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2022-03-31-accounts

Company number: 04899036

Registered charity number: 1101971 Registered charity number (Scotland): SC043852

AMENDED

ACTION DUCHENNE LIMITED

ANNUAL REPORT AND FINANCIAL STATEMENTS

FOR THE YEAR ENDED 31 MARCH 2022

ACTION DUCHENNE LIMITED

ANNUAL REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

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CONTENTS

Page
Administrative and statutory details 1
Message from the National Director 2 - 5
Report of the Trustees 6 - 11
Independent Auditors’ report 12 - 15
Accounts comprising:
Statement of financial activities 16
Statement of financial position 17
Statement of cashflows 18
Notes to the financial statements 19 - 29

ACTION DUCHENNE LIMITED

ANNUAL REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

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ADMINISTRATIVE AND STATUTORY DETAILS ADMINISTRATIVE AND STATUTORY DETAILS
Board of Trustees Mark Silverman
Gary Fegan
Roger Cockerton (Treasurer)
Dr Tina Flatau
Simon Dadd
Victoria Penrice
National Director Florence Boulton
Scientific Advisory Board Dame Professor K Davies – Chair
Professor M Wood – Vice Chair
Registered office Wellesley House
Duke of Wellington Avenue
Royal Arsenal
London
SE18 6SS
Auditors Simpson Wreford LLP
Wellesley House
Duke of Wellington Avenue
Royal Arsenal
London
SE18 6SS
Company number 04899036
Charity number 1101971
SC043852 (Scotland)
Solicitors Morgan Cole
Bradley Court
Park Place
Cardiff
CF10 3DR
Banks Barclays Bank
PO Box 3
77 North Street,
Keighley
BD21 3SA
The Co-operative Bank Plc
PO Box 250
Skelmersdale
N3 6WT

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ACTION DUCHENNE LIMITED

MESSAGE FROM THE NATIONAL DIRECTOR FOR THE YEAR ENDED 31 MARCH 2022

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Action Duchenne knows it will take a coordinated and sustained national and international effort to fulfil our vision: a world where lives are no longer limited by Duchenne muscular dystrophy.

Rebuild, refocus and reinvest

To achieve this mission and build the capacity for us to deliver support to more individuals and families, 20212022 has been a period of intensive change for Action Duchenne due to COVID pandemic. We have looked carefully at our goals and objectives and at our ways of working. That has involved us considering the capabilities that we need to provide the quality support that our community deserves. 2022 we have:

• focused on delivering meaningful and much-needed support, education and research projects as well as opening our community fundraising and events projects to a wider audience, increasing our support base as well as our platform within the charity landscape; and

Our success in securing funding from the National Lottery has meant that we have been able to begin to deliver our much-needed ‘All-through Support’ programme. The first programme of its type for the Duchenne community, has been designed to provide life-changing support for our community throughout their journey. We have supported over 1,000 vulnerable Duchenne young people, adults and their families. They have received direct help through our ‘All-through Support’ programme. We are proud to play our part in building a future where individuals do not feel isolated or marginalised; where the Duchenne community can come together, share experience and be part of an understanding and inclusive society.

As a result of the positive ripple effect of the ‘All-through’ approach, we are now more engaged with the needs of our community; better connected with other organisations in our area as we compliment and align services; and more confident about how and where Action Duchenne can uniquely act to make a difference. It has been a privilege for the team to learn from other partner organisations on every continent as we have worked on some of the most urgent needs and challenges faced in our community. We have been overwhelmed by kind words and advice from our families, supporters, Trustees, volunteers and partner organisations. We appreciate all the engaged, passionate and thoughtful support we have received.

We value each and every member of our Patrons, ambassadors and Trustees, volunteers and staff, and have truly benefited from their expertise, leadership, compassion, and generosity- we appreciate that you used all of your experience, skills, knowledge and education to move our charity forward. For their ability to see a better world. For being all that they are and doing all that they do.

All-through Support’ programme

Our ‘All-through Support’ programme was launched in October 2021- we want every family receiving this lifechanging diagnosis to be able to immediately access our support network and resources to help them at such a difficult time. Securing funding from HM Government (in partnership with The National Lottery Community Fund, Garfield Weston Foundation and a consortium of corporate partners has meant that we have been able to begin to deliver our vital ‘All-through Support’ programme. In 2021-22 our work included:

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ACTION DUCHENNE LIMITED

MESSAGE FROM THE NATIONAL DIRECTOR FOR THE YEAR ENDED 31 MARCH 2022

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International Conference 2021

The 2021 Action Duchenne International Conference brought together families, clinicians, therapists, researchers and pharmaceutical companies from across the world. Young people, adults and their families living with Duchenne were able to meet each other, gained empowering knowledge and discovered how to live the very best life possible. For clinicians, researchers and academics, our conference provided an unrivalled opportunity to network, discuss the latest research findings and shared expertise in optimal standards of care. Highlights from our conference in 2021:

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ACTION DUCHENNE LIMITED

MESSAGE FROM THE NATIONAL DIRECTOR FOR THE YEAR ENDED 31 MARCH 2022

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Supporting research In 2021-22 our work included:

-completed a multi-year Clinical Trials Lectureship project at Newcastle University which we funded alongside other Duchenne charities. The Clinical Trials Lectureship grant enabled Dr Michela Guglieri to serve as the Clinical Research Team Leader within the John Walton Muscular Dystrophy Research Centre in Newcastle; a key role in one of the UK’s biggest Duchenne muscular dystrophy (DMD) research centres, that ensures trials are run smoothly, safely, and generate high quality data;

-completed our research project in Dr Yung-Yao Lin’s laboratory at Queen Mary University of London. The researchers combined stem cell and gene editing technology, to make a system that allows them to study the junction between nerve and muscle cells in Duchenne, in the laboratory. The system can also test the potential effectiveness of drugs that target this pathway and researchers have already identified one interesting type of potential drug. Together with Barts Charity, we are proud to support this innovative project that aims to develop techniques to combine stem cell and gene-editing technologies in Duchenne; and

to run a clinical trial in the UK.

Living our strategic focus, creating shared value

The recent period we have all experienced has been challenging and unprecedented across the globe. There has been a huge impact on the charity landscape. Our priority in 2021-22 was navigating the disruption caused by COVID and riding out the fundraising difficulties that all charities faced during that time.

Action Duchenne is now focusing on opening our community fundraising to a wider audience, increasing our support base as well as our profile within the charity landscape. Our work relies on voluntary donations from individuals, groups and companies. It is your support that enables us to do what we do.

As well as this, we stayed focused on the long-term future of the charity and we realigned our strategy with all the complexities and challenges entailed in that. We have made huge strides in the last 12 months, further securing the financial viability of the charity while increasing the vital services we offer our community.

Building a strong team united by shared values

This year has been a period of significant change within the team at Action Duchenne. As the organisation has moved forward to realign our objectives around the community’s needs and to fill the support gaps we have identified, our culture and we have adapted our ways of working to enable us to deliver. With new funding in place the charity has turned a new chapter.

4

ACTION DUCHENNE LIMITED

MESSAGE FROM THE NATIONAL DIRECTOR FOR THE YEAR ENDED 31 MARCH 2022

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2021-2022 saw Action Duchenne reset and restructure, bringing in new ideas, new projects and research. It has been great to receive positive feedback from families and supporters - securing funding support from a number of corporates, trusts and foundations who recognised the power of our supporting families work and wished to help us to deliver.

The team here at Action Duchenne had the pleasure of working with 25 (2020-21: 18) regular volunteers giving their time and expertise on a range of tasks, from website, HR support, impact measurement, webinars, writing blogs to researching fundraising opportunities. They have been brought together, to help to secure our financial viability and to initiate crucial support services for our community. Using a robust framework designed to provide life-changing support for our community throughout their journey, we will continue to nurture and grow the culture at Action Duchenne to support our new strategy that puts the community first in everything we do.

Bringing our whole community together

Action Duchenne is the longest serving Duchenne-only charity in the United Kingdom, providing a vital support mechanism for young people, adults and their families at every stage of their Duchenne journey. Creating shared value with our partner organisations has always been fundamental to the way we deliver our work at Action Duchenne. We believe that our charity can only be successful in the long term by creating value for both partner organisations and the community, putting people in the lead so they can help to define and refine our work and our role.

Over the last year, we have been proud to work together with all these amazing organisations and our community, right from the start, in supporting each project. We know we need to continue to improve how all those serving our community come together to provide what is most needed, and we are committed to working with other organisations to further a cohesive shared vision for Duchenne support. Action Duchenne is committed to the fight against the condition and we are taking action - both to support research aimed at creating a future where lives are

no longer limited by Duchenne and to provide tangible and much needed support to the community.

Duchenne muscular dystrophy is a rare genetic condition caused by mutations in the dystrophin gene, which prevents production of a vital muscle protein called dystrophin. The lack of dystrophin makes muscles more susceptible to damage and leads to muscle wasting over time. Duchenne is usually diagnosed around the age of 4, and people living with the condition experience progressive muscle weakness. They typically need to use a powered wheelchair from their early teens, and since the heart and breathing muscles are affected most will require a ventilator in their twenties. Life expectancy is around 30 years. There is no cure. However, with better technology, awareness and improvement in the standard of care we are seeing people with Duchenne living for longer and more fulfilled lives.

…………………………………… Florence Boulton National Director

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ACTION DUCHENNE LIMITED REPORT OF THE TRUSTEES FOR THE YEAR ENDED 31 MARCH 2022

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The Trustees present their report and the financial statements for the twelve months ended 31 March 2022 which have been prepared in accordance with accounting policies set out in the notes to the accounts and comply with the charity’s governing document, the Charities and Trustee Investment (Scotland) Act 2005, the Charities Act 2011, the Companies Act 2006, the Memorandum and Articles of Association and Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).

Reference and administrative details

Action Duchenne Limited is registered under the Companies Act as a company limited by guarantee (company number 04899036). The Charity registration number is 1101971 (England and Wales) and SC043852 (Scotland). The registered office address which is also the principal office address is Wellesley House, Duke of Wellington Avenue, Royal Arsenal, London SE18 6SS.

