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← Prevent Breast Cancer

2025-03-31-accounts

Prevent Breast Cancer Annual Report and Financial Statements For the year ended 31 March 2025

Using science to save lives

2 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Contents

Trustees’ Annual Report

A Message from our Chair ..................................................................................................................... 5 About Us .................................................................................................................................................... 7 The Need .................................................................................................................................. 7 Out Mission ............................................................................................................................. 7 Public Benefit .......................................................................................................................... 8 Grant Making Policy .............................................................................................................. 8 Charitable Activity .................................................................................................................................10 Digital Impact..........................................................................................................................................11 Research Programme ............................................................................................................................13 Our Philosophy .....................................................................................................................13 Risk Prediction ......................................................................................................................13 Research Strategy ................................................................................................................14 Looking Ahead: Our Research Goals to 2030 ................................................................15 Previously Funded Research Projects: Updates ............................................................17 New Research Projects .......................................................................................................19 Research Plans for 2025-2026 .........................................................................................20 The National Breast Imaging Academy .............................................................................................22 Supporting Patients and Professionals at the Nightingale Centre .............................................24 Outreach and Awareness .....................................................................................................................26 Health Inequalities ................................................................................................................................30 Year in Review ........................................................................................................................................36 Fundraising Highlights ..........................................................................................................................44 Strategic Aims and Objectives ............................................................................................................50 Financial Review ....................................................................................................................................52 Structure, Governance and Management ........................................................................................56 Reference and Administrative Details ...............................................................................................58 Statement of Trustees’ Responsibilities ............................................................................................60 Financial Statements

Independent Auditor’s Report ............................................................................................................62 Statement of Financial Activities .......................................................................................................65 Balance Sheet .........................................................................................................................................66 Notes to the Financial Statements ....................................................................................................68 Statement of Cash Flows .....................................................................................................................71

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 3

4 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

A Message from our Chair

Dear Friends and Supporters,

I am delighted to share highlights from another remarkable year at Prevent Breast Cancer – a year defined by significant progress, renewed momentum in research, and the unwavering support of our incredible community.

One of our most exciting milestones this year has been the progress of the National Breast Imaging Academy, which will be completed in November 2025 and fully operational in early 2026. This achievement has only been possible thanks to the extraordinary generosity and commitment of our supporters, and we are truly grateful.

The main focus of the year has been our public appeal to raise the remaining funds required to complete the project. Thanks to the tireless work of our team and the unwavering support of our donors, we are delighted to announce that, as of September 2025, this goal was successfully reached.

The Academy will address the national shortage of breast imaging professionals by developing a sustainable and skilled workforce, equipped to meet both current and future screening demands. It will also enable faster diagnoses and earlier access to potentially life-saving treatment for thousands of patients, while serving as a hub for advancing research. You can read the full Academy update on page 22.

As a result of the capital campaign, very little was spent on new research during the year to 31 March 2025, as resources were prioritised for the Academy. However, a major highlight has been the return of our research programme, which lies at the very heart of our charity’s purpose. Thanks to the success of our fundraising during the financial year, we were able to reopen our funding round in December 2024, with final decisions on supported projects made in June 2025. You can learn more about our research programme and new projects on pages 13-20.

We are also tremendously pleased to report that, during the year, we laid the groundwork for the establishment of the Prevent Breast Cancer Research Unit (PBC-RU). By centralising and expanding our research capabilities, training the next generation of prevention researchers,

and strengthening leadership in cancer prevention, the PBC-RU will not only reinforce Manchester’s position as a leading hub for breast cancer prevention but also contribute to global efforts to eliminate the disease.

While the funding for this major initiative falls into the new financial year, key discussions and planning took place during this period, with a final funding decision made in June 2025. We are excited to be working towards formally launching this important development later in the year. You can learn more about the PBC-RU on page 15.

Finally, we’re also proud of the progress we’ve made in addressing health inequalities through our community outreach work. This year, our mobile Community Breast Awareness Hub (a converted horsebox) has been deployed across Greater Manchester, helping us connect with under-served communities. It provides a safe, approachable space where people can learn about breast health, ask questions, and access vital screening information. Read more about it on page 29.

On behalf of the Board of Trustees, I would like to extend our heartfelt thanks to everyone who supports Prevent Breast Cancer – from our volunteers and fundraisers to our patrons and ambassadors. Your passion, time, and generosity help bring our vision closer every day: a future where breast cancer is preventable for generations to come.

We are using science to save lives – and we couldn’t do it without you.

With sincere thanks,

Eamonn O'Neal

Eamonn O'Neal (Dec 2, 2025 13:48:14 GMT)

Eamonn O’Neal OBE DL

Chairman of Trustees, Prevent Breast Cancer

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 5

Let’s get ahead of breast cancer

Breaking the cycle of breast cancer means thinking bigger.

That's why we're all-in on using science to save lives.

We're the only charity to focus all our research on the prediction, prevention and early detection of breast cancer.

6 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

About Us

The Need

==> picture [35 x 172] intentionally omitted <==

Our Mission: Predict, Prevent, Protect

At Prevent Breast Cancer, we are the UK’s only charity solely focused on breast cancer prevention research grounded in clinical practice. Using science to save lives, our mission is to make breast cancer a preventable disease for future generations by funding vital research into its prediction, prevention and early detection, so that no one has to go through it in the first place.

Since becoming a registered charity in 1997, we have committed over £5.4 million in grants to clinical and laboratory research aimed at preventing breast cancer. This investment has driven major breakthroughs – from identifying previously unknown gene fragments linked to breast cancer, to transforming how screening is delivered.

Headquartered in Manchester, we are a national charity supporting research projects across the UK. We are embedded within the University of Manchester, which informs our research and strategy as we work closely with researchers, clinicians, and data scientists. While independent of the NHS, we maintain strong partnerships with breast cancer services, including screening programmes and family history clinics, ensuring our research directly informs clinical practice and real-world patient outcomes.

Beyond research, we’ve invested over £744,000 in sharing our scientific findings with the national and international community, and a further £2.96 million in breast awareness initiatives, with a focus on tackling health inequalities and improving community health outcomes.

We are proud to be based at The Nightingale Centre at Wythenshawe Hospital, which we helped build with a £2 million fundraising campaign completed in 2007. Since then, we’ve contributed a further £2.46 million to its development, helping enhance both patient experience and staff support.

Our research is focused on four key pillars: gene research, screening innovation, lifestyle and environmental risk factors, and preventative therapies.

  1. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer

  2. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer

  3. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer

  4. https://breastcancernow.org/about-us/why-we-do-it/breast-cancer-facts-and-statistics/

  5. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer

  6. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/breast-cancer/incidence-invasive

  7. https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/healthcaresystem/datasets/healthaccountsreferencetables

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 7

The Centre houses the Greater Manchester NHS Breast Screening Programme and the Family History Risk and Prevention Clinic, and it also serves as a base for many of our researchers. Their innovative clinical studies focus on accurately identifying women at higher risk of breast cancer, so that preventative interventions can be offered before cancer develops. Being based at the Centre also ensures access to a diverse cohort of participants, making our research stronger, more inclusive, and more impactful.

Public Benefit

Our Trustees are fully aligned with the Charity Commission’s guidance on public benefit. Prevent Breast Cancer is dedicated not only to funding worldclass research into the prediction, prevention, and early detection of breast cancer, but also to ensuring that the knowledge we generate translates into real-world impact.

We believe that prevention and early detection should be for everyone. That is why we invest significantly in community outreach, education and awareness campaigns, especially in under-served and marginalised communities where health inequalities are greatest. Our outreach programmes aim to improve understanding of breast cancer risk, promote early detection and empower individuals to take control of their breast health.

We also provide pastoral and practical support to patients and staff at The Nightingale Centre and we continue to invest in national infrastructure to support breast screening and prevention. This has included helping to establish the National Breast Imaging Academy which is addressing workforce shortages and helping to futureproof breast screening across the UK, improving outcomes for thousands of women each year.

Taken together, our research, education, outreach, and infrastructure investment ensure that the public benefit of our work is wide-reaching, inclusive, and long lasting.

Grant Making Policy

Prevent Breast Cancer funds high-quality research that advances the prediction, prevention, and early diagnosis of breast cancer. While we frequently support research teams based at The Nightingale Centre and the Manchester Breast Centre, we also actively welcome applications from institutions across the UK. We are a non-commercial partner of the National Institute for Health and Care Research (NIHR), ensuring our funding processes meet national standards of excellence. As of

the 25th September 2025, Prevent Breast Cancer is an introductory member of the Association of Medical Research Charities (AMRC) and will be working towards full membership over the next two years.

All grant applicants are required to complete a Prevent Breast Cancer grant application form, which is submitted to our Scientific Advisory Board (SAB) for thorough assessment. The SAB is chaired by Professor Cliona Kirwan, Clinician Scientist in Surgical Oncology and Consultant Oncoplastic Breast Surgeon.

Each application is evaluated based on the scientific quality and innovation of the research plan, its relevance to breast cancer prediction, prevention and/or early detection, the potential public health impact, and overall feasibility and value for money. Projects that do not align with our mission or scientific standards are not considered for funding.

For funding requests over £30,000, applications are first reviewed internally by a SAB member who is independent of the project. If deemed suitable, they are then assessed by at least two external reviewers, also independent of Prevent Breast Cancer and the host institution. The reviewers complete formal assessments and provide scores and recommendations.

For requests between £10,000 and £30,000, the application is reviewed internally by three SAB members, all independent of the project. These proposals must clearly address one or more of our core research priorities: prediction, prevention, and/or early detection.

Requests for £10,000 and below (such as those for pilot studies, consumables, equipment or contributions to ongoing projects) are not sent for peer review. Instead, they are assessed by a SAB member for scientific and strategic fit, with final decisions made by the Board of Trustees.

All applications recommended for funding are presented to the Board of Trustees for final approval. Any SAB member with a conflict of interest is excluded from discussions and decision-making processes to maintain objectivity and transparency. While members of our SAB are eligible to apply for funding, they are not involved in the assessment, discussion, or approval of their own or competing applications during that grant round.

This rigorous and impartial system ensures that every project we fund has strong scientific merit and clear potential to prevent breast cancer and improve public health outcomes.

8 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

“We fund high-quality research that advances the prediction, prevention, and early diagnosis of breast cancer”

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 9

Charitable Activity

In 2025, Prevent Breast Cancer strengthened its work across three core areas of charitable activity: advancing research, raising awareness, and . promoting equity in breast health

We continue to fund world-class scientific research focused on understanding how to predict, prevent and ultimately stop breast cancer before it starts. Alongside this, our outreach and awareness programmes have expanded, helping more people recognise the signs and symptoms of breast cancer, understand their risk factors, and access screening at the right time.

A growing focus of our work is tackling health inequalities, ensuring that every individual, regardless of background, has equal access to information, screening and preventative care. Through targeted campaigns and deepening partnerships with community organisations, we are working to break down barriers, build trust and empower everyone to take charge of their breast health.

==> picture [489 x 416] intentionally omitted <==

----- Start of picture text -----
We spent £1,232,274
on Charitable Activity
Outreach and Awareness £449,403
Patient Care and Services to the Centre £298,784
Building the National Breast Imaging
£239,787
Academy
Addressing Health Inequalities &
£108,148
Forever Manchester Grant
£ Publicising and Disseminating Research £82,647
Research Grants £53,505
Restricted reserves include:
The charity holds
£1,167,448
£1,553,828 for the building of a National Breast Imaging Academy
£302,920
as restricted income carried to fund Gene Research
forward to 2025-2026 for future
£83,460
charitable expenditure.
for our work to address health inequalities
----- End of picture text -----

10 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Digital Impact

Our digital channels continue to play a vital role in spreading awareness, educating the public, and building a community around breast cancer prevention.

Over the past year, our website received 212,004 visits, with homepage views increasing by 83% - a clear sign of growing engagement.

On Instagram, our most viewed reel came from a collaboration with Sculpt Activewear, celebrating ambassador Roisin Lawlor – garnering 25.5K views and over 500 likes.

Other top performing reels included breast check guides, podcast partnerships and a powerful screening message from Patron Sally Dynevor.

We are incredibly grateful to our patrons and ambassadors, whose support across social media has helped us reach wider audiences and share essential messages around prevention.

We published 49 blogs – 16 more than last year, – covering everything from personal stories to the latest advances in prevention research.

Media coverage has also been strong, with 2267 pieces of press across regional and national outlets including The Guardian, The Independent, BBC One North West and Granada Reports.

On YouTube, our videos were watched 13.6K times. The most popular videos were our expertled content, such as breast checks with Professor Cliona Kirwan and conversations around male breast cancer with Rajiv Dave.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 11

Since 2010 we have invested

over £5.4 million in cutting-edge research

12 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Research Programme

As fundraising for our priority project - the National Breast Imaging Academy - neared completion, we took the important step of re-opening our research funding programme, reaffirming our core mission and supporting a new wave of innovative studies across the UK.

We fund research from leading academic institutions nationwide, building a collaborative network of scientists, clinicians, and health professionals working together to stop breast cancer before it starts.

Our Philosophy

Prevent Breast Cancer is proud to lead the way in breast cancer prevention research in the UK. Unlike many organisations focused on treatment, we are the only UK breast cancer charity entirely dedicated to prevention.

We believe that prevention is better than cure – not just because it saves lives, but because it spares individuals and families from the trauma of diagnosis, surgery, chemotherapy, and long-term treatment side effects. Our work centres around the idea that no one should have to hear the words “you have breast cancer” and we are using science to make that vision a reality.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 13

Our Strategy and Goals

Breast cancer is a complex disease with many contributing risk factors: genetic, lifestyle, environmental and biological. Our strategy focuses on tackling each of these risk factors through a coordinated, evidence-based approach – simply put, using science to save lives.

We structure our research around four strategic pillars, each addressing a critical area of prevention, with clear goals looking ahead to 2030.

Gene Research

Understanding genetic risk is fundamental to predicting who is most likely to develop breast cancer. We investigate major gene mutations, such as BRCA1 and BRCA2, and tiny gene variations called SNPs that significantly impact breast cancer risk. Our research also explores the genetic links to breast density, a key biological risk factor, to improve risk prediction even further. This knowledge allows us to offer tailored prevention strategies to those at greatest risk.

Our goals to 2030:

Screening & Early Detection

Screening is one of the most powerful tools we have to save lives – especially when it detects breast cancer at its earliest, most treatable stage or identifies precancerous changes before disease develops. We aim to improve the accuracy and effectiveness of the UK breast screening programme and champion personalised, risk-adapted screening. By assessing someone’s individual risk – including genetic factors, breast density and lifestyle – screening frequency can be tailored, ensuring that high-risk women are monitored closely and low-risk women are not over-screened.

Our goals to 2030:

Lifestyle & Environmental Risk Factors

Our research investigates how changes in diet, exercise, alcohol consumption, weight, and other factors can reduce risk. We are also exploring whether lifestyle or medical interventions can lower breast density, potentially reducing risk and improving screening effectiveness.

Our goals to 2030:

We are also developing better approaches for women with dense breast tissue, which can make cancers harder to detect on standard mammograms, and creating tools to support earlier diagnosis in these women.

14 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Preventative Drugs

For those at higher risk, certain medications can reduce the likelihood of developing breast cancer. We support trials assessing the effectiveness of both new and existing risk-reducing drugs, such as tamoxifen and anastrozole. We also investigate how these drugs influence breast density, both as a mechanism for risk reduction and as a potential biomarker for response, helping identify more effective and better-tolerated preventative options.

