2022-12-31-accounts

Diabetes Research and Wellness Foundation IA Company Limi*d by Guarants&l Charity Number: 1070607 Company Number: 03496304 Flnanclal Ststsments For the year ended 31-Doc-22

Diabetes Research and Wellness Foundation INDEX Page Report of the Trustees 1to24 Independent Auditors, Report 25to28 Stat8ment of Financial Activities Balance Sheet 30 Statement of Cash Flows 31 Notes to the Financial Slaternents 32to40

Diabetes Research Wellness Foundation Diabetes Research and Wellness Foundation (DRWF) (A Company Limited by Guarantee) REPORT & FINANCIAL STATEMENTS For the year ended 31 December 2022 Registered Charity Number.. 1070607 Cornpany Number: 03496304 on Megan, who has Type I diab8tes. conqu•F•d h•r fgar ofheights by ab$elllng th• Splnnaker To¥v•r, Portsmouth to ralse •w•r•ness and fvnds lor DRWF. Here she is wlth Dad, Slmon. who has type 2 di&bete¥. THANK YOUI To everyone who has donated. volunteered theirtlme. or undertaken 3n activity to support us. Your contribution makes all the difference, meaning that we can carry out awareness, educational programmes and rese2rch funding 3ttivities to ensure that people with diabetes are 'Staying well until a cure isAound... THANK YOUI for being part of a powerful community who are intent on investing in a brighter future fof all people with diabetes #StrongerTogether

Dlabete51e5e4￿1 { WeUnèssFOundaD Message from our Co-Founder & Chairman - Michael Gretschel After two very challenging years, we were keen to resume our community activities, with the year seèingthe return of our residential Tl Family Camp, the flrst slnce 2019, as well as continuing our virttjal Camp in the Cloud. We were able to run three Diabetes Wellne55 Days in the South, Midlands. and Northeast. and whilst all of these activities were well-attended, there was still an understandable nervousness about coming together after a prolonged period of isolation, There is no doubt that the whole nation has been affected by the pandemic, but It W35 ar8uably a more challenging time for p￿pIe living with diabetes and other long-term conditions. It was wonderful to be able to reconnect and renew ovr support in person. to See familiar faces and meet new friends from 3cros5 the dlabetes ¢ommunitV sharing stories of hope and detemilnation. Whilst we started the year wlth a renewed enef8y, it was clear that there would be ongoing challenges. Our hèarts went out to the people of Ukraine as war was declared in March, and we were pleased to be able to loln forces wlth local groups by making a modest contributlon of wam clothln& diabetes awareness items and hypo treatments. As inflation soared and the cost of living rose rapldlyi It was clear that we would have to remaln adaptable and flexible In our beneficiary programmes. In times of financial uncertainty and pressure. it is often people livlnÉ wlth health challenges who are impacted the most, so we were keen to ensure that we continued to meet the most Important needs. The fundralslng landscape remains very challenging and whilst we endeavour to navigate these pressures, we continue to focus on diversifving our income streams to ensure that we are robust and fit for purpose and contlnue to make a difference to the everyday lives of people with diabetes. Relying almost entirely on voluntary and fundraised income. none of our work would be possible without our amazing donors and 5UPPOrters who make us what we are. We are truly Brateful to every indivldual who has contributed to the continued 5ucces5 of the charity. helplng us to ensure that people with diabetes are 'Stoylng well until a cure islound... Finally, as we approach our 25 ?nniversaryyear, we must thank our staff, advisory board member5 and volunteers. It 15 because of the hard work, commitment, and tenacity that we have been able to help more people than ever before. Thank you. Mlke Gret$chel March 2023 TRUSTEES ANNUAL REPORT FYE2022

DièbotÈs Researth E* Wthe55Foundwon Report of the trustees for the year ended 31st December 2022 The trustees are pleased to present their report and message from the Chaimian tU8ether with audited financial statements for the year ended 31 December 2022. The financial Statements comply with the Charities Art 2011,. the Companies Act 2006,. the Memorandum and Articles of Associatlon and are prepared in accordance with the Financial Reporting Standard applltable in the UK and Republic of Ireland IFRS 102 Charities SQRPI (effective from I" January 20151. Our purpose, aims and activitles The objects of the charSty are.. To assist in the relief of persons with diabetes and any similar or related dlseases or conditions To ralse publlc awareness about diabetes and any Similar or related dlseases or conditions, thelr incidence, causes. treatment. avoidance. and relief The focus of our work Havlng had two years of very little communlty interactlon over 2020121 due to the pandemlc. it W35 heartenlng In the early part of 2022 to See an initial surge of interest in returning to in-person events and activSties. This was somewhat 5hort-Ilved however, due to the increaslng cost of living with rapidly rislng inflation and soarin8 energy prlces, as well a5 a groundswell of support In response to the Ukraine war. Whilst our initial focus was understandably on stabilislng our financial position having come through what has been descrlbed as 'the perfert storm,. it has been upperrn￿t in our minds that financial uncertainty, rising costs, loss of jobs and increasing poverty all have a sl8nificant effect on both ph￿ICal and mental health. Even more so when living with a chronic long-term condition, such as diabetes. We saw numerous new5 articles and reports durlng the yeor about the significant increase In numbers of people needlng to use food banks, with an upward trajectory of people not being able to accèss healthy or nutritiousfoods. Healthy eating is important for everyone but especially so for people living with diabetes as It Is central to maintaSnin8 blood 8lvcose control in order to reduce the risk of compllcatlons. Some of which can be debIl￿atIng, life limitin8 and life threatenlng. Oeprivation is assOCl8ted wlth higher levels of obesity and physical inartNity which can negatively irnpact on all aspects of health and increase the risk of Type 2 diabetes. Financlal Uncertainty 3150 increases soclal Isolation and auses 5Sgnlficant stress whlch can lead to depresslon. All of which can impact on blood glucose levels,. diabetes managemerst and ultimately lea(1 to poorer health outcomes. Our priority in 2022 was to remain visible and accèssible to everyone affected by dlpbetes that Treeded our help. Supported self-management of di3bete5 is central to reducing the risks asso¢lated with complicatlOP5 and therefore our aim was to do more to understand need 2nd provide inforn)ation and educational support pmgrammes that provide the practical tools to support and encourage a pro-active approach to good self-care. We consider that thoge with the greatest knowledge of their condition will have a better understanding of the disease and will be better equipped to have an impact on the progression of their diabetes and any associated complications. Our Diabetes Wellness activities, both in the community and virtual, provide a great platform for meeting people sharing similar health concerns, making new friends. and building peer support networks. all of which sèrve to reduce isolation and enhance both the physical and psychosocial management of diabete5. A much-needed resource In TRUSTEES ANNUAL REPORT FYE2022

DI1￿85A￿search S5 these drfficult tirnes. whilst the research we fund continues to Improve our understanding of diabetes, it's treatment, management, and cure #StoyingWellUntiloCurelsFound.. Demonstrating public benefit The tnJstees confirm that they have referred to the general guidance set out by Charlty Comm15sion on public benefit. The trustees are satisfied that the Charitvs activities mèet the principles of public beneflt, defined as providing an identifiable benefitls to the public, or section of the public, and know of no detriment or harm that may be caused 35 a result of these activitie5, which are dearly set out throughout thi5 report. Volunteers As a small team éellverSn8 numerous activities, we rely on the support of volunteers who participate by helplng with administratlve tasks In our office: dèlivering diabetes awareness and information materials; undertake user Snvolvement exercises to help steer and develop our programme activities; support our educatlonal events and communlty lundralsing programme or sit on one of our expert panels for research or Information revigw. The number ol volunteers fluctuates each year but 15 crucial to helping us spread the word about the work we do and to support local and n8t5onal community fundraising initi3tive5. Aside from our Trustees, we have an Editorial Advlsory Board and a Research Advisory Board. These are panels of diabetes clinicians and sclentists, and other relevant professionals, all of whom offer their time and expertise voluntarily to ensure that we meet the high standards required of us through our Association of Medical Research Charities IAMRCI accreditation and our ¢ommltment to produclng cllnically evidenced health and soclal care information. We wholeheartedly thank all of our volunteers for thelr tlme, expertise and commrtment whlch helps us raise awareness to the charlty, maxlmlse Income and maintain high standards of work. Measurlng Impact We use a mixed methods approach to monitor and evaluate our actlvities In order to ensure that they remain true to purpose and achievè desired outcomes. Stakeholders and beneficiaries are Involved in these evaluation processes to ensure the continued relevance, quality, acce55ibility, and effediveness of actlvltles. We also undertake Independent evaluation with specialist partners for speclflc projects where Impartial opinion and/or additional expertlse is requlred. We keep people with diabetes at the heart of what we do. Beneficiaries and supporters are Involved in numerous ways to ensure that our support and resources are relevant, accessible and meet needs, helpin8 to steer our research prlorlties and programme activities. Activities & Achievements in 2022 Awareness, Information & support INFORMATION REACH: Our direct mail pio8ramme played a key part in our ¢ornmunication5 strategy during 2022. enablinB us to stay connected with key audiences who do not routinely engage with online channels. We distributed 442,040 campaign packs in 2022 an increase of around 13% on the previous year. The health inforniation contained within each campaign is targeted at beneflciarles who could act on the information. either in a preventative way (type 2 diabetesl or to inform and support those living with diabetes lall typesl, in their self-management of the condition. Whilst maintaining relationships with existing supporters of our appeals, we also reaihed out to higher volum8s of prospective beneficiaries and supporters of the charty during 2022. We had an average campaign response rate of 7.3% across 4 streams resulting in over 32.170 responses from across the country. We know from experience that it is likely that many more opened and read the appeal bLrt Chose not to make direct contart with us at that time. TRUSTEES ANNUAL REPORT FfE2022

Diabere5 Rèsear£h Historically, we have seen numbers of people respond to communications that have been distributed many months, or even years, before as they have held onto the inforn)ation provided for future reference. These campaigns also art a5 a stewardship tool, helping us to stay connected with long-standing sUPPOrters of the charity. Health Unlocked Forum- The DRWF Diabetes forum within Health Unlocked provides a 'safe space, for people with diabetes to share their experiences, gain support and make a difference to others too. In 2022. the volume of members increased by 33. meaning that all time membership increased by 6.5% to 6.042 in the year. The volume of 'active' contributors declined slightly from 2021 by 9%, at 422, with people spendlng an average lime of 04.26 minutes on the forum. Thls had increased In the year by almost 14°A. Our forum erlables people to acce55 online resovrces and too15. as well as the 5UPPOrt of others experiencing similar health issues. all of which has been shown to improve health outtome5. WEBSITE: Wè launched a new webslte In 2022 and expected that there would be a lull In trafficlengagement for a period of time, however this did not begin to rise again when expected. There are multiple reasons for this. Firstly. 3 Google algorithm update at the end of 2021 made DRWF drop down the search iankings a little. Thi5 was c105ety followed by a more major update to the Google search algorithms at the exact time that we launched the new 51te. These two things happening simultaneously has proven challenging to our SEO. also affecting our Adwords campalgns. Therefore, webslte page views were éown 24.5% over 2021 at 314,760 and the total number of unique vsers was down 32.29% at 182,410. A lot of work has gone into improving our SEO and in getting Adwords working more effectlvely, and traffic Is increasSng agaln but it is a gradual increase which is somewhat due to the resources available to us at this time. These are disappointing figures for 2022 having seen a sianificant upward trajectory in 2020, with a natural decline In 2021 following the spike of online activity dye to the pandemic, and plan to rect￿ this situation in 2023. LIVING WITH DIABETES PODCASTS & VIOEOS: We continued to produce our Livlng with Diabete5 podcasts in 2022 which provide5 another channel through which to access interesting and educational diabetes content. Whilst these channe15 are still very muth a work in progress, we have had reasonably good engagement during the yearwlth 2,659 viewslllstens. We aim to develop these channels during 2023. SOCIAL MEDIA CHANNEL5: In 2022 we continued our efforts to raise awareness of our activlties and services to more people through soclal medla campaigns with most en8aBement being seen through our Facebook page. Our sponsored Facebook content reached over 2.4 million people, up 45% over 2021, and had 7,780,382 impressions. This increase was achieved with an identical budget in 2022 and 2021. Our Tweets received 209,9￿ impressions and our Instagram page reached 91,403 people, up48% Dver 2021. DIABEfES WELLNESS NEWS: We distributed 103,471 copies of our newsletter, Diabetes Wellness News, to sU￿CrIber5. healthcare professionals and regular givers. This is a IO% decrease in the circulation numbers of 2021. Much of this redtjction is related to deceased notlflcations recelved from subscribers in the year due to the demographic of this channel of sUPPOrt. The newsletter is distributed to onnual subscribers and on a complimentary basis to healthcare providers who share the information with their patient communities. On a quarterly basis the CiTculation is boosted as we focus on the research element of our work and send a copy to our regijlar givers. It is difficult to accurately predict the true readership of the newsletter but through anecdotal evidence, it is much wider than those who have specifically requested to receive it and is seen as a stewardship tool to maintain engagement with a variety of different supporter and beneficlary audiences. We intend to change the frequency from monthly to quarterly distrlbutlon in 2023 as we work towards meetlng the needs of existing supporters of this resource, as well as take DWN online. TRUSTEES ANNUAL REPORT FYE2022

