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Trustees’ Annual Report for the period

From 01.01.24 To 31.12.24

Charity name: HEALTH SECURITY, INNOVATION AND SYSTEM REFORM

Charity registration number: 1136879

Objectives and Activities

	SORP reference
Summary of the purposes of the charity as set out in its governing document	Para 1.17	Health Security, Innovation and System Reform’s main activity is to promote evidence-based research, services and efforts for the public benefit in all health-related areas. The purpose outlined above is achieved through collaboratives, communication, education and Health Research & Scholarships.
Summary of the main activities in relation to those purposes for the public benefit, in particular, the activities, projects or services identified in the accounts.	Para 1.17 and 1.19	Main activities include supporting and informing global collaborations involving distinguished decision- makers and influencers from across the World. Consider practical, lasting and innovative solutions and efforts that focus on global healthcare challenges. Support and commission work programmes which seek to address and help raise the profile of global health and security issues.
Statement confirming whether the trustees have had regard to the guidance issued by the Charity Commission on public benefit	Para 1.18	Yes

Additional information (optional) You may choose to include further statements where relevant about:

	SORP reference
Policy on grant making	Para 1.38
Policy on social investment	Para 1.38
including program related
investment
Contribution made by	Para 1.38
volunteers
Other

Achievements and Performance

	SORP reference
Summary of the main achievements of the charity, identifying the difference the charity’s work has made to the circumstances of its beneficiaries and any wider benefits to society as a whole.	Para 1.20		Who We Are Through a variety of methods, we provide access to a global healthcare community dedicated to capturing and disseminating the best evidence-based ideas and practices. Our vision A healthier world through global collaboration, innovation and shaping to evidence-based policy. Our mission • We forge connections and help build action-driven communities of knowledge who work together to address today's most pressing global healthcare challenges. • We convene and collaborate with the world's leading experts and the highest levels of decision-makers. • We create and disseminate world-class, evidence-based content and knowledge. • We promote active learning and support within and between communities. • We aim to influence healthcare policy globally and improve health outcomes. Activity WISH– World Innovation Summit for Health WISH 2024 – Humanising Health: Conflict, Equity and Resilience. Supporting the influencing policy at a local, national and international level reports were published in the 2024 summit - on several areas relevant to health security including: • Protecting health in armed conflict • Innovative solution for elimination of TB amongst refugees and migrants • Tackling AMR – how to keep our antibiotics working.

Health Security Tackling Antimicrobial Resistance (AMR) Building on the work in 2023 we have been involved in progressing the work focused on addressing the challenge of AMR – the Fleming Initiative. Supporting partner organisations Imperial College and Imperial College Healthcare NHS Trust in their endeavour to structure and launch a novel programme of work. To effectively tackle antimicrobial resistance, global awareness and behaviour change is needed alongside scientific advances. Building on the historical legacy of Fleming’s discovery of Penicillin in UK, the aim of The Fleming Initiative is to put society at the heart of solving this problem. Activity during the year was centred around: • Targeted programme of work to support fund raising activity supported by a experts. • Development of dossiers and content to to support fundraising and wider awareness raising for the initiative • Identifying partners and supporters and fundraising effort • Working with specialists in philanthropy and other experts from industry and health sector. • Developing international partnerships The Fleming Initiative will be a global effort with an inaugural centre in London, where Fleming’s discovery happened in 1928. In July 2023, HRH The Prince of Wales became the Patron of the Fleming Initiative. Supporting Health Education in Ukraine Funding was given to support the delivery of remote learning for healthcare students and clinicians in Ukraine and the delivery of healthcare in extremely challenging circumstances. Medical Examination equipment and equipment to help enable remote monitoring and consultations were procured.

Additional information (optional)

You may choose to include further statements where relevant about:

Achievements against Para 1.41 objectives set Performance of fundraising Para 1.41 activities against objectives set Investment performance Para 1.41 against objectives Other

Financial Review

Financial Review
Review of the charity’s financial position at the end of the period	Para 1.21	The charity currently has funds of £2.02m.
Statement explaining the policy for holding reserves stating why they are held	Para 1.22	Our reserve policy is based on ensuring the financial security of the charity. The policy is to retain a reserve of approximately 80%.
Amount of reserves held	Para 1.22	£2.02m
Reasons for holding zero reserves	Para 1.22	N/A
Details of fund materially in deficit	Para 1.24	N/A
Explanation of any uncertainties about the charity continuing as a going concern	Para 1.23	N/A

Additional information (optional) You may choose to include further statements where relevant about:

The charity’s principal sources of funds (including any fundraising)	Para 1.47
Investment policy and objectives including any	Para 1.46	The charity has an ethical investment policy whereby we do not invest in alcohol, tobacco, pornography and military focused companies. Our

social investment policy adopted		investment is managed through an SRI fund from Newton Investment.
A description of the principal risks facing the charity	Para 1.46
Other

Structure, Governance and Management

Description of charity’s trusts:
Type of governing document (trust deed, royal charter)	Para 1.25	TRUST DEED
How is the charity constituted? (e.g unincorporated association, CIO)	Para 1.25	Trust, unincorporated
Trustee selection methods including details of any constitutional provisions e.g. election to post or name of any person or body entitled to appoint one or more trustees	Para 1.25	By appointment

Additional information (optional) You may choose to include further statements where relevant about:


Policies and procedures adopted for the induction and training of trustees	Para 1.51
The charity’s organisational structure and any wider network with which the charity works	Para 1.51
Relationship with any related parties	Para 1.51
Other

Reference and Administrative details

Charity name	HEALTH SECURITY, INNOVATION AND SYSTEM REFORM
Other name the charity uses	HSISR, HISR
Registered charitynumber	1136879
Charity’s principal address	10thFloor, ASU, QEQM Building St. Mary’s Hospital South Wharf Road London, W2 1NY

Names of the charity trustees who manage the charity

1 2 3 4 5 6 7 8	Trustee name	Office (if any)	Dates acted if not for wholeyear	Name of person (or body) entitled to appoint trustee(if any)
	Professor the Lord Darzi of Denham
	Mr. Gianluca Fontana

– Corporate trustees names of the directors at the date the report was approved

Director name None

Name of trustees holding title to property belonging to the charity

Trustee name Dates acted if not for whole year None Funds held as custodian trustees on behalf of others Description of the assets held in this capacity N/A Name and objects of the charity on whose behalf the assets are held and how this N/A falls within the custodian charity’s objects Details of arrangements for safe custody and segregation of such assets N/A from the charity’s own assets

Funds held as custodian trustees on behalf of others

Additional information (optional)

Names and addresses of advisers (Optional information)

Type of	Name	Address
adviser

Name of chief executive or names of senior staff members (Optional information)

Exemptions from disclosure

Reason for non-disclosure of key personnel details

N/A

Other optional information

Declarations

The trustees declare that they have approved the trustees’ report above.

Signed on behalf of the charity’s trustees

Signature(s) Full name(s) Position (eg Secretary, Chair, etc) Date

HEALTH SECURITY INNOVATION AND SYSTEM REFORM (Charity Number 1136879) Accounts for the year ended 31 December 2024

Contents: Page 1 Balance Sheet Page 2 Statement of Financial Activities