Christopher'8 Smile coz kids 8 e+ concer too Trustees, Report th for the year ending 30 April 2022 Our vision is for every child diagnosed with childhood cancer to not only survive, but to reach adulthood enjoying a good quality of life. Charity Registration Number I129￿6 Trustees Mr Kevin Capel Mrs Karen Capel Mr Denis Conroy Mrs Rosemary Conroy Prlncipal Office 10 Ivy Drive Li8htwater Surrey GU18 5YZ Bankers HSBC plc 29 High Street Camberlev Surrev GU15 3RE Website www.christo herssmile.o Principal email address info christo herssmile.o -uk Trustees Report for year ending 30 April 2022 Introduction to Christopherfs Smile In October 2006, Christopher Capel then aged 4 was diagnosed with Medulloblastoma. an aggressNe paediatric brain tumour. Following 21 months battling the disease Christopher lost his fi8ht for life in June 2(K18. nine day5 before his sixth birthday. Christopher was the only child of Karen and Kevin Capel. Following their tragic loss, Karen and Kevin Capel wanted to help chIld￿n with can￿r in the future by funding research into new treatsnents for childhood Can￿r. Background to Christopherfs Smile Christopherfs Smile started in October 2CM)8 and was registered as a charity by the Charity Commission by a Declaration of Trust Deed dated 10 May 2CM)9. The charity raises funding exclusively for paediatric cancer research with a bias towards the introdurtion of tar8eted therapies to replace the existing cytotoxic chemotherapy and radio therapy treatments currently used. Support for the charity continues to grow and the chartty is well known In North West Surrey. Christopherfs Smile has a fimi principle that every penny of a donation should be used for the cause for which it was given. The charity has continued with this principle for the financial year 2021 2022. Alms and Objectives After Christopherfs death, we wanted to make a difference for children with cancer in the future. Although there are many charities that raise fund5 for different aspects of childhood cancer we saw the only way of breaking this terrible cycle was to fund research. We had seen first hand the efficacy and side effects of current treatments both in Christopher and the other children in the Royal Marsden's Children's Oncology ward. We learned that if a child survlves, thelr Ilfe and that of their family is never the same again. It was these memories that led to our charity's vision: "Our vision is that every child diagnosed with childhood cancer wlll not only survfve but reach adulthood enjoying a good quality of life." This vlsion has been tran￿ated into our charivs objects as. l. Provide funding to non profit making ￿searCh organisations that further research into paediatric cancers. 2. Raise awareness of the needs of non profft making research organisations that further research into paediatric cancers 3. Raise awareness in the general population of the need for fundin8 the research into paediatric Can￿r$ Christopherfs Smile is a target based organisation. We made the decision to set a fundraising target in order for our supporters to know what their money is to be spent on. We also believe that a charit￿5 funds should be spent or allocated the earliest opportunty. Christopherfs Smile continues to hold the following set of values. When we stsrted the charity we decided to adhere to a set of principles which we believed in and which our donors would respect. > Every penny of every donation would be used forthe cause forwhich it was 8Nen. > Costs would kept to a minimum and do as much ourselves as we can. > Where we need to buy in products or expertise we would control costs vigorously. Every donor or supporter should be shown exactly where their donation has been spent. > Build a relationship with donors and value every donatlon no matter how Small. > Ensure that funds are spent in the best way possible to get maximum benefft from them. We set these objectives for our first year and our aim is that they will remaln in place while Christophefs Smile is still needed to rdise funds for childhood cancer research. Paedlatric Oncology Activities and Influential Factors May 2021- Aprll 2022 Thls year has been the second year where Christopherfs Smile's actNtties have been influenced greatly by the Covid 19 pandemic. As the UK slowly exits from Covid 19 re5triction5, the pandemic is likely to leave a legacy in a number of areas of fundraisin8 activity. Notabty these are.. A huge reductlon In the use of cash and a greater transition to spendin8 usin8 cards or ca5hle5S Systems such as Apple Pay, Goo8le Pay and PayPal. Face to face fundraising actNities have not existed during the pandemic and wlll take time to resume due to people's relurtance to mix freely. Working from home has become an accepted practice and this has caused an almost elimination of socialisin8 both inside and outside of the workplace and any subsequent charity support actNities. A reappraisal of people's finances durlng the pandemic and the prloritisation of familv spending resulting in fewer charity donations especially as charities became less visible durin8 the pandemlc perlod. The factors above have meant a huge decline in income for Christopherfs Smile. This decline in income has meant a slower 8rowth in our reserves. Our 'Liquid Biopsies for Children. project finished at the end of December 2021 and while this project has resulted in more evidence for Liquid Biopsies to be used in NHS Standard of Care. our high level objective of Includlng braln tumours In thi5 work wa5 not