**Registered charity number 1073581**
## **Manchester Neurological Research Trust Fund**
**Annual Report and Receipts And Payments Accounts**
**for the year ended 5 April 2023**
**Manchester Neurological Research Trust Fund Report of the Trustees for the year ended 5 April 2023**
The Trustees present their annual report and unaudited financial statements for the year ended 5 April 2023.
## **Reference and Administrative Information**
Charity name
Manchester Neurological Research Trust Fund
Charity Registration Number 1073581 Registered Office Cerebral Function Unit Manchester Neuroscience Centre Salford Royal NHS Foundation Trust Salford M6 8HD
## **Trustees**
Dr Anna Richardson Dr Matthew Jones Dr Christopher Kobylecki
## **Key management personnel**
The charity has no employees. Management is provided by the board of trustees
## **Independent Examiner**
Paul Cowham MA FCA DChA Withington Works Withington Baths 30 Burton Road Manchester, M20 3EB
## **Bankers**
Adam & Company 6 Adelaide Street London WC2N 4HZ
Coutts Bank 440 Strand London WC2
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## **Manchester Neurological Research Trust Fund Report of the Trustees for the year ended 5 April 2023**
## **Structure, governance and management**
## _**Company status**_
The charity is an unincorporated charity constituted under a trust deed dated 28 December 1953.
## _**Governing document**_
The charity's governing document is a trust deed dated 28 December 1953.
## _**Recruitment and appointment of Trustees**_
Appointment of other trustees is at the discretion of the serving trustees. Training would be offered to new trustees by the existing trustees.
All decisions made on behalf of the charity are made by the trustees.
## _**Risk Management**_
The trustees have conducted their own review of the major risks to which the charity is exposed and systems have been established to mitigate these risks. These procedures are periodically reviewed to ensure that they still meet the needs of the charity.
## **Objectives and activities**
## _**Objects and aims**_
The objectives and activities of the charity are the research and scientific investigation into the causation, prevention, diagnosis and treatment of illness resulting from disease of the nervous system. The focus of the Trust’s activities is on dementia research. The Charity supports clinically based research as well as collaborative research with basic scientists from national and international academic research centres.
The trustees confirm that they have referred to guidance contained in the Commission's General Guidance on public benefit when reviewing the Trust's aims and objectives and in planning future activities and setting the grant making policy for the year.
## **Achievements and performance**
The clinical research group has continued to collaborate with basic scientists in the University of Manchester, with a research focus on Alzheimer’s disease, the frontotemporal dementias and Motor Neurone disease.
Clinicopathological correlation remains a research focus, integrated within the Manchester Brain Bank.
Other work, in collaboration, is aiming to identify biomarkers in serum, in advance of what are hoped to be promising monoclonal antibody treatments becoming available to treat Alzheimer’s disease in its early stages.
We continue to sponsor a junior neurologist in his MD, the research performed in collaboration with the Cerebral Function Unit (CFU), Salford Royal Hospital and the University of Manchester. This two-year project focuses upon dementia that begins with pure language problems, known as Primary Progressive Aphasia. These are less common than other forms of dementia and currently have no medical management to halt or improve disease course. This research has developed a novel approach for targeting tDCS which has never before been used for PPA and the work has been presented at a regional neuroscience meeting (MAHSC Neuroscience Showcase 2023). They are currently writing a thesis titled 'Optimising diagnosis, prognosis, and treatment for Primary Progressive Aphasia using neuropsychology, neuroimaging, and neurostimulation' with the overall objective of developing a safe and practical therapy for patients who battle their illness without an effective form of medical treatment.
The charity has employed a psychology assistant to help maintain a clinical research register & screen clinics for patients who may wish to participate in current research studies. They assist with current research projects in the department such as data collection/preparation & neuroimaging data analysis.
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## **Manchester Neurological Research Trust Fund**
## **Report of the Trustees for the year ended 5 April 2023**
## **Financial review and reserves policy**
During the year the charity received donation income of £500 (2022: £4,169), investment income of £28,931 (2022: £26,411). £11,855 (2022: £2,860) was used in furtherance of the charity's objectives.
The charity had cash reserves of £176,011 as at 5 April 2023 (2022: 158,735). The trustees recognise that this is in excess over what it needs and are planning on ways to spend this in advance of the charity’s objects. This should help bring reserves down to a more realistic level and is in line with the charity’s objects.
## **S tatement of Trustees’ responsibilities**
Law applicable to charities in England and Wales requires the trustees to prepare financial statements for each financial year which give a true and fair view of the charity's financial activities during the period and of its financial position at the end of the period. In preparing financial statements giving a true and fair view, the trustees should follow best practice and:
- Select suitable accounting policies and then apply them consistently;
- Observe the methods and principles in the Charities SORP;
- Make judgements and estimates that are reasonable and prudent;
- State whether applicable UK Accounting Standards and statements of recommended practice have been followed, subject to any material departures disclosed and explained in the financial statements[
- Prepare the financial statements on the going concern basis unless it is inappropriate to presume that the charity will continue in operation.