that￿￿esearch Wel￿￿￿%Foun￿è00n Quality in Care Diabetes - award winning Diabetes Wellness events Qic Diabetes structured education aims to provide pwple with diabetes wlth the knowledge and confidence to seEf-manage a long-term condition effectively. The offer of struclured education across the country ha5 improved over more recent years. However, the rates of attendance are still very low and vary widelv. For the past 23 years, we have provided an annual programme of Diabetes Wellness events. We work wlth dlabetes, and related healthcare professionals to facilitate workshops that provide relevant, up-to-date, evidence-based information covering all aspects of diabetes and related health. Delegates choose the sesslons and talks that they attend meanin8 that they create their own agenda for the day, Improving engagement and supporting better outcomes. These events bring together a wealth of information, expertise, and peer support under one roof, with the aim of inspiring and empowering people with diabetes In their self-care. Our Dlabete5 Wellness Days were acknowledged by the Quality in Care lQiC} Oiobetes awards In 2017, when we won the Judges Special Award category. The Judges commented- "The Dlabetes Researth und Wellness Foundatlon h¢7ve put tooethera brllllunt educotltsn supportproqramme wlth excellent outcome& The events are cleorly u5erfocusedi providlnq an opportunityloipeersuppor¢ and re- enguglng those user5 who hove mi55ed out on u strurtured educotlon. The progromme oAlers huge volye to luture users ondhas great potentlul to reoch otherareus olthe UK." Network Rail - Wellbeing Wednesday In July 2022, we were invlted to host Network Rall's Wellbeing Wednesday programme, whlch saw 805 live and on-demand listen5 to our Intervlews and S- minute dlabetes video tlps. •4 Diabetes Wellness Events in 2022- In 2022, we were able to return to in-per50n events, hosting three Dlobetes Wellne55 Duys in the South, Midlands and North-Ea5t, along with a resldential Diabete5 Wellness Famify Comp for familles of children wlth type I dlabetes, and a virtual Tl Cump In the Cloud. 355 Diabetes Wellness Days- Three events held in the South, Midlands and Northeast of England enabled us to provide educational sUPPOrt to 355 people living wlth type l and type 2 diabetes. These events provide an interactive programme of workshop5 and talks, grouped around a vibrant exhibition hub where dele8ates can meet healthcare and industry partners offering essential diabetes diagnostics and other produrts and support services. They also provide a wonderfijl opportunityto talk to diabetes and related healthcare professionals about 311 aspects of life with diabetes, as well as make new friends and connections. All of which empower sell-managenient and improve health outcomes. TRUSTEES ANNUAL REPORT FYE2022

) Dt4teies ReseJr(h Er Dlabetes Wellness Famlly Camp Our first resldentlal Camp since 2019. We recelved 37 lamily appll¢atlons1134 Indlvldualsl and had to close the online application process early due to demand. We had 60 individual places avallable and following triage, offered 62 places to 18 families. Eleven famllies143 individuals) remained on the waitin8 list. All families were offered places on the Autumn virtual Camp In the Cloud. The feedback from attendees was overwhelmingly positive and we received essential critique as to how we could improve the parental discussion se55ion, wlth more structure and smaller group sizes. to Steer our next residentlal Camp offerlng. "I goined time to be with myfamily without hoving to constantly think aboutfood- carbs, quontity, gluten/non gluten." -1 mode lots of newfriends with diobetes which is importont to me because sometimes Ifeel like the odd one out. We relaxed Fnto camp ofter o very short 5poce of time, ond we monaged to reconnect as o fomily but genuinely chatting to other caregivers, mums and dads det71ing with the some things ond being able to lough about it with people who reulty know what you re living through. We ollfeel completely refreshed and less overwhelmed and just not so alone.- TRUSTEES ANNUAL REPORT FYE2022

Dlabetes ResEèthfF lllnessFwDtht?L brts "Finding Someone else who understands whot you are dealing with. Developlng friendships with like-minded people. Listening to advice ond supportfrom other familie5." Hopeful Apprehensive Feellnis before attendln Camp,.. Excited sÉressed Alone BorcLI Uncertain Isolated Curious Angry Lonely sad Tired Buml Scared Happy Anxious ,.,, V¥4PI D&spY'•l? Positive Worried Unsure Overwhelmed rJity&nf Positive Proud anxious friends Th.Ilrod Brave connected Energised FeelSn8s zfter attendlni Camp... Loved A¥'t¢Med appy relievéd Grateful Lucky Satisfied Thankful ' Amazing C31 •y¢￿T.￿L rth￿Jttett Ew SensÈ t)xhilLlSted Ecstalir. SadExcited Greal liJr)Emolional family R•Jir.IpJJlod LJLwl Joyful Awesome Tired Relaxed "Refreshed Opiiinis&lt Hopef TRUSTEES ANNUAL REPORT FYE2022

.") Ots￿*S￿esearth Virtual Camp in the Cloud 135 Virtual Camp was introduced during the pandemic, and due to its success and accessibility, we have decided to keep this going 311 the while the￿ is an appetite for attendance. We had onticlpated that we could accommodate between 12D- 150 online attendees and were overwhelmed with the initial response, which saw 55 families1198 individvalsl register their interest. The nature of an online event increases attrition rates. Thirty-nine 1391 families went on to complete a full application.. 37 familles1140 individuals) were offered places; 35 families1135 individualsl attended on the day. A full proBramme of online artivities was offered, with a box of arts and crafts, and other materials. supplied beforehand to make the day as interactive and fun as possible. The final session of the day gave the paTents an opptsrtunity to relax 2nd discuss diabetes as a sm311 group along with DRWF staff and participate in a quiz. -my child wos diogn05ed during covid, so it hos been o hard lonely time.- Feedback was overwhelmingly positive. with families Stating that covid-19 had been a huge challenge, and incredibly isolatin8 particularly for those that were dia8n05ed In 2020121. "My doughter wa5 diagnosed with type one diobete5 in April 2020 at the beginning of the first lockdown. She has missed out on the opportunity to meet other children with her condition os the hospitol connot run its normal family events. As o family only one parent Ct7n ottend hospltol oppointments with Ophelio which is not idet71 when she wants both parents there to SUPPOrt her. She storted school in September 2020. Although the training w05 brilliont It s been chollenging not being able to meet with stoff ond core givers properly. All my children have experlenced disruption due to Covid. The eldest three hove missed o signlficunt omount of School und my baby hod been unoble to go to baby groups.- "It W05 voluoble to know there are otherfamilies out there dealing with the 5Gtme condition. We enjoyed completing some of the octivities together. My daughterfelt special receiving the gifts in the box. My husbond and I found the porent tolk useful Gnd interesting. rhe comic book activity and coding were greot. The bingo wa5 0 good ice breaker octlvity." Diabetes Professional Care- DPC Dlabetes Professlonal Care For the 7 consecutive year, DRWF was the registration sponsor of Diabetes Professional Care IDPCI, an event that provide5 free to access CPD accredited education for healthcare professionals delivering dlabetes care. Almost 5000 healthcare professionals, from acros5 the primary and secondary care spectrum. attended the event over the course of 2 days, benefitting from an educational programme facilitated by multi-dSsciplinary teams. The event was opened with a keynote session from Professor Partha Kar OBE, National Specialist Advisor Diabete5, NHS En8land and Professor Jonathan Val3bhji, National Clinical Director for Diaberes and Obeslty, NHS England and Improvement. We ran pre and post event surveys with registered healthcare practitionert to gauge awareness of DRWF and the information resources that we have available free of charge to support onward diabetes care of pegple with 311 types of diabetes. Of all registrations. we had a 3% response rate 1147 respondents), whrch has helped to inforni our fijture marketing and dislribution plans of our health and social care information. TRUSTEES ANNUAL REPORT FYE2022

WellnessFouad4ti0 Research Funding Programme Each year, we issue Calls forApplications in respect of our3-year Clinical. Non<linical and Pump Priming awards. DRWF Fellowships provide the necessary funding to support Early Career Researchers IECRI which 15 Vltally important to ensure that clinical and scientific talent stays and develops within the diabetes medical research community. ECR'S represent a young and diverse research population, and provide a constant flow of talent, new ideas and new skills. Some of them will go on to be the senior dlabetes researchers of the future, so with very few funding awards available to this vital community, the DRWF awards are lucrative and well positioned to attract the bèst and brightest young researchers. Our Pump Priming Stream is a proof-of concept funding channel, which aims tt) produce translational pilot study data that goes on to leverage higher value. longer term fundin8 from other organi5ations to take the research conducted to the next level. The DRWF annual fundin8 round is offered through open competltlon, and a5 such. enable5 funded researchers to access sUPPOrt for both Sndirect and direct costs of research via the Charity Research Support Fund ICRSFI and NIHR Clinical Research Networks ACORD agreement. Institutional and discretionary awards are available vA)en funds allow. Contrart funding of key personnel wlthin the DRWF Human Islet Isolation Faclllty at the Churchlll Hospitsl. Oxford is subject to proposal and revlewed on a multi- vear rolling contract basis. DRWF Is a member of the Associatlon of Medical Research Charltie5 IAMRCI, a membership body repre5entlng the leadlng medical and health research chartties who dellver high-quality research that saves and Improves Ilves. Workln8 wlth member charlties and partners, AMRC alms to support voluntary sector effectiveness and advance medical research by developing best practice, providin8 information and guidance. Improving public dialogue about research and science, and Influen¢lng government. As a member, we subscrlbe to AMRtrs criterla for the use of peer revlew for all¢xatlng fundlng and support AMRC positlon statements on the payment of Indirect ttjstsln universities and the use of animals in medlcal research which sEek5 to replace. refine and reduce the use of anlma1513Rsl in research. We operate a ri8orous peer review process by which our Research Advi50ry Board IRABI, clinlcal and scientlflc experts in the fleld of diabetes and related health, assess applicatlons and reports to ensure that only the highest quality and most effertive research, carried out using good or best practice methodologles, receives DRWF funding. Claire Levy- Ilvlng wlth T2 Dlabetes "Fundlng reseorch into new treatments and new technologie5 has tronsfvnxed the lives of people living wlth allform5 of diabetes, including myself as someone with Type 2 Diabetes. DRWF hasfunded some omazing research over the10st 24 year5, made possible by the very genemus donation5 of oursupporters which ha5 reolly odvanced our knowledge of the different types of diabetes and how to manoge ond treat it. We will onfyfind o cure through research ond your gift could moke oll the difference.- IESEARCH 10 TRUSTEES ANNUAL REPORT FYE2022

