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2021-12-31-accounts

Registered charity in England & Wales111368091 and in Scotland ISC0467351 Registereé in England & Wales Company number.. 07278507 Reverse Rett Report and financial ststements for the year ended 31 December 2021

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Reference and Administrative details for the year ended 31st December 2021 Company number 07278507 Charity number 1136809 (England & Wales) and SC046735 (Scotland) Registered office and operatlonal address: Statham Link Suite IF Lancastrian Office Centre Talbot Road Old Trafford Manchester M32 OFP TrusteeThrustees, who are also directors under company law, who served during the year and up to the date of this report were as follows: John Sharpe Chair Helen Simmonds Wice-chair Dr Ruksana Ahmed- joined 07.07.21 Andrew I Stevenson Rachael Stevenson ortensia Martinotti Catherine McKinney Kate Mcmaster Rita Ross Neil Buckley -resigned 25.03.21 Joanna Snyder Mwangala ￿shomwa joined 04.05.21 *Tru5tees who are also Directors of the charitable company. The number of guarantee members is 11. Key management. Rachael Stevenson CEO Bankers. Barclays Bank 102 High Street, Thame, Oxon, OX9 3DU Independent auditors Slade & Cooper Limited, Beehive Mill, Jersey St, Manchester, M4 6JG

Reverse Rett Trustees. annual report For the year ended 31st December 2021 The trustees present their report and the audited financial statements for the year ended 31 December 2021. Included within the trustees. report is the directors. report as required by company law. Reference and administrative information set out on page I foms part of this report. The financial statements comply with current statutory requirements, the memorandum and articles of association and the Statement of Recommended Prartice - Accounting and Reporting by Charities.. SORP applicable to charities preparing their accounts in accordance with FRS 102. Objectives and activities Mission Reverse Rett is a patient advocacy and research organisation focused on delivering treatments and a cure for Rett Syndrome to everyone affected. Objects as set out in the charl￿$ governing document Reverse Rett exists to relieve sickness and to preserve health for the public benefit by developing treatments and cures for Rett Syndrome and related MECP2 disorders, in particular but not exclusively by: Funding laboratory and clinical research projects Advocating for ac￿55 to treatments and therapies for all affected patients Disseminating research and health infomation In(￿asIng general public awareness and knowledge of Rett Syndrome and related MECP2 disorders. Main activities undertaken in relation to objects Children and adult5 Wlth Rett Syndrome are at the heart of everything we do in line with our mission to deliver treatments and a cure to everyone affected. Four vital pillars underpin our work: l. Research We fund research projects that will lead to better outcomes for children and adults with Rett Syndrome both now and in the future. 2. Advocacy We advocate for access to treatments and therapies for all affected patients. 3. Outreach We increase public awareness and knowledge of Rett Syndrome and related MECP2 disorders so that we can register and contact afferted patients who may benefit from emerging treatments.

Reverse Rett Trustees. annual report For the year ended 31st December 2021 4. Clinical care We improve clinical care and outcomes for complex UK children and adults with Rett Syndrome whilst disseminating research and clinical best practice information to improve management of all those affected. Publlc benefit The trustees review the aims, objectives, and activities of the charity each year. This report looks at what the charity has achieved and the outcomes of its work in the reporting period. The trustees report the success of each key activity and the benefits the charity has bmught to those gmups of people that It is set up to help. The review also helps the trustees ensure the charity's aims, objectives and activities rernained focused on its stated purposes. The trustees have referred to the guidance contained in the Charity Commission's general guidance on public benefit when reviewing the charity's aims and objectives and in planning its future activities. In particular, the trustees consider how planned activities will contribute to the aims and objectives that have been set.

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Activities and projects I. CIPP Rett Centre. King's College London. £315.836 {includes note 2. below £12.000) Reverse Rett provides core funding for the CIPP Rett Cent￿, the UK'S only Rett Syndrome clinical treatment and research Centre based in South London at the Maudsley Hospital and King's College London and led by Professor PJ Santosh. The CIPP Rett Centre focuses on developing digital health strategies to monitor and manage patients whilst condutting translational research using the HealthTracker platform, providing holistic specialist Ca￿ and condurting clinical trials. Reverse Rett has committed to providing core funding to the CIPP Rett Centre at a cost of £998,000 over three years from September 2019-September 2022. In March 2022, subsequent to a formal review of the Centre's activities, the Board of Trustees of Reverse Rett voted to extend funding for the Centre until September 2023 due to the extenuating circumstances of the effects of the pandemic on the Centre's activities. In 2021: Funds delivered to CIPP Rett Centre totaled: £315,836 2. CIPP Rett Database £12,000 is the pro rata sum {2021) for the software li￿nse for the HealthTracker platform. The HealthTracker is an online digital platform, tailored for patients with Rett Syndrome through which families and caregivers can report the patient's symptoms on an ongoing basis. Data are then analysed on an individual level, to check for changes in the presentation of symptoms and to alert local clinical teams and on a group level, to assess patterns in presentation across the disease group or sub-groups, elucidating wider leaming within the field. 3. MECP2 Duplication Syndrome (MDS) research funding via the Rett Syndrome Research Trust (USA) Reverse Rett funds MECP2 Duplication research through our longstanding partnership with the US based, Rett S ndrome Research Trust RSRT In 2021.. Funds delivered to RSRT MECP2 Duplication projects totaled £14,484 4. Contributions to the international research program at the Rett Syndrome Research Trust (USA) Reverse Rett funds laboratory research through our longstanding partnership with the US based RSRT. In 2020, contributions to RSRT We￿ dramatically affected by the pandemic's effect on fundraising. In 2021, with the recommencement of some fundraising activities and adjustment to the changes in fundraising, regular and significant contributions have resumed. In 2021: Funds delivered to the RSRT international research program totaled £IDO,000. These funds supported the work of the Cobb and Bird Labs at the University of Edinburgh.