Our goals to 2030:

Together, these four pillars form a comprehensive and interconnected strategy for stopping breast cancer before it starts. By embedding emerging research, including the role of breast density, into all aspects of prevention, we are making meaningful progress toward a future free from breast cancer.

Introducing the Prevent Breast Cancer Research Unit (PBC-RU)

The PBC-RU will be central to our future research strategy, providing focus, coordination, and investment to the most promising areas of prevention science. Its work will ensure the long-term sustainability and amplify the impact of breast cancer prevention research led from Manchester.

Research Resources

Prevent Breast Cancer is uniquely positioned to drive forward prevention research through our location, strong collaborative networks, and significant investment in infrastructure and resources:

We are excited to announce the creation of the Prevent Breast Cancer Research Unit (PBC-RU) - a major step forward in our mission to prevent breast cancer.

Launching in 2026, this virtual unit will bring together our city’s world-class scientists, clinicians, and data infrastructure to create the UK’s leading hub for breast cancer prevention research. The PBC-RU will:

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 15

16 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Previously Funded Research Projects: Updates

The following projects were funded in our 2022 grant round and have continued to make significant progress in advancing breast cancer prevention, risk prediction, and early detection:

Improving Risk Prediction for Young Women with Breast Cancer

Project Lead: Dr William Tapper, University of Southampton.

Young onset breast cancer (YOBC) is typically more aggressive and presents different risk factors than breast cancer in older women yet remains poorly understood. This study aims to improve risk prediction for younger patients by developing a polygenic risk score (PRS) tailored to their unique genetic profiles. Researchers are investigating the relationship between inherited DNA variations and tumour-infiltrating lymphocytes or TILs (immune cells known to influence treatment response).

Dr Tapper’s team has now genotyped DNA samples from 2,811 women with YOBC, analysing over 1.5 million genetic variants. They also updated long-term health records for these patients, capturing outcomes over an average of 17 years. The next phase will involve assessing existing PRSs and developing a new, more accurate version optimised for younger women. The study also aims to identify genetic variants linked to immune activity in tumours, opening the door to more personalised, immune-based prevention and treatment strategies.

The Search for Hidden Mutations in Familial Breast Cancer

Project Lead: Dr Miriam Smith and Dr Emma Woodward, University of Manchester. Part of the Doctor Alan H. Gowenlock PhD Studentship Award.

Despite the discovery of key breast cancer genes like BRCA1 and BRCA2, many families with a strong history of breast and ovarian cancer still receive negative results from standard genetic testing. This project aims to uncover the mechanism of action of cancer-causing mutations in non-coding regions of DNA, areas once considered “junk” but now known to play vital roles in gene regulation.

Our PhD student completed a comprehensive literature review of published BRCA1 variants, in addition to novel variants identified in the clinical laboratory in Manchester, soon to be submitted as a scientific publication. We have screened the promoter of the ATM gene to see if a similar mechanism might occur in other known breast cancer genes, but so far ATM does not seem to have this type of mutation.

The project has also involved working closely with the University’s Genome Editing Unit to develop cell models using CRISPR technology to create a breast tissue derived cell line containing the specific noncoding mutation that will allow us to study previously unexplored mechanisms of inherited breast cancer predisposition.

By identifying hidden mutations that escape standard tests, this research could lead to more accurate genetic screening, earlier diagnosis for high-risk families, and the discovery of new targets for breast cancer prevention and treatment.

Predicting the Impact of Risk-Adapted Screening Using Microsimulation

Project Lead: Dr Elaine Harkness and Professor Sue Astley, University of Manchester.

This project is harnessing the power of microsimulation, a computational tool used to test complex screening strategies, to predict the outcomes of risk-adapted breast cancer screening in the UK. Specifically, the team is focused on women with dense breast tissue, who are at higher risk of developing breast cancer but less likely to benefit from standard mammography alone.

After gaining access to OncoSim-Breast, a leading Canadian microsimulation platform, the team is adapting it for NHS screening scenarios and conducting a detailed literature review to update key parameters. The next steps will involve validating the model with UK screening data, integrating patient and public input, and simulating a range of risk-based screening strategies. The findings will help guide future NHS policy and could significantly improve early detection for women at greatest risk.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 17

Human Breast Tissue Explant Model for Prevention Research

Project Lead: Dr Hannah Harrison, University of Manchester.

Animal models have long dominated preclinical breast cancer research, but they often fail to replicate the complexity of human breast tissue. This project is developing a human tissue explant model as a more accurate, ethical, and personalised alternative for testing breast cancer prevention strategies.

Over the past year, the team has significantly extended the model’s lifespan and refined a multi-colour imaging system to assess changes in tissue structure and response to drugs. They have observed a previously undocumented tissue reaction to oestrogen and successfully tested tamoxifen within the model. The explant system is now contributing to larger studies, including a £600,000 Cancer Research UK-funded project and work on BRCA1-related prevention.

Next steps include validating the model against realworld patient outcomes and testing new preventive agents. This innovative tool could transform how we evaluate prevention strategies, leading to safer, more effective options for women at high risk of developing breast cancer.

Dragon’s Den Projects: Updates

At our Research Conference in September 2024, researchers pitched their ideas in a Dragon’s Denstyle session for the chance to secure up to £10,000 in funding. Five innovative 12-month pilot projects were selected for support, each aiming to advance the prevention or early detection of breast cancer.

Funding was awarded to the first three projects during the 2024–25 financial year. The remaining two projects will receive funding in 2025–26, with work due to begin later this year.

Projects Funded in 2024-25

Empowering Women with Learning Disabilities: Breast Cancer Awareness Workshops

Project Lead: Jenny Jones, Greater Manchester Cancer Alliance.

Women with learning disabilities are significantly less likely to attend breast screening appointments and are more often diagnosed at later stages. This 12-month pilot aims to reduce those inequalities by delivering 10 co-produced, accessible breast cancer awareness workshops across Greater Manchester. Led by Pathways Associates, Manchester not-for-profit Community Interest Companies (CIC) and key community partners, the project will use easy-read resources, interactive teaching and peer involvement to build understanding, reduce stigma, and increase screening confidence. The pilot will involve up to 100 women and create a replicable model for addressing health disparities in cancer prevention.

Following development of an accessible training package, the first workshops began in May 2025, with early sessions revealing a broader need for breast health education, prompting the team to widen the target age group to include women aged 18 and over.

Repurposing Existing Drugs for Breast Cancer Prevention

Project Lead: Dr Hannah Harrison and Anthony Wilby, University of Manchester and the Manchester Breast Centre.

This study explores a faster route to new prevention therapies by testing existing drugs using an advanced breast tissue explant model that accurately reflects the structure and hormonal environment of normal breast tissue. The team will assess compounds targeting metabolic, endocrine, and nerve signalling pathways to identify those that reduce cell proliferation or improve tissue health. By repurposing known drugs, the research could accelerate the discovery of safer, more effective options for high-risk women, while also generating data to support larger-scale studies and personalised prevention strategies.

Targeting Tissue Stiffness: A New Approach to Breast Cancer Prevention

Project Lead: Dr Bruno Simões, University of Manchester and the Manchester Breast Centre

Dense breast tissue, a known risk factor for breast cancer, is linked to increased tissue stiffness, but the biological mechanisms behind this association are still not well understood. This pilot study will use 3D breast organoids grown in soft and stiff collagen

18 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

matrices to mimic the mechanical conditions of dense and less-dense breasts. Researchers will use single-cell RNA sequencing, a technique that lets scientists see which genes are active in individual cells, to examine how matrix stiffness affects gene expression and cell communication, aiming to uncover new biological pathways that could be targeted for prevention, particularly for women with high breast density.

So far, we have successfully established organoid cultures from normal breast samples under soft and stiff matrix conditions and are currently preparing samples for single-cell RNA sequencing data. Preliminary analyses suggest matrix stiffness induces distinct transcriptional responses with potential implications for early transformation pathways.

Projects Funded in 2025-26

National Family History Study Day

Family History Clinics support thousands of women at moderate to high risk of breast cancer, yet services remain fragmented and underrepresented in national prevention research. With the support of Prevent Breast Cancer, the National Breast Imaging Academy, the Association of Breast Surgeons, and Breast Cancer Now, Consultant Breast Surgeon Ramsey Cutress (University of Southampton) is developing a national network of clinics to improve coordination and research participation. A key milestone in this initiative is the Family History Clinic Study Day in early 2026, hosted by Prevent Breast Cancer. Subsidised places will enable geneticists, surgeons, oncologists, and nurses from across the UK to attend, marking a vital step toward more unified, evidence-based care for women with a family history of breast cancer.

Pilot Study: Using Breast Milk in Early Breast Cancer Detection

Project Lead: Dr Niki Flaum, University of Manchester

This pilot project explores the potential of breast milk as a safe, non-invasive tool for detecting early signs of breast cancer in women with a high genetic risk who are pregnant or breastfeeding, groups currently underserved by traditional screening methods. The study will examine whether cancer-associated DNA can be reliably detected in breast milk, assess women’s at udes towards this method, and establish infrastructure for future research, including a participant registry and

biobank. If successful, this novel approach could lead to earlier detection during a critical and currently inaccessible period.

New Research Projects

In December 2024, Prevent Breast Cancer launched its latest funding round, inviting applications for innovative research projects focused on breast cancer prevention across our four research pillars.

At the Trustees Meeting in June 2025, a decision was made to award funding to three exciting new projects, in addition to the Prevent Breast Cancer Research Unit. Full details will be shared in next year’s report but below is a short summary of each project.

Supporting Newly Identified BRCA Carriers Through Prevention

Lead Researcher: Professor Michelle Harvie, University of Manchester and Manchester University NHS Foundation Trust.

This 24-month research project focuses on women who have recently learned they carry a BRCA1 or BRCA2 gene mutation through the NHS Jewish BRCA population testing programme. The project will explore how these women – many of whom are without a known family history – respond to their risk and make decisions about prevention. The findings will inform future clinical guidelines to ensure support and advice are tailored to this growing group.

Preventing Breast Cancer Through Breastfeeding: Identifying Early Genetic Risk Markers

Lead Researcher: Professor James Flanagan, Imperial College London

Using breast milk samples from 300 women, this 12-month study will investigate whether breastfeeding helps clear early cancer causing mutations from the breast. The goal is to improve early risk detection and strengthen the evidence behind breastfeeding as a protective factor.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 19

Improving Equitable Access and Uptake of Breast Cancer Preventative Medications through Telehealth Innovations

Lead Researcher: Professor Juliet Usher-Smith, University of Cambridge

This 16-month pilot study will adapt a successful Australian telehealth model for UK use, offering remote support to women at higher risk. The aim is to increase uptake of preventive medications by removing access barriers and supporting informed decision-making.

Research Plans for 2025-26

The newly funded projects and the Prevent Breast Cancer Research Unit (PBC-RU) will form the foundation of our research strategy for the coming year. Alongside this, we are preparing to reopen our funding round in 2026 to ensure a strong pipeline of new projects for 2026–27.

A major highlight will be the Prevent Breast Cancer Research Conference 2026, which will bring together experts from across the prevention landscape to share knowledge, build partnerships, and inspire innovation.

Research Conference 2026

Prevent Breast Cancer’s Research Conference will return on 3–4 March 2026, taking place at the Treehouse Hotel, Manchester. Building on the success of our 2024 event, the conference will bring together leading researchers, clinicians and advocates to share cuttingedge developments in breast cancer prevention, early detection and risk reduction.

A key feature of the conference will be the return of the Dragons’ Den live grant-making session, offering researchers the chance to pitch their ideas for up to £10,000 in pilot funding. We will also welcome submissions for a Poster Session, providing a platform for emerging findings and fostering peer-to-peer exchange.

The Research Conference continues to play a central role in our strategy, driving collaboration, sparking innovation, and accelerating progress toward a future where breast cancer can be stopped before it starts.

20 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 21

The National Breast Imaging Academy

More mammograms, more research, more lives saved.

In 2025, the UK’s first multidisciplinary breast imaging academy became a reality. Based at The Nightingale Centre in Manchester, the National Breast Imaging Academy is a major milestone in our mission to futureproof breast cancer screening and diagnosis.

Recognising its critical role, Manchester University NHS Foundation Trust and their charity advanced the funds to begin construction in November 2024, while Prevent Breast Cancer continued to fundraise the remaining shortfall. At the time of writing, construction is on track to be completed in November 2025, with the building expected to be fully operational by early 2026. Thanks to the dedication of our team and the generosity of supporters, we reached our fundraising milestone in September 2025.

Meeting Urgent National Need

Breast cancer remains the most common cancer for women in the UK, with nearly 57,000 people diagnosed annually – over 155 each day – and around 11,500 lives lost every year.

Worryingly, incidence rates have risen by 24% over the last 30 years and are expected to rise further. Meanwhile, demand for breast screening is increasing while workforce shortages continue to threaten timely diagnosis. Nationally, nearly 10% of breast radiologist and radiographic posts remain vacant, contributing to long waiting times and even the closure of services in some areas, including three centres in Greater Manchester.

Workforce shortages are expected to grow, with a predicted 40% shortfall in breast radiologists alone by 2028. Without intervention, the NHS risks losing its ability to deliver timely, high-quality breast imaging services.

A Solution Built to Last

The newly built National Breast Imaging Academy, an extension to The Nightingale Centre, is designed to address these challenges head-on. As the UK’s first purpose-built, multidisciplinary breast imaging training centre, the Academy will:

22 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

The Academy is now a powerful hub for screening, diagnosis, training and research. The new facilities allow an additional 13,000 patients to be seen each year for breast screening and significantly expand the UK’s capacity to train and retain the next generation of specialists.

Delivering National Impact

Even before the new building opened, the National Breast Imaging Academy had already made a tangible impact through its online programmes. Since 2019, the Academy has been delivering virtual training and national workforce support, including:

Just as importantly, the Academy benefits the local economy by creating jobs and offering new career pathways in healthcare through apprenticeships and outreach.

But above all, the National Breast Imaging Academy is about saving lives by ensuring that more people receive an early, accurate diagnosis and faster access to potentially life-saving treatment.

With Special Thanks

We are incredibly grateful to every Trust and Foundation that contributed to the National Breast Imaging Academy appeal. Your generosity has helped turn this vision into a reality – one that will save lives for generations to come.

We would like to extend our deepest thanks to those who made especially significant contributions:

Major Supporters

These efforts are already paying off. According to NHS England’s 2023 workforce survey:

These promising figures show that the Academy is already playing a pivotal role in strengthening the UK’s breast imaging workforce and ensuring more people have timely access to high-quality care.

A Cost-Saving and Life-Saving Investment

NHS England has committed £11 million in revenue funding for the Academy over the past six years, including support for staffing and specialist medical equipment. It is also projected that the Academy will save the wider health economy £50 million over the next decade by reducing late diagnoses, streamlining training, and improving workforce retention.

We are also sincerely thankful to the following supporters whose generous donations played a vital role in helping us reach our target:

The Golden Bottle Trust, The Michael Cornish Charitable Trust, Medicash Foundation, The Houghton Dunn Charitable Trust, Lord Leverhulme’s Charitable Trust, Sarah’s Trust, Alliance Family Foundation Limited, The Hospital Saturday Fund, The Hoover Foundation, Jack Livingstone Charitable Trust and Henhurst Charitable Trust.

