
Foundation's systom of inlamal control and risk
system is designed lo manage rather than eliminate managemenL
the risk of failure lo achieve Ihe Foundation's
objectives and can only provide reasonab￿, not
absolute, r8assuranc8 agalnsl malerial
misslatemenl or loss.
Objectlvas and Activltles for the Publlc
Benefit
In lin• wllh the Charity Commission's guidelines on
The objects of the Foundation, as set out in the
sk management. thè Fwndation has developed a
Articles of Association, are reslrictad specifically to
risk register. oullSning the potential iisks th6
the promots'on of research into and education in
Foundation could face, weighing Ihe likelihood and
disordèts of tha gastro-inleslinol Irad and pelvlc
potential impact of each and tho current and
floor. The p)licy adopted is to provhle support for
research al Si Mark's Hospital. by making grants for
proposed actions r¢qLbired lo mitigate those risks as research projects approved by the Board of
appropriate. The most sKJnrficanl risks for th•
Foundation Include..
Trustees. ond lo fund the Academic Inslilule'$
its ability lo fundraise sufficient unr8stricted
po$tgradual8 courses and le¢lures and tha
Income to COV8r core ¢osls and lo generate a
observation of surgical procedu￿$ al Sl Mark's
surplus lor Trustees lo designate for re$¢arch
Hosprtal for medi¢al Students from around the workl.
and educalion:
the length of lime from receipt of furKling to
rosearch project completion.
A Multkmedla Department, funded by th8
Foundation. Is a valuable ￿sOurce provldlng support
for both research and aducalion vllhln Sl Mark's
H¢)8pitsI.
The Trusleas minlmise risk lo the Foundation by..
monitoring the risks by Teviewing the risk
r¢glstar on a regular basis..
setting a policy on eKwTrJilur6 aprxoval,
signing of cheques arbd the authr￿saIion of
onlin8 banking transactions;
holding regular Trustee M8elings',
holding a Chanty Care insurance pollcy with
QBE UK Ltd.
recèiving monthly management ac0￿nts
comparing activty agalnsl budget;
The Trustees refer to the guidance contained in the
Charity Commis5i0n g&ner81 guidance on public
benefit when roviewing the aims and objectives and
in planning future activiligs. In particular, the
Trustees consider how pknned activities will
conlribule lo the aims and objectives that have bgen
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ST MARK'S HOSPITAL FOUNDATION
TRUSTEES, REPORT FOR THE YEAR ENDED 31ST MARCH 2023 Icontlnued)
Achievements and Actlvltlas 2022-23:
Overvièw
St Mark's Hospital Foundation r8 (Ipdi¢aled to fundlng medical research al Sl Mark's Hospital that driv05
clinical improvoments and in¢rgases the Unde￿tandIng of complex tM)wel diseases. The Foundation also
operationally facilitates the delivery of an extensive programme of oducation and income-generaling
courses (both physical and wrtuall through the Sl Mark's A¢adgmi¢ Institute. These are delivered by the
dinical staff al Sl Mark'5 Hospital to doths and other healthcare professionals who attend in-per50n
and virtually from across the globe.
The 2022-23 financial year slartod strongly as many of our researchers published and presonted papers
al gaslroenlerology and Surgical ¢onf6rénces nalK)nally and inlemationally. Some of our existing
strategic research projects in eady carKer detection and In￿vationS in endoscopy aThJ surgery
developed further into NHS adoplion. W8 also began lo support new projects into personalised treatment
pathways for patients with innammalory bowel disease.
Two of our most slgnlflcanl aChIe￿MentS evidenced the valuo of our earfy-stage funding of research
Inltiatlves. Following the success of the robotic surgery programme. most Sl Mark's surgeons now use
the robot for many of their surgerles. SUrge￿s from acmss the Tn￿t in other speci811ie$ are also
requesting a¢¢es$ lo surgical robots and the Trust is planning lo purchase al least more robots.
Our re¥eaTch into polyp detection using CT scans has led lo an NHS Engl8nd gT8nt10 8UPFQrt th8 rol8
out of a national aCC￿￿1(all0n program￿￿ for CT Cotonography.
Th¢ number of dlnical observers from abroad now exceeds the pre pandgmic levels and we also
delivered more and larger courses than the year b6lore in our educatlon programme.
Somo ol our key achievements ol Ihe year were:
Our largesl and most successful Frontier$ ¢onferen¢e in lemis of numbers of debgales. th6
nsi$lenl positive delegate feedback, and the ino)me from sponsorship
The estsblishmenl of the national accreditation programme for CTC Colonography
Proving the case for wider adoption of robotic surgery acro55 our NHS Trust
Ngw funding for research into earlier canw d8teclion lor higher risk patients
Growing our income and research spend whilst also maintslning o high bv61 of reserves
Despite contlnued and well documented challenges within the NHS. our pr(*3rammes of research and
education have continued lo grow and dev8bp very well in the last 12 mc¥)ths. The Board is confident
that Ihe Foundallon is in a strong position lo cA)ntinue to raise funds and supwrt the delivery of high-
quality medical research and eduGalion al Sl Mark's Hospital.
The CEO ¥￿Iked closely with the Clinical Director. lh& D&an and the Research Ove*sighl Committee lo
agree the strategic research priorilies.
Pagc 7

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 31ST MARCH 2023 (contlnued)
Major rosoarch projects funded from new and exlstlng funds
SURGICAL & ENDOSCOPIC INNOVAnoNS
Surylcal Rol)olics RoB￿r¢h Programm• fw colorectal and anoreclal surgery
Whilst robotics had been established for other surgical speciath'es. nam8ly urobgy and gynaecology. il
had not been widely researched and implemented for colorectal and ar)ore¢tsl surgery. This need was
one that St M8rk's was delemiined lo address through ils funding of a Davind rot#)l and the
estsbllshment of the roboti¢ programme wl¥ch started in 2018.
Betsveen 2018 and 2022, almost 4CrfJ robotlc owathy)s were performed. In the first quarter of 2023.
46 proceduros were ccmnpleted.
A unique aspect of thè robollcs programme is the types of procedures being pgrform¢d. which are
different lo other inslilutions. Specifically. over the lasl four years, the team has been developin9 their
expertlse wrth..
Synchronous lIv•r￿OI ros•rtlon$'. Ihese hav8 been performwj in ¢>)Ilat￿lratIrrtj with surgical
col￿a9UeS from Hammgrsmilh Hospital. London.
Pelvlc exent•iatlons: this is major Gompiex ean(*r surgery which involves the removal of pelwc
organs.
Robotlc II•ollanal pou¢h surg•ry.' Ihis work has boen dovewd Into P￿)lica￿Dns and is an
example of how we are disseminaling new knowledge.
The robollcs plaffomi continued lo be u5etJ by urolcgy. gynaecology. and maxillo•facial surgical
colleagues In ihe Tnjst. albeit Iho focus ol the Pmgramme, unliko In other UK hospitals. continued to be
colorectsl 8urgory.
To help meet the Programme's educational ¢)bjecbve to beo)me a national and inlefflalional trainin9 hub
in robotic colorectal surgery. surgeons from UK and overseas hospitals conllnue lo be hosted for on
day case observatsons. To data, more than 60 surgeons have spent a day al Sl Mark'5 observing and
learniw from our robotically trained cobrectal surgeons, of which Ihere arg 9. There is also a tralning
programme In plac8 for other St Mark's ￿rgeonS wantiryJ lo devew their robotic surgKal skills.
W6 thank the donors who have helped us fulfil our role lo seed fund the programme. Finan¢ial
responsibility has now transferred to the Lond￿ North West University Health Car• NHS Trust. and the
Trust is looking to acquire al least addthonal robots.
Rot<Jtlcs is now finnly eslabllshed In the surgirAII praGli¢e at St Mark's.
The VVAVE $tudy
Colonoscopy Is one of the maln endos¢opic investigations to deiecl and pravenl bowel cancer.
Colonoscopy s6N¢o$ in the UK are @￿TiOn¢1ng growlng pressures. whith rneans that the national
waiting lime targets are not bwng mel and procedures and bowel cancer diagnoses are beiro delayed.
In response, endoscopy units have b88n exlending opening hours and offering weekend procedur95. but
this is not sustainable. In a resourc8-constrained envir¢)nrnenl. the andoscopy profession must find new
ways to impTove effIC￿ncY and quality. The WAVE Study is one of Sl Mark's Tesponses to this need.
For the first lime. a controlled trial has compared colonoscopy techniques (water and water & carbon
dloxide Ihybridl) lo identify which should be used to open the bowel wall to see the lining of the bowel.
Understanding wttich lechnique is better at reducing pain, the procedure time and need to reposition
Page 8

