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2025-03-31-accounts

ALZHEIMER'S BRAIN BANK UK

Company No: 05762960 Charity No: 1114578

ANNUAL REPORT and FINANCIAL STATEMENTS

FOR THE YEAR ENDED

31 MARCH 2025

ALZHEIMER'S BRAIN BANK UK

Contents

For the year ended 31 March 2025

Page
Reference and Administration Details 3
Trustees Report 4 - 7
Independent Auditor's Report 8 - 12
Statement of Financial Activities 13
Balance Sheet 14
Statement of Cash Flows 15
Notes to the Financial Statements 16 - 20

2

ALZHEIMER'S BRAIN BANK UK

Reference and Administration Details

For the year ended 31 March 2025

Address and Registered Office: Unit 3 - 4, 3 Riverside Granta Park Cambridge CB21 6AD

Trustees and Directors: Mr Alastair Balls Dr Simon Ridley Prof Gordon Wilcock Dr Emmanuelle Astoul Ms Jacqueline Dobson Mr Giles Dennison (appointed 14 June 2024)

Secretary: Mr Philip Dunn

Principal Bankers: Barclays Bank plc Leicester LE87 2BB

Solicitors: Cripps LLP Number 22, Mount Ephraim Tunbridge Wells Kent TN4 8AS

Independent Auditors: Streets Audit LLP Chartered accountants & statutory auditor 3 Wellbrook Court Girton Cambridge CB3 0NA

3

ALZHEIMER'S BRAIN BANK UK

Trustees Report

For the year ended 31 March 2025

The Trustees present their annual report and financial statements for the year ended 31 March 2025 which are also prepared to meet the requirements for a directors' report and accounts for Companies Act purposes. The financial statements comply with the Charities Act 2011, the Companies Act 2006, the Memorandum and Articles of Association, and the Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).

The Trustees confirm that they have complied with the duty in Section 4 of the Charities Act 2011 referring to the guidance contained in the Charity Commission’s general guidance on public benefit when reviewing the charity's aims and objectives and in planning its future activities. In particular, the trustees consider how planned activities will contribute to the aims and objectives they have set. All members of the Board of Trustees give their time voluntarily and receive no benefits from the Charity. Any expenses reclaimed from the Charity are set out in note 8 to the accounts.

Aims and Objectives of the Charity

The principal activity of the charity is to continue to protect and promote the health of the public, in particular by establishing, promoting and maintaining brain banks of brain cell tissue for research into the causes, prevention, treatment and cure of Alzheimer's disease and associated neurodegenerative diseases and disorders, including the facilitation, development and dissemination of research into practical applications for the prevention or treatment of Alzheimer's disease and associated neuro-degenerative diseases and disorders; to advance public education (including scientific education) and awareness in matters relating to Alzheimer's disease and associated neurodegenerative diseases and disorders.

The charity meets its aims and objectives by providing grants to organisations that facilitate or undertake research.

The Sponsoring Charities of the Alzheimer's Brain Bank UK (ABBUK) are Alzheimer's Society (Charity No. 296645) and Alzheimer's Research UK (Charity No. 1077089).

Fundraising

ABBUK is fully aware of the requirements of the current Fundraising Regulations and confirm that there has been no fundraising function in the year and that no requests for donations are made either directly or through 3rd party fund raising agents or organisations.

Achievements of 2024/25 and Financial Review

The charity's results for the year show a surplus of £121,221 (2024: deficit £20,242). The scientific annual review of the Brains for Dementia Research (BDR) programme took place on 2 September 2024 and the financial recommendations for salaries for year five of BDR4 were presented at the September ABBUK meeting; scientific and financial recommendations for year five of BDR4 were presented at the November ABBUK meeting. Funding for year five of phase four of the Dementia Research (BDR4) grants has been approved by the sponsoring charities and the ABBUK Board of Trustees agreed to fund year five of BDR4 to the extent of £938,580.34, plus a further £60,000 for marketing and communications activities.

4

ALZHEIMER'S BRAIN BANK UK

Trustees Report (continued)

For the year ended 31 March 2025

Future Developments

During 2025/26, the trustees wish to continue to protect and promote the health of the public in line with the charity's aims and objectives through monitoring the activities of the institutions' awarded grants to carry out specific research activities.

Structure, Governance and Management

Alzheimer's Brain Bank UK (ABBUK) was incorporated on 30 March 2006 as a company limited by guarantee, registration No. 05762960 and registered as a charity on 6 June 2006, registration No. 1114578. ABBUK commenced its activities in April 2007 and is governed by the Memorandum and Articles of Association. The charity is a joint venture between Alzheimer's Society and Alzheimer's Research UK.

