Diabetes Research and Wellness Foundation (A Company Limited by Guarantee) Charity Number: 1070607 Company Number: 03496304 Flnanclal Ststements For the year ended 31-Dac-23 Diabetes Research and Wellness Foundation INDEX Page Report of the Trustees 1to33 Independent Auditors, Report 34to37 Statement of Financial Activities 38 Balance Sheet 39 Statement of Cash Flows 40 Notes to the Financial Statements 41to49 iabetes Research Wellness Foundation Diabetes Research and Wellness Foundation (DRWF) (A Company Limited by Guarantee) REPORT & FINANCIAL STATEMENTS For the year ended 31 December 2023 Re8lstered Charlty Number.. 1070607 Company Number: 03496304 THANK YOUI To everyone who has donated, volunteered their time, or undertaken an activity to support Us. Your contribution makes all the difference, meaning that we can carry out awareness, educational programmes and research funding activities to ensure that people with diabetes are 'Staying well untll a cure isfound... THANK YOU! for being part of a powerful community who are intent on investing in a brighter future for all people with diabetes #StrongerTogether #UnitedThroughDiubetes Tru$t Informatton Creator FR Oiabere5 Research Wellnpss F4hJrthtlon Message from Co-Founder & Chairman Mike Gretschel l am Mike Gretschel a co-founder and Chairman of DRWF. It has been overfifty years since my dear wlfr called me at the office crylng that "our son has type I diabetes and there is no cure". I trled to calm her, but my words were not enough. Thut was just the beglnning. Ten years later our eldest daughter was also dlagnosed with type l. And now my son's son has type I too. My wife and I have devoted much OA ourfree tlme, with fvmlly andAriends ralslng awareness and the monles necessary to support vltal research. We have been flghtlng the dlabetes battle In the hope of a curefor all these years. We live In hopel As DRWF turned 25 years old in 2023, we paused to reflect on the diabetes landscape. Twenty-five years doesn't seem so very long, but the number of people living with diabetes in the UK has more than doubled in that time. We have worked tirelessly in that time to raise awareness of the different types of diabetes and provide people with the practical Information and tools to support their self-management. As a small team of just 14, we are supported by editorial and research advisory boards, as well as other experts in the field of diabetes and related health, who help us to deliver activities that demonstrate value for money, and most importantly benefit for the dlabetes community. The one thing that binds us all together, is the fact that we are all striving for the same thing. Together, we are Unlted through Dlabetes. Over 25 years, we have supported some of the most innovative research in the UK and around the world. The DRWF Islet Isolation Facilty at the Churchill Hospital, Oxford is pivotal to the UK Islet Transplant Programme, a clinical treatment that support5 a small number of people with type I diabetes through transplant of insulin-producing islet cells. Whilst the clinical element of this treatment is funded by the NHS, and the results for many are impressive, there are limitations that hamper long-term results and prevent more people from benefiting. To address some of these Issues, we funded a xenotransplant programme in the US called the Spring Point Project, which was focused on providing an alternative, sustainable supply of islets for human transplant using pigs. Additionallyi we have supported a plethora of stem cell-based research projects In the hope of finding ways to develop and sustain the islet transplant programme. All the while, providing funds for early career researchers and proof of concept awards which are demonstrating impact for the diabetes community. Some of these examples you can read about in our report or on our webslte. Whilst we have achieved a lot in our 25 years, there is still so much more to do, and we could not do it WSthout YOU I We are so grateful for the longstanding support that we get from donors, sponsors, and partners and are rightly proud of what we have brought to the table, together, for people with diabetes. From the bottom of my heart... Thankyou! Mike Gretschel March 2024 TRUSTEES ANNUAL REPORT FYE2023 OiabÈt¢s RèsÈarch Welifftess Foundadon st Report of the trustees for the year ended 31 December 2023 The trustees are pleased to present their report and message from the Chalrman together with audited financial statements for the year ended 31" December 2023. The financial statements comply wlth the Charities Act 2011; the Companles Act 2006; the Memorandum and Articles of Association and are prepared in accordance with the Flnancial Reporting Standard applicable In the UK and Republic of Ireland IFRS 102 Charities SORPI {effective from 1st January 2015). Our purpose, aims and activities The objects of the charity are,, To assist In the rellef of persons