To all who gave, at every level, thank you for your belief in our mission to prevent breast cancer for future generations and for making this life-saving building possible.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 23

Supporting Patients and Professionals at the Nightingale Centre

Each year, the Nightingale Centre and Prevent Breast Cancer Research Unit welcomes thousands of people through its doors: approximately 18,500 new patients referred by their GP after presenting with symptoms, 13,000 follow-up patients, and 2,600 patients attending the Family History Clinic, many accompanied by their loved ones. The Centre is also home to over 100 NHS staff.

We recognise that attending hospital appointments can be a daunting experience. That is why, as a charity, we have invested in non-clinical spaces within the Centre to make each visit as calming and supportive as possible. Two key features are our coffee bar and gift shop, both of which also play an important role in raising funds and awareness.

Coffee Bar

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Gift Shop

Our on-site and online Gift Shop continues to play a valuable role in supporting our fundraising efforts and engaging patients, visitors and supporters. Offering a thoughtfully curated range of homeware, greeting cards, Christmas cards, and branded products, the shop generates vital income for our work.

This year, nearly 12,400 items were sold across our physical shop, website and at fundraising events, contributing to total sales of £50,007, an increase of 10% on the previous year.

Beyond fundraising, the Gift Shop provides a warm and welcoming space that offers comfort and distraction for those attending appointments, while also helping to raise awareness of our mission to prevent breast cancer for future generations.

The coffee bar continues to be a vital part of the Centre’s welcoming environment. Open weekdays from 9.30am to 4pm, it provides refreshments and comfort to patients, families, and staff alike. In the past year, coffee bar income reached £72,541 marking a 11% increase from the previous year. Beyond financial contribution, it offers visitors a moment of normality in an otherwise anxious time.

24 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

New Merchandise: Our Boob Sketches Collection

In 2024, we proudly launched our Boob Sketches collection - an inspiring range of merchandise designed using hand-drawn illustrations by women affected by breast cancer. The collection features mugs in three colourways, t-shirts and tote bags, each printed with unique sketches that celebrate breasts of all shapes and sizes, alongside a gentle reminder to always check yours.

Breast cancer does not discriminate – it can affect anyone, regardless of gender, age, ethnicity, or background. Our goal is to spark open, everyday conversations about the importance of regular selfchecks, attending screenings, and understanding your family history. Something as simple as chatting over a mug of tea or a compliment about your new t-shirt can be the start of a life-saving conversation.

Every purchase supports our vital research into breast cancer prevention. Whether it is a tote on your shoulder or a mug in your hand, we hope these pieces start conversations and help more people become breast aware.

The boob sketch t-shirts were our highest selling product from April 2024 to April 2025, raising over £2,100 towards our vital work. We plan to build upon this collection and soon will be offering jumpers, pens and water bottles in 2025. Other top selling items were our charity pin badges, Christmas jumpers and everpopular Christmas cards.

Our Amazing Volunteers

At the heart of Prevent Breast Cancer is a dedicated team of volunteers who bring compassion, warmth and a personal touch to everything they do. Many have been personally affected by breast cancer, giving their roles a deep sense of purpose and empathy.

Our Centre-based volunteers play a vital part in the daily life of The Nightingale Centre, They serve coffee with a smile in our cafe, offer kind words at the gift shop and lend a hand in the office, all of which helps transform the Centre into a warm, welcoming place for patients, families and staff. Their consistent presence brings comfort and connection to people facing what can be a difficult and emotional time.

“Volunteering at the Nightingale Centre is one of the most rewarding things I’ve ever done. Whether I’m helping someone find a moment of calm over a cup of coffee or simply offering a friendly face, I feel proud to support such an important cause.”

Jan Langer, Volunteer since 2018

“It’s amazing to know that even small actions can make a big difference to someone’s day.”

Val Hoffman, Volunteer since 2015

Equally vital are our numerous event volunteers and ambassadors, whose energy and enthusiasm help bring our fundraising efforts to life across the year. They represent the charity at a wide range of activities and are instrumental in the success of key campaigns and events, including:

The Christmas Celebration at Manchester Cathedral

Paint Towns Pink and other October Awareness Month initiatives

Bucket collections, bag packing and other fundraising events

We are incredibly proud of each and every single volunteer, many of whom give their time week in, week out. Whether supporting patients in The Nightingale Centre or engaging the public at events, they play a crucial role in driving forward our mission to create a future free from breast cancer.

To all our volunteers: thank you for being the strength behind our mission.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 25

Outreach and Awareness

Each undiagnosed case of breast cancer represents a life potentially saved through early detection. At Prevent Breast Cancer, we are dedicated to ensuring that every individual has the knowledge and resources needed to detect breast cancer as early as possible.

Why Early Detection Matters

Early diagnosis can be the difference between needing a lumpectomy and facing intensive treatments like chemotherapy or radiotherapy. According to NHS data, for every 500 women screened, one life is saved[8] and in 2023-24 alone, nearly 16,700 cases were detected through screening[9] . Awareness of breast cancer signs, symptoms, risk factors, and prevention strategies can be life-saving – and that is exactly why our work matters. All our outreach and awareness activities continue to play a vital role in our mission to prevent breast cancer for future generations, one conversation at a time.

  1. https://breast-screening.uhsm.nhs.uk/home.aspx

  2. https://digital.nhs.uk/data-and-information/publications/statistical/breast-screening-programme/england---2023-24

26 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Highlights from This Year

Health Hour Talks

Between April 2024 and March 2025, we delivered 60 Health Hour talks to schools, workplaces and community groups across the UK, reaching over 2,000 people both in person and online. These sessions offered more than just information; they provided practical, empowering education on breast cancer signs, symptoms, risk factors, the importance of early detection, and the groundbreaking research being led by Prevent Breast Cancer.

Our engaging, conversational approach encourages open dialogue and lasting awareness, helping people feel informed, equipped and motivated to take charge of their breast health.

Feedback from our Health Hour talks has included:

“The content was incredibly informative and equipped attendees with the knowledge and information to help them detect and understand breast cancer in more detail. It was fantastic to see male breast cancer included too.”

“Struck the right tone between being informative but not overloading us all with information.”

Student Challenge and Schools Engagement

Empowering the next generation with knowledge about breast health is a key part of our outreach work. Through our ongoing Student Challenge campaign, we engage young people in schools and sixth form colleges to raise awareness around breast cancer prevention, while encouraging them to become advocates within their own communities.

Our community team regularly visits schools to deliver interactive breast health talks and support students taking part in the challenge. In September 2024, we hosted a School Conference at The Nightingale Centre, offering students the opportunity to tour the facility, learn about the NHS breast screening programme, and hear directly from the researchers and clinicians working at the forefront of breast cancer prevention research.

We are continually inspired by the enthusiasm and commitment of these students, who are not only helping to spread life-saving awareness messages but are also raising vital funds to support our work.

“Many women were moved and inspired by the work that Prevent Breast Cancer does and will now be more vigilant about their breast health.”

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BooBee Bus Awareness Campaign

In November 2024, our iconic pink BooBee Bus Awareness campaign returned to the streets of Greater Manchester – this time with two eye-catching buses and a new partnership. Teaming up with Make 2nds Count, a charity dedicated to supporting women with secondary breast cancer, we jointly delivered an impactful public awareness campaign that highlighted both early detection and the often overlooked realities of secondary breast cancer.

Over the course of two weeks, the BooBee Bus campaign visited a range of high-footfall locations, including supermarkets, shopping centres and Manchester city centre. Supported by our brilliant BooBee ambassadors (women personally affected by breast cancer) the campaign created a powerful talking point to spark meaningful conversations about vital breast health information.

What We Delivered:

Face-to-face conversations about breast awareness, signs and symptoms, and the importance of early detection.

Open dialogue about secondary breast cancer, helping to dispel myths and raise awareness of its signs and challenges.

Peer support and storytelling from BooBee ambassadors, making information more relatable and memorable.

Distribution of breast checking cards, screening information and symptom leaflets which including content focused on secondary breast cancer.

Free, stigma-free engagement in everyday settings, encouraging those who might not otherwise access health information.

“This is a really important campaign that’s driving awareness of the importance of spotting the signs of breast cancer early.”

Marcella M’Rabety, Head of Social Sustainability, Manchester Airports Group

Why It Matters:

For many people, a casual conversation on the street can be the catalyst for attending a screening, seeking medical advice, or learning about a condition they had never heard of. By taking breast health awareness directly to the public (rather than waiting for people to come to clinics) the BooBee Bus campaign continues to remove stigma, build trust, and spark early action.

Thank You

This powerful outreach initiative would not have been possible without the passion and generosity of Patron Margo Cornish, Manchester Airports Group, Smooth Radio, our amazing BooBee ambassadors and our valued campaign partners Make 2nds Count.

28 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Our Community Breast Awareness Hub

Our Community Breast Awareness Hub represents a bold step forward in our mission to reach communities where breast screening uptake is low. This refurbished and branded horsebox has been transformed into a warm and welcoming mobile unit offering free teas, coffees, tote bags and pens to spark conversation and raise awareness about breast health.

Launched in May 2024, the hub travels across Greater Manchester, parking up in neighbourhoods where access and awareness are often limited.

“One of the most exciting parts of my role has been launching our Community Breast Awareness Hub, a reconditioned horsebox turned mobile coffee shop, to bring breast cancer awareness directly into the heart of communities.

Our event at ASDA Longsight was a fantastic celebration of conversation, connection and breast health. Thanks to our multilingual team, we engaged with people from all walks of life, proving that no one is hard to reach when you meet them where they are.”

Azra, Health Inequalities and Community Engagement Officer

From major events like the South Asian Mega Mela to pop-up visits across local communities, we are using this space to encourage meaningful conversations, build trust, and even offer behind-the-scenes tours of mobile screening vans, helping to demystify the screening process and encourage informed decisions about breast health.

Together, we are changing how and where breast cancer awareness happens, bringing support to the people who need it most.

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Health Inequalities

Our awareness campaigns are reaching thousands, but not everyone has the same opportunity to act on what they learn. That is why tackling health inequalities is at the heart of our mission.

We are grateful to Forever Manchester and NHS Charities Together, whose generous grant has supported our efforts to reach underrepresented communities with life-saving breast health information across Greater Manchester. In communities where screening uptake is low and barriers to early diagnosis remain high, we take a more tailored, culturally sensitive approach to ensure no one is left behind.

What are Health Inequalities?

Health inequalities are avoidable, unfair, and systematic differences in health outcomes and experiences between different groups of people. These disparities often stem from factors such as income, ethnicity, education and geography, and they persist because of unequal access to healthcare, variation in quality of care, and broader social and economic inequalities.

In the context of cancer, health inequalities show up as differences in:

Our Commitment

At Prevent Breast Cancer, we believe everyone, regardless of their background, ethnicity or postcode, deserves an equal chance at early diagnosis, treatment, and survival.

While breast cancer does not discriminate, access to awareness, screening and care still does. Women from ethnically diverse and socially deprived communities often face complex barriers to early detection, and the consequences are stark:

These statistics reflect lived realities that cannot be ignored.

  1. Tackling Health Inequalities - Greater Manchester Cancer - https://gmcancer.org.uk/tackling-health-inequalities-2/

  2. https://digital.nhs.uk/data-and-information/publications/statistical/cancer-registration-statistics/england-2020/deaths-from-cancer-increased-with-deprivation?__cf_chl_ tk=YnT3eCIc8TxWBXwjjgsRIi97QJ_ZhFTG.bXtHmJeVWE-1732188218-1.0.1.1-AW.n.u7FIyhv7jVITkVd6UEUwoO1lXJfDIwpziCom2w

  3. https://news.cancerresearchuk.org/2023/01/27/new-analysis-reveals-black-women-in-england-more-likely-to-be-diagnosed-with-late-stage-cancer/

  4. https://breastcancernow.org/support-for-you/breast-cancer-in-ethnic-communities/

  5. https://democracy.manchester.gov.uk/documents/s5444/Thematic%20report%20on%20Cancer%20Prevention%20Treatment%20and%20Care%20in%20Manchester.pdf

30 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Our Approach: Community First

We recognise that addressing health inequalities is not about ticking boxes. It is about building trust, meeting people where they are and truly listening to their concerns. Our Health Inequalities and Community Engagement Team carry out this work with empathy, cultural understanding, and a deep commitment to empowering women.

“Nobody is hard to reach—you just need to know where to look. It’s about more than just leaflets. It’s about listening. It’s about creating safe spaces. It’s about empowering women to put their health first.”

Azra, Health Inequalities and Community Engagement Officer

Key Initiatives:

Targeted Outreach

We deliver breast awareness talks across Greater Manchester in settings ranging from community centres to cultural festivals and women’s groups. Our Health Inequalities Officer tailors each session to the audience, which could mean more of an informal chat or a structured talk with visual tools like synthetic breast models. She also offers sessions in Urdu and Punjabi.

Amplifying Community Voices

From stigma to systemic bias, many women have shared stories of being dismissed or misunderstood when seeking help for symptoms. These conversations are evidence of inequality. Our work ensures these voices are heard, supported and used to shape future services.

Real Stories, Real Impact

During one awareness session, a woman shared that cultural stigma had led her to keep her diagnosis secret, even from her own children. Thanks to our Health Inequalities Officer, she was connected with a Muslim cancer support group, providing her with much-needed emotional support. In another instance, a woman who had decided never to return for screening after a negative experience was gently encouraged to reconsider and decided that she would attend her upcoming appointment.

These stories highlight the power of culturally sensitive outreach and the importance of building trust within communities. They remind us why we must continue to listen, adapt and support women in ways that respect their lived experiences and unique challenges.

Culturally Sensitive Education

We have created multilingual resources and animations that explain what to expect during breast screening. Many women share fears around the procedure, radiation, or past negative experiences. By demystifying the process and offering reassurance, or where possible a tour of the mobile screening units, we help reduce anxiety and build confidence.

Partnerships with Local Leaders

We collaborate with trusted figures and organisations, from faith leaders to cancer support groups, creating safe spaces where women feel seen, heard and valued. This includes joint outreach with experts like Consultant Advanced Nurse Practitioner Lorraine Turner, who can provide on-the-spot answers to clinical questions.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 31

Supporting Inclusive Research and Community Engagement

One of our key focuses this past year has been supporting a community-led research project aimed at improving breast cancer awareness among women from ethnically diverse backgrounds. Our work has included co-producing culturally sensitive materials, facilitating community events, and hosting tailored workshops to share findings in accessible, meaningful ways.

South Asia Gallery Events

In February, we partnered with researchers from the University of Manchester to host two vibrant events at Manchester Museum’s South Asia Gallery. These events celebrated the innovative Tree of Life methodology, an approach that uses storytelling and shared cultural experiences to spark dialogue around breast health and wellbeing. The co-produced digital art installation featured at the events remained on display until May, acting as both a creative expression of the project and a tool for awareness.

The events welcomed over 60 attendees, including representatives from the NHS, local government, academia and grassroots organisations. Significantly, the work received coverage on BBC North West Tonight, where ambassador Roma Das and Prevent Breast Cancer Founder and Honorary President Lester Barr MBE highlighted the urgent need for culturally inclusive breast health campaigns.

Culturally Relevant Intervention Videos

Another central part of this project has been the coproduction of four intervention films tailored to key underrepresented communities. The videos, developed in partnership with creative agency Clear and guided by extensive community consultation, explore breast cancer signs, symptoms, and the importance of screening in a culturally nuanced and accessible way.