j Diaè4t+s A&5¢4rth& WeItn￿ssFDuryJdth 2022 Professor David Matthews Non-clinical Fellowship We received 8 Pre-applications for fundin8, from which S full applications were submitted and subsequently invited to interview. The Board of Trustee5 reviewed and approved ihe RAB'S funding recommendation In December. Dr Ana Virtoyla Garfield. University College London, £128,663.95 over 2 years. Understonding how diobetes und hyperglycaemlu causes cognitive decline. dementio, ond obnormal brain strucfvre. An Inteorated genetlc epidemlological ond deep phenotyping approach to disentangle pathwoys nd interployoAriskfarto "Dementio Is one of the most feared diubetes complication5. While risks ore elevt7ted In people wlth diabetes, glucose lowering trfto15 ure disoppointlng, Mendellon rondomisQtion is Gr genetic tool which con help uncover true cousol relationshlps, 05 genes ore rondomly distributed ot birth and not influenced by external riskfactors. Using thi5, 1 show that diabete5 Itself is not Causolly reloted to dementia. I now wont to use thi5 tool to iclentify whlch diobetes relotedfoctor Is the true culprit, In lorge dotoset5 which include meosures of cognition, brain structural domoge ond dementiÉ7. There ore four potential explonotions.- ij processes underlying diobete5 e.g., Insulin reslstonce, il) t7550cIDted metabollc disturbances. e.g.. amino acids. IIAJ ossocit7ted ri5kfoctors e.gpl blood pre55ure (BPJ, ivj ri5kfoctors Upstream of diobetes e.g., obe51ty. By identifying true COLts01 determinonts, I con then pinpoint Interventions to be tested in clinicol tri915 to reduce dementia rtsk in diabetes. Islet Cell Research & Transplant DRWF hos made a considerable contrlbutlon io the funding of islet cell research and transplant in the UK and around the world. The DRWF 4uman Islet Isolation Facility at Churchill Hospital. Oxlord plays a plvotal role in providin8 islets for research and transplant as part of a natlonal treatment programme. the clinical element of which is funded by the NHS. C)X [-. fiRf) Three personnel are funded withln the facilwty laround 30% of facility staffl.. Lab Manager Deputy Faclllty Manager (post doc researcher) Islèt Transplant Administrator Durlng the year. we renewed our commltment to the Deputy Faclllty manager post, offerin8 the contlnuation of I yearfs funding. Ordinarlly, these p05ts are funded for between 3-5 years, giving continuity and stability to the indlvidual post holders and wider facilitylteams. This IS vitalty important to ensure sustainability of expertlse withln the research group, given that this facility work5 on rotation to1s013te islet cells for human transplant, as well as supply i51et5 for research across the UK and Europe. On this occasion, and as the post was vacant at the tSme of review, we erred on the side of caution given the ongoin8 challenges of fundraising activity. By making the commitment. the university were able to proceed with recruitment and we intend to revlew the ongoing financial commitment in 2023 when the post has been filled. Impact report from the Director of the DRWF Islet Isolation Facility Churchill Hospital, Oxford by Professor Paul Johnson Dvrin8 the pandemic. the University closed many of its research facilitiès for various periods of time. This limrted research activity, but the team continued to be research attive whenever it Was POS5ible. Whilst official lockdown TRUSTEES ANNUAL REPORT FYE2022

..) DiibotE5Re￿rth£1 restrictions had become less robust in late 2021 and into 2022, many hospitals and research facilities malntained their own restrictions to support their recovery from the significant impact of the pandemic. The Oxfo¥d tèam tontinues to be one of only 3 clinical islet isolation facilities in the UK lone of only 2 in England and Wales) which remains on an alternate weekly isolation rota with Kings in London. Between April 20213nd Marth 2022. the team undertook 23 clinical islet allo-isolations from a wide range of pancreas donor5. With 64% of Isolations achieving transplantable yields with 30% of isolations being distributed to transplantation to the islet transplant centre5 around the UK. The outcomes for this 12-month period match internatlDnal standards. The clinical islet transplant programme ha5 expanded In this time and 15 now transplanting for the Bristol catchment area, as well as transplanting islet patients for the Royal Free. A new satelllte clinic in Leicester is also planned. The NHS-commissioned total pancreatectomy with islet auto-transplantation ITPIAll programme for chronic pancreatit15 continues to develop. Islèt i5013tion for these fibrotic pantreases is difficult but the team has achieved good results and have also been evaluating some novel modifications to the isolatlon protocol, which they hope to promote internationally. Clinical outcomes are encouragin& and they are now in the process of applying for NHS-commlssioning for TPIAT in children. which Oxford is well placed to provide. The DRWF Isolation Facility in Oxford continues to provide human islets for research to a network of type l and type 2 diabete5 researchers around the UK. The tearn has now provided IS.1 million islet equivalents IIEQI (the International standardised way of counting Islets) from 86 islet preparations that have resulted in over 46 peer reviewed research publications. A new initiative with NHSBT, the 'lncreasing the Number of Organs Avoiloblefor Research, IINOARI is now established enabling organs from donors with diabetes to now be retrieved routinely from across the UK for research purposes. The Oxford DRWF Islet Isolation leads the 'lslet Platform, for the related Quality in Organ DonatSon IQUODI wlth responsibility for isolating and distributing islets for research from these rare pancreases. In November 2022, DRWF released a short fllm sharln8 impact storfes around diagnosls and life wlth Type l and Type 2 diabetes, showcasin8 the dlfference that an islet transplant make5 to quality of Ilfe and Independence. Professor Johnson contributed to this film along Wlth an islet transplant recipient. The fllm can be vlewed at How we raised our money In 2022 Our approach to fundrai5ing- The Trustees are aware of their responsibllity and accountability to ensure that the charlty fundraises legally. re5pon5ibly, and effectlvely. Our plan for 2022 was to maintain focus on building resilience and sustainèbility for the future through succession planning, diverslfication of income streams and delivery of purposeful programs that continue to meet the ever- changin8 needs of people wlth dlabetes. In the hope of returning to more nomal levels of artNity in 2022, we set our slghts on an ambitious income expectation to support dlver5ification of our fundraising attivities. This is key to 5UPPOrt future sustainability. Whilst we had hoped to see pre-pandemic behaviours return in 2022. the Ukraine War. rising inflation and cost of living challenges, had a big impact throughout the year. These thallenges affected our actual income in the year which was £1,765,756 a shortfall of 4% on our budget expectstion of £1.836,508. However, income was 5% hiEher than FYE 2021. This was mainly due to high levels of legacy bequests received In the year and an increase of reach via our dirert mail programme. 12 TRUSTEES ANNUAL REPORT FYE2022

OknbÈiE5Rp5eèrthb Wellne55FrpJndatson A¢tual Income by thanhel 2022 OMlw• Corporate Partnerships: We do not endorse produrts, but we wlll support initialives that increase awareness to DRWF and our activitie5, and where there is èn appropriate messa8e, produrt, or 5ervlce for people with diabetes. To this end, we have worked to explore meaningful partnership and corporate sponsorship opportunities, where there Is a synergy In mission, vision, and values. Any potential partnership Is assessed for feasibility, compatibility with our own oblectives, and risk to ensure there is no detrimental effect to our reputation or fundraising potentlal. Robust risk assessment supports our desire to only engage in suitable and best value partnerships. Detailed discussion and negotiation ensure that the aims of l)oth partles are complementary and mutually beneficial. This malntains transparency and integrity in all partnerships. Professional Fundraisers: Whi15t we use the services of fundraising consultants, as and when needed, to advise on some of our activities. we dld not work with a professional fundraiser during the year. Commertial participation agreements are in place where necessary. YOU make all the differencel a tharity that e￿5t5 almost entirely, at this time. on voluntary donations and fundrai5ed income, we are always humbled and heartened by the support that we receive. Here is a snapshot of some of the community activities that took place in 2022 that helped raise awareness of diabetes, the charity. and its Se￿iCe5, a5 well as vital funds to support all of our charitable activities 13 TRUSTEES ANNUAL REPORT FYE2022

F) ￿￿be￿ t5Earth Er MEGAN MANAGED BRILLIA￿Y... Spotting the signs of dlabetes earfy could save lives. A young woman who nearly died from undiagnosed type I diabetes is campai8nin8 to save the lives of others by raising awareness of the symptoms while fundraislng for DRWF. Megan Jansen overcame her fear to absell more than 550 feet down Portsmouth's Iconlc Spinnaker Tower to celebrate the fact she's stlll alive after defylng a deadly compllcatlon from undiagnosed type I diabetes just over flve years ago. Megan hoped her participation In this challen8e would help to ralse awareness of the symptoms to save the lives of other young people and children. "Knowlng the 5ymptom5 of diabetes Is Ilfe5avlng and had it not beenfor the intenslve care unit teom at Torbay Hospital in Torquay I would have lost my Ilfe In 2016."warned Megan. 22. "I think DR WF has a great understondinq of how devostating o diagnosis of dlabetes can be ond their attitude towards wellbelng hos helped me become more confident in myself.. Simon Jansen, Megan's father who has type 2 diabetes joined his daughter in the absell for DRWF. He added: "l am so proud and grt7teful to have been 'roped In. to abseil the Spinnaker Tower to support my doughterf5 efforts to roise moneyfor DRWF. Megan said: "Dlabetes15 not just as simple as controlllng your glucose levels and DRWF has helped people develop heotshy relt7tionships Wlth their diabetes. The absell was exhilan7ting ond so importantfor me to constantly chollenge myself. Even more exciting was thot my dod chose to take up u ploce os well. especially 05 he is Ilvlng with type 2 diabetes.- -one more thing- please remember rfyou're struggling with your dlabetes reach out to DR WF ond make the most of the incredible support networks that they can provide. Do not letyour diabetes get in the way of whot you want to ochleve, whether it be a big obsell, a work gool or o personal lift gool. Living with dlobetes does not define you. Megan Jansen 14 TrUSTEES ANNUAL REPORT FYE2022

F.) Dkibetes Researth WEll￿55 Foundadon KATIE, BOOTS ON RUNNING FOR DIABEtES... In February halfterm 2022, shortly after his eighth blrthday, Eddie was admitted to the Royal Surrey County Hospital where he was diagnosed with Type l Diabetes. We'd been worried about him for a while as he'd he been unwell and lost a lot of weight. The diagnosis was a horrible shock to the whole family, and we Immediatelytried to work out 'why what when, and 'how'. The care we received that week from the paediatrlc diabetes tearn was incredible. We found ourselves on steep learnlng curve attempting to process how thls autoimmune disease affects the body, test blood glucose levels through finBer pricks and. learning how to deal with often scary'hypos and hypers,. We were taught how to give Eddie multiple daily insulin Injections {practi¢in8 on 8rian the Satsuma !). Once home from hospital we had to determine how to fit this care into Eddie's Incredibly artive life and we began the 24/7 juggle of man38ln8 exercise. food, stress, medicatlon, technology, and BG levels. Yw¥ QQF Eddle has been through so mL•ch. His flrst questlon whilst in A&E was'mummy, how long will I have this for7, The realisatlon that this condition wouldn't go away like a cold or chicken pox was something hard to breakto him. DRWF was one of the first online resources we found to educate ourselves on the practicalities of TID. Their mlsslon of 'Staylnq well untll o ¢ure lsfvund, resonates as this is how we choose to support Eddie is his day-to-day life. We are committed to makln8 Sure that TID won't ever stop him from belng involved In anything he wants to be part of. We not only support but want to be involved in future research and development that strlves to flnd a cure and before that, the more seamless management of diabetes. Eddie Is passlonate about athletics and bein8 active. He wa5 50 keen to get back to hi5 track sessions at the YounB Athletes Club after coming Out of hospital that I stood trackside with him in the dark. in the rain, throwing jelly babies in his mouth every time he ran past me. After 18 minutes of his first session back at Young Athletes Club we had to come off as he had a dangerously low 'hypo'. He cried, l cried. frustrated at how unfair'stupld diabetes, was but he went back the followinB week stron8er and more determined than ever not to let TID Stop him. Katle Boots. mummy to Eddle and London Marathon runner for DRWF 15 TRUSTEES ANNUAL REPORT FYE2022

