2021-03-31-accounts

Earlham In8tltut8 | Annual Report and Accounts | March 2021 EARLHAM INSTITUTE Annual Report and Accounts for the year ended 31 March 2021 Registered company nurnber.. 06855533 Registered charity number.. 1136213

Earlham In8tltut8 | Annual Report and Accounts | March 2021 ANNUAL REPORT CONTENTS TRUSTEES, REPORT INCORPORATING THE STRATEGIC REVIEW................................................................ STRATEGIC REVIEW................................................................................................................................... FINANCIAL REVIEW.................................................................................................................................... RISKASSESSMENT AND MANAGEMENT................................................................................................. STRUCTURE, GOVERNANCEAND MANAGEMENT..................................................................... STATEMENT OF TRUSTEES, RESPONSIBILITIES 12 INDEPENDENT AUDITOR'S REPORT FINANCIAL STATEMENTS.................................................................................................................................. 16 REFERENCE AND ADMINISTRATIVE DETAILS................................................................................................. 32 Earlharn Institute is a company limited by guarantee and a registered charity. The Annu81 Report provides information on the legal purpos85 of the Charity, the 3diMties it undert8kgs and its main achievements. The Trustees, Report and Financial Statements have been prepared in accordance with the Accounting and Reporting by Charities.. Statement of Recommended Practice ISORPI, Financial Reporting stand8rd 102 The Financi81 Reporting Stsndard appli¢8ble in the UK and Republic of Ireland IFRS1021, together with th8 reporting reqLJir8m8nts of the Cornp8nies Act 2006 and th8 Chariti85 Act 2011.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 TRUSTEES, REPORT INCORPORATING THE STRATEGIC REVIEW Introduction The past two decades have laid the foundations for 8 new era of genome-based understanding of genetic5 and the biology of complex systems. Technological adVan￿S in DNA sequencing have resulted in multiple slepss the life sciences, from plants to animals to microbes. In parallel the emergence ol the data Scien￿$, artificial intelligence and the need for data sharing, has opened new opportLJnities. E8rlh8m Institute IEII is founded on these two revolutions and h85 beoome a leading interdisoiplin8ry institute in the UK, combining genomics and big data. El'5 Mission El's tllission is to advanc8 and enabl8 biosci8nc8 by applwng (xjmputational and data driven approaches. El's strategy has relied on the implementation of novel applications, establishing collaborative work to advan knowledge in biosaenTrs, develop novel applications in biolechnolooy, and promole the growth of the UK bioeconomy. The Institute's current mission is built on strong foundations and rests on three key strengths.. Expertise- El hosts one ol the largest and most experienced teams in the UK specialising in the generation and analysis of genomic dat8 using n8Xt%eneration sequencing Technology - El's genomic and computing platforms include the most advanced equipment and are configured specifically to deliver cornpetib.ve analysis for large or complex genornics datasets Digital Infrastructure El is at the forefront in the development of specialised databases. pipelines and software for data analysis and visualisation. El's Strategy El's Scien￿ strategy °Decoding Living Systems" brings together a wealth of exper￿Se in bioscien￿$, bioinformatics, high performance wmputing and st8tisti¢s to understsnd wmplex biological systems in plants 3nd animals and their interaction with the environment. El's advanced genomics and compuiats.onal plafforms support data-intensive research that embraces and confronts modern scientific challenges arising from data scale and complexity. We develop and implement new technologies and apply computational rn8thods to process, Store and interpret cornpl8x and diver58 d8ta58ts, to 8nabl8 bioscience research. The science faculty collectively conducts three principal kinds ol research activities.. Fundamental research to increase the knowledge base in bioscience. Applied research to improve plant, animal and human health. Enabling research to empower both academia and indLJStry with new technologies and scalable bioinfomatics approaches. Th8 focus will b8 on int8rpr8ting cornp18X Tnolecular and c811ular data using advanced COrnPLrt8tional and Al approaches. This will impact on all areas of bi(>logical science and wll continue to demand skilled personnel, computational systems and analytical tools. El is moving rapidly from an erd where the emphasis was on generating data. to one in which genome-wide sequencing and other'omic5 technologies can be used routinely for multiple assays but are often complex to analyse requiring nov818nd adapt8bl8 approaches. Culture El's success is founded on a culture defined by the following core values.. Openn8ss- WE promote the dissemination of kno￿edge and di5tribLJtion of d8ta and software ttx)Is by following open and transparent data-sharing policies that are embedded in El's research programmes. Technical Excellence- We are committed to eontinuous improvement, and to work to the highest standards of quality across the organisation. Developing and Rewarding T8lent- We airn to recruit, train and retain highly skilled and talented people Innovation- We apply novel, state ol the art technologies to deliver innovative approaches. Collaboration- We work collaboratively. internally and externally. through mutual respect and openness. Equality & Diversity-we value, encourage and support the diversity ol all who work in our institute.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 Public Benefit El advances biological and biotechnological science for the public benefit by undertaking and promoting research relating to genomes and their functions, in particular this year by carrying out the following activities.. Applying our science to issues of public interest e.g. Understanding the diversity of Bees and Pollination and miorobiomes. Being part of the n8tion818fft>rts to respond to the Covid-19 pandemic. Working with industrial partners and breeders to apply our knowledge and expertise to develop robust crops and fo(Kl sources for the future. whilst understanding natural diversity. Working with low income countries to build ￿Search capacity that will enable them to developtheir knowledge. Training of scientists and 8ncouraging thern to participat8 in public 8ngag8m8nt. Contributing to the local, nation81 and intemational economy by training first rate scientists Coronavirus Pandemic The coronavirus ICovid191 pandemic has brought many challenges to the world. Working Closely with our Norwich Research Park partners we were able to redirect some of our expertise to support the local hospital to automate Covid-19 testing and make a difference to our region. The Institute was also able to support its staff and students, and minirnise disruption to our science programmes. We also had a key focus on supports'ng our staffs wellbeing. For mor8 inforrnation s88 our p8rform8nce report. Our Performance Our performance against the 2020121 objectives is highlighted in the table beltsw.. Objectives Our Perfom)an¢e Continue the growth and During the last financial year scientists at El published 112 publications and shared development of our 14 research tool, m8thod5, datab8s85 and mod81s with the wider 5a8ntific world leadlng research community. Our scientists also delivered 24 oral and 14 poster presentations at programme$, increase national and international conferen￿5 which were held in a virtual forrnat during the our published outputs past year. The diversity ol our funding portfolio has expanded with funding reeeived and diversify our grant from the Wellcome Trust, MRC and NERC in addition tr) BBSRC. income. Build more industrial collaborations so that we are aligned to government strategy and can achièva Impact from our research With managed 21 projects with 16 industrial partners funded by.. UKRI IBBSRC, EPSRC, Innovate UK, MRCI, Royal Acadetmy of Engineering, and industry. Our collaborations span plant breeding and agrochemical sector, biotech industry, specialist sequencing and instrumentation companies, dats management and bioinformatics cornpanies, and d8f8nc& and security s8Ctor. We h8V& 8 strong pipeline of ICASE studentships arising from these collaborations. We have maintained the existing and developed new relationships with industry through mechanisms such a5 external engagement events, industry seminar progratntne and joint Pho studentships. Our industry facing event El Innovate 2020 attracted 170 attendees, arnong 115 external participants from 73 diffe￿nt organisations, and generated 26 new connections with industry and 8cad8tMia. Projects to translate our research 8nd help lo realise societal, economic 8nd environmental impact, nationally and intemationally included." a modular synthetic biology pipeline for the engineering bioactive dyes which can help lo reduce environm8nt81 irnp8Ct of th& t8Xti18 dy8ing industry 8nd,' investigating a new drug target lor treatment of schizophrenia with the intemational Psychiatry Consortium, a £4 million collaboration between seven global pharmaceutical companies and two leading research ¢h8ritigS. Work Continues on the ooll8boration wth WorldFish which aims to aC￿lerate selective breeding of tilapia in the Lake Victoria Basin catchment working with institutions based in Kenya. Tanzania and Uganda. The newly awarded UKRI GCRF GastroPak project started in 2020 with El working with institut8s in Pakistan INational University of Sciences & Technology in Islamabad and the University of Agriculture Faisalabadl. the National University of Galway and other UK insty'tutes. This a multidis¢iplin8ry project to quantify the transrnission routes of gastroenteritis in Pakistan and develop targeted interventions. Strengthen our partnèrships through collaboration with world leading institutes and sclentlsts that allgn wlth our scientific strategy.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 Obj•ctlv•s Icontlnuadl Our Performance Icontinuedl Develop our National Capabilities to ensure that they offer the UK research community high quality and high- value scientific service5 and training. The year brought specific challenges for the genomics team as they had restricted aC￿sS to the onsite laboratories due to social distancing and lockdown. This als(> impacted the national capability users and we saw fewer samples being received and proc8SSgd in the first half of the r8porting year. We repurposed some of our infrastructure and expertise towards COVID-19 testing, initially supporting the expansi(>n and automation ol region's NHS testing in collaboration with the University of East Anglia earfy in the pandemic, before setting up and op8rating dedicated facilities 8t El for 8symptom8tic testing of r&turning university students INorwich Testin Initiative). The year 8150 saw the cotnpletion of new facilities for ￿11 sorting, high-lidelity DNA sequencing and laboratory automation, placing the National capability in a stronger position to SUPPOrt the UK bioscience community as research acb"vrties gradually retum to normality. By the end of the year the team were wod(ing closely with the local Norfolk and Norwich University Pathology labs to Set up 8 new 581iv8 based tgsting lab within El, that will have the capacity to test up to 35,000 covid samples per week by mid 2021. The El Biofoundry continues to develop a sustsin8ble Tnodel ft)r providing access to facilities and expertise in lab-automation and synthetic biology to the UK bioscience and biotechnology community. It provided access to automated workflows and progress collaborations with researchers in academia and industry. El has dev8loped and maintained computing services that serve the scientifi community including". El's COPO dats broking platfom which was adopted by the Darwin Tree of Lrfe project IDTOLI htl s.'Ilwww.darwintreeoflile.or I, where all eukaryotic life in th8 British Isles will b8 s8qU8nced overthe next 10 years and Aquatic Symbiosis Gen(>mics IASGI projects, with over 10,000 samples uploaded Sin￿ its launch in October 2020. Working with the UK'S Designing Future Wheat project, we used gold-st8ndsrd annotat8d genornic data frorn Ensembl as 8 test case to scale up the GeneSeqToFamily Galaxy workflow to be used to find and categorise gene families in large plant genomes such as different wheat varieties, including the recently published 10+ wheat genomes. Despite the pandernic and Iwkdown, we have been able to continue remote training delivery, including the provision of computational cloud infrastructure to support training course participants. A number of activiti85 h8V8 allowed us to help shar8 best pr8Ctices, dat8, software, protocols, andlor other tools, bc)th nationally and intemationally. These include Galaxy training courses, ELIXIR workshops. and the development of Cyverse UK massive open online courses IMOOGsl in ¢o118bor8tion with Cyverse ALJstri8. We h8ve contributed to the integration of various lo()Is int() Galaxy, the development of Galaxy training materials and provided support for external issues not relevant to our own Galaxy instanc8s but those of the wid8r cornrnunity Our Advanced Training Programme moved lo a virtual model in April 2020, and w8 delivered 10 events reaching 101 people plus an additional 400 through networking and engagement events. The training team also assisted with the organisation of further Iraining events for the GROW Colornbia project. and supported the ELIXIR- UK All Hands and facilitated a workshop on Big Data Science f(>r a cohort of NRP Doctoral Training Programme PhD Students. Events locussed on training to address skills of the research community in single cell approaches to RNAseq dats analysis, fundamental programming linduding Python) and data management, plus networking e.g. Single Cell Symposia, the inaugural UK Conference of Bioinformatics and Computational Biology for which the 8irn was to bring together the communities working in genomics and structural infomats"cs. We developed new couises and supported visiting students with both remote and in-person internships for which the focus were dgveloprngnt of key genorni¢s and bioinforrn8ti¢s skills.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 Obl•ctlv•s Icontlnuadl Our P*rfom)anc• Ieontlnu￿l Continue to communlcate our sclence through our publlc engagement program to a wlder audience, promoting the importance of publicly funded ￿Search to the general public. The Communications Team had a productive year and supported the digital presence and communication ol the Norwich Testing Inits'ative, as well as wider promotion ol the Instilule's response to the pandemic. National media coverage was achieved at various points through the year around mass testing, swalled 'silent spreaders,, and on vaccination. Social media became more important than ever as a tool for reaching our community, our work in digital media and on our website leading to a significant rise in engagement and followers compared with previous years. In-person public engagement events were cancelled or postponed, limiting our output but by creating opportunities lor public engagement through multimedia. particularly on social channels we were able to deliver a suc￿sSful pilot citizen science survey for a Royal Society event. completed by hundreds of bee hotel owners across the UK. We also adapted some previous work on the 'Bee Trail, into a game, which we're excited to launch at the Royal Society event in July 2021. We also expanded the team to deliver Public Engagement on our'Barcoding the Broads, project. as part of the Darwin Tree of Life programme. Looklng Ahead El's objectives for 2021122 are to.. Continue the growth and development of our world leading investigator-led research program, continue to publish high quality scientific outputs and diversify our income streams. Build strong industrial collaborations so that we are aligned lo the Government's strategy and so we can achieve impact from our research. Strengthen our par￿ershipS through collaboration with worfd leading institutes and scientists that align with our scientific strategy. Develop our Nation81 Capabilities to ensure that they offer the UK research cornmunity high quality and high-value saentilic sewi￿$ and training. Continue to corntnunicate our science through our public engagernent piogratn to 8 wide audience, promots'ng the importance of publicly funded research to the general public. iv.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 FINANCIAL REVIEW Income income fi()m cash deposits in the year was £54,000 Total incoming resour￿$ for the year were £11.1m 12020.. £125,000). 12020.. £12.6ml. which was down on the previous year Grant proposals due to lower capital grants. Inc()me excluding capital During the y88r, El res88rcher5 submitted grant grants was £10.2rn 12020.. £9.9ml, as higher BBSRC proposals with a sponsor value of £7.3m 12020.. strategic funding offset lower other generated income. £20.8rn1 and were awarded grants with a value of El's principal sponsor is the Biotechnology and £1.7m12020.' £1.8ml. Biological Sciences Research Council IBBSRCI. which contributed 87Q/D of tot81 incorning r8sourc8s 12020.. Reserves policy 85¢/ol. Oihei major sources ol funding were UK El's r8serv85 ar8 h81d to support financial solv8ncy, universities and research organisations and the EU. manage uncertainty and fund future activities. The level Expenditure of resetves required by El is therefore determined by Total resources expended amounted to £12.5m12020'. reference to.. £14.1rnl, which was down on the previous year due to Future operational and capital expenditure the impact ol COVID-19 on activity and lower requirements in the Business Plan to March 2022., depreciation. Staff costs accounted for £5.2m 141°/.1 Potential financial risks identified in the Business 12020.. £5.1 rn,. 36°/ol of expenditure with depreoiation of Plan and Risk Register, tangib18 ass8ts accounting for £3.1m 125P/¢l 12020.. Potential funding required for strategic £3.6m', 26¢/ts1. InV8Stm8nts not inoluded in the Busin8ss Plan., Net Movement in Reserves Working capital I liquidity requirements. El recorded an increase of 20.7m in unrestricted Unrestricted reserves that have been designated by reserves 12020.. decrease of £0.9ml due to higher the Board for specific purposes are shown in separate BBSRC strategic funding in the year. designated reserv8S. Restricted reserves decreased by £2.1m12020". £0.6ml Reserves position due to depreciation exceeding capital funding in the year, and drawdown of capital reserves. Total reserves decreased by £1.4m in the year to £21.6rn12020'. decreased by £1.5m to £23.Oml. Subsidiaries and Related Parties Restricted reserves decreased by £2.1m to £9.8m El's trading subsidiary. Earlham Enterprises Limited Iformerfy Genorne Enterprise Lirnitedl, contributed an 12020.. decreased by £0.6m to £11.9ml. Restricted operating profit of £255,00012020'. £136,000). reserves include design8tgd reserves of £0.9m for advance capital funding and project funding from El has 8 25/0 interest in NBI Partnership Limited BBSRC and £0.4m for advance strategic funding. I"N81P"I. NBIP supplies support services to El and the other Norwich Institutes (John Innes Centre, Quadram Unr85trict8d reserves increased to £11.8m 12020.. decreased to £11.1ml. Reserves of £6.9m have been Institute Bioscien￿ and The Sainsbury Laboraloryl. designated by the Trustees in respect of the following.. Capital expenditure Capital expenditure in the year of £1.7m12020'. £1.8ml related to InVgStmgnt in s¢igntrfic and compLrting equiprnent I£0.4tnl and building facilities1£1.3ml. Cash Ctrfunding lor the Institute's strategic research prograrnrn85', Planned strategic research investment,. and Planned capitsl investment in leadingedge sequencing and high performance computing t8chnology. General unrestricted reserves at March 2021 were £4.1rn, £1.6m above the minimum general reserves target set by the 8oard of £2.5m. Group cash at 31 March 2021 was £15.5m 12020.. £14.9ml. The cash increase in the year reflects the increase in unrestricted reserves in the year. El deposits its cash wth UK registered financial institutions that meet its credit rating policy. Investment