Reverse Rett Trustee5' annual report For the year ended 31st December 2021 5. Clinical trial expenses £20,390 In 2021, Reverse Rett provided support for the UK clinical trial of Anavex 2-73 in adults. Reverse Rett provided identification, recruitment and retention services to Anavex. The Clinical trial expenses detailed are the costs for patient travel, accommodation, and rneal allowances for study visits. These funds were provided to the charity in advance of the study visits and deployed and accounted for accordingly with reports sent back to the sponsors on a quarterly ba515. 6. Rett Disorders Alliance £0 Reverse Rett holds the fund for the Rett Disorders Alliance. In 2018, a grant of £5000 was received from the Bolland Charitable Trust by Reverse Rett and designated to the Rett Disorders Alliance fund. These funds were used for the production and printing of the Health Checklist so that it could be distributed to families and dinicians across the UK as needed. In 2021: No RDA funds were spent in 2021 and the fund balance is £4,861. 7. Parent 2 Parent program £17.529 Reverse Rett is a patient advocacy and research organisation and doe5 not formally provide support services to families of patients with Rett Syndrome. The Pa￿nt 2 Parent Project was founded in 2012 with support from Roald Dahls Marvelous Children's Charity, to facilitate connections between parent mentors and newly diagnosed familieslthose in need of additional support. Over time and with the influence of the pandemic and the effect of lockdowns on our community, with support from Contartffhe Pears Foundation. this program evolved to become Rett Connett. Rett Connect encompasses three projects; Parent 2 Parent, Reverse Rett Bitesize and Reverse Rett Family Forum. £17,529 from ContacVThe Pears Foundation supported this work. 8. Rett Registry UK £12.400 In 2021, Reverse Rett started a projert to enhance and develop the Rett Registry UK. Rett Registry UK is the most comprehensive registry of children, young people and adults with Rett Syndrome in the UK, but until last year, it was simply a locked spreadsheet which had no real direct benefit for families. The overall purpose of the Registry is to provide the organisation with the logistical information, demographics and necessary consents to contatt families re research opportunities and to recruit patients for clinical trials. The re-development of the Registry into an independently hosted website application has provided parents and carers with a comprehensive suite of features to help reduce admin, link to useful resources, and connett up to the wider community. The app also gives families and carers direct control over their own data and the ability to continuously update the app, downloadldelete their own dats. It has enabled the organisation to more effectively champion the need for new and emerging treatments to be implemented in the UK and given us the tools we need to efficiently manage clinical tmal recruitment and retention services. The Rett Registry UK was built by the Mather Group 10 and can be found here httr www.rettre 1st with kind sUPPOrt from GW Pharmaceuticals (£10,000).

Reverse Rett Trustees. annual report For the year ended 31st December 2021 9. Governance costs £5520 All charities registered in England and Wales with an income over £500,000 are mandated to have an annual independent audit. These govemance costs ￿present the cost of our 2021 audit and related accountancy services. io. Support costs (note 71 p 23) £291.841 In 2021, support costs included the above govemance costs. office rental, general office costs including phone, internet, printing and postage and staff costs of £219, 149. staff costs listed here are for CEO <￿), Clinical Trial Lead and Supporter Care, (0.5 FTE), Finance Officer, Office Administrator/Clinical Trial Co-ordinator, Design and Marketing Lead and Special events fundraiser. Staff costs under fundraising costs include.. Clinical Trial Lead and Supporter Care (0.5 ￿E), Events and Outreach Lead (Ft) Special events fundraiser (0.4 FtE) Achievements and performance The charity's main activities and who it tries to help are described below. All its charitable activities focus on delivering treatments and a cure for Rett Syndrome and are undertaken to further Reverse Rett's charitable purposes for the public benefit. The main achievements of the charity Reverse Rett has been at the forefront of UK Rett Syndrome laboratory and clinical research funding for more than a decade. The timeline below shows key milestones demonstrating progress in the field since the reversal experiments of 2007 and the work of Reverse Rett which was launched in 2010. Over the last ten years, Reverse Rett has been tightly focused on research funding. Change is now within reach. Three human gene therapy clinical trials are firmly on the horizon and as an organisation, we need to do more. Our first principle is equality- that all patients with Rett Syndrome regardless of age or gender, should have access to emerging treatments and cures. As well as continuing to fund clinical and laboratory research, we continue to seek out and register as many UK patients as possible, wherever they are, so that we can reach them when treatments which will improve their lives become viable. We are doing this in a few ways, through increased provision of health information, through the Rett Connett program and more. We continue to work in support of UK clinical trials of emerging treatments. Reverse Rett provides core funding to the CIPP Rett Centre, which manages the health the most complex Rett patients in the country, extrapolating and disseminating learnings which can improve the health and quality of life of Rett patients of all ages, internationally. We are proud of our past achievements and positive about the future unfolding before us. Below, you can see a timeline of key milestones that show progress in the field since the reversal experiments of 2007 and in the work of Reverse Rett which was launched in 2010.

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Organisational Achievements 2010 / Reverse Rett is founded by five parents from the home of now CEO, Rachael Stevenson. 2011 O Launch of RSRT'S international MECP2 Consortium to combine global efforts to find a tangible way to reverse Rett in humans. O Winners of Best New Charity at the Just Giving Award 2012 / Reverse Rett passes first million-dollar mark, delivering over $lm to Rett Syndmme research mid-year. O Winners of Best New Charity at the Just Giving Award 2013 O Gene therapy work part funded by Reverse Rett demonstrates reversibility of symptoms of Rett Syndrome in mice. / The Rett Syndrome Research Trust (RSRT) launch international Gene Therapy Consortium to compound efforts to drive Gene Therapy for Rett into human trials. O Reverse Rett initiates a UK Patient Registry for UK patients with Rett Syndrome to ensure readiness for UK clinical trials. O Reverse Rett Co-Founder and CEO joins the Board of Trustees of the Rett Syndrome Research Trust 2014 / Reverse Rett begin seed-funding King's College London Research Team at CIPPRD, for work focused on developing new outcome measures (TRIAL Database) for patients with Rett Syndrome under Professor Paramala Santosh. 2015 / The first family focu5 groups are held to inform KCL work on the TRIALdatabase. O Reverse Rett international ￿searCh funding to RSRT passes $5 million-dollarmark

