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2021-12-31-accounts

Dlabetes Research and Wellness Foundation IA Company Limited by Guarant¢el Charily Number: 1070607 Company Number: 03496304 Financial Statements For the year ended 31-Dec-21

Diabetes Research and Wellness Foundation INDEX Page Report of the Trustees 1to25 Independent Auditors. Report 26to29 Statement of Financial Activities 30 Balance Sheet 31 Statement of Cash Flows 32 Notes to the Financial Statements 33to41

Diabetes Research Wellness Foundation Diabetes Research and Wellness Foundation {DRWF) IA Company Limited by Guarantee) REPORT & FINANCIAL STATEMENTS For the year ended 31 December 2021 Re8lStered Charity Number.. 1070607 Company Number.. 03496304 rl 2021- marking the centenary anniversary of the discovery of insulin Frederlck Banting and Charles Best, who successfully isolated the hormone insulin, one of the greatest medical breakthroughs in the treatment of diabetes. THANK YOUT To everyone who donated or undertook an activity to support Us, all over the UK, during the most diff icult of times. Your contribution has helped to safeguard our awareness, educational programmes and research funding activities. THANK YOU! for being part of a powerful community who are intent on investing in a brighter future for all people with diabetes #PartoffheNextBigBreakthrough

DiabetQSRe￿a1(h WÈUness F￿ndarIOn Message from our Co-Founder & Chairman- Michael Gretschel Following the challenges of 2020. we worked hard to maintain focus on returning to 'normal'. This was easier said than done of course, given the continuation of the Covid-19 crisis and the ebb and flow of lockdown restrictions which impacted our ability to run in-person and community engagement activities. Notwithstanding the continuing challenges of the pandemic. the year gave us the wonderful opportunity to celebrate the centenary anniversary of the discovery of insulin and focus on what is one of the greatest medical breakthroughs in the treatment of diabetes,. a treatment that transformed a fata disease into a manageable tondition and prolonger of lite. In celebration of #l(IOYearsofln5ulin, we ran a week-long programme of online activities which commenced on World Diabetes Day, 14, November. Professor Emeritus David Matthew5, Oxford University and past Chairman of the DRWF Research Advi50ry Board. hosted a panel of diabetes experts who explored the advances of diabetes research past and present. and discussed hopes for the future. The discovery remains one of the most important medical breakthroughs in history. To the present day, milllons of people still rely on Insulin. It ignited a century of development in diabetes care and treatment and ha5 undoubtably saved million5 of lives. At DRWF, we thlnk it is time for the next big breakthrough: our goal is to find a cure for diabetes. In pursuit of this. we fund some of the best and brightest diabetes researchers in the UK and around the world, whose work improves our understanding of diabetes- explores new treatments. develops self-mana8ement strategies,. and seeks out potential cure pathway5. Existing on voluntary income, the donations that we receive frorn our supporters are an investment in a brighter future for people with diabetes. We have learned much throughout the pandemic. We have all seen how worldwide collaboration in the research community can achieve great things at pace. The dedication and commitment of our diabetes research community is second to none. Now is the time for the next big breakthroughl I would like tothank everyone who hassupported ourwork inthe p05tyear. Whilstwe may have been more remote than we have ever been, our supporters and beneficiaries have been uppermost in our minds. Our hope for the future is clear. We are more focused than ever on our goal of a cure for diabetes. You have our word. Thank you. Mlke Gret5chel March 2022 TRUSTEES ANNUAL REPORT 2021

DlèbetesR￿vr(h Ér WeiinE55 Fovndation st Report of the trustees for the year ended 31 December 2021 The trustees are pleased to present their report and message from the Chairman together with audited financial statements for the year ended 31" December 2021. The financial statements comply with the Charities Act 2011,. the Companies Act 2006; the Memorandum and Articles of Association and are prepared in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland IFRS 102 Charities SORPI (effective from I" January 20151. Our purpose, aims and activities The objects of the charlty are: To asslst in the relief of persons with diabetes and any similar or related diseases or conditions To raise public awareness about diabetes and any similar or related diseases or Conditions, their incidence, causes, treatment, avoidance and relief The focus of our work There are more than 4 million people diagnosed with diabete5 in the UK. This figure has more than doubled in the last 20 year5 and it is anticipated that if nothing changes. this will rise to 5 million in the next 4 years. Around 90% of people with diabetes have type 2, which can often be prevented. There are a number of risk factor5 which in¢rea5e the likelihood of a type 2 diagnosis, such as being overweight or obese, which put5 people at greater risk of a range of chronic health conditions and ultimately increased risk of premature death. Approximately IO% of people with diabetes have type I diabetes which is a chronic autoimmune condition where the body 15 unable to produce insulin which is required to regulate blood sugar levels. Type I diabetes carsnot be prevented. It is estimated that up to 5% of those diagnosed with diabetes have rare types such as MODY (maturity onset diabetes in the youn81, CFRD (cystic fibrosis related diabetes), LADA Ilatent autoimmune diabetes in adults) and a small handful of other types. It is estimated that the care and treatment of diabetes costs the NHS around IO% of its annual spend, which equates to approximately £10 billion per year. This is a staggering £l.I million per hour. Whilst all diabetes can lead to significant health challenges, such as increased risk of cardiovascular disease, blindness and amputation, it is import3nt to remember that type 2 diabetes can be prevented, or onset delayed. There is also evidence of people with type 2 diabetes achieving 'remi55ion' where they have had major weight loss through restrictive diets or bariatric surgery. Self-management of diabetes is central to reducing the risks associated with complications and therefore much of our work is focused on providing information and educational support programmes that empower self- management and seek to encourage a pro-artive approach to good self-care. We consider that those with the greatest knowledge of their condition will have a better understanding of the disease and will be better equipped to have an impact on the progression of their diabetes and any associated complications. Our Diabetes Wellness activities in the commLJnity provide a great platform for meeting people sharing similar health concerns, making new frierbds and building peer support networks. all of which serve to enhance both the physical and psychosocial management of diabetes. TRUSTEES ANNUAL REPORT2021

DiabetE5 keseDrch WEilnESs FDundaThon The research we fund spans all types of diabetes and related health, helping improve understanding of cause, treatment and management with our goal being to find a cure for what is, considered to be, one of the 21" century'5 global health challenges. With the commitment of a multi-disciplinary Research Advisory Board, and a rigorous peer review process for applications, we invest in innovative proof of concept Pump Priming project5. Clinical and Non- Clinical Fellowships which we believe will demonstrate impact for people with diabetes in the fastest timeframe. To-date, we have committed almost £13 million to research since our first awards were made in 1999. Demonstrating public benefit The trustees confirm that they have referred to the general guidance set out by Charity Commission on publlc benefit. The trustees are satisfied that the Charitrfs activities meet the principles of public benefit, defined as providing an identifiable benefitls to the public, or section of the public. and know of no detriment or harm that may be caused as a result of these activities. which are clearly Set out throughout this report. Volunteers As a small team delivering numerous activltles. we rely on the support of volunteers who, participate by helping with administrative tasks in our off ice- delivering diabetes awareness and information materials; undertake user involvement exercises to help steer ènd develop our programme activities.. support our educational event5 and community fundraising programme or sit on one of our expert panels for research or information review. The number of volunteers fluctuates each year but Ss cruclal to helping us spread the word about the work we do and to SUPPOrt local and national community fundraising initiatives. We had hoped to grow our volunteer network through a higher level of community activity in 2021, however the pandemic prevented us from doing so. We hope to be able to resume community activity as soon as Covid-19 allows and plon to build on the number of volunteers who support the charity as soon as possible. In the meantime. we wholeheartedly thank all of our volunteers for their time, expertise and commitment to our work which helps us raise awareness to the charity, maximise income and maintaln hlgh standard5 of work. Measuring Impact We use a mixed methods approach to monitor and evaluate our activities in order to ensure that they remain true to purpose and achieve desired outcome5. Stakeholders and beneficiaries are involved in these evaluation proce55e5 to ensure the continued relevance, quality, accessibility and effectiveness of activities. We also ursdertake independent evaluation with specialist partners for specific projects where impartial opinion andlor additional expertise Is required. Beneficiary need is at the heart of our support programmes and research funding. Service users are involved in lay review of our Diabetes Wellness News and patient information literature helping us to meet our commitment to delivering relevant, clinically evidenced and accessible information. Additionally. beneficiaries are invited to participate in Focus Groups which ensures that service users steer our programme development, helping us to demonstrate the impact that our work has on day-to-day management of diabetes and quality of life. Activities & Achievements in 2021- #IOOYearsoflnsulin Our impact, through Awareness, information & support Our Direct Mail programme played a key part in Ouf communications strategy during 2021, enabling us to stay connected with key audiences who do not routinely engage with online channels. We distributed 400,114 campaign packs in 2021 an increase of around 55% on the previous year. The health information contained within each campaign is targeted at beneficiarie5 who could act on the information, either in a preventative way (type 2 diabetes) or to inforrn and sUPPOrt those living with diabetes lall types), in their self-management of the condition. Whilst maintaining relationships with existing supporters of our appeals, we also reached out to higher volumes of prospective beneficiaries and supporters of the charity during 2021. We had TRUSTEES ANNUAL REPORT 2021

DiabpiE5 R•s•ètth Wellness Foundaiion an average campaign response rate of 9.5% acr055 4 streams resulting in over 38,149 response5 from across the country. We know from experience that it is likely that many more opened and read the appeal but chose not to make direct contact with tjs at that time. Historically. we have seen numbers of people respond to communications that have been distributed many month5. or even year5, before as they have held onto the information provided for future reference. These campaign5 also act as a stewardship tool. helping us to stay connected with long- standing supporters of the charity. Health Unlocked Forum.. Our awarene55 messages are reaching wider audiences than ever before supported by our increased provision of news and articles on our website and social media channels and via our Health Unlocked community forum, the world's largest social network for health. The DR WF Diabetes HU forum has a total 60113ll-time members an increase of 6% on 2020. Around IO% of all members are very active in posting and joining discussions and average session time in the forum has increased by 14% to 4.5 minutes. The forum provides a 'safe space, for people with diabetes to share their experiences, gain support and make a difference to others too. We continued to focus a lot of time and attention to online engagement during the year. This was essential in ordei to maintain our connection with the wider dlabetes community when we couldn't engage through in-person artivity. We doubled our efforts to generate regular reliable news items, with additional online self.management resources, such as our podcast series and pre-recorded video content. Our website received a total of 416,916 page views from 366,312 unique vi51tors. This continues the upward trajectory of engagement seen in 2020 by 12% in overall traffic, with a small decline of 1.5% in unique vi55ts. In 2020 we saw a masslve three-fold increase in the volume of patient information resources downloaded from the webslte. Thi5 Wa5 a5 a result of our significant efforts to divert audiences to our site when covid-19 hit. This had reduced in 2021 to what we would consider to be more 'normal' levels wlth a total of 5124 pdf downloads,. 240 audio downloads in 3ddition to the 81cKJ hard copy resources that were ordered via telephonelemail. These resources, whilst still appropriate in content for people with diabetes are currently under review as part of our Wellness Action Group activity to reconsider 'what good looks like, for the diabetes community going forward. Whilst in 2020 we saw an increase in the number of visitors to our podcast Series 'Living wlth Diabete5' which resulted in 549 downloads, this had reducetl in line with the number of information resource downloads in general, in 2021. There were 380 downloads in total, a reduction of around 30% on the previous year. The podcast programme is a work in progress and another channel through which we can offer support through the sharing of lived experience. We look forward to developing this avenue of our work In the future. In 2021 we increased our efforts to raise awareness of our attivities and services to more people through social media campaigns with most engagement being seen through our Facebook page. Our sponsored content reached almost 1.7 million people with 5,431,690 impre55ion5. There are some fluctuation5 in our social activity at present, and it is very much a growing area of activity through a platform that enable5 US to engage in conversation with a diverse audience, often answering general diabetes related self-management queries, addressing confusion5 about diabetes, and increasingly responding to questions and comments about diabetes research and recent advances. There wa5 le55 reach in 2021 than in 2020 but we see this partly as a reflection of the knee-jerk reaction to high numbers of people turning to online methods of connection in 2020. Bv 2021 some of thi5 had dwindled as people were keen to get back to 'real life, engagement. We distributed 114.860 copies of our newsletter, Diabetes Wellness News, to subscribers, healthcare professionals and regular givers. This is a 2% decrease in the circulation numbers of 2020. Much of this reduction is related to deceased notifications received from subscribers in the year. The newsletter is distributed to annual subscribers and on a complimentary ba515 to healthcare providers who Share the information with their patient communities. On a quarterly basis the circulation is boosted as we focus on the research eSement of our work and send a copy to our regular giver5. It is difficult to accurately predict the true TRUSTEES ANNUAL REPORT 2021