Notably, the videos were shaped by focus groups, who influenced both the script and practical details like clothing and language. One film, for example, is delivered in Urdu with English subtitles. The completed videos were shown to participants involved in the research, who responded positively and expressed that they saw their own lived experiences reflected onscreen. Once the research concludes, these films will be used as a vital resource in our outreach toolkit, offering a powerful and lasting way to engage diverse audiences with trusted, relevant messaging.

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Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 33

Health Inequalities Roundtable Meetings 2025

In 2025, Prevent Breast Cancer hosted two pivotal roundtable events designed to address health inequalities in breast cancer prevention and early diagnosis. These events brought together clinicians, researchers, service providers, and grassroots community groups to better understand the complex and often overlapping factors that contribute to unequal outcomes, particularly in under-served communities across Greater Manchester.

We recognised that while many important research projects and outreach initiatives exist in this space, too often they operate in isolation. This lack of coordination results in missed opportunities for collaboration, duplicated efforts, and limited overall impact. Our roundtable series aims to break down these silos by creating shared spaces for open dialogue, learning, and collective action.

Researchers Roundtable, March 2025

We held our first-ever Health Inequalities Roundtable in March, bringing together researchers, healthcare professionals, and patient advocates to explore how research can drive earlier detection and improved outcomes. Using the World Café Method, an inclusive and collaborative discussion format, participants examined three critical themes:

Key insights included the need to build long-term trust with communities, to fairly compensate and engage grassroots groups, and to improve coordination among organisations working in this area. Participants called for a shift from identifying problems to implementing and evaluating practical, impactful solutions.

How to ensure breast cancer campaigns and research projects are culturally inclusive

What prevents women from accessing screening or participating in research

How to translate research into real-world interventions

34 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Community Roundtable, September 2025

Building on insights from the Researchers Roundtable, our Community Roundtable put lived experience at the heart of the discussion, focusing on practical, community-led solutions. Diverse community groups and service providers from across Greater Manchester came together to share knowledge and perspectives. Participants explored the effects of stigma, language barriers, and mistrust of services, while considering how empathy, accessibility, and cultural understanding can improve engagement. Service providers shared information about existing programmes, and community groups reflected on what works well, what should be avoided, and how interventions can be better tailored to local needs.

The Roundtable marked a shift from identifying barriers to driving meaningful change. Participants co-developed seven priority areas for action, including creating culturally sensitive resources, improving healthcare professional education, enhancing the screening experience, reducing duplication through collaboration, and amplifying community voices.

From Conversation to Action

By linking research and community insight, our Roundtables have established a shared foundation for equitable breast cancer prevention and early diagnosis across Greater Manchester.

Insights from both Roundtables are now being translated into a practical roadmap for inclusive engagement.

A detailed Impact Report and infographic from the Researchers Roundtable have been published, with equivalent materials for the Community Roundtable are to follow. Thanks to the passion and commitment of everyone involved, we now have tangible actions and a clear starting point to drive meaningful, lasting change.

We are planning a national stakeholder meeting in 2026, where we will share learnings, assess progress, and work to scale successful strategies that address breast cancer inequalities at a wider level.

The Roundtable series marked a powerful step toward a more collaborative, community-informed approach to breast cancer prevention and early detection. They demonstrated what is possible when lived experience, professional expertise, and grassroots insight come together to drive meaningful change.

With Thanks

Prevent Breast Cancer extends its sincere thanks to all those who participated in the Roundtables. Our thanks also go to Catherine Hennessey for expertly facilitating the discussion and to Inky Thinking for capturing the day so powerfully through illustration.

We are deeply grateful to the Zochonis Charitable Trust and Gilead Sciences for their generous support in making these events possible. Their funding enabled us to host meaningful conversations that are now shaping future action and lasting change.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 35

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We are deeply grateful to every individual, organisation and business who has supported Prevent Breast Cancer this year. Whether through fundraising, donations, volunteering, promotion, research or professional expertise, your contributions are vital to our mission of creating a future free from breast cancer.

Thanks to your dedication, passion and generosity, we have achieved some incredible milestones. Here is a look back at just some of the amazing things you have made possible:

36 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

London Marathon – 21 April

Seven incredible runners, each with a personal connection to breast cancer, raised over £30,000 in the world’s most iconic marathon. Kellie, who carries the BRCA gene, ran alongside her brother Carl. Jessica works at a breast unit in Lancashire, while Arin ran for his mum, a breast cancer survivor. Fiona ran in honour of several family members. Thank you to all our amazing runners for their determination and dedication to fundraising!

Take Me Out Event – 25 April

A group of second-year Event Management students from Manchester Metropolitan University hosted a Take Me Out-themed night at The Bierkeller Manchester. With over 300 students in the audience, the fun and high-energy event raised awareness among young people, whilst raising an incredible £2,100.

Morecambe Bay Walk – 4 May

77 incredible supporters tackled the challenging crossbay route from Arnside to Grange-over-Sands, raising an impressive £10,400.

Paint Sale & Ashton on Mersey Pink – 4-8 May

Organised by our ambassadors and a team of volunteers, this community-wide fundraiser raised £8,500 and helped paint the town pink with awareness.

Tour de Manc – 5 May

With 12 cyclists and a team of volunteers supporting at water stops and the finish line, this Manchesterbased cycling event raised over £14,000, including an additional £5,600 charity donation from Tour de Manc Charitable Foundation. Tour de Manc was also our first horsebox outing!

Danceathon (LCAP fundraising) – 10 May

| 18 members of the Team Empower network and Prevent Breast Cancer CEO danced from midday until midnight | in the basement of Bonded Warehouse in Manchester. Reform Radio sorted the tunes for a 24-hours of nonstop fun, raising around £25,000! |/

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 37

RideLondon – 26 May

Great Manchester Run & Half Marathon – 26 May A total of 41 dedicated supporters took part in the Great Manchester Run and Half Marathon, raising over £25,000. We would like to acknowledge in particular Holly Oldham, Liza Watts, Lucy NooneBlake, and Janice Halliwell, each of whom raised over £1,000.

15 cyclists took part in the bike ride across the capital, motivated by colleagues affected by breast cancer and a drive to support prevention for future generations. Thanks to the support of Barratt Homes and The Mortgage Store, our cyclists raised over £16,000.

Polo & Luxury Holiday Raffle – 2 June

Pink Ladies Day at Bryn Masonic Hall – 2 June

A highlight in the calendar, this fun-filled and inspiring event welcomed 150 women and raised an incredible £10,600, while raising vital awareness in the community. A special thanks go to organisers Chris and Phil Hughes and the Ladies of Bryn Masonic Hall.

We hosted our first-ever Polo event at Cheshire Polo Club’s Wirral Challenge Cup, sponsored by Brewin Dolphin. It was a great opportunity to raise awareness and connect with new supporters. The day also featured a luxury raffle, with a once-in-a-lifetime rail holiday donated by Golden Eagle Luxury Trains. Thanks to generous supporters, the raffle raised £5,500 for our cause. We are incredibly grateful to Brewin Dolphin, Golden Eagle, and everyone who took part.

Lloyd’s of London Abseil – 26–27 June A team of supporters from Hayfin, Kroll, SimCorp and Alliotts took on the exhilarating 289ft Lloyd’s of London abseil, raising an impressive £13,400. The event not only boosted funds but also opened new opportunities for adrenaline-fueled fundraising in London.

Paint Cricket Pink – 21–23 June

Building on its 2023 launch, Paint Cricket Pink returned with even more teams getting involved. Over one weekend, 23 clubs across the Cheshire Cricket League went pink with themed matches, raffles, tuck shops, pink drinks, quiz nights and more, raising over £16,000 to support our work.

38 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

JULY TO ——.. .... = oo SEPTEMBER

Garden Party with Allan and Sally Humphris – 21 July

Long-time supporters Allan and Sally Humphris hosted their annual Garden Party, bringing together friends, family, and local supporters to raise an impressive £3,800. Thankfully the rain held off, and guests enjoyed drinks, BBQ food, and an inspiring update from our Honorary President, Lester Barr, on the Academy and our latest research projects.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 39

Justina Best’s Fundraising Ball – 6 September Long-time supporter Justina’s fabulous ball raised over £7,500!

Great North Run – 7 September

Ten dedicated supporters took part in the Great North Run, the world’s largest half marathon, collectively raising over £9,500 to help fund our vital breast cancer prevention research. We would like to extend our sincere thanks to Katie Crawford, who took part in the event following her breast cancer diagnosis in 2023 and raised an impressive £1,100.

80s Night with Debbie Fricker & Patrick Holden – 14 September

A night of neon, nostalgia and non-stop dancing! Organised by Debbie Fricker and Patrick Holden, this fun-filled 80s-themed evening raised a fantastic £1,800 in support of breast cancer prevention.

The Butterfly Breast Cancer Awards – 20 September

Organised by the incredible Sarah Pickles, this inspiring evening at Vale Royal Abbey celebrated the courage, strength, and resilience of those affected by breast cancer. With emotional stories, uplifting moments, and powerful community spirit, the event raised £4,900 for Prevent Breast Cancer. We were honoured to be chosen as the charity partner for a second year running.

Adrenaline – September

Brave members of the LCAP group took part in 3 hair-raising activities – a Tandem Skydive, zipwire and bungee jump! The challenges contributed just under £8,000 to their fundraising efforts.

40 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

JULY TO SEPTEMBER

Prevent Breast Cancer Research Conference – 24-25 September

We hosted our first-ever Research Conference in Manchester, bringing together leading scientists, clinicians and researchers from across the UK and beyond, to explore the future of breast cancer prevention. The event fostered important conversations around personalised screening, risk prediction and preventative treatment.

Our thanks go to headline sponsors Hologic, TheWell BioScience, Gilead Sciences, and Exact Sciences, as well as Endomag and Berkeley Genetics, for helping make this landmark event possible.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 41

Run for Research Digital Challenge - October

211 participants ran 31 miles over 31 days, raising a recordbreaking £41,900. Two participants commented:

“Seeing everyone pushing themselves and achieving their goals was my favourite thing about Run for Research.”

“I hadn’t run in over 50 years and still managed to raise 47% over my target. It was amazing and inspired me to keep running. We all had our own reasons for taking part.”

Manchester Half Marathon – 13 October Five fantastic runners laced up for breast cancer prevention, raising £5,200 in support of our research.

Breast Services Education Day and Award Ceremony for Manchester University NHS Foundation Trust – 8 November

This was the first event of its kind – a special opportunity for teams from both South and North Manchester to come together and celebrate the tireless work and dedication of everyone involved in the breast service.

This event was particularly special for Prevent Breast Cancer as our Trustee and National Breast Imaging Academy Lead, Dr Mary Wilson, was honoured with a Lifetime Achievement Award in recognition of her outstanding service to the NHS and her tireless championing of women throughout her career.

Christmas Celebration – 20 December

Our much-loved Christmas concert returned for its sixth year, filling the stunning Manchester Cathedral with festive spirit. The evening featured performances from both adult and children’s choirs, as well as a delightful musical nativity performed by local children. It was a joyful celebration for all ages and, thanks to our generous supporters, we raised over £11,300 for Prevent Breast Cancer.

42 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Zumbathon – 1 February

86 energetic participants danced and shimmied their way through our Zumbathon, raising a over £8,000.

March 32 Digital Challenge – March

196 people signed up to walk 32 miles over the month, raising an amazing £49,500. One participant said:

“This challenge helped me get moving again and brought back a sense of positivity. It even gave me the confidence to leave my wig off. I was proud to take part in the hope of preventing others from going through what I have.”

Chris and Roisin’s Ball – 22 February

Our long-time and much loved Ambassadors Chris and Roisin held a ball at Bowdon Rugby Club in Timperley, with a fantastic turnout of family and friends. The evening featured numerous raffle prizes, and both Chris and Roisin delivered heartfelt speeches about why they support breast cancer awareness. The event raised just under £4,000.

Hale Golf Club – Lady Captain’s Charity of the Year – March

Our time as the Lady Captain’s Charity of the Year at Hale Golf Club came to a close in March. Throughout the partnership, the club raised an impressive £8,700 through fundraising events. We are grateful to Gill Kay and Hale Golf Club for their generosity and support in helping to spread awareness across a fantastic community.

Paint Your Nursery or Preschool Pink – February-March

Seven nurseries, preschools, and children’s classes got involved with pink-themed fundraising. From pink toddle-woddles and cake sales to pink games and grandparents open mornings, it was heart-warming to see so many little ones having fun to support our breast cancer prevention research.

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Fundraising Highlights

This year, we have been inspired by the incredible generosity, creativity, and commitment of our supporters. From school students to corporate teams, from pink buses to pasta-making classes, every event, challenge and conversation has helped raise vital funds and amplify our mission: to prevent breast cancer through greater awareness, education and research.

Here are just some of the standout moments that made a big difference in 2024:

The Big Give Christmas Challenge

Our 2024 Big Give Christmas Challenge campaign raised over £148,000 towards building The National Breast Imaging Academy. By unlocking matched funding, every donation was doubled. The campaign showcased the strength of our supporter network and brought us closer to the target of £3.9 million required to complete the build!

The BooBee Campaign

Our bold and brilliant BooBee Campaign returned in 2024, combining community fundraising with high-impact awareness activities. Led by our incredible volunteer ambassadors – the BooBees – this year’s campaign included a wide range of fundraising events, from BooBee Bingo to local challenges, workplace activities, and partnerships across Greater Manchester.

As previously mentioned, a major highlight was the return of our much-loved BooBee Buses, which hit the streets in collaboration with Make 2nds Count to shine a spotlight on both early detection and secondary breast cancer.

With support from the Big Give match funding, the campaign raised an astonishing total of £170,000 ! As well as generating vital funds, the campaign once again brought the message of breast cancer prevention to the heart of communities – making a real difference on every front.

44 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Cath & Ian Ray’s 2024 Challenge

In December 2023, Cath Ray was diagnosed with breast cancer. Determined to make a difference, Cath and her husband Ian set out to raise £20,024 in 2024, with Ian running 2,024 km over the year, joined by family and friends. They surpassed their goal, raising an incredible £20,800 , inspiring countless others along the way.

Bioderma Collaboration

For six months, every Bioderma Sensibio H2O bottle with our Prevent Breast Cancer sticker sold in Superdrug stores nationwide meant that £1 was donated to help fund our vital work, raising just under £5,000 . The campaign helped put breast cancer prevention in front of thousands of shoppers across the country, further reinforcing our role as the UK’s only charity entirely dedicated to the prediction and prevention of breast cancer.

LCAP Group – Empowering Women’s Network

We were honoured to remain the chosen charity for LCAP Empowering Women’s Network, which yet again delivered an outstanding year of fundraising through events including a Danceathon, Adrenaline September (featuring a zip wire, bungee jump and skydive), business networking sessions and a Christmas lunch.

Led by Louise Stephenson and supported by Prevent Breast Cancer’s team, the campaign raised over £56,000 in 2024, part of an extraordinary £150,000+ raised since the partnership began in December 2022. We are proud to partner with such a passionate, values-driven network.

Our Partners

Throughout the year, we have been fortunate to receive ongoing support from a range of corporate partners, including Hayfin, Alliotts, Amet, Circle Health Group, Kroll, SimCorp, and Pixel Inspiration. We are deeply grateful for their commitment and generosity.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 45

Hospitality Helps

Launched by The Tim Bacon Foundation, Hospitality Helps was a new initiative uniting the hospitality sector to support cancer charities. Prevent Breast Cancer was proud to be its first charity partner with funds raised going towards The National Breast Imaging Academy.