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES, REPORT FOR THE YEAR ENDED 31ST MARCH 20231continuedl
patients, as well as beiro the mosl effective al improwng the detection of pre-cancerous and cancerous
growths, would help the colonoscopy procedure to bo pwfornied more effieienlly wth potentially better
tol8rance and OLrt￿meS for patlents.
The WAVE study comple18d in the year urvjer reviww. The hypolhesis th81 the hybrid technique would be
more efficient lo perform was proven correct.. the study showed it offered a 4-minule faster colonoscopy
procedure. with no adverse effect on patient Lxmfort need for sedation and detection of polyps. Th8re
was no difference in patient pain scores, in the ONprall number of loops form8d by the colonoscope, and
In the polyp and ad8noma delection rates betsveen the groups. Pats"ents wthrgoing hybrKI colorM)SCOPy
were requiffjd to ¢hange pO￿tion less often.
Tho findings are 8xpected lo reach an extensive audience of cok)noscopists Ihrough publlcatb)ns. and to
have signrficanl impact in terms ol the training arKI praclicfj of colonoscopy.
EARLY DIAGNOSIS
PERFECTS
CT colonogr#phy ICTC) 1$ an altem8tfve lo tradltional colonoscopy and can be u$ed for frail. older arHI
léarful patients lo identrfy pre-cancerous and cancerous growths. However, it is widely recognlsed that
the accuracy levels for idenlfying these growths vary $ignifi¢antly across the UK. from 140k in some
C8nlr8s to almost 100% 81 St Mark's.
The PERFECTS researth pmgramme, which was a uJll8boratlon bolween Sl Mark's and the radlology
faculty at University Colleg6 Lon￿ft Hospttals. Iralned 70 rad￿)logIStS pracliung CTC in th8 UK lo a high
standard of proficiency. There was a 20% uplift in pertomance, and Ihis was sustalned for al Igasl one
year.
The results fr￿denCed the IralnlTrJ model {onlkne modular IraiThng vrith iThlividualisad feodba¢k), arKI the
Inlerest generated has led lo the dev8lopmonl of the nation81 CTC training and accreditation programme.
This will involve the Gore PERFECTS team and will be aimed al radiobgisls throughout London and the
UK and radiographers due lo the chronic shortage of radiobgists.
CTC in g￿d hands is a Strong diagnostic tèst and upskllling rndiographets Is a key element of the
research because there are not enough radiobJisls tralned in CTC and their level of eX￿rtISe is a150
variable.
A key question being explored by nattonal programme {PERFECTS 21 is whether radiographers are
Justifiable altemalive io radiologists.
We are graloful lo the donors that contrlbuled tovrdrds PERFECTS and now to tho nattonal programme.
Tho Lynch Syndrorne Canc•r Pr•v•ntlon Study {'LynC' Study)
The St Mark's Lynch Syndrome Clinic e4)nb"nues lo progress a r8n9e of projects which il believes ￿Uld
be rapidly scaled-up into medical pfadice for the benefit of peopb8 With Lynch Syndrome.
Alms of tha Lync Study..
11 Effective dk4gnosis and idontificalion of poople wth Lynth Syndrome in th¢ UK.
21 Improve Ur￿erstandIng of the biok)gical mechanism of carter development of Peop￿ wilh Lynch
Syndrome.
31 Development of more tests which facAlitate the prevention and early diagnosis of cancer in peop￿ with
Lynch Syndrome.
41 Reduction in variation and improvernent in accoss to ￿re for people with Lynch Syndrome in the UK.
Page 9

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 31ST MARCH 2023 (continued)
Across three Pfoiects, we can develop a new paradigm in Lynch Sy￿1rrXne cancer prevention, built over
a decade of three inlerconneclgd projects. These involve collal)oratic￿s other UK academic centres.
bul leé by the Lymch Syndrome Clinic al Sl Mark's.
Early diagno8ls of dy•plasi&lcanc•r in IBD pall•nts uslng a nov•1 non-Inva•lw ts•t
This collaborative project be￿een Sl Mark's and the InslitLrte of Cancer Research aims lo develop
blood lesl to spot earfy svJns of cancer in Infiammatory Disease {IBDI. Using the test wukl holp
target endoscopy lo PaI￿nIS most in need.
The r8seaTch team has seen a svJr￿tUre in Ihe blood that, lo a ￿rge extent. mirrors what is seen in
endoscoplc tissue samples Ibiops*sl. Thay hope the r8sear¢h Can lead to the development of a non-
invasive lesl for eady cancer detection that will b8nefil people with IBD around the world. St Mark's Is In
a strong posllion to athieva this because il has of tha world's largest cohorts of IBD patients. and
strong national and inlemalional links with 18D col￿a9￿eS. This provid8$ acc8SS to thousands more IBD
patients UNJer endoscopic survoillan¢e.
IMPROVING DISEASE UNDERSTANDING, STRATIFYING RISK & PERSONALISED MEDICINE
PrgcSslon Modlcln• and18D: Can g•n•tlc clue• fr(xn ¥n Infiammatory btyw•l dlMaM patlant's gut
pr•dlct whethgr th•y w511 r•8pond to troatm•nt?
This project is a step towards a futurg where preusion medicine Can ba reallsed for Crohn's disease and
ulceratsve colitis, the condrtK)ns collectively known as Infiammalory Bowel Oisease IIBDI- Understandlng
whi¢h chemicals drive inllammalion in IBD may reveal predictors abovl the drugs pakn'enls will. 8nd wlll
not. respond lo. This means the nghl treatmonl ¢an be started eartier and patI￿ts stay well for longer.
To cons01idale this topic of interasl and lo undersland the wider context ol this research. the Fèllow
leading Ihis project co-authored a rewew arti¢ie In a beading joumal, Ggstr0enÉer￿y. about predictive
medicine in IBO with leading inlemalional expgrts in Ihls I￿k1.
The Fellow's bme 81 Sl Mark's has been extended by 8 year. and he will now ￿ave in August 2024. Thls
will give him more time to apply the pasl few yeats ol leaming in laboratory and biolnfomalics skills to
the prospeGlive data h8 has been collecting.
The F8llow's success will be measured by compl8lion of a succassful PhD and pres8nlalion of original
findings al local, n8tional. and int8mat￿nal resoarch conferenc8s. He also aims to publish his wot1( in
internallonally recognised peer-revlewed joumals lo b8 abl8 to coniribule to this important field, which
has the potential lo Iransft)rm pabonl caro.
Advanclng understandlng of the cancer pathway to Impro￿ the future detèction and pr•v•ntlon
of cancer In Inflarnmatory bowel disoaso patients through pwsonallsod surveillance.
Currently, there is a lack of understanding a￿ul how cancer develops in certain groups of pabents
known lo be more likely lo d8velop the disease, which mgan5 their future risk is more diffiwlt to pr￿￿1¢t.
Consequently, end05￿pIC monitoring by Cdon0￿pY {one of the main diagnostic Invest￿allonS to
detect and prevent LN)wel cancer) is not able lo be matched lo individual cancer risk, and clinical
strategies to prevent cancer through early detect￿n are somewhat ineffecb've. This collaborative project
be￿90Th Sl Mark's and the Instslule of Cancer Research sought lo improve the molecular underslanding
of cancer developrnent in Ulcerative Colitis and Crohn'&lColitis patients.
11 similar mutations are found between biopsies. Ihey can be labelled as beirvj part of the same 'chJne.'
and by measuring how many biopsies are part of the same done. th8 size and locations of the clones
can be measured across the C￿On.
Page 10

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES, REPORT FOR THE YEAR ENDED 31ST MARCH 2023 (continued)
The work has revealed a finding with dinlcal implicallons. The current praclice for K*edi¢ling a patient's
cancer rlsk and conducting suryeilLqnce is to look for dones under the microscope. However. by applying
mol8cular lechniques to trace mutatKJns, Glones have been eypowj in parts of the colon that bok
harmless by eye and hislologically.
This research will. therefore. have an impact on what method is used to condJJct suNeillan¢g11.e.. use of
geneliclmolecular tests lo support current pradice) and how Ihese genelic tests are used (i.e.. where
exactly biopsies are taken. how many and how oftan).
DRIVEN: Dfrvelopment and validation of a prfroperativo risk •trotifi¢*tion m•thod for patl•nts wlth
rlght-slded bowel caDC9r to improvg aurvlval outcom
Knowing preaoperativély whether a patient is likely lo have a good or pLM)r prognosis will make il possi￿9 10
tailor surgical and medical treatment lo the indivKJual. If apwopria18. pali8nts al hvJh risk of poorer
outcomes can be offered rnore gxtensive surgery andlor chemotherapy prior to surgery.
This project Involved re-evaluating pre-operative computed tomography (CT) CT scans aPpI￿n@ a novel
$l•ging method called CT TDV. Pre-Op8rat1￿ biopsies were 81so reassessed.
Scan and blopsy resums were compafed wlth both the cyerative t8chn￿Jue used and patients, surwival
out￿me9 lo Infomi the development and validation of a risk slratificalion method.
Th8 preliminary results are 8ncouraglrKJ regardlr4J a no￿1 method to stage right ¢>)lon ￿nCer and
Idenlblylng those Ihal may bemfit Irom more extensiv8 surgery. The results are planned to be publishod.
DRIVEN was a coll81)or•live proio¢t be￿n St Math's and rndiology aThJ pathology t>)Ileagu88 at The
Royal Marsden Hospltal and ts I￿trIute of Cancer Researth.
Pr•dicling canc•r r•cuff•nc• in Infiammatory 8¢M•l DIMu• p•tl•nt•
Ulceralivg coliti$ and Crohn's disease both have an associaled bowel cancer risk. The cancer risk
inGrea$es wllh the severity and duration of the disease, such that about one in three people with lorKJ-
8landing disease will develop ￿ncer. To mitigate this risk. these paI￿nIS we offèred regular
lonoscopies lo look for eady sons of cancer, enabling appropnale action lo be taken in good timo.
However. colonoscopic surveillance would b8 improv&J rf we had a more ￿nSitIVe way lo predict which
people are al hvJhesl risk of developing can¢ar.
This project is looking 81 dyspLgsia in ulceralNe colitss. one ol the iwo most common forms of
Inflammatory Bowel Disease, and will use genOrn￿ biomarkers to predict cancer rgcurrenc8 in patients
who have undergone end08￿piC resection of these lesh)ns.
Why do Sorng patlonts wlth Lynch Syndrorne develop cancer and oth•rs don't? Improvlng
undèrstandlng of ynetlcs and Immunol¢)gy to support cancor prevention
Funding for a research fellow lo lead this project was seujred in 2022-23. They have now commenc£d
the work. whith is a C•)Ilaboration wlth the Institute of Cancer Research.
This project will look at the key difference5 in healthy. pre•cance￿$ cancerous tissue in Pat￿15
with Lynch Syndrome, a type of familial can￿[ s￿d[orne which increases a pe￿On'5 risk of various
cancers, including bowel cancer.
The tissue that will be tested has been donated by patients dwn9 their routine colonoso)pies and stored
in the biobank at Sl Mark's.
Pag¢ll