DiatotEs Research t WellnÈSS FoundaiTon readership of the newsletter but through anecdotal evidence. it is much wider than those who have specificallv requested to receive it and is seen as a stewardship tool to maintain engagement W￿th a v3riety of different supporter and beneficiary audiences. Our Diabetes Awareness Necklace is distributed free of charge to people with diabetes and healthcare professionals for onward distribution. These necklaces provide emergency identification for those with diabetes should they be unable to alert the emergency services to their condition. They carry the wording '[ have diabetes. please test my blood before treating me, They are distributed along with medical check-up cards that are used to record tests and result5 to inform 5elf-management strategies. We responded to 1437 specific requests for free necklaces during the year. a small reduction of 1% on the previous year. Thi5 is not unexpected given that a large percentage of these resources are distributed at face-to-face events. IHAYE C41B Quality in Care Diabetes- award winning Diabetes Wellness educational events QIC YIIIINZR Diabetes structured education airns to provide people with diabetes with the knowledge and tonfidence to 5elf-monage a long-term condition effectively. The offer of structured education across the country has improved over more recent years. However, the rates of attendance are still very low and vary widely. Self-management is central to diabete5 care. Yet, it is reported that high numbers of people with diabetes experience emotional or psychological problems, such as depression, anxietv and diabetes distre55, all of which can impact the ability and motivation to self-manage effectively. This leads to poorer health outcomes, reduced quality of life and increased healthcare costs. Being able to access appropriate support 15 integral to good self-management. We have been running an annual programme of Dlabetes Wellness events since 2001. We work with diabetes, and related healthcare professionals to facilitate workshops thot provide relevant, up-to-date, evidence-based information covering all aspects of diabete5 and related health. Delegates choose the sessions and talks that they attend meaning that they create their own agenda for the day, improving engagement and supporting better outcomes. These events bring together a wealth of information, expertise and peer support under one roof. We know that managing diabetes Is challenging and effective coping strategies are crucial to support optimal health. These coping strategies are important not just to people living with diabetes but their family, friends and tarer5. Peer support plays an important part in emotional wellbeing and this in turn can have an obvious impact on the ability to self-manage effectively. For this rea50n. we feel it is important to include family, friends and carers In workshops and di5CL155ions which facilitates discussion around managing diabetes, perceptions and expectations, in an environment where everyone has experienced or is experiencing something similar. These events are relaxed and welcoming in approach. They are inclusive and provide for diverse needs. They also provide an amazing opportunity to spend time with a whole host of health care professionals askin8 the questions that really matter to the ir)dividual, in a relaxed and informal environment. The continuation of Covid-19 restrictions in the first half of the year meant that we were unable to run our in- person Diabetes Wellness Events. However, every effort was made to ensure that we were still able to connect with the wider diabetes community through offline and online artivities. To that end, we h05ted a number of digital events throughout the year to ensure that we remained in touch with beneficiaries and supporters of the charity. Diabetes Wellness Family 'Camp in the Cloud, There are around 29,000 children and young people in the UK living with Typel Diabetes. For these young people, quality of life can be adversely affected by isolation and their inability to participate in many of the everyday TRusfEES ANNUAL REPORT 2021

DSJb*ÈsRe5Èarih Wellne55 Foundation activities enjoyed by their friends and peers. This often results in a growing lack of self-esteem and confidence, which can become a barrier to future growth and development. Having provided a very 5ucce5sful residential Diabetes Wellness Family Camp in partnership with Over The Wall in 2019, we had planned to expand on this offering in 2020 and 2021. The pandemic had a significant impact on thi5 programme but the OTW team, working with digital consultants, devised a unique online platform to enable a virtual Comp in the Cloud ICITCI to take place. This online platform meant that we were able to present a wonderful opportunity for families with children with Typel diabetes to connect with others experiencing similar health issues, reducing the feeling of isolation during particularly isolating period. We reco8nise that the online experience and a550ciated benefits are somewhat different to an in-person event, but there is opportunity through this platform to reach those children who may not have been eligible to attend an in-person residential event. due to significant health challenges. This potentially widens our reach quite significantly and so we intend to explore the possibility of carrying out online and residential events of thi5 $0rt, going forward. Camp In the Cloud enabled us to engage with 68 families in 2021. just over 21JO participants in our actlvities, in total. Dr Mayank Patel. Consultant in Diabetes and Acute Medicine at Universlty Hospital Southampton NHS Foundation Trust and member of the DRWF Editorial Advisory Board, said: "I wa5 delighted to be approoched by the DR WF to support their virtual Diobete5 Wellne55 Family Camp. To spendsome time online, seeing and heoringfrom kid5 living with type I diabete5 and their parents. whilst watching them creote their own brilliont orrt7y of diobetes related comic choracter5 live was fontostlcl" "As CO-cre¢7tors of the Type l Orlglns comic series, Profrssor Portho Kor, Donny ot Revolve Comics and I, hove been ple05ed with how well this has been received by those living Wlth type I diobete5 ¢7nd those close to them, het71thcore profe55ionals ond members of the public." In the future, we hope to support famllles of chlldren wlth type I diabetes through a mix of virtual and residential events allowing children to experience the mischief and magic of camp, regardless of the constraints of their illness. Amy and Sophie along with their parents participated in Comp in the aoud. They thoroughly enjoyed the comic book workshop hosted by Dr Mayank Patel and Revolve Comic's, Jim Lavery. They were tasked with creating their own Type I diabetes cartoon character. There were a whole host of amazing characters designed by the children with one design selected to be transformed into a fabulous piece of cartoon artwork. Amv and Sophie are pictured here with their winning design of Pancreas Power and Evil Keto. VII KETO As well as the fun element of Camp, all families are invited to participate in a Q&A session hosted by diabetes and related healthcare professionals. In 2021, Dr Shivani Misra, Diabetes Consultant Physician from Imperial College, London and DRWF Trustee. and Hayley Faulds. diabetes P3ediatric/transition nurse from University Hospital, Southampton, supported these events sharing their wealth of expertise and experience, answering questions and facilitating discussion amongst the farnilies. The importance of feeling sUPPOrt with a diagnosis of Type I diabetes - TRUSTEES ANNUAL REPORT 2021

Diabete5 Re5eJrth tr WeUne55 Found8tiOn Sophie's story... -sophie w05 diogn05ed with type I diubete5 agedeight oround Christma5 time in 2020. We hod noticed she wosn't hersem on Christmos Eve.. she seemed tired ond not os excited a5 she should be before Christmos. This continuedfor o couple of doys t7nd on Boxing Doy evening she was Sick and become very poorly. After ringing 111 the dortor told us to coll for an 17mbulonce os he suspected she hod type I diobetes. When we got to hospitol her blood sugor was 36 and the ketones were too high to meosure. It wos rerrifying to see how poorly Sophie become so quickly. There wa5 u150 afeeling of tremendou5 guilt 05 to why we hod not Spotted thi5 sooner. The hospitul stoff17t Leeds Teochlng H05Plta15 were all umazing und we can't thonk them enoughfor the c¢7re we received. Sophie spent a night in ICU (intensive care unit) and then moved to the ward where we had o steep andfvst learning curve to comprehend how to corb count, monitorblood, give insulin ond more so we could monoge Sophie's type I diobetes ond be oble to go home. This learning was further complicated by Covid-19 05 only one parent wa5 allowed on the word so there was o lot of pressure on me while Sophie's dod ond older sister Amy were only Gble to join vio vldeo calls which were much tougherfor them to heor and understand the informotion. The third lockdown gave us some much-needed time together os o family where we could odjust to our new woy of life without the pressure of school. The downside wos we were quite isolated, t7nd Sophie was not oble to meet otherchildren with type I dit7bete5 or getsupportfrom widerfomily und friends. The Leed5 Children and Young People'5 Diabete5 Service are o brilliant team who ore very supportlve and olway5 available to help. But what we soon discovered was thot we Gre the experts. Sophie, like all children. is unique, ond olthough the hospital teom helps us with things like school care plans and reviewlng CGM doto, we ore best ploced to monoge Sophie's ¢ore- a 5totement we couldn't imagine 50ying only 10 months ago. We ore still leorning,. we ore still deoling with lots of firsts ond the voriety and combination of variobles that impactsophie's b1¢￿1 sugar levels. We found out obout the 'Comp in the Cloud, and were excited to do it ond enjoyed the doy participating in activities (J5 af¢7mily. Sophie andAmy both love dr17wing ond thoroughly enjoyed the comic book workshop. They were delightedsome of their creotions were selectedfor g type I comicl We want to enjoy oll the activities we did before andfor type I diobetes not to dictGTte our Ilves. We h¢7ve learnt that no two dgys ore the samel We know we still ht7ve morefirsts to come, but we are proud of where we ore now, olmost o year ofter diognosis." TRUSTEES ANNUAL REPORT 2021

Diabete5 RE5E8rch WELineSS Foundètio United Through Diabetes - #IOOYearsoflnsulin As 2021 was the centenary anniversary of the discovery of insulin, much of our 3wareness and promotional work was hinged Dn this historical breakthrough in the treatment of diabetes. To that end, we worked collaboratively with Closer Still Media to run a series of activities which commenced on World Diabetes Day, 14 November. Our activities began with a panel session, entitled 100 Years of Diabete5 Research - Past, Present and Future. A historic look back at the timeline of diabetes research Since the discovery of insulin and key advances to date. Discussion also explored clinical outcomes and patient benefits, and our hopes for the future through the continuation of research. Professor Emeritus David Matthews. Professor of Diabetic Medicine University of Oxford and past Chairman of the DRWF Research Advisory Board hosted the panel of experts which included, Dr Eleanor Kennedy DRWF Research Manager,- Dr David Strain, Senior Clinical Lecturer University of Exeter- Professor John Wildirbg, Professor of Medicine Institute of Life Course and Medical Sciences, University of Liverpool,. Dr Mark Evans, University Lecturer Iclinicall Department of Medicine, University of Cambridge- Dr Shivani Misra, Honorary Clinical Senlor Lecturer Department of Metabolism, Digestion and Reproduction Imperial College London and DRWF Trustee,. and Dr Chloe Rackham, DRWF Research Fellow, University of Exeter. Throughout the following week, we h05ted a series of live and pre-recorded l-hour evening workshops, which focused on several aspects of diabetes treatment, management and complications. These sessions were facilitated by numerous diabetes experts and attended by a wide mix of people with type l and type 2 diabetes, families, parents, carers and others. Additionally, we referred our audiences to a wealth of supporting resources including video and podcast content for further information. In total, 530 people participated In the event which was run over a 5-day perlod. Many of these people also revisited the pre-recorded content that was offered. Diabetes Professional Care-DPC Diabetes Professional Care 2021 For the past 6 years, DRWF has been a key supporter of Diabetes Professional Care IDPCI, an event that provides free to access CPD accredited education for healthcare professionals deliverin8 diabetes care. As the re8lStration sponsor for this event, we are well positioned to engage with the diabetes specialist teams and industry partners that facilitate and support this event. In 2021, we were able to re-establish a face-to-face connection following the tumultuous year of 2020. A total of 4984 healthcare professionals, from across the primary and secondary care spectrum, attended the event over the course of 2 days, benefitting from an educational programme facilitated by multi-disciplinary teams. The event was opened with a keynote session from Professor Partha Kar OBE, National Specialist Advisor Diabetes, NHS England and Profe550r Jonathan Valabhji, National Clinical Direttor for Diabetes and Obesity, NHS England and Improvement. What do people with diabetes really think Virtual consultations and telehealth are not about remote consultations? new concepts. however in 2020 with the advent of the pandemic, more people than ever were moving to 'remote' consultations. In order to avoid face-to-face contact in all but the most essential circumstances, digital consultation became mandatory rather than optional. Following this wholesale move, healthcare professionals and health organisatioris Started to look at the pros and tons of such consultation5 arnd commissioned surveys to assess user satisfaction. DRWF was asked to 5UPPOrt Anne Kilvert Diabetes Consultant, TRUSTEES ANNUAL REPORT 2021