Throughout the campaign, venues hosted a variety of activities—bespoke cocktails, ladies’ lunches, charity climbs, and stewardship events—all helping to spread the message of breast cancer prevention to thousands across the UK.

Participating venues included:

San Carlo – Donated £2 from every limited-edition Rosa cocktail

The Alchemist – Added a discretionary £1 to bills during October

Nightcap Group (Dirty Martini, The Cocktail Club, Tonight Josephine, Blame Gloria) – Donated 10% of sales of their rose petal cocktail across UK locations

Gusto – Ladies’ Night in Alderley Edge raised over £5,000

Permanently Unique Group (Tattu & Fenix) – Employees took on the Three Peaks Challenge and raised over £10,000

“Despite a challenging year for the hospitality sector, we saw venues come together to support a vital cause. This campaign shows the power of collective generosity and purpose.”

Jeremy Roberts, Chair, Tim Bacon Foundation

Thanks to generous participation from venues across the UK, the campaign raised over £30,000 , doubled to just over £60,000 thanks to matched funding via The Big Give.

We are incredibly grateful to all the venues involved and to Manchester Hospitality Network for their support in shaping and delivering this impactful campaign.

46 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

The Mammary Walk

On 7 September, Lisa Thomas challenged her colleagues to take on a ‘Mammary Walk’, where 50 NHS Nightingale Centre employees took to the streets of Manchester in inflatable boob costumes to raise funds for the National Breast Imaging Academy, to get more women to their mammograms, sooner.

As well as fundraising, they handed out over 300 breast check cards along the 10km route, spreading breast cancer awareness at the same time! With over £30,000 raised in total, the walkers tripled their fundraising target and moved us one step closer to opening the National Breast Imaging Academy doors.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 47

Paint Towns

Our Paint Your Town Pink campaign continues to grow, with an incredible £59,200 raised across seven towns in 2024–2025. Altrincham, Ashton on Mersey, Bramhall, Cheadle Hulme, Gatley, Macclesfield, and Sale all turned pink in support of Prevent Breast Cancer.

Each town held a variety of pink-themed activities, from party nights and bake sales to fashion shows and sponsored challenges, all designed to bring communities together while raising funds and awareness for our vital work.

Some of the campaign’s highlights included:

Paint Macclesfield Pink

Centred on a lively party night organised by Heather Tebay of Local People Macclesfield and Ambassador Heather Glover, the event raised over £1,000 .

Paint Gatley Pink

Held from 29 September to 6 October 2024, Ambassador Sarah Saphier and her team raised £3,400 , with standout moments including a tribute night to pop icon P!nk at Piccolo Bar & Restaurant, and a local salon Angela Lewis Hair offering ribbon tattoos and pink hair dyeing for donations.

Paint Bramhall and Cheadle Hulme Pink

This month-long effort in October 2024, led by Ambassadors Jo Hoddes, Rachel Peabody, Sally Shrigley and Caroline Tiplady, raised a remarkable £28,000 , featuring highlights such as a bucket collection at Stockport County FC, a meat hamper raffle from J Pimlott Butchers, and a screening of The Rocky Horror Picture Show at The Rex in Wilmslow, hosted by Vanilla Fudge. Local businesses also joined in with pink coffee mornings and a vibrant pink Cheadle Hulme Market.

48 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Paint Altrincham Pink

Taking place from 10–23 March 2025, Altrincham raised an amazing £18,300 . Highlights included the 7th annual Pink Networking Event hosted by South Manchester Business Association, a Pink the Rink match with Manchester Storm Ice Hockey Team, a party night at Toast, pink afternoon teas, and a Spring Fashion Show organised by Altrincham BID.

Paint Sale and Ashton on Mersey Pink

Held from 10–24 May 2025, this was the third consecutive year of the campaign led by Ambassador Angie Hilton and her dedicated team—and it is growing bigger each year! Highlights included a vibrant launch event in Sale town centre, a 5K run/walk in a local park, business-led fundraising activities across the area, and even a pink-themed pub crawl. This fantastic community effort raised an impressive £9,600 .

Pink Afternoon Tea at Ashton Central Mosque

On 1 September, Ashton Central Mosque and Tameside Health Group hosted a warm and welcoming pink afternoon tea, raising an amazing £2,600 . Prevent Breast Cancer’s Health Inequalities and Community Engagement Officer Azra joined the event to speak with guests about the charity’s work and delivered an empowering breast self-examination talk in both English and Urdu, helping raise vital awareness in the community.

Paint Tennis Pink

New for 2025, this campaign was launched by supporter Jane Death and supported by the North East Cheshire Lawn Tennis League. Four clubs (Davenport, Bramhall Lane, Brooklands, and Prestbury) went pink, raising £6,700 through fun, tennis-themed fundraising events.

Thank you for every mile walked, every pound raised, and every story shared. Together, we are creating a future free from breast cancer.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 49

Strategic Aims and Objectives

While our strategic aims were previously set and reviewed on an annual basis, many of our priorities reflect ongoing, long-term ambitions that require sustained focus and collaboration. As such, we are now adopting a three-year strategic outlook to guide our work. This approach recognises that meaningful progress in key areas takes time to implement and embed. The aims and objectives outlined in this report represent a work in progress - a dynamic framework that will continue to evolve as we respond to emerging opportunities, challenges and learning.

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Governance and Structure
Develop a strategy to implement Environmental, Social and Governance reporting and improvement. In Progress
Invest in improving cyber security infrastructure. Ongoing
Work with an independent financial advisor to move employee pensions to a new provider and deliver financial advice
for all staff. Completed
Implement a project management system and CRM database to improve organisational efficiency. In Progress
Implement an updated process to capture information for impact reporting. In Progress
Embed new fundraising and operational staff and utilise the increased resource to improve operational effectiveness
and continue to grow our income generation. Ongoing
Review and update our Grant Terms and Conditions and Cause-Related Marketing Agreements to reflect best practice
In Progress
and maintain strong governance
Establish and implement a formal contract and Terms and Conditions for the Prevent Breast Cancer Research Unit,
ensuring clarity, accountability, and alignment with our governance framework. In Progress
Research
Confirmed for
Organise our 2 [nd] Breast Cancer Prevention Conference. March 2026
Organise a Research Evening for the charity’s supporters with a spotlight on what we have achieved so far and what
still needs to be done. In Progress
Review grant funding policies and processes and update grant application form to make it more user friendly and
In Progress
robust.
Reopen annual grant funding applications and award new research grants. Ongoing
Establish and develop the Prevent Breast Cancer Research Unit as a global Centre of Excellence in the prediction and
prevention of breast cancer, enabling access to data to accelerate research breakthroughs. In Progress
Increase investment in UK-wide research projects focused solely on the prediction and prevention of breast cancer,
strengthening national collaboration and driving forward our vision to stop the disease before it starts. Ongoing
Services to patients and to The Nightingale Centre
Continue to lead on the capital campaign to build the National Breast Imaging Academy. Completed
Recruit new centre volunteers for our coffee bar and shop In Progress
Review suppliers for our coffee bar. Ongoing
Continue to invest in new, ethically sourced merchandise for our shop. Ongoing
Work with North Manchester Breast Centre on plans to open a Prevent Breast Cancer coffee shop in their planned
new build. Ongoing
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50 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

[ Health Awareness and Education

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||| |---|---| |Implement strategies and campaigns developed by the Health Inequalities Team.|Ongoing| |Utilise our unique Community Hub - a converted horse box - to engage the public and raise awareness.|Ongoing| |Develop our library of video content by editing existing videos to provide subtitles in various languages.|In Progress| |Work collaboratively with other local charities, grassroots organisations, and healthcare providers to ensure clear| |communication and networking to encourage breast screening uptake in hardly reached areas.|Ongoing| |Identify research opportunities and collaborate with academics to develop proactive and sustainable interventions that| |address health inequalities.|Ongoing| |Update and enhance education and awareness content delivered through our Health Hour Talks to make sessions| |more engaging and interactive.|In Progress|

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Income Generation

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||| |---|---| |Continue our partnership with Manchester Foundation Trust Charity and achieve our fundraising target of £3.9 million| |to build the National Breast Imaging Academy.|Completed| |Sustain growth and impact achieved from the National Breast Imaging Academy campaign by developing compelling| |research-led funding opportunities and broadening our focus to include unrestricted funding and key charitable areas|Ongoing| |such as health inequalities, outreach, and education events.| |Analyse our supporter database and implement a Moves Management process to increase the number of monthly| |donors and strengthen relationships through improved stewardship.|In Progress| |Continue to develop and grow our Corporate and Major Donor Networks.|Ongoing| |Continue to grow our successful Ambassador programme and build on the success of our Paint Towns Pink campaign.|Ongoing| |Diversify income and increase brand awareness through ongoing digital fundraising and promotional activity – Strategy| |driven by analytics and data.|Ongoing|

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Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 51

Financial Review

This year has seen Prevent Breast Cancer’s income continue to grow, reaching a significant milestone by exceeding £2 million for the first time in the charity’s history. Total income for the year stood at £2,169,572, compared with £1,472,692 in the previous year – a 47% increase. This growth reflects the collective impact of focused fundraising efforts, dedicated supporters, and strategic partnerships.

The primary focus over the past twelve months has been to secure the outstanding funds required to build the National Breast Imaging Academy. This campaign has shaped the overall income profile, with a large proportion allocated to restricted income. In 2024– 2025 alone, over £906,000 was raised specifically for the Academy. Manchester University NHS Foundation Trust and their charity advanced the funds to begin construction in November 2024. At the time of writing, the fundraising target has been met and construction is nearly completed, with the building to be fully operational by early 2026. The capital campaign has also played a key role in expanding our network and unlocking new opportunities, laying a strong foundation for sustainable growth.

In December 2024, the Prevent Breast Cancer Research Funding Round was re-opened, with decisions made in June 2025, marking a return to one of our core charitable objectives: to fund cutting-edge, breast cancer prevention research.

Performance by Income Stream

Trusts and Foundations

This income stream accounted for 27% of overall income, with a remarkable 185% increase compared with the previous year. A generous £250,000 grant from the Garfield Weston Foundation was a standout achievement, and support from other Trusts grew significantly over the year.

Donations and Legacies

Contributions made up 16% of total income, representing a 26% increase year-on-year. Successes include our Big Give Christmas Challenge, which raised vital funds for the Academy, and a major legacy gift of £140,000.

Corporate Fundraising

Corporate partnerships delivered impressive results, with income growing by 101% compared with the previous year. This success is attributed to strong

stewardship of existing relationships and the cultivation of new corporate supporters who have embraced the charity.

Sporting Challenges

Income from this stream was 18% lower than the previous year, as anticipated. This was a strategic decision, with no overseas events planned due to the high cost and recruitment challenges. These events are now run on alternate years to maximise return on investment. Encouragingly, profit exceeded forecast by 36%.

Community and Supporter Fundraising

This area saw a 34% increase in income, thanks to the enthusiasm and creativity of our community.

Despite ongoing operational challenges and the unpredictability of some income streams – particularly those affected by broader economic factors such as the retail environment – Prevent Breast Cancer has performed beyond expectations. All major income streams either grew year-on-year or outperformed forecasts, reflecting the strength of our team, the loyalty of our supporters, and the clarity of our mission.

We offer our heartfelt thanks to our supporters across the UK and internationally who continue to fundraise and support the charity.

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Income Generated
Trusts & Foundations £582,347
Donations & Legacies £353,091
Corporate Fundraising £255,387
Community Activity £241,317
Sport Challenges £230,482
Gift Aid £114,101
Digital Challenges £79,328
Gifts-in-Kind £74,800
Charitable Activity - Coffee Bar £72,541
Investment Income, Bank Interest £57,370
Merchandise £50,077
Conference (Publicising Research) £37,699
Events & Raffle £21,032
Total Income £2,169,572
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52 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Our Expenditure for 2024/25:

How we spend our funds
Charitable Actvites £1,232,274
Cost of Raising Funds £272,171
Merchandise Costs £33,240
Investment Management Fee £6,442
Total Expenditure £1,544,127

Consistent with other years, our charitable activities constitute the vast majority of expenditure, with other costs kept at a minimum. During the year under review, Prevent Breast Cancer spent £1,232,274 on charitable activities. Expenditure included £239,787 from our restricted funds paid to Manchester University NHS Foundation Trust towards the construction of the National Breast Imaging Academy, in accordance with the agreed monthly payment schedule between the two organisations.

At the Prevent Breast Cancer Research Conference in September, our Dragons’ Den initiative awarded over £29,000 to support new research projects and a key educational event. While we continue to fundraise proactively for these initiatives, sufficient reserves are in place to cover the committed expenditure.

A special mention goes to our work addressing health inequalities, supported by the Forever Manchester and NHS Charities Together grants. As outlined on page 30, we have made strong progress with our Health Inequalities work, laying important groundwork for future impact.

As of 31 March 2025, the charity generated a net income of £643,321, reflecting strong performance across income streams and careful cost management. These funds – both restricted and unrestricted – will support planned delivery of charitable activities in the coming year.

There is £1,553,828 held as restricted income and carried forward to 2025-2026 for future charitable expenditure.

The key components of our charitable activities include supporting patients and providing services at The Nightingale Centre, communicating health messages about breast cancer, addressing health inequalities, raising funds to build the National Breast Imaging

Academy, and funding research into prevention. As mentioned previously, the priority for this financial year was to raise the restricted funds required for the Academy. This goal was successfully achieved in September 2025, and the funds will be fully utilised by March 2026. As a result, less was spent on new research during this period, as resources were directed towards this major capital commitment. However, as outlined earlier in this report, we were delighted to award new research funding in June 2025, marking the re-opening of our research programme and a renewed focus on prevention research.

The below charts outline the breakdown of our Charitable Activity for the year 2025/2026 and future charitable expenditure held as restricted reserves.

Breakdown of Charitable Actvity
Outreach and Awareness £449,403
Patent Care and Services to the
Centre		 £298,784
Building the Natonal Breast Imaging
Academy		 £239,787
Addressing Health Inequalites &
Forever Manchester Grant		 £108,148
Publicising and Disseminatng
Research		 £82,647
Research Grants £53,505
Total Expenditure £1,232,274
Future Charitable Expenditure
Restricted Reserves
Natonal Breast Imaging Academy
Capital Build		 £1,167,448
Gene Research PHDs £302,920
Forever Manchester - Addressing
Health Inequalites		 £32,407
Health Inequalites Interventon
Videos		 £21,786
Health Inequalites Research and
Community Roundtables		 £19,113
Addressing Health Inequalites £10,154
Total Restricted Reserves £1,553,828

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 53

Reserves Policy

The Directors and Trustees believe that the charity should hold financial reserves, because it does not receive statutory funding and is entirely dependent on donations from the public and fundraising activities. This is inevitably subject to variation year to year. In addition, it requires the ability to continue operating and honouring grant commitments, should there be falls in income.

Prevent Breast Cancer takes a prudent approach to our finances, maintaining an appropriate level of free reserves to mitigate against the inherent uncertainties of annual fundraising and any significant and unexpected falls in income to ensure core activities can continue.