successful. This was due to a number of factors, the chief fattor being the availability of cerebral spinal fluid for genomlc analysls. Thls Issue must be corrected before we as a charity will fund projects to gain enough eviden￿ for Liquid Biopsies to be used in NHS Standard of ca￿ for children with brain tumours. Fundln8 fu￿re Projerts The trustees of Christopherfs Srnile take their responsibilities for the spending of donors. funding very seriously. We will not fund a project just to say we have a project in progress regardless of the benefits that the project initiators claim. The trustees are still commttted to the genomic analysis of brain tumour DNA in order to assist in the furtherance of treatments for paediatric brain tumours. Paediatric brain tumours kill more children than any other type of paediatric cancer and it 15 for thi5 reason we a￿ prepared to fund future projects but only when the procedural and logistical issues that have severely retarded progress in obtaining cerebral spinal fluid have been resolved. The trustees firmly support the view that the analysis of ctDNA from cerebral spinal fluid will be a revolution for some types of brain tumour that are currently inoperable. It is completely ironic that the genomic analysis technology exists as it is no different to that in place for other solid tumour liquid biopsies. The difficulties are entirety Pr(￿edural and logistical and we continue to talk to relevant parties to get these issues resofved. When this has been achieved. we will be prepared to fund a project but not before. Income for year ending 30 April 2022 £16884 Cost Offset £25780 £2187 Incomefrom events Donations Sponsorship Grants GiftAid interes¢ qronts spedftolfylorcost offset £26 Running Costs £48 Card trnnsaction fees £134 Cost of events £16858 Net amount after costs £25732 £2053 Profitfrom events Net Donatlons Sponsorshlp Grnnts GIftAld £10980 Increase in restricted and designated fvnds note £33663 Availablefor researchfvnding Note: _ £3(KJO vms transferred from cost offset to research ftjnding and £2878 was released from amounts paid by solicitors. Please see the Notes to the accounts for full detsil. Our Achievements Fundraising In the year May 2021 to April 2022 Christopherfs Srnile has directly raised funding only through direct donations: Dlrect donations Donations were received in a number of ways: > Direct donations either in person or by post > Donations from organisations or compan￿$ > Support from clubs and associations. Grants Made Liquid 8iopsies for Children Start date I"January 2019. Maximum Amount Committed £240,844 over 2 years. This grant will fund consumables for liquid biopsy tests. Manpower for the prolect is provided through a BRC funded ICR PhD student. It should be noted that the maximum amount committed will be under constant review and all opportunities for economies will be explored. No compromise on project quality will be made to reduce costs. Thls projett was delayed for I year during the Covld 19 pandemic whlch ha5 resulted in the agreed project spend to be spread over a 3 year period. It must be noted that Christopherfs Smile has not been charged with any additional costs for the project as our fundin8 cOVe￿d DNA sequencin8 Costs only and these dld not change over the Ilfe cycle of the project. Financial review Highlights Total receipts were £44.851 with un￿$tr1rted net receipts of £27,967 Restrirted funds mainly comprise donations from the trustees. donations from solicitors wlth tlme restrictions on them moving to unrestricted and interest receivable. Donation5 from the trustees and interest re￿1vable are used to cover of the running costs of the charity. Designated funds are amounts donated to the charity for specific purposes. Amounts paid into the restricted funds ex￿e￿ costs by £16.858 this year. When added to amounts brought forward from last year this 8rves a balance of £20,597. This balance comprises £16,931 from solicitors and E3.666 other restricted income. Restricted costs have been running at around £600 in previou5 years although this year they were onty £26 due to reduction in costs. It has therefore been declded to transfer £3.CKX) from restricted funds into unrestritted fijnds. An additional amount of £2,878 has also been transferred to unrestricted from balan￿S received from solicitors leaving a balance of £14,719 included in restricted funds and this is fully described in the notes to the accounts. All clothin8 Costs are induded in restricted funds as most of the clothing bought is gsven to people who are competing in sponsored events to raise money for the charity. Any ￿leS are made are at cost and the receipts are added to the restricted funds budget. Total Funds Available for Charltable Glvln8 Total funds available in unrestricted funds as at 30 April were £477.742. From these funds £48,420 has already been committed to the ICR. Gift Ald Gift Aid on sponsorship and donations totalled £2.298 Reserves policy The reserves policy of Chrlstopherfs Smlle is to maintain a balance on unrestrictive funds to cover any commitments made by the charity. As at 30 April 2022 our commitments were £48,420 the balance on the unrestricted funds at 30 April 2022 of £477,742 fully covered this commitment. Liquid Biopsles for Chfildren Our latest project is Liquid Biopsies for Chiklren Dia8nosed with Cancer. This is a next step to our funding of the development of the NGS Panel Test. A liquid blopsy Is a genetSc test of circulatlng tumour DNA in a chlld's blood or