Di4betesResearth WEUnp55FouryJailon DANCE FOR DIABETES, in collaboration with FunKidz Dance Schookhlldren In Portsmouth t￿)k part in collaborative event between DRWF and Danceschool Funkldz Dance Umlted. A fundralsing playground dance event auoss three schoo15 in Portsmouth ralsed more than £9,C¥JO for DRWF. The Danre for Diabetes event was organised by DRWF in partnership with Portsmouth-based Dance School Funkld2 Dance Limited, owned and managed by Samantha Collins. Throughout the month of May each participatlng school was glven a fun dance routine to learn from a series of videos. Thls wa5 done durlng school hours and worked Into lessons where approprlate: whllst being made available on school platforms to practlce at home. More than l.SW children aged between 4 and 11 years old Ischool years R to 61 took part ralslng a total of £9,209. All sponsorship monies ralsed were spllt equally between DRWF and the particlpatlng schwl. The partnership had five aim5: promote physical and mental wellbeing: develop new skllls,. nurture new and exlsting frlendshSps,' offer an Introduction to dance: and to ralse funds for charlty. Samantha Colllns and DRWF Head of Communlty Fundraising, rim Green, visited all particlpatin¥ schools to perform the dance in the playground alon8slde èll teachers and school staff. It was a fantastlc celebration of keeping artlve, collaboratlng with friends, and having funl Every partlcipating chlld recelved a certiflcate: with spedal class certificates bein8 awarded to th05e that demonstrated most Improved confidence: most improved performance: and highest-class fundraiser. Samantha said.. "A lot of children love doncinq but don't olwoysfind it easy tofit in wlth the structure of a dance school environment. In my experience donce 0150 come5 With a lot of addltionol costs such os costumes ondfootwear. I wanted to strip thi5 bock ond do something thot IS just about belng themselves, feellng comfortable. wearing their own clothes, and using theirfeetl An experience I feel gives children Such a confidence boost thut really help5 their development and sociol skills. "Working olongside DR WF is so important to me a5 It 15 ocondition that not onlyimparts myfomily dlrectly but uffects so mony of our children's fomilies too. Diobete5 15 0 lrfelong condition tht7t is something we don't 5peok about enough, so l om thrilled to be able to raise t7wareness ond fvnds by organising thls donceathon.- 16 TRUSTEES ANNUAL REPORT FYE2022

OiabÈte5 kn5eaKhEt WelknesSF￿Jh￿at￿ Fundraising Regulator- We are a leyy-paying member of the Fundraising Regulator and subscribe to the associated fundraising codes ol practice. The charity suppresses individual supporter records against the Mailing Preference Service, Telephone Preference se￿iCe, and the Fundraising Preference Service, which helps to ensure that we do not approach individuals who have expressly requested that we do not contact them. During the year, we were notlfied of 23 FP5 requests, which are suppressed from all contart, 9% hlgher than received in 2021. Com plaints: The charity has a publSshed complaint5 procedure, available on its website, and endeavours to respond to enquiries and complaints Wlthin the stated timeframe. Most contacts tend to be a reryuest to opt-out of chzrity communications by existing supporters and we rnonitor the basis on which people request this i.e., content of appeal, volume of contact; type of contact- method of contact to infomi our campalgns with the aim of educ5ng any perception of unreasonable intrusion, persistent approach or undue pressure to support. We dién't receive any complalnts about our fundraising practices during the year. GDPR and Data Protection: We are committed to proterting the personal informatipn and prlvacy of Individuals that we enBage with and comply with relevant legislation and codes of practite, whilst carrylng out our essential work of raising awareness of diabetes, providing informatlon and support. and raising fund5. Our privacy policy, published at drwf.or8.uk sets out how we capture, proce55. manage and retain personal informatlon. Flnanclal Revlew Prlncipal income streams in the year were dirert mail campalgns; regular 8lvln8 vl3 dlrect debit,. legacy Income and gift aid associated with voluntary donations. Income and expenditu￿ are monitored on a weekly bas15 Wlth bud8ets/forecasts adjusted accordingly. Income: Total income was £1,765.756. This was 4% lower than budgeted income l£1,836,S081 but an Increase of 5% on income recelved in 20211£1,686,0611. Voluntary donations including gift aid receipts at £812,809 was up by 13.5% on 20211£715,6711. Le8acy income, having been bud8eted for on a 3-year average (less l unusually lar8e le8acyl, was £808,983 which was 47% higher than bud8et,. 7% lower than received in 20211£868,6111. Expendlture: Total expenditure was £2.030,351 which was 9% below budget 1£2,235,9701, this was an increase of 7% on expenditure in 20211£1,900.4221. Atyear-end we had a deficit of £264,595.Thiswas 34% lessthan we had budgeted for1-£399,4621, 23% higher than the deficit recorded in 20211£-214,3611. Direct charitable expendlture wa5 81p in every £1 spent184p in 20211. Government Grants The charlty clalmed £43,319 from the Government's Covid Medical Research charity Support Fund IBEISI t0 51JPPOrt early career researchers. The charity made use ot the Govemment'5 Kick5tart Scheme to fund digital jobs for six months for 16 to 24-year-olds on Universal Credit. £4.912 was claimed under thi5 scheme. Investment Policy Under the Memorandum and Articles of Association. the charity has the power to invest in any way the trijstees See fit. The trustees, in order to minimise risk and having regard to the liquidity requirements of the charity, and to the reserves policy, have historically operated a policy of keeping available funds in a higher interest-bearing deposit account seeking to achieve a rate of deposit interest which matches or exceeds inflation as measured by the retail prices index. 17 TRUSTEES ANNUAL REPORT FYE2022

Dl•betÈ58esearch Weuness FoUr￿￿￿on The trustees have regularly reviewèd opportunities to Intrease investment return from short-term. easy access, options bearlng in mind the desire to ensure that we can react quickly to appropriate requests for additional research 5UPPOrt as they arise. The trustees are also conscious of on-going cash-flow requirements during a challenglns time where historical fundraising methods are raislng less income and where new methods of fundraising are being tested at higher cost. All thlngs considered, the trustees believe k appropriate to continue to explore investment opportunities as thev present thèmselves. Wlth a view to maximisin8 return on it5 deposits. With intercst rate5 rising Sn 2022, the Board felt it Important to consider whether there was opportunity to dep051t surplus cash into short-term. hi8her interest-bearing bank accounts to maximise return. To this end, the charity opened a CAF (Charitles Aid Foundation) Chartty Oeposit Platfomi account, provided by Flagstonè, which Bives access to around 80 notice and fixed teTm accounts with 20+ banks. The interest rates offered via this platform are better than can be obtained by the charity approaching the banks individually. Accounts creatèd on the Flagstone platform wSth onshore UK banks provide the same F5CS protection as If the deposit had been placed directly wlth that bank. An annual management fee of 0.225% of account balance Is char8ed. This platform will be set-up in 2023. Reserves Pollcy To safeguard the need for sufficient funds to cover on going management, administration, and support costs, as well as respond to further grant requests that might arise. the Board aims to maintain unrestrlcted, free reserves at a level that equals 3-6 months of operatlng and charStsble expenditures, which equates to between £474,894 and £949,788. Durlng flnancial year 2022. total expenditure was £2,030.351. Allowin8 for adjustments and forward research commltments, the charity's expenditures for financlal year 2023 are likely to be in the region of £1,899,576. At 31st December 2022, the charity held free ￿SerVeS {unrestricted reserve5 less flxed assets) of £2,501,975. This IS the equivalent of approximately 15.8 months operating and charitable expenditures. The trustees are committed to strengthening existing income streams whilst diversifying fundralslng activities to reduce reliance on single sources. It is accepted that thi5 will take investment In activities where the accuracy of predicting response rates, in terms of volLtme or value of gift, wlll be more challen8ing in the first Instance. Current reserve5, whllst Sn exce55 of those anticipated, will enable u5 to Davigate these more challengin8 times whilst diversifying income generation and developing the charity's objectlve activities, for future sustainabilitv. Golng concern The trustees consider that there are no material uncertainties about the charit15 ability to contlnue as a going concern. The trustee5 have made this a55e55ment for a period of at least one year from the date of the approval of these financial statements havin8 considered known tommitments, forecasts and projectlons and possible pressures on income 8eneration. After making these tonsiderations. the trustees conclude that there is reasonable expertation that the charitsble company has adequate resources to continue in operational e¥istence for the foreseeable future. The charitable company therefore continues to adopt the going concern basis in preparing the financial statements. 18 TRUSTEES ANNUAL REPORT FYE2022

DFabete5 Re5earth IknSFwn¢4ifon Our focus in 2022 and beyond The pandemic showed us the need to be agile, integrated, and adaptive in our approach. The past couple of years have been incredibly challenging and wwth the ongoing cost of INing crisis we need, more than ever, to be resourceful and innovative in our approach. We are experiencing rising costs in all of our charitable and fundraising artivities due to inflation, at the sarne time our individual donors are reviewing their own outgoings and tightening their belts,. and corporate partnership and grant funding opportunities are in short supply and all the more competitive. Ironically, at this time of financial uncertainty for everyone, more people than ever are tuming to charities for theif SUPPOrt. As we approach our 25 annlver5ary in 2023, we are intenl On reversingthe negative impact that both the pandemlc and the current economic climate have had on our ability to diversify and develop our fundraising portfolio and deliver Wellness programmes that meet the needs of the diabetes community and the healthcare professlonals that look after them. Our focus 15 very much on ensvrin8 that we have the necessary funds to build a resillent and sustalnable organisation that can meet the ongoin& and ever-chan8in& needs of our beneficiaries. To do this effertlvely, we plan to- Restructure our sUPPOrter database to ensure that we are tsklng a personalised approach to stewardship of our benefitiaries and donors reco8nisln8 that there are increasin8 financial pressures on our supporters,. we anticipate that recruitment of new supporters wlll be more difficult. so retentlon and Bood stewardship of existing supporter5 is ever more important. Review our current Wellness Pro8ramme activlties to ensure that they meet need and dellver Impactful outcomes whilst maximising opportunity for DRWF to engage In partnerships that deliver revenue and benefit for all parties. Effect organisotional change wlthin the charfty to create cost-efficiencles and make for an organisation that can navlgate the ongoing challenges and is robust and fit for the future. 19 TRUSTEES ANNUAL REPORT FYE2022

DkbÈtQ5ffte5earch& Weu￿55 Foundarton Reference and Administrative Details Charity Number.. 1070607 Company nurnber.. 03496304 Registered Office- Building IOCKJ Langstone Park Havant, Hampshire P09 ISA Tel.. [phone] Website- drwF.org.uk Trustees & Dir8rtors'. Mr W. Michael Gretschel Ichairmanl Mr john Alahouzos Mrs Valerie Hussey Mr Jeffrey Harab (retired April 20221 MT Steve Jones (elected October 20191 Dr Shivani Misra (elected January 20201 Mr Christian Gretschel (elected May 20221 Chief Eyecutlve: Mrs Sarah Tutton (Bonel Advlsers Banker5: Barclays Bank PIC I Churchill Place London E14 SHP Solititors: 81ake Morgan LLP New King5 Court Tollgate Chandlers Ford Eastleigh 5053 3LG Secretary.. Blake Morgan Company Secrerary Servlces Auditors: 6, Floor, 9 Appold Street LONDON EC2A 2AP 20 TRUSTEES ANNUAL REPORT FYE2022