DiabetES Resear¢h Wellness FouDdatyon Northamptonshire Community Diabetes Team, Daventry, UK Charles Fox Honorary Senior Lecturer. Leicester Diabetes Centre, Leicester, UK in their work to answer the question. 'what do people with diabetes really think about remote consultations?, The results of the study were published in Practical Diabetes Vol 38 No 4, 2021. Conclusions Without doubt, remote consultation5 will form a large part of diabetes care it) the future. These online and paper surveys demonstrate that many people with access to technology find virtual consultations very acceptable, but there are concerns about confidentiality, safeguarding and ability to comrnunieate or identlfy emotional distress. The DRWF paper survey provides important information about preferences, irrespective of acces5 to technologv. This may POTtly reflect differences between primary and secondary care, but personal preference was influenced by a wide range of factors. including time and travel,. confidentiality and safeguarding,. ability to be open and honest in either the virtua5 or face-to-faee setting. There is no 'one size fits all, and individual preference5 are not dependent on specifi categories, such as type of diabete5 or even access to technology. More work needs to be done to ensure that remote clinics meet the need5 of the whole diabetes population, in particular the provision of a 'safe space, for all users. Abstract 1 kn 2011 that￿5 ￿NIce fft Ne¢Awn rythed a pJsiti4t rv44)nse to a trial ol virtual clini(5 ' I￿t thLyr okvn NH5 trusl IBart5 ￿alth) 5tnJgJed to ewand the nwnber of viriual service5 offued.Vthon C'OVID stsu(k m Marth 2020, the NHS IrNnediatety cbtsined a Iicence io a secwe piadorm kv (OwN￿tatI(￿s." many apwinthwits k￿k place lry Pl￿ and the rwjmber of face.lO-f￿e d￿Ks dedined (trJnats(alty. people diabete5 Ptefer fa£trttrfac¢ vidEo consultatsons nd5 JsLWe swnmanse tht fird1ft￿ of Put￿lShed online suNeys arKI report ihe r(%ults of our 0¥￿ paFor ￿. dism￿led through the DIa￿leS Research & Wellw ￿￿￿latIon ffl￿thty ￿￿letter, DJaLYtQ5 Wellness New￿ Re5poMknts io the onli 5uf¥ryS t￿l￿Ve abxbt the tonefits of W￿al consultat￿￿ although thuc CO￿emS aM¥ut ccrfthdentkjlity. 5afeguar(hTh4 i&ntrfKatv)n ol tynoti(ffial 155ue In conwasl. the paw suNey In-3011 found that 91% of resF¥Jnthnts pre1c￿ed a lactrto-lace consultation. 36% of respmdents Kcess to ￿de0 iethrnlo￿, onty 1.2% had been ollered corsultrtr)n124% 3.8% with type 21 81% ol rernote co￿ulta1jOTrS had belm ￿ ￿One. While hvtrthiid5 01 re$F￿￿￿￿ we at least fairly saiislied w￿th thLr rernoie conyJlthtw& m05t wple wefwed w rewm to la￿ to lace tkn p055blo the MO￿ cornn reason ￿lrrf1 ihat communiotson wa5 eayer. In Condw￿. reff￿te c(x)sultats'orLS ￿11 iemain an ImFrfant tytson in the future. i th￿1 wekrences must be tkn Into acco￿1 a combinatity ol ￿mOte aThl face to face tht n￿1 effectsbt 0 2021 kthn Wiley & sons. Prtical D[aSe￿5 2021.. 38141.. 51-56 tm)le iknu¥J COV1tr19: COns￿la￿￿ welercnce5 KEY POINTS • ￿ (OVID pthc has wonyted a T4Md move 10 fertth cOnsultsth￿ lor pecFle th tha￿leS •IMme repyt a pofft w5e to ¥Kleo (cAwlial￿n5 bul exdude the ¥￿$01 Foe vthout &ce55 ID lechnd • A p4ei 5ur¥ry reveded ￿ oveThvhelming wdeTEnce lor fxtrto.face 4pointsnents wh pJssI￿￿ even aw I1￿￿e th) pjsstssoj the lethnDIo • A wde r￿ge ol la(tQ¥5 Infi￿￿e Inthwdual (1￿Ce IrKlude.' tsme travd.. ccfflfidenbality safe91a￿ry to be cpn and ￿est In eithty the wrtual or face-ITrIa￿ seuing • cor6￿￿￿On5 an cyuon bul ser￿e5 io adthess Indmdual need5 when offermg rerTrJte OT faCtrtrf￿e aFwntTM15. Many peopk may pteler a cD￿,.nBtrDn of b)th 10 TRUSTEES ANNUAL REPORT 2021

OTébere5 Research Wellness Foundation Research Funding Programme We provide research grants to researchers whose work we consider offers the best hope and most expedient path to improved understanding of all types of diabetes, new and improved treatments and management strategies, and ultimately a cure. Awards are offered as a 3-year Clinical and Non-clinical Fellowship and l-year Pump Priming project awards. Institutional and discretionary awards are available when funds allow. Contract funding of key personnel within the DRWF Human Islet Isolation Facility at the Churchill Hospital, Oxford 15 subject to proposal and review on a multi-year rolling contract basis. DRWF is a member of the Association of Medical Research Charities IAMRCI. a membership body representing the leading medical and health research charities who deliver high-quality research that saves and improves Ilves. Working with member charities and partners, AMRC aims to support voluntary sector effectiveness and advance medical research by developing best practice* providing information and guidance, improving publit dlalogue about research and science, and influencing government. As a member, we Subscribe to AMRC'S criteria for the use of peer review for allocating funding and support AMRC P051tion statements on the payrnent ofindirett cost51n universities and the use of animals in medical research which seeks to replace, refine and reduce the use of animals13Rsl in research. Our annual fundlng round Is offered through open competition, and as such. enables funded researchers to access support for both Indirect and direct costs of research via the Charity Research Support Fund ICRSFI and NIHR Clinical Research Networks ACORD agreement. We operate a rigorou5 peer review proce55 by which our Research Advisory Board, clinical and scientific experts in the field of diabetes and related health, assess applications and rewrts to ensure that only the highest quality and most effective research, carrled out usln8 good or best practice methodologies, receives DRWF fundin8. As an AMRC member we ablde by the five principles of peer review- • Accountability • Balance • Independence Rotation Impartiality amrc PEER REVIEW AUD, 2020 AMRC carry out an audit of member charities and their peer review processes every 5 years. The 2020 scheduled audit was delayed due to the pandemic and subsequently conducted during 2021. We were successful in achievin8 continued certification for best prattice in peer review. IE.I Universityof 2021 Sutherland-Earl Clinical Fellowship East Anglia We received 9 pre-applications for funding, from which 4 full applications were submitted. All 4 candidate5 were invited to interviews which were carried out by video call on 12 November. The Board of Trustees met on 7 December to review the recornmendation for funding and 5ubsequentlv agreed that the 3-year Fellowship be offered to Dr Tara Lee. University of East Anglia, for total of £237,007. Tara's work- DILIGENT: Use of Diabetestechnology on blrthweight. Labour. Inpatient and postpartum Glycaemia of pregnant WOMEN with Type I diabetes. TRUSTEES ANNUAL REPORT 2021

Diab•tesRe5eaich WellDe55 FouDthfion "De5Plte increosed use of continuous gluc05e monitoring (CGM} t7ndinsulin pumps, m05tpregnant women with type I di(Jbetes Struggle to monuge their glucose leve15 in pregnoncy. Many dellver large birthweight babies t7nd experience odditionul chullerjges mono9ing their diobetes during hospital GTdmissions and ofter birth. My project will examine how the mother s gluc05e levels and insulin therapy relate to boby's growth patterns and birthweight. It will also exomine which diabete5 technologies help pregnant women to t7chieve their glucose torgets during hospitol udmissions ond ofter birth. I will perform three 5tudies.- ftirstly, focusing on understanding baby's growth patterns, secondly on exominingmother's glucose levels during hospitol odmissions. labour und delivery, and thirdlyi during the six months after birth. My projert oddresses three top priority diabetes pregnancy research question5,' (l) use of diobetes technology to improve pregnoncy core.- (2) women's experiences and choices surrounding labour ond delivery ond (3) postnotul core t7nd support." Pump Priming 2021 A tota5 of 27 application5 were received for funding. Application5 were reviewed by the DRWF Research Advisory Board on 7 April with recommendations for funding approved by the Board of Trustees on 19, May. Six awards were offered totalling £119.696.00. Pump Priming project grants are considered 'proof of concept, awards and are funded for a period of i year to a maximum of£20,￿0 peraword. Dr Joanne Boldi50n, University of Exeter £19,989 Tltle: Single cell isolations from pancreatic tissue for high-dimen5ional immune profiling Type I diobete5 occur5 when the immune-5y5tem ottack5 a heolthy poncreas. Cells of the immune-system. invode the poncreos ond insulin-producing cells in the pancreas are destroyed, which result5 in a Ios5 of blood gluc05e control. To develop targeted theropyfor individuals affected by diabetes. we need to understand the immune cells that invode the poncreos. In humans, t7ccess to the puncreas is limited, however the QUOD 8ank supports Studies by providing tissue somples p05t- mortem. First, we will setup o new method to seporote immune cells from tissue somples of human p¢7ncreos to study different cell rypes, then develop sophisticoted onaly5es to evaluate our dota. so we are not bio5. To complement our approach, we will use the current method to study poncreatic immune cells from donor5 Wlth ditibetes. This funding will estoblish a new woy, using stute-of-the-ort technology, to evoluote the invading pan¢reotic immune cells in more depth." Dr Yu Hsuan Carol Yan& Unlverslty of Exeter £20,1]00 Tltle: Interventional neurobiology to regulate hormone secretion.. The critical role of galanin in pancreatic islet physiology -Sin¢e its discovery, the role of neurons in poncreos biology remoins controver5ioI. This Is in port due to the lock of tools requiredfor directlycontrolling pancreatic nerve5 andassessing the effects in living onima15. Zebrofi5h 5tudie5 are tron51atable to human development and diseose 9iven the high conservotion of organs ond physiology. I hove estoblished ossoys necessory for live zebrafi5h analysis of poncreas neurobiology and plon to implement these tools by torgeting neurons that produce the golanin neuropeptide. The pancreatic islets ore import17ntfor producing the hormone5 thot help regulote blood 9lucose levels. Following the increase or decrease in galonin signols, we will visuolize the effects on pancreotlc Isletformation ond octivity. The tools developedfrom these studies will be used to help us understand neural control of pancreas biology (including the regulotion of hormone relet7se} under normal ond diseased states.- Dr Nerys Astburyi Nuffield Departrnent of Prirnary Care Health Sciences, Oxford £19,985 ritle: Exploring the Long-term health Outcomes following a PrEgnancy with Gestational Diabetes Mellitus IELOPEGDMI UNIVERSITY OF OXFORD "Ge5tationol diobetes 15 aform of diabetes thot offects pregnont women. It usually goe5 awoy ofter birth. Getting GDM increoses the risk of problems during pregnancy and birth. There 15 Olso evidence that women who develop GDM are ot much higher risk of developing conditions like type 2 diabetes. But the effect of getting GDM on other condition5 as well os on the health of the baby has not been widely investigated. 12 TRUSTEES ANNUAL REPORT 2021

DiabetEsRe5ea￿h 8Tr Wellness FDundatton Using one of the UK s largest datob05es of routine heafthcore records we will met75ure the effect getting GDM has on heolth ond disease risks in mothers ond their bubies. Insight into thefull efferts thot GDM hos on women and their babies will provide o boost to research effortsfor the early detettion, prevention and treotment of GDM.- Dr Astrid Hau8e-Evans, Unlversity of Roehampton £20.(I)O Universityof Title: A novel and sex-specific role for LEAP2 in the regulation of pancreatic islet Roehampton London function "Both obesity and increased blood sugar are importont foctors in the development of type 2 di17betes (T2DJ. They are controlled byhormonessuch a5 insulin and ghrelin. Ghrelin stimulutesfood intake, promotes weight goin and inhibits insulin secretion from islets in the poncreas, which in turn leod5 to higher blood sugur levels. Torgeting ghrelin action may therefore be a way of preventing Dr treating obeslty und/or T2D, but so far no useful pharmoreutiC171 blocker5 of ghrelin hove been discovered. Importontly, o newproteinfrom the liver ondsmall intestine has now beenfound to counteract the effects of ghrelin. Our initiol experiments suggest thot this SrnGTII protein, Liver-Enriched Antimicrobiol Peptide-2 ILEAP2), stimulates Insulin secretion. Interestingly. this action differ5 between mt71es andfemales. Our study will investigate the role of LEAP2 in regulating blood 5ugt7r levels. focusing on sex-specific difference5 ond the woy this peptide offects pancreotic isletfunction. Dr Richard Hulse, Nottingham Trent Unl¥er51ty £19,760 University of Title- Functional signiflcance of HIFlo activated dorsal horn 5ens0ry neurons in Nottingharn the manifestation oftype 2 diabetic neuropathlc pain LIK ,' CHINA MALAYSIA We have shown thot in type l ond 2 diobetes, if the spinol tord Sensory neuronsfoll to receive blood, they become domaged ond long-105ting puin develop5. We think that pain develop5 in diabete5 a5 reduced bloodflow prevent5 oxygen getting to the spinal cord. Pain signols ore generutedin our honds andfeet. trovel along sensory nerves until they reach the spinal cord, where poin informotion isfiltered. Spinal cord sensory neurons norm?Ily turn thi5 signol down or off. In diabetes these neuron5 105e their obility to turn pain 5igna15 off, resulting in people with diobetes feelirjg poin. It is currently unknown why these neurons chonge theirfunction. HIFla i5found in neurons when there 15 reduced oxygen. A mouse model of Type 2 diobetes will be used ond, in these animals, I will stop them producing HIFlc¢ in the neurons, ro prevent dlobetic neuropothic polnfmm developing." Newcastle Dr Guy Taylor, Newcastle University £19,962 University Title: REBEL - CV study.. Does Residual P-CELL function and exercise offer synergistic protertion against hyperglycaemic induced Circulating Vaso protective dysfunction in type I diabetes? °For people with TID, exercise is beneficiol, potentiolly reducing the progression of diabetes-reloted complicotions. Mony people (up to 80%) with TIDstill releose smollomounts of in5uIAn together with C-peptide, a molecule involved in the creation of insulin, from the poncreas. This moy also help protect against diabetes complicotions, olthaugh exactly how is currently unknown. One p055ible woy is through endothelial progenitor cells (EPCS), which circulate in the blood and repoir blood ve55els.' with fiD a550CiOted with hoving lower numbers of these important cells. We have recently discovered thot individua15 who no longer produce uny insulin/C-peptide ore not able to increase the number of EPCS ofter exercise. compared to those who still produce insulin/C-peptAde from the pt7ncreas. We propose exploring how hovin9 some obility to still moke insulin/C-peptide MJV influence how well EPCS work in normal ond high blood glucose conditions, ond whether this works in combinotion with exercise." 13 TRUSTEES ANNUAL REPORT 2021