wlth diabetes and any simllar or related dlseases or conditions To ralse public awareness about dlabetes and any simllar or related dlseases or condltlons, thelr Incldence, causes, treatment, avoidance, and relief The focus of our work th As we entered the charity's 25 anniversary year, we took time to reflect on the dlabetes landscape and the charlty's impact over that time. Since inception in 1998, the number of people dlagnosed with dlabetes has more than doubled. Whllst there have been some Incredible advances In treatment and technology in more recent tlmes, whlch improve quality of life and reduce the risk of complicatlons, the number of people Ilvlng with dlabetes continues to rlse at an alarming rate. With more than 5 million people now living with dlabetes In the UK, our work to provide self-management support, 15 more Important than ever. Whilst recognlsSn8 25 years of raising awareness, provlding award-winnlng Diabetes Wellness support pro8rammes, and funding the research that we hope wlll one day flnd a cure, we used thls mllestone anniversary to reflect, rethink and redouble our efforts to ensure that people with diabetes are 'staylng well untila curelsfvund... Our focus In 2023 was to ensure that we offered Wellness programme actlvltles that met need and delivered Impactful outcomes whilst maxlmisln8 opportunity for DRWF to enga8e in partnerships that delivered revenue and benefit for all parties. To thls end, we- Revlewed our Research Strategy to ensure that the awards we offer remain attractive, financially sound, flt for purpose and demonstrate impact for the researcher and the diabetes community. Re-organised our Diabetes Wellness event programme to deliver United Through Dlabetes, a wonderful concept that brings the diabete5 community together with healthcare professionals, public health officials, third sector organlsations and industry partners. All of whom are invested and intent on creating a brighter future for people with diabetes. Restructured our supporter database to ensure that we are taking a personalised approach to stewardship of beneficiaries and donors to improve recruitment and retention rates. Re-organised internally to form a Supporter Services Team which helped to create cost efficiencie5 by enabling us to bring a costly outsourced service In-house. Worked hard to diverslfy fundraising activities to reduce reliance on single income streams- an ongoing process but one which helps to ensure thatthe charity has sustainable income sources and fitforthe ￿ture. TRUSTEES ANNUAL REPORT FYE2023 Diabete5 Research Et Wellne55 Fovnd•Jon Demonstrating public benefit The trustees confirm that they have referred to the general guidance set out by Charity Commission on public benefit. The trustees are satisfied that the Charitws activities meet the principles of public benefit, defined as providlng an identlfiable benefit/s to the publlc, or sectlon of the public, and know of no detriment or harm that may be caused as a result of these activities, which are clearly set out throughout thls report. Volunteers As a small team delivering numerou5 actlvities, we rely on the support of volunteers who partlcipate by helping with administrative tasks in our office; delivering diabetes awareness and information materials; undertake user involvement exercises to help steer and develop our programme activitles; support our educatlonal events and community fundraislng programme or slt on one of our expert panels for research or Information review. The number of volunteers fluttuates each year but Is crucial to helplng us spread the word about the work we do and to support local and national community initlatlves. In addition to ourTrustees, we have an Editorial Advisory Board and a Research Advlsory Board. These are panels of diabetes clinlcians and scientlsts, and other relevant professionals and lay people, all of whom offer their time and expertise voluntarily to ensure that we meet the high standards required of us through our Associatlon of Medical Research Charities IAMRC} accreditation and our commltment to producing clinlcally evidenced health and soclal care information. We wholeheartedly thank all of our volunteers for thelr tlme, expertise and commitment which helps us raise awareness to the charltyi maxlmlse income and malntaln hlgh standards of work. Measuring Impact We use a mixed methods approach to monitor and evaluate our actlvitles In order to ensure that they remain true to purpose and achleve deslred outcomes. Stakeholders and beneflclaries are involved in these evaluatlon processes to ensure the continued relevance, quality, accessiblllty, and effectiveness of activlties. We also undertake Independent evaluatlon with specialist partners for speciflc projetts where impartlal oplnlon and/or additlonal expertise Is required. We keep people with dlabetes at the heart of what we do. Beneficiaries and supporters are Involved In