As of 31 March 2025, the charity holds reserves of £2,313,030 of which £1,553,828 are restricted funds. 75% of restricted reserves will fund the National Breast Imaging Academy, 20% are to fund the Doctor Alan H. Gowenlock PHD Studentship projects, with the remaining 5% reserved for Health Inequalities and Outreach activities.

Designated funds amount to £150,000 which have been allocated to the National Breast Imaging Academy.

The Trustees aim to maintain reserves equivalent to six to nine months of core operational expenditure, to safeguard against a worst-case scenario in which the charity receives no income from its usual sources. This level of reserve ensures that Prevent Breast Cancer can continue to operate and meet its obligations during a period of significant financial disruption.

Core costs include essential staff salaries, office and IT expenses, governance and compliance costs, and other fixed overheads required to sustain day-to-day operations and charitable oversight. The estimated total for six months of core expenditure is £436,179.

Fundraising Costs Policy

The Trustees are committed to ensuring that fundraising costs are proportionate, transparent, and necessary to deliver long-term impact. We value the expertise required to fundraise effectively and are mindful of balancing cost-efficiency with quality. Our aim is to maximise the income available for research and other charitable activities, while investing wisely in the tools and people needed to raise those funds.

The financial statements that follow show that the majority of fundraising expenditure relates to essential activities such as delivering successful fundraising events and campaigns or purchasing stock for trading purposes.

In summary, we raised a total of £2,169,572 from donations and legacies, fundraising events, trading activities, funding from trusts, foundations and investments. We spent £1,232,274 on our charitable activities and research grants, with a further £1,553,828 held in restricted reserves for future charitable expenditure.

Fundraising Approach

During the past year, the charity did not use fundraising agents and did not receive any complaints about our fundraising activities. The charity is a member of the Fundraising Regulator, and the fundraising team follows the Fundraising Regulator’s Code of Practice. We strive always to act ethically and responsibly, using best practice when communicating with our supporters, and we strictly adhere to General Data Protection Regulations (GDPR) and Privacy and Electronic Communications Regulations (PECR) in relation to data use and contacting supporters.

As of 31 March 2025, free reserves total £609,202, excluding designated funds of £150,000 (compared with £599,992 in 2024), equating to over 8 months of core operating costs.

54 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Investment Policy

Prevent Breast Cancer’s investment objective is to invest funds not immediately required in order to produce the best financial return within an acceptable level of risk, with a spread of liquidity to ensure that assets are available to meet cash flow requirements. In accordance with our ethical policy, we ensure our investments do not conflict with our aim of breast cancer prevention.

The charity continues to work with Brewin Dolphin, an experienced firm of investment advisers who manage our investments on a discretionary basis. The investment portfolios are managed in accordance with our Investment Policy.

In 2022 the charity invested a significant percentage of our cash reserves in high interest bank accounts via the Charities Aid Foundation Deposit Scheme, in partnership with Flagstone. This allows us to invest our reserve funds in high interest bank accounts for various periods to ensure the best returns possible over different time periods. Investing a significant part of our reserves in a number of different banks through this scheme also ensures that more of our reserves are protected through the Financial Services Compensation Scheme (FSCS).

The Trustees are satisfied with the investment performance and that it is in line with the investment objective set. Despite ongoing global uncertainty and a challenging economic climate, our investments delivered a modest gain of £17,876 over the year, reflecting a cautious and balanced approach to managing our portfolio. The charity remains confident in the management of its diversified portfolio by Brewin Dolphin and we are optimistic that future performance will continue to improve.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 55

Structure, Governance and Management

Governing Documents

Prevent Breast Cancer is registered as a charitable company limited by guarantee constituted under a Memorandum of Association, and is a registered charity numbered 1109839. The management of the charity is the responsibility of the Directors and Trustees who are elected and co-opted under the terms of the Memorandum and Articles of Association.

Appointment of Trustees and Induction

New Trustees are nominated by Trustee Board members, invited to attend and observe at least two Board meetings and to meet with the Chief Executive, interviewed by a panel of Trustees for that purpose and appointed where they have the necessary skills to contribute to the charity’s strategic leadership and development.

On appointment they receive an induction pack, which comprises a range of information to support them in their new role. This encompasses the charity’s strategy, structure, financial performance and forecast and an overview of a Trustee’s legal obligations. The pack includes governing documents and other relevant documentation available from the Charity Commission e.g., CC3 – The Essential Trustee and CC20 – Charity Fundraising: A Guide to Trustees’ Duties. All new Trustees are introduced to the charity’s staff team.

Organisation

The charity has successfully updated its governing document to reflect the changes implemented following the successful Board Effectiveness Review in December 2022. The updated governing document has been submitted to Companies House and the Charity Commission.

Prevent Breast Cancer has 11 Trustees who meet quarterly to ensure that the charity is fulfilling its charitable objectives and to review the fundraising, trading and finance teams’ performance in raising funds for research into breast cancer prevention. According to the governing document, the maximum number of Trustees can be 13 and the minimum number is five. Each member of the Trustee Board contributes a different area of expertise including ‘academic, medical, commercial, HR and public sector knowledge and experience. Two of the Trustees are Directors of the dormant trading subsidiary. The Chief Executive Officer has been appointed by the Trustees to manage the dayto-day operations of the organisation.

Related Party Transactions

During the year payroll services were provided free of charge by Sheppards Chartered Accountants, a company in which Charles Levine (Trustee until November 2024) is a Director. The estimated value of such services is £2,800 (2024: £2,800) and therefore an equivalent amount has been included within gifts in kind.

All Trustees and the Senior Leadership Team are required to complete a Register of Interest form annually. Any connection between a Trustee and key personnel or organisations is disclosed to the full Board of Trustees in the same way as any other contractual relationship with a related party. The Board adheres to our Conflict of Interest Policy to protect the integrity of Prevent Breast Cancer’s decision-making process, to enable stakeholders to have confidence in the charity’s reliability, and to protect the integrity and reputation of volunteers, staff and Directors.

56 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Pay Policy for Senior Staff

The Board of Trustees and the Senior Management Team comprise the key management personnel of the charity in charge of directing and controlling, running and operating the charity. All Trustees donate their time and do not receive remuneration. Details of related party transactions are disclosed in notes 10 and 26 of the accounts.

The pay of the senior staff is reviewed annually by the People Committee and usually increased in accordance with salary scales set by the Board. Salaries are benchmarked against pay levels in the third sector, taking into account the type of charity, location, annual income and the number of employees.

Risk Management

The Trustee Board is committed to maintaining a strong risk management framework. The aim is to ensure that Prevent Breast Cancer makes every effort to manage risk appropriately by maximising potential opportunities, whilst minimising the adverse effect of risks. Oversight of risk is delegated to the Risk and Compliance Committee, which is comprised of four Trustees and the Head of Operations.

A risk register covering key strategic risks is maintained and reviewed at least twice a year by the Risk and Compliance Committee – more frequently where risks are known to be volatile. A more detailed operational risk register will be maintained in aspects where this is considered appropriate, taking into account of the impact of potential risk and the cost benefit of the exercise.

The charity will continue to regularly review and monitor the effectiveness of its risk management framework and update it as appropriate. In 2024-2025, the Trustees assessed the major risks to which the charity is exposed, in particular those related to the reputation, operations and finances of the charity and were satisfied that systems are in place to manage exposure to the major risks.

The charity receives no statutory funding and is dependent entirely on the donations and fundraising activities of its staff, volunteers and supporters. Therefore, the ratio of income to expenditure is constantly highlighted as a key risk as we need to ensure we can continue to fund our ongoing charitable activities and research projects. The Trustees ensure that this risk is minimised by following the Reserves Policy, outlined on page 54.

The charity’s risk policy is used to support our internal control systems, enabling the charity to respond to operational, strategic and financial risks, regardless of whether they are internally or externally driven. Our risk policy objectives are:

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 57

Reference and Administrative Details

The Trustees, who are also the Directors for the purpose of company law, and who served during the year and up to the date of signature of the financial statements were:

L Barr MBE

P S Glass

D Harris

T Hopla (Re-appointed January 2025)

J Humphris

C Lee-Jones

C J Levine - Treasurer (Resigned in November 2024)

E O’Neal OBE – Chair

S Saleh

M Sellers - Treasurer (Appointed in December 2024)

Dr M Wilson

P Topham

E Wilson (Resigned March 2025)

Key Management Personnel N Barraclough - Chief Executive Officer E Mellor - Head of Communication and Campaigns J Ruth - Head of Income Generation J Coleman-Reed - Head of Operations

Company Registered Number 04831397

Charity Registered Number 1109839 Registered Office Prevent Breast Cancer Research Unit The Nightingale Centre Wythenshawe Hospital Southmoor Road Manchester M23 9LT

58 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Auditors Alliotts LLP Chartered Accountants and Business Advisors Friary Court 13-21 High Street Guildford Surrey GU1 3DL

Bankers Royal Bank of Scotland Plc. 38 Mosley Street Manchester M2 3AZ

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 59

Statement of Trustees’ Responsibilities

The Trustees, who are also the Directors of Prevent Breast Cancer Limited for the purpose of company law, are responsible for preparing the Trustees’ Annual Report and the Financial Statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

Company Law requires the Trustees to prepare financial statements for each financial year which give a true and fair view of the state of affairs of the charity and of the incoming resources and application of resources, including the income and expenditure, of the charitable company for that year.

In preparing these financial statements, the Trustees are required to:

The Trustees are responsible for keeping adequate accounting records that disclose with reasonable accuracy at any time the financial position of the charity and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

In so far as the Trustees are aware:

The Trustees’ Annual Report was approved by the Board of Trustees.

Eamonn O'Neal

Eamonn O'Neal (Dec 2, 2025 13:48:14 GMT)

Eamonn O’Neal - Chairman

Date: 02/12/25

60 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2024 61

Independent Auditor’s Report to the trustees of Prevent Breast Cancer

Opinion

We have audited the financial statements of Prevent Breast Cancer (the ‘charity’) for the year ended 31 March 2025 which comprise the statement of financial activities, the balance sheet, the statement of cash flows and the notes to the financial statements, including a summary of significant accounting policies. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including Financial Reporting Standard 102 The Financial Reporting Standard applicable in the UK and Republic of Ireland (United Kingdom Generally Accepted Accounting Practice).

In our opinion, the financial statements:

Basis for opinion

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the Auditor’s responsibilities for the audit of the financial statements section of our report. We are independent of the charity in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the FRC’s Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Conclusions relating to going concern

In auditing the financial statements, we have concluded that the trustees’ use of the going concern basis of accounting in the preparation of the financial statements is appropriate.

Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the charity’s ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.

Our responsibilities and the responsibilities of the trustees with respect to going concern are described in the relevant sections of this report.

Other information

The other information comprises the information included in the annual report other than the financial statements and our auditor’s report thereon. The trustees are responsible for the other information contained within the annual report. Our opinion on the financial statements does not cover the other information and we do not express any form of assurance conclusion thereon. Our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the course of the audit, or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether this gives rise to a material misstatement in the financial statements themselves. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We have nothing to report in this regard.

62 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Matters on which we are required to report by exception

We have nothing to report in respect of the following matters in relation to which the Charities (Accounts and Reports) Regulations 2008 requires us to report to you if, in our opinion:

Responsibilities of Trustees

As explained more fully in the statement of trustees’ responsibilities, the trustees, who are also the directors of the charity for the purpose of company law, are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as the trustees determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error. In preparing the financial statements, the trustees are responsible for assessing the charity’s ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the trustees either intend to liquidate the charitable company or to cease operations, or have no realistic alternative but to do so.

Auditor’s responsibilities for the audit of the financial statements

We have been appointed as auditor under section 144 of the Charities Act 2011 and report in accordance with the Act and relevant regulations made or having effect thereunder.

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists.

Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.

Irregularities, including fraud, are instances of noncompliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, including fraud, is detailed below.

Extent to which the audit was considered capable of detecting irregularities, including fraud

Our approach to identifying and assessing the risks of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, was as follows:

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 63

We assessed the susceptibility of the charitable company’s financial statements to material misstatement, including obtaining an understanding of how fraud might occur, by:

Audit response to risks identified

To address the risk of fraud through management bias and override of controls, we:

A further description of our responsibilities for the audit of the financial statements is located on the Financial Reporting Council’s website at: http://www. frc.org.uk/auditorsresponsibilities. This description forms part of our auditor’s report.

Use of our report

This report is made solely to the charity’s trustees, as a body, in accordance with Part 4 of the Charities (Accounts and Reports) Regulations 2008. Our audit work has been undertaken so that we might state to the charity’s trustees those matters we are required to state to them in an auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the charity and the charity’s trustees as a body, for our audit work, for this report, or for the opinions we have formed.

In response to the risk of irregularities and noncompliance with laws and regulations, we designed procedures which included, but were not limited to:

There are inherent limitations in our audit procedures described above. The more removed that laws and regulations are from financial transactions, the less likely it is that we would become aware of noncompliance.

Auditing standards also limit the audit procedures required to identify non-compliance with laws and regulations to enquiry of the Trustees and other management and the inspection of regulatory and legal correspondence, if any.

Alliotts

Alliotts (Dec 4, 2025 15:29:48 GMT)

Alliotts

Date: 04/12/25

Chartered Accountants Statutory Auditor 3 London Square Cross Lanes Guildford Surrey GU1 1UJ

Alliotts LLP is eligible for appointment as auditor of the charity by virtue of its eligibility for appointment as auditor of a company under section 1212 of the Companies Act 2006.

Material misstatements that arise due to fraud can be harder to detect than those that arise from error as they may involve deliberate concealment or collusion.

64 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Statement of Financial Activities including income and expenditure account for the year ended 31 March 2025
Notes Unrestricted
funds
2025
£		 Restricted
funds
2025
£		 Total
2025
£		 Unrestricted
funds
2024
£		 Restricted
funds
2024
£		 Total
2024
£
Income from:
Donatons and legacies
3
Charitable actvites
5
Other trading actvites
6
Investments
4
Total income
Expenditure on:
Raising funds
7
Charitable actvites
8
Total expenditure
Net gains/(losses) on
investments
13
Net income/
(expenditure)
Transfers
between funds
Net movement in funds
9
Reconciliaton of funds:
Fund balances at 1 April
2024
Fund balances at 31
March 2025		 802,507
110,240
64,696
57,370
1,034,813
311,853
764,679
1,076,532
17,876
(23,843)
33,053
9,210
749,992
759,202		 1,134,759
-
-
-
1,134,759
-
467,595
467,595
-
667,164
(33,053)
634,111
919,717
1,553,828		 1,937,266
110,240
64,696
57,370
2,169,572
311,853
1,232,274
1,544,127
17,876
643,321
-
643,321
1,669,709
2,313,030		 874,234
65,110
56,346
47,407
1,043,097
294,629
707,201
1,001,830
62,199
103,466
80,807
184,273
565,719
749,992		 429,595
-
-
-
429,595
-
592,180
592,180
-
(162,585)
(80,807)
(243,392)
1,163,109
919,717		 1,303,829
65,110
56,346
47,407
1,472,692
294,629
1,299,381
1,594,010
62,199
(59,119)
-
(59,119)
1,728,828
1,669,709
The statement of fnancial
derive from contnuing ac		 actvites i
tvites.		 ncludes all ga ins and losse s recognised in the year. Al l income and ex penditure

The statement of financial activities includes all gains and losses recognised in the year. All income and expenditure derive from continuing activities.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 65

Balance Sheet as at 31 March 2025

Balance Sheet
as at 31 March 2025		 Balance Sheet
as at 31 March 2025
Notes £ 2025
£		 £ 2024
£
Fixed assets
Tangible assets
Investments
Current assets
Stocks
Debtors
Investments
Cash at bank and in hand
Creditors: amounts falling
due within one year
Net current assets
Total assets less current liabilites
Creditors: amounts falling due afer
more than one year
Net assets
The funds of the charity
Restricted income funds
Unrestricted funds		 16
20
17
18
19
21
22
29
28		 11,963
332,617
903,266
1,452,030
2,699,876
(323,294)		 3,402
1
3,403
2,376,582
2,379,985
(66,955)
2,313,030
1,553,828
759,202
2,313,030		 17,622
81,479
868,830
1,146,324
2,114,255
(300,485)		 4,507
1
4,508
1,813,770
1,818,278
(148,569)
1,669,709
919,717
749,992
1,669,709

66 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

The company is entitled to the exemption from the audit requirement contained in section 477 of the Companies Act 2006, for the year ended 31 March 2025.