Reverse Rett Trustees. annual report For the year ended 31st December 2021 2016 / Reverse Rett facilitates the implementation of the first UK clinica I trial for an emerging treatment (Sarizotan) for Rett Syndrome, committing funding for a Clinical Trials Coordinator based at King's College London. O Reverse Rett CEO gives evidence at Ethics Committee hearing for Sarizotan clinical trial. 2017 / The Sarizotan clinical trial is launched in QI under the leadership of Dr Paramala Santosh at King's College Hospital. London. Reverse Rett providing identification, pre-screenlng, referral and retention servlces. O RSRT/AveXis announcement of development of first human clinical trial for gene therdpy in patients with Rett Syndrome. 2018 O Reverse Rett granted full membership of the UK'S Association of Medical Research Charities (AMRC). 2nd UK clinical trial for a potential treatment (cannabidiol) launched at three UK trial sites. Reverse Rett providing identification, pre-screening, referral and retention services. 2019 / Reverse Rett CEO gives evidence at London Ethics Committee hearing for 3rd UK clinical trial for an emerging treatment for Rett Syndrome. / Reverse Rett commits to funding the CIPP Rett Centre for three years. The CIPP Rett Centre is the UK'S first dedicated clinical treatment and research centre for children and adults with Rett Syndrome and related disorders and is based in London. The CIPP Rett Centre launched in Sept 2019. 2020 0 3rd UK clinical trial for a potential treatment (Anavex 2-73) launched at KCL with two other UK trial sites to follow. Reverse Rett providing identification, referral, and retention services. 0 2021 Three gene therapy companies announce their intention to file IND applications for upcoming clinical trials of gene therapy in Rett Syndrome before the end of 2021. 2021 / Reverse Rett supports the implementation Of 31d UK clinical trial (Anavex 2-73 adults) at two trial sites

Reverse Rett Trustee5' annual report For the year ended 31st December 2021 2022 / Reverse Rett supports the implementation of 4th UK clinical trial (Anavex 2-73 paediatric) at up to six trial sites. O Taysha Gene Therapies files INDICTA with Health Canada and receives green light for the first in human gene therapy trial for Rett to start this year.

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Beneficiaries of our services The beneficiaries of our services are children and adults with Rett Syndrome and related disorders. Improvements in the symptoms of Rett Syndrome can have far-reaching effects, beyond the individual patient. There are over 50 reported symptoms of Rett Syndrome; in particular, autonomic disturbances cause significant disruption in the lives of patients and the families who care for them. Amelioration of symptoms such as sleep difficulties. agitation. breathing problems and anxiety can have a significant impact on the lives of patients and families, increasing stress and isolation and impatting the health and well-being of other family members as well as the patient. At Reverse Rett, we work to enable patients to access emerging treatments through clinical trials as soon as these treatments become available. Reverse Rett has also been instrumental in facilitating the delivery of UK clinical trials through our work in irnproving UK clinical provision for patients with Rett, the re-development of the Rett Registry UK, our recruitment, pre-screening and retention support for clinical trials and our long-tem) commitment to fund the CIPP Rett Centre (formerly CPMRS). The CIPP Rett Database which monitors the condition of patients with Rett Syndrorne of all ages and stages, all around the UK, gathering anonymized data about disease progression and burden on patients and families which will be an integral component of driving emerging treatments through the regulatory processes. Both the patient-centred and digital aspects of the work of the CIPP Rett Centre simultaneously generate learning about disease progression and management that is helping patients today, before treatments and a cure become available. Ultimately, a treatment focused on repairing the underlying cause of the disorder {a lack of mecp2 protein) is needed to significantly reduce or reverse several existing symptoms. Gene therapy programs which are now being championed by industry are happening as a direct result of laboratory research which Reverse Rett has heavily financially supported over the last decade via the RSRT MECP2 Consortium and RSRT Gene Therapy Consortium. We hope that this year, we will begin to better understand the effects of gene therapy in people with Rett Syndrome, as the first patients have the tremendous opportunity to trial these products. It may be that those who are able to access cures eadier in life recover most effectively. At Reverse Rett, as well as working to bring treatments for Rett Syndrome to fruition. we are also focused on making sure that emerging treatments are available to patients with Rett Syndrome of all ages, stages and genders. We believe that no one should left behind. when treatments that can drastically improve lives become our reality. io

Reverse Rett Trustees, annual report For the year ended 31st December 2021 The Board of Trustee5 of Reverse Rett would like to thank the following companies, community groups, trusts and individuals who generously supported our work in 2021: Amanda Adams Jim Amos Archerfield Estate Derek and Jenny Bird S J Bradbury Neil and Kate Buckley Kerry Burroughs Christopher Cant Caterpillar Cares Society Charities Trust Elisabeth Christopher Cleeve Vale Rotary Club Jorge Conde Core Marketing Cure for Dylan Keki Dadiseth Martin Darby Mary Davidson Elly Douglas-Hamilton DT Impact and Influence Flowers by Enchantment C/0 Neil Buckley David Ford Sean Forde Ray Holden Friends of Holly Colin Gordon Greenergy HG Capital Hllnspire Tim Jones KDW Financial Planning Barnaby Lashbrooke David Lashbrooke Danielle Ledger Chris Lowe Masonic Charitable Foundation Masons Internet Lodge 9659 Mersey Valley Golf Country club Committee Masonic Charitable Foundation Patricia Mccall Scott and Kate Mcmaster Muchloved Murphy-Neumann Charity Company Limited Nicky McBurney Charity Bootcamp Kate Noble Northern Ireland Elertricity service charities committee Peter O'Grady Peter Meyer Trust Kelly Phillips Gillian Prett Mark Ross Rita and Gavin Ross Savills John and Maureen Sharpe Clive Sheridan Matt Smith Anthony and Joanna Snyder David H Starbuck St Michael & All Angels Church Charlie Talbot Thrill Collins Thomas Mcmaster and Son LTD Gillian Tree Myfanwy Tree McKay Williamson Alvin and Stephanie Wood Stephanie Zinser From Grants and trusts The Pears Foundation Mrs F B Laurance Charitable Trust The Munro Foundation The Patrick & Helena Frost Foundation The Sumray Trust The Sylvia Aitken Charitable Trust li

Reverse Rett Trustees. annual report For the year ended 31st December 2021 The Board of Trustees would like to take this opportunity to acknowledge the significant contribution of individuals, Companies and community groups who have raised funds for Reverse Rett via online giving facilities such as Just Givingi the Big Give Christmas Challenge and Facebook birthdays as well as other online fundraising challenges and campaigns. We couldn't do what we do without you. Financial review 2020 was a difficult year for Reverse Rett. Income dropped by 270/0 compared to 2019 due to the Pandemic and sharp decrease in fundraising events and artivities. In 2021, despite a lengthy third lockdown and community fundraising not resuming in earnest until June/July, the year ended strongly with a IOO/o improvement on 2020 and a return to almost pre-pandemic levels. Projections for 2022 remained conservative and on track to meet year end estimate of £689,000. Here are some of the income movements for our three largest income streams: In 2021, the Reverse Rett Winter Gala was a virtual event as well as an in-person event to cover all eventualities with the pandemic. The event income surpassed pre-pandemic levels. (2019: £138,758, 2020: £91,317, 2021.. £153,718. The Big Give Christmas Challenge is always a virtual event. This year income from this event increased by 260/0 on 2020. {2019'. £74,238, 2020.. £82,502, 2021: £110,788) Just Giving income has increased by a modest 4Vo on 2021 (2019- £212,831.89, 2020: £163,395, 2021.. £169,830.43). This shows a slight recovery from the pandemic but acknowledging that online fundraising has been through some lasting changes in the last few years which will no doubt continue to evolve, as other more immediately accessible platforms such as Facebook online giving. There are no uncertainties about the charity's ability to continue as a going concern. 12