Earlham In8tltut8 | Annual Report and Accounts | March 2021 RISK ASSESSMENT AND MANAGEMENT The Board of Trust88s is responsible for ensuring there are eff8Ctive and adequate risk managerngnt and intern81 control systems in place, and confirm that the major risks to which the Institute is exposed have been reviewed and prO￿dureS established lo manage those risks. The Audit and Risk Committee agrees an annual risk-based internal audit plan which covers major iisks identified by tmanagement and Trustee5. It receive5 report5 fro inlemal auditors on the effectiveness of internal controls, progress against the internal audit plan and progress on recommendations made in reports. The Board ￿vIewS a full risk report 8nnually, including a 'heat rnap tracking major risk5. Principal risks and uncertalntles The principal risks and un￿rtaIntIeS facing the Charity a￿ considered to be.. De$¢ription of Risk Management of Risk

strategic funding 15 reduced due a Regular rnoniloring of scientific perfortnance reduced fvnding envelop that we can bid against strategic progratnrne objective5. into through public sector spending * Regular ¢ommuni¢ation with UKRI- BBSRC pre55ures or wor 5cientrfic PerfO￿an to report performance and ensure strategic Competitive grant funding is r8duced due 81ignm8nt of r8search programmes. to s￿nsOr budget reductions or failure to > Monitoring of perfOr[nan￿ of CO￿pet￿]Ve win n8w project funding. grant submisS￿n$. El is unable to keep pa¢e with > Bidding into Capital Grant opportunities to developments in technology underpinning refresh platforms. its s¢ien¢e. Technology strategy kept under regular Funding andlor cost recoveries are review and fvnding opportunities identified inadequate to 5UStain improve and pursued for technology inveslrnent5. technologyfacilities ￿e￿ssary lo supwrt > El h88 reseNes that enable il lo move scientffic objectives. quickly when t8chnology 8nhancements b8com8 available. Ri$k area Future BBSRC and other spon50r research funding Technology Inve$tment Staff retention and recruitment El is unable to retain or attract suitably * Strategy and action p18ns in place, skilled stsff to enable rt to sustsin its monitored by Strategic Hurnan Resour(xs scientffic perf0rrnan￿. Group. In addition to SC18ntific impact, this risk * Career development programmes in plac8to are8 could al80 have an impact on the support high potential staff. level of funding th8 institute IS 8b18 to > Action following feedback frotn annual staff attract. survey. Performanc8 Manag8rnent pro(*sses in pla(x. Regular dialogue with UKRI BBSRC and other key stakeholder5 on risk5 and emerging issues with respect to potential changes in arrangetnents. Kept abreast of risks and potential impact from staff leaving EIIUK, and ensure we prepare for th8 new immigration and visa process post BREXIT. Realign overseas programmes into new an evolving funding pr￿ramme$ as they arise. A major systems failure diswpts scientffjc * Business Continuity and Disaster wovery sear¢h programmes. plans in pla￿ and tested periodically. A major incident datnages El's reputation Appropriate Insuran￿ arrangernents are in impacting on future funding an pla￿. Ilaborative opportunities. El fails to ¢omply with sponsor grant k El Is subject to regular reviews of its grant qU1￿MentS ￿sUIting in a material compliance processes from sponsors and financial Impa¢l. the Research Councils UK internal auditors. El fails to deliver its science programme k El active business continuity group due to th8 implications of COVID-19 on prioritised the safety of ils st8ff during th8 access to sit8 and or slafflstudenis, lockdown period. We reopened critical wellbeing. onsit8 SCi8nc8 in M8y 2020 and wer8 granted funding extensions by UKRI to deliv8r th8 scienc8 progr8mmes that Ware impact8d. Impact of lezving EU or other major international funding programrne cut5 El is not able to access EU programme funding or participate in EU research collaborations. El is not able to recruit or relain r8S8arch8rs from EU member countri88. El is not able to continue with its intemational fvnding prograrnrnes due to Government Overseas Development budgets Cuts. Major buslness IntÈrruptlons or lo of equipment or computer $y$tems Compliance with $pon$or fundlng requlrements Impact of COVID-19 on science programmes