Oia*te5Re5èarchEt we￿nesSFDUThdarIon Islet Cell Research & Transplant DRWF has made a considerable contribution to the funding of islet cell research and transplant in the UK and around the world. The DRWF Human Islet Isolation Facility at Churchill Hospital, Oxford plays a pivotal fole in providing islets for research and transplant a5 part of a national treatment programme. the clinical element of which is funded by the NHS. UWIVE851TY OF OXFORD Three personnel are funded within the facility (around 30% of facility staff): Lab Manager Deputy Lab Manager Ipost doc researcher) Islet Transplant Co-ordinator Durin8 the year, we renewed oijr commitment to the Lab Manager post with a further 3 years funding totalling £228,752. Dr Stephen Hughes, long-standing Lab Manager retired in October having been funded by DRWF since the facility was launched in 2006. Dr Rebecca Spier5 takes UP this posltion with the ongoing commitment of DRWF funding. Additionally, we aBreed a no-cost extension to funding in place for the Deputy Lab Manager post which remained vacant in 2021. We expect this post to be filled in early 2022. The funding for the Islet Transplant Co-ordinator position will be revisited when the current award terminates on 30, April. 2022. Impact report from the Director of the DRWF Islet Isolation Facility Churchill Hospital, Oxford by Professor Paul Johnson During the pandemic, the Universlty closed many of its research facilities for various periods of time. This has limited our research activity, but the team has continued to be research active whenever this has been possible. We continue to undertake novel research into the development of physiological islet scaffolds and islet macro-capsules, design of a novel islet culture, and optimisation of islet QXy8enation including proteomic characterisation during islet isolation. We were a key partner in a Horizon 20120 European Grant and continue to be central to two themes ISur8ical & Diabetes) of the Oxford Biomedical Research Centre. The Oxford DfiwF Isolation team have continued to be highly recogni5ed in the islet transplant and islet research rields. Professor Paul Johnson has continued to Chair the NHSBT UK Islet Transplant Steering Group throughout this difficult time. This h35 involved close liaising with the NHS and difficult decisions about keeping islet transplant recipients safe. He has continued to give invited lectures to learned societies, albeit increasingly in a virtual format. Team members have continued to present at international scientific meetings and continue to publish work regularly in peer-reviewed journals with appropriate DRWF atknowledgement. We have already started to see the return of normal islet isolation activity and have started to reattivate our islet transplant recipient list. We have just started an exciting new initiative with NHSBT called 'lncrea5ing the Number of Organs Available for Research, IINOARI. Thi5 important project will enable donor organs from donors with diabetes to now be retrieved routinely from across the UK for research purposes. Up until now, this has been very sporadic and there has been no infrastructure for research retrievals. The Oxford DRWF Islet Isolation Facility will lead an '151et Platform, with responsibility for isolating and distributing islets for research from these rare pancreases. This will be a unique resource for researchers as they try to find a cure for diabetes. The 'lslet Platform, ha5 only been made possible a5 a result of DRWF'S long-term partnership with the Oxford Facility. The impact of an Islet Transplant- 14 TRUSTEES ANNUAL REPORT 2021

DiabetE5 Re5pèrth ep Wellrness Foundaiio The journey of a transplant recipient- -1 become diobetic ot the oge of 19following o virol infertion, it Ct7me os o shock 05 there wos no history of diabetes in myfamily. However. once diagnosed I was determined thot diabetes would not define my life ond l ensured I h¢7d good control and leod ofull and active life. Once I hadmy children. mydiobetes controlbecorne challenging. particularlyin recognising hypos. Suddenly I wos not gettin9 the symptoms. ond this was leaving me vulneroble. This was life changing for myself ond for myfomily, it begon to limit whot we ftlt it was sofe for me to do. Eventually. the lack of hypo t7woreness led to a seriously low episode where l ended up in A&E. After this we se￿-fUnded o CGM which helped me stoy 5ufe ond manage my glucose control. I wGr5 under the care ol Good Hope Hospltal. and I will olway5 be grateful to my con5ultont ot the time. He acknowled9ed my struggle with hypo-unowarene55 and talked to me obout on islet tron5plant. which wos ground-bret7king ot the time. My hu5bond ond I met with him severol times before deciding to speak to Professorjohnson ond his teom. who gove us a detoiled explant7tion of the procedure, the benefits ond the risk5. After corefvl considerotlon, I decided thot it W05 the correct course of oction for me. 05 my life hod become very limited, ond I hod a strong fear of losing myfuture independence. I welcomed the opportunity to explore this exciting pr05pect. After comprehensive testing to ensure I w175 phy5iC¢711yfit enough to hove the transplont I was put on the waiting list in 2012 and had mylir5t Islet tronsplgnt in Ortober 2012. This sow o reduction in insulAn, gnd I begon to get my hypo awareness bock. The proce55 is not eosy, ond l initially struggled with the immunosuppression toblets, but the level of support ond care from the 8irminghom and Oxford team was phenomenal. In April 2013, 1 hod my second tran5plont. and this wos the life chonging tronsplantfor me. Slowly, but surely working veryclosely with the Oxford teom. (who were therefor me. even 17t the weekend5), I took myfir5t step5 to being Insulinfree. I cannot describe the Immense elotion thot bought me and myfomily. To eot o sondwich ond to See my islet 5elf-coffect my glucose wos life ch17nging. l ensured I looked ofter the islets well and wus very corefulobout whot l ate. ensuring I did not over stress the islets. My islet tronsplonts brought me as well os myfomily newfoundfreedom, ondfor thefirst time in o long time my husband could go to work without worrying about me ond I could forget about being diabetic. It truly wos omozing. I wos o Deputy Heod Teocher ot o Primory school ot the time olmy tronsplont ond believed that becou5e of mypoor hypo oworeness, I would not be oble to take the step into heodship. However, following my tronsplont I hod the confidence in my heolth to t7pplyfor the position ond have been in thut rolefor nearly six yeor5. I hodfive wonderful yeors insulin free, but Slowly my islet funrtion Slowed down ond overtime, I had to move ont? Using more insulin. Having recently hod COVID, this led to a significant loss of function, cnd l om now back on an insulin pump. Although this did bring some heartuche ut the time, l omfull of grotitudefor my time without insulin ond to the wonderful teom who supported me. My life is still much better than it wos bock in 2012. 1 om independent ond still hove hypo awareness, which wos the moin gool of the tronsplonts. Ifeel ble55ed to hove been given this opportunity ondhope that mony diabetif5 like myself get the same chonce.- Ann 15 TRUSTEES ANNUAL REPORT 2021

DiabEte5REseaich E* Wellne55 Foundatio How we raised our money in 2021 Our approach to fundraising- The Trustees are aware of their responsibility and accountability to ensure that the charity fundraises legally. responsibly and effectivelv. Our plan for 2021 was to maintain focu5 on building resilience and sustainability for the future through succession planning, diversification of income streams and delivery of purposeful programs that continue to meet the ever- changing needs of people with diabetes. In the hope of returning to more normal levels of artivity in 2021. we Set our sights on an ambitious income expectation. This was to support a higher level of expenditLbre that would occur in the year, particularly in the payment of researth gr3nt5 which had seen an unprecedented level of no-cost extension requests, due to the inability to carry out research work in 2020. However, it was tlear early in the year that our activlties would continue to be impacted by Covid-19. Community engagement was still affected with our inability to run both in-person Wellrbe55 Day programme activitie5 and fundraising events in any meaningful way until late Julylearly August, when we started to see a marked increase in Interest. Additionally, there was the global impact of supply and shipping issues to navigate which had a significant effect on our Direct Mail programme, causing us to refine the volume of campaigns distributed during the year and manage a few delays in campaigns being mailed. Direct Mail continues to be the mainstay of our donation related fundraising activity along with Regular Giving and associated Gift Aid. Whilst we saw an increase in the number of deceased notifications received in the year, our committed supporters continued to contribute in response to direct mail appeals with net average gift5 maintaining pre-covid levels. Attrition in our Regular Giving programme was Stable at around 7%, as has been the case for the past 5 years with most of the attrition relating to deceased notification rather than direct cancellation of support. Whilst unpredictable in nature, legacies increased significantly in the year and accounted for around 53% of total income. We have identified numerous Opportunities to diversify and develop our income streams and are focused on lrnplementing new strategies to strengthen income through all Channels. Income 2021 Re8ular Glvlng Gift Aid. 6% Re8ular Givln& 8% • General Donatlons Genèral Donatlofis, Ix Oirect Mall Lottery Prograrnme Communlty Fund Raisin8 Grants & Trusts DWN Subscriptions Dlrett Mall. 26% legacies Gift Legacies. 53% Community Fund Raising, 3% Other Income Grants & Twsts. 1% 16 TRUSTEES ANNUAL REPORT 2021

OiabEle5 Re5*arth & WelLness Foundaiion Corporate Partnerships: We do not endorse products. but we will support initiatives that increase awareness to DRWF and our activities, and where there is an appropriate message. product or service for people with diabetes. To this end, we have worked to explore meaningful partnership and corporate sponsorship opportunities, where there is a synergy in mission, vision and values. Any potential partnership is assessed for feasibility, compatibility with our own objective5, and risk to ensure there is no detrimental effect to our reputation or fundraising potential. Robust risk assessment supports our desire to only engage in suitable and best value partnerships. Detailed disCUS5ion and negotiation ensure that the aims of both parties are complementary and mutually beneficial. Thi5 maintains transparency and integrity in all partnerships. Professional Fundraisers: We did not work with a professional fundraiser during the year. Commercial participation agreements are in place where necessary. We can't do this without our amazing supportersl With the continuation of the pandemic and a$50ciated restrictions, much of our planned community fundraising activity was curtailed until the summei months. In August and September, when Covid restrictions had become less Stringent, people slowly started to undertake activities outside of their computer5 and gardens. We continued to rely on committed supporters coming up with novel fundraising ideas, to generate awareness and financial support for our ongoing operations. Suson Dixon, selA-confessed adrenalin Junkie abseils the Spinnaker Tower. Suson Dixon celebrated her 70th blrthduy by toking on a 100-metre ab5ell down the Spinnaker Tower. Portsmouth's iconic landmork, with twofriends to roi5efundsfor DRWF. Susan. a retired WREN. saidshe loved the experlence.. "l always wonted my family to look up to me. It wentfar too quicklyfor me, ond I think I'll hove to do it againl" On her reosonsfor sUPPOrting DRWF. 5u5on said.. "I know too mony people Ilving with diabete5. ondl wonted to n115e the profile of this locally based charity ond boost theirfunds to help more people.- Sust7n abseiled with goodfriends Dotty Jockson ond Charlene Pirie 05 Port of a team tofundroisefor DRWF. Su5t7n is no stranger to uttempting new chollenges on londmark anniversories. Itstorted with o pt7rachute jump when She Wt75 40 17nd o trip on the Route 66 across the United States oged 66. The Spinnoker Tower obseil has now got her thinking obout doing o tondem porochute jump next. TRUSTEES ANNUAL REPORT 2021

OTiberesResearch Et Wellne55 Founda¢Ton Penny Durrant and her daughter Sophia decided to go for a close shave and keep a cool head in support of son. Charles. who has type I diabetes. A mother 17nd doughter shoved their hecds to raise money for DRWF to r0i5e aworeness about type I diobetes. ￿ke mony people living with type I diabetes. Charles Durront. hos experienced some difficulty keeping controlof his bloodsugorlevels during warmer weother. His mother and sister. Penny ond Sophi Durrant, felt one way to combat the heot. in solidority with Charles, would be to keep a cool head - ond so they shoved off their hair. Charles was diognosed with type I diabetes when he was aged 12- he is now 25. Penny said. SophiGr ond I shovedourheods ond wore DR WF t-shirts. We ore both loving how eosy It is to not hove much hair. My son. Charles, was diagnosed with type I diabetes oged 12. He hud been con5¢17ntly thirsty and urinoting frequently- retOgnised5ymptom5 of type I diobetes. 1 took him to the GP ond we were sent stroight to h05Pltal. His blood sugors were so high thot the hospital couldn't get a reading on them. 114 Dlaveies Weiine D li-t*) ',%FoundoTlOn Charles stoyed infor two or three days leorning how to do his insulin injection5. We were given an emergency insulin pen ond I wos told how to Use it and warned of the risks that Charles could possibly go into o coma if not in control of the condition. Charle5 has been really struggling lately with his blood sugors going too high ond then dropping down low into a hypo (hypoglycaemic episode- low blood glucose leve15). I think the heot IS to blame. Fundraising Regulator.. WÈ are a levy-paying member ofthe Fundraising Regulator and subscribe to the associated fundraisin8 codes of practice. The charity suppresses individual supporter records against the Mailing Preference Service, Telephone Preference Service and the Fundraising Preference Service. which helps to ensure that we do not approach individuals who have expressly requested that we do not contact them. During the year, we were notified of 21 FPS requests, which are suppressed from all contact, 20% less than received in 2020. Complaints: The charity has a published complaints procedure. available on its web51te, and endeavours to respond to enquiries and complaints within the stated timeframe. Most contacts tend to be a request to opt-out of charity communications by existing supporters and we monitor the basis on which people request this i.e. content of appeal, volume of contact.. type of contact. method of contact to inform our campaigns with the aim of reducing ?ny perception of unreasonable intrusion, persistent approach or undue pressure to support. We received I complaint about our fundraising practices during the year, which wa5 5at15factorily resolved. GDPR and Data Protection: We are committed to proterting the personal information and privacy of individuals that we engage with and comply with relevant legislation and codes of practice. whilst carrying out our essential work of raising awareness of diabetes. providing information and support, and raising funds. Our privacy policy, published at drwf.org.uk sets out how we capture, process. manage and retain personal information. Additional security measures were put in place to ensure that remote working practices remained GDPR compliant. The team also undertook GDPR refresher training during the year, facilitated by Hybrid Legal. 18 TRUSTEES ANNUAL REPORT 2021