DiaberesResearth et YIel￿essf￿fi￿tyc Structure, Governance & Management Governlng Document - The Dlabetes Research and Wellness Foundation, also known as DRWF, is a registered charitable company (Registered Charity No. 1070607 and Company No 034963041 limited by guarantee and governed by its Memorandum and Articles of Assoclation dated 15 January 1998 and amended by special resolutions passed on isth June 1998. 2 December IC￿1 and 24 April 2(KJ5. Recruitment & Appolntment of Trustees - The charity trustees are also the directors of the company for the purposes of company law. As dlttated by the charity's Articles of Association, dirertor5 are appointed by the Company Members. Any person desiring to be admitted to the membership of the company is required to apply in writing. No person shall be admitted until approved by resolution passed in accordance with the Articles of Association by the existln8 members, who hold absolute discretion as to the admission of any person. The Trustees of the charSty, being mindful that the board should offer a diversity of skills to fulfil statutory and fiduciary duties, are open to recommendations for new board members. The buslness and medicallhealth related 5ki115 Withln the existing board member pool are sUPPOrted by personal experience of diabetes, which a5515ts the board in ensurln8 that objertive activrties meet beneficiary need. Additionally, the board is sUPPOrted in its declslon-making processes by a Research Advlsory Board, whlch has an Sndependent Chairman. The RA8 members Teview applications and make recommendation for research fundlng awards. An Editorial Advisory Board provides support to the provision of health and social care information. 80th boards are made up of clinicians, scientists and other 'experts' in the field of diabetes and related health and strengthen the 5ervlces that the charlty offers rts beneflciaries. All board member5 are svbject to 'conflict of interesy pollcies and processes. Trustet Inductlon and Tralnlng - Newly elected Trustees receive an Induction Pack that outllnes the role and responsibilities of the Trustee, along with a history of the strurture and purpose of the charity. The pack includes a copy of the governing document and contact details of all board members. There is also an outline of the Chairman of the Board's role and ￿spOnSibl11t1eS along Wlth details of the executive officer taking responsibility for the daily management of the charity. Trustees are required to comply with the eligibility requirements Set out by Charlty Commission and to review and update an annual Re8lSter of Interests. Trustees are kept up to date with various govemance publications and notices from appropriate professional advlsory Memberships. Adéltion311y, trustees mi8ht be advised of appropriate govèrnance courses that they mav benefit from attending to enSLJre diversity and continuity of knowledge and ski115 Wlthin the Board. Newly eletted trustees are invited to attend a Review Meeting with the chair, after an agreed time lapse, in order to feedback their first impressions and address any concerns. Trustee5 are actively encouraged to partitipate In the charitvs outreach programme of educational events. Organlsatlon - The strategic direction and policy of the charity is the responsibility of the Board of Trustee5. During 2022 six trustees served on the Board, from a vèriety of profe55ional backgrounds relevant to the work of the charlty. The Board meets routinely throughout the year post-quarter end to review activities and management atcounts. Additional meetings are organised as required. Historically, the Board would meet at least once per year in person however this changed during the Covid-19 pandemic due to travel restrictions, with all meetings belng held virtually. This continued during 2022 and there were no meetings in-person during the year. The Chief Executive carries out the daily opÈrations of the charity and is responsible to the Board of Trustees. 21 TRUSTEES ANNUAL REPORT FYE2022

Di4￿￿5*ese￿rth w￿1￿55 FoundaUOD Connerted & Related pa￿eS - DRWF co-operates on several intellertual matters including sharing articles and reports with the OiabetÈs Research and Wellne55 Foundation Inc.. a 501C3 Not for Profit Company operating in the United States,. Association pour la recherche sur le diabete (A-rdl in France,. Insamlingsstiftelsen Diabetes Wellness Network Sverige Iswedenl,. Diabetes Wellnes5 Suomi (Finlandl and Diabetes Wellness Norge (Norwayl. These organisations are completely autonomous and independent with no legal connections. Mr. W. Michael Gretschel 15 the Chairman of the Board of Tnjstees of the Diabetes Research znd Wellness Foundation and is the volunteer President of the Diabetes Research and Wellness Foundation Inc IU5AI but does not serve on its boord of dirertor5. He is also a Board member of A-rd (Francel, DWNS15wedenl, DWS (Finlandl and DWN (Norwayl. Mr. John Alahouzos Is the Chairman of the Diabetes Research and Wellness Foundatlon Inc IUSAI and serves on the Board of Trustees of the Diabetes Research and Wellness Foundation. He also is a Board member of A-rd IFrancel, DWNS15wedenl. DWS (Finlandl and DWN (Norwavl. Mr5. Valerie Hussey sits on the Board of Trustees of Diabetes ftesearch & Wellness Foundation and Is also an 'alternate memberf on the Board of OWNS (Swedenl. The Chief Executlve of the Dlabetes Research & Wellness Foundation, Sarah Tutton, slts on the Board of DWN INorwayl. Link5 between these independent organisations, has proved Invaluable to the charity in helplng to strengthenlng It's international presence, for the purpose of supporting diabetes research programmes and 8lobal awareness activitles. A fiegister of Interests for Board Members and Key ManaBement Personnel Is malntained and revlewed on an annual basis. Remuneratlon Policy for senlor stsft - The Trustees, who are also the dlrectors, and the Chief Executlve Officer comprisethe key management peT50nnel of the charrty in charge of directlngand controllin& runnlng and operatlng the charity on 3 day-to-day basls. All trustees glve their time freely and no trustee recelved remuneration In the year. Detalls of trustees, expenses nd related party transa£tlons are disclosed in note 13 to the accounts. The salary of all staff, Including the chief executive officer, is reviewed annually and normally increased Sn accordance with avera8e earnings. In view of the nature of the charity, its size and structure, the trLJStees undertake benchmarking exercise, using online reseaich/tools, comparing the charivs salaries a83inst pay levels offered for SiTnilar roles withlr7 other ch3ritSes and companies. The benchmark is the mid-point of the range paid for these similar roles with consideration given to workload, level of responsibility. anticipated rate of inflation and other published research on third sector rate5 of pay. The charity conslders that its remuneration pollcy- Ensures delivery of the charltvs objettives Attracts and retain5 a motivated workforce with the skills and expertise necessary to ensure organi5ational effectivenes5. Is equitable and coherent across the organisatlon. Reflects the purposes, aim5 and values of the charitv. Ensures that pay I￿e15 and pay Increasesare appropriate in the context of the interests of our beneflciarie5. TRLISTEES ANNUAL REPORT FYE2022

D￿bere5 Resea￿ well￿55 Foundarion Rlsk Management- The Trustees have examined the major strategic, business, reputational and operational risks that the charity faces. This involves iéentifying specific risks,. assessing their likelihood of tstcurrence and potential impact,. determining what steps could be taken to mitigate those risks and delegating responsibility to key staff for overseeing management of the associated controls. The risk register is reviewed annually to ensure the adequacy of internal control mechanisms. Our approach to risk assessment and mana8ement is evidenced across the organisation and throuRhout our activities. The risk register was formally scored by all trustees in early December and resulting risks discussed at a Board meeting held on 22 December. The Board conslders that the major rlsks faclng the tharlty at present, are- Fundralslng and dependenry on single Income streams Competition Busine55 continuity The past few years have been incredibly challenging for all charities, with clear impact on fundraising activities and attrltlon In channels that, hlstorlcally, have been very solld in their return. The char5ty Is focused on d5verslfySng activities to reduce rcliance on unpredictable or single income streams with our Core Fundraising Group meeting monthly to fevlew and develop strateBy and operational plans to SUPPOrt thls. The fundralslng landscape Is hlghly competitlve at present, wlth more charltlesthan ever applyln8 for grant funding,. Inojlvldual donors reviewing their financial commltments because of the rlsing Cost of Ilvlng,. and legacy Income, whlch Is an entffirely unpredSctable Income source. contributlng a higher percentage than eveT of our overall Income. We are mlndful that fluctuatlons In Income could Impact on our ablllty to deliver dirert charitable activitie5, and so reMaSn agile in our approach to protect our aims and objectives. We are monitorlng income and expendSture very closely and endeavour to scale back expenditure in Ilne with income generatlon where possible. The trustee5 conslder that the Charlty hos robust internal procedures, systems and processes and believe that rlsk assessment Is embedded throughout the organlsatlon. 23 TRUSTEES ANNUAL REPORT FYE2022

Diab￿te$R*sQartfv it Wetknp$5FwJdation Trustees, responsibilltles in relation to the financial statements-The trustees, who are also director5 of Diabetes Aesearch and Wellness Founéation lor th& purposes of company law, are responsible for preparing the trustees, annual report and the financial statements in accordance ￿th applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice.) Company law requires trustee5 to prepare financial statements for each financial year that give a true and fair view of the State of the affairs of the charitable cornpany and of the outgoing resources and application of resources. including the income and expenditure. of the chèritable company for that period. In preparing these financial statements, the trustee5 are required fo.. selett sultable accounting policies and then apply them consistentlv. observe the methods and principles in the Charities SORP. make judgements and estimates that are reasonable and prudent. state whether applicable UK Accountlng Standards have been followed, 5ubjert to any material departures disclosed and explained in the financial statements. prepare the financial statements on the going concern basis unless it 15 inappropriate to presume that the charltable company wlll contlnue in business. The trustees are responsible for keeping proper accountlng records that disclose wlth reasonable accur3cy at any time the financial positlon of the charitable company and enable them to ensure that the financial statements omply wlth the Companies Att 2CK16. They are also responsible for safeguarding the assets of the charitable cornpany and hence for taking reasonable steps for the prevention and detection of fraud and other irregularlties. In so far a5 the trustees are aware: there Is no relevant audlt information of which the charitable company's auditor is unaware. and the trustees have taken all steps that they ought to have taken to make themselves aware Of any relevant audlt Information and to establish that the auditor is aware of that information. Audltors- Moore Kingston Smlth LLP have indicated thelr willingness to continue in offlce and are deemed to be reappoinled in accordance with section 487{21 of the Companles Att 2006. Small Company Exemptlon- Thls report has been prepared in accordance with the special provisions of Part 15 gf the Companies Act 2CK)6 relating to small companies. OnB If of the ust Michael Gretschel Chairynan Dated 24 TRUSTEES ANNUAL REPORT FYE2022