Earlham In8tltut8 | Annual Report and Accounts | March 2021 TRUSTEES, REPORT STRUCTURE, GOVERNANCE AND MANAGEMENT Membars and Patrons Organisation and gov•manc• El is incorporated in England and Wales and is a company limited by guarantee (registered number 0685553318nd 8 registered charity Inumber 11362131. El is governed by its Memorandum and Articles of Association, adopted 20 December 2016. Th8 financial st8tern8nt5 have be8n pr8pared in accordance with the Charities Act 2011, the Companies Act 2006 and Accounting and Reporting by Charities. statement of R8commended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland IFRS 1021. The Members ol El are.. UK Research and Innovation - Biotechnology and Biological Sci8nces Research CoLJnciI I"BBSRC"I', University of East Anglia I'UEA.)", The Chair of the Board of Trustees. Board of Trustees The Board of Trustees cornprises the Chair and up to eight additional trustee directors. The Trustees who Se￿ed during the year and up to the date of signing these financial statements were as follows.. rustees Sub-committees Changes during period At date ofReport.- Professor Dame Janet Thornton (Chalrl Dr Ala5dair Macnab Professor Peter Holland Profassor Thomas Richards Ms Amanda Tag9 Mrs Andrea Finègan Professor Jean Beggs Profassor Edward Louis Professor Philip Gilmartin AC (Chairl, Rem Com Rem Com AC AC, Rem C(>m (Chairl Rem Com AC lup to 12 October 20211 AC (from 12 October 20211 Audlt Commlttee are in regular contact with the Institute Director and The Audit Committee is responsible lor oversight of the executive team and receive presentations on key areas areas of audit,. financial reporting., regulatory of activity. compliance., intern81 syst8ms and controls lincluding Trustee remuneration the integrity ol financial controls) within El. The Audit El remunerates trustees where the Board Considers Committee reports lo El's Board, making that payment is necessary to attract trustees with recommendations for Board consideration where specialist skills and experience. The power to necessary. remunerate trustees is included in El's Articles of Remuneration Committee IRem Com) Association and has been approved by the Charitie5 El's Rernuner8tion Cornmittee is responsible for Commission. Details ol trustee remuneration in the advising tsn the remuneration and policy on executive year are included in noie 8 of the financial statements. pay and performance packages. It reports to the Board and is comp058d of fourTrustee Director5 r8presenting the scientific and commercial expertise. The Scientific Advisory Board ISABI The SAB, chaired by Prof Simon Hubbard, is r8spon5ible for providing strat8gic advic8 on i55U85 relevant lo El's scientific mission and science programmes. Recruitment, induction and training of Trustees, The Institute advertises n8tion8lly for prospective Trustees to ensure appropriate expertise on the Btrard is maintained. The Institute will also approach individuals thought to have the right skills. The Board strives through its recruitment to keep good diversity within the Board membership. An induction programme h8s been put in pla￿ for newly appointed Trustees and is kept under review and updated where appropriate. In addition, the Trustees Decision making and key management The El Board has delegated the day-to-day rnanagement of the charilable cornpany to the Director and the Executive Teatn, who are considered to be the key management personnel for the insts"tute".

Earlham In8tltut8 | Annual Report and Accounts | March 2021 Direttttrr furtherance of the NRP Enterprise Vision. El is entitled to receive a share of certain profits generated by AIP, however it has no liability for losses or in the event ol insolvency. AIP has not yet generated any profits. BBSRC Professor Neil H811 is the Director of El. He has previously led research gr(>ups at the Sanger Institute, The Institute for Genomic Research and The University of LiverFK)oI. Director of Op8r8tions Sarah Cossey is the Director of Operations, professional accountant and project manager with 20+ years, experience across the public and private sector. Head of Genomics Pipeline Dr. Karim Gharbi is a biologistwith over two decades of experience genomics and nexl-generation sequencing INGSI and has previously led NGS in Edinburgh G8nomic5 and University. Head ofpiant Genomics BBSRC is a member tsf the charitable company. El is strategically funded, along with seven other institutes, by BBSRC. BBSRC supports El vi8 Strategic 5-y8ar funding programmes, competitively won project grants and capital funding for infrastructure and technology investtnents. The principal teirns and conditions under which BBSRC provides its funding are set out in El's Institute Grant Agreement. 88SRC is part of UK Research and Innovation IUKRII, an organisation that brings together the UK'S seven research councils. Prof. Ant H811 pr8viously he h81d the Holbrook G8sk811 Employees Chair ol Botany at the University of Liverpool and research lead for the Institute of Integrative Biology and El staff that joined before 1 October 2011 were employed by BBSRC up to 1 October 2017, when they Director at thg Centre for Genomic Resgarch ICGRI transf8rr&d 8mployment to th8 In5titut8 under TUPE. and acadetnic lead of the Liverpool Genemill. Head of Research Faculty Office Transferred employees retain their membership of the R8search Qouncils Pension Scheme IRCPSI, where Dr. Christine Fosker has worked in the field of applicable, with El becoming an admitted employer in Genomics lor 20 years, beginning her career working the scheme. The RCPS is a defined benefit scheme on the Human Genome Project at the Sanger Centre. funded frorn annual grant-In-8id on a p8y-as-you-go She received her Ph.D. from the University of basis. El accounts for the scheme as il it were a wholly Cambridge and the Welleome Trust Sanger Institute defined contribution scheme. Head of Research e-infraslruGIu El has recruited all new staff frorn October 2011 on its own terms and conditions, covering basic pay and allowances, contractual payments, tax, Nl, and liabilities for pension contributions and r8dundancy. Such staff are eligible to join a defined contribution scheme. El employs a nurnber of posilionsjoinuywlh UEA. Staff ar8 8mploy8d und8r El terms & conditions, but are eligible to join The University Superannuation Scheme IUSSI. El is obliged to pay the prevailing employer contribution rate foi staff in the USS, however it has no liability lor scheme funding deficits. Communication Dr. Rob Davey has 15+ years in bioinformatics and software development. He leads the research e- infrastructure n8tion81 Capability, and data rn8nag8ment eletnents of two core research programtnes. Related Parties Subsidièries ènd Related Pathes El's trading 5ub5idi8ry - Earfharn Ent8rpris8s Limit8d Ifomerfy Genome Enterprise Limitedl- contributed an operating profit of £255,00012020'. £136,000). NBIP- Associète El provides all staff with relevant infomation, and seeks their views on matters ol common concern through El has 8 25P/ts Int8r85t in NBI Partnership Limited direct wmmunication and through line managers. INBIPI. NBIP supplies support and administrative Priority is given to ensuring that employees are aware se￿iceS lo El and the other Norwich Institutes lJohn of all significant matters affecting El's position and any Innes Centre, Qu8dram Institut8 Bioscience and The significant organisational changes. Sainsbury Laboratory) on a not-for-profit basis. NBIP fully recharges its costs to the four research institutes Equality and Diversify and awordingly it gener8tes no profit or loss. It is El's policy to provide equal opportunities to job Anglian I￿n0V8h0n Partnership LLP (AIPI applicants and ernployees of any race, nationality, ethnic origin, marital status, religion or belief, gender, El became a member of AIP on 7 August 2012 through disability. sexual orientation, age or employment status. its 100Qk sub5idi8ry, E8rfham Ent8rprises Limited. AIP El does not condone or tolerate any form of is responsible for the management and development of discrimination in its recruitment or employment the Norwich Research Park INRPI estate and for the practices. All employees and applicants are treated on 10

Earlham In8tltut8 | Annual Report and Accounts | March 2021 merit, fairly, with respect and dignity, reccyJnised as individu81s and valued for the contribution they make, provided lair and equal actsss to training, development, reward and progression opportunities and are accountable for the impact of Iheir own behavi(>ur and actions. Al El's policies ft)Ilow these principles. El is aware of its statutory duty to support the employment of disabled pers()ns where possible, both in recruitment and by retention of employees who become disabled whilst in the employment ol the ¢harit8ble ¢omp8ny, 85 well 8s generally through training and career development. Health & Safety El aims to s8fegu8rd and itnprove the health, safety, welfare and security of its empl()yees and the health and safety of visitors. El aims lo create an atmosphere wh8r8 h8alth and safety matt8r5 are paramount considerations and consults with employees and their representatives on health and safety matters. Going Concern The finanual statements have been prepared on a From late March 2020 until June 2020, the Institute's going conTrrn basis which the Trustees consider to be facilities were closed to all staff and students, except for appropriat8 for the following r&ason5'. 8ss&ntial work and activity supporting Covid-19-r81at8d testing and research. During this period, El staff and students have been able to operate effectively from home and, with f8cilities b&ing re-opened progr8ssively Sin￿ then, the Institute has been able to successfully maintain its research programmes and projects with inimal financial imp8Ct. The Institute has tx)nsider8d the potential financial impact of continued restrictions The Institute is reliant on its strategic programme for the next 12 rnonths. including the potential for 8 funding from BBSRC, which was £6.3m in the year further lockdown. Taking into account experience to 12020.. £5.2tnl. BBSRC ha5 confiirned continued date, business continuity arrangements and financial strategic funding of £5.2m lor the year lo March 2022 projections. the Institute considers the risk of a plus provision81 funding al this level for a furtheryear to significant financial irnpact frorn Covid-19 to be low. March 2023 subject to the next government spending review. The Institute expects its funding for the year to March 2023 to be confirmed in late 2021 based on feedback frotn 88SRC. The Trustees have prepared cash flow forecasts for the period to March 2026 which indicate that, taking account of reasonable possible downsides and the anticipated irnpad of COVID-19 on the operations and its financial resources, the Insts-tute will have sufficient funds to meet is liabilities as they fall due lorthat period. Consequenuy, the Truste85 ar8 confident th8t th8 Institute will have sufficient funds to conts.nue to meet its liabilities as they fall due for at least 12 months from the date of approval of the financial statements and therefore have been prepared the finanaal statements on a going concem basis.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 STATEMENT OF RESPONSIBILITIES OF THE TRUSTEES OF EARLHAM INSTITUTE IN RESPECT OF THE TRUSTEES, ANNUAL REPORT AND THE FINANCIAL STATEMENTS The trustees 8re responsible for preparing the Trustees. Annual Report and the financial statements in accordance with applicable law and regulations. Th8 trustees 8re responsible for the m8intenan¢g and integrity of the corporate and financial infomation included on the charitable companys website. Legislation in the UK governing the preparation and Company law requires the trustees to prepare financial disseminatitsn of financial statements may differ from stat8Tnents for each financial year. Und8r th8t18w they legislation in otherjurisdictions. have are required to prepare the group and parent company financial staternents in accordance with UK Insurance disclosure Accounting Standards and 8pplic8ble law (UK Generally Accepted Accounting practi￿), including The Institute maintains liability insurance for its FRS 102 The Financial Reporting Standard applicable trustees, with an annual aggregate cover limit lor all in the UK and Republic of Ireland. claims against them in that capacity. The Iruslees have also been granted a qualifying third party provisitsn under section 233 of Companies Act 2006. Neither the Institut8's ind8mnity nor insur8nC8 provid8s cover in th8 event that a trustee is proved to have acted fraudulently or dishonestly. Under company law the trustees rnust not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the group and ch8rit8bl8 company and of th8 group's result for that period. In preparing each of the group and charitable company financial statements, the trustees are required to.. Public benefit The Trustees are satisfied they have eomplied with their duly in section 4 of the Charities Act 2011 to have due r8g8rd to public benefit guidanc8 published by th8 Charities Commission. Based on this guidan￿, and as described in this Trustees, report, the Trustees believe the activities of El to be charitable in nature. $818Ct suitable acwunting policies and then apply thern consi5tently', make judgements and estimates that are reasonable and prudent., state whether applicable UK Aeeounting Standards have been followed, subject to any material departures disclosed and explained in the financial The trustees confim that.. staternent5,' and assess the group's and the d)aritable company's ability to continue as a going concern. disclosing. a5 applicable, matters related to going concern., and use the going concem basis of accounting unless th8y either intend to liquidat8 the group or th8 charitable companyor to cease operations, or have no realistic alternative bul to do so. Disc105ure of information to auditor so far as each trustee is aware, there is no relevant audit information of which the Company's auditor is unawaie, and the trustees have taken all the steps that they ought to have laken as trustees in order to make thetM5elves aware of any relevant audit information and to establish that the Company's auditor is aware of that information. The trustees are responsible lor keeping adequate accounting records that are 5LrfficiBnt to show 8nd explain the charitable company's transactions and disclose with reasonable accuracy at any time the rinancial position of the charitable cornpany and enable them to ensure that its financial statements comply with On behalf of the Board the Companies Act 2006. They are responsible for such internal control as they deterrnine is necessary to enable the preparation of financial statements that are free from rnaterial rnisststernent, whether due to fraud or error, 8nd have g8n8ral r85ponsibility for taking such steps as are reasonably open to them to safeguard the assets of the group and to prevent and detect fraud and Janet Thornton, Trustèa Dlractor other irregu18rities. 7 December 2021 Independent auditors Larking Gowen LLP have been appointed as auditors and a resolution has been passed by the Board, COn￿rnIng their appointment as auditors. 12

