2020-12-31-accounts

Diabetes Research and Wellness Foundation IA Company Llmlted by Guaranteel Charlty Number: 1070607 Company Number: 03496304 Flnanclal Statements For the year ended 31-Dec-20

Diabetes Research and Wellness Foundation INDEX Page Report of the Trustees 1to22 Independent Auditors. Report 23to26 Stalement of Financial Activities 27 Balance Sheet 28 Stalement of Cash Flows 29 Notes to the Financial Statement8 30to38

Diabetes Research WeLLness Foundation Diabetes Research and Wellness Foundation (DRWF) (A Company ￿rnited by Guarantee) REPORT & FINANCIAL STATEMENTS For the year ended 31 December 2020 Register￿ Chanty Number 1070W7 C￿mpanY Number O3496XJ4 ,1 Cameron Mvir. Lwth)n- Edintrmirgh tyde ride. ￿jguSt 2020 THANK YOUI To everyone who donated or undertook a challenge all over the UK, during the most difficult of times. Your support has helped to safeguard our awareness, educational programmes and research funding activities. THANK YOUI for being part of a powerful community who are intent on investing in a brighter fvture for all people wilh diabetes.

Wellne55 FOundat￿n Message from our Co-Founder & Chaimian- Michael Gretschel Our focus for 2020 was on building resilience and sustainability for the future through succession planning, diversification of income streams and delivery of purposeful programs that continue to meet the ever- changing naeds of. and make a dtffereno to, people living with diabetes. To that end, Dr Shivani Misra. Consu￿ant in Metabolic Medicine & Diabetes at Imperial Colleg8 London, was elected to the Board of Trustees in January. Shivani brings a wealth of clinical and scientffic knowledge to the Board having been recognised as one of London's leading health influencers in the Evening Standard's annual Progress 1000 list in 2018. We have known Shivani for many years as shè was awarded a DRWF Fellowship in 2012 and went on to conduct the national My Diabetes Study, Vve are really pleased to have hef join th8 DR WF family. We had planned to grow and develop many of our activitEs in 2020 but of COUTse the Covid-19 pandemic brought the world pretty muth lo a standstill, wrth our daily lives &gnrficantly impacted. It has been a Challenging time for everyone but our small DRWF team really dug deep and were magnifiGent in coping with the change of working arrangements. and cancellation ol activib'es and events which ultimately resulted In several team members being furloughed. We're very lucky to have been able to bring these team members back to their full roles. when mary charities have not been so blessed. The health and safety ol our team has been paramount dunng the pandemic months and we are extremely fortunate to have arrived at this point wrthout having encountered any significant Illness duè to Covi&19. Our hearts go out to all those that have lost family and friends. Much has been learned during these difficult months and we've identÉfied a number of areas in our structure and activities which require investment of funds, time and expertise. 11 is often quoted that 'nec8881ty is the mother of invention, and we certainly discovered this to be the truth in 2020, b&in9 pushed perhaps more quickly than we might have been comfortable with, into exploring online and digital activities in greater depth. Our learnings Irom the pandemic have played a big part in helping us scope out our next 3-year growth strategy, but we are bènefitting from having a stable and well-run chafty with Ihe reserves that enable us to invest in future sustainability. whilst being responsive lo the needs of the people Ihat we 5UPPOrt and the researchers that we fund. Most importantly, we leamed that in the world'5 hour of need, me(li¢81 research pushed all boundarie5 and fcund a vaccine for Covid-19 that is now being rolled-out with lightening-speed to protect our Communrties. Diabetes is one of the wortd's leading heallh challenges- we must act with the same determination in our research for a CUREI As we continue to navigate these uncertain times, I want to thank the DRWF team, trustees, advlsory board members, supportefs and volunteers who work so Ilfelessly and give so generously to our cause. We could not achieve what we do wthout you all. Thank youl Mike Gretschel April 2021 TRUSTEES ANNUAL REPORT 2020

