2024-03-31-accounts

MULTIPLE SCLEROSIS TRIALS COLLABORATION FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2024 Registsred Charity No. 1113598 Coop•r P¥ry Advhory Umlted AJssela 46 High Slreet Esher Surr Kf10

PAULTIPLE SCLEROSIS TIOALS COLLA80RATION FINANCIAL STATEMEtrifs FOR THE YEAR ENDED 31 PAARCH 2024 coKrEMrs PAGE Legal and adnvaiistrth dth Report dthe TnJste85 Balancé $t*et

MULTIPLE SCLEROSIS TRIALS COLLABORATION LEGAL AND ADMINISTRATIVE DEfAILS Tru8to•• Jerwny Chatsway - Charman Omar Malik Richard Nith)las Addre 10L18 Labornw Block Charng Cross Campus IM￿1181 col￿ge Londc Fulham Palac8 Road H8￿￿e￿milh London v￿ 8RF Charlty Nthnbar 1113598 Accountants and Independent EX￿IDer4 Cooper Parry hA￿1￿Y Lknited New Derwerrt House 69-73 Theobalds Road L18TA

MULTIPLE SCLEROSIS TRIALS COLLABORATION REPORT OF THE TRUSTEES FOR THE YEAR ENDED 31 MARCH 2024 The Trustees present their annual report and the fmancial staiements for the year erthd 31 March 2024. St•tus Muttiple Sderosis Trials CollaboratK)n eSt￿Ashed a corrstihrtion dated 13 Januwy 21Th and is registered as a tharity in England andWas. Managemwit The charity is nwnaged by ils trustees. A full list of trustees servng during Ihe is gi￿ on page 1. Rlsk Man•gem8nt The truslees examlne the maicff risks whlch the (tsrity fac85 and seek to CAYrtrol thesè risks to mitigate any impact that they may have on Ihe dwrty. Ob nd Acllvltles The oty'e(ves of the are: To 8SSBt in the treatment and care of persons suffering frc#m Muftiple Sclerosis IMS) in the West Lnndon area. To adyance the education of the general publ￿ in all areas relating to MS. To p[D￿de patients with MS. who are suitable ts cu￿ent therapies. access to pharmKeulical-spon50red dinical trials. Furthermore to use incorne general￿ ty urxjertaking phanr￿eut1Cal dinical trials to devise and administer research4ed dinical trials thereby FKoviding 9￿ater ac£ess to ￿t￿lia1 treatrrnts to more MS patients. Durlng the yew the charity has colleded fijnds in ￿der to make ￿artS to organisation5 to further these tharitable obiedr4es. Flnanclal Revlthv The charilys net in(x)n forthe Y￿ ended 31 2(Y22 was £51,4(MJ {2022 ￿ ¥¥x￿￿'. £31,631). Totsl fvnds at 31 March 2023 amounted to £264.786 (2022: £213.446). AJI resour￿ experKled durin9 the year tre applied in aC£Ordan￿ with the obj'ectives ofthe charty. Po The charity has very fthv f￿ed overheads arKI requres lirnled reserves. Its ojrrent pofry is to hold un￿str￿￿ed. Undes￿nated reserves sufficient to cover three months Operat￿al eXpe￿litt￿e. The reswves th1ou￿QuI the Ye￿ and al the year end have been li line vrith this ￿￿cy. The trustees e responsible wepanng the Trustees. Arn￿1 Report and the finani?al statennts in acc(￿darKe Viith aWicabie law atKI Unitgj lfjngd(ffi ACCI￿nting Standards (Untted Krybm General￿ Ac£epted kcounting Practice). The law applThbk to charities in England & Wales requyes the trustees to p￿pare finartial Statements for each financial year vthich gtve a true and fair vi￿4 of the state of affaws of the tharty a￿1 ofthe incorning resources and appliCa￿n of resources of the charity for that period. In weparing these financlal stalwTEnts. the ljvslees we requyed to: setect suitablè aco)unting polides and then appty thwn (x)nsFtertty: obseNe the methcxls and prindples in the Charities SORP; make jud9ements and estimates that are reasonable and w￿nI. state whether applicable ￿lunting St￿da￿S have been folkmed. suty'eLI to any Ma￿la1 departures disclosed and explained in the financial staterrents: prepare the financial statsrnwts on the going basis ￿lesS It is Inapprowote to presuff£ that the tharity w￿1 continue Sn operatlon. The trustees are responsible for keeplng prO￿r accwntfng recxirds that disck)5e ryth reasonable acojracy at any time the financial Isition crfthe thanty and enable them to ensure that Ihe financial staternerts compty the Charilbes Act 2011. the Charities (Accounts and Rep(xts) Regulations 2(XJ8 and the wo¥isions of the trust deed. Try are also responsible for safeguarding the assets of the charity and herm* taking reasonabSe steps for the weveMb)n and detedion of fraud and other vregularities. This report was approved by order ofthe Board o 6( ne 2025 aThJ its b&hall ty. R Nl¢holas (fnMts•)