Earlham In8tltut8 | Annual Report and Accounts | March 2021 INDEPENDENT AUDITOR'S REPORT TO THE MEMBERS OF EARLHAM INSTITUTE Opinion period of at least twelve rnonths from when the financial ststements are authorised for issue. We have audited the financial statements of Earlham Institute (the 'parent charitable company'l and its subsidiaries (the 'group'l for the year ended 31 March 2021 which comprise the Consolidated Slalement ol Financial Adivities, Consolidated and Charitable C()mpany Balances Sheets, Consolidated Statement ol Cash Flows and Notes to the Accounts, including significant accounting policies. The financial reporting frarnewotk that has been applied in their preparation is applicable law and United Kingdom Accounting standards, including Fin8nci81 Reporting Standard 102 The Finanaal Reporting Standard applicable in the UK and Republic of Ireland Iunited Kingdom Generally Accepted Accounting practi￿). Our responsibilities and the responsibilities of the trustees with ie5pect to going con￿rn are described in the relevant sections of this report. Other Infom)atlon The other information comprises the information included in the trustees, annual report, other than the financial st8t8ments and our auditor's r&port thereon. The trustees are responsible for the other infomation contained within the annual report. Our opinion on the financial statements doe5 not cover the othei information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon. Our responsibility is to read th8 Other information 8nd, in doing so, consider whether the other inlomation is materially inconsislent with the financial statements or our knowledge obtained in the course of the audit or otherwise appears to be materially misstated. If we idents'fy such material inconsistencies or apparenl mat8rial mis5tatetn8nts, we are r8quired to d8t8rmin8 whether this gives rise to a material misstatement in the financial statements themselves. If, based on the work we have p&rformed, we conclude that there Is 8 rTl8terial misstatement ol this other inlomatitsn, we are required to report that fact. In our opinion the financial statements.. give a true and fair view of the state of the group's and parent ¢harit8ble company s affairs as 81 31 March 2021, and of the group's incoming resources and application of resources, including its incorne and exp8nditur8, for the year then &nd&d., have been properly prepared in accordance with United Kingdom Generally Accepted Accounting Practice.. and have been prepared in accoidance with the requirements ol the Companies Act 2006. Basis for opinion We have nothing to report in tt)is regard. We conducted our audit in accordance with International Standards on Auditing IUKI IISAS IUKII and applicable Opinions on other matters prescribed by the Companies Act 2006 18w. Our responsibilities underthose standards ar8 furth8r described in the Auditor's responsibilities for the audit of the financial statements section of our report. We are independent of the group and parent charitable cotnpany in accordance with the ethical requirements that are relevanl to our audit of the financial slaternents in the UK, including the FRC'S Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit eviden￿ we have obtained is sufficient and appr(>priate to provide a basis for our opinion. In our opinion. based on the work undertaken in the course of the audit.. the information giv8n in the tru5t88s' r8POrt (incorporating the strategic report and the directors, report) for the financial year for which the financial st8t8Tn8nts are prgp8red is ¢onsist8nt with the financial statements., and the strategic report and the directors, report have be8n prepared in accordanc8 With applicab18 18gal requirements. Concluslons rèlatlng to golng concèrn In auditing the financial statements, we have conduded that the trustees. use of the going con￿rn basis of accounting in th8 pr8par8tion of th8 financial st8tem8nt5 is appropriate. Based on the work we have perfomied, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may ¢8st significant doubt tsn the group's or parent charitable company's ability lo conts'nue as a going concern for

Earlham In8tltut8 | Annual Report and Accounts | March 2021 Matters on whlch we are requlred to report by exception aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statetnents. In the light of the knowledge and undersianding of the group and parent charitable company and its environrnent obtained in the course of the audit, we have not identified material misstatements in the strategic report and the directors. report. Itregularitie5, induding fraud, are instances of non- compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to d8t8Ct mat8ri81 mi55tat8ments in r85PeCt of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities. ineluding fraud, is detailed below. We hav8 nothing to r8POrt in r85P8Ct of th8 following matters in relation to which the Companies Act 2006 requires us to report to you if. in our opinion.. adequate accounting records have not been kept by the parent charitsble cornpany, or returns adequate for our audit have not been received from branches not visited by us., or thg parent charitable wmp8ny s financial statern8nts are not in agreernent with the accounting records and retums., or certain disclosures ol directors, remuneration specified by law are not made., or we have not reTrived all the infom)alion and explanations we require for our audit. Due to the field in which the group op8rates, we identrfigd the areas most likely tts have a direct material impact on the financial statements as compliance with UK tax 18gis18tion, UK 8ccounting Standards, UK charity law and the Companies Act 2006. In addition, we considered the provisions of other laws and regulations which whilst not having a direct imp8d on the fin8n¢i81 st8terngnts, are fundamental to the group's ability to operate including health and safety,. employment law. and compliance with various other regulations relevant to the conduct of the group's operations. Our approach to identifying and assessing the risk of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, included the following.. Responsibilities of trustees As explained more fully in the trustees, responsibilities st8tgTn8nt set out on pagg 12, the trustees Iwho ar8 also the directors of the parent charitable company for the purposes of company lawl are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and lor such inlemal control as the trustees determine is necessary to 8nab18 th8 pr8P8ration of financial statern&nts that are free from material misstatement, whether due to fraud or error. Enquiries with management about any known or suspected instances of non-compliance with laws and regulations. accidents in the workplace, potential litigation or claims and fraud., Reviewing legal and professional fees to confim matters where the group engaged lawyers during the y88r', Reviewing financial statement disclosures and tax matters, and testing to supporting documentation to asse5S c0tnpli8n￿ with applicable laws and regulations., Reviewing board minutes and any relevant corr8spond8nce with extem818Uthoriti&s', Challenging assumptions and judgements made by management their significant accounting estimates, particularfy in relation to the recognition of grant income., and Auditing the risk of management override ol controls, including through testing journal entries and other adjustments for appropriateness, and evaluating the business rationale of any significant transactions outside the normal course of business. In preparing the financial statements, the trustees are responsible for assessing the groups and parent charitable company's ability to continue as a going concern, disclosing. as applicable, matters related to going concern and using the going wncern basis of accounting unless the trustees either intend to liquidate the group or parent charitable company or to Trase operations, or have no realistic alternative but to do so. Auditor's responsibilities for the audit of the financial statements We h8V8 be&n appointed auditor under the Compani85 Act 2006 and report in accordance with this Act. Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from tnaterial misstatetnent, whether due to traud or error, and to issue an auditor's report that includes tsur opinion. Reasonable assurance is a high level of assurance, but is not a guar8nt88 that an audit conducted in accordanc8 with ISAS IUKI will always detect a material misstatement when itexists. Misstatements Can arise from fraud orerror and are considered tnaterial if, individually or in the Due to the inherent limitations of an audit, there is a risk that we will not detect all irregularities, including Ih(>se leading to a material misstatement in the financial st8t8ments or non-complisnce with regulation. This risk increases the more that compliance with a law or regulation is removed from the events and transactions reflected in the financi81 statements, 85 we will be 1855 likely to become aware of instances of non-compliance.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 The risk is also greater regarding irregularities occurring due to fraud rather than error. as fraud involves intentional contsaltnent, forgery, collusion, omission or misrepresentation. state lo them in an auditor's report and for no other purpose. To the fullest extent perrnitted by law. we do not accept or assutne responsibility to anyone other than the charitable company and the charitable company's members as a body. for our audit work. for this report, or for the opinions we have formed. A further description of our responsibilities is available on the Financial Reporting Council's website at.. https'.Ilwww.frc.org.LJklOur-WorklAudiVAudit-and- assUrancelStandards-and-guidan￿1standards-and- guidan¢e-for-auditorslAuditors-responsibilities-for- audiVDescription-of-auditors-resporisibilities-lor- audit.aspx. This description foms part of our auditor's report. LLP Anders Rasmussen FCA (Senior Ststutory Auditor) Use of our report for and on b8half of Larklng Gowen LLP This report is made solely to the charitable company's tn8mbers, as 8 body, in accord8nC8 With Ch8Pt8r3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the charitable mp8ny s rnemb8rs those matters we ar8 required to Chartered Accountants Statutory Auditors Norwich 14 Dec8Tnber 2021