D14bvlKR5￿tth tp Ilne55 Foyndadon Report of the trustees for the year ended 31st December 2020 The trustees are pleased to present their report arKI message from the Chairman together wrth audlted financial statements for the year ended 31" December 2020. The financial statements comply wtth the Charitses Act 2011.. the Companies Act 2006,. the Memorandum and Articles of Association and are prepared in accordance with the Financial Reporting Stsndard applicable in the UK and Republic of Ireland (FRS 102 Charities SORP) (effective from 1" January 2015). Our purpose, aims and activities The objeds of the charity are: To assist in the relief of persons with diabet88 and any similar or related diseases or conditions To raise public aWa￿nesS about diabetes and any similar or related diseases or conditions, Ih8ir incidence, causes, treatment, avoKlance and relief The focus of our work There are more than 4 million people diagnosed with diabetes in the UK. This figure has morethan doubled n the last 20 years and K is anticipated that If nothing changes, this will rise to 5 mllllon in the next 4 years. Afound 90¥0 of people with diabetes have type 2, which can often be p￿Vented. There a￿ a numb8r of risk factors which increas8 the likelihood of a type 2 diagnosis. such as being overweight or obese, which puts people at greater risk of a range of chronic heaEth condibons and ultimately increased risk of premature death. Approximately 10QA of people with diabetes have type 1 diabetes which is 8 Chronic autoimmune condition where the btsjy Is unable to produce insulin which is required to regulate blood sugar levels. Type 1 diabetes cannot be prevented. It 15 estimated that up to 5Yo of those diagnosed wtth diabeles hav8 ra￿ types such as MODY (maturity onset diabetes in th8 young). CFRD (cystic fibrosis related diabeles), LADA (latent autoimmune diabetes in adults) and a small handful of other types. It is estimated th the care and treatment of diabetes ¢osts the NHS around 1 00/0 of its annual spend, which equates to approximately £10 billion per year. This is a staggering £1.1 million per hour. Whi15t all diabeles can lead to significant hea￿h thallenges, such as increased risk of cardiovascu18r disease, blindness and amputation, it is important to remember that type 2 diabetes can be prevented or at least its onset delayed. There is also evidence of people wrth type 2 diabetes achiewng 'remission' where they have had major weight loss Ihrough restriclive or bariatnc surgery Self-rnanagement of diabetes is central to reducing the risks associated wilh complicat'ons and therefo much of our work is focused on providing infonnation and educational support programmes that empower self_management and seek tc encourage a pro-active approach to good sew-care. We consider that those with the greatest knowledge of their condrtion will have a belter understanding of the disease and will be better equipped to have an Impact on the progression of th￿r diabetes and any associated complications. Our Diabetes Wellness activities in tha community provide a greal plaffomi for meeting people sharing similar health concerns, making new friends and building peer support ￿tWorkS. all of which serve to enhance both the physical and psychosoaal management of diabetes. The research we fund spans all types of diabetes and related health, helping improve understanding of cause. treatment and management wth our ultimate goal being to find a cure for what is considered to be one of the 21°, century's leading health challenges. worldwde. Wth the commitment of a mults'_disciplinary TRUSTEES ANNUAL REPORT 2020

Ros¥èrth Weiinoss FouThY4DoD Research Advisory Board, and a rigorous peer review process for applications. we invest in innovative Pump Priming projects and Fellowships which we believe will demonstrate impact for people with diabetes in the fastest time-frame. To-dat8. we have committed almost £13 million to research since our first awards were made in 1999. Demonstrating public baneflt The trustees confirm that they have referred to the 98neral guidance set out by Charty Commission on public benefrt. The trustees are satisfied that the Charty's aclivrties meet the principles of public benefit, defined as providing an idèntifiable benefitls to the public, 01 section of the public. and know of no delrirnent or harm that may be caused as a ￿sUIt of these activities, which are clearly sel out throughtrut this report. Volunteers As a small team delivering numerous actfvlties. we rety on tha support of volunteers who, participate by helping out with administrative lasks in our office.. delivering diabetes aWar￿eSS and infomialion materials., undertake user involvement exercises to help steer and develop our pr¢gramme activities., support our educational events and communty fundraising pro9ramme or sit on one of our expert panels for research or infomiation review. The number of volunteers fluctuates each year bLrt is Grucial to helping us spread the word about the work we do and to support local and national communty fundraising initiatives. We had hoped to grow our valunteer nehvork through a higher level of community adivity in 2020, however the pandemic prevented us from doing so. We hope to be able to resume community activity as soon as Covid- 19 allows and plan to build on the number of volunteers who support the charity as soon as possible, In the meantime, we wholeheartedly thank all of our volunteers for theii time, expertise and commitment to our work which helps us raise awarenessto the charity, maximise income and maintain high standards of work. Measurfng Impact We use qualitative and quantitstive approaches to monitor and evaluate our activities in order to