INDEPENDEKf EXAMINERS REPORT TO THE TRUSTEES OF MULnPLE SCLEROSIS TRIALS COLLABORATION We report to the chanty lJustees on our ex3minatK)n of the a¢xounts of the tharlty for the year ended 31 Marth 2¢r24 bthicti are set oul on pages 4t0 8. Re8pon8lbllltleg and basls of report As the tharrty's truste8s you are rnsponble frx lThe FYeparatk)n of the ￿)Unts in acix)rdarr vrith reqUirw￿nts of the CharrlFes ALt 2011 (Ihe Ad'l. We rewrt In respect ol my examlnatbn of the charity's ar£ounts Ca￿led out under Se￿￿￿ 145 of Ihe arnl in Ixrying out our examina￿n V4? have folk)%￿d the DreGlions 9p￿n ty the Charity CM)missbn under sedion 145(5){b) of the Indèynd•nt •xamln•f• 8tst•ment We have ￿1Pleted ￿aMInatIOn. We confirn that no m8ttws to ow atten￿n In (xlnnedth with the examiiatlon g￿ing us Gause to beLwe that in any material accounting re¢Th￿S V￿re keo in respecl of the chartty 88 requlred ty se(thn 130 d the kl: the 8rxounts do n(rt acclxd those rec(Yds.' the aCcc￿nts (k) c£npty ryth the applicable reoJk•nents o)n¢eming the fomi and content of accounts set rArt in Charities (Ac£ounts and Rep￿5} Re9ulalions 2008 other than any wulreffnt that the aco)unts ghe a arKI falr Is not matter considered as part of an independent exaninat)n. We have no COn￿mS arvj have across no other matter5 in connedk)n ¥￿th the examviatw)n to wthkh attertM)n shoukl be dravm In this rew1 in Lyder to enable a proper unde(anding ol the ￿lUnts to be reathed. Cooper Parry Advl•ory Umlt•d Aissela 46 Hlgh Street Esher Surrerf Kf10 &￿y Jun• 2025

MULTIPLE SCLEROSIS TRIALS COLLABORATION STATEMEiif OF FIPiANCIAL ACTMTIES FOR THE YEAR ENDED 31 MARCH 2024 Unrn•trlct•d Fund• Restslcted Funds Y••rto 2024 Year to 2023 In¢omo and •ndoinent• from: Donat￿n$ and legades Charitable adhities Interest inttme 102,261 551 551 327 Totsl IrN>xne Expendlturo on: Grants and Oonalions Pald Charilatle adNities 14.458 1,621 14.458 1.621 49,734 1,514 Tolal expenditijre Net {expwKlitweYincome and net mOV￿nI n fvnds Reconclllailon rf lund¥: Total funds Ixouglft f(Nward 264,586 10.21)) 264.786 213,446 Total fund• ￿rrI￿ forward 289 058 2￿ 258 The ndes on pages 6 to 8 fomi part ofthese ￿na￿A81 statennt&