The directors acknowledge their responsibilities for complying with the requirements of the Companies Act 2006 with respect to accounting records and the preparation of financial statements.

The members have not required the charitable company to obtain an audit of its financial statements under the requirements of the Companies Act 2006, for the year in question in accordance with section 476.

These financial statements have been prepared in accordance with the provisions applicable to companies subject to the small companies regime.

The financial statements were approved by the trustees on

Eamonn O'Neal

Eamonn O'Neal (Dec 2, 2025 13:48:14 GMT)

E O'Neal - Chairman Chairman

Company registration number 04831397 (England and Wales)

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 67

Notes to the Financial Statements

1. Accounting policies

Charity information

Prevent Breast Cancer is a private company limited by guarantee incorporated in England and Wales. The registered office is The Nightingale Centre, Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT.

1.1 Accounting convention

The accounts have been prepared in accordance with the Companies Act 2006 and “Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102)” (as amended for accounting periods commencing from 1 January 2019). The charity is a Public Benefit Entity as defined by FRS 102.

The financial statements are prepared in sterling, which is the functional currency of the charity. Monetary amounts in these financial statements are rounded to the nearest £.

The financial statements have been prepared under the historical cost convention, modified to include current asset investments at fair value. The principal accounting policies adopted are set out below.

1.2 Going concern

At the time of approving the financial statements, the trustees have a reasonable expectation that the charity has adequate resources to continue in operational existence for the foreseeable future. Thus the trustees continue to adopt the going concern basis of accounting in preparing the financial statements.

1.3 Charitable funds

Unrestricted funds are available for use at the discretion of the trustees in furtherance of their charitable objectives.

Restricted funds are subject to specific conditions by donors or grantors as to how they may be used. The purposes and uses of the restricted funds are set out in the notes to the financial statements.

1.4 Income

Income is recognised when the charity is legally entitled to it after any performance conditions have been met, the amounts can be measured reliably, and it is probable that income will be received.

Cash donations and trading income are recognised on receipt. Other donations are recognised once the charity has been notified of the donation, unless performance conditions require deferral of the amount. Income tax recoverable in relation to donations received under Gift Aid or deeds of covenant is recognised at the time of the donation.

Legacies are recognised on receipt or otherwise if the charity has been notified of an impending distribution, the amount is known, and receipt is expected. If the amount is not known, the legacy is treated as a contingent asset.

1.5 Expenditure

All expenditure is accounted for on an accruals basis and has been included under expense categories that aggregate all costs for allocation to activities. Where costs cannot be directly attributed to particular activities they have been allocated on a basis consistent with the use of the resources.

Fundraising costs are those incurred in generating funds and do not include the costs of disseminating information in support of the charitable activities. Support costs are those costs incurred directly in support of expenditure on the objects of the charity and include project management carried out in house.

Overheads have been allocated on the basis of actual spend by activity.

Grants

Grants payable are charged in the year when the offer is made, except in those cases where the offer is conditional, such grants being recognised as expended resources when the conditions attaching are fulfilled. Grants offered subject to conditions which have not been met at the yearend are treated as designated funds and are not accrued as expended resources.

On occasions funds are raised that relate to specific grants that have been awarded in the

68 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

previous year from unrestricted funds, or for multi-year grants that have been awarded in an earlier year. The funds raised are restricted funds and transfers between funds are made to ensure that the restricted funds are used for their intended purpose.

1.6 Tangible fixed assets

Tangible fixed assets are initially measured at cost and subsequently measured at cost or valuation, net of depreciation and any impairment losses.

Depreciation is recognised so as to write off the cost or valuation of assets less their residual values over their useful lives on the following bases:

Computers 20% straight line

The gain or loss arising on the disposal of an asset is determined as the difference between the sale proceeds and the carrying value of the asset, and is recognised in the statement of financial activities.

1.7 Fixed asset investments

Fixed asset investments are initially measured at cost and subsequently measured at cost less any accumulated impairment losses. The investments are assessed for impairment at each reporting date and any impairment losses or reversals of impairment losses are recognised immediately in net income/(expenditure) for the year.

A subsidiary is an entity controlled by the charity. Control is the power to govern the financial and operating policies of the entity so as to obtain benefits from its activities.

1.8 Impairment of fixed assets

At each reporting end date, the charity reviews the carrying amounts of its tangible assets to determine whether there is any indication that those assets have suffered an impairment loss. If any such indication exists, the recoverable amount of the asset is estimated in order to determine the extent of the impairment loss (if any).

1.9 Stocks

Stocks are stated at the lower of cost and estimated selling price less costs to complete and sell. Cost comprises direct materials and, where applicable, direct labour costs and those overheads that have been incurred in bringing the stocks to their present location and condition. Items held for distribution at no or nominal consideration are measured the lower of replacement cost and cost.

Net realisable value is the estimated selling price less all estimated costs of completion and costs to be incurred in marketing, selling and distribution.

1.10 Cash and cash equivalents

Cash and cash equivalents include cash in hand, deposits held at call with banks, other shortterm liquid investments with original maturities of three months or less, and bank overdrafts. Bank overdrafts are shown within borrowings in current liabilities.

1.11 Financial instruments

The charity has elected to apply the provisions of Section 11 ‘Basic Financial Instruments’ and Section 12 ‘Other Financial Instruments Issues’ of FRS 102 to all of its financial instruments.

Financial instruments are recognised in the charity’s balance sheet when the charity becomes party to the contractual provisions of the instrument.

Financial assets and liabilities are offset, with the net amounts presented in the financial statements, when there is a legally enforceable right to set off the recognised amounts and there is an intention to settle on a net basis or to realise the asset and settle the liability simultaneously.

Basic financial assets

Basic financial assets, which include debtors and cash and bank balances, are initially measured at transaction price including transaction costs and are subsequently carried at amortised cost using the effective interest method unless the arrangement constitutes a financing transaction, where the transaction is measured at the present value of the future receipts discounted at a market rate of interest. Financial assets classified as receivable within one year are not amortised.

Other financial assets

Other financial assets, including investments in equity instruments which are not subsidiaries, associates or joint ventures, are initially measured at fair value, which is normally the transaction price. Such assets are subsequently carried at fair value and the changes in fair value are recognised in net income/(expenditure), except that investments in equity instruments that are not publicly traded and whose fair values cannot be measured reliably are measured at cost less impairment.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 69

Derecognition of financial assets

Financial assets are derecognised only when the contractual rights to the cash flows from the asset expire or are settled, or when the charity transfers the financial asset and substantially all the risks and rewards of ownership to another entity, or if some significant risks and rewards of ownership are retained but control of the asset has transferred to another party that is able to sell the asset in its entirety to an unrelated third party.

1.12 Retirement benefits

Payments to defined contribution retirement benefit schemes are charged as an expense as they fall due.

1.13 Current asset investments

Current asset investments are initially measured at transaction price excluding transaction costs, and are subsequently measured at fair value at each reporting date. Changes in fair value are recognised in net income/(expenditure) for the year. Transaction costs are expensed as incurred.

2. Critical accounting estimates and judgements

Current asset investments

Apart from the investment in the 100% subsidiary dormant trading company, all investment assets at year end are categorised as current asset investments. The trustees have given consideration as to how the investment portfolio is used in the future and believe that the the portfolio is more likely to be utilised/ liquidated within a period of one year.

Premises costs

The charity utilises office space without payment of rent at the Wythenshawe Hospital. The value of this gift in kind is deemed to be nil as the trustees are not able to quantify an appropriate equivalent rent.

70 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Statement of Cash Flows for the year ended 31 March 2025
Notes £ 2025
£		 £ 2024
£
Cash fows from operatng actvites
Cash generated from/(absorbed by)
operatons
Investng actvites
Purchase of tangible fxed assets
Investment income received
Net cash generated from investng
actvites
Net cash used in fnancing actvites
Net increase/(decrease) in cash and
cash equivalents
Cash and cash equivalents at
beginning of year
Cash and cash equivalents at end of
year		 31 -
40,810		 264,896
40,810
-
305,706
1,146,324
1,452,030		 (2,463)
35,017		 (134,357)
32,554
-
(101,803)
1,248,127
1,146,324

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 71

3 Income from donatons
and legacies		 Unrestricted
funds
2025
£		 Restricted
funds
2025
£		 Total
2025
£		 Unrestricted
funds
2024
£		 Restricted
funds
2024
£		 Total
2024
£
Donatons and gifs
Legacies
Donated goods and services		 581,690
146,017
74,800
802,507		 1,134,759
-
-
1,134,759		 1,716,449
146,017
74,800
1,937,266		 647,584
151,850
74,800
874,234		 429,595
-
-
429,595		 1,077,179
151,850
74,800
1,303,829
4
Income from investments		 Unrestricted funds
2025
£		 Unrestricted funds
2024
£
Other income
Interest receivable
5
Income from charitable actvites		 22,869 18,163
34,501
57,370		 29,244
47,407
Unrestricted funds
2025
£		 Unrestricted funds
2024
£
Patent Care and Services to the Centre
Cofee Bar Income
Donatons to the Cofee Bar
Publicising research and results
Research Conference		 71,136 64,657
1,405
37,699
110,240		 453
-
65,110

72 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

6
Income from other trading actvites		 Unrestricted funds
2025
£		 Unrestricted funds
2024
£
Fundraising agents
Merchandise sales
Other trading actvites
7
Expenditure on raising funds		 14,619 11,132
50,077
64,696		 45,214
56,346
Unrestricted funds
2025
£		 Unrestricted funds
2024
£
Fundraising and publicity
Seeking donatons, grants and legacies
Fundraising consultancy
Staf costs
Support costs
Trading costs
Other trading actvites costs
Investment management		 48,225
86,250
116,196		 34,962
115,776
99,178
21,500
272,171
33,240
6,442
311,853		 17,845
267,761
21,095
5,773
294,629

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 73

8 Expenditure on charitable activities

Patent Care
/Nightngale
Centre
2025
£		 Outreach
and
Awareness
2025
£		 Publicising
Research
and
Results
2025
£		 Health
Inequalites
2025
£		 Research
Grants
2025
£		 Forever
Manchester
2025
£		 Natonal
Breast
Imaging
Academy
2025
£		 Total
2025
£
Direct costs
Staf costs
176,189
157,320
Charitable
expenditure
94,654
255,270
270,843
412,590
Grant
funding of
actvites
(see note 11)
-
-
Share of support costs (see note 12)
Support
23,015
30,323
Governance
4,926
6,490
298,784
449,403
Analysis by fund
Unrestricted
funds -
general
188,828
346,456
Restricted
funds
109,956
102,947
298,784
449,403		 37,328
38,549
75,877
-
5,577
1,193
82,647
81,555
1,092
82,647		 43,374
17,542
60,916
-
4,477
958
66,351
52,538
13,813
66,351		 -
-
-
29,480
19,790
4,235
53,505
53,505
-
53,505		 33,869
4,504
38,373
-
2,820
604
41,797
41,797
-
41,797		 -
239,787
239,787
-
-
-
239,787
-
239,787		 448,080
650,306
1,098,386
29,480
86,002
18,406
1,232,274
764,679
467,595
239,787 1,232,274

74 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

8 Expenditure on charitable activities

Previous
year:		 Patent Care
/Nightngale
Centre
2024
£		 Outreach
and
Awareness
2024
£		 Publicising
Research
and Results
2024
£		 Health
Inequalites
2024
£		 Research
Grants
2024
£		 Forever
Manchester
2024
£		 Total
2024
£
Direct costs
Staf costs
161,031
119,292
Charitable
expenditure
490,624
255,206
651,655
374,498
Grant
funding of
actvites
(see note 11)
-
-
Share of support costs (see note 12)
Support
34,762
19,977
Governance
7,252
4,168
693,669
398,643
Analysis by fund
Unrestricted
funds -
general
269,209
380,605
Restricted
funds
424,460
18,038
693,669
398,643		 21,834
16,865
38,699
-
2,064
431
41,194
41,194
-
41,194		 12,055
217
12,272
-
655
137
13,064
792
12,272
13,064		 -
-
-
137,671
7,344
1,532
146,547
9,137
137,410
146,547		 2,459
3,426
5,885
-
314
65
6,264
6,264
-		 316,671
766,338
1,083,009
137,671
65,116
13,585
1,299,381
707,201
592,180
6,264 1,299,381

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 75

9
Net movement in funds		 9
Net movement in funds		 2025
£		 2024
£
The net movement in funds is stated afer charging/(creditng):
Exchange losses
Fees payable for the audit of the charity’s fnancial statements		 12,686
9,950		 7,357
9,444
Depreciaton of owned tangible fxed assets 1,105 656
10 Trustees
None of the trustees (or any persons connected with them) received any remuneraton during the year, Nil
Trustees were reimbursed their travelling expenses (2024 - nil).
10 Trustees
None of the trustees (or any persons connected with them) received any remuneraton during the year, Nil
Trustees were reimbursed their travelling expenses (2024 - nil).
11
Grants payable		 11
Grants payable		 Research grants
2025
£		 Research grants
2024
£
Grants to insttutons:
University of Manchester
Pennine Care NHS Foundaton Trust		 19,480
10,000
29,480		 137,671
-
137,671

76 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

12
Support costs		 Support
costs
£		 Governance
costs
£		 2025
£		 2024
£
Depreciaton
Staf expenses
Staf training
Printng and statonery
IT/website costs
Insurance
Bank and Streamline charges
Legal and professional charges
Other ofce costs
Payroll
Audit fees
Accountancy
Analysed between
Fundraising
Charitable actvites		 1,105
12,686
14,218
4,240
12,403
4,257
26,930
26,770
2,093
2,800
-
-
107,502
21,500
86,002
107,502		 -
-
-
-
-
-
-
3,408
-
-
9,950
9,650
23,008
4,602
18,406
23,008		 1,105
12,686
14,218
4,240
12,403
4,257
26,930
30,178
2,093
2,800
9,950
9,650
130,510
26,102
104,408
130,510		 656
7,357
2,518
3,523
10,735
3,649
21,267
30,206
2,411
2,800
9,444
1,980
96,546
17,844
78,701
96,545

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 77

13
Gains and losses on investments		 Unrestricted funds
2025
£		 Unrestricted funds
2024
£
Gains/(losses) arising on:
Revaluaton of investments
17,876 62,199

14 Employees

The average monthly number of employees during the year was:

Administraton
Operatons
Charitable Actvity
Generatng Funds
Employment costs
Wages and salaries
Social security costs
Other pension costs
The number of employees whose annual remuneraton was £60,000 or more were:
£60,000 - £70,000
Remuneraton of key management personnel
The remuneraton of key management personnel was as follows:
Aggregate compensaton		 2025
Number
2
2		 2024
Number
1
1
8
6
18
2025
£
506,945
45,968
11,363
564,276
2025
Number
1
2025
£
226,120		 6
6
14
2024
£
378,063
29,671
8,115
415,849
2024
Number
1
2024
£
181,794

78 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

15 Taxation

The charity is exempt from taxation on its activities because all its income is applied for charitable purposes.