The Board of Trustees has the responsibility for the governance and strategic direction of the charity, ensuring that it delivers its key objectives. The operational processes which mainly cover the disbursement of the approved grants are managed by operational staff at the funding charities.

Board of Trustees

The company's Articles of Association provide for Trustees, who are also directors for the purposes of the Companies Act 2006, to be appointed by the members of the company on recommendation of the existing trustees, who are able to appoint new trustees to fill a casual vacancy up to the next general meeting.

The Board meets at least twice a year, to review strategic options and other matters relating to the grant making activities of the charity.

Key Management

The charity does not directly employ any staff.

The present trustees are listed on page 3. The trustees of the charity during the year were as follows:-

Mr Alastair Balls Dr Simon Ridley Prof Gordon Wilcock Dr Emmanuelle Astoul Ms Jacqueline Dobson Mr Giles Dennison (appointed 14 June 2024)

New Trustees do not get any formal induction training on appointment. However, each receive an induction pack with information about Alzheimer's Brain Bank UK activities that is compiled by an administrative officer and approved by the Board of Trustees.

5

ALZHEIMER'S BRAIN BANK UK

Trustees Report (continued)

For the year ended 31 March 2025

Risk Management and Internal Controls

The Trustees have responsibility for ensuring that the Charity maintains comprehensive risk management systems and appropriate actions are being taken to manage and mitigate risks. The Trustees have therefore undertaken an assessment of the current risks and concluded that in view of the size of the charity and that support from the major funders is available as required, the controls and procedures operated by Alzheimer's Brain Bank UK are sufficient for the organisation's needs. However, there is risk that the charity would be exposed to through association with it's funders Alzheimer's Society and Alzheimer's Research UK if their risks were not adequately mitigated. This risk is managed through assurance from the risk management processes in place for the two major funders.

Reserves and Reserves Policy

At the year end the charity held reserves of £415,974 (2024: £294,753). As the main source of income is funds from the sponsoring charities which have been agreed at levels to meet planned expenditure, the Trustees are satisfied with this reserves position. Both sponsoring charities have confirmed their commitment to this expenditure.

Grants

Grants receivable are included in the accounts when the charity is entitled to the income, there is adequate probability of receipt and the amount can be quantified with reasonable accuracy.

Research grants payable to research institutions are included in the accounts when an agreement is made to commit funds, notwithstanding that payment of the funds may be made at a later date.

Going Concern

The use of the going concern basis of accounting is considered to be appropriate because there are no material uncertainties related to events or conditions that may cast significant doubt about the ability of the company to continue as a going concern.

As part of the Trustees’ review of going concern, discussions with the funding charities are underway regarding the level of funding for the year to 31 March 2027. Draft proposals have been reviewed and the charities have confirmed their commitment to supporting ABBUK until at least that date.

The Trustees have a reasonable expectation that the charity has adequate resources to continue in operational existence for the foreseeable future. No material uncertainties in relation to the ability of the charity to continue on a going concern basis have been identified by the Trustees. Thus they continue to adopt the going concern basis of accounting in preparing the financial statements.

Statement of Trustees' responsibilities

The Trustees are responsible for preparing the Trustees' Report and the financial statements in accordance with applicable law and regulations. The Trustees are also directors for the purposes of the Companies Act 2006 and have responsibilities under that Act.

6

ALZHEIMER'S BRAIN BANK UK

Trustees Report (continued)

For the year ended 31 March 2025

Statement of Trustees' responsibilities (continued)

Company law requires the directors to prepare financial statements for each financial year in accordance with United Kingdom Generally Accepted Accounting Practice (United Kingdom Accounting Standards) and applicable law.

Under company law the directors must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the company and of its profit or loss for that period. In preparing these financial statements, the directors are required to:

The directors are responsible for keeping proper accounting records that are sufficient to show and explain the company's transactions and disclose with reasonable accuracy at any time the financial position of the company and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

This report has been prepared in accordance with the provisions applicable to companies subject to the small companies’ regime.

Approved and authorised for issue by the board of Trustees and signed on their behalf:

Dr Simon Ridley Trustee

20 January 2026

7

ALZHEIMER'S BRAIN BANK UK

Independent Auditor's Report to the Members of Alzheimer’s Brain Bank UK

For the year ended 31 March 2025

Opinion

We have audited the financial statements of Alzheimer’s Brain Bank UK (the 'charity') for the year ended 31 March 2025 which comprise the Statement of Financial Activities (including Income and Expenditure Account), Balance Sheet, Statement of Cash Flows and the related notes. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including FRS 102 The Financial Reporting Standard applicable in the UK and Republic of Ireland (United Kingdom Generally Accepted Accounting Practice).