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Reserves policy Reverse Rett 15 a parent-driven, patient organisation. Children and adults with Rett Syndrome are atthe heartof everything we do. The relentless nature of the condition demands that they should be able to access treatments and cures as quickly as possible. Funds raised and donated are typically deployed to research projects on a quarterly basis. In 2020, the charity held a greater sum in reserve because of the ongoing unpredictability of the fundraising situation during the pandemic and the cornmitment of £998,000 over three years made to CIPP Rett Centre in September 2019. The charity holds a minimum of 6 months running costs as free reserve.Tot31 fund5 held at year end wa5 £293,905 of which £77,179 was restricted. Plans for the future In early 2021, the Reverse Rett Board of Trustees set to work to develop a new long-term strategy for the organisation. The strategy document is entitled 'Change is within Reach,, the Reverse Rett Strategy 2021-2026. This longer-term plan feeds into the current dynamic annual plan and provides helpful longer-term perspective. In 2021, Reverse Rett is focused on- Research: Continuing to financially 5UPPOrt and monitor the CIPP Rett Centre and CIPP Rett Database. Building international research contributions to RSRT to pre-pandemic levels. Providing recruitment and retention services for on-going and new clinical trials. Developing relationships with industry partners re emerging products. Advocacy: Undergoing audit of HTA preparations and access planning. Outreach: Increasing general public awareness and knowledge of Rett Syndrome and MECP2 Duplication Syndrome so that we are able to register and contact affected patients who many benefit from emerging treatments. Directly seeking out under-represented groups and unidentified children and adults with Rett Syndrome for the same reason. Clinical care: Improving clinical care and outcomes for complex UK children and adults with Rett Syndrome whilst disseminating research and clinical best prdctice information to improve rnedical management of everyone affected. Structurei governance and management Reverse Rett is a company limited by guarantee, company number 07278507 incorporated on 9th 13

Reverse Rett Trustees. annual report For the year ended 31st December 2021 June 2010. The company was established under a Memorandum of Association which established the objects and powers of the charitable company and is govemed under its articles of association. Reverse Rett is a charity registered in England and Wales, charity number 1136809 and a charity registered in Scotland, charity number SC046735. 14

Reverse Rett Trustees. annual report For the year ended 31st December 2021 The first Trustees are those persons notified to Companies House as the first Directors of the Charity. The Charity may by ordinary resolution, appoint a person who is willing to act as a Director and determine the length of rotation in which any additional directors are to retire. Rachael Stevenson and Andrew Stevenson were involved in the founding of the Charity and remain Trustees to date. The management of the company is the responsibility of the Trustees who are elected and co- opted under the temis of the Articles of Assoclation. The trustees are members of the charity, but this entitles them only to voting rights. The trustees have no beneficial interest in the charity. Members of the charity guarantee to contribute an amount not exceeding £1 to the assets of the charity in the event of winding up. The total number of such guarantees on 31 December 2021 was ii. The Trustees of the Charity who served during the year ended December 31st 2021 are shown on pl. The Trustees generally meet in person, once annually and via online conferencing on a bi- monthly basis and as needed basis. Since the pandemic started, Trustees have met more frequently and through online face to face meetings via Zooml As a parent-driven, patient organisation, Reverse Rett looks first to the Rett Syndrome community to recruit Trustees. The organisation's founding document states in section 19 that A Director must be a natural person aged 16 years orolder. No one may be appointed a Director if he or she would be disqualified from acting under the provisions of article 21. Potential trustees are nominated to the Board by one or more of the existing Board members. The validity of the nomination is discussed. The Trustees then vote on whether to approve the membership of the proposed individual. No other person or external body is pemiitted to appoint charity trustees. Induction and training of Trustees is delivered in person through one-to-one contart with the organisation's Chairman, where Trustee's roles and responsibilities a￿ explained and supporting information is sent to the newly recruited Trustee as appropriate. 15

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Reverse Rett is a full member of the umbrella organisation, the Association of Medical Research Charities (AMRC). Membership of AMRC requires member organisations to fulfil specific criteria with regards to a high standard of external peer review of proposed research projects and subsequent monitoring. Detailed information about the established AMRC peer review process at Reverse Rett can be found here. htt www.reverserett.or what-we-do how-we-fund-uk-clinical-research The Board of Trustees of Reverse Rett delegates day to day operational responsibility of the Drganisation to the CEO, Rachael Stevenson. In accordance with the charity's Financial Procedures Policy, expenditure of >£20K must be approved by Board Chairrnan as well as CEO. The Board of Trustees must review and approve: New organisation policies Amendments to existing policies Funding of new research projects Salary increases for CEO and FM The Reverse Rett Conflirt of Interest Policy is signed annually by all Trustees. Remuneration policy for key management personnel Two of the charity's Trustees are full-time employees of the organisation and thus receive a salary for their work. As Founding Trustees of the organisation, Rachael Stevenson and Andrew Stevenson are recused from any Board meetings to discuss the details of their employment at Reverse Rett. Adjustments in remuneration for both parties are decided by the Board of Trustees. Employment of Directors of the Charity is permitted by Article 6.4.2 of the Memorandum and Articles of Association of the Charity which provides that Directors of the Charity may be employed providing that the majority of Directors do not benefit in this way. All remaining trustees give their time voluntarily and receive no benefits from the charity. Any expenses reclaimed from the charity by these Trustees are set out in note 10 to the accounts. 16