ensure that they remain true to purpose and that the outcomes aimed for are achieved. Stakeholdeis and beneficiaries are involved in Ihese evaluation processes to ensure the continued relevance, quality, accessibility and effectiveness of activities. We also undertake independent evaluation with specialist partners fcr specific projects where expert input is required. Activities & Achievements in 2020 Awarene88, Informatlon & support Direct mail played a key part in our communications strategy during 2020, SLJPPOrting our desire to slay connected wfth key audiences who do not routlnely engage with online channels. We dislribuled 257,187 campaign packs in 2020. The health information contained wthin èach campaign is targeted at beneficiaries who could act on the Infomiation. erther in a preventative way (type 2 diabetes) or to inform and support those INing with diabetes (all lypesl, in Iheir self-management of the condilion. With a positive response from around 14'/D of those mailed. we know that al least 38,425 people across the country read the infonnation contained within the campaigns. We know from experience that il is likely Ihat many more opgned and read the informakn.on bul chose not to make direct contact wbth us at that time. Historically, we have seen numbers of people respond to communications that have been dislributed many months, or even years before, as they have held onto the information provided for future reference. Health Unlocked Forum: Our awareness messages are reaching wider audiences than ever before supported by our increased provision of news and articles on our website and social media channels and via our Health Unlocked communty forum, the woTld'5 largest social network for health. The DRWF Diabetes HU forum has a total 5785 all lime members and this has grown by 30C/ID since early 2019. Around 100/0 of all members are very active in posting and joining discussions. This is enabling us to interact with more dwerse communities where the risk andlor impact of diabetes can be TRUSTEES ANNUAL REPORT 2020

r*abETE5 Re5eaKh cUne55 FDuThYJt higher and where people feel that they have a safe SP￿ within which to share their experiences. gain support and make a difference to others too. It was clear from the outsel of the pandemiG that our ability to reach those that wè support through digital channels was going to be crucial to our continued operations. To that end, we had to adapt quickly to enga9e with supporters and benefi￿arleS alike with lockdown measures accelerating our use of digital channels. This was essenlial in order to stay connected with the diabetes community during a time of considerable stres5. when people with diabetes were being told that they were at greater risk of significanl illness if they contracted coronavirus. We doubled our efforts lo generate regular reliabl8 news items, and self-management articles to support people through improved understanding of 'sick day rules,. In 2019 our website received 190.174 unique page views. In 2020 that rose lo 372,045 uniqué page views. This is an increase in websrte traffic of over 95'A. At the start of the pandemic. when it became apparent that we would have to cancel our community events for the foreseeable future, we ran a social media campaign to promote our series of diabetes information leaflets to ensure that P60ple were sign-posted to reliable, Information Standard a¢credited, adult health and social Care infomation. In 2019 there were 10,653 downloads of these leaflets. In 2020 this leapt to 37,416 which is a thre&fold increase. ilst in 2019 we had started to explore podcast content as a means of engaging and supporting diabetes healthcare professionals and people living with diabetes, we Increased our efforts through this channel in 2020 as an alternative to written information and video Contenl. This resulted in double the number of visitors to our podcasts about Lrfe with Diabetes seeing 549 downloads, a small but solid start to delivering infomiation in this format. In 2020 we increased our efforts to ralse awareness of our actiwtlas and servlces to more peoplè through social media campaigns with most engagement being seen through our Facebook page. In 2019 our sponsor&J content reached an average of 7.597 people a day, roughly 2,773,000 people in total. In 2020 our sponsored content re8¢h more than doubled lo an average of 20,399 people a day, around 7,445,635 people in tolal and well over 10°A of the total UK population. This plafform enables us to engage in conversation with a diverse audien￿. often answering general diabetes related self-managemenl queries," addressing confusions about diabetes, and increasingly ￿SpOnding to questions and commen15 aboul diabetes research and re￿￿t advances. Our p8tient infomiation resources are available fw of charge. As stsndafd, they can be requested in hard copy or downloaded from our website as pdf or audio files,. requested In enlarged print format or allernative. There was a significanl reduction