In our opinion the financial statements:

Basis for opinion

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the auditor's responsibilities for the audit of the financial statements section of our report. We are independent of the charity in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the FRC’s Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Conclusions relation to going concern

In auditing the financial statements, we have concluded that the trustees' use of the going concern basis of accounting in the preparation of the financial statements is appropriate.

Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the charity's ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.

Our responsibilities and the responsibilities of the trustees with respect to going concern are described in the relevant sections of this report.

8

ALZHEIMER'S BRAIN BANK UK

Independent Auditor's Report to the Members of Alzheimer’s Brain Bank UK (continued)

For the year ending 31 March 2025

Other information

The other information comprises the information included in the annual report, other than the Financial Statements and our Auditor’s Report thereon. The Trustees are responsible for the other information. Our opinion on the Financial Statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon.

In connection with our audit of the Financial Statements, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the Financial Statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether there is a material misstatement in the Financial Statements or a material misstatement of the other information. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We have nothing to report in this regard.

Opinions on other matters prescribed by the Companies Act 2006

Matters on which we are required to report by exception

In the light of the knowledge and understanding of the charity and its environment obtained in the course of the audit, we have not identified material misstatements in the Trustees' Report.

We have nothing to report in respect of the following matters in relation to which the Companies Act 2006 requires us to report to you if, in our opinion:

9

ALZHEIMER'S BRAIN BANK UK

Independent Auditor's Report to the Members of Alzheimer’s Brain Bank UK (continued)

For the year ending 31 March 2025

Responsibilities of trustees

As explained more fully in the Trustees' Responsibilities Statement, the Trustees (who are also the Directors for the purposes of company law) are responsible for the preparation of the Financial Statements and for being satisfied that they give a true and fair view, and for such internal control as the Trustees determine is necessary to enable the preparation of Financial Statements that are free from material misstatement, whether due to fraud or error.

In preparing the Financial Statements, the Trustees are responsible for assessing the Charity's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the Trustees either intend to liquidate the Charity or to cease operations, or have no realistic alternative but to do so.

Auditor's responsibilities for the audit of the Financial Statements

Our objectives are to obtain reasonable assurance about whether the Financial Statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an Auditor’s Report that includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these Financial Statements.

Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, including fraud is detailed below:

Our approach to identifying and assessing the risks of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, was as follows:

10

ALZHEIMER'S BRAIN BANK UK

Independent Auditor's Report to the Members of Alzheimer’s Brain Bank UK (continued)

For the year ending 31 March 2025

We assessed the susceptibility of the Charity's Financial Statements to material misstatement, including obtaining an understanding of how fraud might occur, by:

To address the risk of fraud through management bias and override of controls, we

In response to the risk of irregularities and non-compliance with laws and regulations, we designed procedures which included, but were not limited to:

There are inherent limitations in our audit procedures described above. The more removed that laws and regulations are from financial transactions, the less likely it is that we would become aware of non-compliance. Auditing standards also limit the audit procedures required to identify noncompliance with laws and regulations to enquiry of the trustees and other management and the inspection of regulatory and legal correspondence, if any.

Material misstatements that arise due to fraud can be harder to detect than those that arise from error as they may involve deliberate concealment or collusion.

A further description of our responsibilities for the audit of the Financial Statements is located on the Financial Reporting Council’s website at www.frc.org.uk/auditorsresponsibilities. This description forms part of our auditor’s report.

11

ALZHEIMER'S BRAIN BANK UK

Independent Auditor's Report to the Members of Alzheimer’s Brain Bank UK (continued)

For the year ending 31 March 2025

Use of our report

This report is made solely to the charity's members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the charity's members those matters we are required to state to them in an Auditor's Report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Charity and the Charity's Members as a body, for our audit work, for this report, or for the opinions we have formed.

Mr Shane Tharby (Senior Statutory Auditor) For and on behalf of Streets Audit LLP Chartered accountants & statutory auditor 3 Wellbrook Court Girton Cambridge CB3 0NA

21 January 2026

12

ALZHEIMER'S BRAIN BANK UK

Statement of Financial Activities incorporating an income and expenditure account

For the year ending 31 March 2025

Notes
Income from:
Donations
Grants
2
Legacies
Other income
Total Income
Expenditure on:
Charitable activities
3
Total expenditure
Net income for the year
Total unrestricted funds brought forward
Total of unrestricted funds carried forward
2025
£
200
812,848
119,226
0
932,274
(811,053)
(811,053)
121,221
294,753
415,974
2024
£
277
945,878
1,620
0
947,775
(968,017)
(968,017)
(20,242)
314,995
294,753

The notes on pages 16 to 20 form part of these financial statements.