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Related parties and relationships with other oryanisations Reverse Rett is a full member of the Association of Medical Research Charities (AMRC) We work in partnership with the following organisations: Rett Syndrome Research Trust (USA) -providing fijnding for UK based RSRT research projects Rett Disorders Alliance UK -working on areas of common interest to benefit the UK Rett community Rett UK -UK patient organisation focused on family support for those affected by Rett Syndrome Opé Rett Gudrun's Rett Syndrome Research Trust Israel Rett Syndrome Research and Treatment Foundation The followlng are Internatlonal oryanlsatlons from whom we have recelved donatlons durlng the 2021 financial year: Opé Rett With special thanks to our industry partners: GW Pharmaceuticals Anavex Life Sciences Corp. Taysha Gene Therapies Neurogene Inc. Risk management During the annual in person board meeting 2021, the charity trustees considered the major risks to which the charity is exposed. These include but are not limited to: Sudden major decrease in fundraising Key personnel changes Keeping a six-month reserve protects the charity in the short term from a major decrease in fundraising which we have now experienced due to the Covid-19 outbreak. The potential for key personnel changes will be reviewed on an ongoing basis. The charity is insured against the loss of the Executive Director as recruitment for this post is likely to bring a significantly increased cost for the charity. In 2022, Reverse Rett is working to broaden the management base to deliver more pmtertion for the charity against the loss of key personnel. 17

Reverse Rett Trustees. annual report For the year ended 31st December 2021 Fundraising Reverse Rett is registered with the Fundraising Regulator and considered to be demonstrating commitment to good fundraising practice. Reverse Rett is committed to following the Fundraising Regulator's Code of Fundraising Practice and the Fundraising Promise and is permitted to use the Fundraising Regulator badge on all fundraising materials. There has been no failure to comply with the scheme or the standards ￿ferred to in (l) above. Reverse Rett's approach to fundraising is laid out in our Fundraising Principles and Fundraising Policies for community fundraising and events which are sent out to all new fundraisers. The charity monitors activities carried out on behalf of the charity for the purpose off fundraising through on-going interpersonal relationships with fundraisers and supporters of whom we are aware. The number of complaints received by the charity or a person acting on its behalf about activities by the charity or by a person on behalf of the charity for the purpose of fundraising during 2021 was O. In 2021, the charity has updated the Rett Registry UK complete with a suite of privacy and data protection tools to ensure that the privacy of all registrants and their families is secure. All fundr8iser/supporter personal information is held on a secure third party platform called Donorfy. Consents to hold lirnited information are secure. Reverse Rett does not engage in telephone, mail or on the street cold solicitations and these actions by another person on behalf of the charity are not permitted. The charity has not acted as custodian trustee dLJring the reporting period. 18

ststement of responslbllltles of the trustees The trustees {who are also direciors of Frs102 company charity for the purposes of company law) are responsible for preparing the trustees. annual report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice). Company law requires the trustees to prepare financial statements for each financial year which give a true and fair view of the state of affairs of the charitable company and of the incoming resources and application of resources, including the income and expenditu￿, of the charitable company for that period. In preparing these financial statements. the trustees are required to: Selert suitable accounting policies and then apply them consistently Observe the methods and principles in the Charities SORP Make judgements and estimates that are reasonable and prudent State whether applicable UK Accounting Standards and statements of recommended prattice have been followed, subject to any material departures disclosed and explained in the financial statements Prepare the financial statements on the going concern basis unless it Is Inappropriate to presume that the charity will continue in operation The trustees are responsible for keeping proper accounting records that disclose with reasonable accuracy at any time the financial position of the charitable company ar)d enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the charitable company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities. In so far as the trustees are aware: There is no relevant audit information of which the charitable company's auditors are unaware The trustees have taken all steps that they ought to have taken to make themselves aware of any relevant audit information and to establish that the auditors are aware of that information The trustees are responsible for the maintenance and integrity of the corporate and financial information included on the charitable company's website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdirtions. The trustees, annual report has been appmved by the trustees on 3110812022 and signed on their behalf by John Sharpe Chairman 19

Independent Auditors’ Report to the Members and Trustees of Reverse Rett

Opinion

We have audited the financial statements of Reverse Rett (the ‘charitable company’) for the year ended 31 December 2021, which comprise the Statement of Financial Activities (including the income and expenditure account), the Balance Sheet, the Statement of Cash Flows and the related notes. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including Financial Reporting Standard 102 The Financial Reporting Standard applicable in the UK and Republic of Ireland (United Kingdom Generally Accepted Accounting Practice). In our opinion the financial statements:

Basis for opinion

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the Auditor’s responsibilities for the audit of the financial statements section of our report. We are independent of the charitable company in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the FRC’s Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Conclusions relating to going concern

In auditing the financial statements, we have concluded that the trustees’ use of the going concern basis of accounting in the preparation of the financial statements is appropriate.

Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the charitable company's ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.

Our responsibilities and the responsibilities of the trustees with respect to going concern are described in the relevant sections of this report.

Other information

The trustees are responsible for the other information. The other information comprises the information included in the trustees’ annual report, other than the financial statements and our auditor’s report thereon. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon.

In connection with our audit of the financial statements, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether there is a material misstatement in the financial statements or a material misstatement of the

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Independent Auditors’ Report to the Members and Trustees of Reverse Rett

other information. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We have nothing to report in this regard.

Opinions on other matters prescribed by the Companies Act 2006

In our opinion, based on the work undertaken in the course of the audit:

Matters on which we are required to report by exception

In the light of our knowledge and understanding of the charitable company and its environment obtained in the course of the audit, we have not identified material misstatements in the trustees’ report. We have nothing to report in respect of the following matters in relation to which the Companies Act 2006 requires us to report to you if, in our opinion:

Responsibilities of trustees

As explained more fully in the trustees’ responsibilities statement set out on page 18, the trustees (who are also the directors of the charitable company for the purposes of company law) are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as the trustees determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, the trustees are responsible for assessing the charitable company’s ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the trustees either intend to liquidate the charitable company or to cease operations, or have no realistic alternative but to do so.

Auditor’s responsibilities for the audit of the financial statements

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.

21

Independent Auditors’ Report to the Members and Trustees of Reverse Rett

Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The specific procedures for this engagement and the extent to which these are capable of detecting irregularities, including fraud is detailed below:

Because of the inherent limitations of an audit, there is a risk that we will not detect all irregularities, including those leading to a material misstatement in the financial statements or non-compliance with regulation. This risk increases the more that compliance with a law or regulation is removed from the events and transactions reflected in the financial statements, as we will be less likely to become aware of instances of non-compliance. The risk is also greater regarding irregularities occurring due to fraud rather than error, as fraud involves intentional concealment, forgery, collusion, omission or misrepresentation.

A further description of our responsibilities is available on the Financial Reporting Council’s website at: https://www.frc.org.uk/Our-Work/Audit/Audit-and-assurance/Standards-and-guidance/Standards-andguidance-for-auditors/Auditors-responsibilities-for-audit/Description-of-auditors-responsibilities-foraudit.aspx. This description forms part of our auditor’s report.