ST MARK'S HOSPITAL FOUNDATION
TRUSTEE8' REPORT FOR THE YEAR ENDED 31ST MARCH 2023 {continu•dl
By understandiThJ more about the genetics and IMMU￿ landscape of tissue and matching this to
clinical dotails about individual patients. we hope lo understand more ab(yJl why some patients with
family history of cancer develop the disease whibt othws do not The goal is lo prevent more cancer In
young people.
Cllnlcal Out¢om¢s in Perlanal Flstula Database Study
The Study's aims and objectives are to store dinical, demographic and outcome data from patients with
perianal fistula5 vllh infom)ed consent to identify factors correlated with treatment response. 11 will
provide a better understsnding of the fa¢lofs that contribute toward5 wrianal fistula healing. Wg know
that not all fbstulas respond to treatment. so we would like to investsgale ihe sel of cirGumstanGes in
whlch 8 fistula is rn0￿ likety to close.
More than 21)0 palienl8 have been re¢ruited and patients ￿ntinU8 lo provida consent to be part of
study on a weekly basis at the Central Middlesex HospItsI 5itg.
OTHER RESEARCH INITIATIVES
Establl8hing tho I￿raStructur• for a now futurtrproof r•••arth r••ourc• at Sl Mark's
The Sl Mark's 115$ue bank Is making il possible to ￿llect fistula tissue and othèr samples from patlenls
with informed consent lor use in lulure research projects. Whilst a proportion of these samples will bo
from pall8nts with very rare eondltions, others arg rare bul ¥9on in ￿49h W￿ume al Sl Mark'$ Hospital.
The rate ol samplo ¢ollection has increased rthv that Ihere are freezers at b)th the St Mark's and
C8nlral Middlesex Hospilal srtes. As of April 2023, 275 patients have been consented and $50 samples
have been collected. As well as Ilssue samP￿s, blood and blood serum samP￿S ar8 also belng collected
and. in tho future, Stool samples will also be ￿lleCted.
The ts55￿ bank represents a futurtrproof research resource. Ovor lim8. il wlll provide a rich Sour￿ of
data, whlch one will not bo able to find In any ott￿r inslrtulw)n In the UK in the same volume.
Rosearch projects supported by designated funds
Ub'lising the 'pouch MDr to improve outcomes for Fouch paI￿nts.
Advances in the management of perianal Crohn's diseasg.
R8s68rch into the palhogenesis and management of pithidal disease.
Understanding and optimising the perioperative pathway of the complex cancer pati￿1.
Understanding how best to counsel patients for restorative procloc4)leclorny.
Age and ethnic dispar11￿S of risk and outcomes of Infiammatory Bowpl Disease as¥Q¢kqt8d
dysplasia and ￿10reCta1 cancer in ￿l￿ratIve (x)litis.
Understandlng the n￿P1aStiC risk of serrat&J ￿lonS in Infiammalory BcA¥el Diseas8.
Page 12

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 31- MARCH 2023 (continued)
Coming up in 2023-24
ENDOSCOPY+
St Mark's dellvers a cross-site endoscopy service from ￿￿1th¥￿ck Park aTrJ Central Middlesex Hospitals.
One6 the refurbishments of the endoscopy units al bolh siles are complete. overall endoscopy capacity
will increase from eight procedure rooms lo elevon. four at Ncrfthwi¢k Park and ¥even al Central
Middlesex, the new hub of Sl Mark'8.
The aspiration for endoscopy at St Mark'3 is-
To dell¥er out8tandlng tr•atm8nt to local and t•rtlary patl•nts. undertake rosoarch that will
Impact futuro endoscopy practlco, and dellver fIrst￿lasS teaching and •ducatlon In tho hospltal'•
rol• as a Natlonal Tralnlng Contro for •ndosGopy.
Endoscopy+ is how St Mark's will tran$fomi r•S￿rth. leaching. and training in ondos¢opy. The State￿f-
Ihe4rt, cross-sile faeility will ben8fit and transcend local communities and improve the hospital's
rgse8rch and education capabiliti'es. It will have a far￿eaChing impacl.
Whilst the NHS has ts)mmilled a multi-mlllion-pound sum for the relurbishmenls of the endoscopy units,
and provlded a capital budgel for some equipment. there is enough funding available to meet every
need.
A re3trb¢ted lega¢y will g81 fundralsir#J undevway. and wlth the support of other donors t￿. tho ambltions
for Endoscopy+ wll be realised..
1. To develop anej contlnue hlgh quality re8earch wlh the potential to impact futuro end08LYJPy
pracllce and quality of care to patients.
2. To transform the quality of the leaching and training Sl Mark's can ddiver.
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ST MARK'S HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 31ST MARCH 20231wntlnuod>
Educatlon
St Mark's Academic Institute. whlch is funded by the Foundalk)n and SUPFQrted by course fees and
swnsorship revenue. is dedicated to education and dissemination of best practice in tha field of bowel
disease al Sl Ma￿'S Hospital.
Drawing on the medical. surgitsl. and nursing expe￿'se t#)th at the Hospital and further afigld, the
Academic Institute runs specialist courses attractbng more than 2,000 practitioners from the UK and
overseas. The Foundation operationally suppK)rts over 30 research felbws undèrtaking either MDS OT
PhD5. Thg Ac8dernic Institute sUPPOrts and promotes a vibrant research ethos.
F￿on¢k Salmon founded St Mark's Hospital bn 1835 as the Benevolenl Oispgnsary for the Relief of the
Poor Afflicted with Fistula. Piles aTrJ oth8r Diseases of the Rectum and Lower Intestines. Although the
Hospital now has a far broader remiL it Is fitting that Salmon's goal, benefitting the patient. remains the
objecllve of the educat￿n81 ¢ourses we offer today.
A¢ademlc In8tituto dopartment staff wlthln tho Foundatlon
Multi-media webcast producerlaudiowvtsual Cftrordlnator
Course and education mana9er
Course and digital admSnlslralor
R98earth Cowordinator
Acadomlc Instltut• Cours• Ovorvl•w
A8 the flrsl hospi181 in ts world to specialis8 in color•ctal disease, St ma￿.5 Hosprtal h85 embraeéd the
educ81ion of others. SinG¢ th8 1950's doctors have Come lo Sl Mark's Hospitsl from all over the world lo
leain, with many reluming lo establish the ¥pgualism in their own country. The Ireatmant of intestinal and
colorectal disease has now becomg a specialty throughout the workl and al St Mark's.
The Sl Mark's Academic Instftute has a￿￿$$ lo a wealth of highly qu8ltfied and experlenced staff who
have a proaGliv¢ attrtude lo education. Courses vary in length and attract a broad range of poslgraduat•
medical stsff.
All educabonal courses are advertlsed on the intemet and wa th8 medical 8nd p8ramedlcal press.
Allendees. for the Sl Mark's Hospitsl's Fronliefs meeting and postgraduate teachlng ￿urse8, arg frorn
thro￿hOUl the UK as well as all around the wortd.
Academic Institut• 2022-23
In contrast to 2021-22, when we experienced the aftennalh of COVIt>19. 2022-23 was very refreshing in
terms of overseas visilofs. We were able lo welcorne 8 great number of ws110ts. Wa had 39 overseas
clinical v¢silors in this peric*J. Some of them were general observers. some were clinical attachments and
other were clinical assislanls. They came from Spain. Ilaty. Israel. Australia. Chikg. India, Greece. Turkey,
Brazil, Belgium, Poland, Taiwan. Portugal. Saudi Arabba, Norway. Mexico. Switzerland. Netherfands.
Hungary and Singapore and spent drfterent kThJth5 of lime wilh us.
Pag¢ 14

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES, REPORT FOR THE YEAR ENDED 31ST MARCH 2023 (continued)
STMARKS
O¥¥EL MOSPIT
Alberft) Gm'cirt Pir¢ro, Sofo¥is Pmi*leipMoiiins & .lthi'co DoiiiiiFICI
STMARK5
AC 4 O e M • ¢
l N S T l T U T E
Tho thallgnges of the COVltk19 pandemic meant new ways to delNer our edwalion. The preferred mode
lo deliver our courses seemed to change from online only {due to the COVID restrictions) to a hybrid mode
where allendees can join us Trper50n or online. This year. we delivered the last of the series of courses
of our ENDOcation series. The series was very successful and most of the c¢xJrses in the seri85 wer8 fully
booked 15LXI registrations) and we had a h*3h numw of attendees. These o)urses have aL80 been
Page 15

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 313T MARCH 2023 Icontlnuèd)
uploaded to our website and are openly available. In this way we spread our teachings nationally and
internationalty.
We had 8 new course In Oclobw called Pefvic Floor and Compbx Proctology. This ¢OUf8e was aimed at
surgeons. trainees. and tsJnsull8nts. It was a IAYo-day course which provided updates on the various
aspects of p8lvic floor surgery and compl8x proctobgy aimed al colorectal surgeons.11 was a hybrid event,
where attendees jolned us in person al Sl Mark's Hospital as well as online. The firsl day wa5 primarily
pelviG floor and the second was be airned at complax proctdogy. It was hlghly $u¢cessful and welcomed
by all the attendees with very gocd feedback.
Our flagshlp ¢ourse in November 2022. 'Frontiers in Colorectal and Intestinal Di804$9'. 'Spotlight on
Inflammatory Bowel Disease,. was an &nom)ou$ $u¢¢ess. The event was a synchronous hybrid event h&ld
in-person al the Glaziers Hall. in London and online using hKJh quality d￿lIa1 streaming from our custom
designed broadcast studio and was very well supported through sponsorship income. 11 was very
professional, highly engaging, inleractivg and thought provoking. We had 150 in-pers(In attendegs ea¢h
day and 2,880 wewers, from 60 d￿erent C*)unlries, induding those who viewed th8 conference online after
the ¢vanl. We received extremely positive feedbad( from attentjees on the overall delivery and content of
this course in person and online.
"l Ih) l¢xl Ihal
Ns by for Ihe bos1 cob)r•ct
9￿*1h•oPpCthth (lol I•B•
The 'Hofizons in Inle$tinal Rehabilitation & Home Parent¥al Nulritlon. course look place in Dacernber. It
was delivered as a hybrid event. with attendees ioining us in-person at the Royal College of Physicians in
London and online. Even though. we faced a few challenges with snowy weather and train strikes, the
Page 16