The governing documents are the Company’s Memorandum and Articles of Association. Each of the members has undertaken to contribute up to £1 in the event of dissolution. The board of Trustees manages the company on behalf of the members and the authority to appoint and remove Trustees is vested in the board.

The following persons were Directors and Trustees during the year:

Mark Silverman

Gary Fegan Dr Tina Flatau Robert Laid – resigned 14/06/2022 Simon Dadd Roger Cockerton (Treasurer) Victoria Penrice Ellen Lambrix – resigned 31/7/2022

The Board have agreed a process of Trustee Training and Induction, so that new and current Trustees are briefed with their legal obligations under charity and company law, the content of the Memorandum and Articles of Association, the committee and decision-making processes, the business plan and recent financial performance of the Charity and any changes therein. This includes the delivery of Charity Commission publications explaining their role.

The Trustees would also like to thank all Patrons and Trustees, past and present, who have given their time and energy to Action Duchenne.

Introduction

In 2021/22 we turned our charity around. We dramatically built up our financial viability while increasing the vital services we offer our community. For the past two years, COVID-19 has meant that our supporting families work has taken place virtually. We have worked tirelessly throughout the pandemic to provide front-line support to our community. The team here at Action Duchenne are putting everything into supporting our Duchenne children, young people, adults and their families, to help them gain empowering knowledge and discovering how to live the very best life possible.

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ACTION DUCHENNE LIMITED

REPORT OF THE TRUSTEES FOR THE YEAR ENDED 31 MARCH 2022

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Our 2021-2024 ‘Rebuild, Refocus and Reinvent’ strategy plan provides a clear roadmap for our future strategy and marks the beginning of a new and exciting chapter. The year ahead looks busy and purposeful for Action Duchenne. We will continue:

Action Duchenne is at the heart of the Duchenne community. We are proud to be collaborating with community leaders to address the unmet needs of the Duchenne community through designing programmes and services to maximise resources.

About us: our vision and objectives

Action Duchenne has a very clear vision: a world where lives are no longer limited by Duchenne muscular dystrophy.

We have three core objectives and are proud to spend 79.1p in every £1 raised on our charitable activities:

While we hope that research and clinical trials will one day lead to a treatment, or cure, for Duchenne, we believe it is vital to support families living with the condition today. We support families from diagnosis through their whole Duchenne journey.

What is Duchenne?

Duchenne muscular dystrophy is a rare, disabling, muscle-wasting condition.

Young people are usually diagnosed around four years old and those living with the condition use a powered wheelchair in their teenage years and most will require a ventilator in their twenties.

Average life expectancy is said to be 30 years. There is no cure. However, with better technology, awareness and improvement in the standards of care we are seeing people with Duchenne living for longer and more fulfilled lives.

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ACTION DUCHENNE LIMITED REPORT OF THE TRUSTEES FOR THE YEAR ENDED 31 MARCH 2022

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Why Action Duchenne?

Our reflection

Action Duchenne is at the heart of the Duchenne community. 50% of our staff and Trustees have a child living with the condition and this provides real, on-the-spot expertise on what the families we support need and the situations they face. We have had some major successes. We brought together the group of scientists who developed the ‘exon skipping’ drugs that offer hope for some living with Duchenne; our disease registry has put the UK at the forefront of clinical trials; our research funding has given more than 130 people the chance to take part in a clinical trial.

Our support team talks to over 2,000 families living with Duchenne every year. We help families to apply for benefits, attend meetings at schools alongside families or simply listen as families talk about their child’s condition. Our work provides a vital lifeline to families, and we aim to help every single person and family affected by the condition. Following diagnosis, parents often say “the only person who understands what I’m going through is another Duchenne parent”.

The team works hard to bring families together, to support each other. We organise the largest Duchenne conference in Europe, bringing families from across the UK together with expert clinicians, researchers, and drug developers. We work with others wherever possible and have acted as a springboard for other patient groups.

Financial review

In 2021/22 the Charity had a net surplus for the year of £202,323 following a surplus of £105,045 in the previous year. The year has been characterised by a challenging environment across the charity sector, we were fortunate enough to see an increase in donations and legacies. Scientific education, research and grants payable decreased by 15.5% from £299,403 to £252,927 which compounded the surplus for the year.

Income was £562,186 in 2021/22 and £472,906 (restated) in 2020/21, with amounts generated from donations and legacies increasing 55.8%, income from other trading activities, decreasing 10.9% and a decrease in income from charitable activities of 5% due to the COVID pandemic.

Expenditure on charitable activities was £284,543 in the year (2021: £326,138), including allocated support costs. This represents 79.1% of total expenditure, compared to 88.7% in the previous year. Of this, £284,543 was spent on charitable activities (2021: £326,138). As well as the research organisations listed above, this includes Eurordis membership, World Duchenne Organisation membership and Genetic Alliance UK membership.

Operational costs continue to be managed tightly, and the National Director has initiated a focused programme of work to correct the fall in charitable income in particular.