in requests for physical information in the period. This is possibly because people were otherwise caught up in the pandemic. Additionally, because we had minimal staff onsite we were encouraging people to go lo our website to download information in pdf and audio format,. to listen to our podcast series for additional help and lo interact wth our social media channels. The Impact of this contributes to the increased traffic to our websrte during the period whi¢h saw a 3-fold increase in the volume of resources downloaded. We distributed 117,177 copies of our newsletter. Diabetes Wellness News, to subscribers. healthcare professionals and regular givers. This is 2 10h decrease in the circulation numbers of 2019. The newslelter is distributed lo annual subscnbers, and on a complimentary basis to heallhcare providers who share the infrjrmation with their patient communitRs. On a quartedy ba515 the circulation Is b¢)osted as we focus on the research element of our work and send a copy to our regular givers. It is difficult to accurately predict the true readership of the newsletter but through anecdotal evidence. it is clear that il is much wider than those who have specifically requgsted to rec8ive it. The number of healthcare professionals on Our database increased by 60/0 during the year and this was largely due to sjgn up of HCPS at Diabetes Professional Care held at the end of 2019. Health & care infomiation you can trust TRUSTEES ANNUAL REPORT 2020

WeunÈ55 FDuTr¢atyun Our Diabetes Awareness Necklace is distributed free of charge to people with diabetes and heatthcare professionals for onward distribution. These necklaces provide emergency identffication for those with diabetes should they b8 unable to alert the emergency services to their conclition. They carry the wording '1 have diabetes, please test my blood before treating me.. They are distrib(Jted along wrth medical check-up cards that ar8 used to record tests and results to infomi self-management stralagies. We responded to 1457 specific requests for free neCkla￿S during the year, a reduction of 490h in the period. This was direcuy impacted by the pandemic, a shift in focus for everyone al that time ar)d our abilty to respond to fuffilment with staff on furlough and working remotely from home I￿4VE My husbandhas recently b68n rfiagnosed ¥￿h Type 2 diabgt8s and suffers from Card￿Vas¢U1ar d￿aSe. which mgans he couldpotentially collapse anfvMè, anytina. We Lx)th think Ihat your awa￿neSS necklace could pmve Invaluable. We want to say what 8 fanta8tK you provide- the Quallty In Care Diabetes- award winnlng Diabetes Wellnes8 educational events Diabetes structured education airns to provide people with diabetes with the knowledge and confidence to selfThmanage a long-tem condilion effectively. The offer of structured education across the country has improved over more recent years. However, the rates of attendance are still very low and vary widely. Self-management 1$ Genlral lo diabeles care. Yet, it is ￿ported that high numbers of people with diab&tes experience 8mollonal or psychological probF8ms, such as dePre￿On, anxiety and diabetes distress, all of which can impact the ability and motivation to self-manage effectivoly. This leads lo poorer health outcomes, reduced quality of life and increased healthcare costs. Being able to access appropriate support 15 integral lo good self-management. Qic INN£• We have been running an annual progr8mme of Diabetes Wellness events since 2001. We work with diabetes, and related healthcare professionals to facilitate workshops that provide rdevant, up-t(>date. 8vidence-based informab'on covering all aspects of diabetes and related haalth. Delegates choose the sessions and talks that they attend meaning that they create their own agenda for th8 day. improving engagement and supporting better outcomes. These events bring together a wealth of information, expertise and peer support under one roof. The event programme is devised and delivered by experts and offer5 rolating workshops that focus on the day-to-day management of diabetes and the prevention and management of associated complications. An exhibi￿.On hall provides a central hub where delegate5 can access a range of support from primary, secondary and community organisations. -Leaming about di8betes at thes8 events is contribuling significantly towards my improved ha81th and wellbeing. We know thal managing diabetes is challenging and effeciive coping strategies are crucial lo support optimal health. These coping strategies are important not just to people living With diabetes but their family, friends and carers. Peer support plays an important part in emollonal wellbeing and this in turn can have an obvious Impacl on the ability to self-manage effectively. For this ￿aSon. we feel it is important to include family. friends and carers in workshops and discussions which facilitates discussion around managing diabetes. perception5 and expectations, in an environment where everyone has experienced or is expenencing something similar. These events are relaxed and welcoming in approach. They are inclusive and provide for diverse needs. Thèy also provide an amazing opportunity to SFknd time with a whole host of health care professionals asking the questions that really rnatter to the individual, in a relaxed and informal environment. TRUSTEES ANNUAL REPORT 2020