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES. REPORT FOR THE YEAR ENDED 31- MARCH 2023 (contlnuod)
attendance of this course was excellent., 220 peotAe joingj u5 onhne aTrJ 65 Peop￿ attended in person.
We had atten(lees joinir#J in from all over the wothl.
This year, we had two patient infomialion evenings run by the Familial & Inherited Cancer team.. The
Polyposis Registry inforniation evening and the Lynch syndrome patient information event. These sessions
gave infomialion about Lynth s￿droMe and Polyposis syndrome to patients and their relatives. Both
events were well attended arKI welcomed by paI￿nts. and we will support them again next year.
Changing the delivery mode of educalion. di(1 r￿1 onty open the opportunlty lo ￿ath particbpants in corners
of the worfd we dld not reach before. but it also brought us the opportunity lo deliver a high standard ol
education wllh Un￿striCted numbers of attendees in a more sustainab18 fomial. There arg plans lo ￿ vamp
and revise courses that were offered pre-covid lime. however. we need to address some challenges lo the
physical course venue al Ihe hospttal before ￿ ¢an prowde more ¢ourses.
Cour$6s are charged al a starnlard and rJ)mparabl8 rate for gducational CoU￿S n Ihls r￿d and
dls¢ounlgd place are often Fyovided lor trai￿. Howevèr. th6s year has brought about an evolution to
more spon501 led education proposition. We have been abb to offer many of our ¢ourses as frets lo attend
thanks to the generosi
ofours
nsors.
Course nam• and doscrl
on
Abdomlnal Carg- 20 cr•dlt degrno- Unlvernlty module
ree-lev81 module for healthcare
rofessional$
ENDOcatlon •ndo8Gopy W•blnarn
Series ol webinars lor education In endos
Frontlorg In InlMtlnal and ¢oloreGlal dlsoa
A flagship three4ay annual inlem81ional conference covering a broad fdriety of lopbcs. Ilvo
sur
erylendoscopy aThJ slate of the art ke
note tslks
Ga8trolnt•stlnal Anatixny and Phyiiology 20 Cr•dlt O•9￿- L•v•l Modul•
A course for he8llhc8re professionals with an interest in caring for ￿oPle with gastrointestinal condlllons and
diseases..
ainln
a universil
award at 20 credits
Gastrolnt••tinal H•althcar• Asslstant Study Day
A virtual one-d8y_ slud da
for heallhcare assistants wilh an interest in
Ga$trolnt•stinal pathology study day
Identifying and re
ortin
on
aslToinleslinal tho
Gastrolnt•stinal study day for nurs•s
siurn lor nurses lo Increase their underslaThJin
of a variel ol
Horlzong In Inlestln•l Rehabllltatlon & Homa P8r•nt•ral Nulrltlon
3-day online course with Lectures and bre8kout seminafs looking 81 chronic and acute Intesllnal failure and
home
arenleral nutrition
Independent Study 20 Cr￿11 d•grthlevol unfvornlty modulo
For healthcare
rofessionals lo undertake a bes
ke module on a
Low Antèrlor Rose¢tlon Syndrorne Mastorclass
For hÈallh¢are
ofessionals,
articularl nurses who care for
Lynch Syndromo pallgnt Infommtlon ev•nlng
Inlomalion evenin for
lienls with a dia
nosis of L ch s
Polvlc Floor & Proctology Cou
A Iwo-day course which promded updates on the v8ri0US 8spects of pelvic floor surgery and complex
proctology for the col￿act81 surgeon. The first day vras primarily pelvic flwr and the second was aimed al
lex
roclol
Pelvic Exonteration Masterclass
A maslerclass for heaKh¢are
rofessionals such who care for
Polyposi¥ Registry patlent infommlion evening
lnfofmakn.on evening for patients with a diagnosis of a rM)Iyp05is syndrome and they famil
matters
astrointe51inal care
astrointe8tinal t Ics
stvointestinal to
ic of their choice
after rectal cancer sur
ndrom8 and their families
le unde
oin
IMC 8xenleration
Page 17

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES, REPORT FOR THE YEAR ENDED 319T MARCH 2023 (contlnued)
2111 Century Nurslng Managmnt Mastwdass
A virtual masterdass for nurse mana98rs aTrJ aspiring nU￿e manaws
Incomlng projècts and challfrnges
With the change in trend in course delivery mc*Je. wo had a few techni¢al challenges du8 lo the ouldaled
infrastructure currently available at thè Avery Jon8s Education Centre, at the Central Middlesex site.11 has
become apparent that there Is a need for a signrfant rofurbishmenl of the Lecture Theatre. New
infrastructure is needed to delivef in-house courses from our hOS￿al lo keep UP with the naw trend of
hybrid courses and deliver excellent quality courses. Medium lo L4rge ts)urses had to be delivered
elsewhere lo maintain a high stsndard of Quality.
Our NHS Trust h88 also acknowledged Ih8S8 issues and have agreed to improve tho AV infrastructurè for
the education ￿ntre. The FoundatSon 1$ r8vle*ing opportunili8S to support part funding the improvements.
Other NoLibl• Educatlonal Aetlvltl•s
RMtrUc￿re ol our EdUc￿lOn Team and cour•
At the beginnlng of 2022. we wer8 delighted lo welcome Mr Akash Méhta as our new Director of
Education. Wilh his help, the Academic Inslilule wll be in an èven better p)sition to meet its aim lo bo 0
Slrong leader in coloreGtsI education. We have also started lo chang8 the way we daal with applicallons
for visiting fell¢)ws. The aim is lo slructure th6 process by inlroducing a new applic81ion fom for each
year staling th¢ different m￿all1￿ ol obsthwership and dales awailabi8 for them. We are now in the
process of revamping som• ¢ourses that wer8 onco very popular but are now not as relevant. For
example, our F#)slgraduale lea¢hing lemi COUTSe.
We have received a few educational offers from China that we aTr procassing and analysing. These
offers open a wide spectrurn of benefits for the St Mark's edu¢atlon brand and is being carefully explored
for inclusion in our wider aGademic strategy.
RM•arch C4>0rdlnallon
The department's full-lime research co-ordinator supports thg Research Fellows in a number of key
ways, including their medlcal granl applications and research impact measuromenl reporting. The
research process can be adminislralively o)mplex. and we have SUc￿$fUllY developed relaliorsships
and collaborations wlth other researth institut￿n$, fonn81ised the proG8s5 for eollecllng research metrics
and developed a programme of talks for the Research Forum.
Nurne Educatlon
The gaslroinlestlnal care palhway and the indivKIu81 ￿¥XIUleS continue to nm each year al l)oth degre-
level and maslers-level. accredibj by BlrmlrvJham City University.
During this year 74 nurses and allied health professionals attended university ac(xediled modules, 2
completed a degree-level award ar￿ 102 intemal staff attended frée educational sessN)ns. Nurses,
healthcare assislantS, Student nurses and pharmacists aTbd 99 intem81 and external stsff attended one of
three study daylma51grGlass. We also welcomed 11 Spantsh nurses for a bespoke edu¢at"on day.
Pag¢ 18

ST MARK'S HOSPITAL FOUNDATION
TRUSTEES, REPORT FOR THE YEAR ENDED 31ST MARCH 2023 (continu•dl
Financlal Review
Income
The Foundation received donations from a *rdri8ty of source5 and is not dependent on the support of any
particular individual, corporation or class of donor. Totsl income lor the year was £2,648.83112021-22'.
£1.722,8531, an increase of $4%. The main driver wa5 an inuease in legacy and education income.
Donations linG1￿￿lng lega¢y gifts) were £1,981,629120￿2l.. £1,283,887). an increas8 of 54%.
The increase inlogacies and education income has changed the ir*x*me mix in the currgnt 2022123 year.
Income from legacies represented 29% of total 1￿Me, as shown in the 2022123 chart below. This
compares wth 14% in the previous year. In absolute tems, legacies generated £772.753 in 2022123, an
increase of 211% over £248,277 in 2021122. Income frcffi edU￿t￿n Gourses represented 21% of Ihe
total Ineome as compared with 22% in the prior year. However. In absolute value terms, income from
education courses increased by 45% frorn £375.469 to £544,020. Legacy income can vary significantly
betsveen years due to its inherent nature.
2022.2023
2021-2022
0.1%
4%
4X
45%
14%
29%
59%
22%
21%
Expandhure
Total expenditure lor the year wa$ £2.273.32412021-22'. £1,841.1881. The increase in ts odu¢alion
costs changed the expenditure mlx in the current year. Education exF*￿IllUre as a percentage of lolal
•xpendllure increased ty 5%. Research expenditur8 made up a lower share of the total expenditure,
down from 73% of total exp6ndilufe in 2021-22 10 66% in 2022-23. In absolute lems. r8sèarGh
expenditure incroased by 12%. compared to the previous year. Th8 cost ol raising funds as
p¢rcenlage of totsl expenditure remained the same, al 10%, bul irKroased in absolute lemis.
ZOU.Z02a
io%
2316
É6%
The Trustees continued to rewew th8 cash held on deposit. holdirwJ sufficient short-tenn cash to meet
current obligations. Net incoming rEsource5 for the year amounted to £375.507.
Total funds at the end ofthe year were £4,279,535, ccffnpar&J with £3.904.028 in the prewous perK)d.
Page 19

ST MARK'S HOSPITAL FOUNDATKIN
TRUSTEES, REPORT FOR THE YEAR ENDED 31ST MARCH 2023 Icontlnued)
Funds and Reserves
The Trustees are satisfied that ad&4uate fvnds ar& availablg. as shown in the notes to the accounts, for
the Foundatlon lo meet its obligations. R8slricled Funds are for Part￿Ular 8reas of research as specified
by the donors. Designalgd Funds are funds set aside for future research or educabonal FWjèCts as
approved by the Trustees. Unrestricted Funds are reserves to primarily support the Foundation from any
unforeseen fluGtuations in income. From tim8 to time and sutr4.ecl lo the Quantum of unreslricled
reserves, the Tnjstees may designate a wtion of funds from these reserves for important research and
educallon projects not already wvered by ongoiThJ projects Irom rnstricted funds.
The Trustees revlewed the reserves policy in tha year and agreed a policy of o lar9el for unrestricted
reserves equivalent lo a minimum of six months operatsng eXpend￿re. Unrestn'cted Reserves at the
year.end w&re £862,196. equivalent lo just under ￿e1ve monlh5' total unreslricled expendrture.
Although the acluals are higher than the six months minimum. the Trustees agreed It is prudent to hold
highor18v81 of reserves providing reasonable contingency cover. The Foundation has lorecast incom&
and expendiluffj for 12 months from the dale of Ihis report. Based on the forecast. Unr￿tricted Reserves
at thè and of the next tsyolvo months are ests'maled lo be within the trustees reserves policy.
Restricted Reserves {represenling funds raised specific projects currenuy in progress) wero
£2,858,645 al the year-end, compared vAth £2,743,281 al y8ar4nd in ihe prior ye8T.
Investments
The obleclive of the Foundallon's treasury policy is to yoduce the best financial rolum vAthln an
acceptable levol of rlsk.
The Truslaes have continued the policy of hokJirvJ the financial assets of th8 charlty In fixed-tem sterling
deposit accounts.
Thg funds are deposited 8cro$$ several financial institutions and the cash position an¢J fixed deposlt
turns are monitored on a regular basis. The Finance Manager reports al regular Tmstee Meetings on
th8 perfcfinance of the deposits.
Page 20