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ACTION DUCHENNE LIMITED REPORT OF THE TRUSTEES FOR THE YEAR ENDED 31 MARCH 2022

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Loan borrowings

During the prior year, the Charity secured a £50,000 Bounce Bank loan under the Coronavirus governmentbacked lending scheme. This was interest free for 12 months and no repayments were due during this period. Repayments began from September 2021. In the current year repayments totalling £6,520 were made which included £785 of interest.

Reserves

The Finance Committee, on behalf of the Board of Trustees, monitors the level of unrestricted reserves in the general fund, which is compared to the minimum level of required reserves calculated in accordance with the reserves policy. This is based on three months of charity expenditure of £92,000, which is aimed at providing cover in the event of a sudden reduction in income:

Unrestricted reserves at the end of March 2022 are £420,156, up from £218,073 in March 2021; and restricted reserves are £240 (2021: £Nil - restated). The unrestricted reserves exceed the minimum required under the policy.

Grant making policy

The Charity has a programme of grant making to provide funds for new research towards finding viable treatments and ultimately curing Duchenne muscular dystrophy. Our research strategy sets out five key areas, where we will focus our investment in research going forward:

The rapidly changing developments in international research demand a constant updating of the Charity's grant making policy. Our peer reviews grant applications as part of a two-stage review process and systematically reviews and agrees its research and grant making policy during the development of its annual business plan.

Investment policy

The Charity's assets will be invested in accordance with the Trustee Act 2000 and the trust instrument. Any investments will be managed prudently and in such a way as to provide sufficient income to enable the charity to carry out its purposes effectively both in the short term and over the longer term. In order to spread the level of risk, no single investment or account should exceed 50% of the total funds held by the charity without the agreement of the Finance Committee.

While the Charity’s overall investment policy has been set by the Board of Trustees as a whole, responsibility for ongoing investment matters has been delegated to the Finance Committee.

ACTION DUCHENNE LIMITED REPORT OF THE TRUSTEES FOR THE YEAR ENDED 31 MARCH 2022

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9

Internal control and processes

The systems of internal control, put in place by the Trustees, are designed to provide reasonable but not absolute assurance against material misstatement or loss and include:

The Board of Trustees meet face to face or via remote conferencing at least four times a year. While the Charity aims to involve parents and those living with Duchenne muscular dystrophy as members of the Board of Trustees, a balance is sought by recruiting non-family members who have other scientific, business, and professional expertise. The Board is supported by four committees, each with specific terms of reference: corporate engagement, audit, finance & risk, delivery & research, and conference.

Trustees’ responsibilities

The Trustees (who are also Directors of the charity for the purposes of company law) are responsible for preparing the Trustees’ Annual Report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice).

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ACTION DUCHENNE LIMITED REPORT OF THE TRUSTEES FOR THE YEAR ENDED 31 MARCH 2022

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fair view of the state of affairs of the charitable company and of the incoming resources and application of resources, including the income and expenditure, of the charitable company for that period. In preparing these financial statements, the Trustees are required to:

The Trustees are responsible for keeping proper accounting records that disclose with reasonable accuracy at any time the financial position of the charitable company and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the charitable company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

In so far as the Trustees are aware:

included on the charitable company’s website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions.

Auditor

Simpson Wreford LLP were reappointed as Auditor during the year and have expressed their willingness to continue in that capacity.

The above report has been prepared in accordance with the special provisions of Section 419(2) of the Companies Act 2006 relating to small companies.

Signed on behalf of the Board of Directors.

…………………………………… Roger Cockerton Treasurer

Date: 8 December 2022

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INDEPENDENT AUDITORS’ REPORT

TO THE TRUSTEES OF ACTION DUCHENNE LIMITED FOR THE YEAR ENDED 31 MARCH 2022

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Opinion

We have audited the financial statements of Action Duchenne Limited (the ‘Charitable company’) for the year ended 31 March 2022 which comprise the Statement of Financial Activities, Statement of Financial Position, Cash Flow Statement and the related notes to the financial statements, including a summary of significant accounting policies. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including Financial Reporting Standard 102: The Financial Reporting Standard applicable in the UK and Republic of Ireland (United Kingdom Generally Accepted Accounting Practice).

In our opinion, the financial statements:

Basis for opinion

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the Auditor’s responsibilities for the audit of the financial statements section of our report. We are independent of the Charity in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the FRC’s Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

Conclusions relating to going concern

We have nothing to report in respect of the following matters in relation to which the ISAs (UK) require us to report to you where:

Other information

The Trustees are responsible for the other information. The other information comprises the information included in the annual report other than the financial statements and our auditor’s report thereon. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon.

In connection with our audit of the financial statements, our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether there is a material misstatement in the financial statements or a material misstatement of the other information. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We have nothing to report in this regard.

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INDEPENDENT AUDITORS’ REPORT

TO THE TRUSTEES OF ACTION DUCHENNE LIMITED FOR THE YEAR ENDED 31 MARCH 2022

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Matters on which we are required to report by exception

In the light of the knowledge and understanding of the Charity and its environment obtained in the course of the audit, we have not identified material misstatements in the Trustees’ Annual Report.