(habew Research Diabetes Wellness Days in 2020 There were 3 Wellness Days scheduled to take pla￿ in 2020, all of which had to be cancelled due to the coronavirus pandemic. Venue terms and conditions were negotiated to minimize any cost to the charity due to cancellation. All venues were very considerate in their approach and allowed for rescheduling of dates with deferment of deposits and cancellation charges where applicable. The cancellation of these events redU￿d related workload and so the DRWF event co-ordinator role was furloughed be￿een 181 May and 30th September. supported through the Government's Coronavirus Job Retention Scheme. We produced an interactive digital toolkit incorporating top tips and self-management articles with links to podcast and video content for beneficiaries who had registered to attend the Wellness events. This at least went some way to ensuring that we had provided access to the suppcrtive conlenl that participants would have benefitted from had they been able to attend an event in person. Diabetes Professior,al Care-DPC Dlabetes Professlonal Care & Unlted Through Dlabet88 We have supported Diabetes Professional Care {DPC) in the provision ofan educational event for diabetes and related health care professionals for the past 5 years. Usually this CPD accredited event accommodates 5000+ attendees, over a 2-day period at Olympia in London. DPC was unable to proceed with the usual format of event due to the pandemic. Working with an online media agency, they were able to pivot quickly offering online educational workshops to HCP'S throughout the pandemic months which culminated in a large online activity in the lead-up to World Diabetes Day. This gave "Just Ilke to say • hug• DRWF an opportunity to relain visibility wrthin the HCP THANK YOU for a fabulously community, contributing to Ihe programme of talks and Infom7atlve and useful day. workshops, as well as providing a plattorm for engaging Well organlsed, wlth t8lks fmm those who have the Interested parties in discussion about the charity's aclivities. knowledgo." In partnership with DPC, we co-hosted an additional patient educational event entitled United thmugh Diabetes on World Diabetes Day. This helped us to deliver a purposeful event at scale on a digital platform that we otherwise could not have offered to the diabetes community. There were over 4000 pre-registrations for UTD from diabetes healthcare professionals. public health officials and people living with diabetes from around the world. On November 141h 1340 people logged-on to the virtual platform and participaled in 21 workshops, talks, panel discussions and community forum sessions, supported by 35 diabetes and related health experts Ihfoughoul the day. People participated from 41 countries with 91 % of attendee5 from the UK. "It was •n awesome event, full of upto-date r81evant Inforn?atlon necessary for both the healthcare practltlonws and the patlents wlth dlabetes. I want to say very many thanks to you all forglvlng me the opportunity of galnlng more skills and knowledge about diabetes." Dlgital Consullation Research We were asked to support Dr Charles Fox and Dr Anne Kilvert, Northampton Diabetes Service, who were conducting a national survey lo understand how people with diabetes were having their ongoing healthcare consultations during the pandemic ie. In person. telephone or video consultation. This was to ascertain the approach and outCJ)me for both healthcare professional TRUSTEES ANNUAL REPORT 2020

V4eiir*s5 FoundatrtsTr and patient. To that end. we utilised the carrier sheet wtih the December distribution of Diabetes Wellness News to secure participants. We had a 3.40/0 response rate, securing opinions from 312 of 9328 DWN subscribers. This was supplemented by social media calls pointing to an online version of the survey lo increase representation. The outcome of this study will be published in Practical Diabetes in 2021. Diabetes Wellness Family Camp There are around 29,000 children and young people in the UK liwng wth Type1 Diabetes. For these young people, quality of lrfe can be adversely affecteyear Clinical and Non-clinical Fellowship and 1-year Pump Priming project awards. Institutional and discretionary awards are available when funds allow. Contract funding of key personnel within the DRWF Human Islet Isolation Facilty at the Churchill Hospital. Oxford is subject to proposal and review on a mulkn-year rollin9 contract basis. We are a member of Ihe Association of Medical Research Charities {AMRCI. Membership is the hallmark of quality research funding. As members. we support the use of s rigorous peer review procedure In the allocats'on of our research funding. Our Research Advisory Board IRABI is a multi-disciplinary panel of expert clinicians and scientists who assess applications for funding. AMRC carry out audit on research procedures every five years in order to check that they meet the expected gold slandard. Universities, amrc TRUSTEES ANNUAL REPORT 2020