16 Tangible fxed assets Computers
£
Cost
At 1 April 2024
At 31 March 2025
Depreciaton and impairment
At 1 April 2024
Depreciaton charged in the year
At 31 March 2025
Carrying amount
At 31 March 2025
At 31 March 2024
17 Stocks		 2025
£
5,741
5,741
1,234
1,105
2,339
3,402
4,507
2024
£
Finished goods and goods for resale 11,963 17,622
18 Debtors 2025
£		 2024
£
Amounts falling due within one year:
Trade debtors
Other debtors
Prepayments and accrued income		 5,252
31,560		 18,440
54,991
295,805
332,617		 8,048
81,479

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 79

19
Current asset investments		 2025
£		 2024
£
Listed investments
903,266
Included in current asset investments is £9,551 (2024: £20,796) of cash held within the portolio.		 868,830
20
Fixed asset investments		 Other
investments
£
21
Creditors: amounts falling due within one year
Cost or valuaton
At 1 April 2024 & 31 March 2025
Carrying amount
At 31 March 2025
At 31 March 2024
Other investments comprise:
Notes
Investments in subsidiaries
27		 2025
£
1
1
1
1
2024
£
1
2025
£
2024
£
Other taxaton and social security
Trade creditors
Grants payable
Other creditors
Accruals and deferred income		 12,163
128,296
94,955
5,731		 9,834
56,486
158,112
5,142
82,149
323,294		 70,911
300,485

80 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

22
Creditors: amounts falling due afer more than one year		 22
Creditors: amounts falling due afer more than one year		 2025
£		 2025
£		 2024
£
Trade creditors 66,955 148,569
23
Analysis of net assets between funds		 Unrestricted funds
2025
£		 Restricted funds
2025
£		 Total
2025
£
At 31 March 2024:
Tangible assets
Investments
Current assets/(liabilites)
Long term liabilites
At 31 March 2025:
Tangible assets
Investments
Current assets/(liabilites)
Long term liabilites		 3,402
1
822,754		 -
-
1,553,828		 3,402
1
2,376,582
(66,955)
759,202		 -
1,553,828		 (66,955)
2,313,030
Unrestricted funds
2024
£
4,507
1
894,053		 Restricted funds
2024
£
-
-
919,717		 Total
2024
£
4,507
1
1,813,770
(148,569)
749,992		 -
919,717		 (148,569)
1,669,709

24 Financial commitments, guarantees and contingent liabilities

At year end there is a commitment to the funding of the National Breast Imaging Academy project, with construction having begun at year end. The project is funded by the Manchester Foundation Trust Charity as well as Prevent Breast Cancer. Under legal agreement, the charities are committed to meeting the funding requirements for the project’s completion as at 31 March 2025. It is estimated at year end that the commitment to the project not previously expensed is £1,599,524 (2024: no commitment).

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 81

25
Operatng lease commitments		 2025
£		 2024
£
Lessee
At the reportng end date the charity had outstanding commitments for future minimum
lease payments under non-cancellable operatng leases, which fall due as follows:
Within one year
Between two and fve years		 2,184
3,276
5,460		 2,184
5,460
7,644

During the year invoices to the value of £5,168 (2024: £5,168) were paid to Gunnercooke Solicitors. This firm is considered a related party as Joe Glass (a Partner until 31 March 2025 at Gunnercooke Solicitors) is married to Pam Glass and is also the Company Secretary. No creditor remained outstanding at the year end (2024: Nil).

During the year fee’s of £1,548 (2024: £1,800) were paid to Original Funbags. This company is considered a related party as Tammy Hopla (director of Original Funbags) is also a Trustee of Prevent Breast Cancer. No creditor remained outstanding at the year end (2024: £nil).

During the year payroll services were provided free of charge by Sheppards Chartered Accountants, a company in which Charles Levine is a director. The estimated value of such services is £2,800 (2024: £2,800) and therefore an equivalent amount has been included within gifts in kind. Charles Levine ceased to be a trustee on 26 November 2024. Sheppards continued to process the payroll to 31 March 2025.

27 Subsidiaries

Details of the charity’s subsidiaries at 31 March 2025 are as follows:

% Held
Name of undertaking Registered ofce Nature of business Class of shares held Direct Indirect
Prevent Breast
Cancer Trading England Dormant Ordinary 100.00
Company Limited

82 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

28 Unrestricted funds

The unrestricted funds of the charity comprise the unexpended balances of donations and grants which are not subject to specific conditions by donors and grantors as to how they may be used. These include designated funds which have been set aside out of unrestricted funds by the trustees for specific purposes.

Academy
General funds
Previous year:
Research salaries
Academy
Database & refurbishments
General funds		 At 1 April
2024
£		 Incoming
resources
£		 Resources
expended
£		 Transfers
£		 Gains and
losses
£		 At 31
March 2025
£
150,000
599,992
749,992
At 1 April
2023
£
3,050
150,000
28,992
383,677
565,719		 -
1,034,813
1,034,813
Incoming
resources
£
-
-
-
1,043,097
1,043,097		 -
(1,076,532)
(1,076,532)
Resources
expended
£
(3,050)
-
-
(998,780)
(1,001,830)		 -
33,053
33,053
Transfers
£
-
-
(28,992)
109,799
80,807		 -
17,876
17,876
Gains and
losses
£
-
-
-
62,199
62,199		 150,000
609,202
759,202
At 31
March 2024
£
-
150,000
-
599,992
749,992

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 83

29 Restricted funds

The restricted funds of the charity comprise the unexpended balances of donations and grants held on trust subject to specific conditions by donors as to how they may be used.

AWHA Projects
Forever Manchester and NHS Charites
Together Project
Adressing Health Inequalites
Health Inequalites Roundtable Events
Outreach and Awareness
Building the Natonal Breast Imaging Academy
Gene PHD Legacy
Health Inequalites Videos
Community Hub (Horsebox)
Investgatng The Efects of Preventatve
Tamoxifen
Predictng the Outcomes of Risk-Adapted
Screening (POSSUM)
Alcohol Consumpton and Increased Risk of
Breast Cancer
Investgatng Preventon Using a Human Tissue
Ex-Plant Model
Breast Cancer in Younger Women
Increasing Screening Uptake in
wWomen with Learning Disabilites
Understanding the Role of Matrix Stfness
Educaton Event and Awards		 At 1 April
2024
£		 Incoming
resources
£		 Resources
expended
£		 Transfers
£		 At 31 March
2025
£
16,786
22,494
-
30,002
-
500,345
350,090
-
-
-
-
-
-
-
-
-
-
919,717		 -
51,321
21,585
2,150
24,863
906,890
-
5,000
5,040
33,454
29,332
1,774
12,000
8,350
2,000
10,000
21,000
1,134,759		 -
(41,408)
(774)
(13,039)
(1,092)
(239,787)
(47,170)
-
(6,415)
(33,454)
(29,332)
(1,774)
(12,000)
(8,350)
(2,000)
(10,000)
(21,000)
(467,595)		 (16,786)
-
(10,657)
-
(23,771)
-
-
16,786
1,375
-
-
-
-
-
-
-
-
(33,053)		 -
32,407
10,154
19,113
-
1,167,448
302,920
21,786
-
-
-
-
-
-
-
-
-		 2,000
10,000
21,000		 (2,000)
(10,000)
(21,000)		 -
-
-		 -
-
-
919,717 1,134,759 (467,595) (33,053) 1,553,828

Transfers between funds are made to represent amounts where expenditure for restricted causes has been recognised in unrestricted funds prior to the incoming related resources.

84 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

29 Restricted funds

Previous year:
AWHA Projects
Forever Manchester and NHS Charites
Together Project
Research Salary
Investgatng The Efects of Preventatve
Tamoxifen
Predictng the Outcomes of Risk-Adapted
Screening (POSSUM)
Alcohol Consumpton and Increased Risk of
Breast Cancer
Investgatng Preventon Using a Human Tissue
Ex-Plant Model
Breast Cancer in Younger Women
Addressing Health Inequalites
Outreach and Awareness
Training Suite for Natonal Breast Imaging
Academy
Building the Natonal Breast Imaging Academy
Academy Fundraising Campaign
Genes PHD to be allocated
Search for Hidden BRCA Mutatons PHD		 At 1 April
2023
£		 Incoming
resources
£		 Resources
expended
£		 Transfers
£		 At 31 March
2024
£
16,786
-
-
-
-
-
-
-
10,100
-
411,020
237,703
-
350,090
137,410
1,163,109		 -
28,375
1,000
15,850
400
18,175
21,500
25,980
32,175
10,058
-
262,642
13,440
-
-
429,595		 -
(5,881)
-
-
-
-
-
-
(12,275)
(12,154)
(411,020)
-
(13,440)
-
(137,410)
(592,180)		 -
-
(1,000)
(15,850 )
(400)
(18,175)
(21,500)
(25,980)
2
2,096
-
-
-
-
-
(80,807)		 16,786
22,494
-
-
-
-
-
-
30,002
-
-
500,345
-
350,090
-
919,717

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 85

29. Restricted funds

AWHA projects

The Asian Women’s Health Awareness Campaign will research how to better promote the importance of breast screening to ethnic minority communities from South Asia. This work stream is now part of our Health Inequalities fund and will support the production of videos.

Forever Manchester and NHS Charities Together Project

Two-year grant to support our work in addressing health inequalities. Funding for the hire of a Health Inequalities Officer and to enhance our efforts to improve breast screening uptake among different communities in Manchester.

Investigating the Effects of Preventative Tamoxifen

Research to compare the make-up of breast tissue from women in clinical trials before and after they take preventative drugs, to find markers of whether women are responding or not to the intervention.

Predicting the Outcomes of Risk-Adapted Screening (POSSUM)

This project focuses on enhancing early detection and breast cancer screening through the use of microsimulation—a sophisticated computer programme that analyses data to predict the outcomes of risk-adapted screening.

Alcohol Consumption and Increased Risk of Breast Cancer

Study to investigate the best ways to increase awareness of the link between alcohol and breast cancer risk in middle-aged women.

Investigating Prevention Using a Human Tissue Ex-Plant Model

Researchers will conduct in-depth studies to determine if our ex-plant models maintain key cell types, gene expression, and respond to treatment similarly to matching breast tissue samples from clinical prevention trials. Once fully verified, this lab-based model will provide a platform for testing new prevention treatments for women at high risk of developing breast cancer.

Breast Cancer in Younger Women

This study aims to improve risk estimates for breast cancer in younger women (known as young onset breast cancer, YOBC), for whom cancer is typically more aggressive and has differing risk factors to postmenopausal breast cancer.

Addressing Health Inequalities

Funds to enable the charity to develop its strategy and expand its outreach work and communication campaigns aimed at communities around Greater Manchester where uptake of breast screening is low.

Health Inequalities Roundtable Events

A programme of roundtable meetings for researchers, community groups, and other stakeholders working in this area. This will include the organisation, delivery, facilitation, and reporting of outcomes from these events. The aim is to use the insights to strengthen our strategy and to share findings with researchers and community groups involved in this work. The overall goal is to improve collaboration, prevent duplication of efforts, and support women in accessing the services they need.

Videos to Address Health Inequalities

A co-production project with community representatives and researchers to develop a series of videos that address concerns, answer common questions, and promote the importance of breast awareness and screening among women from South Asian and Black communities.

Outreach and Awareness

Activity (in person and online) which seeks to raise awareness of breast cancer signs, symptoms and risk factors and the importance of breast screening among women.

Community Hub

Converted horsebox, now a mobile branded unit, serves hot drinks and snacks while providing a welcoming space to share important health information with the public. The hub travels to different communities, creating a friendly and approachable environment where women can feel comfortable engaging in conversations, asking questions, and accessing essential information. Funding supports the upkeep, maintenance, storage, insurance, and provisions needed to keep this valuable service running.

Training Suite for National Breast Imaging Academy

Refurbishment of existing space within The Nightingale Centre to create a multi-functional training suite, which will form part of the wider National Breast Imaging Academy programme.

86 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Building the National Breast Imaging Academy (Academy)

A capital project to raise funds to build a National Breast Imaging Academy (Academy), which will be attached to The Nightingale Centre and Prevent Breast Cancer Research Unit in Manchester. More information about this project can be found within the Trustees Report.

Gene PhD Research

Restricted income received from a legacy to create the Doctor Alan H. Gowenlock PhD Studentship award. The funds will enable the Prevent Breast Cancer scientists to continue their research into how the BRCA genes work and why they cause such a dramatic increase in breast cancers.

Increasing screening uptake in women with learning disabilities

This project aims to address disparities by empowering women with learning disabilities through tailored education and personalised support. By providing accessible resources and guidance, we can help ensure that no one is left behind in the fight against breast cancer.

Understanding the role of matrix stiffness

This study aims to understand how matrix stiffness affects normal breast cells and to identify novel biological processes that could be targeted with riskreducing therapies to help lower the risk of breast cancer.

Education Event and Awards

Bringing together breast service team from across Greater Manchester. The event featured high-quality professional development sessions, sharing the latest knowledge, innovations, and best practice. It concluded with an uplifting awards ceremony, celebrating outstanding achievements and recognising individuals who have made a significant contribution to breast services in our region.

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 87

30 Analysis of changes in net funds

The charity had no material debt during the year.

31
Cash generated from/(absorbed by) operatons		 2025
£		 2024
£
Surplus/(defcit) for the year
Adjustments for:
Investment income recognised in statement of fnancial actvites
Fair value gains and losses on investments
Depreciaton and impairment of tangible fxed assets
Movements in working capital:
Decrease in stocks
(Increase) in debtors
(Decrease)/increase in creditors
Cash (absorbed by)/generated from operatons		 643,321
(57,370)
(17,876)
1,105
5,659
(251,138)		 (59,119)
(47,407)
(62,199)
656
5,535
(46,317)
(58,805)
264,896		 74,494
(134,357)

88 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 89

90 Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025

Prevent Breast Cancer - Annual Report and Financial Statements - For the year ended 31 March 2025 91

==> picture [97 x 67] intentionally omitted <==

Prevent Breast Cancer Prevent Breast Cancer Research Unit The Nightingale Centre Wythenshawe Hospital Southmoor Road Manchester M23 9LT

0161 291 4400 info@preventbreastcancer.org.uk www.preventbreastcancer.org.uk

@wearepreventBC

WeArePreventBreastCancer preventbreastcancer

PreventBreastCancer

Prevent Breast Cancer Using Science to Save Lives

Prevent Breast Cancer Registered in England No. 4831397 Registered Charity No. 1109839

Annual Report & Financial Statements 31st March 2025

Final Audit Report

2025-12-04

Created: 2025-12-02 By: Prevent Breast Cancer (marketing@preventbreastcancer.org.uk) Status: Signed Transaction ID: CBJCHBCAABAAep30LkrlXuyrvUnrN3usE4RLlCx70OhI

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