ST IIARlfS HOSPITAL FOUNDAnoN
TRUSTEES. REPORT FOR THE YEAR ENOED 31- IAARCH X123 {continuedl
Statement of Trustees, R•sponslbilltles
The Twst••s Iwho arn also trts directors of the St ma￿.$ Hospital Found8tion kn the PUTposes of
comp8fty Lawl responsibk for preparirwJ the Rèwrt of tha TN8tees and the financkgl slatemgnls
In accord8nce with applrable law and United Kngsom Accounting Standards Iunited Kingdc
Generalty Accepted Accourrting Pr8CtKe}. indrjjing Finanwl RepNb'rg Stsndard 102 Yhe
Financi&l Re￿rtIng Standard appl￿￿￿ In th8 UK and RewtAr crf Iroknf.
Company law requiTe8 the TrLK8lee8 to prepare f(nanaal statwts for eath financigr year wh
9rve a tru* and fair vivA Of1￿ srate of affairs of the chorr1a￿e (Y￿panY of the uKoming
re80ur¢es and appI￿*￿n of rex)Ur￿. incbjdirg the and expen¢Jrturg. ollhe tharitsb
company for that per*)d. In pre￿ring tho¥B fnancml slaternnts. the Tru$t6e8 are requ￿ed to
• select suitsbb ac4)￿nt￿9 pth'es and then *pty them consist￿ty
• observè the methc#JB ￿ prinupl88 in the C￿nty SORP
• make Njdganents eslknates Ihat arp reasonable aThJ prudent
• prepare the fin￿￿81 st8teffw18 on the going (x>￿*M basi8 unbB8 it is I￿PPrOpn&ta lo
pr•wme that th• charltable wll bu8bwss
The Trusle&s are re8F0nS**￿ fc* kerying propw ￿Counti1￿ records which di￿￿)80 wilh
re88crable accuracy al ary Ilrm the fn8n¢ig1 p08thn of the tha11t￿le company and lo ￿able
them to ensure that the financial statements o)mpty with the compan￿ kl 2CQ6. TIK*y are 8180
responsibk8 for Salty￿rdi￿ the assets of ts thantable cunpany and h8n(x tskn'ng msongble
8teps for th• preventicffl and detectKJn of fraud aTrJ ot￿r irwul81ittes.
In 80 for a8 the Trustees are awar•".
• there18 no relev￿1 audit infcfflwtirm of whJ¢h the thaiilth cMip4nY8 •ulMors a
unaworn., arKI
• the Trust8e8 have t&k6n all 8*p8 that tw ought to have tak￿ kn make thernsel¥o8 awarn
of any ￿levant tr**)ThnatK￿ ar￿ to eBIAbliJh thatthe a￿11￿ we aware of Ihat
IrrfDrnal#)n.
Membern ofthe F￿ndati¢￿ guarantee L¥xtrilyJl8 arn￿￿ not exc*etlvig £110 the assets of
the F¢)undatk)n in the event of wir*Jing up. Tho totsl numberof suth gLwrnnleB8 81 31" March 2023
B evJhl. TnJ8tees are Membews of the FtyJThJatJon. trArt this entitb8s them onty to vol￿9 dghts.
The TNstee$ h8¥e no benefickgl intere8t in ￿ Foundatbn.
AUDITORS
The auditors, Knox Cropper LLP, wlll for rHFpClr￿ •1 th• f￿cOMing General
Meth'r4.
This reFQrt has been PfBpared In &c£*rdance with the wlal PmiB#ins crf Part 15 oftr
Comp8ni¢$ A¢1 2006 re￿irt9 to small
Apwov•J by order ofthe bcord of Trwl•e8 on
d svJned beh#llby'.
SirTkn*8 Trouwe
Chaim*n
Pa8¢ 21

ST MARK'S HOSPITAL FOUNDATION
INDEPENDENT AUDITORS, REPORT
FOR THE YEAR ENDED 31ST MARCH 2023
Oplnlon
We have audited the finaNial stslem8nts of St Ma￿'S Hosiital Foundation (the 'charitab18 tt&mpany'l for the
year ervJ8d 31 March 2023 which comprise the Statement of Fina￿la1 ACtI￿tIeS, the Balance Sheet.
Stslement of Cash Flows and note8 to the fina￿al statem8nts. incI￿j￿￿ a sunrnary of significant accounting
Ildes. Th8 financial reForting framework that h85 been applied in their p￿paration is applicabbe law WKI
Uni18d lQThJdom Accounting Standards. Ir￿l￿j1￿g FinarKial RepK)rtiny Standartl 102 The Financial Repyting
SlandarLI applicable in the UK and RepuL* oflr8land{Ur¥ted Kin￿kn1 Generalty Actepted Ac￿unting
Practice).
In our O￿nIOn the financial statements:
glve a true and fair View of the stat6 of thè charttabk• compan￿8 8ffalr8 88 at 31 March 2023 aTrJ of if5
income and expondrture for the year then ended:
have been pmperfy prepared in a￿)rdence with Unitod KIr￿d￿n Generalty A￿pted Accounting
Proctice,. and
have been wepared In accordar￿ wllh th8 requirements ofth8 Comp8Thes Ac¢ 20(ffj.
Ba818 of oplnlon
We corKluct8d our OLNJit in a¢xonlanc6 wth Irrtèmatknnal star￿ath on Aud￿ng IUKI IISAS IUKII aThJ
applicable law. Our responsibdities under those staThJards are further descdbed In the Audltorfs
responsibilit￿S for the audh of Ihe flnanclal slat8m8nt8 Se¢tlon of our r8FQrt. Wa arg Indop8ndenl of the
charilabb company in aceordance ¥￿th lh8 @th￿al r8quir8ment8 Ihal are relevant io our audit of th8 financlal
statements in the UK. IndLkllng the Financral R6porliThJ Coundl's IFRCI Ethical Sl8ndard. and we have fU￿lled
Ouf other ethical responsibilitie3 in a(￿)rdance with Ihese requireffents We believe that the audit evidence
we have obta1￿￿19 8ullbd8nt and aF¢Kor￿al6 to rThlde 8 ba￿$ for our opinb)n.
ConcI￿lon* relatbng to golng ¢onurn
In auditing the financial statements. ￿ have 0)nd￿Jed that the trustees, use of the going o)n¢fjm bo￿3 of
xmling in Ihe preparatlon of the finaft¢￿ stslem8nt8 18 apwoptrlats.
8ased on the work we tthi6 perfomiod. we have kJonllfi8d matsrf81 unc8rtalnlo8 relatlng to evonts or
ndltlons thal, in¢Jividu811y or collactively. may cast sl9nif￿nt doubt on the charitable company's gbility ¢0
continue as a golng corcfjm for a pen'od ol at least months Irom when the fin8nd￿ slalemonts arg
authortsod lor I￿U8.
Our r98Fonsit*lities and the Ye8ponsknllttlos of the trwtees *ith re3￿Ct to ￿lI¥j oJn¢em are dexdbed In th•
relevant seclions of thls report.
Other Informatlon
The other inforrnation (x*mpri$88 thg inforni81ion induded in the 8nnu81 report. other than th8 ffinandol
8tatemenls and our auditors, r8port thereon. The Tnjstees are resporrib￿ for the other Infomiation.
Our oplnlon on the finondal slalements does MI cthier the other infomiatlon arnl. except lo the exlenl
otherwise explicit￿ stalod In our report w• do expr•88 any fomi of 888wanc8 conclusion thw8cffl.
In COnn￿li0n our audlt of the financial statements. our ￿3￿nSIbIl￿ is to ￿8￿ ts other information and.
In doSng so. consider whether the other infomialion is malerialty Inex$n￿$tenl vAlh the fin8noal st8tsments or
our knowledge obtsined in the audit or otheThvise appears to te materially misstated. 11 we identify such
material irunsistencies or apparent materlal mi$ststements. we are requi￿ to delemiine vthelher Ihern is
materi81 mis$t8tsmenl in the financial statements or a rnatsrial misstatement of the other information. If.
based on the work we have Ferformed, w6 corrdLMJe that is 8 materi81 M￿sts18m8nI of this othar
informath)n.' we are required to report Ihal
We have nothiNJ to in llis regard.
Pag¢ 22