numerous ways to ensure that our support and resources are relevant, accessible and meet need5, helplng to Steer our research prlorities and pro8ramme actlvlties. th Activities & Achievements in 2023- 25 Anniversary Year Awareness, information & support INFORMATION REACH: Whllst recognlsing that a large percentage of exlsting supporters and beneficiaries engagethrough offllne channels, it was important thatwe diverslfy our reach of a wider demographic of the dlabetes community in 2023. We distributed 192,181 campalgn appeals In 2023 to existlng supporters through dlrect mail and reached 29,762 prospectlve beneficiaries and supporters with new awareness campaigns. These appeals are dual purpose raising awareness and providing information about the charity's activities and funding, whilst seeking financial support. They also act as a stewardship tool, helping us to stay connected with long-standin8 supporters of the charlty. Each campalgn provlde5 health information targeted at beneficiarles who could act on the information, either in a preventative way (type 2 diabetes), or to inform and support those Ilvlng with diabetes lall types), in their self-management of the condition. We had an average campaign response rate of Il% acros5 3 streams resulting in over 24,818 responses from across the country. We know from experience that it is likely that many more opened and read the appeal but chose not to make direct contact with us at that time. Historically, we TRUSTEES ANNUAL REPORT FYE2023 Di6bÈtES RÉsÈarth Et Wellness Foundation have seen numbers of people respond to communications that have been distributed many months, or even years, before as they have held onto the information provided for future reference. WEBSITE: Our onllne reach was significantly reduced In 2022 followlng a splke of engagement with our content in 2020/21 due to the pandemlc, There were numerous reasons for this, and our goal was to remedy this situation in 2023, which we did most successfully. Visits to our website increased by 58% from 173,992 to 275,000 visits in the year. Traffic was consistently higher throughout the year instigated by news content and social media campaigns in support of our activities. Updates to our patient information resources started In 2023 with rebranding of our leaflets. These resources are available from our website in pdf and audio format, provlding choice of accessibility. We also offer to provide enlarged print versions of all health and social care resources. There were 8671 downloads of patient informatlon leaflets in the year, with hat Is DlabetesP', 'A healthy Diet and Dlabetes,, and 'Exerclse and Diabetes,, being the most popular. Additionally, 6905 leaflets were dlstrSbuted in hard copy during the year to dlabetes and related healthcare professlonals who order the resources In bulk for dissemination via their cllnics. ¢..) DiabÈies Reseaich & Wellness FoDnd4ilor* .'1 Dlabeios et w￿1￿•$$ Foundaiio A healrl)y DIET and DIABETES Imp￿￿Tht tw p•Op￿4￿•1n¢W1th i por i PLIF The news section of our website is at the top of the Ilst in generatlng trafflc, followed closely by the 'Llvlng wlth Dlabetes, sectlon whlch hosts our Information resources. There was also a significant Interest In our Wellness Programme and th specifically our 25 Annlversary event 'United Through Diabeteg. These three sections alone, accounted for almost 68,000 unlque visits in the year. 1B N¢v1025 The post-event 'Unlted Through Dlobetes, Dlgital Hub and subpa8es, received 2,499 views from 1,550 individual users, who visited more than once. This content was designed to disseminate the workshops and sessions delivered through our Wellness event to a wider audlence who access information online. LIVING WITH DIABETES PODCASTS & VIDEOS: We continued to produce our Living with Diabetes podcasts in 2023 which provide5 another channel through which to access interesting and i educational diabetes content. Whilst these channels are still very much a work in progress, we have had reasonably good engagement during the year with 3,800 visits an increase of 30% on 2022. We alm to develop these channels during 2024, TRUSTEES ANNUAL REPORT FYE2023 Diabetes Resear(h WdlTress foundatlon SOCIAL MEDIA CHANNELS: Social media channels are a great wayto reach a wideraudlencei quicklyi with messages about our actlvities. Whilst we use multiple social media channels, we get greatest engagement in posts about our community activities via Facebook. Combined Facebook and Instagram reach was up around 15Yo in 2023 over 2022 with an equivalent increase in spend in the vear. These channels also drive traffic to our webslte which was almost 60% up on 2022. DIABETES WELLNESS NETWORK: We made changes to the way In which we produce and distribute our Diabetes Wellness Newsletter in the year. This is a subscriber activity which has historically been sent out monthly but due to rislng productlon and postage costs, we Increased