Earlham In8tltut8 | Annual Report and Accounts | March 2021 FINANCIAL STATEMENTS CONSOLIDATED STATEMENT OF FINANCIAL ACTIVITIES FOR THE YEAR ENDED 31 MARCH 2021 I INtJ AN HNV tAVtP4LII I Utr<& ALLOUN I Unrestr1d￿ Restricted Restrid funds fund8 cs £o(M) £￿0 Total Total 2020 Mjle £000 Incornp In¢orne fr¢wn charitable aclivifies Grant In¢om- BBSRC Grant In¢onE- Other other Re￿[ch lrtotnè Capital furKJing- BBSRC 8,466 566 386 1,192 7,979 317 607 2.718 *)1 991 In¢orne from other tradingaclivilies Trading Ir￿ P£ntal iT￿r 409 Investn7entincoffle 10 127 Olher£Ener8tedincome 422 Total I￿orr 9,233 991 12.608 Expenditure Charitabl& acti￿tieS Paising funds Tradiry 15251 18,7181 13,(fAI 112.307) 11221 11221 1831 1831 113,7661 12221 Total ex ndrture Net ex enditur8 for the 515 Other tr3rEfers Capital trarEfers 20 20 1.258 17151 11.2581 715 Net mvemÈnt in funds 743 Funds br￿ght fo￿rd 11.053 2,032 22,989 24.484 Funds carrled fcnvard The Consolidated Statementof FinancialActivilies I"SoFA"l includes all gains and losses re￿gnised in theyear. All intotning resources and expenditure relates to continuing activities. The notes on pages 19 to 31 form part of these financial ststements.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 CONSOLIDATED AND CHARITABLE COMPANY BALANCE SHEETS AS AT 31 MARCH 2021 Group (>wp Company CcThpany 2020 £o(M) 2021 £000 2020 Note Fixed &ssels Tar¥jIb￿ assets Intary1b￿ 8S8eL8 10.843 12 9,350 10.843 12 12 Current assets Strtk8 Debtors Cash at bank arKI in Fwnd 14 15 16 163 3.164 1S461 18,7B6 163 3,005 15.329 18,497 2.071 14.945 17,102 1.947 14.923 16,9 Cmnl 118biliti8s cr￿ltOrs". a[￿￿TrtS faling due ￿1th1￿ one year 16,51n 14.wl 16,4831 4,9541 Total net curreth assets 12.134 11. Total assets le55 currerrt liabilit￿$ 21,W21 21.364 22,851 Total net asset8 The fvjnds of the charity Restricted funds Fi)d asset r8saN DeW9n8￿ resepEs rnerJ rese Total restricted funds &546 8,556 861 428 9,914 1.651 381 11,946 1.651 381 11,W36 428 9,835 Unrestrictecl funds FiY2d asset reseThe De&gn8ted r8sews rner31 rese Total unrèthcted funds 951 5,572 804 6,B77 3,838 11,519 941 5.572 877 4105 11,786 11.053 10, Total funds A separate incom& and expenditure account has not ￿en presentèd for El as this is exempted by S8ction 408 of th& Companies Act 2006. The loss after lax of El was £1.487,00012020.. loss of £1.413.0001 Thefinancial slaternenls on pages 16to 31 were approve(I by the Board of Trustees on 7 December 2021 and were signed on ils behalf by.. Janet Thornton, Trustse Director Th& accompanying notes fom part ofth8se financi81 stat&ments.

Earlham In8tltut8 | Annual Report and Accounts | March 2021 Company registration number.. 06855533 CONSOLIDATED STATEMENT OF CASH FLOWS FOR THE YEAR ENDED 31 MARCH 2021 Total 2021 £000 Totsl 2020 Cash lows from op8ratlng actfvrtbs: Orratiw d&ficil Interest receivab Depreciati￿ and ar[￿tis￿￿On Capital gr8nLq r8cei¥ed Loss on disposal of tangible assets IlncreaseVDecrease in 5twks Incr&asÈ in d8btor8 Increase in creditors 11.3681 1561 3,064 11,4951 3.6(Y 12,7181 169 11.087) 1.029 Net cash ovided at act￿leS 996 256 Cash Fbws trom Inve8tlng actfvttl8S'. Interest receid Purchase of tangibkg assets Capital grants reCeI￿d Proc88d8 frcm Sa￿ of tangib18 as8ets 56 11,7281 1,192 127 2.718 Net cash used In rovlded Investkn actlvtt*8 Chan 111 cash cash a￿Trts in the re ortin iod 516 1.291 Cash and cash eqUIva￿trtS at beginnir¥J irflhp peri( 16 14,945 13,654 Totsl ¢a8h and ¢a8h ulvalents at tho 8nd ofth8 The rnovement in nel debt forthe current and prior year 15 identlQ31 to the tni)vemen15 in ￿$h flow set oul above. Th& accompanying note8 form part ofthes& financi81 stat&ments.

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS ACCOUNTING POLICIES Ba$is of preparation The group financial statements hav& beèn prepared under the hiStOr￿al cost convention and applicable accounting stsnd3rds. Th8y have also been prepared in accordance with Accounting and RÈporting by Charities", Statement of Recommended Practice applicable to charities preparing their accounts in accordance with th8 Financi81 Reporting Sl8nd8rd applic8bl8 in the UK and Republic of Ireland IFRS102F (Charities SORP IFRS10211. the Financi81 Reporting Standard applicable in the UK and Republic of Irel8nd IFRS1021 and th8 Comp8ni8s Act 2006. The principal accounting poI￿leS adopted in these financial stslements. which have been consistently applied. are.. Basis of Consolidation The Gonsoli(lated financi31 statetnents incorporate the financi31 stslements of El and 811 its subsidiary undertakings in accordanc& with Financial Reporting Standard I'FRS'I 102 "A￿U￿tIng for Subsidiary Undertakings" El is one of four meTnbers of NBI Partnership Litnited I"NBIP"I. The group accounts for NBIP as an associate. although in pr8CtIC8 the t￿paThy make8 no profil or Ioss 8nd has n81 asset8 of NIL. therefo￿ has no impact on the Group financial 8ts1ements. financial projections. the Institute considers the risk of a significant financi81 impact froKn COVID-19 to be low. Consequently. the Trustees a￿ confident that the Institute will have 8uffia8nl fund8 to continue lo me8t its liabilitie8 as they fall due for at least 12 months from thè date of approval of the financial statements 3n(I therefore have been prepared the financial 8tatemenl8 on 8 going conc8m basis. Judgements in applying accountlng pollcles and k8y sources of estlmatlon Pr8paralion of th& financial Slater￿n1$ r8quir8 managem8nt lo tnake significantjudgements and estitnales. The iletns in the financial 8tst8menl8 wher& th888 judgements and 88timates have been made include". Depreciation, which has b8en charyed in line with th& a¢¢ounting policy below. The amount of depreciation Gharged 8nd nel book value of the 8ssels is included in Note 11. Income Charitable grant incotne represents grants received and receivable in the year from outside granting bodies and other mlscellan&ou8 Incom&. Grants that pro¥idÈ core fundlng are recognise(l in the year in which entitlement passes. Grant funding received lo undert8ke research is recognised in the year in vA)ich thè obligation is fulfilled. Grant funding 18 released to match extenditure incurred during the ye3r together with any r8lal8d contribulions towards overhead cost8. Other charitable research income represents non-grant ￿venUe frorll collabor8tive research projects with other acaderllic in81ilution8 and olh&r 8ci8ntific services. Revenue is recognised in the year in which the obligation is fulfilled. Capital grants are recognised when enlillement passes. which is typically on recèipt. whe￿ capital funding includes IÈTrns and con(lilions that must be rllel before there is unconditional enlitlemenl, the grant income 18 recogni88d as those conditions a￿ tnet. which usually results in capital funding being rècognised to match the capitsl costs incurred. Inv8slm8nl Income r8lale8 to inter88t r8ceivab18 from treasury deposits and relat￿ party loans. The interest is retognised in the year in which it is e8rnl. Other income relates lo mi8c8llanÉou8 income. R&v8nu8 Is recogni8ed In th& y&ar in The financial statements of all group undert3kings are made up to 31 March 2021. A $8p8ral& income and expenditur& aecount has not been presented for El as pertnitted by Section 408 of the Companies Act 2006. The loss after tsx of El was £1.487.000 12020.. £1,413,000) for the year. Golny concem Thefinanci81 statements have been prepared on a going COn￿M ba8is which th& Tm8188s ￿nSIder lo b& appropri8t8 for th8 following re3sons'. The Trustees have prepared cash flow forecasts for the period to March 2024 which indicate that. tsking account of reasonable possible downside8 8nd the anticipated Impact of COVID-19 on the operations and ils financial resou[￿s. the Institute will have suffiuent funds to meet is liabilities as they f811 due for that period. The Institute is reliant on its Strat￿1¢ progratnme fun(ling from BBSRC. which wa8 £6.3m in the y8ar 12020.. £5.2ml. BBSRC has confirmed continued slratègit funding of £5.2m for the year to March 2022 plus provisional funding at this level for a further year to March 2023 Subject to th& next government spending view. The Institute expects its funding for the year to March 2023 to be confirmed in late 2021 b8sed on feedb8ck from BBSRC. Like tnost researGh organisations, the Institute'5 aGtwities have been impacted by COVID-19 measures. From late March 2020 nlil Jun& 2020, the Inslilute's facilities wer8 closed to all staff and students. except for essential work and activty supporting C0VID-1￿r&lated le81ing and r8se8rch. During this period, El staff and students have been able to operate efFectively frotn home and, with facilities being re-opene(I prO9￿SSive1Y sin then, the Institute h8s be8n able 10 8UCC8ssfully maintain its search progratnmes and projects wth Tninitnal financial impact. The Institute has considered the potential financial Impact of continued restricllons for the next 12 months, Including the wlential for a further Iwk(lown. Taking into 3WOUnt experience to date, business continuity arrangement8 and Exp8nditur8 Expenditure on charitsble activities represents the full cost of the r8se8rch performed. 11 include8 th& cost of dir8Ct 8taff, consutnables and indirect costs ap￿rtIoned on the basis of use. Cost of gènerating funds represents the cost of obtaining fund8 forresearch and preparing grantapplic3tions. Governance costs represent the n8ce88ary cost of compliance with sl8tulory and constitutional requiretnenls an(1 any other c05ts whiGh are not direct ch8rilable expenLlilure. Supwrt costs have been wholty allctated lo charitabl& activity exp8nditur& based upon activity as indicated in note 4 to the financial slatetnenls. R8Stri¢ted funds Wh8re re8earch at El is funded by grant8 Wlth condition8 attached to thetn these are shown as restricted. Capi131 gran15 received and receivable together with other restricted funds received and rec81vable and used lo purch8$8 tangible asse18 are included within reslricte(I funds. 19