ST MARK'S HOSPITAL FOUNDATION
INDEPENDENT AUDITORS. REPORT
FOR THE YEAR ENDED 31ST MARCH 2023
Oplnlon on oth•r mattern prescrib•d by th• C(MryMnl•s Act 2006
In our opinion. based on Ihe WO￿ urrfjertsken ￿ the course of ts audit..
the infomialion given in the Trustees. reForf. inGludes the directorn, rewrt Prepared for the
PUT￿ of ¢x)rnP8ny law. for tho fina￿la1 year lor vthich the ffinanc4al statements are prepared 1$
consistent the finanoal statements.. and
the directors, report i￿luded vAlhin Ihe Trustses. re￿rt has bean prBpaTed in &xordance wth
apklicable l¢go1 rgquirements.
Matt•rs on whlch w• ar• r•qulr•d to r•port by •xc•ptlon
In the light of the krK)wleilge and understanding of tho charitat4e compary aTrJ its enwronment obtained In th8
courso of the aLKlil, we have not identsfi8d materiAI rnisstatements in the directors. report included wthin thè
Trustees. r8Kx)rt.
We have nothing to report In T88Fect of IhB follthling matters the Companies Act 2(￿ requiTe8 US to
rewrt to you if. in our OFxnion:
adequats ac￿u￿tir0 re￿1¢58 have been kfjpt. or retum adequate for our aLbJil hove not b8en
rec¥lved from branches not vlslted by us: or
th6 financlal statements are not In agreement with th8 xcounlirwj records aTrJ retU￿ra. or
certain disGto$ures of Tnotees, remuneralkjn B￿cthd bylaw ao rK)t m8de', or
we hov8 not recelved all Ihe Infomwtion 8nd èxpl#rwllon8 wo rw4uiffj for our aL*d￿.. or
the Iru8lees were not entitled to pr8p8re the fi￿ntial stsl¢ments in wth the Small
companles regime arKI tsk8 advantsge of the $m811 compani&s' ex8mptions in preparing the lru8le88'
report and from the roquiremDnl to VeP8ro 8 8trate9￿ rgwrt.
R••pon•lbllltl•s of Tru•t•
A8 explaln8d more fully In tho Trustees. Resp)rnibilitie5 Statement. the Trustees (W￿ are also the directors
ol the ¢harttable company for the purFrf)ses of company Iwl are r&spon$ible for the preparallon of the
n8ncial statements and for being 8aUsfied that they glve a true and 18lr vl8w, an(1 for 8uch intemal control as
the Truslees detsmiine Is necessary lo enabkn the proparalon of financial Btatsmonts that are free from
material misstslemenl. whelhw dug to fra￿j or error.
In pfeporlng thè fln8ndal 8ts1eman18, the Trustees are responslble for a8888slng Ihg charftablè compgnY8
8bS11ty to continue a8 a goirvJ concem, di8clowThJ. as 8ppli¢oty9. matters relatod to golThJ COr￿¢M and uslng
going conc8m ba818 of accounting unless the Trusloes oilher intend lo liqildale the company or lo cease
operallon8. or hava no ro8lith"c altemalive but to do so.
AudltoV• r••ponslbllltl•s lor th• audlt ol th• flnanclal stat•m•nts
Our objeth'ves are lo obtain re8sonable assuran¢8 about vth8th8r the financial stat8m8nts as a whole are fr•e
frorn malerial mis8tstement. whether to fraLKI or erTor. and lo issue an audilorfs report that includes our
oplnlon. Re8sonable ossurarKe is a h*3h level of assur8￿, but is not a guar8nteè that 8n 8LKlit conducted in
accordance ¥￿th ISAS IUKI wll always detect 8 materi81 misstslement when il exisls. Mi55181emonts can
Irom fraud or error arKI are considered malerial rf. irK1ividu81ty or in the aggregate. tlw could rÈ8son8bly be
expected to infiver￿ the &corKJmi¢ ¢Je0$￿n¥ of users taken on the ba￿8 of these fina￿JaI ststements.
Irregulaiili88. Ir￿[l*jing fraud. are instances of non-tx)mrAlance with laws and wulalions. We dèsign
procedures in line w7lh our rBsponsibilities. ouUin•Y atrthfg. to detect material misststsmenls In respect of
irregularities. indudirvJ fraud. The extent to which our procedures are capatde of detsctirwJ irregu18ritie8.
Icludlng fraud is detailed tr*k)w'.
The Charitable Company is required to comFty with o)mpany law and ch8rity law and, based on
our kno¥￿edge of its actNities. we identified that the legal requlrgment lo a￿urd1efy account for
restricted funds was of key s1gntrKan￿.
Pag¢ 23

ST MARK'S HOSPITAL FOUNDATION
INDEPENDENT AUDITORS. REPORT
FOR THE YEAR ENDED 315T MARCH 2023
We gained an undersl8rKling of how the charitsble cornpany wmFAied vAth its legal and regulatory
framework. includi￿J the requirementto propedy account for rnslricted fijnds. thrOL￿h discussions wllh
management and a review of the documented pdIc￿s, Pro￿dureS and controls.
The audit 188m. which is experienced in the 8￿jrt of thanb"es. considered the charTt8ble company's
susceptibility to material mi5Staternent and fraud may occur. thJr con5thrallons included Ihe rfsk
of management override.
Our 8pproach was to ¢heo* thal all re8lrthd irK£4ne vras F￿Operty idènknfi&l and 8epargtsly accounl8d
for and lo ensur8 that only valid and apKwopriate expenditure was chary￿ to restricled funds. This
Induded reviewing ioum81 adjustments arnl unLL8ual tranSaC￿n8.
A fijrther doscription ofour responsitsliiies fDr the audit of the fina￿al statements18 locatsd on the FInar￿181
Reporting Councll's website at.. www.frc.or
.uklaudil
ibilities. Thi8 desCripl￿ft fomis part of our
audilorf8 r6Wrt.
ot lh• audlt r•port
This report is made solely lo th8 charits￿e componY$ members. as a body. In accordance wth Chapter 3 of
Part 16 of the Companies Act 2006. Our audit WO￿ ha8 been uThJortaken. so that we might slate to th8
chorilable company's MeMt*￿ IIKJSO matterB are Tequired to stale lo Ihem in an audil0rf8 rO￿rt arKI for
no olher purpK$8e. To the ful￿3{0X18￿I permitted bylow, ￿ do rwl a￿¢pl or assume Te3w)nsibility to anyong
other Ihan the charftatrAe company arKI the charitsble ¢ompaWs memb8TS 88 a body, for our audit work. for
this report or for tho opin￿n3 we have fom1￿.
14 Dec 2023
Slm4)n Goodrldg•
S•nlor Statutory Audltor
for and on b•half of Knox Cr¢)pp•r LLP
Statutory Audltorn
65 L•ad•nh•ll Str8•1
London EC3A 2AD
Page 24

ST MARK'S HOSPITAL FOUNDATION
STATEMENT OF FINANCIAL ACTMTIES
(INCORPORATING THE INCOME AND EXPENDITURE ACCOUNT)
FOR THE YEAR ENDED 318T MARCH 2023
Noto Unrestricted Dosignated Restridod
Funds
Funds
Funds
Total
Funds
2023
Total
Funds
2022
Income and Endowmwrts
Donallons and Legaci88
Investment Income
Income from Charitable
Activities.. Education c￿r5eS
Other Incoming Resources
839.484
19.694
1.142.145
1.981,629 1,283,887
19,694
2,458
,445
37.575
103,488
544,020 375.469
103,488
61,039
Total InGom• and Endv*m•nts
1365.623
1283 208
1648.831 1.722.853
Expgnditur•
Costs of Raising F￿d3
Charitable AclMIi8s
235.783
667,063
157
1,216,115
235,940
182,793
2.037,384 1.658,395
154,J
Total Exp•ndituro
902.846
2 273 324 1,841,188
Not Incomol{Expgndltw•)
462.777
{154.2￿)
66.936
375,507 (118.3351
Transfers between funds
N•t Mov•m•nt In Fund•
12113
214,800
247,977
166 372
12.166
48,428
115,364
375.507 {118,3351
Balanco at 111 Aprfl 2022
8alanc• at 31•1 March 2023
614,219
546.528
2,743,281
3.904.028 4,022,363
862.196
S58.694
2.858,645
4.279,535 3,904,028
Pa8¢ 25

ST IAARK'S HOSPITAL FOUNDATION
BALANCE SHEET
AS AT 31- W4RCH 2023
2023
2022
Flxed Assots
Tangible Assets
Curr•nt Au•ts
Debtors
Nottt deFosits
Cash at bank and in hand
10
15
15
540,375
400,000
6n.027
4,611402
201.552
9￿,c￿0
2,989.214
4.090,788
Creditor8'. Arnunls f8llhw d
within ono year
11
333.887
186.738
Net Curr•nt As••ts
4271335
3.904,028
Not A•••ts
4,279.$38
3.904.028
Fund•
Re8lrlcted
De8ignated
Unrestnct8d
13
12
2.858.846
558.694
882.198
4.279.535
2,743,281
S46.528
814,219
rotal Fund•
3,904,028
The8e fin￿claI ￿&tem￿s 8Fprov&l ty the Tru8tee8 on
behalf by
l• L38nd slgned on thefjr
Sr Tlx)ma$ TroubThlg•
Company Numtér. 07532184
Page 26

ST MARK'S HOSPITAL FOUNDATION
STATEMEKf OF CASH FLOWS
FOR THE YEAR ENDED 31ST MARCH 2023
2023
Statemont of Cash Flow
2022
Cash flows from opornting actlviti8•:
Net c¥•h
ovldèd
s•d In
Cash flows from investing activities..
Divid8nds. interest and rents from iiveslments
Proceeds of sale of investrnents
N•1 cash provldod by Inv•stlng acdvltl•8
actlvltl•s
549.805
19,694
2.458
19.694
2.458
Cash flows from fimncing actlvlti•8
Nel cash
rovided b I
used in
rinanryn
activiti88
Change In cash and cash equival•nts In the reporting perlod
Cash and cash •quival•nts at th• *inning of th• r•porting p•rlod
Cash and cash •
ulval•nts •t th• •nd of th• r•
rtln
od
183.813
552,263
3,889.214 3,336,951
4 073.027 3.889,214
Reconclllatlon of P4•t IExpendlturoVlncomo to Not Cmh Flv* from
Operatlng Adlvltlés
2023
2022
Nel Incom8llexp8ndilurel for Ihe ￿￿tir￿d wriod (a$ per the statement
of financial aclivit5esl
Adjustments for.
Depreclalion charges
Losses on investments
Dividends, intere51 and r8nls Irom investments
Decreaselllncreasel in debtor8
Increasel
Decrease
in Creditors
Net cash
rovlded b I
used In
375,507 1118.335)
119.6941
1338,8231
147.129
164.119
12,458)
644,105
26.493
549.805
atln
acti¥ltlo8
An•lysi• of Cash and Cash Equiv#lBnts
2023
2022
Cash in hand
Notice de
sils
Total cash and cash equivalents
673.027 2,989,214
3.400.000
0,000
4,073.027 3.889.214
Page 27