Dièbeies Rèseèrth Et W4ikne55 Founda￿On govemment and other funding bodies recognise AMRC membership as an indicator of quality. It also qualifies our grant funding for support from the govemment's Charity Research Support Fund which enables universities to increase the funds we award by around 20Q/D. We also benefit from the AMRC training and development programme which supports continued use of besi practice processes and procedures. It was clear very early on following lockdown on 23td March, that research in progress and research funding would be adversely affected by the pandemic. AMRC liaised with its charity members from the outset to establish the impact that Covid-19 would have on charity income". ability to continu8 funding existing awards, and the impact on new funding calls. They reported an anticipated 41 Vo downturn in research funding over the next year. a predicted £310 million shortfall in support of life-saving discovenes. The DRIfvF 2020 Non-clinical Fellowship award that had been called in late 2019 was deferred until November 2020; a 5-month delay to our usual review and allocation schedule. This was largely due to the unavailability of clinicianslscientists who perform peer reV￿W on applications received, where they had been redeployed or furloughed due to Covid-19. This delay had a knock-on effect to the call for applications for the 2021 Pump Priming awards being announced. This usually takes place in August for award by 31 December. However, on this occasion the call was announced in November for award in Q2 2021. The d&fennent of our grants round during the year reduced associated workload and il seemed prudent al that time to fudough our Research Grants Administrator between 1° May and 30th October. This role was supported through the Government's Coronavirus Job Retention schem•. We liaised with all Current funding recipients to understand the environment within which they were working. to establish whether there was pause or delay to th•r work which would necessitate a 'no-cost extension, request. Thi5 was the case with a number of awards, wrth a total of 10 researchers being offered exlenslons inlo 2021. The financial impact of this is a reduction in funds paid to researchèrs in 2020 with increased expenditure ￿flected in the 2021 budget. CAIIDIFF 2020 Professor Davld Matthews Non-CllnlGal Fellowshlp 23 pre•applications were received, resuiting in 13 fv11 application8 bwng submrtted. Three candidates were invited lo interview which was carried out by video call. The Research Advisory Board mel on 2" December and subsequently recommend8d that the 3-year Fellowship be offered to Slephanie Hanna, Cardlff Unlverslty £194,933. Funding was approved by the Board of Trustees on 16th December. UNIVERSITY PRI IYSCOL . CAE￿Dy￿7 Stephanie's work- "Immunotherapy in typ8 1 diabeles aims to reduce tlie bodys Immune attack on the insulin-producing beta cells. To develop Ihese Ireatmenfs, it is important to be able to and monrtor the white blo￿ cells Ihat cause Ihe damage. We cannot stuty these ￿lIS safely in Ihe pancrèas and numbers in the blood atE very low. However, I have observed that after injecting molecules derived from the be18 Ge115 into the skin. I can delect white blocKI cells multiplying in skin. I have also been able to detect Ils multiplying in lymph glands that draln the skin using ultrasound guided needle sampling. These are likely to be cells from the pancreas attracted to the skin by the injeclion ofpancr&as derived prolein. I will study these ￿lIS using state-of-the-art single ￿11 analysis technology and use this infomation to d8V8Iop highly targeted treatments for the immune ￿SpOnSe in typ& 1 diabetes.. Pump Priming 2021 (call announced November 2020 to be awarded in early 20211 A total of 27 applicab.ons were received for Consideration. These wll be reviewed by the Research Advisory Board in Q12021. TRUSTEES ANNUAL REPORT 2020