pagination and changed distribution to quarterly. We have had good feedback on the addStlonal content contained within the publication and we have not seen a downward trend in volume of renewals, otherthan those anticlpated each year. Importantly, without decreasing value to our supporters and beneficlaries, we were able to reduce the volume of hard copy new51etters clrculated In the year to 52,600 which helped to reduce our costs by around 41%. The intention is to make this newsletter avallable electronically going forward, but through survey of existing subscribers, this audience wish to continue receiving their printed magazine. This is somewhat due to the demographlc proflle of subscriberwlthin this programme, and we expect thls to change as we reach a wider section of the dlabetes communlty who are famlliar and at ease wlth dlgital channels. PATIENT INFORMATION FORUM (PIF) TICK: As members of the Patlent Informatlon Forum, we applied for PIF Tick accreditatlon on our adult health and social care resources. Followlng the robust revlew process operated by PIF we gained the PIF Tick kite mark which Is displayed on our Information resources. This demonstrates that we are a 'trusted information creator, whlch Is an Important way In whlch people seeking our help can recognise that our information 15 relevant, up-to-date, clinically referenced and peer revlewed. Quality In Care Diabetes- award winning Diabetes Wellness events: Self-management Is the cornerstone of dlabetes care, wlth good self- management skllls e55ential to achleve posltlve health outcomes and reduce the risk of associated health compllcations. For the past 23 years, DRWF has been provldlng an annual programme of Diabetes Wellness events that are focused on enabling people to access relevant, evidence-based health informatlon throughout the lifetlme of their lon8-term condition. Whllst provldlng a wide range of diabetes and related-health workshops, interartive sessions and talks, the core prlnclple on whlch this programme Is bullt Is 'peer support., Peer support 15 a valuable resource for people living with diabetes, thelr famlly, frlends and carers and ou r Wellness events provide an opportunity to make new contacts and build new relatlonshlps through mutual acceptance and understandlng, in a safe and inclusive envlronment. Our events inform, inspire and empower people to take ownership of and have more control over theSr health and wellbeing. The diverse learnlng programme on offer helps people to develop knowledge, skills and confidence to address issues that are affecting their health and diabetes self-management. This is especially beneficlal to people who are lonely or isolated and don't have an immediate support network around them. We belleve that this holistic approach supports all round wellbeing and increases learning capacity and resilience, and it is wonderful to see people return to our events year-on-year. th In our 25 anniversary year, our focus was on scaling our award-winning Wellne55 Day to reach a wider and more diverse diabetes audience, increasing footfall and incorporating 'research' into the programme. This gave us the TRUSTEES ANNUAL REPORT FYE2023 Diabetes Researth Es Weiines5 Foundation opportunity to showcase the research that the charity has funded over the last 25 years and demonstrate the impact that this work has had for the diabetes community. This new event was an opportunity to demonstrate that together, we are 'Unlted Through Diabetes.. United Through Dlabetes- the BIG Diabetes Wellness Day 443 On Saturday 16 September, we hosted the inaugural Unlted Through Dlabetes event which saw 443 delegates in attendance. This event was launched to mark the charity's 25 annlversary year to provide a one-stop shop of 'everything diabetes,. The event was supported by Industry partners, and prominent speakers, such as the deputy clinical diabetes lead for England, Professor Partha Kar. The event reached a wide and diverse segment of the diabetes communlty, including families of chlldren wlth type I dlabetes, people with type I, type 2 and other types of diabetes, as well as people working in diabetes and related healthcare. Just one of the highlights of the event was the opportunlty for people to engage wlth DRWF funded researchers, past and present, to understand how the work we have invested in over the i.. past 25 years has delivered Impact/beneflt for people with diabetes. Feedback on the quality and variety of l., workshops and talks on offer was extremely positive and the UTD Dlgltal Hub extended our reach post-event to enable people who couldn't attend to benefit from *. the programme content. 