INDEPENDENT AUDrroR'S REPORT TO THE MEMBERS OF DIABETES RESEARCH & WELLNESS FOUNDATION Oplnlon We have audited the financial statements of Diabetes Research & Wellness Foundation I'lhe company'} for the year ended 31 Dec¢rnber 2022 which comprise the Statement of Financial Activities. the Summary IncorrE and Expenditure Account, the Balance Sheet. the Cash Flow Statement and notes to the financial stalemenis, including Signffj￿ant acwuntsng policies. The financial reporting framework that has been applied In their preparation is appluble law and United Kingdom Accounting Standards. including FRS 102 'The Financial Reporting Standard Appl￿ble in the UK and Republic of Ireland, {Uniled Kingdom Gener81ty Accepted Accounb"ng Pracbcel. In our opinion the finanaal stalements- give a true and fair view of the state of the Charitable company's affairs as al 31 December 2022 and of ils incoming resources and applicabon of resources. Including its income and expenditure, for the year then ended.. have been properly prepared In accordance wth United Kingdom Generally Accepted Accounting Practice., and have been prepared in accordance vthh the requirements of the Companies Act 2006. Ba818 for opinlon We conducted our audit in accordance with Intemalional Standards on Auditing IUKI IISAS IUKII and applicable law. Our re$pon5ibililies under those standards are further described in the Auditorf5 ResF)onsibililies for the audit of the financial s12tements sectt'on ol our report. We are independent of the Charitable company In accordance with the ethul requirements that are relevant to our audit of the financial 5ts1emenls in the UK including the FRC'S Ethical Stsndard. and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evKlence we have obtained Is sufficient and appropriate lo provid• a basis for our opinion. Conclu8lons relatlng to golng conc•rn Sn audiling the financ￿1 statements, we have concluded that the tnJ$tees' use of the going concern basis of accounting in the preparalion of th8 financial statements 1$ appropriate Based on the work we have performed. we have not rdentified any meterral uncertainties relatin9 to events or conditions that, individually or collectively, may G851 signihcanl doubl on the charitable ¢ompany's abilty to continue as a goin9 concern for a Feriod of al least twelve months from when the finaneAal slaternenls are authorised for issue. Our responsibilities and the Tesponslbilitie$ of the trustees with respect lo going con¢em are described in the relevant sections of this report. Other Inforniation The other inforrnation comprises the informats.on included in th& annual report, other than the financial Statements and our auditor's report thereon The trustees are respwsible for the other information coniained within the annual feport. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise expI￿ltIY Stated in our reporL we do not express any form of a$5urance conclusion Ihereon. Our responsibility is to read the other information and, in doing so, consider whether Ihe other infomialion is materially inconsistent with the financial statements, or our knowledge obtained in the course of the audit or otherwise appears lo be materialty misstated. If we idents'fy such material inconsistencies or apparent material rnisstalements. we are required to determine whether there is a material migslatement in the financial statements themselves. If, based on the work we have performed, we conclude that the￿ is a material misstatement of this other Infom￿"0￿, we are required lo report that fact 25

We have nothing to report in this regard. Opinions on other matters prescrlbed by the Companle8 Act 2006 In our opinion, based on the work undertaken in the ¢ourse of the audf('. the infomalion given in the IfUStees' annual report for the financial year for which the financial ststements are prepared is consistent with the financ￿1 statements,. and the trustees. annual report has been prepared in accordance wilh appllcable 18gal requirements. Mattern on which wo aro requlred to report by •xcepllon In Ihe light of the knowledge and understanding of the company and its environment obtained in thè ourse of the audit, we have not idenlffied material misstatements In the trustees, annual report. We have nothing to report in respect of the following matters where the Gomp8nie$ Acl 20(￿ requires us to report lo you if, in our Opin￿n.. adequate accounting records have not be8n kept, or relums adequate for our audit have not been réeèived from branches nol visited by us," or the financial statements are not in agreement with the accountin9 records and relurns.. or certain disclosures of trustees, remuneration specthed by law are not made.. lorl we have not received all the information and expkqnations we require for our audit. l orl the Iruslees were not enlilled lo prepare Ihe financial statements in accordance with the small companies, regime and take advantage of the small companiès exemption in prepafing the trustees, annual report and from prepanng a strategic r8porL R•spon81bllltle8 of tru8tee8 As explained mor8 fully in the Iru$lees' responsibilities Stslemenl sel out on page 24. the Iruslees (who are also the directors of the charitable company for the purpose5 of company lawl are responsible lor the preparation of the finanaal stslemenls and for being satisfied that they give a true and fair view, and for such intemal control as the Ifustees determine is necessary to enable the preparation offinanci81 statements that are free from mater￿1 misstalemenl, whether due lo fraud or error. In preparing the financial statements, the trustees are responsible for assessing the charitable company's ability lo continue as a going concern. disclosing, as applicable, matters related lo going concem and using the going concem basis of accounting unless the trustees either intend lo liquidate the charitable company or to cease opefations. or have no realistic allernalive bul to do so. Auditor's Re8ponslbllltle8 for the audlt of the flnan¢lal statgments Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due lo fraud or errnr. and to issuè an auditor's report that includes our opinion. Reasonable assurance is a h￿h level of assurance bul is not a guarantee that an audit conducted in accordance with ISAS IUKI will a￿VaYS detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material rf, individually or in aggregate, they could reasonably be expected to inlluence the economic decisions of users taken on the basi$ of these financial statements. As part of an audrt in accordance with ISAS IUK) we exercise professK)nal judgement and maintain pr¢)fessi0ft81 sGeptirisrn throughout the audit We a￿ also: Identify and assess the risks of material misstatement of the financial statements, whether due to fraud or error, design and perform audrt PTYJ(xdures responsive lo those risks, and obtain audil evidence that is sufficient and appropriale lo provide a basis for our opinion. The risk of not detecting a material misstate￿nI resu￿"ng from fraud is higher than for one resulting from 26

error. as fraud may invofve collusion, forgery. intentional omissKsn$, misrepresentations, or the oVerr￿e of intetnal control. Obtain an understanding of intemal control relevant to the audit in order lo design audit procedures that are appropriate in thè circumstances, but not for the purposes of expressing an opinion or¢ the effectiveness of the charilable company's intemal control. Evaluate the appropnateness of accounting poliues used and the reasonablèness of accountsng estimates and related dk%closures made by the trustees. Conclude on the appropriateness of the Irusiees, use of the going concem basis of accounting and. based on the audit evidence obtsined. whether a material uncertainty exists related to events or condibons that may cast significant doubl on the charitable company's ability to continue as a going Goncern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditorfs report lo the relaled disclosures in Ihe financial statements or, if such disclosures a￿ inadequate, to modify our opinton. Our conclusions are based on the audit evldence obtained up to the date of our auditorfs report. However, future events or conditions may cause the ¢haritsble ￿MpanY to cease lo continue as a going concem. Evaluate the overall presentation. slwcture and content of the financial statements, including the disclosures, and whether the financkil stalements representthe underlying transactions and events in a manner that achieves fair presentation. communicate with those charged with governance regarding, ar￿ng other mattèrs, the planned scope and liming of the audil and signifunt audit findings. including any significant deficiencies in internal control that we identify during Our audit. Explanatlon a• to what extsnt the audlt w•$ consldered capable of drtectlng Irrègul•rltle8, In¢ludlng fraud Irregularilie¥, including Iraud. are instances of non-compliance with laws and regulations. We design prO￿dureS in line with our responsibilities, ouwined above, to delect material misslalemenls in respect of irregularities. including fraud. The extent to whKh our procedur8s are capable of delectsng irregularities, including fraud is detailed below The objectives of our audlt in respect of fraud. are to identify and assess the risks of material mis51alement of the financial statements due to fraud.. to obtain suffrcient appropriate audit evidence regarding the assessed risks of material misslatemenl due to fraud, Ihrou9h designing and implernenling appropriate responses lo those assessed risks,. and to respond appropriately lo instances of fraud or suspected fraud identified during the audit. However. the primary responsibility for the p￿VentiOn and detection of fraud rests with both managemenl and those charged with govemance of the charitablé company. Our approach was as follows.. We obtainÈd an understanding of the *al and regulatory requirements applicable to the charitable company and considered that the most significant are the Companies Act 2006, the Charities Act 2011, the Charty IFRS102} SORP, and UK financial reportlng standards as Issued by the Financial Reporting Council obtained an understanding of how the ¢haTftable company complies with these requirements by discussions with managernenl and those charged with governance. We assessed the risk of matertal misstatement of the financial statements, including the risk of material misstslement due to fraLtd and how it might occur, by holding discussions with management and those charged with governance. We Inqui￿ of management and those charged with governance as to any known instances of non-complian￿ or suspected non-compliance wrth laws and regulations. 27

Based on this understanding. we designed $pecffic appropriate audit procedures to ident instances of non-compliance wilh laws and regulations. This Included making enquiries of management and those charged with govemance and obtaining additional corroborative evidence as required. There are Inherent limitalions in Ihe audrt procedures described above. We are less likely to become aware of instances of non-complian￿ wilh laws and regulations that are not closety ￿lated to events and transactions reflected in the finan￿al statements. Also. the risk of not delecling a material Misslaten￿￿t due to fraud is higher than the risk of not detecting one resulling from error, as fmud may involve deliberate COn￿alment by. for exampfe. forgery or intenkn.onal misrepresentations. or through collusion. Use of our report This report ts made solely to the chafitable Company's members. as a body. in accordance with Chapter 3 of Part 16 of the Companies Act 20(*. Our aLsdtt work has been undertaken so that we might stale to the company's members those matters we are required to state to them In an audilof s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to any party other than the Charitable company and charitabk company's members as a body, for our audit work, for this report or for the opinions we have formed. J.A LL Dete.. 8 June 2023 Nell Flnlay8on (Senlor Statutory Audftof) for and on behalf of Moore Kingston Smrth LLP, Statutory Auditor 6th Floor 9 Appold Street London EC2A 2AP 28

Diabetes R88ear¢h arKI bVellF￿5 Foundatlon Stst•m8ntof Financial ￿1]¥1119¥ Ilncorporating Ih Sun￿ary lrn¢om• and EXpendF￿r• Accounti Forth• year endgd 31 December 2022 2U22 TOTAL 2021 TOTAL Fur FI￿d Fund¥ kn¢0rn9 Oonaion&?nd L4w 1.5M.Z66 149.478 12. 2.7 1.701.315 12,457 1 713 772 51.9fr4 1.252 149.478 12.U65 2.704 1.7S3,29 12.457 1.530.7T41 119.884 ?S.2JS 1,546.UgD 119.664 15.219 250 1.e81.193 4.868 1656.Q61 (Xh81 comofrom Chartla￿e ALvth Otblr IrKom4 Tor4iincom 1.964 1.565.907 1S2 51.934 1 670.775 Exp•nditur•OTr'. Rqwng Fund charit￿￿? Cther J11.127 1.589.295 1.$72.SS4 e6.901 1.639.415 1,589.295 1863.4 IIBiiAeUn• 249 718 14877 22Y Tr•n¥fvr Fu N•t Movthrrt In 15 To￿4 FuTrdi bmuqhtknw 2,751,6#3 2.775238 2.881.340 8,256 Totil lund* ¢arthd •)Th￿rd•1 31 DK•mbw 1022 751

Dlabetes Research and Wellness Foundation Balance Sheet As at 31 December 2022 2022 2022 2021 2021 Flxèd Ass•ts Tangible Assets 16 Current Ass•ts 5,841 6.535 Debtors Cash at bank and in harbd 17 1,205.599 1.703.863 541,825 2.708,728 2.909,462 3.250,553 Cr•ditors . Amounts falllng due within on• yur {404.663 481,853) Net Currgnt Auèts 2,504.799 2,510,640 2,768,700 2 775 235 Total Net A$80ts Rè8èrves Restrfct•d Fund General Rèserve 8.665 2,501,975 23,542 2,751,693 277523 2 510640 These fIna￿la1 statem•nts have be?n prepared in accordance wth the provlJion$ apPI￿able to C4)mpani8s sublecl lo the small companies reglme within Part 15 of the companigs Act 2006 and with the Financial Reporting Standard FRS 102 SORP1offective January 20151 The financial Statements w¢re approved. and authorised for rjistribufion, by the Trustees on ... an¢J signed on thèir behalf by: Trustee ichagl Gretschol The ac¢)mpanying notes fom) an integral part of these financi81 statements C¢mpany numbgr", 03496304