.) D*bo1è5 R¢seir(h Ep WthessFaunthtl¢Jn Islet Cell Research & Transplant DR WF has made a considerable contribution to the funding of islet cell research and transplant in the UK and around the wodd. Thè DRWF Human Islet Isolation Facility at Chur¢hill Hospilal. Oxford plays a pivotal role in providing islels for research and transplant as part of a national treatment prografflme. the clinical element of which Is funded by the NHS. Three personnel are fvnded within the facility (around 30% of facility staffj: Lab Manager- due for review Jan 2021 Deputy Lab Manager (post doc researcher)- Funding proposal received Feb 2020 Islet Transplant Administrator- Funding proposal re￿iVed Feb 2020 New funding proposals were received in February for the Deputy Lab Manager and Islet Transplant Administrator positions, as Current awards terminated on 30 April. 2020. Having reviewed the proposals. the Board considered that it would be Prudent to off8r continued funding for 1 year only. giving us the opportunity to establish how Covid-19 would impact our income over Ihe course of the year. This resulted In new awards being offergj for 1 yearfrom 14 May 2020- 30° April 2021. Subsequently, due to Covld-19, the Islet Transplant Administrator position was furloughed and later becarne vacant. The DepLrty Lab Manager position also became vacant with no-cost extensions being agreed by the Board for both positions. Impact report from the Dlrector of the DRWF Islet Isolatlon Facillty Churchill Hospltal, Oxford by Professor Paul Johnson ()xi-,0121) The last 12 months has been a challenging time for everyone involved in healthcare worfdwKle. Many routlne treatments in our hospitals have been 8uspended as our cllnical services have been protected to ensure sufficient capacity for the large number of COVID admission5. In addition, the considerable risk of stsrting patients on powerful immunosuppression in a COVID envrronment has meant that many transplant services have been severely restricted. In Oxford, most of our transplant services were suspenaed for a large part of the pandemic. The UK 151et Transplant Programme remained open for a small nurnber of priority patients only who were requinng 'top-up' grafts. These patients were chosen as they had an urgent cllnical need and had already been established on immunosuppressian. The Oxft)rd DRWF Human Islet Isolation Facilily therefore remained open throughout the pandemic to provide islets for these patients and the staff remained 'on call, throughout. Pancreas donation was initially significantly reduced due to ICU restrictions and difficutties proving thai donors were definitely COVID-free. However, once these issuas had been addressed, organ donation activrty for clinical use was re-establish&J. However, research pancreayes remained very limited. We continue to process pancreases from a broad donor pool. Impresswely, our isolation outcomes ontinue to match the leading isolation centres World-wide for this range of donors. In 2018, ￿enty-foUr out of 53 pancreases processed resulted in an islet yield of >200.000 IEQ whereas in 2019 this was twenty- two out of 43. Pre-COVID we also continued to isolate and distribute research islets lo scientists across the UK, wth 19 islet preparations distributed to a wide range of research groups throughout the UK in 2018 and 16 in 2019. Our provision of high-quality human dinical Islets has Impacted direcuy on patients with type 1 diabetes locally and throughout the UK. with transfomied by diabetes stabilisation and reversal. The distribution of research islets has enabled a wide-range of drfferent diabetes research projects lo be undertaken resulting in many high-impact publications. The generous funding from DR has been essential for these achievements. During the pandemic, the University closed many of ts research facilities for various periods of time. This has limited our research activity, but the team has continued to be research active whenever this has been possible. We continue lo undertake novel research into the development of physiolog ical islet scaffold5 and islet macro-capsules. design of a novel islet culture. and optr"misation of islet oxygenation including proteomic characterisation during i51et isolation. We were a key partner in a Horizon 20120 European Grant and continue to be cenlral to hvo themes Isurgical & L)iabetes) of the Oxford Biomedical Research Centre. io TRUSTEES ANNUAL REPORT 2020

_.? TrabeiEsftesttrth ly Wellnes5 Founthbon The Oxford DRWF Isolation team have Continued to be highly recognised in the islet transplant and islet research fields. Professor Paul Johnson has continued lo Chair the NHSBT UK Islet Transplant Steering Group throughout thi5 drfficult time. This has involved close liaising with the NHS and difficult decisions about keeping islet transplant recipients safe. He has continued to giv8 Invited lectures to learned societies, albeit increasingly in a virtual fomat. Team members have continued lo present at international scientif meetings, including the last ePITA (European Pancreas and Islet Transplant Association) conference held in Austria in January 2020. We continue to publish our Work regularly in peer-reviewed joumals wrth appropriate DRWF acknowledgem8nL Looking ahead to the next 12 months. we have already started to see the return of normal islet isolation activity and have started to reactivate our islel transplant reciptent list. We have just started an exciting new initiative with NHSBT called 'lncreasing the Number of organs Available for Research. IINOARI- Thi5 important project will enable donor organs from donors with diabètes to now be retrieved roulinely from acras5 the UK for research purposes. Up