Use of our report

This report is made solely to the charitable company’s members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the charitable company’s members those matters we are required to state to them in an auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the charitable company and the charitable company’s members as a body, for our audit work, for this report, or for the opinions we have formed.

Chinwe Jennifer Daniel FCCA DChA

Senior Statutory Auditor

for and on behalf of

Slade & Cooper Limited Statutory Auditors Beehive Mill Jersey Street Manchester, M4 6JG Date: ______

22

Reverse Rett

Statement of Financial Activities

(including Income and Expenditure account) for the year ended 31 December 2021

Unrestricted
funds
Note
£
Income from:
Donations and legacies
3
345,684
Charitable activities:
4
326,458
Total income
672,142
Expenditure on:
Raising funds
5
155,571
Charitable activities:
6
645,369
Total expenditure
800,940
8(128,798)
Transfer between funds
-
Net movement in funds for the year
(128,798)
Reconciliation of funds
Total funds brought forward
345,524
Total funds carried forward
216,726
Net income/(expenditure) for the
year		 Restricted
funds
£
8,000
36,152
44,152
-
52,403
52,403
(8,251)
-
(8,251)
85,430
77,179		 Total funds
2021
£
353,684
362,610
716,294
155,571
697,772
853,343
(137,049)
-
(137,049)
430,954
293,905		 Total funds
2020
£
357,458
293,966
651,424
110,401
569,000
679,401
(27,977)
-
(27,977)
458,931
430,954

The statement of financial activities includes all gains and losses recognised in the year. All income and expenditure derive from continuing activities.

23

Reverse Rett Company number 07278507

Balance sheet as at 31 December 2021

Note
£
£
Fixed assets
Tangible assets
12
2,155
Total fixed assets
2,155
Current assets
Debtors
13
50,803
Cash at bank and in hand
345,924
Total current assets
396,727
Liabilities
Creditors: amounts falling
due in less than one year
14
(104,977)
Net assets
293,905
The funds of the charity:
Restricted income funds
15
77,179
Unrestricted income funds
16
216,726
Total charity funds
293,905
2021		 £
£
3,504
3,504
109,163
409,978
519,141
(91,691)
430,954
85,430
345,524
430,954
2020		 £
£
3,504
3,504
109,163
409,978
519,141
(91,691)
430,954
85,430
345,524
430,954
2020
3,504
430,954
85,430
345,524
430,954

These accounts are prepared in accordance with the special provisions of part 15 of the Companies Act 2006 relating to small companies and constitute the annual accounts required by the Companies Act 2006 and are for circulation to members of the company.

The notes on pages 26 to 39 form part of these accounts.

Approved by the trustees on 31/08/2022 and signed on their behalf by:

Helen Simmonds (Vice-Chair)

24

Reverse Rett

Statement of Cash Flows for the year ending 31 December 2021

Note
2021
£
Cash provided by/(used in) operating activities
19
(64,054)
(64,054)
Cash and cash equivalents at the beginning of the year
409,978
Cash and cash equivalents at the end of the year
345,924
Increase/(decrease) in cash and cash
equivalents in the year		 2020
£
47,353
44,455
365,123
409,578

25

Reverse Rett

Notes to the accounts for the year ended 31 December 2021

1 Accounting policies

The principal accounting policies adopted, judgments and key sources of estimation uncertainty in the preparation of the financial statements are as follows:

a Basis of preparation

The financial statements have been prepared in accordance with Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102), second edition - October 2019 (Charities SORP (FRS 102)), the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) and the Companies Act 2006 and UK Generally Accepted Accounting Practice.

Reverse Rett meets the definition of a public benefit entity under FRS102. Assets and liabilities are initially recognised at historical cost or transaction value unless otherwise stated in the relevant accounting policy note.

Reconciliation with previous Generally Accepted Accounting Practice

In preparing the accounts, the trustees have considered whether in applying the accounting policies required by FRS 102 and the Charities SORP FRS 102 the restatement of comparative items was required. No Restatements were required.

b Preparation of the accounts on a going concern basis

The trustees consider that there are no material uncertainties about the charitable company's ability to continue as a going concern.

The trustees have made no key judgments which have a significant effect on the accounts.

The trustees do not consider that there are any sources of estimation uncertainty at the reporting date that have a significant risk of causing a material adjustment to the carrying amount of assets and liabilities within the next reporting period.

26

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

c Income

Income is recognised when the charity has entitlement to the funds, any performance conditions attached to the item(s) of income have been met, it is probable that the income will be received and the amount can be measured reliably.

Income from government and other grants, whether ‘capital’ grants or ‘revenue’ grants, is recognised when the charity has entitlement to the funds, any performance conditions attached to the grants have been met, it is probable that the income will be received and the amount can be measured reliably and is not deferred.

For legacies, entitlement is taken as the earlier of the date on which either: the charity is aware that probate has been granted, the estate has been finalised and notification has been made by the executor(s) to the charity that a distribution will be made, or when a distribution is received from the estate. Receipt of a legacy, in whole or in part, is only considered probable when the amount can be measured reliably and the charity has been notified of the executor’s intention to make a distribution. Where legacies have been notified to the charity, or the charity is aware of the granting of probate, and the criteria for income recognition have not been met, then the legacy is a treated as a contingent asset and disclosed if material.

Income received in advance of a provision of a specified service is deferred until the criteria for income recognition are met.

d Donated services and facilities

Donated professional services and donated facilities are recognised as income when the charity has control over the item, any conditions associated with the donated item have been met, the receipt of economic benefit from the use by the charity of the item is probable and that economic benefit can be measured reliably. In accordance with the Charities SORP (FRS 102), general volunteer time is not recognised; refer to the trustees’ annual report for more information about their contribution.

On receipt, donated professional services and donated facilities are recognised on the basis of the value of the gift to the charity which is the amount the charity would have been willing to pay to obtain services or facilities of equivalent economic benefit on the open market; a corresponding amount is then recognised in expenditure in the period of receipt.

e Interest receivable

Interest on funds held on deposit is included when receivable and the amount can be measured reliably by the charity; this is normally upon notification of the interest paid or payable by the Bank.

27

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

f Fund accounting

Unrestricted funds are available to spend on activities that further any of the purposes of charity.

Designated funds are unrestricted funds of the charity which the trustees have decided at their discretion to set aside to use for a specific purpose.

Restricted funds are donations which the donor has specified are to be solely used for particular areas of the charity’s work or for specific projects being undertaken by the charity.

g Expenditure and irrecoverable VAT

Expenditure is recognised once there is a legal or constructive obligation to make a payment to a third party, it is probable that settlement will be required and the amount of the obligation can be measured reliably.