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS ACCOUNTING POLICIES ICONTINUEDI Prov181ons A re81ricled fixed 8sse18 r888N8 h88 b88n eslabli8h8d A provision is r￿gniSed in Ihefinancial Statements wher& IhÈre P￿senting the net ￿0k value of fixed assets purchased from is a legal or constructive obligation to transfer economic benefil capital grants. The reserve is shown a5 restricted due lo to a third paty. continuing conditions In ¢onn8clion with th8 Capital grants and staff and PÈnsion$ assets purchased. El staff that joined before 1 October 2011 were employed by Unrestricted funds BBSRC up lo 1 October 2017. when they transferred These include any other grants which do not h8ve speafic &mployment to the In8tilule und8rTUPE. conditions attached to them. Transfèrred employees retain their m&mbÈtship of the Research A fixed assets resepie has been estsblished within Un￿St￿¢ted Councils Pension Scheme IRCPSI, where 8pplicable. with El reserves representing th8 nel bwk value of fixed a888ls funded becoming an admitted &mploy8r in the 8¢h&me. Th& RCPS is a from unrestricted reserves. defined benefit scheme funded from annual granl-in-aid on a Unrestricted reserves that have bpen designated by the Board pay-8s-you-go basis. The RCPS Pension Scheme is 8 mulli- for specific purposes are shown in separate designated &mploy&r sch8m& and El is unable to id&ntify 118 share of the re88Nes. Al March 2021. £6.9m12020.' £5.6ml of unre81ri¢ted un(lertying assets and liabilities. El therefore accounts for the reserves have been designated in relation to cTrfunding for 8ch8m8 as If Il w&re 8 wholly defined conlribulion sch&me. As a institute strategic programmes. strategic r88earch projects and result. the aFnount charged to the incotne and expenditu future capital investrnènt. ccount represents the contributions payable to the scheme in Capital transfer5 r8sp8cl of th& accounting period. Liabilili&s for the payment of A transfer from the unrestricted lo the reslricled reserve equal lo futurebenefits are the responsibilityofthe RCPSand accordingly the d8pr8¢18lion charge for asse18 purch88&d from unr&8tri¢lèd re not included in these Financial Slaterllenls. reseTves is made as 3 capital tr3nsfer. El ha8 r8crui18d all new staff from October 2011 on 118 own l&m8 Tangible assets and depreciation and conditions, covering basic pay and allowances, conlradual Tangible asset8 are shown al c08t or walualion18ss accumulated payments, tax. Nl, and liabilities for pension contributions and depreciation. The cost of tangible assets is their purchase cost. redundancy. Such staff are eligible tojoin a defined contribution together with any inci(lenlal costs of acquisition. scheme. Depreaalion is calculated lowrite off the cost of assets. les8 any The Company erllploys some staff jointly with the University of estimated residu81 value, over their È8tlmaled useful lfv&s at th& Ea81Anglia. Staff are employ8d under El terms & conditions, but following rates.. are eligible lo join The University Superannuation Scheme Plant, machinery and 8quipn8nl- over estimated 8conomic life,. USSI. El is obliged lo pay the prevailing employer contribution Scientific equipm&nl- 5 year8 straight lin8', rale for staff In th8 USS, however It ha8 no liability for sch&me Sequencing equipment- 3 years straight line." funding deficits Accordingly, these arrangements have been 8ccoun18d for a8 d8fin8d contribution s¢h8m8. Computer equipment- 3-5 years straight line. Termlnatlon benefits The leaseholLI improvements have been depreci8ted over the shorter of Ih&ir &stimat8d 8conomi¢ life and the remaind&r of th8 Redundancy payments a￿ recognised as a liability and an lease period. expense only when the event is dernonslrably comrnitte(I to by Assets under construction are not depreciated until the asset is Èlther". a. termination of the employment of an ern￿oYe￿ or In full u8&. group of employees before the noTrnal retirement dale. or b. Intangible assets amortisation provision of termination benefits 88 a result of an offer m8de in Computer Software Lleveloprnent costs are recognised as ord&r lo encourage voluntary rèdundancy. Operating Leases Intangible fixed asse18 al cost less amortisation and any Rentals payable under operating leases are charged to the provision for impairtnenl. Amortisation is calcu13te(I lo write off the cost or valuation of Sla18ment of Finanual A¢livilie8 on a straight lin& ba818 over the lease terrn. assets. less the estimated residu81 value. over their eslimaled useful economic lives as follows". Foreign Currency transartions Computer Software- 310 5 ye3rs slraight-line. The reporting and functional currency 18 pound8 sterling. Assets under construction are not 8mortised until the asset is in Transactions in foreign CUTrencies are ￿corded at the rate of exchange ruling 3t the date of the trans3Ction. Assets 8nLI liabilities denominaleLI in foreign currencies are translated at year end exchange rates. Ml gains and losses are taken lo the stslement of financial activities in the year to which they relate. Flnan¢l81 Instrument8 D8btors Financial assets and financial liabilities are ￿C(￿jnised upon Debtors are non-intere5t bearing an(1 are slate(l at their norninal becorning a party to the contractual provisions of the instrurnenl. value. as reduced by appropri8te allowances for estimated The group only enter8 into E>asic financial instrumenltran88ctions Irrecoverable amounts. that fftsult In financial a88&ts and Iiabilitl8$ Ilke trade and other Trade creditors accounts receivable and payable. Trade creditors are non-interesl bearing and are slated at their nominal value. Stocks Stwks are slated 3t the lower of cost 3nd net realisable value. Provision is made, where n8cess8ry, forslow moving or obsolete stock. 20

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 2. ANALYSIS OF INCOMING RESOURCES Total Research 2021 acbmties Èooo Cmher actiNities Total 2020 £000 actimties actimties £000 Grant income BBSRC (Iher gorTh￿nI deparbwts Eur(yean Lknion ikniwsities Cmher charities (Jher grants 8,466 72 24 246 396 214 7.979 42 7.979 72 24 246 396 214 90 569 113 110 Total rant inco 9,418 8.￿3 Capftal Wants BBsr C4ital e￿ndIture 1,192 1.192 2,718 171B Total ca ital rants Tr￿lthy Inco Earlham Enterprises Ltd Rentsl income 409 26 358 358 80 26 Total tradi 435 43$ 438 Inv88tnw)t Incc Interest reCei￿ble on cash ￿e￿￿tS 127 127 Total Investmnt Income 127 127 Other irKorne (Mher incorr 43 422 422 Total other In¢r) 43 422 422 Total incorrAn resr￿rCes El's activities consist princip8lly of scientific research in the United Kingdom. Grant income of £9,418k12020.. £8.903kl. £9,032k12020".£8.296kl is restriGled general funds. £386k (2020.. £607kl is unrestricted funds. Capital grants of £1,192k12020." £2,718kl, £201k12020'. £42kl18 restrlcted gen&ral fund8 and £991k12020". £2,676kl Is restricted capital funds In both periods all trading. investment and other income is unrestrict￿. 21

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 3. ANALYSIS OF RESOURCES EXPENDED Expenditu￿ on charita￿e activities and governance costs have been analysed below. Tot 2021 nd￿Ure on charttable act￿ttle5 2020 £OOD te Dir¥1 Charitstle ewdityre.. Staff cos Direct costs D8preciabon ()Mr￿n¢ co$ Supwrl ¢ost8 4.Y)1 3,251 4,470 4,180 3,609 1.396 Total e nditure Total 2021 £NJo To&1 2020 Ana i¥of n•n¢o ¢O¥t$ staff costs Tra1 costs othèr ¢0 93 Total vwnanco Costs 95 Included within 8xp8ndilur8 Is r8slrict8d general expenditure of £8,718k12020.. £8,463kl, and restricted capital expenditure Id&ptsciationl of £3,064k12020". £3,809kl. Al othèr Èxpenditur& is unrestricted. 4. ALLOCATION OF SUPPORT COSTS ChJitsW Attiiibèg Td ZQ21 £0 Charitrbl Actiirytieg Poising Funds £wo Totrl 2WO £wo Basis of JthabCAI Funds £0 I￿Ing Se￿ICe$. Finance Contracts. 492 213 Y8 130 98 492 328 Y8 130 98 318 Actimty 328 127 19 P£S￿ree$ Snd Stsff Welfarè. (knr 5UPPOrtSer￿ees 127 Aebmty Ael￿ty 57 Total su costs 179 1,281 1.396 Support costs arè allocated based on their nature. include8 8&rvi¢e8 supplied by NBI Partn&rship ￿MIl6d{S￿8 not8 231. 5. TAXATION El 18 consid&red to pass the le8ts sel out in Paragraph 1 Sch8dule 8 Finance Act 2010 and Ih8r8fore rt me&ts the definition of a charitable company for UK Corporation tax purposes Accordingly. the Charity is potenlialty exetnpl from taxation in respect of incorlle or capit81 gains received within categories covered by Chapter 3 Part 11 Corporation Tax Act 2010 or Section 256 of the Taxation of Chargeable Gains Act 1992, to the extent that such income or gains are applied exclusively lo charitable purposes. The Ir3ding activities of ils subsidiary. Earlham Enterprise Limited. are subject lo c£Ypwation tax. however profits are gifted to the charitabl8 company resulting in £nil12020.' £nill tax payable. Thère Is no provision for def&rr8d lax on fair value adiustm8nls b8caus8 any charyeable gains are applied to charitable objectwes so no tax liability arises. 22