86 Dlabetes Wellness Family Camp th Family Camp took place on 18 August at Whitemoor Lakes In Staffordshlre. We received 34 famlly applicatlons1117 individuals). Whllst our target was to accommodate 60 individuals, we were able to offer places to 86 people from 24 families. There Is a robust trlage process in place for Family Camp 8iven that many children are livlng wlth complex health needs beyond type I diabetes. All those that dld not meet the crlteria for ' We stepped out of our comfort zone, and it brought us together., Opportunity to talk to other children/parents who have type I diabetes, time as (7 family. Famlly Camp were offered places at our Autumn vlrtual Camp in the Cloud. The alm of Camp is to bring families of children with Type I diabetes together in a fun, safe and welcoming environment. The emphasis is on providing fun for the child ren and a little respite for the parents/guardians and perhaps most importantly, providlng a platform for meeting families to share similar experiences of life wlth dlabetes so as to build relationships based on mutual understanding and acceptance. 'Meeting new people. Shar'ing ex eriences. TRUSTEES ANNUAL REPORT FYE2023 Dlabotes Research £* Wellne55 Fosjndation Feellngs before attendlng Camp... HopofiiL Ai)pi eliiTrii¥ivo E.undatlon percentage to previous years. Non-attendance can happen for several reasonsi poor health, unable to travel etc., and so families who can't attend for clear reasons are offered places at the next CITC. A full programme of onllne activities was offered, with a box of arts and crafts, and other materials, supplied beforehand to make the day as interactive and fun as possible. DRWF hosted a Yalking Typel, session for the families where they could raise important questions with our guest speaker, Heather Holland, DSN. Fun was had during the day with the DRWF Dance for Diabetes session which all attendees participated in, led by dance teacher Megan. The day concluded with a closing ceremony and games, 30 Diabetes Wellness Morning- Hartlepool The Diabetes Wellness Morning held In Hartlepool was a new take on the event that the charity has been providing for the last 11 years in the Northeast, Hosted on behalf of DRWF by longtime volunteer, Hayley Hakansson, the event was held to reco8nlse World Diabetes Day and mark the 25th anniversary of the charity. The Wellness Mornin8 was held at the National Museum of the Royal Navy and was attended by 30 people. The alm of the morning was to support people15vlng with diabete5, their famlly, and carers, to provlde practical Information, tools and tips to improve self-management and understanding of the condition whilst providlng an opportunity to spend tlme with diabetes healthcare professionals. The event was organised with the support of the Hartlepool Diabetes Support Group and colleague5 at the North Tees and Hartlepool NHS Foundation Trust. Attendees enjoyed a busy mornlng featuring presentations on diabetes and a question-and-answer 5es5ion from guest D13betes Specialist Nurses Julle Sinclair and Patricia Lowther. Hayley said: Everyone attending the event said how warm and welcoming the Wellness Morning was and they felt they had learned something new, In addition to refreshing thelr knowledge of helpful tlps for living with diabetes." In the build-up to the event Hayley promoted the Wellness Morning with an appearance on the Radio Hartlepool breakfast show, talking to presenter Jason Anderson about her voluntary roles In her local community and encouraging people with diabetes to attend the Diabetes Wellness Morning. Research Funding Programme Each year, we issue Calls for Applications In respect of our 3-year Clinical, Non-clinical and Pump Priming award5. DRWF Fellowships provide the necessary funding to support Early Career Researchers IECR) whlch is vita Ily Important to ensure that clinical and scientif ic talent stays a nd develops within the diabetes medical research community. ECR'5 represent a young and diverse research population, and provide a constant flow of talent, new ideas and new skills. Some of them will 80 on to be the senlor diabetes researchers of the future, so with very few funding awards available to this vital community, the DRWF awards are lucrative and well positioned to attract the best and brightest young researchers. TRUSTEES ANNUAL REPORT FYE2023 Di•betes RèsÈaich Ep Wollness Foundation Our Pump Prlming stream is a proof-of concept funding channel, which aims to produce translational pilot study data that goes on to leverage higher value, longer term funding from other organlsations to take the research conducted to the next level. The DRWF annual funding round is offered through open competition, and as such, enables funded researchers to access support for both indirect and direct costs of research via the Charity Research Support Fund ICRSF) and NIHR Cllnical Research Networks ACORD agreement. Instttutional and discretionary awards are available when funds allow. Contract funding of key personnel within the DRWF Human Islet Isolatlon Facility at the Churchill Hospital, Oxford is subjectto proposal and revlewed on a multi- year rolling contract basis. DRWF Is a member of the