We have nothing to report in respect of the following matters in relation to which the Companies Act 2006 requires us to report to you if, in our opinion:

Responsibilities of the Trustees

As explained more fully in the Trustees’ responsibilities statement set out on page 10, the Trustees are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as they determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, the Trustees are responsible for assessing the Charitable company’s ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the Trustees either intend to liquidate the Charity or to cease operations, or have no realistic alternative but to do so.

Our responsibilities for the audit of the financial statements

The Trustees have elected for the financial statements to be audited in accordance with the Charities Act 2011 rather than the Companies Act 2006. Accordingly, we have been appointed as auditor under section 144 of the Charities Act 2011 and report in accordance with regulations made under section 154 of that Act.

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditors’ report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements. A further description of our responsibilities for the audit of the financial statements is located on the Financial Reporting Council’s website at: [www.frc.org.uk/auditorsresponsibilities]. This description forms part of our auditor’s report.

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INDEPENDENT AUDITORS’ REPORT

TO THE TRUSTEES OF ACTION DUCHENNE LIMITED FOR THE YEAR ENDED 31 MARCH 2022

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Extent to which the audit was considered capable of detecting irregularities, including fraud

Audit response to risks identified

We assessed the susceptibility of the Charitable company’s financial statements to material misstatement, including obtaining an understanding of how fraud might occur, by:

To address the risk of fraud through management bias and override of controls, we:

In response to the risk of irregularities and non-compliance with laws and regulations, we designed procedures which included, but were not limited to:

There are inherent limitations in our audit procedures described above. The more removed that laws and regulations are from financial transactions, the less likely it is that we would become aware of noncompliance. Auditing standards also limit the audit procedures required to identify non-compliance with laws and regulations to enquiry of the directors and other management and the inspection of regulatory and legal correspondence, if any.

Material misstatements that arise due to fraud can be harder to detect than those that arise from error as they may involve deliberate concealment or collusion.

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INDEPENDENT AUDITORS’ REPORT TO THE TRUSTEES OF ACTION DUCHENNE LIMITED FOR THE YEAR ENDED 31 MARCH 2022

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Use of our report

This report is made solely to the Charitable company’s members, as a body, in accordance with Chapter 4 of the Charities (Accounts and Reports) Regulations 2008. Our audit work has been undertaken so that we might state to the Charitable company’s members those matters we are required to state to them in an auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Charitable company’s members as a body, for our audit work, for this report, or for the opinions we have formed.

Michael Broder, Senior Statutory Auditor

For and on behalf of Simpson Wreford LLP, Statutory Auditor

Wellesley House

Duke of Wellington Avenue

Royal Arsenal

London

SE18 6SS

Dated: 8 December 2022

Simpson Wreford LLP is eligible to act as an auditor in terms of section 1212 of the Companies Act 2006.

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ACTION DUCHENNE LIMITED

STATEMENT OF FINANCIAL ACTIVITIES (including statement of income and expenditure) FOR THE YEAR ENDED 31 MARCH 2022

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2022
2022
Unresticted
Restricted
Notes
funds
funds
Income and endowments from: 4
Donations and legacies
207,192
139,968
Charitable activities
3,534
95,426
Other trading activities
114,797
-
Investments
19
-
Other - Government grants
1,250
-
Total income
326,792
235,394

Expenditure on:
17
Raising funds:
Cost of events and general fundraising
75,320
-
Charitable activities:
Scientific education
15,671
63,369
Research, supporting families,
and grants payable
2,471
171,416

Improved management and
medical care
31,616
-

Total expenditure
125,078
234,785

Net income/(expenditure)
201,714
609

Transfers between funds
369
(369)
Net movement in funds
202,083
240
Reconciliation of funds:
Balance at 1 April 2021
218,073
-
Balance at 31 March 2022
420,156
240
2022
2021
Total Total
funds
funds
Restated
347,160
222,844
98,960
104,128
114,797
128,874
19
32
1,250
17,028
562,186
472,906
75,320
41,723
79,040
16,041
173,887
299,403
31,616
10,694
359,863
367,861
202,323
105,045
-
-
202,323
105,045
218,073
113,028
420,396
218,073

The notes on pages 19 to 29 form part of these financial statements.

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ACTION DUCHENNE LIMITED

STATEMENT OF FINANCIAL POSITION AS AT 31 MATCH 2022

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Notes
Fixed assets
Tangible assets
5
Investments
6
Current assets
Debtors
7
Cash at bank and in hand
Current liabilities
Creditors due within one year
8

Net current assets
Total assets less current liabilities
Creditors due more than one year 9
Net assets
15
Represented by:
Restricted funds
13
Unrestricted funds
14
2022
£
£
2,881
2
2,883
11,049
475,928
486,977
(35,222)
451,755
454,638
(34,242)
420,396
240
420,156
420,396
2021
Restated
£
£
1,920
2
1,922
29,661
396,747
426,408
(166,090)
260,318
262,240
(44,167)
218,073
-
218,073
218,073

The company is entitled to the exemption from the audit requirement contained in section 477 of the Companies Act 2006, for the period ended 31 March 2022. No member of the company has deposited a notice, pursuant to section 476, requiring an audit of these accounts under the requirements of the Companies Act 2006.