ST MARK'S HOSPThAL FOUNDATION
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 318T MARCH 2023 {contlnuedl
ACCOUNTING POLICIES
{al
Ba8is of Prgparatlon
The financial statements have bsen prepared Ni accordance wilh Accounting and
Reporting by Charities: Slatemenl of Rècommended Practice applicable to charities
preparing their account5 in accy)rdance wlh the Financial ReFQrting Stsndard applicabl&
In the UK arKI Republic of Ireland IFRS102) (second edits'on - October 20191 and the
Companies Acl 201￿. The dwrity conslitutes a public be￿rrt entlty as defined by FRS
102.
Crltlcal accounting •stlmates and ar•as of Judgoment
Preparation of the financial statements requires the Truslges and manag8m8nl to mak8
Signlficant judgements estimates.
The items in the ffinanclal statements where th888 ludgem•nts and 8stimales have been
made include:
Assessing Ihe probability of receipt of legacy income:
Determining the apportionment of expendituro be￿￿en the Categ￿￿9 of
expenditure on charitable activit￿$.
Ic)
Golng ¢onc•rn
The Trustees have assessad whether the use of the going concern assumptson 18
appropriate in preparing these financial slalemenls. The Tru51ets have made this
assessmgnl in respect lo a period of one year from lh8 dale of approval of these financial
statements.
The Charity remains a going concern. Pro￿dad there are suffKient Unrastricled Reserves
lo meet thè charity's oFeraliThJ expendlture lor the foresgoabbe future. At 31 March 2023
the ¢harfty had the equivoienl ofjust under ts¥elve months, operating expendiluTg in
unrestricted restsrves {£862.1961. Forecast ¢ash flows for 12 months from the dale of this
report inditste that these Unrestricted Reserves will be $uffi¢ient to meel opgrating
expenditu￿.
Accordingly the Trvstees of the ch8nty have ¢ondud8d that there no m8lerlal
ncertainlies related lo events or corKlitions that may cast significant doubl on the abilty
of the chanty lo continue as a going ¢oneem. The Trustees are of the opinion that the
Charty will have sufficient rosources lo meet its liabilities as they fall due.
Id)
Research Expendlturn
Liabilities are recognised as resource$ expaThJe(l a$ sty)n as there is 8 legal or
constructive obligation committing the charity lo the expendtture. All expenditure is
accounted for on an aecTuals basis and has been dassified under headings that
aggregale all costs related lo ￿ category.
The expendlture is accounted for vthere either Trustees have agreed lo pay wllhoul
condit￿n and the recipient has a ￿aSOnal￿e expedalion that they will recèive an award.
or any condit￿n attaching lo th8 expgnditure is outside the control of the Foundation.
Page 28

ST MARK'S HOSPITAL FOUNDATION
NOTES TO THE ACCOUNTS
8T
FOR THE YEAR ENDED 31 MARCH 2023 (continued)
ACCOUNTING POLICIES IcoDtinu•d)
(•)
Tanglbl• Flx•d Ass•t• and Dyeclatlon
All assets costing more than £1.(M)O are capitalised and all assets are valugd at historic
cost. Depreciation of rued assets is calculated on ￿st at rates estimated to wrfle off thg
assets. by @qual instalmonls. over th￿"r 8xpectod working lives. Fixtures and fittings and
office equipment are written off over five ￿ats. Computers are written off over three
years. The mrAlular building wa5 depreryated over fwr years.
Incom•
Researd) funding in¢orro is recognised in the year in which th6 charity receives a wdllen
commitment Irom the fuThJer. Research fundiTrJ is deferred only when th8 charity has lo
fulfil conditions before becoming entitled to il or donor has speclfied that the Income
ha$ to b6 Spent in a futwo poriod.
All other Incoming resources are included n the Statement of Flnancial Activiti08 ISOFAI
when the FoUndat￿n 15 legally entr"tlg(I lo tho in¢crfng and tho arTvJunt can be quantlfled
with ffja$onablé accuracy.
(gl Value Add•d Tax
The Fount18lion regislered for VAT from Augusl 2019. appIl￿ble. all costs and
expenditure incurred on tradlng actlvilies are exthsw of VAT.
(h)
AlloG*lon of Support C￿ts
Support ￿St5 have been allocated be￿een charftsble actlvllles and fvndralslng. Support
costs Telating lo Charitab￿ activilies have been apportioned based on a welghled salary
porconlago basis. Tho ailo¢•bon of 8UPPOrt costs is analysod in note 6.
Co•t8 of Ralslng Fund¥
The cost ol generatiThJ and administgring voluntary incom8 indudes fundraising costs.
invoslm8nl managers, fees and a proportion of staff costs.
ti)
Ch•rltabl• Actlvltle•
Costs of tharitable activths indude grants made and an apportionment of overhead 8nd
support costs as shown in nole 5. 0￿rhead L7>sts are apportioned based on the staff time
spent on the charitable acliwlies.
Ik)
Funds
Unreslrfcted funds are funds whic* can b8 used al ￿ Trustees, dkcrelh)n. Restricted
Funds are funds wtK)se purposas have bgen rgstricled by the donor. Oesignalad Funds
are unrestri¢led funds which have been eamarkad by Iho Tnjstees for parts'cular
Purposes.
Volunlary Incom•
Unrestricted
Funds
Restricted
Funds
2023
2022
Donations and Grants
Legacies
316,731
522.753
839,484
892,145
250.CKXI
1.142.145
1,208.876
772.753
1,981.629
1.035,610
248,277
1,283,887
Page 29

ST IAARK'S HOSPITAL FOUNDATION
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 3191 MARCH 2023 {contlnuedl
Invfrstm•nt Income
2023
2022
Bank Interest
19.694
19.694
2,458
2.458
Exp*ndlture on Ralslng Funds
Unrestrlcted
Funds
Rostrlcl•d
Funds
2023
2022
Fundfaising Costs
Governance Costs
Ovetheads
Staff Costs
59.398
4,386
22.098
149,901
235.783
157
59.555
4,386
22,098
149,901
235,940
29,575
3.618
12,896
136,704
182.793
157
Analys1• of Charltable Actlvlll••
Olr•¢t
Expendfturfr
Support
Costs
2023
2022
Research Expenditure
Education
1,388.713
479.425
1.868.139
115,929
53.317
169.245
1.504,643
532,742
2.037,384
1.342,808
315.587
1,658.395
Unr•strlcted D•slgnat•d R•strlct•d
Funds
Fut￿*
Funds
2023
2022
Dlr•ctly In¢urr•d
Re<harg8d Salanes
Equipment
Expenses
Salaries
Courses
27.654
521.551
549.205
421,118
174,000
600,451
153.843
154.121
1,503,533
21,548
184,056
321,448
527,052
124.135
861,494
807.177
184,056
327,701
1.868,139
6.253
1.189.298
151.789
Support Costs
SalaTies
Legal & Professional
Audit & AccountanGy
Other Costs
115.307
26,817
142,124
135.123
629
3.212
20,546
140.011
3,212
22,963
169.245
2.417
2.417
26.817
154,862
Total Ex
ndlturo
154.206
1.216 115
2.037.384
1658,395
Page30

ST MARK'S HOSPITAL FOUNDATION
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 31ST MARCH 2023 (continu•d)
Expenditure
Research
Education
Fundrnt8lng
2023
Dlr•ctly Incurred
Re-charged Salarle5
Equipment
Expenses
Salaries
Courses
549.205
549,205
762,947
76.$62
807,176
184.056
327.702
1,868,139
107.494
327.702
479.425
1,388,713
Support Co•t•
Salarles
Legal & Profes$M)nal
Audit & Accountancy
Other Cost$
Fundraisi
96.703
45.421
302
1,027
149.901
292,025
1,944
6,600
45.062
59,555
405.186
2,186
16.396
3,387
22.098
59.555
235.940
Costs
115.929
53.317
T¢)tsl Ex
•ndStur•
1,504,642
532,742
235,940
2.273,324
Ru••r¢h
Educatlon
Fundrai•ing
2022
Dlr•ctly Incurr•d
Re-charged Salarie8
Equipment
Exp9nse$
Salaries
Courses
421.118
174,000
570.667
71,417
421.118
174.0(KJ
600.451
153.843
154,121
1,503,533
29.784
82.426
154.121
266.331
1.237.202
Support Costs
Salaries
Legal & Professional
Audit & Accountancy
Other Costs
Fundraisin
91.176
424
1.989
12.017
43.947
204
959
4.146
136,704
636
2.982
12,896
29,575
182.793
271,827
1,264
5,930
29.059
29.575
337.655
Costs
105,606
49.256
Total Ex
enditur•
1.342.808
315.587
182.793
1,841.188
Page31

ST MARK'S HOSPITAL FOUNDATION
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 31ST MARCH 2023 {contlnued)
N•t (Exponditureyln¢Thn•
2023
2022
N91 {Expendilureylncome for the year is stated after dwrging..
Auditors. r8muneration for audit sefvKes
6.600
5.930
Staff Costs
2023
2022
Direcuy Employed Staff..
Salary Costs
Social Security Costs
Pension Contributions
412.501
43.082
20,497
476,080
363,290
36,523
18.733
418.546
7,124
425,670
S18ff seconded from Northw881 London Hospitals NHS Trust
476.080
Average number of employees duriTrJ th8 year.
Full-tlme
Part-time
None of the omploye8S' totsl em01￿ments tel within the £90.OCM)4100,000 band In th6 yoaf lone In
2021-22). Total gmolumenls for one 8mployg9 fell within the £100,CQO4110,000 band In th8 year
Inone in 2021-221. The total remuneralh)n of the three key manag&menl personnel for the year wo$
£152.8251£148,134 three key personnel in 2021-22). The above disclosures relate to
eslabltshed posts.
D&tails of the Trusle8s' rernunerat￿n are dealt with in note 15.
Tanglbl• As•ots
Land and
Bulldlngs
Fixturgs Softwar•
and Flttlng•
2023
2022
Cost Brought Forward
Addibons
Cost Carried Forward
235,000
3.499
10,584
249.083
249,083
235,0￿)
3.499
10.584
249.083
249,083
Depreciatson Brought Forward
Charge for Year
Depreciation Carried ForyRrd
Nel Book Value rjf
Net Book Value bff
235.IXKI
3,499
10.584
249,083
249,083
23S.LM)O
3,499
10,584
249,083
249.083
The land and buildings reprnsenl a prefabricated building funded by St Mark's Hospital
Foundation which is used by St Mark's Hosprtal. Sl Mark's HOs￿'t81 Foundatlon has Th)
responslbilty for losses or damages in respect of this building.
Page 32