Irrecoverable VAT is charged as a cost against the activity for which the expenditure was incurred.

h Allocation of support costs

Support costs are those functions that assist the work of the charity but do not directly undertake charitable activities. Support costs include back office costs, finance, personnel, payroll and governance costs which support the charity's programmes and activities.

i Operating leases

Operating leases are leases in which the title to the assets, and the risks and rewards of ownership, remain with the lessor. Rental charges are charged on a straight line basis over the term of the lease.

j Tangible fixed assets

Individual fixed assets costing £1,000 or more are capitalised at cost and are depreciated over their estimated useful economic lives on a straight line basis as follows:

Office equipment 25% Computer equipment 25%

28

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

k Debtors

Trade and other debtors are recognised at the settlement amount due after any trade discount offered. Prepayments are valued at the amount prepaid net of any trade discounts due.

l Cash at bank and in hand

Cash at bank and cash in hand includes cash and short term highly liquid investments with a short maturity of three months or less from the date of acquisition or opening of the deposit or similar account.

m Creditors and provisions

Creditors and provisions are recognised where the charity has a present obligation resulting from a past event that will probably result in the transfer of funds to a third party and the amount due to settle the obligation can be measured or estimated reliably. Creditors and provisions are normally recognised at their settlement amount after allowing for any trade discounts due.

n Financial instruments

The charity only has financial assets and financial liabilities of a kind that qualify as basic financial instruments. Basic financial instruments are initially recognised at transaction value and subsequently measured at their settlement value with the exception of bank loans which are subsequently measured at amortised cost using the effective interest method.

o Pensions

Employees of the charity are entitled to join a defined contribution ‘money purchase’ scheme. The charity’s contribution is restricted to the contributions disclosed in note 9. There were no outstanding contributions at the year end.

2 Legal status of the charity

The charity is a company limited by guarantee registered in England and Wales and has no share capital. In the event of the charity being wound up, the liability in respect of the guarantee is limited to £1 per member of the charity. The registered office address is disclosed on page 1.

29

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

3 Income from donations and legacies

Unrestricted
Restricted
£
£
Donations
293,495
-
Grants -
Sylvia Aiken Trust
3,000
-
The Patrick and Helena Trust
-
-
Covid Response and JRS
16,189
-
HG Foundation
2,000
-
Childwick Trust
15,000
-
GW Pharmaceuticals
10,000
-
Exceed Trust
1,000
-
The Lawson Trust
5,000
-
Pears Grant
-
8,000
Total
345,684
8,000
Income from donations and legacies - previous year
Unrestricted
Restricted
£
£
Donations
277,897
21,075
Grants
Sylvia Aiken Trust
6,000
-
The Patrick and Helena Trust
10,000
-
Covid Response and JRS
39,311
-
Others
600
2,575
-
-
Total
333,808
23,650		 Total 2021
£
293,495
3,000
-
16,189
2,000
15,000
10,000
1,000
5,000
8,000
353,684
Total 2020
£
298,972
6,000
10,000
39,311
3,175
-
357,458

30

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

4 Income from charitable activities

Unrestricted
£
The Big Give
110,788
London Event
153,718
MECP2 Fund
-
Family events
7,048
Anavex Germany GmbH
22,335
Gift Aid
31,693
Other income
876
Total
326,458
Income from charitable activities - previous year
Unrestricted
£
The Big Give
82,502
London Event
91,317
MECP2 Fund
665
Family events
5,806
Newron Pharmacy
8,874
Parent 2 Parent programme
-
Gift Aid
71,024
Other income
2,512
Total
262,700
5
Cost of raising funds
Staff costs
Fundraiser's fees
Event costs		 Restricted
£
-
-
15,762
-
20,390
-
-
36,152
Restricted
£
-
-
12,960
-
3,633
14,529
-
144
31,266
2021
£
68,177
3,048
84,346
155,571		 Total 2021
£
110,788
153,718
15,762
7,048
42,725
31,693
876
362,610
Total 2019
£
82,502
91,317
13,625
5,806
12,507
14,529
71,024
2,656
293,966
2020
£
63,456
5,139
41,806
110,401

All expenditure on cost of raising funds is unrestricted.

31

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

6 Analysis of expenditure on charitable activities

Staff costs
Travel and accommodation
Clinical trial expense
Parent 2 Parent programme*
CIPP Rett Centre
MECP2
Transfer to Rett Syndrome
Research Trust USA
Governance costs (see note 7)
Support costs (see note 7)		 Unrestricted
£
53,765
100,000
348
-
-
315,836
-
5,520
169,900
645,369		 Restricted
£
-
-
-
20,390
17,529
-
14,484
-
-
52,403		 Total 2021
£
53,765
100,000
348
20,390
17,529
315,836
14,484
5,520
169,900
697,772

Analysis of expenditure on charitable activities - previous year

Staff costs
Travel and accommodation
Kings College Grant
Clinical trial expense
Rett disorders alliance
Parent 2 Parent programme
CIPP Rett Centre
MECP2
Governance costs (see note 7)
Support costs (see note 7)
Transfer to Rett Syndrome
Research Trust USA		 Unrestricted
£
64,253
445
1,688
-
-
-
-
311,137
-
5,640
147,914
531,077		 Restricted
£
-
-
-
-
11,247
-
1,051
-
25,625
-
-
37,923		 2,020
£
64,253
445
1,688
-
11,247
-
1,051
311,137
25,625
5,640
147,914
569,000

32

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

7 Analysis of governance and support costs

Office rental cost
Staff costs
Office costs
Audit fees
Accountancy services
Legal and professional
Advertising and marketing
8
Net income/(expenditure) for the year
This is stated after charging/(crediting):
Depreciation
Operating lease rentals:
Property
Other
Auditor's remuneration - audit fees
Auditor's remuneration - accountancy fees		 Support
£
10,530
97,208
51,506
-
-
9,360
1,296
169,900
2021
£
1,349
-
2,460
3,000
1,600		 Governance
£
-
-
-
3,500
2,020
-
-
5,520
2020
£
1,349
-
2,568
3,000
1,600		 Total 2021
£
10,530
97,208
51,506
3,500
2,020
9,360
1,296
175,420

33

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

9 Staff costs

Staff costs during the year were as follows:

Wages and salaries
Social security costs
Pension costs
Allocated as follows:
Cost of raising funds
Charitable activities
Support costs		 2021
£
206,210
18,525
7,843
232,578
68,177
67,193
97,208
232,578		 2020
£
198,922
18,126
7,356
224,404
63,456
64,253
96,695
224,404

No employees has employee benefits in excess of £60,000 (2020: Nil).