Diabetw Research and Wellness Foundafjon Statsrnent of Cash Flows For the year ended 31 December 2022 2022 2021 ¢aBh used in Operaung Athili 11.fM)5.5461 1448,4111 Cash Flows from lv•¥flng AetMtt•• on Bank tpos1 FLxad Assets 2,704 2.023 250 4.016 13,7661 Cash Flo￿ from Fln•n¢lng A¢tMb•• Chany It) ¢a•h*nd ¢••b ¢gulvalBnts in thoy•ar 11.(M)4.8651 1452.1771 Caih and Gwh equivalents Iwou9hl 1•tJanuary 2.708.728 3.180.W5 C￿h JrKI ulh •qufv•l•nts It SI￿ D•¢•mbw 2022 2 708 728 31

Diabetes Research and Wellness Foundation Notes to the Financial Statements For the year ended 31 December 2022 1 Accountlng Poll￿3 The financkgj statem8nts have been prepared in 8Ctordart6 wth the Fina￿>al Reporting Standard applicable in tt)e UK and Republic of Ireland IFRS 1021. The Charitable Corrpany Is a putAi¢ tnefrt c£)mparry lor Ihe purposes of FRS 102 8nd therefore the Chanty also prepared its financk81 statem8nts in armdance wrth the Ststsmenl of Recommended Pra¢lice appI￿ab￿ lo charities preparing th&r acwjnts in acwdance wth the Finantial Reporting Stsndard applic8ble in the UK and Republic of I￿land (The FRS 102 Chanb"e8 SORPI, the Companies Ad 2C(6 and the Charits"es Act 2011. The trustèès have 88sessed whelher the use of the going concem basis 18 appropriate and have conswjered possib events or condiL'"ons that mHJht cast signil¢nt doubt on the amity ofthe tharity to conts.nue as a going cOn￿M. The trust••s have rnade this assessrnenr for 8 period ol at1&8st onè year from the date of approval of the Iinanaal statements. In partscular the trustees have considered the ¢h•nVs forecasts and wojections and have taken aetount of pressures on donations income. After making enquiries lh& trustèes have ￿ndl￿ded that there 1$ 8 fftasonabK8 expectsb'on that the chaiity has adequate resourcès to ecrtinue sn operatK)nal ￿>stenCe lor the fores•ea￿e future. The charity therefor¥ conb.nues to adopt the going concem basis in preparing rts financsal $ts1omonts. Th• financial statements are prepared in sterfing, whth is th? luncb.onal Curren￿ of the compary Monetary amounts in these finanaal statements are rounded lo Ihe nea￿1 pound. The finanual statements have been prepared ¢Tr the hi81orical cost convenllon, modifi8d to Include eethn ffinancial Instruments at fak value. The pnn¢lpal a￿Unting polia•s adopted are Set out below. Crltlcal aecountlng •#tlrnj￿ and area8 ofjuduomfrni In the view ol the trustee8 in gpplying Ihe accounb'ng Oki&s adopted. no judgements were required that have a sKJnific8nt trll¥ct on the arnounts rocognised in the fina￿￿al sts¢&rnents nor do any estirnates or a$$urnptions made cary a signific8nt n8k of rnaterial adju81rnont In nèxt financlal year. The principal accounting policKe8 of thet company a￿ Set ¢)Jt beknw In¢om• Income 16 included on an a¢cru81$ Oasis #Xcepl donaty'¢)ns under gift aid together thè as3OCiated income tax re¢overie6 a￿ credited os income when the donations are ￿￿ve￿. Membership Subscnptions aio appoTb'oned across the m•rnbership subscription period. Legacl Legacae3 are recognised following probate and once there is suffiGEnl evYence that receipt1$ probable Bnd th8 amount of tho l&ga¢y receivable can be measurèd reliably. Where entilement lo a a¢y exists bLrt ther8 ts uncartainty as to its recelpl Of thè awynt re￿1¥able. dotails 8r• disek)s•d as 8 contingent ass•t until the criteria fgr income recognition 8r8 rnet. Publlc Donatlon* and Glft¥Jn4lnd Incoming reSoUr￿S in the fonn of Gifts-in-Kind are induded in th¢ St8tement of Finanual Athvth"e8 only when assets 4on8ted to the charity are distributed. Gift$4n-￿nd are d(￿ationS ol crjmrnodity'es direcify usable in ¢harit8ble prograrnmgs, such as food. kAankets, books, agrujltural and medThl sUpty￿s. The Charty has an internat￿3]lY rèeogni5ed and accepted monitoring programme in plu to ensure that comm￿11￿"89 8rÈ approprialety valued at who10s81e or less. culturally appropriate for the designate¢ programme. and can be both properfy shipped aryj distributed gratss to ￿e desgnated bentsfi¢iaries. Glft Ald R•payment¥ Incorne from gift aid repayment cL41ms 18 only induded f¢x daiffls whith have been submitted for tsx periods ending on or before the year end and when receipt of this income is certain. 32

Diabetes Research and Wellness Foundation Notes to the Financial Statements {Continued) For the year ended 31 December 2022 1 Accountlng poll￿8• Icontlnuedl Expendlture Expenditure. ¥thfich 1$ charged on an 8(YnJals basis. is aljocated beknn.. o exp8ndtture incurred dire¢lly in the effort to r8ise voluntary contritsJtH)n8 {cosl of genernling fuTids}: expenditure incurrsd directty lo the fvffllm•nt olthe tharrtys obiethvg8 (charitable &xp8nditure),' Charitable expenditu￿ compri8e8 all the expenditure lncJjr￿ by tho charity in meeting rts charitsble objectives and Is further analyse(I be￿een.. grants payable in the furtherance of th& chBriVs objectives o costs of 8clwities in lurthor8r￿e of th8 chativs objectNe8 0 6UPPOrt costs of the charity Cost Apportlonment Where items of expenditure involve more than one cost catègory these costs have been apportioned on a rèasonablg b8sis as determined by Ihe trustees. One particular area wharè the cost is material lo the charity 1$ In the production and distribulion ol direct mailings. On8 of the purposes of the mail shot is lo dev8lop a datab86e of of people ￿th 8 parbculw Inler¢&l in th8 a¢tivitie3 of the charity and Ils ch8rii8ble obJ'8ets. 11 1$ hold that iThJiwduals who make a £10 c)r greater donation. In response to the m811in9. have a degfee ol intefO$1 in diabet8s. They are int8rested because they suffer from diabetes, know sornebody who does or ¢kyJkl themselves be at risk of developing the conditlon. These ar¥ pr0Ci8ely the people whom the charity is trying to help 8nd cKJn$equenlly they recAvo thè benefits of the educational malerfal provlded by the charity. These high interest individuals Constitu￿ 239￿ of thè toi81 response8', so the charity allocates 25% ol the ¢051 of the mailing to Costs in fvrtheranc• of thé d)aritls objects. Furthemiore the remalning expenditure has beon allo¢alèd on the basis of whether the educational ¢onlenl of th8 Ind￿¥1￿￿01 malling is ￿n￿lCa￿tlY high enough so as to be m8teri81 When th18 hol¢J$ true the remalning cost ol the mailing is allocated on a provrata basis comparing the educational conlenl (costs in lurtherance of the charity's objecl$l lo the lund raising content {cosls ol generating fund5). The educational content is ¢Jelernined by the arrount of text and spa¢e ￿ each mailin9 th81 is dedicated lo mgterial of an educational natu￿. Telemarketing expenditure is allocated in a consistenl manner mailings, as described gt)ove, hènce the charity allocates 250/0 of the wsl of the telemark￿1￿9 calls ID Costs in furtherance of the caritys objectives, with the remalning expenditure allocated on the basis of whether the time spent during the l&lephone call is in 8<Lordance with the charily's objects or Olh8rwse. Fund raising expenditure i.e. Text that may induc• a donalion from the reapient, 1$ allocated upon the ba815 of the volume of Ihts text and space that is not related to text of an educational nature. SupFrtrt costs compris& all olher o¥erhead costs the running of Ihe charity a5 an organisation. Fund Accounting Designated funds are unres￿1cted funds eamrked by the Trustee8 for par￿UjIar purFX)ses. The aim and use of eath fund is set oth in the note8 lo the financial slalwnents. Unrestricted funds are donations and other inwning resour￿ r•cèiv8d or ger￿ated fc)r oxpenditure on Ihg gener31 objectives of Ihe charty. Restrictéd funds are donations r￿eNed from a donor who has speufied a part￿lar area of the chariV$ work lo which the donat¢on should be allocated. 33

Dlabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2022 Accounting Polic198 Icontlnuedl Grant5 Payabl8 Grants are recognisd when they become due for payment Induded wthin the Stment of Financial Activrtie8 18 the cost of grant in5ts1ments that are payable to Charitab￿ organisatk)ns l indivKluals in accordance with the charity's governing Instruments. together wth any grants payable for thè yèar. but not paTrd by the year end date. The value Df grants awarded which are subject to the tompletson of a fLrtJTe years performance is disclosed as g Finsnclal Commitment in Note 18. Tangible Flxed Agsets and Depr•ciation Depreciation is calculated lo write down the cost less estimated resldual value of all tangible fixed assets hèld for charity use by equal annual in5ts1menls over their expecled useful economic lives. Th6 rates generally ap ￿l¢able aff.. Office equipment, fixtures and fittin S-7 yeats straight lin¢ All tsngible fixed asselg C08ting more than £250 are caprtalised at their cost to the charity. Foreign Currenci8s Transactions in foreign Currencies are translated 3t the exchange rate njling at the dale of the Iransact6on. Monetary assets and 11a￿"1111e5 in foreign eurrenrAes are translated al the rale$ of exchange ruling at the balance sheet date. All exchange dlfferences ao deatt wilh through the statement of finarrial xtlvikn'es. Leallng CommItm￿ts Rentals payable under operatin9 leases are charged 8g4in$l income on a $iraight line basi$ over the kase term. Other Flnanclal In8trum•nts l. Ca¥h and ca#h equlvalènts Cash and cash equivalents indude cash at banks and in har#J and sf¢ort lem d8posils with a naturity dale of three monlhs or less. 11. O•btorn and Cr•dltorn Debtors and cr8dilors receivabte or payable vlthin one year of the reports.ng dale are carried at their al transaction pnce. Oebtorg and creditois that are reeeivable or payable in more than one year and not $ubje¢l lo a market rate of interest are measured al the present value of expected futu￿ receipts or paymenl discounted at a market rale of intsresl. 34

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Continued} For the year ended 31 December 2022 Donatlon8 and Legacl88 2022 2021 Donations Lottory Programme Legxs Received 759.181 .518 820.553 1,588.252 654,919 8,605 882,536 1,546,060 Includad in th8 above are r981rthd donat￿5 of £51.984 {2Wd2.. £152￿> Chorltsble Actlvltle8 2022 2021 Grants Receivgd Gfft Aid Receipts 48,231 101,247 149,476 20,548 99.11e 119,884 4 OUr Chadtabl• Tr•(Iln9 Actlvlti 2022 2021 Membership Subscriptsons Event Fee8 and Sponeorshp 9,336 3,529 12.865 10.223 4,998 15,219 8 Oth•r Incom• 2022 2021 Miscellaneou8 Incomo 12,457 12.457 4,866 Fund Rallny Cots 2022 2021 Caglng CArrq•rs Computer Charge8 Lettershop and Dat8 Postage and Shippinq Prints"ng Publlclty Marttstlng Costs Community FundraBin9 Mail Path Pryrnbrn$ Lottery Costs staff Costs (see Note 121 Sw88P8take Winners 185,Ice 139.103 5,811 6,353 42,000 6,153 1,533 2,025 1e,259 31.949 3.847 72.089 14.725 390 936 5,489 10.183 7,998 2,288 100 7,439 15,491 70,353 13.411 311 127 Ch•rlt•bl• Actlvltl•• 2022 Dlrn Expendrturn (Note 101 2022 Gofts In KITh {Not• g 2022 Support Costs INoi8111 2022 Total Gnnls Award (Not• 8) Rg5garch inttl the Rel*lof Dobetes Raising PutJi¢ Awaren88s of D￿bet85 27S,857 402.394 678.251 961,164 1,639,415 961.164 1,164 275.857 2021 Direct Éxpenditur• 2021 Grants Awards (Not• 81 2021 Glfts In nd INot¢ 91 2021 Support Costs INol8111 2021 Totsi INokn 101 Research into the Relief of ri'abetes Raising PublK Awareness of Diabeles 372.17T 397.316 769,493 819,802 1,589,295 819,802 819.802 372.177 397.316 35