13

ALZHEIMER'S BRAIN BANK UK

Balance Sheet

As at 31 March 2025

Notes 2025 2024
£ £
Current Assets
Debtors and prepayments 5 1,097,307 1,136,435
Cash at bank 800,916 755,064
Creditors 1,898,223 1,891,499
Research grants due within 1 year 6 (1,050,404) (1,155,673)
Sundry creditors and accruals 6 (431,845) (441,073)
(1,482,249) (1,596,746)
Net Assets 415,974 294,753
Unrestricted Funds 7 415,974 294,753

The notes on pages 16 to 20 form part of these financial statements.

The financial statements on pages 13 to 20 were approved and authorised for issue by the Board on 20 January 2026 and signed on its behalf by:

Dr Simon Ridley Trustee

Company number 05762960

14

ALZHEIMER'S BRAIN BANK UK

Statement of Cash Flows

For the year ended 31 March 2025

----- Start of picture text -----
2025 2024
£ £
Cash flows from operating activities
Net cash (used in)/provided by operating activities 45,852 (85,552)
Change in cash and cash equivalents in reporting period 45,852 (85,552)
Bank cash and cash equivalents at the beginning of the reporting
period 755,064 840,616
Bank cash and cash equivalents at the end of the reporting
period 800,916 755,064
Net income for the reporting period 121,221 (20,242)
Adjustments for:
(Increase)/decrease in debtors 39,128 (91,032)
(Decrease)/increase in creditors (114,497) 25,722
Net cash (used in)/provided by operating activities 45,852 (85,552)
Analysis of changes in net funds 1 April 2024 Cashflow 31 March 2025
Cash at bank and in hand 755,064 45,852 800,916
----- End of picture text -----

15

ALZHEIMER'S BRAIN BANK UK

Notes to the Financial Statements

For the year ended 31 March 2025

Company information

Alzheimer's Brain Bank UK is a registered charity (charity No. 1114578) and a company limited by guarantee and registered in England (company No. 05762960). It meets the definition of a public benefit entity under FRS102.

1 Accounting Policies

Basis of Accounting

The financial statements have been prepared under the historical cost convention. The financial statements have been prepared in accordance with the Companies Act 2006 and Charities SORP 2019 (FRS 102) applicable to charities preparing their accounts in accordance with the Financial Reporting standards applicable in the UK and Republic of Ireland and the Charities Act 2011 and UK Generally Accepted Practice as it applies from 1 January 2019.

Alzheimer's Brain Bank UK meets the definition of a public benefit entity under FRS 102.

Going Concern

The use of the going concern basis of accounting is considered to be appropriate because there are no material uncertainties related to events or conditions that may cast significant doubt about the ability of the company to continue as a going concern.

As part of the Trustees’ review of going concern, discussions with the funding charities are underway regarding the level of funding for the year to 31 March 2027. Draft proposals have been reviewed and the charities have confirmed their commitment to supporting ABBUK until at least that date.

The Trustees have a reasonable expectation that the charity has adequate resources to continue in operational existence for the foreseeable future. No material uncertainties in relation to the ability of the charity to continue on a going concern basis have been identified by the Trustees. Thus they continue to adopt the going concern basis of accounting in preparing the financial statements.

Incoming Resources

Income received by way of grants is included in the statement of financial activities when notified by the sponsoring charities. Bank interest is included on a receipts basis.

Legacy Policy

Legacies are recognised in the statement of financial activities when there is adequate probability and reliability of receipt and their value can be accurately measured.

16

ALZHEIMER'S BRAIN BANK UK

Notes to the Financial Statements (continued)

For the year ended 31 March 2025

1 Accounting Policies (continued)

Resources Expended

All expenses are accounted for on an accruals basis.

Grants to third parties for specific purposes are reflected in the accounts when an agreement is made to commit funds to the project although disbursement of the funds may be made in a subsequent accounting reference period. Other non administrative expenditure has been classified by reference to its function rather than type of expense so that all costs relating to a specific activity have been aggregated. The basis of allocation is reviewed regularly.

Funds

All funds are unrestricted and are available for use by Alzheimer's Brain Bank UK within its charitable objects at the discretion of the Trustees.

Financial Instruments

Alzheimer's Brain Bank UK has financial assets and financial liabilities of a kind that qualify as basic financial instruments. Basic financial instruments are initially recognised at transaction value and subsequently measured at amortised cost. Financial assets held at amortised cost comprise cash at bank and in hand, together with debtors. Financial liabilities held at amortised cost comprise grants payable, creditors and accruals.