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 6. OPERATING SURPLUS Operating surplus is stated after tharging". Total 2021 £NJo Total 2020 AuditseTNices". Fees for the auditof the charitsLle company and con￿l￿ated financial st8tenEnts Fees for audltol the chariL4￿ company's S￿￿diSrY pufsu8nit01￿lslation N￿-￿v￿lI spr¥icps. Clher lees payaLI8 to Lh& auditorsof th8 charitaLle c(ryany Deprecistion Loss on di¥wl Df langiye as C¥eratng lease renta￿ I￿nd and bu1￿1￿￿} Hire of thntand equipment LO￿<S￿nI on foreign eyLhange tran￿al0Ths 12 12 101 10 7. RESULTS OF TRADING ACTIVITIES OF SUBSIDIARY Total 2021 £wo Total 2020 Earlham Enter rlges Uned Profft and loss account Tumcwer Costol Gros¥ rxofft 358 192 153 Adttinitstrati 30 rafft and rofft on ord acth11t￿5 before taxatlon 255 In addition to the above, £135.50312020.. £218.3821 in Gift Aid was paid lo the to the charitsble cotnpany in the year. 8. REMUNERATION OF MEMBERS OF THE BOARD OF TRUSTEES El has been given approval by the Charities Comrnission to remunerate trustee5 where the Board wn5iders that payrTTrenl is necessary to 8ttr8Ct trust8es with sp8cialisl skills and &xperi&nce. The power to remunerate Iruslees 18 Included in El'8 Artic1&8 of Association. Six tnetnbers of the Board of Trustees ￿CeNed remuneration frorn the group duriTrg the yearfortheir duties as a Trustee12020". inel. Totsl trustee rernuneralion in the year was £29,OW12020.. £30.0001. Detsils of the remuneration pai(1 during the year is as follow8.. Total 2021 £No Total 2020 Nan ofTruSts0 Professor P8ler Pknland Professor Ihomas Flchards Professor Robbie Waugh Prolessjr Dan Janetlhornknn $ kndrea Finegan Dr Alasdair M8cn8b Profewr Edvtsrd Ltsui$ Profe￿[ V8ronica Van Hsyningen PrOfe&￿r Jean Be Total 29 Attendance expenses were incurred by zero12020 31 TTUStees whilst carrying out Iheirduties amounted to £nil12020." £8771 during th8 year. 23

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 9. EMPLOYEE INFORMATION The average monthly number of persons employed by ordeployed to the group. analysed by category. was as follows". Grou and com an 2021 Numbor 2020 Nu￿ber Sciendfic Officfr rnan Totsl 91 17 108 87 21 em8ntand ser¥icgS The aggregate payroll costs of these persons were.. 2020 £000 Wages and salaries RedU￿￿cY Gl)5ts Social security ¢os¢¥ (Iher ension Costs Tota 4,117 4,072 404 570 5,050 5,157 As r8quir8d by Charit8s SORP an analysis ha8 been provid8d below of the number of staff who fall within emoluments bands frotn £60.000 upwards. Grou and ¢har#abk com 2021 Number NuNer £60,0￿- £69,￿9 £70.OW- £79.9 t1M,NO- £109, £1￿￿o-£169 To￿1 10 Th& numb&rofstaff with emoluments greaterthan £60.000 whowère members oftt)e Research Councils. Pension Schemes was 412020.. 21. The number of stsff with ernoluments greater than £60.000 who were rnernbers of a cornpany stakeholder pension Scheme was 512020.. 31. St8ff Ihatjoined priorto 1 October 2011 We￿ employe(I by BBSRC up lo 1 October 2017. when these employees transferred 8mploym8nt lo the Institu18 under TUPE. Tran8f8rr8d &mploy88s retain their membership of th& Research Councils P8nsion Scheme. where applicable. with El bpcotning an adtnitted etnployer in the scheme. stafF Ihatjoin8d after 1 October 2011 are employed undér El terms & conditions. The key management personnel of the charitable company 8re considered lo be the members of the executive team.. the In$lilute Dirèctor. Dlreclor of Op&ralions, Head of Genomics Pipelin&, Head of Plant Genomic8, Head of Re8&arch Faculty Office and Head of Rese8rch e-infraslruclure. The key man8gemenl personnel of the group comprise those of the charity and the key manag8ment P8rsonn81 ofthe wholly own8d subsidiar18s, Earlham Ent8rprise8 Ltd I'EEL"). The k&y manag8ment personnel of EEL is considered to be the Institute Director IEII and the Director of Operations IEII. No costs We￿ recharged in respect of this. The tol81 employee benefits of the key management personnel of the charity and group were £673.21412020.. £793,268). 24

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 10. INTEREST RECEIVABLE AND SIMILAR INCOME Total 2021 £(KJo Total 2020 Inkfe# On h)ans Totsl 11. TANGIBLE ASSETS PLqnL r(Éehlnery Leasehold under irnprovemnts equiprnenl ¢￿sIr￿ctI( Grou and thar*Abk com an Total £000 £0 £￿0 At 1 April 2020 Transfers Additons 25.641 971 579 1,164 127 1,022 169 1,728 169 31 March 2021 At 1 April 2020 Charg8 for the year 8L At 31 March 2021 5.492 205 19.0 2.847 24,4 3,052 Net bookvalue at 31 March 2021 Nel t￿k value al 31 March 2020 All of the charitable company a8sels at 31 March 2021 8re used for direct charitable purpos88. A88&ts under con81ru¢lion repre8&nl capital il&ms which ar8 not y81 in full economic use. 12. INTANGIBLE ASSETS Grou Total £Mo Al 1 April 2020 Addl￿On5 31 March 2021 177 177 177 177 AccumulatedDeweclaUon At 1 April 2020 Char eforthe ear 31 March 2021 12 177 12 177 Nat book valutr at 31 March 2021 Nel ￿M70k al 31 March %120 12 12 25

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 12. INTANGIBLE ASSETS ICONTINUEDI Stsfmèfe de￿[￿nI Charita￿0 Total At 1 Awil 2020 Addl￿ons 31 March 2021 147 147 147 147 At 1 April 2020 Cha elorthe At 31 Kgr¢h 2021 125 12 147 135 12 147 ear Net bookvalue at 31 March 2021 N&1 ￿0k value al 31 Mar¢h 2020 12 12 The intsngible asset relates to internally generated research s?fr￿are. 13. FIXED ASSET INVESTMENTS Subsldlary Th&charitable company's Inv&8tm&nt In its subsidiary und&rtaking al costamountsto £1. Th&following Is the operating 8ubsidiary undertaking in which the charitsble ￿rnpanY has an inlere5t'. Country of istration Cl¥¥$ and of shares hpkl Subsldk Undertthn Prkncl acthf E8rlh8m Enterprises Engl8nd c￿tr8ct research 100% ordin8ry sh8res Earfham Enterpris&s Limited (company r8gislralion number 068121131 reg18t&red addre88 18 Norwich R8$ear¢h Park, Norwich, Norfolk. NR4 7UZ. Th8 charitable Company has ¢ommitt8d to provide financial support to Earfham Enlerpri88s Limi18d I"EEL"I, and not d8mand repayment of amounts due to it. in order to enable EEL lo meet its li3bilities as they fall due- bul only to the extent that money 18 not otherwise 8vailable to the company to me81 such 118biliti8s- for a p8riod of al 18a8t 12 month8 from the signing of the financial statements of the EEL forthe year ended 31 March 2021. EEL is a tnetnber of Anglia Innovation Partnership LLP. which is reS￿nSibleforIhe managementand developmentofthe Notwich Research Park land and for the furtherance of the NRP Enterprise Vision. El is entitled lo re￿1ve a share of certain profits gen8ral8d by Anglia Innovation Partnership LLP. how&v&r il ha8 no liability for 10888s or in the event of Insolv8ncy. Anglia Innovation Partnership LLP has not yet generated any profits. El has a 25% interest in NBI Partnership Limited I"NBIP"I. NBIP supplies sUPPQrt and adtninistrative swices to El and the other Norwich Institutes (John Innes Cenlre. auadram Institute Bioscience and The Sainsbury Laboraloryl on a nol-for-profil basis. NBIP fully recharges its costs lo th& four re8&8rch organisations and accordingly it g8neral88 no profil or loss. 14. STOCK Total 2021 £No Tolal 2020 Grou and ¢har*abk com an Rawmaterlg& and consuNÈb￿s Total 163 163 26

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 15. DEBTORS Group 2021 (￿p Corrpany C(wny 2020 2020 £000 bte Grants rec&vable' from gO￿￿T￿nt ￿￿leS from (Aher FA)ufGes Trade dbtor$ Amunts ovEd by sutHdiary undertakings knunts i¥vEd by other related parties Cmher debtors Pre nEnts aTKJ &C[L￿ inCOTT Total arTh)unts fallin due within one 407 243 314 176 252 470 407 176 252 70 227 178 23 171 73 178 73 882 164 The above amounts fall due within one year. Grants receivabl8 from government bcK1ies includes £75.602 in relation lo capitsl funding rec8ivabl8 from BBSRC12020.. £127,223). 16. CASH AT BANK AND IN HAND Group 2021 £000 (>oup 20 £0 Conyany 2021 £wo Conwany 2020 C£sh 81 bÈnk Total 14 945 329 329 14 923 17. CREDITORS: AMOUNTS FALLING DUE WITHIN ONE YEAR Group 2021 £000 (￿p Conw•ny Con)sny 2020 2020 tooo te Grants rec&v6din advance." from gO￿[￿r￿￿t ￿leS from (ther sour¢as OWEd ts) otrer re￿ted parles Trade creditors Cmher creditors Ta¥aton and social S8Gurity Accruals and deferr￿ Inco￿ Total arwunts fallin due %ithin one 1,241 71 1,049 376 307 1,216 939 106 1,241 387 307 1,216 23 190 857 1,241 105 1,241 120 106 ar 517 4.954 18. RECONCILIATION OF MOVEMENT IN GRANTS RECEIVABLE Total 2021 Tot 2020 £000 Grou Note (>8nts racelvabla fy8nts re¢eld In 8dv8nce Not rants r￿al¥•b￿ at tho ond ofth8 15 650 428 786 granis Irecei¥fd in advanG81 I recei¥fbb at beginning of year Sni ￿nIeS r¢ei¥*d during yoar fy8nl n￿n rek¥sed 10 SOFA durin Not ront¥ r¢¢81vab￿ at tho ènd of th8 o•r I 18841 18,9341 18.4&11 786 27

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 19. ANALYSIS OF NET ASSETS BETWEEN FUNDS Fi assets £0 current Total 2021 Group Un¢siri¢tecl.' Fiy4d ?ssgt r88fP Deggnated [￿[ C￿eral reserve 6,877 4,1( 4877 4105 Fi)pd ?sset r88ep Deggnated reset¥es Geral reser¥e 428 Total net assets 271 Charita￿0 wrnpany UnreslriGled.' Fi￿d assetreseNe De%gnated reseDEs General reser 804 6,877 3,￿6 877 1838 ReslTIGted.. Pl￿d assetrese Deggn8led reseDES General re$8TrP 10 8,586 428 Total tw È8s8ts 014 Fix assets Èo(K) current Total Group FIyEd asset reserv 0&ggnated r8sep eral reserve 951 951 15n 4530 5,572 ResiTi¢ifd." Fixd ?$8et reseTr Deggnaled reser¥es eral reserve 9.904 1,651 381 1,651 381 Total n2t assets ChritaW8 ¢ornpany UywaslriGled.. Fixd assetreset¥e Deggnated reseDES (knefal ￿Ser¥* 941 &572 ResiTi¢ifd." Fiy4d ?ssgt r88fP Deggn81ed resep￿S c￿er&I reserbÈ 9.914 9,914 1,651 381 Total n2t assets Th8 unrestricted fixed asset re88rve represents the n8t book value of fixed a888ts purchased from unre81ricted funds. T nrestricted designated r&servÈ rèlates to funds designated by the Board for use in relation lo co-funding for institute sttslegic prowJr8mmes. slr8tegic projects and future capital inveslrnent. The restricted fixed asset reserve relates lo the nel ￿0k value of fixed assets purchas￿ frotn upilal grants The restricted designated reserve relates lo advance c8pitsI and project funding received from BBSRC. The reslricled general reserve relates to advanc& strategic funding r8c8ived from BBSRC. 28