Diabetes Rese4rth Wellness Foundation Financial Review Principal income streams in the year were direct mail campaigns: regular giving via direct debit,. legacy income and gift aid associated with voluntary donations. During the pandemic. we adopted 3 5hort-term reactive. medium term pro-active and long-term strategic approach to manage the many challenges that we encountered across the year. Income and expenditures were monitored on weekly basis with budgets/forecasts adjusted accordingly. Total income was £1,686,061. This was a decrease of 21rk on budgeted income but an increase of 0.8% on income received in 2020. Voluntary donations including gift aid receipts at £1,665,724 was up by 1% on 2020. Legary income, having been bud8eted for very cautiously on notes of intent only, was £882,536, down by 3.5% on budgeted income. and £132,726117.7%1 more than received in 2020. Total expenditure in the year at £1,900,422 was 12.0% below budget but an increase of 13.5% on expenditure in 2020. At year-end we were showing a deficit of £214,361. This w35 £162.206 more than the deficit we had budgeted at £52,155. Direct charitsble expenditure was 84p in every £1 spent184p in 20201. Government Grants The charity made use of the Government's Klckstart Scheme to fund digital lobs for six months for 16- to 24-year- olds on Universal Credit. £20,336 was claimed under this scheme. A £212 SSP Covid-19 rebate was also tlaimed to claim back employees, statutory sick pay related to Covid-19. Investment Policy Under the Memorandum and Articles of A550Clation, the charity has the power to Invest in any way the trustees see fit. The trustee5, in order to minimise to risk and having regard to the liquidity requirements of the charity, and to the reserves policy, have historically operated a policy of keeping available funds in a higher interest-bearing deposlt account seeking to achieve a rate of deposit interest which matthes or exceeds inflation a5 measured by the retail prices index. The trustees have regularly reviewed opportunities to increase investment return from short-term, easy access, options bearing in mind the desire to ensure that we can react quickly to appropriate request5 for addltional research support as they arise. The trustee5 are also conscious of on-going cash-flow requirements durin8 a challenging time where historical fundraislng methods are raising less income and where new methods of fundraising are being tested at higher cost. All things considered, the trustees believe it appropriate to continue to explore investment opportunities as they present themselve5, Wlth a view to maximising return on its deposits. Reserves Policy To safeguard the need for sufficient funds to cover on going management, administration and support costs. as well as respond to further grant requests that might arise, the Board aims to maintain unrestricted, free reserves at a level that equals 3-6 months of operating and charitable expenditures, which equates to between £558,993 and £1,117,986. During financial year 2021, total expenditure was £1.900.422. Allowing for adjustments and forward research commitments, the charity's expenditures for financial year 2022 are likely to be in the region of £2,235,970. At 31" 19 TRUSTEES ANNUAL REPORT 2021

DiabEte5Aesearch Et WÈllnes5 Foundation December 2021. the charity held free reserves lunre5tricted reserves le55 fixed assets) of E2,751,693. This is the equivalent of approximately 15 months operating and charitable expenditures. The trustees are committed to strengthening existing income stream5 whilst diversifying fundraising activities to reduce reliance on single sources. It is accepted that this will take investment in activities where the accuracy of predicting response rates, in terms of volume or value of gift, will be more challenging in the first instance. Current reserves, whilst in excess of those anticipated, will enable us to navigate these more challenging times whilst diversifying income generation and developing the charit¢s objective activities, for future 5ustsinabilitv. Going concern The trustees consider that there are no material uncertainties about the charitVs ability to continue as a going concern. The trustees have made this assessment for a period of at least one year from the date of the approval of these financial statements having considered known commitments. forecasts and projertion5 and possible pre5sure5 on income generation. After making these considerations. the trustees conclude that there is a reasonable expectation that the charitable company has adequate resources to continue in operational existence for the foreseeable future. The charitable company therefore continues to adopt the going concern basis in preparing the financial Statements. Our focus in 2022 and beyond The pandemic period of 2020121 has shown us the need to be a8ile, inte8rated and adaptive in our approach. Whilst the past year has been incredibly challenging. we have been resourceful where possible and gained invaluable experience that will help us reconfi8ure our approach to 'what good looks like, for DR WF, our supporters and beneficiaries. To this end, we have stoped out a 3-year growth strategy which clearly define5 our vision. mlsslon and values and the direction that we will take to build a robust organisation that is well-positioned for the future. Through the work of our Core Fundraising Group, we have identified numerous ways in whlch to refine and develop existing fundraisin8 activities to enable us to strengthen and diversify income streams. Through our Wellness Action Group. we have engaged with a broad spread of beneficiaries to discuss current DRWF service/support provision; the availability of support and resources in the wider diabetes community,. opportunities a nd threats to current activities and woys in which to develop and expand on our portfolio of programmes. Whi15t current reserves are in-excess of the operating and direct charitable expenditures required to meet the stated 3-6-month policy, it is expected that investment will be required to test and develop new income streams over time, whilst allowing us to navigate fluctuations in current activities and remain responsive to requests for discretionary research funding. The Trustees will consider designating a percentage of current reserve5 to support investment in our growth strategy in 2022. Our focus is very much on ensuring that we have the ne￿sSary funds to build a resilient and sustainable organisation that can meet the ongoing, and ever-changin& needs of our beneficiaries. 20 TRUSTEES ANNUAL REPORT 2021

abEtesfl*search El Wellne55 FoundaiiDD Reference and Administrative Details Charity Number.. 1070607 Company number: 03496304 Registered Office.. Building 60CKI Langstone Technology Park Havont. Hampshire P09 ISA Tel.. 023 92 637808 Website.. drwf.org.uk Trustees & Directors.. Mr W. Michael Gretschel Ichairrnanl Mr John Alahouzos Mr Jeffrey Harab Mrs Valerie Hussev Mr Steve Jones (elected October 20191 Dr Shivani Misra lelected January 20201 Chlef Executive: Mrs Sarah Tutton (Bonel Advlsers Bankers.. Barclays Bank PIC I Churchill Place London E14 5HP Solicitors.. Blake Morgan LLP New Kings Court Tollgate Chandlers Ford Eastleigh S053 3LG Secretary: Blake Morgan Company Secretary SeNices Auditors: Moore Kingston Smith LLP Devonshire House 60 Goswell Road London ECIM 7AD 21 TRUSTEES ANNUAL REPORT 2021

Diabe￿Re5e4rth Ey WellThe55 Found4tiDn Structure, Governance & Management Governing Document The Diabetes Research and Wellness Foundatlon, a150 known a5 DRWF, is a registered charitable company (Registered Charity No.1070607 and Company No 034963041 limited by guarantee and governed by its Memorandum and Articles of Association dated 15 January 1998 and amended by special resolutions passed on 15" June 1998, 2 December 2Crt)l and 24 April 21X)5. Recruitment & Appointment ol Trustee5 The charity trustees are also the directors of the company for the purposes of company law. As dlctated by the charity's Articles of Association. directors are appointed by the Company Members. Any person desiring to be admitted to the membership of the company is required to apply in writing. No person shall be admitted until approved by resolution passed in accordance with the Articles of Association by the existing members. who hold absolute discretion as to the admission of any person. The Trustees of the charity, being mindful that the board should offer a diversity of skllls to fulfil statutory and fiduciary duties. ale open to recommendations for new board members. The business and medical/health related skills within the existing board mernber pool are supported by personal experience of diabete5. which a55lSts the board in ensuring that objective activitie5 meet beneficiary need. Addltionally, the board Is supported in its decision-making processe5 by a Research Advisory Board, which has an independent Chairman. The RAB members review applications and make recommendation for research funding awards. An Editorial Advisory Board provides support to the provision of health and social care information. Both boards are made up of clinicians, scientists and other 'eKpert5' in the field of di3betes and related health and strengthen the services that the charity offers its beneficiaries. All board members are subject to 'conflict of interest, policie5 and processes. Trustee Inductlon and Training - Newly elected Trustees receive an Induction Pack that outlines the role and responsibllities of the Trustee. along with a history of the structure and purpose of the charity. The pack includes a copy of the governin8 document and contact deta115 of all board member5. There Is also an outline of the Chairman of the Board's role and responsibilities along with details of the executlve officer taking responsibility for the daily management of the charity. Trustees ore required to comply with the eligibilitv requirements set out by Charity Commission and to review and update an annual Register of Interests. Trustees are kept up to date with various governante publications and notices from appropriate professional advisory memberships. Additionally. trustees might be advised of appropriate governance courses that they may benefit from attending to ensure diversity and continuity of knowledge and skills within the Board. Newly elected trustees are invited to attend a Review Meeting with the chair, after an agreed time lapse, in order to feedback their first impressions and addre55 any concerns. Trustees are attively encouraged to participate in the charity's outreach programme of educational events. Organisation The strategic direction and policy of the charity is the responsibility of the Board of Trustees. During 2021 51X trustees served on the Board. from a variety of professional backgrounds relevant to the work of the charity. Ordinari Iv. the Board meets at least once each year in person and holds qLsarterly teleconference meetings with additional meetings organised as required. Due to the continuation of coronavirus and ever-changing restrictions, the Board continued to conduct meetings via Zoom. There were no meeting5 in-person during the year. The Chief Executive carries out the daily operations of the charity and 15 ie5ponsible to the Board of Trustees. 22 TRUSTEES ANNUAL REPORT 2021

Diabpie5 Research t* Wellness Foundation Connected & Related Partles - DRWF co-operates on several intellectual matters including sharing articles and report5 Wlth the Diabetes Research and Wellness Foundation Inc.. a 501C3 Not for Profit Company operating in the United States- Association pour la recherche sur le diabete (A-rdl in France- Insamlingsstiftelsen Diabetes Wellness Network Sverige (Swedenl,. Diabetes Wellness Suomi IFinlandl and Diabetes Wellness Norge (Norwayl. These organisations are completely autonomous and independent with no legal connections. Mr. W. Michael Gretschel is the Chairman of the Board of Trustees of the Diabetes Research and Wellness Foundation and is the volunteer President of the Diabetes Research and Wellness Foundation Inc IUSAI but does not serve on its board of directors. He is also a Board member of A-rd (Francel. DWNS1Swedenl, DWS (Finlandl and DWN (Norwayl. Mr. John Alahouzos is the Chairman of the Diabetes Research and Wellness Foundation Inc IUSAI and serves on the Board of Trustees of the Diabetes Research and Wellness Foundation. He also is a Board member of A-rd IFrancel, DWNS (Swedenl, DWS IFinlandl and DWN INorwavl. Mr. Jeffrey Harab sits on the Board of Trustees of the Diabetes Research & Wellness Foundation and is also a Board member of A-rd (Francel. Mrs. Valerie Hussey slt5 on the Board of Trustees of Diabetes Research & Wellne55 Foundatiorb and is also an 'alternate member, on the Board of DWNS Iswedenl. The Chief Executive of the Diabetes Research & Wellness Foundation, Sarah Tutton, sits on the Board of DWN (Norwayl. Llnks between these independent organisations, has proved invaluable to the charity in helping to strengthening it's international presence, for rhe purpose of supporting diabetes research programmes and global awarene55 activities. A Reglster of Interests for 8oard Members and Key Management Personnel is maintalned and reviewed on an annual basis. Remuneratlon Pollcy for senlor staff - The Trustees, who are also the directors, and the Chief Executive Officer comprise the key management personnel of the charity in charge of directing and controlling, running and operating the charity on a day-to-day basis. All trustees give their time freely and no trustee received remuneration in the year. Details of trustees, expenses and related party transaction5 are disc105ed in note 13 to the accounts. The salary of all staff, intluding the chief executive officer. is reviewed annually and normally increased in accordance with average earnings. In view of the nature of the charity, its size and structure, the trustees undertike a benchmarking exercise, using online research/too15. comparing the charivs salaries against pay levels offered for similar roles within other charities and companies. The benchmark is the mid-point of the range paid for these similar roles with consideration given to workload, level of responsibility, anticipated rate of inflation and other published research on third sector rates of pay. The charity considers thot its remuneration policy- Ensures delivery of the charivs objectives Attracts and retains a motivated workforce with the skills and expertise necessary to ensure organisational effectiveness Is equitable and coherent across the org3nisation Reflects the purposes. aim5 and values of the charity Ensures that pay levels and pay increases are appropriate in the context of the interests of our beneficiaries 23 TRUSTEES ANNVAL REPORT 2021