ST MARK'S HOSPITAL FOUNDATION
NOTES TO TIIE ACCOUNTS
ST
FOR THE YEAR ENDED 31 MARCH 2023 Icontinuedl
10. Dobtors
2023
2022
Tax Recoverable
Prepayments
Accrued Legacy Income
Other Debtors
1,234
157.677
89.641
291.823
2.760
71,175
127,617
All amounts 1811 due WIt￿n one year.
540,375
201,552
11. Crndltorn: Amounts Falling Dw wlthln One Year
2023
2022
Accruals and Deferred Income
0th8r Creditors
121.388
212,479
48.025
138,713
333,867
186.738
Increase in creditors is largely due to the arxfued costs, billwj after the financial year end.
12. D•slgnat•d Funds
Balanc•
BIF
8alanc•
CIF
In¢om• Expènd1￿10 Transf•rn
Chairman's Action Fund
Dean's Fund
Nurse Edu&2tiM Fund
Endoscopy+
Seedcorn Fund
(1.3381
{2,4181
{2801
3.662
6,376
46,515
150,000
352,141
558.694
8,794
34,543
12,252
150,000
498,191
546.528
150 170
(154.206)
166,372
Trustees have designated the unrnslricted funds:
Tho Chalrman's Actlon Fund financ8s discretionary rKojecl8.
Tho Dean's Fund finances genoral research.
Thè Nur8• Educatlon Fund finances projects for student nurses.
Endoscopy+ finances upgrade of the endoscopy uniL
The Seedcorn Fund indudes cost of financing projects al new hospital sile. including MDT room.
Page 33

ST MARK'S HOSPITAL FOUNDAnoN
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 31ST MARCH 2023 {continuodl
13. Rostrlctsd Funds
Restricted funds compdse the followng unexpended balances of donauons and grants given for
specific purposes:
Balance BIF
Incom• Expendltur•
Transf•rs Balan￿ CIF
IBD Researth
Surgical Research
Radiology
Wowson Endoscopy Unlt
Flex Surgery
Psychologieal Medicine
Colorfjclal Cancer Research
Medical Nutn'lion
Virtual Colonoscopy
Colorectal Can¢er Unit
Gastroenterology
Sl Mark's Oigilal Channel
Nurse Educatlon & Research
Pathology
Polyposis
Enhanced Recovery
St Mark's Ass￿••lIon
Other
494.892
447.437
325.934
290,697
243,194
226,652
214,238
145,472
65.249
59.733
59.379
35.422
20,915
19,695
19,040
10,303
8,264
192,494
25.761
462.398
{277,691)
(88,977)
{404.1201
194.7851
{39,339}
13,595)
3,191
406,100
387.412
384.212
244,102
203,855
226,652
410,943
168,721
35,353
46,604
192.607
35.422
25,089
19,695
8,781
10,303
9,344
43,449
(2LN)I
321.045
(124.340)
116.286)
(28,6961
(12.7101
{74.4931
37,726
11.200)
14191
1,024
2C6,697
2,758
(3,556)
4,972
9.833
(20,111)
19
7,775
4.247
16,8451
24,323
150
2022-23
1283 207
272
2021-22
2,614.273
970,278
869,516
28,246
2,743.281
Transfers r8presenl movements boknn restricted fund balances, transfers from designated funds
and Iranslgrs of St Mark's Acadomie Instilule course profits to convenors, proje¢ts. The larger
transfer into the Medical Nutribon lund above represents the course profil share from St Mark's
Acadamic Inslilute.
Movemgnts between restrictod fund b81ances are tho movement of funds Th)1 sp8dfically r8strict•d
to one p8rtlcular group of r•search or edwation to support new or orwing restricted projects.
Page 34

ST MARK'S HOSPITAL FOUNDATION
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 31ST MARCH 2023 Icontinuad)
13. R•$trlctod Funds
The psjrposes of the FurKis we as follows..
IBD Research - for research into all forms of inflammalory bowel disease
Surglcal Research - for general surglcal research & edU￿tion
Radiology - fof research & education in that department
Wolfson Unit for Endoscopy- for research & edUCat￿)n in that department
Flex Surgery- minimally Invasive surgical technique
Psychological Mediane- for research into patient psychology
Colorectal Cancer Research- for research & edUcat￿n in that department
Medical Nutrition- for research and education in that department
Virtual Colono$¢opy- for research into Improvements to eolonoscopy proceduies
Colorectsl Cancer Unit- for research & education in that departsnenl
Gaslro8nlerology- for research and e(lucalion in th81 department
st Mark's Digital Channel - lo devek)p we￿based platform to showcase the innovalrve
and unique allribules of St Mark's Hosprtal.
Nurs8 Education and Research- to support training
Pathology - for research in Ihol department
Polyposi$ - for reséarch & educ8t*)n in the Polwis Registy
Enhanced Recovery- for research in that deparlmenl
Sl Marks Association
to maintain and devebop links between current dinieal and
academic staff of St Mark's HO$￿1, and th0$6 who have wevloLtsly worked with the
hospllal
Other - indudes funds relaled lo surgery, pouch research, physiobgy, COVIO. Burd8tt
Nurslng Sthobrship Prc*Jramme and sloma Care prdacts
14. Unr•strlct•d Fund•
Balance
BIF
Balanc•
Incom• Exp•ndltur• Trnnsf•r• 8ub•ldy
St Mark's
Academic In$lilut&
Foundation
<527,052) (51,0901
71.697
614219 859 178
375 794
71,697
614219 1,365,023
902,846
214,800
862,196
15. Analysls of As8•ts and Ll•blllll•s botw••n Fund•
Unr•strlct•d R•strlcl8d
and
Funds
Designated
Funds
Total
2023
Flxed Assets
Current Assets..
Debtors
Notice DeFKJSits
Cash at 8ank and In Han
Llabilities
419.146
1,128,866
37,316
(164.438)
121.229
540,375
2,271,134 3,400.000
635.711
673,027
(169,429) 1333.8671
Page 35

ST MARK'S HOSPITAL FOUNDATION
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 31ST MARCH 2023 l¢ontlnuod)
1.420.890
16. Trustees, Remuneration and Exponses
2.858,645 4.279,535
remuneration. dlreclly or irmlirecty. oul of the funds of the Foundation was paid or payable for
th8 y88r to any Trustee or lo any person or persons known to be connected with any of them. No
expenses were reimbursed to any Trustee Other than costs paid on behalf of the Foundation and
subsequenlty recovered.
17. Pemlon S¢h•m•
The Foundation offers Membership of the NEST pènsion scheme to its employees. matching the
Contributions made by the employees up lo a maximum of 6% of earnings. The Foundation also
makes conlributh)ns inlo Ihe personal pension schgmes of three employees: conlnbulion rale
for both the employee and the employer is 6%.
18. Taxation
Sl Mark's Hospital Foundats'on is a registered charity and is exempl from taxation in respect of
income and capit81 gains to the extent that such income or gains are applied to exdusively
charitable purpose$.
19. L•a•• Commltm•nts
On 29 March 2018. the Foundation entered into an agreemenl *ryth Inluliiv8 Suryical Limlled
I'lnluilive") to rent a surgical robot, the da Vinu Xi Surgical System Dual Console, for a period of
26 months. Under the tems of tha agreement. the FourKlalion made rentsl payThgn15 aggregating
£520.000 until May 2020. A moratOTium of payments was agreed for six months whilst the Robot
was not in use due lo COVID-19 crisis. The Foundation signed a new agreement for the rental of
the Robot on the Str October 2020. which came lo an eTrJ on 31 December 2021, with the total
value of £304,000. The Foundalion endod ils agreement with the supplier on 31 Dgcembèr 2021
and consequently, has no ongolng financial or r￿traCtUal inleresl in the robol.
The Foundalion also has a cornmilment under a lease agregment lo pay annual charges of £3.024
12022 £3,024) on other office equipm8nL This was renthved in May 2020 for a further five y6ars.
The total minimum108$8 payments due ovor tho lease term..
2023
Ouo Data
Within 1 year
Within 2-5 years
3,024
3.024
3.024
6,048
20. R•lated Party Tran$actlons. There were no Related Party Transact￿)n$ during the year.
Page 36

ST MARK'S HosprrAL FOUNDATION
NOTES TO THE ACCOUNTS
FOR THE YEAR ENDED 31ST MARCH 2023 (contlnu•d)
Refaronce and Administrative Infomiatlon
Charity Number
1140930
Company Number
07532184
Registered Offiee and
Operational Address
St Mark's Hospital, Watford Road, Harrow HA1 3UJ
Trust888
The Truslges. who are also directors under wmpany law.
who served dunng the year and LSP to the dale of this report
{unless slatéd olheTrvlsel were as follows..
Sir Thomas R Tr￿Jbridge (Chairl,.
Catherine Boardman,. (Retired 8th J￿& 2022)
Prof Susan Clark3 {Appoinled 8￿ June 2022)
Andrew Lat¢hford
Moni Mannings
Sharad Rathke (Treasurer} .
Gillran C Tayk)r (Rétired 14Ln Decem￿r 20221
Margaret Vance {Appoint8d 30* March 20231
Secretary
Mak8 Phulkaradzo
CEO
Jason Bacon
Medlcal Director of Sl Mark's Howtal
Prof Omar Faiz I Carolynne Vaizey
Dean of the Sl Mark's Atsdemic Institute
Prof Allsa Hart
AC￿un￿nI
Makg Phulkaradze
Audhors
Knox Cropper LLP. Ch8rtered Aco)untsnts
65 Leadethall Street. London EC3A 2AD
Bankors
Cafcash Lhntted
lfjrrfJs Hill, Wesl Mallirvj
Kent ME19 4TA
Lloyds 8ank plc
25 Moorgale,
London EC2R 6AY
Pa8¢ 37