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 20. ANALYSIS OF FUNDS MOVEMENTS Unrestricted as8ets Unrestricted Unr8striGted Reskncted reserve desi nated enera d nated £000 Restricted Rericled Total 2021 resen Èo(K) Group At l April 2020 (efadng Surplugldefieitl ftt year C?pitsl tr?nsfers Unrestricted general capital ewendthjre Unre5tricled designated transfer REStrleted de51gnated transfer er transfers At 31 htsr¢h 2021 951 4,￿0 1,651 9,9 12,0731 381 515 21989 11,3601 12521 105 189 T13 11581 16321 632 468 6.871 468 428 861 Chartta￿e ¢oMpany At l April 2020 (er#￿ng Surplugldefieill for the year C?pitsl transfers Unrestricted general capital ewendthjre Unrestricted designated transfer Restricted designatsd transfer er transfers At 31 ktsr¢h 2021 4,392 71 1,651 9,914 12.0731 381 515 21851 11,4871 12421 105 169 T13 11581 16321 632 468 6.871 468 428 3.￿8 861 Unrestricted y£d 8ssets Unfèstritted Unfèstritted Resthcted reserw desi natsd eneral des nated £000 Rethcted Rerlcted Total 2020 r&set Group At 1 Pprll 2019 (*eraung 5urpluslldeficill the year Capitsi transfers Unrestricted general capital ewenditure Unrestricted designated transfer Rèstrieted dè51gnated tr8nsfer Other transfe 31 March 2020 1.162 6.299 4.517 14381 600 389 19321 474 11,4951 14741 263 704 11581 11041 95 11,1551 63 125 5.572 4.￿0 9.904 Charita￿e Company At 1 Ppril 2019 er3￿ng Surplugldeficill for the year C3pitrl tr?nslfrs Unrestricted general Gapital ewenditure Unre5tricled designated transfer Rpstricted designated tr8nsfer Other transfers At 31 March 2020 1,140 6.￿9 4.327 13861 600 11,509 I￿2) 389 24,264 11,4131 14WI 263 7LM 11581 11041 I1.1￿) e3 125 381 5,572 4.392 851 Capital transfer8 r81ale to fund movem8n18 in conn8ction with fixed a8sets and depreciation., Ènsuring ass818 are 8ppropriat8ly ected in separate reserves. UnrÈstricled general rapilal expenditure relates to fixed assèt purchases funded from th& unrestr￿ed designated resetve. Th8 Unrestricted designated transfer represents movements in unr88tricted funding for institute strategic programmes, 8trat8gic expenditure and futu￿ capital investmènt. Th8 Restricted designated transfer r8pr8s8nts mov&m8nts in restricted BBSRC funding for capital, projects and 8tr8t8gic grants. Othertr3nsfers relateto the nel surplus on restricted research grants. which ha5 beentransferred lo Un￿strICted general reseNes upon performanc& of th8 grant conditions. 29

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 21. COMMITMENTS Total 2021 £LKJO Total 2020 Grou and ¢h8r#¥b￿ ¢om an C£pltsl althe end of the fin8nclgl ye8r for*lth no W￿ls1oTh ha$ been mde. Contrscidd 892 702 Total 2021 £No Total 2020 Grou and ¢harknbk com an Amunts due under other operating1è$9e5 for land and bulklng& Lknder year Bets¥pen th)e five ye£rs (hrs 100 400 1476 Amunts due under olher operating l&ases for plant and TTHchinery. iknder one year BeNVeen One arhd flve yB8rs r S ars 22. PENSION SCHEMES All staff employed by El on 30 September 2011 became BBSRC employees on 15 March 2012 and were deployed back lo the Inslilut8 und&r ¢ondition8 set out in th& Deploym&nl Agr88m&nt Ilhe "D8ployed Employe881. On 1 October 2017, D8ploy8d Employees transferred etnploytnenl to the Institute under TUPE. Deployed Employ&es relain their membetship of the Resèarch Councils PÈnsion Schème IRCPSI, wh&re applicable, with El becoming an adrnitte(l employer in the scherne. The RCPS is a defined benefit scheme funde(I from annu31 gr3nl-in-aid on a pay-as-you-go b88i8. The RCPS Pension Sch&me is a mulli-8mployer scheme and El is unable to identify its share of the underfying as8&ts and liabilities. El the￿fore accounts for the scheme as if il were a wholly defined contribution schÈme. As result. Ihe amount charged lo the incorne and expenditure account represents the contributions pay3ble to the scheme in respe of the accounting p8riod. Liabilities for the payment of future ben8fit8 are th8 re8pon8ibility of the RCPS and accordingly are not included in these Financial Statements. The employer contribution rate during the yearwas 26'h12020.. 26%). El 8mploy8e8 thalioined after 30 S&plember 2011 are eligible loiryn a defin8d contribution schem8. Th& Company &mploy8 some staff jointly with the Univ8r8ity of East Anglia. Staff are employed under El terms & condition8, bul a￿ Èligible lojoin Thè University Superannuation Scheme IUSSI. El is obliged lo pay the prevailing èmployer contribution rate for staff in the USS. however il has no liability for scheme funding deficits. Accordingly. these arrangement5 have been accounted for as d8fined contribut￿n sch8m8. The tol81 pension charge for the year was £602.27812020.. £570.1301, with outstsnding conthbutions al the yearnd of £40,110 12020.. £34,191). 30

Earlham Instltute | Annual Report and Accounts | March 2021 NOTES TO THE ACCOUNTS 23. RELATED PARTY TRANSACTIONS Biotechnology and Biological Science Research Council I'BBSRC'I Th& charitable company Is stra18gi¢ally ftIr￿ed by BBSRC along with seven other Inslilut8s and BBSRC 18 one of the memb&rs ofthe charitable company. BBSRC is part of UK Research and Innovation IUKRII. an organisation that brings together the UK'S seven research councils. Innovate UK 8nd Research Eng18nd. During the year BBSRC charged El £nil12020 £3.9831 for subscription charges and Olher costs. As at 31 March 2021, El owed BBSRC £52,39912020.. £nill. BBSRC provided £6.707.000 12020.. £7.979.0001 of funding for ￿Se￿rCh and in gddition it provided £1.778.000 12020.. £2,676,000) of funding for capital purchases in the year 8nded 31 March 2021. As at 31 March 2021, BBSRC owed El £78,772 12020". £176.2811, ofwhich £75,60212020". £127,223) was for capital purchases. NBI Partnershlp Llmlted I'NBIP'I El is one of four members and guarantors of NBIP. a company lirlliteLI by guarantee. El has provided short-terrll loans lo NBIP to Ènabl& NBIP to manage its cash re4uiremÈnts. Al 31 March 2021, El had a loan balance Nwth NBIP of £100,000 12020". £105.0001. During the yÈar, El was charged £1,312,698 12020". £1,353,299) for 8Èrvices under a c081 sharing agre&ment. As at 31 March 2021. El owed NBIP £159.81212020.. £122.4091 and NBIP owed El £2.00012020. £2.1001. University of East Anglia I'UEA'I UEA 18 a m8mb8r of the charitable company. During the year, El invoiced UEA £82,268 12020.. £79.0651 for servic88. UEA invoiced El £171,57012020". £73.9021 for miscellaneous costs and £473,46812020". £477.0961 for staff costs. A8 at 31 March 2021, UEA ow8d El £68,55512020." £71,201) and El ow8d UEA £128,18812020'. £48,812). Anglia Innovation Partnership LLP I'AIP LLP"I El is a mernber of Angli3 Innovation Partnership LLP through ils 100% subsidiary. EEL. Angli3 Innovation Partnership LLP is responsible for the management and development of the Norwich Research Park INRPI e8lale and for th8 furtherance of the NRP Enterprise Vision. During the year. El received services totalling £5,35712020. £4201, and was charged £19,177 12020". £19.597 for estste costs. As 3131 March 2021. El owed AIP LLP £19,17712020.. £19.1771. El invoiced AIP LLP for servi*s totslling £nil12020.. £3751. As at 31 March 2021 AIP LLP i)wed El £nil12020.. £nill. Earlham Enterprlse8 Ltd E8rfh8m Enterprise8 Ltd 18 the wholly owned trading sub8idiary of El. EEL undertake8 contract r8se8rch. re88arch serwices and consultancy. During the year, El invoiced EEL for s8rvic8S and other costs lotslling £233,49612020.. £279,6411. In addition. EEL mad& a gitt aid paytnent to El of £135,57312020." £218,382). As at 31 March 2021. EEL owed El £85.10512020." £226.5311. 24. ULTIMATE PARENT UNDERTAKING AND CONTROLLING PARTY The Trustees consider that there is no ullirnate parent undertaking and controlling party. El is the parent undertaking of the smallest and18rgesl group of undertakings lo consolid8te these financi81 statements. 31

Earlham In8tltut8 | Annual Report and Accounts | March 2021 REFERENCE AND ADMINISTRATIVE DETAILS Directors and Trustees Professor Darne Janet Thornton Dr Alasdair Macnab Professor Peter Holland Professor Thomas Richard5 Ms Amanda Tagg Mrs Andrea Finegan Professor Jean Beggs Professor Edward Ltsuis Professor Philip Gilmartin Chair- Board of Trustees Chair- Audit Committee Chair- Remuneration Cornrnittee Key Management Personn•l Professor Neil Hall Mrs Sarah Cossey Dr Karim Gharbi Professor Ant Hall Dr Christine Fosker Dr Rob Davey Institute Director Director of Operations Head ol Genomics Pipeline Head ol Plant Genomics H88d of R8S88rch Faculty Office Head ol Research e-infrastructure Registered charity number 1136213 Reglstered company number 06855533 Registered office and principal office of the charity Norwich Research Park Colney Norwich NR4 7UZ Independent auditor Larking Gowen LLP Chartered Accountants and Statutory Auditors King Street House 15 Upper King Street Norwich NR3 1RB Banker Barclays Bank PIC Red Lion Street Norwich NR1 3QH Solicitors Taylor Vinters LLP Merlin Plac8 Milton Road Cambridge C84 ODP Birketts Kingfisher Housg 1 Gilders Way Off Barrack Street Notwich NR3 1UB 32