Dilbetes ReytJith & Wellnes5 Fvundatian Rlsk Management- The Trustees have examined the major strategic, business, reputational and operationa1 risks that the charity faces. This involves identifying specific risks,. assessing their likelihood of occurrence and potential impact.. determining what steps could be taken to mitigate those risks and delegating responsibility to key staff for overseeing management of the associated controls. The risk register is reviewed annually to ensure the adequacy of internal control mechanisms. The trustees consider that the Charity has robust internal procedures, systems and processes and believe that risk assessment is embedded throughout the organisation. The risk register wa5 reviewed and scored in September and resulting risks discussed by the Board at a meeting held on 28, October. There were several risks which ranked as MEDIUfvI13- 5 amber) where additional control measures or alternative methods of working may be required, and these are being monitored. There were no high-level risks (score 6-91 identified during the review. The higher-ranking risks identified in 2020 were largely related to buslness-continuitv during the initial pandemic period. These risks have now reduced in score. The Board considers that the major risks facing the charity at present, are- Fundraising and dependency on single income streams Data security including loss of data Loss of key staff Reserves policy and cash flow sensitivity Government policy Disaster recovery The charity is focused on diversifying artivitie5 to reduce reliance on unpredictable or single income stream5 Wlth 'Core Fundraising Group, meeting monthly to review and develop strategy to support this. We are conscious that any major fluctuations in our biggest key streams will impact on our reserves and potentially affect our ability to deliver on purpose-related activities. As a small team of staff. the loss of any one of the team would have a considerable impact on our ability to carry out certain activities. To support retentlon, we have implemented several 'motivational mapping, exercises over the last few year5 to ensLbre that we play to individual Strengths and retain expertise. Equally our remuneration policy is designed to ensure that we attract and retain staff. However, we are putting in additional contingency measijres by way of out-sovrced service support where appropriate. We continue to monitor external factors through business continuity planning. Covld-19 rlsk assessmentlbusine55 continuity When the impact of Covid-19 hit in 2020, we developed a pandemic response/business continuity checklist that outlined key considerations to help us mana8e- Health and safety of employees Critical activities Dependencies- staffing Key suppliers/contractors Idisaster re¢overy/bu5ine5s continuity plansl Communications strategy Technology requirements Activation plans This has served as an effective way to manage the risk and potential impact on employees, stakeholders, beneficiaries and our key activities and we continue to work within this risk management framework. 24 TRUSTEES ANNUAL REPORT 2021

DiJestte5e4rch Wel￿￿55 Foundipn Trustees, responsibilitles in relation to the financial statement5-The trustees, who are also dirertors of Diabetes Research and Wellness Foundation for the purposes of company law, are resFionsible for preparing the trustees, annual report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards Iunited Kingdom Generally Accepted Accounting Practice.} Company law requires trustees to prepare financial ststements for each financial year that give a true and fair view of the state of the affairs of the charitable company and of the outgoing resources and application of resources, including the income and expenditure. of the charitable company for that period. In preparing these financial statement5. the trustees are required to: select suitable accounting policies and then apply them consistently. observe the methods and principles in the Charities SORP. make judgement5 and estimates that are reasonable and Prudent. state whether applicable UX Accounting Standards have been followed, subject to any material departures disclosed and explained in the financial statements. prepare the financial statements on the going concern basis unless it 15 inappropriate to presume that the charitable company will continue in business. The trustees are responsible for keeping proper accountin8 records that disclose with reasonable accuracy at anv time the financial position of the charitable company and enable them to ensure that the financial statements comply with the Companies Art 2W6. They are also responsible for safeguarding the a55ets of the charitable company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities. In $0 far as the trustees are aware: there Is no relevant audit information of which the charitable compan¢s auditor is unaware; and the trustees have taken all steps that they ought to have taken to make themselves aware of any relevant audit information and to establish that the auditor is aware of that information. Audltors - Moore Kingston Smith LLP have indicated their willingness to continue in office and are deemed to be reappointed in accordance with section 487121 of the Companies Act 2006. Small Company Exernptlon- This report has been prepared in accordance wtth the special provislons of Part 15 of the Companies Act 2006 relating to small companies. On Behalf of the Trustees 04-D5-1011 Mlchael Gretschel Chairman Dated 25 TRUSTEES ANNUAL REPORT 2021

INDEPENDENT AUDITOR'S REPORT TO THE MEMBERS OF DIABETES RESEARCH & WELLNESS FOUNDATION Opinion We have audited the financial slalements of Diabetes Research & Wellness Foundation I'the company'l for the year ended 31 December 2021 which comprise the Stslemenl of Financial Activities, the Summary Income and Expenditure Account, the Balance Sheet, Ihe Cash Flow Slalemenl and notes to the financial statements, Including significant accounting policies. The financial reporting framework that has been applied in their preparation is applicable law and Unrted Kingdom Accounting Standards, including FRS 102 'The Financial Reporbng Standard Applicable In the UK and Republic of Ireland, (United Kingdom Generally Accepted Accounting Practi￿1. In our opinion the financial statements.. give a true and fair view of the stale of the charitable company's affairs as at 31 December 2021 and of it5 incoming resources and application of resources, ir¢cluding its income and expenditure, for the year then ended, have been properly prepared In accordance with United Kingdom Generally Accepted Ac¢ounling Practice,. and have been prepared in accordance with the requirements of the Companies Act 2006. Ba$1$ for oplnlon We conducted our 8udil in accordance with International Standards on Auditing {UKI IISAS IUKII and applicable law. Our responsibilities undef those stsndards are further described in the Auditor's Responsibilities for the audit of the financial slalemenls section of our report. We are Independent of the charitable company in accordance with the ethical requirements that are relevant lo our audit of the financial statements in the UK. inclu(Jing the FRC'S Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements We believe that the audit evidence we have obtained is SUff￿lent and appropriate to provide a basis for our opinion. Concluslon8 relatlng to golng ¢oncern In auditing the financial statements. we have concluded that Ihe Iruslee$' use of the going concern ba515 of accounting in the preparatson of the financial stalemenls is appropriate. Based on the work we have Ferformed. we have not Identified any material Lfjncertainlies relating to events or conditions that, Individually or collectivety, may cast significant doubl on the charitable company's ability to continue as a going concern for a period of at least ￿e1ve months from when the financial statements are authorised for issue. Our responsibilities and the ￿spOnSibl1111es of the trustees with respect lo going concern are described in the relevant sections of this ￿POrt. Other Infomation The other information comprises Ihe information included in the annual report. other than the financial ststemenls and our auditor's report Ihereon. The trustees afe responsible for the other information contained within the annual feport Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon. Our responsibility is to read the other infomation and, in doing so. consider whether the other information is matenally inconsistent with the financial statements, or our knowledge obtained In the course of the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misslalemenls, we are required to determine whether there is a material misslalement in the financial statements themselves. If, based on the work we have performed, we conclude that there is a material misslalemenl of this other information, we are required to report that fact. 26

We have nothing to report in this regard. Opinlons on other matters prescribed by the Companles Act 2006 In our opinion, based on the work undertaken in the course of the audit the inf0m￿tion given in the trustees. annual report for the finantyal year for which the financial statements are prepared is consislenl with the financial statements., and the trustees. annual report has been prepared in accordance with applicable legal requirements. Matters on which we are requlred to report by exceptlon In the light of the knowledge and understanding of the company and ils environment obtained in the course of the audit, we have not idenbfied material misstatements in the Iruslees, annual report. We have nothing lo report in respect of the following matters where the Companies Act 2006 requ1￿$ U5 to report to you If. In our opinion" adequate accounting records have not been kept. or relums adequate for our audit have not been received from branches not visited by us.. Of the financial statements are nol in agreement with the accounting records and returns.. Of certain disclosures of trustees, remuneration specified by law are not made., lorl we have not received all the information and explanaliofts we require for our audit. l orl the Iruslees were not enlilled to prepar8 the financial statements In accordance with the small companies, regime and tske advantage of the small companies exemption in preparing the Iruslees. annual report and from Pfeparing a strategic report. Re8ponslbllitles of tni8tge8 As explained more fully In the trustees, responsibilities statement set out on page 25. the Iruslees (who are also the directors of the charitable company for the purposes of company lawl are Tesponsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such Internal control as the IfUStee$ determine is necessary to enable the PTeparation of financial statements that are free from material misstatement, whether due lo fraud or error. In preparing the financial ststements. the trustees are responsible for assessing the charitable company'$ ability lo continue as a going cOn￿M. disclosing, as applicable. matters related lo going concern and using the going concern basis of accounting unles5 the Iruslees either intend lo liquidate the charitsble company or lo cease operations. or have no realistic allemalive bul lo do so. Auditor's Responslbilltie6 for the audlt of the finan¢i41 $tatement8 Our objectives are to obtain reasonable assurance about whelher the financial slalements as a whole are free from material misslatemenl, whether due lo fraud or error, and lo issue an auditor's report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAS IUKI will always detect a material misstatement when it exists. Misslalements can arise from fraud or error and are considered materi81 if, individually or in aggregate. they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial 5talernents. As part of an audit in accordance with ISAS IUKI we exercise prOfeSs￿nal judgement and maintain professional sceplicism throughout the audit. We are also.. Identify and assess the risks of material misstatement of the financial statements, whether due lo fraud or error. design and perform audit PTocedures responsive to those risk5, and obtain audit evidence that Is sufficient and appropriate to provide a basis for our opinion. The risk of not delecling a material misstalemenl resultsng from fraud is higher than for one resulting from 27

error, as fraud May involve colluston. forgery, intenkn.onal omissions. rnisrepresentalions, or the override of intemal control. Obtsin an understsnding of Internal control relevant to the audit in order lo design audit procedures that are appropriate in the circumstances. bul not for the purposes of expressing an opinion on the effectiveness of the charitable company's internal control. Evaluate the appropriatenes5 of accounting policies used and the reasonableness of accounting estimates and related disclosures made by the trustees. Conclude on the approprialene$s of the trustees, use of the going ¢oncem basis of accounting and. based on the audit evidence obtained, whether a material uncertainty exists related lo events or condibons that may cast significant doubl on the charitable Company's ability lo continue as a going cOn￿rn. If we conclude that a matenal uncertainty exists, we are requsred to draw attention in our auditorfs report to the related disdosures in the financial slalements or, if such disclosufes are inadequate, lo modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditorfs report. However, future events or conditions may Cause the ¢hanlable company to ¢ea$e to continue as a going concern. Evaluate the overall p￿sentatIOn. structure and content of the financial statements, including the disclosures, and whether the financial statements rep￿sent the underlying transactions and events in a manner that achieves fair presentation. We communicate with those charged with governan￿ regardin9, among other matters, the planned scope and liming of the audit and significant audit findings, including any si9nificanl deficien¢ies in internal control that we idenbfy during our audit. Explanatlon as to what extent the audlt was considered capable of dgte¢tlng Irregularltles, includlng fraud Irregularities, includin9 fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities. outlined above. to detect material misstalemenls in respect of Irregularities, including fraud. The extent to wh￿h our procedures affj capable of detecting irregularities, including fraud is detailed below. The objectives of our audit in reswcl of fraud. are lo identify and assess the risks of material misstatement of the financial slalements due lo fraud, lo obtain sufficient appropriate audit evidence regarding the assessed risks of material misslalemenl due to fraud. through designing and implementing appropriate responses lo those assessed risks." and lo respond appropriately lo Instances of fraud or suspected fraud identified dufing the audit However, the primary responsibility for Ine prevention and detection of fraud rests with both rnana9e￿nt and those charged with governance of the charitable company. Our approach was as follows.. Vve obtained an understsnding of the legal and regulatory requirements applicable to the charitable company and considered that the most significant are the Companies Act 2006, the Charities Act 2011, the Charity {FRS102} SORP, and UK financial reporting standards as issued by the Financial Reporting Council obtained an understanding of how the charitsble company complies with these requirements by discussions with management and ihose charged with governance. Vve assessed the risk of malerial misstatement of the financial slatemenls, including the risk of material misslatemenl due lo fraud and how it might occur. by holding discussions with management and those charged with governance. Vve inquired of management and Ihose charged with governance as to any known instances of non-compliance or suspected rlon-compliance with laws and regulations. 28

Based on this understanding. we designed specific appropriate audit procedures to identify InStan￿S of non-compliance with laws and regulations. This included making enquiries of management and those charged with governance and obtaining additional corroborative evidence as required. There are inherent limitations in the audit procedures described above. We are less likely to become aware of instances of non-compliance with laws and regulations that are not elosely related to events and transactions reflected in the financial stslement5. Also, the risk of not detecting a material rnisstatemenl due to fraud is higher than the risk of not detecting one resulting from error, as fraud may involve deliberate concealment by. for example. forgery or intentional misrepresentations, or through collusion. Use of our report This report is made solety to the charitable company's members, as a body, in accordance with Chapter 3 of Part 16 of the Companie5 Act 2006 Our audit work has been undertaken so that we might slate to the company's member5 those matters we are required lo stale lo them in an auditor's report and for no other purpose. To the fullest exlenl permitted by law. we do not accept or assume responsibility to any paty other than the charitable Company and chanlable company's members as a body, for our audit work, for this report, or for the opinions we have formed_ J.A LLe Date: Nell Finlayson {Senlor Statutory Auditoil for and on behalf ol Moore Kingston Smith LLP. Stalutory Auditor Devonshire House 60 Goswell Road London EC1M 7AD 29

DiabEles Research and Wellness Foundation statement of Flnan¢lal ActEv￿leS Iln¢orporatlng th¢ Summary Income and ExpendNure Account) For the year ended 31 December 2021 FuDd5 Funds Fuffjd Funds TOTAL In¢om• DDnations legac￿ 1.5X).774 119.r64 15.219 15.286 1.54S.( 119.664 15.219 1.494.22 131 303 ?4,525 l.S18.745 131 8.W4 ¢Jher Charitable Tiadiry AdMtI |n¥ygtmen15 Income Iillrn C￿lit￿tIt￿lI (Xher 1ncaffle 1.665.9)7 15.288 1.639 628 8?32 1647 1.664 143 8232 1 672.395 1.670715 13.288 i e8SC61 24.525 Exp•ndltyr• Qn.. RuL4inD FfftJ¥ ChpTltalM¢Adiwli ¢Jher 265 995 2￿.998 1.408.394 I.W.255 18.269 1￿42? l ￿.4?2 N•t InEom• 229fj47 214 36t 10251 20C6 Tr•nsf•r bth••n Funds N•t I￿¥•m•h1 ITr Funds Z29.047 1D281 Totsl Fund knu9ht for￿￿¢ Z.gB1 2 1.W1 2.991.￿1 23YI 2 715235 989 598