Assoclation of Medical Research Charlties (AMRCI, a membership body representing the leadlng medical and health research charlties who deliver high-quality research that saves and improves Ilves. Working wlth member charities and partners, AMRC aims to support voluntary sector effectiveness and advance medical research by developlng best practice, provldlng informatlon and guidance, Improvlng publlc dlalogue about research and science, and Influencln8 government. As a member, we subscrlbe to AMRC'S crlterla forthe use of peer revlew for allocatlng fundin8 and support AMRC position statements on the payment of indlrect costsln unlversltles and the use of animals In medlcal research which seeks to replace, reflne and reduce the use of anlmals13Rsl In research. We operate a rlgorous peer revSew process by whlch our Research Advlsory Board (RAB), clinlcal and sclentiflc experts in the fleld of diabetes and related health, asse55 appllcatlons and reports to ensure that only the hlghest quallty and most effectlve research, carrled out using good or best practlce methodologles, receives DRWF fundlng. Clalre Levy - Ilvlng wlth T2 Dlabetes Funding research into new treatments and new technologies has transformed the lives of people living with allforms of diabetes Includlng myself as someone with Type 2 Diabetes. DR WF has funded some amazing research over the last 24 years, made posslble by the very generous donations of our supporters, which has really advanced our knowledge of the different types of diabetes and how to manage and treat it. We will onlyfind a cure through research and your gift could moke all the dlfference." 4ESEARCH Research Advlsory Board Strategy Day The charlty's Research Advisory Board (RAB) met in March to review current fundin8 Streams and conslder whether awards are delivering value for money, for DRWF, the researcher/institution, and perhaps most Importantlyforthe diabetes ¢ommunlty. Past and currently funded researchers were Invited to present to the RAB from across Fellowship, Pump Priming and Contract Funding streams. The RAB were Impressed by the results that have been seen in all strand5 of fundin8 whetherthat be Pump Priming funding collecting translational pilot study data which has gone on to prove a new concept and leveraged additional funding for a wider body of work to be undertaken, or career progression which has helped develop and retaln expertise in the dlabetes research arena, whilst leveraging higher value multl-year funding for further work. The Strategy Day resulted In a recommendation to the harity's Board of Trustees to uplift Fellowship awards to ensure that they remain attractive and competitive with increasing salarles and consumable costs. This was approved by the Board and will be offered with the next call for applicatlons for Fellowshlp grants. The discussions and information collected at the Strategy Day enabled the update and publication of the charity's Research Strategy for 2024-26. 10 TRUSTEES ANNUAL REPORT FYE2023 Diabete5 Researth ty Wellness FOUnd￿On Diabetes Research Wellness Foundation searc Strategy 2 24-26 P2 JSJ RESEARCH Diabetes Research & Wellness Foundation TRUSTEES ANNUAL REPORT FYE2023 OiabetÈs Research I￿URe$s Foundatio Pump Priming Awards Calls for applications were Issued In September 2023 for Pump Prlmlng Awards to be taken up In 2024. A total of 20 applicatlons were received from which six research awards were made with a total value of £119,982. The DRWF research programme is designed to support bright young researchers, as well as established Institutions, as they strive to makethe klnd of Ilfe-changing breakthrough our diabetes community Is hoping for. Pump Priming awards considered 'proof of concept, and are either Cllnical or Non-clinical in nature. Successful projects are funded for up to two year's duration, to the value of £20,CQO. No-cost extensions to the term may be considered. Nottingham Trent Dr Adalkala Antonysunll University Nottingham Trent Universltv £20,000 Tltle: Integrated omlc5 to Identlfy the epltranscrlptomlc Interartlons between methyl modlflcatlons of mature mlRNAs and tmnscrlptome in placenta due to mlcronutrlent IB12J defl¢lency promotlng dlabete5 In pregnancy ' I Lay Summary: Obesity in pregnancy has adverse effects on both mother and baby and predlsposes them to heart diseases later In life. Women of chlld- bearlng age, pregnant, lactating and women adherlng to vegan diet are at much hlgher rlsk of B12 deficiency, and thelr offsprlng are at elevated rlsk of low blrth weight and preterm blrth. This led to significant Interest in understandin8 the maternal dlet durin8 pre8nancy. My research showed that pregnant women with low B12 have higher sugar and fat levels in the blood and develop more body fat, whSch are slgns of hlgher risk for heart diseases in later life. However, the causal reason is unknown. B12 Is one of the key mlcronutrlents turning the blological swltch