MULTIPLE SCLEROSIS TRIALS COLLABORATION BALANCE SHEEf FOR THE YEAR ENDED 31 PAARCH 2024 2024 2023 Currerrt auets: Cash at bank and in hand 316,596 316. 287,426 267.426 Crndltorn: Amounts falling due v￿￿rn t)ne yeBr Net current a8s•ts Total ass&s less oJTheM liabHIUes 299.258 2S4,786 299 258 264 786 Fund• UnrestrKled funds RestrlLted fvnds 289.058 10,21X) 264.786 10,2(K) Total fund8 ￿lFI•d loThvanl The finandal Statements wwe approved ty board on une 2024 and slgned on ts behall ty. R Nlchol8 Truste• The n(es on pages 6 10 8 form part of It￿ rma￿￿al staten*n

MULTIPLE SCLEROSIS TRIALS COLLABORATION NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2024 Accountlng FK>llcl•• The prin(ipal 8CrJ)u￿ng politxs are set (xrt bekpw. The wJx)unling w)fKies have been ajoptsd C￿siSteni￿ throughout the year. Bas1• of preparfng tho flnancll •talem•nts The fmanoal statements have been wepwed in 8ccx)rdaThx with ACCO￿11rvJ arKI Reporting ty Charitles.. St8temenl of Recommended Practice appfKable to charities wepwing ther acc£wnts in ac0)rda￿e with the FInar￿la1 Reporting Standard appfuble in the UK Wtd Republ￿ of Ireland Issued in Odober 2019, the Fi￿n(JaI Rewting Stsndard applThble in the Unfted Klngdom and Re￿b￿ of Ireland (FRS 102) and the Charit￿S Ad 2011. The financlal stalerrnnts been prepared uThler the hist(￿￿1 cost ￿nvent￿n arKI are prepared cffl a going concern basis. Muluple Sderosis Trials CcAlaboralion meèts the def￿lI￿n of a public benefit entty u￿ler FRS 102. Golng ¢orK•rn The finan(3al statenxnts have been prepared on a gdng cJ￿rn basr3 as the tntstees believe thal no materwl urtertantles exisl. The tA￿tee$ ha￿ consKlwed the level of furKls held aTrJ the ￿r￿ded level of inc4Nne and expendtture for a minynum 12 months frcffl the aUt￿nSati￿ ofthese finarrtial slaternents In arriving at this c(J)dusion. The budgeted wic{￿ and expenditure Is sulhsent ith the level of resw4es for the tharty to be able to continue as a going concxn. Judgement and key sources ￿ èslknallon unc•rtslnty The of the finanrjal statwrrts requyes M￿agaI￿rt to make ludgwnents. estinates and asswnrthns that aff&t the amunls rewted. These est￿aleS ar¥J Judgements a￿ conlinuafty reNryev￿d and we based on exwence and other faclors. incbJdiTrJ expedatM)ns of fuiwe wents that are beSewJ io b8 reasorAble urnler Ihe (arumstsnces. AU irKJ)ming resources are induded in the Stat￿nI of financ¥g1 aclr4itses then the tharity is entrtled to the inccrfne and tho amount ￿ be qU￿tified vAh reasonable a￿￿ac￿. The foQ(hwKJ polcies are aPp￿dt0 parth%kr c2teg(xÈs of income.. £knat￿S and legacies Tecei¥ed ty way of d(￿￿tK)nS and gifts ￿e recognised in the in thich they are receplable. Incc4ne fm th8rrfable ativJtses is WKluded vi the period in it is receib7t4e. Expendlturn Expenditwe is fecognised on an a(yJuals basis as a labilty is InoJrred. The lo1￿￿ng speafL POS￿ are applied to parthwlar categ(Ths of expenditwe: E¥penditure ch8nlable xtmtts is by the djarity n the cowse ofmeetiFWJ its tharitabte aims induding grant mak¥Jg and related governar￿ and supwt costs Fund 8tructur• un￿￿￿K￿ed general fvnds- the Yree. fuThts held ty the dwty to be used a¢x(Kdm vfith the thaTable oty'eds at the dISuet￿tn of the trustees. Restihl8dfunds- fvnds held to be used onty ts restrKed p￿pOSe5 the otye(As crf the cknrFty. Restrwxions arlse wtwi by don(Y5 and grnnt rna￿ng or vthen fvnds we raiwj for pwtKul8r wrposes. Incom• and endcwm•nts Unrnstrlcted Fund• Year to 2024 Year to X123 DonalM)ns and legaw- Donath)vki Charitsble adriibes- Trials incc¥M 102,261 551 327