The directors acknowledge their responsibilities for complying with the requirements of the Companies Act 2006 with respect to accounting records and the preparation of financial statements.

These accounts have been prepared in accordance with the provisions applicable to company’s subject to the small companies’ regime.

The financial statements on pages 16 - 29 were approved by the Trustees on 8 December 2022 and signed on their behalf by:

…………………………………… Roger Cockerton– Trustee/Treasurer

Registered charity number – 1101971 Registered charity – SC043852 (Scotland)

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ACTION DUCHENNE LIMITED

STATEMENT OF CASH FLOWS FOR THE YEAR ENDED 31 MARCH 2022

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Notes
Cashflows from operating activities:
Net cash provided by operating activities
19

Cashflows from investing activities:
Dividends, interest, and rents from investments
Purchase of equipment
Proceeds from disposal of tangibles
Net cash (used in) by investing activites
Cashflows from financing activities:
Loan received
Loan repayment
Net cash (used in)/provided by financing activites

Change in cash and cash equivalents in the reporting period
Cash and cash equivalents as at 1 April 2021
20
Cash and cash equivalents as at 31 March 2022
20
2022
Total
£
88,454
19
(2,772)
-
(2,753)
-
(6,520)
(6,520)
79,181
396,747

475,928
2021
Total
£
249,765
33
(1,425)
-
(1,392)
50,000
-
50,000
298,373
98,374
396,747

18

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

1. Accounting policies

Action Duchenne Limited meets the definition of a public benefit entity under FRS102. Assets and liabilities are initially recognised at historical cost or transaction value unless otherwise stated in the relevant accounting policy note(s).

The financial statements are prepared in sterling, which is the functional currency of the company. Monetary amounts in the financial statements are rounded to the nearest £.

The financial statements have been prepared under the historical cost convention, modified to include the revaluation long-term leasehold property and certain financial instruments at fair value or amortised cost. The principal accounting policies are set out below.

The effects of events relating to the twelve months ended 31 March 2022 which occurred before the date of approval of the financial statements by the Trustees has been included in the financial statements to the extent required to show a true and fair view of the state of affairs as at 31 March 2022 and the results for the year ended on that date.

19

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

_____________

1. Accounting policies (continued)

Grants payable are payments made to third parties in the furtherance of the Charity’s objectives. Single or multi-year grants are recognised as resources expended when a grant commitment is made without condition, or when the condition will not in practice allow the Charity to avoid the liability.

Performance related grants are charged to SOFA as performance conditions are met.

20

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

1. Accounting policies (continued)

Restricted funds made to the charity are to be used in accordance with specific restrictions imposed by donors. The cost of raising and administering such funds are charged against the specific fund. The aim and use of each restricted fund is set out in the notes to the financial statements.

2. Employees

Costs to the company were as follows:

Gross wages:
- projects

- non-projects
Staff pension
Employer’s NI contributions
2022
£
187,551
18,169
7,013
14,826
227,559
2021
£
169,635
20,498
4,123
14,315
208,571

The defined contribution expense is allocated between restricted and unrestricted funds in accordance with the allocation of wages and salaries costs.

There were no employees at Action Duchenne Limited whose remuneration exceeded £60,000.

During the year redundancy payments totalling £8,261 (2021: £Nil) were made to employees.

The average number of full-time employees during the year was 8 (2021: 6) analysed as follows:



Management - FTE
Research - FTE
Supporting families - FTE
Fundraising - FTE
Advocacy/Campaigns - FTE
3. Net incoming resources is stated after charging

Auditors’ fees
Independent examination and accountancy fees
Depreciation
2022

Number

1.0
1.0
4.0
1.2
0.8
8.0
2022

£

6,500
8,253
960
2021
Number
0.6
0.6
2.3
1.8
0.7
6.0
2021
£
-
7,620
640

21

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

4. Analysis of income and endowments

Unresticted Restricted Restricted 2022 2021
funds funds Total Total - Restated
£ £ £ £
Donations and legacies
- Grants of a general nature - 139,968 139,968 18,551
- Membership subscriptions 41,217 - 41,217 41,711
- Fundraising income 145,966 - 145,966 104,688
- Gift Aid 13,831 - 13,831 7,894
- Other 6,178 - 6,178 50,000
Charitable activities
- Performance related grants 3,534 95,426 98,960 104,128
- Other - - - -
Other trading activities
- Fundraising events - - - 4,375
- Non-charitable trading activities 114,594 - 114,594 123,066
- Shop income 203 - 203 1,433
Investments 19 - 19 32
Other – Government grants 1,250 - 1,250 17,028
326,792 235,394 562,186 472,906
Tangible assets
Computer Fixtures Office
equipment & fittings equipment Total
£ £ £ £
Cost
At 1 April 2021 25,147 1,098 8,264 34,509
Additions 2,772 - - 2,772
Disposals (25,147) (1,098) (6,839) (33,084)
31 March 2022 2,772 - 1,425 4,197
Depreciation
At 1 April 2021 24,407 1,087 7,095 32,589
Charge fpr the year 693 - 267 960
Disposals (24,407) (1,087) (6,739) (32,233)
At 31 March 2022 693 - 623 1,316
Net book value
At 31 March 2022 2,079 - 802 2,881
At 31 March 2021 740 11 1,169 1,920