Diabetes Research and WelSness Foundation Balance Sheet As at 31 December 2021 Nole 2021 2021 2020 2020 Flxed Assets Tangible Assets 16 6,535 4,800 Current Assets Debtors Cash al bank and in hand 17 541.825 2,708.728 139,465 3,160,905 3.250.553 3,300.370 Credltors - Amounts falllng due within one yeai 18 1481.853} 315,574 Net Curr9nt A8sels 2.768,700 2 775 235 2.984.796 2 989 $96 Total Net Assets Reserves Restricted Fund General Reserve 23.542 2.751.693 2 775 235 8,256 2,981,340 2 989 596 These linanclal slalernents have been prepared in accordance wth the provisions applicable lo companies subject lo the sm811 cornpanies regime within Part 15 of the ¢ompani¢s Act 2￿6 and with the Financial Reporting Standard FRS 102 SORP lellective January 20151 The financial statements were approved. and authorised for distnbution. by the Trustees on and slgned on their behalf by.. gJthLLA . Trustee Michael Gretschel The accompanying notes form an integral part ol these Iinan¢ial staternents Company number.. 03496304 31

Diabetes Research and Wellness Foundation ststèmènt of Cash Flows For the year ended 31 December 2021 2021 2020 ash used in Owrating Aetivili$ 1446 4111 1104.2 Casb Flows Irom Investlng A¢tl¥iti? Intqmst on Bank fw"rt 6.101 3.225 14.016) 2,676 C¥$h Flows Ifom Finan¢ing A¢tivfti ChAnge In cash u•h qui¥Al•nt¥ lo th• yt•r {452.17n 1101.3541 Cash and Cash wuivalentl brought to￿4 1st January 3.1￿.￿5 3,262,259 C•sh and ¢sh •qulvalenlJ at Y1sl t¥K•M￿r 21 J 1F09D5

Diabetes Research and Wellness Foundation Notes to the Financial Statements For the year ended 31 December 2021 l Accounting Policies The financial statements h8ve been prepared In accordance wth the Finanu81 Reporting Standard applicable In the UK and Republic of Ireland IFRS 1021 The charts￿e Cornpany Is a benefft cornpany for the purposes of FRS 102 and therefore the Charity also prepared rts financial statements in accordance wth the Staternent of Recofflmended Practice applicable to charities prepanng thefr accounts In accordance wth the Finanaal Reports"ng Stsndard appliCa￿t In the UK and Rèpublic of Irdand (The FRS 102 Charfoes SORPI. the Companies Act 2006 and the Charitses Act 2011 The trustees have assessed whether the use ol the going concern b8BB ￿ approwatè and have considere(S p0$5ib4è ￿entS or conditions that rnight cast signffjicant doubt on the ablity of the chavty to conb.nue as a going concern. The ch8rty h88 gwen due conw¢eration for the effects of the Cowd-19 oulbreak The chanty wdl conbnue wrth a full progiamme of direct mail campaigns lo ensure continuty of its major Income strearns In the nexl finanoal year. The annual programme ol Awareness Events and Fund Raising Events wll be a comtsnaton ol online and tradth'onal events and r(15 8nb"cipéd the income stie8mB will increase in the next financial yèar. The trustees made thr& assessment for a period of at least on8 year Irorn the date ol approval ol the financial statements In pa￿cular the tsustees have cOn￿der+d the charity's forecasts and projections and have taken account Of Pressures on donabtsns Ineome Aftèr making enquiries the trustees have concluded that there Is a reasonable expeclatson that the charty has 8deque resources to cont'nue in opeiab'onal exisleDce for the lorese•able future. The charity therelore continues to adopt the going concern ba￿ in preparing ts finan¢ial stslements. The finan¢ial statements afe pr8par8d in $trfing. which is the functional eurreney of the cornpany Monetsry grn¢unts in these financ121 $tatenents are rounded Its the nearest pound. The fffianci81 ststements have been prepared on the historical cost convention, modffied to include certain financial instrumènts at la'r value. The prin¢ipal 8¢counting policie8 adopted are set out below. Crltkal ￿OUntIng estlmates and areas of judg•m•nt In the view of the tru$ie¢s In ap￿￿n9 the a¢countsng poliLies adopted. no judgements were required that have a signrficant •ffe¢l on th6 amounts rteognts•d In thè finanoal statements nor do any e8ts"mates or assumpbons rnade c8rry a signrficant rl8k of mat¢dal odju$trnent In the n¥t fin¥noal year. The pnn¢ipd accounts.ng policies ol the company are 8et out below. Incom• Incgme ts Ineluded on #n aeeiu* èxe•pt that donthon8 und•r grft aid togother wrth the assoc1ated Incom6 tsx recoverie8 are Cfedrted aB In¢ome when the donabons are r¢¢eiwJ. Mgmber$hip Subscriptsons ale apporbon¢d across the membership subscription period. Legacles Legacies are recognised followng probate and once theie is sufficent ewdence that receipt is probable and the amount of the legacy receivablè ¢an bè measured reliably Where ent(dement to a legacy exists but there IB uncert4inty as to its receipt or the amount r6ceN8t4È, detsipd are disdosed as a eonbngent asset unts"I the cTitena for income recogn￿"0n are met. Publlc Donations and Gifts4n-Klnd Incoming resources in the forrn of Grt&in-lfjnd arè inelud8d bn th8 Statement of Financial Activstses only when assets donated to the charity are dr61nbuted Grfts-in-Kind are donth.ons of eommodthès direcuy usable in charrtable programmes, such as food, blankets, book5. agricuRural and medical SUPFthes. The Chanty has an Internatronally recognised and accepted monitonng programme in place to ensure that Cornrnod￿es are appropnatdy valued at wholesale or less, ¢u￿￿rallY appropriate for the designated programme, and can be both PToperfy shipped and dthbuled grats to the de51gnated beneficiaries. Grfl Aid Repayments Income from gift aid repayment Claims is onty Induded for claims wh￿h have beèn submitted for lax periods ending on or before the year end and when the recapt ol this Income r& certain. 33

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2021 1 Accounting Polleit5 Icontinuedl Expenditure Expenditure, whi¢h is eharged gn an acc¥uab b8ws. Y8 allocated be￿en." expenditure incurred directy in the effort to raise voluntsry contributions (cost of generats'ng fund81," o expendrture In¢urred d¢rectylo the fU￿lMent olthe charW8 otyecbve8 Icharrtatrle expendrtur?)". Charrtable expènth'ture comprtses al the oxpanthture incurred by th¢ ¢harrty in meathng ts charrta￿e objectives and i further analysed beNveen. grants pay8b in tr furth¢ran¢e of th ¢harWB ¢osts of 8¢IN￿.8$ in furthèrancè ofthe ¢harty'$ obiecbves o support eosts ol the chaiity Cost Apports'onmant Where Item$ of expendrture invofve more than one eost category thè8e ¢osts have been apportioned on a reasonable basuq as determined by tt)É Iru$t¢es. One parb"¢ular area where the cost Is materi81 lo the ¢harty r8 in th8 pioduet'on and distribution of direct mailings. One of the purp08es ol the mai shot is to dèvdop a database of names of ￿1th a parb"cular interest in the activrties ol the charity and ts Charrtatle objects It ￿ hdd ¢hat Indmduab who make a £10 or greater donation, In responsè to th8 mailing. have a degree of inler8St In dKabetes They are intèrested b8caus• they suffer from diabete5, know som•bot who does or could themsefves be at n5k of developing the condrtion. These are precisdy the pèoplè whom the charity ￿ trying to help and eon$8quenty Ihey féeèNe the benefits ol ihe educaional material provided by the charty. These high Interest indNiduaL8 consbtute 25% 01 the respon8e8,' so the chaty allocates 25% of the cost ol the malling to Costs In furtherance of tht char￿$ obi¢ts. Furthermore the remoining expendrtuie has been ¢110¢8led on the bas of whether the edv¢8bonal content of the individual maling is 8ignnScanUy high enough so as to be matenal. When thL8 holds true the remaining c05t of th• tnailing 16 alloced on a pro-ra bagjs comparing the eduGatsonal content (costs In furtherdnce ol the chanty's objeclsl to the fund rawng content (costs of generab'ng fvndsl. The educationa content ra determined by the amount of t•yt and space on each mathng th to maten¥l of an educabonal n8tuFo. Tebrnarketing expendrture B allocated in a con%stent manner wrth maihngs, a5 described above. h¥n¢e thè chaity allocates 250h of the cost of the tdemarktth.ng caTrs lo costs in further8n¢e glthè th8frtVs objacts'vas. with the remaining expendrtufe allocated on the basr& of whether the tme spent during the tdephone call is in accordance llh the charty's objects or otherwise. Fund raising expendrture i.e. Text that rnay induce 8 donatrjn from the reawen¢ ts alocated uptsn the ba818 ol th volume of the text and space that ts not rdated to tèxt ol an educalonal natufe. Support ¢08ts eompm ell othar overhèad cogts for thè running ofthe charity a8 an organis8tr"on. Fund Accounting Designated funds are unrÈstncted lunds eamarked by the Trustees for particular puiposes. The aim and use of each fund is set out in the notes to the financial statements. Unrestricted funds are donats.ons and other incoming resources receNed or generated for expendrture on the general objeckn.ves ofthe ehènty. Restncted funds 8re donabon8 receNed frorn a th)nor who has specified a parbcular are8 of the charilY$ work to which the donab.on should be allocated. 34

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2021 Accounting Policies Icontinuedl Grants Payable Grants are recognised when they become due for payment. Included ￿￿thIn the Slalemenl of Financial Activities is the cost of grant instalments that are payable to charitable organisations I Individuals in accordance with the charity's governing Instruments, together with any grants payable for the year. but not paid by the year end date. The value of grants awarded which are subject to the completion ol a luture yearfs performance 15 disclosed as a Financial C¢mmitment In Note 18. Tangible Flxed Assets and Depreciation Depreciation Is calculated lo write down the cost less estimated re￿dUat value of all tangible fixed assets held lor charity use by equal annual instalments over their eycted useful economic Itve& The rates generally applicable are.. Office equipment, rixlures and frttings &7 years straght lir5e All tangible fixed assets c05ting more than £250 are capita115ed al their cost to the charrty. Forlgn Currenclè• Transactions In foreign currencies are translated at the exchange rale ru1in9 al the date of the transaction. Monetary assets and Iiabililie5 in foreign Currencies are translaied al the rates ol exchange ruling al the balance sheet dale All exchange differences are dealt wth through the slatemenl of financial artivilies Leasing Commitment$ Rentals payable under operating le8ses are charged against income on a strauht line ba's over the lease term. Other Flnancial Instruments l. Cash and cash •qulv•l•nts Cash and cash equivalents Indude cash at banks and In hand and shon term depostts wrth a maturity date of three months or les6. 11. Debtors and Cr•ditors Debtois and creditors reeeivable or paYa￿e wthin one year of the reporting date are carried al their al transaction price. Debtor5 and creditors that are receivable or payable in more than one year and not subject lo a market rate of Interest are measured al the wesenl value of the expecied future receipts or payment discounted al a market rale ol interest.