MULTIPLE SCLEROSIS TRIALS COLLABORATION NOTES TO THE FINANCIAL STATEMEKfs FOR THE YEAR ENDED 31 MARCH 2024 Expendlture on charttable actlvllles Yearlo 2024 Yo•rto 2023 Fund• Gr•nts 4nd don•llons p•ld Imterf81 Cole Trust Epilepsy Socaety Hellenic Paslew S(Klety Universty College London 14,458 14.458 49.734 Support costs •ttrfbuthble fo grantmaklnp •nd don•dons Salarles aTrJ trtal fees Travel cx)sts Palient tran8POrt Office expenses Profess#)nal fees MS Flm AccJ￿rftancY Miscelaneous expenses 1.440 74 81 61 Totsl expenditure on thwitable athitkns Expendllwe on d￿lIat￿e activls In 2024 was ertlrety attrI￿rtable to urnstrnled funds. Tru•l•o r•fflun•r•llon and oxpenws and koy man•gwnent pw8onn No truslees ￿ persons c￿￿eded wilh thern re￿Ne￿j emo1u￿nts in their role as tnBtees fr¢￿ the dwrty (2023". niQ and no trustee5 have recer¥d Pa￿]enIfor FKofessional w other ￿ provwjed to tl tharty during the year (2023: nil). IndN>Jual expenses 1¢Xa￿In9 nil for tra￿ and subsistence to meetings and C(￿f￿ertr￿ (2032: nl) were re1mt￿rWj to ￿e trustee during the yew. The trustees cjynwsed the key r￿nag￿nent ￿rs(￿ne1 of the charity dsrng the yeaf5 erKllng 31 Marth 2024 and 31 March 2023. The chanty did not employ any merrt)er5 of stsff durirs Ihese yeaTs. Crodltor• Year to Y•ar to 2023 Acuued warAs payable Accrued support cx)sts 14,458 2,880 2,640 17.338 Unmtrlct•d fund• Balance at 0110th23 Balance at 3110312024 Year •nded 31 March 2023 Inc(¥n• Exp•ndlturn Tran8for8 Genwal funds 254.586 50.551 (16.079) 289,058 254.586 51.248 289,058 Balar•ce at 011W2022 Balance at 3110￿2023 Y••r •ndod 31 M•rch 2023 Inc Exp•ndltur• Trarb•forn Genefal funds 203.246 102.588 (51248) 254,586 51248 254.586

MULTIPLE SCLEROSIS TRIALS COLLABORATION NOTES TO THE FINANCIAL STATEMEpifs FOR THE YEAR ENDED 31 MARCH 2024 Restrfctod fund• Balanc• at 0110412023 Balance at 3110J2024 Year anded 31 Ma￿h 2024 Inc(xn• Expèndlturn Trdnsf•rn 10,2(KI 10,2IKI Balance at 0110￿2022 Balance at 3110Y2023 Year ended 31 March 2023 Inc(xM Eyndlturn Transfer4 Genzyme Th￿rap￿rt 10.2 10.200 10.200 Name of fund Genzynp TrrapwA Funds hehj for the wrpose of makNIg a wl fty the wrchase of an infusion pJmp. Analysls rA net assets bet¥•wn funds Year ended 31 March 2024 Funds Funds Total Currerrt assets Cuffent liabilities ,398 (17.338) 102(K) 316,596 (17.338) 289.058 10.2 299,258 Unrestrlcted Funds Restrlcted Funds Year ended 31 March 2023 Total 257.226 (2,640) 10.2(Kl 267.426 (2.640) Current liabl￿tte3 10.200 264 786 Detals of trustee emolrnnts and expertses are di5d￿d ￿ note 4. There are no cther felated paty trdnsadKW15 to repo