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Contlnued) For the year ended 31 December 2022 8 Grant Awards 2022 2021 University of Oxford Univet8ty of Exeter Ipfeviousty Kings's College Lond￿l- Non ClinK31 Fejbwship 2018 ardiff universty- Non Clinical Fdlowship 2021 AgsoryatHJn pour la Retherche sur L8 Diabète Univer8ity of Exeter- 2021 Pump Priming Award Univ8rsIty of Exeter. 2021 Pump Priming Award Universlty of Oxford - 2021 Pump Prirning Award Universty C>f Roehampton- 2021 Pump Priming Award Nottingham Trént Univerwty- 2021 Pump Priming Award Newcastle Unlversty- 2021 Pump Priming Award Unlversity ol East Anglia- Clin￿1 Fell¢￿¥ship 2021 UniverB>ty Coll8g8 London- Non Clinical Fellowship 2022 133,024 122.386 64,978 64,978 900 59,563 200 19,989 20,000 19,985 20.wo 19,760 19,962 72.418 10,722 275,927 372,938 Lgss.. Undairred grants written bac* 170) (7611 275 857 372 177 36

Diabetes Research and Wellness Foundation Notes to the Financial Statsments (Continued) For the year ended 31 December 2022 9 Gift$4n-Kind The lollDwng donations made during the year wer& dam8d as Gift54n-Kind and are valyed in accordance wth current market ¢onditions prevailing when the gif( was rnade. Number of Shipments Gffts4n. Klnd valu• Shlpplng Costs 2022 Totsl 2021 Total 10 Dir•ct C17aritabl• Exyndttur• 2022 2021 staff C08ts Isee Note 121 Postagè Printing Public Mail Pack Premlums Educational Events carr￿r$ Grant Costs Lettershop and Dats 3￿,787 37e.118 203,382 763.383 66,803 87,670 11,726 1S.183 194,318 119,918 49,752 18,141 12,884 8,241 2,083 819 21,649 28.129 819 961164 ￿02 2022 2021 11 sUpportC￿ts Other Stsff Costs Profession81 Costs Management Ch8rgo Officg Expenses E8lablishmenl E¥4)en8es Bank Charges and Intgresl Pald FOre￿n Exchange (Lossl Depw8lion Irre¢oveiable VAT Amounts p81d lo Auditors Company Secxetarial Fees Oth8r Ovafh8ad Costs 2,051 29,885 141.610 84,748 43,881 3,444 3,998 2,281 65,877 15,022 350 4,189 397 316 16,755 159,771 66,995 47,123 3,984 5,265 2,717 72,333 22,284 350 2,769 402 394 Support Costs ara alloc418d to the Clwritable ewdrture olthe tharity in propOr￿On to the direct ¢y)$l oftl* actwity 12 W8g•J and Salarf 2022 2021 Wages and S818ries Social Security C¢)sts Pènsion Costs 419,928 35,139 13,789 468 e56 404,266 31,241 12,864 448,471 The key rnanagement personnel ollhe ¢hanty are lh& Trustees and the CEO. The total amount paid for kgy management p¢rsonnol Vfds £72,12412021'. £70,339). 2022 2021 No. No. The number of higher paid employees w8s in the barnl.. £60,000- £70,OCx) Pènsion contritryjtions payab￿ for the above indMdu81 wag £2.77612021'. £2.7221. The ave￿ge number of fUl￿tiMe ffjuivalenl ernployees during Ihe year wa5 12.912021 12.51. 37

Diabetes Research and Wellne$$ Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2022 13 P4ym•rtt to TYu8te88 No trustee or person vllh a larnityorbJ8kn8s5 a frIMlee. remun8rabon year, dkectty or ￿d￿8¢1￿. IrL¥r tharity. TTwslee ExE¢￿e5 Travd Maellrvj Costs £nA12021.. thli ofwthith £na12021'. £nt) waB rdmbuTred lo nl 12021.. rii) Trusts85. 14 8utylu$ ol lftcorn• ov4r Exp•ndltiii8 2022 2021 The $uWu8 ofirKcffjw ststeo aftwtharory.. Audrttys, RemuneraliDn'. . F8e relalry to fv Fknanraal Yéar - In respecl tsf non aLbJrt se Op&rnllrq Le88e r8rrta . Rgnt & Machknery - Other A$6ets 21.090 1,140 15,JOO 1.965 1.824 24,0 5,265 3.081 28.￿0 Forelgn Exch4nge Lo53 Deprècollon 3,999 13 Txatlon The comp•ny, 8 regh¢ered {•. l& not119￿ Ic¢efMwation tax in oftts opwalknl forthe ye•r. 18 T•ntylb￿ FL¥•d A•Mts forchartty U80 Offlc• •qulprnen( Ilxturtt and IIttID Coat AI 1 JBnuary 2W22 drtions ￿ Year Di$pgs818 In Year At 31 Detxmber 2022 36.004 2,023 37.027 D•prrtillo At 1 January 2022 ProTrA¢Jed in tho year ElinlnatoLJ Dn Dkpos81 At 31 rJe￿mber 2022 28,469 2,717 31,168 Plgt Book Valu• Al 310ecemter 2022 At 31 Decemb8r2021 17 Oobtorn 2D22 2021 Trade Debltys other Debto PrEpaymeni8 ano Atfxued Ino)me 1,920 19.144 1.184.535 1205 599 6.OOD 25,013 510.812 Ai Lkbtots ÈxeÈN ￿p3￿r￿niS are fffwxyal knthwments arKI rneowKed al8ettkTnenl ¥a￿È 38

Diabet•s Research and Wellness Foundatyon Notes to the Financial Ststements IContinu¢d) For th? year ended 31 DeeÈmbÈr 2022 48 Cr•dft4rJ'. ArnDUnhf4lllngdu•¥Aifth¢Jnw b•r 22 2021 Crgditus 124.587 210.955 54.952 14.2 71,ts) 81,650 Tax4nd Sod Seuyty Recon¢￿￿￿tr￿n OIGrTrts P&y4t4p'. at 1 J&nwy2022 Gr4ffl1$ tylhe YeAr Ir#XNQ61 ranks P Year )J.741 275,857 401.138 372.177 241 182 S16 238 19 DDt•rr•d Incom• 2022 IrK0￿￿ l￿tJ￿llry2022 Rgieg8eato In¢om• DofeTh6 kn Yeqr Dofrna Ir￿m•￿ ts1￿ Oec•mberX¢2 14.0401 . Evoni ReO8tr4110n F•fjs . R•siriCt•a R•¢qiwU > 20 RM•r¥•• hl¢W• ITr Y•&r E¥wndiwr• hl Ymr l J•Dw G•rt•vAI Mo¥•m•rtin Ymr al 1)vmty•r 2022 Ymr .319 113,3191 123,0421 Rqsiildthl rewnq Ch￿lm￿ crAw•b B,e69 15001 11g),ODDI 014￿ndol￿Ih Fur 11>).￿0) 2.&)1.093 i.g63 4P) 2.501.975 Ir￿m￿1n Yur E¥p•ndlturn In Y••r M￿l￿rTrt Y••r 31 O•c•rnb•r Y•v RMlrJct•d Fthid rdlng R•$tsitstd GJ¥ R•sTrtthd FLnd D4 •258 14.7èe 25.042 IJ0,￿ Ggrral Regerve 29.817 £8.fjQ912021 £14,78¢1 Fwd TOMI Tw¥JlbknAsEqL A$14ti Civr•M LI*1￿5 5.841 2.WO.Tr97 S,841 2.W.462 39

OiabÈt¢s Research and Wellness Foundation Notgs to the Financial Statement5 (Continued) For the year ended 31 De¢ember 2022 21 PaymDts to Connucted Ch•rfU¢s Naturn of 2021 conw¢￿ Charlty th¢y In thp)wr iqbetssResearch Wnes1 Foundariw Irt. 159.771 141.810 in ¥Jtr $h8nng ol $t¥ff. Th6graTrl ¥rd8 m•Ye 10888lStvAlh the mLln} oflho A88c¢￿￿n,%a￿￿ •rFd +JU￿￿onal Pfogramows. AS￿41￿0 Pru L• ReC￿rthe SUT La Liabete Nitur•olRelabonJhlp 1 Dl8tsles Rese8ich and Dyn[• S•Fw4 Trj butmr. John ALghtyJ&x% iiton tho Board c rrusto88 ol lIK4s5o￿$￿0 ch811ty in the Unw Stste 2 As￿latiOn Pour La ReC￿rthe Sw La Thtbete ￿0￿[￿￿•1eparate ard OY•￿￿, ￿ MrW.M. lknhel. A￿hl¥JI0￿ ants J. H3r){rttWed 241h Wl 20221 ￿t¢￿i thè Boatd in Fr•K•. Furtthtdetsls reooTdlw th• rW￿¥hIp￿ b6froj￿l In RWL 22 Fln•n¢lai Comm#rnMI• ThtrLaity f17•r￿1 Gornmdrnen￿ ¢fU21.775 (2011" £575,584)farwty L¥rt tr)rlh•￿T endgd Jl ￿m￿2022. • théy ￿bI•¢t io the fetypenl fvIThMir¢eertn Thè•YKwts puyw•8•fthw 2422 2021 P4y•trA• 1022 Pay1￿￿ h 202Y Paya￿9 kn 20 ptya￿ hi 2025 24B.667 221.$95 105.222 381,522 218.006 22,247 821.n5 57S 8H4 23 ope￿￿9 L•ueB Al 3181 t)8cemtéf 2022, kn¥¢￿rttyhI8 r•JThl￿w41￿d•rc4MrqI•$8ots ats fdhx•' 20 2Q 2021 2021 w.thkn (w to Fh Ye Within Year Twots Flvg Ye8 L8nd Ind 8US￿l￿g9 otn•i As￿3 28.( 2.918 21.e33 3.946 49.633 4.$98 TMeh¢rftr¥offlc• 18•8ocOmrnen￿ (x)￿ 20181th a wnt4•t<yeor$81 • wdt28.CIJO.2S o•. with h¥0 th1c0￿1￿¢ OF 10 •sL. 4uDng rtQUL¥J ty 50%. Althe lindlord's requ8Sllhe Laity rMYll¢ ¥ L¥11￿1 oflth Mmp thabtsl On SlltJ•nuary 2023v a rle•se a ¢8coJnted fftJLY3 1ffl19rtsth1. 24 ol Not MDVOin•Thtbn F¥rKts to N•1 FltyAtlrom C¥w¥OJwJ Pu¥id 2021 Nel ￿rnent In Fwd¥- Swp1￿j(DItt Add b3ck Oew8ciI(M Chaffj• DeJJ¢t IniEi&81 Inc￿ InV¥Mg Athtt Dociease Iincisel In Detyttys {DerT8asel In c￿dit N4t Ca8h u8ed ￿ 0￿rab"ry Activi [284,5951 2.717 12,7041 (683,7741 7.19ll 1214,3671 2.281 12501 1402.3801 166.279 448411 25 M•rnborn' Lthblltty The Fowd9tm is 8 c¢mkwyRfvJ by￿￿An￿o. morrs ISI12021. 51 È1. 40