on/off for the methylation process, which is responsible for efficient funrtioning of small RNA molecules called microRNA that control genes and cellular process. Here I propose that when B12 levels are deficient, the methyl groups normally added to the microRNA are reduced. This results In dysfunctlonal microRNAs which could profoundly change gene/proteln products and contribute to disease development. The aim is to characterise the methylation sites and Identify the gene targets of microRNAs at the tissue level caused by low B12 using advanced technologies, This approach will identify new pathways affected and detect new targets that could enable tailored therapies in specific patient subgroups to treat diabetes. Benefits are anticipated to enhance the potential for the individualized health care and management of patients with diabetes durlng pregnancy. 12 TRUSTEES ANNUAL REPORT FYE2023 Oioberes Research Et WellnÈ55 Foundation Dr Steven Millership Imperial College London £20,000 rial Co lege Tltle: Repurposing epldrugsfor Aunrtionul enhancement oAhuman puncreatic beta cells Lay Summary: Insulin-secreting beta cells of the pancreas are what are I,: destroyed or become dysfunctional In dlabetes. To restore this functionality, methods have previously Included to transplant isolated islets from donor patients, however thls ha5 been met with problems of survival of lifelong immune suppresslon for the patient, and the survival of the implanted islets themselves. Several research groups have made pioneerin8 progress over the last decade by uslng stem cells originally from the patient, that have a capaclty to become any cell in the body and generatin8 beta cell "like" cells uslng a cocktail of various compounds over multiple stages of beta cell development in the laboratory, Wh3t these cells lack however is their'incomplete" levels of maturity to become a fully functional beta cell, as measured by the amount of insulin produced and their capacity to secrete it into the bloodstream. We hypothesise that the m15slng element are pathways that regulates the expression of key beta cell genes land therefore beta cell maturation) in the body, known as epigenetic pathways. We will screen a large number of commercially available compounds that target these epigenetic pathways known as "epidrugs" and assess their ability to enhance human beta cell maturation In a cellular model system. Our goal Is to Interrogate the role that these novel epigenetic pathways have on beta cell functlonal maturation and ultimately to assess thelr abillty to enhance the functionality of stem cell-derived beta cells prior to transplantation into patlents with diabetes. Dr Ellzabeth Haythorne Edlnburgh Universlty £20,000 114. III-L.L)INIIUII(yl I Tltle: Does portlal Inhibitlon of glucokinase protert human pancreatlc beto. 2023 2022 No. No. The number of higher paid employees w8s in the band: £60,000- £70,000 Pension contributions payable for the above individual was £2,776 {2022: £2.776). The number of employees at the end of the year was 13 (2022: 15). Diabetes Research and Wellness Foundation Notes to the Financial Statsments {Continued) For the year ended 31 December 2023 12 Paymont8 tts Trusteè8 No trustee or person with a f¥mity or business connection with a trii8lee, recefved remuneration In th8 yeaf, directsy or indirectly. from the charity. Reimbursement to Trustee8 for Travel and mee￿n9 C0818 were £nil12022.. £nill. 13 Surplus of Income ov•r Exp•ndltur• 2023 2022 The surplus of income over exFenditure Is slated after charging.. Audilor8' Remunerali¢)n'. Audil Fee relatlng lo the FlnancSal Year In respect ol non aL￿trt 88NIc88 Oper8lino Lease rental8 Plant & Machlnery Other Assets Forelgn Exchange Lo88 Depreciallon 22,900 1,250 21,0 1,140 3.066 16,719 5,853 1,824 24,090 5,265 14 Tuatlon The cornpany, being a regi81ored charlty, Is not Ilable lor corporallon tsx in re8pecl of il¥ eharilable operations for the year. 16 Tanglbl• Flx•d A#*•ts for Ch•rlty U•• •qulpmont, IlxtUrn8 and flttlngB ¢08t At 1 January 2023 Additlon8 In Year Dispo8al$ In Year At 31 December 2023 37,027 11,203 29,274 D•pr•¢latlon Al 1 January 2023 Provided in the year Elimlnaled on Dis￿&￿1 At 31 December 2023 31,186 3,516 6,781 Net 8ook Value At 31 December 2023 At 31 December 2022 16 Debtors 2023 2022 Trade Debtors Other Debtors P￿paYmentS and Accrued Income 68.777 27,424 712,178 808 379 1,920 19,144 1,184,535 1205 599 All Debtors ex￿pt prepayments are financial instruments and are measured at settlement value 47 Dlabetes Rèsoarch and Wellness Foundation Notes to the Financial Statements Icontinued) For the year ended 31 December 2023 17 Credltorn '. Amounts falllng due wlthln one year 2023 2022 Trade Credllor8 Gfanls PayaNe (Bee bal￿ Accru* and Deferred Income T8￿￿ Soc[81 Security Olh8r Croditorn 44.805 248.706 82.274 17,932 124,587 210,Y55 54,652 14.260 AJI Cr8dllOTS except dof8rr8d h¢ome 8r8 fhanoal k7strum￿tt afftl aro meaw[￿l al 59tilem8nl v*ue Rgconelliatlon ofGr4nt• P4y•bl•.' Com￿1￿¥￿11 at 1 Jonu8ry 2023 Gran18 Paygt48 for tho Y88r 1888 Noto 81 GranL% P*d dulng Year 210,￿5 336.rJ8 311.343 273.