The average number of staff employed during the period was 7 (2020: 7).

The key management personnel of the charity comprise the trustees and the Chief Executive Officer. The total employee benefits of the key management personnel of the charity were £54,453 (2020: £53,040).

10 Trustee remuneration and expenses, and related party transactions

Two of the trustees Rachael Stevenson (Chief Executive) and Andrew Stevenson received remuneration totalling £95,066 during the year (2020:£91,831).

No trustee received travel and subsistence expenses during the year. (2020:nil).

Aggregate donations from related parties were £35,000 (2020: £44,650).

There are no donations from related parties which are outside the normal course of business and no restricted donations from related parties.

The Chief Executive and a director of Reverse Rett, Rachael Stevenson is on the Board of Rett Syndrome Research Trust USA. Monica Coenraads who is also a director of Reverse Rett sits on the Board of Rett Syndrome Research Trust USA.

Reverse Rett made charitable grant to Rett Syndrome USA of £100,000 this year. (2020: £445).

No trustee or other person related to the charity had any personal interest in any contract or transaction entered into by the charity, including guarantees, during the year (2020: nil).

34

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

11 Corporation tax

The charity is exempt from tax on income and gains falling within Chapter 3 of Part 11 of the Corporation Tax Act 2010 or Section 256 of the Taxation of Chargeable Gains Act 1992 to the extent that these are applied to its charitable objects. No tax charges have arisen in the charity.

12 Fixed assets: tangible assets

Cost
Additions
Disposals
Depreciation
Charge for the year
Disposals
Net book value
At
31
December
2020
At 1 January 2021
At
31
December
2021
At 1 January 2021
At
31
December
2021
At
31
December
2021		 Computer
equipment
£
7,525
-
-
7,525
4,021
1,349
-
5,370
2,155
3,504

35

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

13
Debtors
Other debtors
Prepayments and accrued income
Gift aid debtor
Big Give debtor
14
Creditors: amounts falling due within one year
Trade creditors
Other creditors and accruals
Taxation and social security costs		 2021
£
10,837
28,208
1,758
10,000
50,803
2021
£
16,297
74,895
13,785
104,977		 2020
£
6,300
26,672
25,956
50,235
109,163
2020
£
2,351
78,956
10,384
91,691

36

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

15 Analysis of movements in restricted funds

Pears Grant
Total
Total
Rett disorder
alliance
Use in
Parent 2 Parent
Programme
Clinical
Research Funds
Anavex
Germany GmbH
MECP2
Duplication
Previous
reporting period
MECP2
Duplication
Rett disorder
alliance
Use in
Farringdon
Parent 2 Parent
Programme
Clinical
Research Funds		 Balance at 1
January 2021
£
11,090
4,861
200
20,585
48,694
-
-
85,430
Balance at 1
January 2020
£
2,680
4,861
200
7,107
37,589
52,437

 Income
£
15,762
-
-
-
-
20,390
8,000
44,152
Income
£
34,035
-
-
14,529
6,352
54,916		 Expenditure
£
(14,484)
-
-
(17,529)
-
(20,390)
-
(52,403)
Expenditure
£
(25,625)
-
-
(1,051)
(11,247)
(37,923)		 Transfers
£
-
-
-
-
-
-
Transfers
£
-
-
-
-
16,000
16,000		 As at 31
December
2021
£
12,368
4,861
200
3,056
48,694
-
8,000
77,179
31
December
2020
£
11,090
4,861
200
20,585
48,694
85,430

Name of restricted fund Description, nature and purposes of the fund

MECP2

The MECP2 Duplication Fund at Reverse Rett is a restricted fund. The fund exclusively supports projects devoted to the study and means of treatment of MECP2 Duplication/Triplication Syndrome. 100% of funds raised and contributed to Reverse Rett by families of children with MECP2 Duplication Syndrome and their supports in the UK are committed to MECP2 Duplication projects via RSPT US.

37

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

Parent 2 Parent Reverse Rett Parent 2 Parent offers grants parent to parent support as a resource to families of newly diagnosed or struggling children with Rett Syndrome and related MECP2 disorders. Through a one to one 'match', experienced parents provide emotional support to families and assist then in finding information and resources.

The Reverse Rett Parent 2 Parent project is now housed under Rett Connect umbrella. Please see here for more details.

https://www.reverserett.org.uk/rett-connect/

This is a designated fund which will support UK based clinical research and the Clinical Research implementation of treatment for Rett Syndrome and related MECP2 Disorders in Fund the UK.

16 Analysis of movement in unrestricted funds

General fund
Previous
reporting period
General fund		 Balance at 1
January 2021
£
345,524
345,524
Balance at 1
January 2020
£
406,494
406,494		 Income
£
672,142
672,142
Income
£
596,508
596,508		 Expenditure
£
(800,940)
(800,940)
Expenditure
£
(641,478)
(641,478)		 Transfers
£
-
Transfers
£
(16,000)
(16,000)		 As at 31
December
2021
£
216,726
216,726
As at 31
December
2020
£
345,524
345,524

Name of unrestricted Description, nature and purposes of the fund

General fund The free reserves after allowing for all designated funds

38

Reverse Rett

Notes to the accounts for the year ended 31 December 2021 (continued)

17 Analysis of net assets between funds

Tangible fixed assets
Net current assets/(liabilities)
Total		 General
fund
£
2,155
214,571
216,726		 Designated
funds
£
-
-
-		 Restricted
funds
£
-
77,179
77,179		 Total
£
2,155
291,750
293,905

18 Operating lease commitments

The charity's total future minimum lease payments under non-cancellable operating leases is as follows for each of the following periods:

Less than one year
One to five years		 2021
2020
£
£
-
-
-
-
-
-
Property		 2021
2020
£
£
2,460
2,568
4,410
6,870
6,870
9,438
Equipment		 2021
2020
£
£
2,460
2,568
4,410
6,870
6,870
9,438
Equipment
9,438

19 Reconciliation of net movement in funds to net cash flow from operating activities

Net income/(expenditure) for the year
Adjustments for:
Depreciation charge
Decrease/(increase) in debtors
Increase/(decrease) in creditors
Net cash provided by/(used in) operating		 2021
£
(137,049)
1,349
58,360
13,286
(64,054)		 2020
£
(27,977)
1,349
(2,388)
76,369
47,353

39