5. Tangible assets

22

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

6. Investments




Programme related investments
Convertible loan note in Halo Therapeutics LLC
Less: treated as grant paid 2012
2022
£
225,000
(224,999)

1
2021
£
225,000
(224,999)
1

Halo Therapeutics is a clinical-stage biopharmaceutical firm focused on developing innovative therapies for rare fibrotic diseases such a Duchenne Muscular Dystrophy. The programme has now merged with DART to ensure IP protection in anticipation of FDA approval. 2014 saw an application being made to the US regulatory body that included nonclinical study reports, pharmacokinetics, human safety and biomarker data from the DMD clinical program, and a comprehensive analysis and summary of the year’s activity.

There has been no communication from Halo Therapeutics regarding additional financing arrangements. The Trustees are therefore unable to consider the fair value of this holding and it should remain valued at cost.


Other investments
1,371 Ordinary shares of £0.001
2022
£
1
2021
£
1

PepGen Limited (company number 11170794) is a company focused on biotech research and development, to improve the delivery and effectiveness of exon skipping drugs as a way of restoring dystrophin. In April 2018, Action Duchenne was donated a number of shares in the company in recognition of previous support and funding to the University of Oxford, which amounted to a grant of £48,000 in April 2017.

In December 2020 PepGen Limited participated in a $45m Series A funding round led by RA Capital Management with an exchange of shares originally denominated in Sterling to US Dollars in PepGen Inc.

In August 2021 PepGen Limited announced an IPO closing of $112.5m crossover financing to advance transformative therapies for neuromuscular diseases that resulted in an increase in our shareholding originally 1,371 to 13,467. The shares are listed on NASDAQ with a value of c$9 giving an overall value to our holding of $121,203. However, there is a restriction as to when shares can be sold.

In view of the high-risk nature of this type of investment the Board has decided not to recognise the value of this holding until a decision is reached whether to keep the shares once permitted to sell them.

23

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

7. Debtors


Trade debtors
Other debtors
Prepayments
2022
2021
Restated
£
£
3,500
21,426
3,364
4,441
4,185
3,794
11,049
29,661

8. Creditors: amounts falling due within one year



Trade creditors
Accruals and deferred income
Bank loan
Other creditors

2022

£

210
22,060
10,022
2,930
35,222
2021
£
21,426
137,426
5,833
1,405

166,090

Deferred income included above relates to donations totalling £2,858 (2021: £Nil), and grant income related to the following projects: Lottery All Through Support £10,476 (2021: £Nil); Supporting Families (formerly Science on Tour) £Nil (2021: £90,000); and Demelza project sponsorship of £Nil (2021: £15,000). Donation income is deferred when it relates to a specific event taking place in the following period. Grant income is deferred until the Charity incurs eligible expenditure on the project.

9. Creditors : amounts falling due after more than one year



Bank loans and overdrafts
2022
£
34,242
2021
£
44,167

10.Trustees’ expenses and indemnity insurance

A Trustee may receive reimbursement of reasonable out-of-pocket expenses actually incurred in running the charity. In 2022, the total out-of-pocket expenses reimbursed was £3 to one Trustee (2021: £Nil) for travel and accommodation.

No indemnity insurance was paid by the company on behalf of the Trustees.

No Trustees received any remuneration from the Charity during the year.

24

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

_____________

11. Control relationships

The company is limited by guarantee with the liability of the members limited to £1 each in the event of a winding up. Consequently, no Trustee or group of Trustees has overall control of the company.

12. Other professional services provided by the auditor

In common with many other businesses of our size and nature, we use our auditors to assist with the preparation of the financial statements.

13. Restricted funds

The Charity has a number of restricted funds which are for future use.

The movements for the year are as follows:

At 1 April Incoming Outgoing Transfers At 31 March
2021 - Restated Resources Resources 2022
£ £ £ £ £
Restricted funds:
National Lottery Fund
-
95,426 (95,426) - -
Supporting Families - 115,000 (114,760) - 240
Contact a Family - 9,968 (9,968) - -
Demelza - 15,000 (14,631) (369) -
- 235,394 (234,785) (369) 240

Details of funds

National Lottery Fund – A grant of £480,130 was awarded from HM Government (in partnership with the National Lottery Community Fund) over two years to support the ‘All-through Support’ programme, the first of its type for the Duchenne community. The project was launched in October 2021. The aim is for every family receiving this life-changing diagnosis to be able to immediately access a support network and resources to help them at such a difficult time. The project is expected to be completed in 2023/24.

Supporting Families Through Diagnosis and Impossible Decisions (formerly known as Science on Tour) – supported by the Garfield Weston Foundation and a consortia of pharmaceutical companies. The first year of this project was completed in March 2022. Funding has been secured to support the delivery of the second year of activities in 2022/23.