$92 275.867 401 t38 248 706 In addl￿0Th tQ Ih•8mounts ¢ommttl•(I icer￿d n¢iod above, InJ81866 h8¥8 8180 aulh￿se0 Ihe ￿n11n￿81￿)n oi ¢8rt4ln oronl8 whl¢h ar• 8tA)i•th10 Ihe 4nt rulmung e•rtaln condNlon8. Tho dotolk8 of th880 further commllm•nlo e4n bo found In Note 22. 18 D•f•rr•d Incomo 2023 2022 Dèfèrre(S Incorne BIFWD 181 J•nu•ry 2023 R&￿sSed to In¢ome In Year Income Def6rred In Ytrar Deferred CIFWD 31NI Dg¢¢mtyer2023 3,360 13.3801 54.287 5,972 15,9721 Oafarrld Inceme ty)mprlso8'. . N•vMlgll&r M8mb8rBhlp Subserlptlonts 8ra r81)•wa)￿ 8nrwlly on ¥ rolllng 12 mothhly ba816 - Evenl Regisirallon and Exhlblllon F•è& rthfv•d h advqnce of the e￿nI iaklng plac8 - R•$lrkiod Gr8nts Rocdved that wlll not ba ulllW Lmlll fuiuro p8rlod8 19 R•••rv B•linc• at Trnn•lor from General R••¥rve In Y￿r Incom• In Yoar Exp•ndltur• In Y•*r B•l•nc• at 31 D•cemb•r 2023 Mov•mgnt lft Y•ar 202 R?$trt¢led Fund relallng to Qlobel¢$ Rg1e4rch Re8trfcteQ Fwd r￿8￿rt9 lo The Gfve CM6tmas Ch8hnge RgslrfGt8d FL￿d rd8tlng 10 D1•bPl￿ Wellnes$ Day HaTI*poDI D¥•ign818d Growth Fund General Rg$oTr• 253.613 21.974 12Q4.9)81 18.8851 48,710 13,309 48,710 21,974 8,085 2 50197J 1.641499 855 067 2 243 742 Balance al 1 January 2022 Tranil•r from G¢n*r41 In In¢om• lo Y•ar Exppndltui• In Yoir Net M0￿ment In Y•ir 8•l•nGO at 31 Drt•mb•r 2022 Y8•r Flestrfctgd Fund relats'ng to Olabetes Research Roiirtctad Ftsnd relaung to Th8 Glve CM8tma$ Chalerye Resirltled Fund Tei4Vng to Dlabet88 Walhes8 D8y H&rUeFwI D8slgnated Growth Fthd Gener81 Re8eNo 43,319 143,3191 123.0421 15CM)I 23,042 500 150,LJJO 114,3771 15001 1150,QOQI 8,685 110D.OLbJl 1713772 1063 490 2.801975 2510640 DI￿n￿ 2023 the charty partlclpated kn the Blg Gfve Chfi$lm&$ Chal8TvJe 202310 ra188 fvnd8 for8 Pump Prfmlng Rasearch Grsnt. Th& funds In the y88rwas £21,97412022 E8.e88}. llurtyi 20¥J th6 tholity received 8 £131,155 or8ntfrom Dlab81e$ Wellnes$ Nth￿rk Sweden for re¥eorch of which £48,710 ￿11 be $pÈnl In 2024. In 2020 Thg trustsas deS￿n￿led £1S0,LYJO lo supwt Ihe grth￿h aTrJ ￿￿er8￿[Call0n of 8cllvthes, Ihis was no k)noor requlred 4) 2022 8nd revefied lo genergl r8swve. Nel A888ts by FIKKI Unrotstrict8d Ro8trfct¢d Tothl Tanglbje As8et8 Cut¥ent As80ts Current Li8bllftles 12,175 2,625,284 393.717 2 243 742 12.17S 2,696.988 393,71 2 314 426 70,684 70.684 48 Dlabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2023 20 Paymonts to Conn•cted Charltlos Nature of R•latlon$hlp 2023 Connectsd Charlty Nature of Tran6actlon$ Total Balaneè at Tothl 8alan¢e at tr8nsactlons tha y#ar ènd tr4n#actlon$ the yearend In th& yèar In th• yèar Dlabetes Research and Wellne$¥ Foundation Inc. 156,408 159.771 Management charges in rÉlation to the shoring of artSdes and staff. This grantwas made to 0SSiSt with the funding of the As50fAatKin's awafenesB and edueatlonal prograrnmos. As50clation P0￿r La Recherche Sur La Diabete 200 Natur• ol R•latlon•hlp• 1 Dlabetes Research and WellneJ8 Foundation In¢. l¥ rJ)mpletely Separate and Ind?pendenl with no legal connadon5, but Mr. John Alahouzos on Board of Truslees ol the a860Ci8ted Charity in the United Stale8. 2 Associab"on Pour La Rechefchè Sur La Dlabettr 18 ¢omple￿Y 8eparats and Indèpondent ￿*th no lèg81 eonneclfon$, bul Mr W.M. Gretsthel and MrJ. A8h¢uzo$ ￿t on the Board of Trust608 Qlthe 88BQCiated charity In FrJnc&. Further detall8 rtyordlno tho rela￿OnshIp can b& found in the Tru8lees ReJx)rt. 21 Fln¥ficlal Commltm•nts Th• charlty ha8 finandal commitrnents ¢1 £404,S1712022.' £621.7751 lor grant8 aUthorfB8d but not accru8d 8B oxp•ndtturo for th8 year ¥nd8d 3108comb8r 2023, a¥ they arts 8ubiect to the Teciplentfvirilllng certain ¢ondltions. The amounts p8y8ble 8re a8 foll¢XY. 2023 2022 Poyabla In 2023 P?y8ble In 2024 Pay&bl8 In 2025 381.522 218,ooe 22,247 382,270 22,247 22 Op•rntlno L•a8e8 At 31st Decemter 2023, the charty ha8 comrnltrnents under operating lea8es a8 foll¢M'. 2023 2023 2022 2022 Wfthln ona Y￿r lo Five Yoars Withln one Year Two lo FSve Yoars Land 8nd Bulklln98 Otr•rAs8ets 24,950 2,433 26,932 1.852 28,000 2,940 21,e33 3,948 Totsl Tle Charftys offlcè th80 commenced on 31st January 2023 with a term ofthree years and a d16countsd period of the Nrst three months ¢urfng whlah th8 rent payable was £nil. 23 R•¢on¢lllatlon of Ngt nthvern•nt In Funds to Net Cmh Flow from O￿Ta￿￿9 ActivIt￿B 2023 2022 Net Movamènt in Funds. SurplusllDèfficit) Add back Dépreciation Charge Deduct Intèrest Ineome Shown irt Invssllng A¢tivKiè& Decrea89 (Inc￿850> in Debt In¢￿Se (Decfeasel In Credlto Nel Cash used in OperatSng ACtivI￿e6 1196,2141 3.516 129,0571 397.220 10,948 164518 1284.595) 2.717 12,7041 le83.7741 77,190 1005 $46 24 h1•mbers' Llablllty The FoundatK)n 18 a company Ilmlte(l ty guar8ntee. In tho av•nt ol W1￿1ng up, the 5 m•mbers' Ik4bility is limited to £1.