The trustees are responsible for keeping proper accounting records that disclose with reasonable accuracy at any time the financial position of the charity and enable them to ensure that the financial statements comply with the Charities Act 2011. They are also responsible for safeguarding the assets of the charity and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.
The trustees are responsible for the maintenance and integrity of the charity and financial information included on the charity’s website in accordance with legislation in the United Kingdom governing the preparation and dissemination of financial statements.
Approved by the Trustees and signed on their behalf by:
…………………………… Dr Anna Richardson
30/06/2024 …………………………… Date
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## **Independent Examiner’s Report to the Trustees of**
## **Manchester Neurological Research Trust Fund**
I report on the accounts of the charity for the year ended 5th April 2023 which are set out on pages 5 to 7.
## **Respective responsibilities of trustees and examiner**
The trustees are responsible for the preparation of the accounts. The trustees consider that an audit is not required for this year under section 43(2) of the Charities Act 2011 (the 2011 Act) and that an independent examination is needed.
Having satisfied myself that the charity is not subject to audit under charity law and is eligible for independent examination, it is my responsibility to:
- examine the accounts under section 145 of the 2011 Act;
- to follow the procedure laid down in the general Directions given by the Charity Commission under section 145 (5)(b) of the 2011 Act; and
- to state whether particular matters have come to my attention.
## **Basis of independent examiner’s report**
My examination was carried out in accordance with general Directions given by the Charity Commission. An examination includes a review of the accounting records kept by the charity and a comparison of the accounts presented with those records. It also includes consideration of any unusual items or disclosures in the accounts, and seeking explanations from you as trustees concerning any such matters. The procedures undertaken do not provide all the evidence that would be required in an audit, and consequently no opinion is given as to whether the accounts present a ‘true and fair view’ and the report is limited to those matters set out in the statement below.
## **Independent examiner’s statement**
In the course of my examination, no matter has come to my attention:
(1) which gives me reasonable cause to believe that in any material respect the requirements:
- to keep accounting records in accordance with section 130 of the 2011 Act; and
- to prepare accounts which accord with the accounting records and comply with the accounting requirements of the 2011 Act
have not been met; or
(2) to which, in my opinion, attention should be drawn in order to enable a proper understanding of the accounts to be reached.
Paul Cowham FCA DChA Green Fish Resource Centre 46 – 50 Oldham Street Manchester M4 1LE
2 July 2024 _Date ………………………_
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## **Manchester Neurological Research Trust Fund**
Year ending 5 April 2023
|**Receipts and Payments Accounts**
**_2023_**
Unrestricted
funds
**Receipts**
£
Bank interest
671
Investment income
28,931
Donations
500
Sale of investments
-
Total receipts
**Payments**
**Research activities**
Research laptop
774
Conference expenses
580
CFU website
571
Pathological processing
680
PHD study
9,250
**Administrative costs**
Portfolio management fees
-
Independent examiner's fees
750
Legal and professional fees
-
Bank charges
5
Just giving charges
216
Total payments
Net of receipts/(payments)
Cash funds last year end
Cash funds this year end|**_2022_**
_Unrestricted_
_funds as_
_restated_
_£_
_13_
_26,411_
_4,169_
_-_
30,102
_-_
_-_
_-_
_2,760_
_100_
11,855
_-_
_840_
_-_
_38_
_216_
971
12,826
17,276
158,735
176,011||
|---|---|---|
|||_30,593_|
|||_2,860_|
|||_1,094_
_3,954_|
|||_26,639_
_132,096_|
|||_158,735_|
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## **Manchester Neurological Research Trust Fund**
Year ending 5 April 2023
## **Statement of assets and liabilities at the end of the year**
|Notes
**Cash funds**
Bank balances
1
Cash held by investment managers
**Investment assets**
**Assets retained for the charity's own use**
Research laptop
Microscopy equipment
**Liabilities**
Professional fees
32512.298 M&G Charifund Units, market
value at 31 March 2023 £482,213
115423.7 Brown and Shipley Growth 1
Fund Units, market value at 31 March
2022: £244,443
14 Smith and Nephew US$20 shares|**_2023_**
Unrestricted
funds
£
175,996
15
176,011
**Cost**
172,909
140,484
12
313,405
**Cost**
774
4,000
4,774
1,500|**_2022_**
_Unrestricted_
_funds as_
_restated_
_£_
_158,720_
_15_|
|---|---|---|
|||_158,735_|
|||**_Cost_**
_172,909_
_140,484_
_13_|
|||_313,406_|
|||**_Cost_**
**_-_**
_4,000_|
|||_4,000_|
|||_1,500_|
Signed on behalf of the trustees:
Dr Anna Richardson
_Name Signed_
30/06/2024
_Date_
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