Contact a Family – this project has helped to establish peer-to-peer support groups where Duchenne parents, grandparents, siblings and those living with the condition come together to share experiences and support each other. These groups continue to thrive, topics being discussed are returning to school, anxiety, mobility decline and loneliness. These groups are vital and offer a safe space for our community. The project was completed in January 2022.

Demelza – this project has developed joint working between Demelza House Children's Hospice and Action Duchenne to support young people and their families. Reviews to be carried out to collect information and data to help decide how to improve the support for young people living with Duchenne and their families who are going through the transition process. The project was completed in November 2021.

25

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

14. Unrestricted funds



At 1 April 2021 - Restated

Income
Expenditure

Transfer

At 31 March 2022
General
Fund
£
218,073
326,792
(125,078)
369
420,156

The General Fund – Funds allocated to pursue the Charity’s aim of finding a cure for Duchenne, bring new medicines for Duchenne to the market and to enable us to continue to campaign for greater standards of care for those with Duchenne.

15. Analysis of net assets between funds

Unrestricted
Restricted
funds
funds
£
£
Fixed assets
2,883
-
Current assets
476,261
10,716
Current liabilities
(24,746)
(10,476)
Non-current liabilities
(34,242)
-
420,156
240
2022
2021
Total
Total
£
£
2,883
1,922
486,977
426,408
(35,222)
(166,090)
(34,242)
(44,167)
420,396
218,073

16. Fund Transfers

In the prior year, there was a transfer of £420 from unrestricted funds to the Demelza restricted fund. This was due to a timing difference between set up-costs and the quarterly allocation of incoming resources. As a result, in the current year there was a balance of £369 remaining on the Demelza fund and as such a transfer has been made from restricted funds back to unrestricted funds. This equates to a net overspend of £51 on the Demelza project.

26

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

17. Analysis of resources expended

Support costs:
Bank charges and interest
Insurance
Wages and salaries
Printing, postage and stationery
Training, recruitment and other staff costs
Rent and rates
Computer costs
Storage
Telephone and internet costs
Depreciation
Loss on disposal of tangibles
Trustees’ meetings
Governance costs
Professional fees
Miscellaneous expenditure
2022
£
4,847
1,020
227,559
7,251
23,687
240
12,029
2,501
2,559
960
851
3
14,753
13,834
4,065
316,159
2021
£
1,216
1,612
208,571
7,380
3,371
6,026
10,403
2,201
2,292
640
-
-
15,650
6,188
1,800
267,350

Grants totalling £46,746 were payable to 3 medical research institutions, as described in note 18. These were accrued in the prior year financial statements.

Support and governance costs are allocated as follows:

Support and
governance

£
Research, supporting families, and
grants payable 55%
173,887
Fundraising and events 10%
31,616
Scientific education 25%
79,040
Improved management and medical care 10%
31,616
316,159
Direct
costs
£
-
43,704
-
-
43,704
Total
£
173,887
75,320
79,040
31,616
359,863

The allocation has been determined on the basis of time spent by staff.

27

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

18. Grants paid and future commitments

The following institutional grants, in respect of research projects in furtherance of the charitable activities, were treated as grants payable during the year:


Grant – The University of Newcastle
Grant – Queen Mary University London
Grant – World Duchenne Organisation
2022
£
21,426
25,320
-
46,746
2021
£
50,000
-
912
50,912

The following payments in respect of research projects have been committed to but not provided for in the accounts:

Grant to The Univerisity of Newcastle
Grant to Queen Mary University London

2022
£
-
-
-
2021
£
21,426
25,320
46,746

19. Reconciliation of net income / (expenditure) to net cashflow from operating activities



Net surplus/(deficit) for the reporting period
Adjustments for:
Depreciation charges
Loss on disposal of tangibles
Interest payable
Grant income related to bounce back loan
Dividends, interest and rents from investments
(Increase) / decrease in debtors
Increase / (decrease) in creditors
Net cash provided by (used in) operating activites
2022
Total
£

202,323
960
851
2,034
(1,250)
(19)
18,612
(135,057)
88,454

28

ACTION DUCHENNE LIMITED

NOTES TO THE FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2022

______________

20. Analysis of cash and cash equivalents




Cash in hand

2022
£
475,928

475,928
2021
£
396,747
396,747

21. Commitments under operating leases

The Charity had annual commitments under non-cancellable leases as set out below:




Operating leases which expire: within two to five years
Loans and overdrafts



Bank loans
Payable within one year

Payable after one year
2022
£
-
2022
£
44,264
10,022
34,242
2021
£
-
2021
£
50,000
5,833
44,167

22. Loans and overdrafts

The long-term bank loan is secured by fixed and negative charge over all the assets of the Charity.

23. Events after the reporting period

There are no events after the reporting date which require disclosure in the financial statements.

24. Restated comparative figures

In the prior year there was an over accrual of debtors. This resulted in assets and income being materially overstated. This came to light due to circumstances which occurred after the financial statements were signed and issued. The comparative figures have been restated.

29