2 Grants
Grant from Alzheimer's Society
Grant from Alzheimer's Research UK
less amount no longer required
2025
£
489,290
489,290
978,580
(165,732)
812,848
2024
£
567,717
567,718
1,135,435
(189,557)
945,878

During the year refunds were issued to take account of underspends for BDR4 year 4 to the value of £165,732 (2024: underspends for BDR4 year 3 to the value of £189,557).

Alzheimer's Society & Alzheimer's Research UK are related parties by virtue of the fact that the trustees of Alzheimer's Brain Bank UK are nominees of these two sponsoring charities.

17

ALZHEIMER'S BRAIN BANK UK

Notes to the Financial Statements (continued)

For the year ended 31 March 2025

3 Charitable Activities
Research Grants:
University of Bristol
University of Cardiff
King's College London
University of Manchester
University of Newcastle
University of Newcastle (Co-ordinating Centre)
University of Oxford
Amount no longer required
Associated support costs (note 4)
4 Support Costs
Management fees - payable to Alzheimer's Research UK
Audit and external examination fees
Other expenses
2025
£
134,949
72,641
160,358
101,465
112,792
270,357
86,018
938,580
(165,732)
772,848
38,205
811,053
2025
£
30,000
7,610
595
38,205
2024
£
137,155
72,541
155,223
95,593
113,207
448,587
92,929
1,115,235
(189,557)
925,678
42,339
968,017
2024
£
30,000
11,400
939
42,339

Included within audit and external examination fees is £7,610 for audit fees for 2024-25 payable to Streets Audit LLP (2024: £6,600 for audit fees for 2023-24 and £4,800 for audit fees for 202223).

5 Debtors
Amount owed by related parties due within one year:
Alzheimer's Society
Alzheimer's Research UK
Accrued income
2025
£
489,290
489,291
118,726
1,097,307
2024
£
567,717
567,718
1,000
1,136,435

18

ALZHEIMER'S BRAIN BANK UK

Notes to the Financial Statements (continued)

For the year ended 31 March 2025

6 Creditors
Amounts falling due within one year
Research grants
Amount owed to related parties
Other creditors and accruals
Research grants due in more than one year
Research grants creditors payable within one year
Reconciliation of Research grants commitments
Balance brought forward
New commitments entered into
Commitments no longer required
Amounts spent in the year
2025
£
1,050,404
173,232
258,613
1,482,249
-
1,050,404
1,155,673
938,580
(165,732)
(878,117)
1,050,404
2024
£
1,155,673
197,058
244,015
1,596,746
-
1,155,673
1,210,751
1,115,235
(189,557)
(980,756)
1,155,673

ABBUK has entered into agreements with 6 research centres, to provide funding over a 5 year period ending 31 March 2026. The funding commitment is subject to an independent, thorough systematic review, and future funding levels are committed on an annual basis with the funding having been awarded for the year ended 31 March 2026 as at the balance sheet date. The annual commitment in 2025-26 will be funded out of grants, donations and legacies.

Movement in Funds - Unrestricted
Balance bought forward as at 1st April
Net incoming resources for the year
Balance carried forward
2025
£
294,753
121,221
415,974
2024
£
314,995
(20,242)
294,753

7 Movement in Funds - Unrestricted

8 Transactions with Trustees

The trustees neither received nor waived any emoluments during the year (2024 £nil) and £nil of out of pocket expenses were reimbursed to Trustees (2024: £395).

19

ALZHEIMER'S BRAIN BANK UK

Notes to the financial statements (continued)

For the year ended 31 March 2025

9 Members' Liability

The company is limited by guarantee and does not have a share capital. The number of members at 31 March 2025 was 2 and their liability in the event of a deficiency of assets on winding up of the company is limited to £10 each.

10 Related Parties

Alzheimer's Research UK and Alzheimer's Society share the ownership and risks of the joint venture company.

During the year, the company received grant income from both entities, as detailed in note 2.

During the year, Alzheimer's Brain Bank UK were charged the following amounts for the provision of management services:

of management services:
2025 2024
£ £
Alzheimer's Research UK 30,000 30,000
As at 31 March 2025, the following balances were outstanding with related parties:
2025 2024
£ £
Owed by Alzheimer's Society - grant funding 489,290 567,717
Owed by Alzheimer's Research UK - grant funding 489,291 567,718
Owed to Alzheimer's Society - refund of grant funding 82,866 94,778
Owed to Alzheimer's Research UK - refund of grant funding 82,866 94,779
Owed to Alzheimer's Research UK - management services 7,500 7,500

20