Diabetes Research and Wellness Foundation Notes to the Financial Statements Icontinuedl For the year ended 31 December 2021 Donotlons and Legacies 2021 2020 Donations Lottery Piogrèrnrne LegaGie$ Rereived 654.919 760,750 8,185 749,810 1.518,745 882.536 1.546.CEO Included in the aix)ve are rsstricted donatic￿￿ of£15.28612020. £24.5251 Charltable Actlvfitles 2021 2020 Gran18 REC￿ Gift Aid Re¢eipts 22,721 108,582 131.3J3 99,116 119.664 4 Other Charlt•bl• Tradlng Acllvltl•s 2021 2020 Membership Subs¢riptl¢n8 Evenl Fees and Spuns¢r$hip 10.223 4,996 15,219 6,216 1.788 3 oth•r Incom• 2021 2020 Mi8cellan¢¢us Incom• 8.232 8.232 4.868 Fund R•lglnq Cts8tS 2021 2020 Cauing Carrws Cornpuler Charges Lettershop and Oata Pcslage and ShippirvJ Printiry Publ*rty Marketing C¢$t5 M811 Pack Premlurn Lottèry Costs Staff Costs Isee Note 121 Sweepslike Wlnnw• 139.103 125.046 1,535 3,038 3,179 16,510 1,654 2,331 7.602 14.995 7,175 6S.431 I4.￿￿) 265.996 5.489 10.183 34.346 2.288 7.539 15.491 70,353 13,411 311,127 Cttarltabl• A¢tlvttl•s 2021 Dlrtti Expe￿IllUr• (Note 101 2021 Gran¢$ Awards (Note 81 2021 Glfts KSnd INote 91 2021 Supptsrt Costs (Note 111 2021 Total ResE¥rch Into the Rdief of Diabetes Ra55ing Publ￿ Awareness Of Diabetes 3n.177 415.457 787.634 801.661 1.589.295 801.661 801.661 372.177 415.457 2020 Dlrect Expondffture INote 101 2020 Grants Awards INote 81 2020 Glfts in Klnd INote91 2020 Support Co$1$ INote111 2020 Total Research Into the Relief of Dk?beies R2L%ing pu￿1¢ Avmreness of Diabetes 289.471 407.605 697,076 711,318 1.408,394 711.318 711.318 289.471 407.605 36

Diabetes Research and Wellness Foundation Noles to the Financial Staternents {Continuedl For the year ended 31 December 2021 Oranl Awards 2021 2020 Uni¥ersty cf QAford Unt¥er8ty tsf Exetar IkYWtxMty ￿rY￿.8 LorKknI- cl1￿1 FamrA￿h1p 2018 GArdiN UnNerwty- Non ClinK•l FdKx¥•hip 2021 Atswciation wur la Recherthe wr Lè tlibete Dlab¢tes WellnesB NelwThkCafiada 122.3e6 64.978 64,978 103,351 e4,978 17001 50,415 18.(YX) abete8 R88ear¢h Instrtute FtyJndatbJn- UnNer8ty of Miami Unwelsty ol BrMtd- 2020 Pump Prthng AvArd Uniwèriily ol CarnbrWgÈ- 2020 Puy)p Prfmirrtj Ard Unwei8rty ol sir8lh¢lyde- 2020 Pump Pnmir¥ Awwd Uni¥eisrty ol Exeter- 2020 Pump Pnmw¥J A*Yrd Unwernily of tXJndee- 2020 Pump A%rd Unlveriily of Exthr. 2020 FlJmp Awwd 20.OJD 19,928 20.Q)O 19.893 19,800 Uniwrsily ef Exeter- 2021 Pump Prim¥yJ Alwd unI￿rI1%¥ ef Exeter- 2ty21 ￿rnP Awwd Unlvtrsity ol Oxlord- 2021 Purnp Prwnty AYhrd Unlvernity tsl Rothm￿On- 2021 F￿mP Pnrnmg A%wd NetUngh¥m Trent UrnveNty. 2021 Pump Pnming Awar ￿•￿•t￿ UnN•rnty- 2￿1 Pump Primlw Awwd t9.999 20,(X)J 20.C 19.7eo 19,982 372,938 336,127 L*￿.. U￿￿ll￿d ￿nts¥th b¥4[ 17611 146,656) 372 177 289 471 37

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2021 9 Gift$4n.Kind The fcllowing donation5 made dumg the year were ¢L*rned as Grfl>l￿1tind and are valued n accordaKe with cwrent market condrtions prevailing when the 9ft w85 made. Number of Shlpments Glfts-In- Kind value Shipping Costs 2021 Total 2020 Total 10 Dlrect CharItal￿¢ Expendlture 2021 2020 Staff Costs Is•e Note 121 Postage 378,118 163,383 87,870 15,183 119,918 8,241 819 28,129 801 661 373,572 141.033 42.629 13,247 107,114 10,962 1,165 21,598 Publicity Mail Pack PT¢miums Carriers Grant Costs Lettershop and Data 11 Support Costs 2021 2020 Other Staff Costs Professional Costs Management Charge Office Expens Estab115hment Expen Bank Charges and Iniar•st Paid Foreign Exchange IL¢ssl Oepreciation Irrecoverable VAT Amount5 paid to Auditors Company Secretanal Fees Other Overhe8d Costs 2,051 29,685 141,810 84,748 43,881 3.444 3,998 2,281 65.877 15.022 350 22.330 415457 5.643 22.012 141.483 82,792 44,278 3,298 5,175 1,675 70,801 17,644 350 12.454 407 605 Support Costs are alkcated to the Charrtablè expendrture ofthe chwty n proporb.on to the thre¢t ¢ost of trt 8etiwty 12 Wagès and Salarle• 2021 2020 VV8ges and Salaries Social S?Gurrty Costs Pension Costs 404.366 31.241 12.864 448.471 398,678 31.138 12.187 442,003 The key rnana9ement persomel of the charrty are Ihe Tntslee5 and the CEO. The totsl amount paid for key management personnel was £70.33912020." £66,941). 2021 2020 No. The number of higher paid ernployees was I) the band-. £60.000- £70,000 Penson contributions payable for Ihe above Indiw¢Jual was £2.72212020 £2.5921. The average nurnbe¥ of lull-bme equNaknt em￿oYeeS during the year was 12.512020.. 11.51. 38

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2021 13 Paymen15 to Tiust•e$ Ne trustee or p2rèon wrth a famity ty buwrs8 coMe¢lKfi h ètrym¢ee. recMvJ r•munw8iion ￿r. direct LY Indirect￿, from the tharty. Trustee ExpEnses lar Tr1 and CcdBre £nfl12020. £ry1) ofthtr12020. £nill ￿ NmbJr¥ed dir￿￿ta n 12020. nil) Tru¥iee8. 14 Surplus of In¢om• o¥r Expenditur• 2Q20 The exwdiurt sstaed aft•r chargirvj.. Authlor•' ReMunerotM￿'. . Audit Fee rehting to the Rna￿81 Y•w . In re¥rrtl ol ncn a￿1￿ o￿TIlln9 L••60 rents1$ ant 8 Machln•ry - Other Asaets 15,9)J 15.250 1.965 3,Cé1 3.12e 26,C￿l 5,175 1,675 Feren E￿￿•￿E LMS Dew•¢ialion IS Taxaiion eomF•ny. • rqgkntere¥ WAè cry•tkn l•x in r•y¢l of rt• oFerkn fN >wr. 16 T•TrJlbl• FSxed A¥i•ls lor Ch•rity Ui• oriice equlprnent, Ilxlure$ and Colt At 1 J•nuary 2021 Addl￿OnI In Yvr DIip08al6 in Year At 31 Decomber 2021 30,989 4.01e 35.C DeprecSation At 1 January 2021 Provided in tho y￿r Ellminaied on Th"•p( At 31 December 2021 26.188 2.281 NÈt B¢)ok Valu At 31 De¢ember 2021 At 31 O¢cemtw 21r20 17 Debtors 2021 202D Trade Debtors OtheF Debtors Prepayrnents Ac¢nd Irrto 25.013 510,812 541 825 130.354 139465 JI DebtC5 except prepèyments are financ￿ r6tNments and are measured at 5ettleft*rt ¥a￿e

OHbetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2021 10 Crnditors.. Amounts tsllin4 du• 2021 2020 rf8dÈ CreditOTS Grants Payable Isee tekwl Accruals and tkfwred Income Tax ar￿ &cial (xher cre¢rttyts 71.3gJ 33S236 616 12.577 ?D5.741 50.929 481 853 IrKiuded ￿￿tkIn other uetsil¢rn Kèwnw¢rnddtyd£n4 rJ)X¥ £DII Comrtrn•nl8411 J•rtuary 2021 GrJN$ Piyabkl lor YeJT i¥$ p¥A•61 Gr•NA pa￿ YeoT 2th,741 372.177 241.682 ?89.471 393 514 In to •mryJnti rrfrtld TtrelrLrn dr•t•ffi W•WJbl•Catothe reriwni c•nain c(wldilW TP• of Ifil• r2 19 D•r•r•d InEom• Eleired In¢llffle WFWD l•t XQI to Inwmo in Year Inrom¥ OBlerr¢d In ¥•4r Eyferfed Inctsm• CIFwfi 31•1 2D21 11.0401 5972 Cwerred In¢om• ¢OMDfige• . Event Rellir8110n lln¢ Exhibrtion Fe￿ recefvtd tIKTh70• - Reilricled Grirt8 R•¢•fftd thD1w￿ ￿ te hAwepEfb> 20 R•s•N•S M•ln expMd1￿r• lJv•rnnt 31 •t•mts•r 2021 O•n•nl R•s•m In R￿rIdI￿ F¥rrfJ IW•ling to Y4E¥urEh Resiri¢lB¢ FuDd ièlating to Ih• W Gw• thFiM•¥cf•w4• Rextriclud Funa relating to 014t4l£BWuntts D•v ￿tyrt￿r< Oèèignated Fund General ftebwve 14.78J 22.012 I50￿ 2.831 YO ISOOCQ 1.￿.42? 229.647 Bl•ne• It INtom• In Y4 xp•no￿f• In Ymr N•1 Movom•nt In Y•4r DK•rnb•t R•s•r¥• I 2020 Y•Nv Ré•irKthd Fund toOpDbetN ReslTrtrted Funa ieiatiTrg ID Tne 811 GfftChDltma$ CMI Resinctea iewing t02020 P￿p PnrThng Awarrt ¢n3tld Grthrth Fund 8.2S8 15. 8,2 11J,2Sg1 1so.om 2.83%.340 2.YJl 1.858.121 t6u.381 2021 A Lwuet c1£5fL) mrth io rn•fitthÈ OuFinp 2021 the charty partiTrytÈd In 2022 ￿rts Thelvnds ￿CeNe￿ In lh￿Ye•r w8&£14.7￿12020 £8.356J Net AsEe16 bv Unfe￿¢ted Reslrirtsd Total Tanaibie Assets CuttentAssets CuThent LiabillL￿5 6.￿5 3.227.011 481,8 2 751 693 6.5J5 5.2￿.553 481.853 2.775.235 23.Y2 23.542

Diabetes Research and Wellness Foundation Notes to Ihe Financial Statements (Continued) For the year ended 31 December 2021 21 Paymentsto Connecw ¢nnected ¢hailty Relaiionshlp NI￿re olTi•nu¢tlons Tot•1 Totsi Balanceat transactions the end trans￿￿)n5 thÈyvr •nd Intht yui Diobg19s R&S￿l¢h and WÈlln FoundgliDn Inc. 141.463 Managemènt ch8rgèE In relalw)n lolh sh3Tiry of artkles and slaff. Thm granl rnAde 10 a&siai wlh th fundlng ofihè Associal￿n.6 wMrenes5 knd duc￿lo￿al As5ociolion Fthr lè iech8rGhB diobele Oi4bot•• Welln¢ss Nefvth CAnAdA Thffd Otani mode loass4sl in Ihfj lundlng of Iha Nofvwo￿'£ set UP CLTSts. IA il roluDd olan ￿[P9yn￿rt1. N•tur of R•l•tlonships 1 DIAbetes AfjsEarch and Wdln•M FoundalioTr I￿. •• vath nu ￿. John ￿ah￿ul0sjfj 0Trlh• 80ord or Trustèès of lh• as$tsdAt•d chwbtylr¢lh• uM¢d Stgt•• 2 AsGo¢istlon poui la i•¢hei¢hsur k thAbBifr iscom￿￿e￿W￿￿l•4nd ktrW.M Gr•iq¢hBI. J.AJrLhouioJ end MT J. Hafabsitonlho BoAfd d T1￿#1405C4th@ sw¢￿E•d chbftr ITr Frdru. 3 Trabel¢• Netriork CHn•&4 1• i￿￿r￿•T￿￿h no Ivjl MtWMGiocM And J AIHhovzo¥alio•il B¢•fd ofTIus19gEoflh¢ in CBMd• Furfh•rdFi•lh iqgArdlng Ih• WI•￿￿4Pc•1 &•1￿￿￿1￿1ho Rryon. 22 pin•n¢l•l CornmJtment• Th¢ chiiw firtanciwl ¢ommhmvnl4 01£675,48412020.' £4a82rn out1￿￿￿d fjwtyWur•for t￿Ye￿ endthy 31 D4¢•mb•r 2021, Al they ir•iuW to the iempith fu￿1111￿ ¢ondrfknA. FWI• Ar• as I￿k￿. 2021 2020 329.241 94.054 84.977 PoypW• in 2022 Pay#￿8 if 2D23 Pay•W• in 2024 248.e67 221.995 105.222 23 Op•rAtlng Les•$ At 3151 Detomber 2021. lh• ¢h4rty h•Jcunrnitm•rns￿nd0r 2021 2020 2D20 Vffthtii to Fmry W￿h1￿ on• Yo•1 10 F￿￿ Y￿rn Lnd #rtd &ildingJ 28.CO] 22.107 2,464 D74 Tot1 Durlmg 2018>Arih• cholty ¢￿1¢•4￿d Fl•eredThlelo nwrfpronmses. The new lea￿ ¢omrnpnud on OEtobtrr 2018 wrfh a t•rrn ofsix ￿arS al a renl of£28,r#xi.25p pw •hnum. The leose incknd&s a break tho toiwmingie 4nw Ihree>ars The leose prov￿¥fUr two d￿r￿￿$ Df 10 r￿￿thS •xhdunng vthKh Ihe reTrl ieduG•l try gJ%. 24 fteconciliAtlon of Net Movwn•nt In Funds lo Net Cash Flowfrom operating 2021 202D Net MDvemenl in Funds- SuiFlU([W￿IlI Add b3Gk [lepreciat￿Tr Charge DEduct Inteiesl Income shrmn in In¥estinoknl DEciease Illlciease} In Dpblors Inciease {DeGits5e) in creditorya Nei Cash used Opèraling ActriiiiéA 1214.3611 2,281 12501 (402.360} 186.279 448411 12.005} 1.675 50,218 148.017 MeM￿r. Llaknlity Thè FoundpliDn a company ￿v￿￿rat￿È8. up.the {S) 12tr20-• IrJlxlrfy tslined 10£1 41