until now. this ha5 been very sporadic and there has b￿n no infraslrudure for research relrievals. The Oxford DRWF Islet Isolation Facility will lead an 'lslel Plafform, wrth responsibility for Isolating and distributing islets for ￿Search from these rare pancreases. This will be a unique resource for researchers as they iry io find a cure for diabetes. Again, the 'lslet Platfomi, has only been made possible as a resull of DRWF'S long-term partnership with th8 Oxford Facility. All the Oxford Isolation team remain extremety grateful to DR WF for their partnership wtth Oxford. We look forward to Maintaining and further developing this partnership and c¢lIaL￿ratIon for many y&ars to come. How we raised our money In 2020 Our approach to fundraislng - The Trustees are aware of their individual responsibility and accountability lo ensu￿ that the Gharity fundraises legally, responsibly and effectively. Our focus for 2020 was on building re$ll￿nCe and sustainability for the future through succession planning, diversification of income streams and delivary of purposeful programs Ihat continue to meet the ever<h8nging needs of people with diabetes. The largest volume fundraising activity that the chanty has is a direct mail programme. Legacy income and regular giving programmes are also sources of higher volumelvalue donations to the charity at this point and we seek to develop Communty and digital fundraising activilEs so that they make a more meaningful contribution to the charity's public engagemenl and income generation. Additionally, we make applications to appropriate trusts and foundations. Historically, we hav6 relied heavily on income from Direct Mail and Regular Giving programmes to $ustain our voluntary income. These programmes continue and do very well for us. but in order lo ensure that we are competitive and responsive lo our supporter needs, current and new, we must ensure that we offer engagement choice and an experience that hel￿ maximise recruitment opportunities and capitalises on retention and loyalty. By Febwary 2020, Covid-19 had gathered pace around the world and it became apparent very quickly that we needed lo consider our future working arrangements and business continuity plans in respect of - Possible impact on current and future activrties and operations of the charty Implication for Ihe charity's finances and fundraising Effect on financial sustainability and going concem Consideration of the charitys reserves. their nature and adequacy Effect on future aims and activities A significant challenge given the scale and unpredictsbilty of the issue. The initial impact of Cowd was felt by the DRVVF team who were required to work remotely from 23 March when the UK entered national lockdown. Fortunately. we had been able to address the necessary technology and equipment requirements to enable us to work from home by 20 Mard). However. the uncertainty and ev&r-changing TRUSTEES ANNUAL FIEPORT 2020

Dtsbeces Resèètch & Ine5s FoJndBtton landscape made it almost impossible to set out a response plan that provided a stable working structure for any length of time, with frequent need to reassess and change dir&lion. Our Direct Mail programme was affected in the early months of COVKI with a number of campaigns being dropped andlor delayed in the schedule. We had hoped to step up prospecting in 2020 and whilst a couple of tests were condL¢Cted, we didn't manage to carry out the level of acquisition that we'd projected for the year. The overall volume of DM campaigns dislributed in 2020 was around 35.10 less than in 2019 with an over311 redudion of income of 24 /0 in this activity- ilst there were no changes to main Sery1￿ providers in the period, our Direct Mail pfogramme response handlers experienced issues very eady on meaning that they offered restricted services between March and July. This meant that we had to be readive and put in pla￿ temporary processes to enable continuation of campaign responses from our offices. requiring two staff to work on-site to manage incoming mail, open batch and bank donatr'ons etc. Whilst the volume of mail that we were able to process through a manual procèss was limited, rt meanl that we were helping to minimise the backlog of mail building up, limit impact on cash-flow and enabl8 real-time infomiation to be updated on our CRM so as to avoid future impact on our appeals and campaigns. Fortunatèly. thi5 51tuation was resolved by July and all campaign returns were cleared through the month. We had expected to see an increase in regular giving cancellations during th9 year h¢)weveT, whilst it appeared that this might be the case early on in the pandemic, our attrrtion over the year was actually consistenl with 2019 at 7%. Legacy income. which is difficult to accurately predict, increased ￿eYOnd expectats'on in th8 year. We received notification of numerous bequests, some of which were quite high value and which deposited funds very quickly. Legacy income was around 69 /4 h￿hor than we had ant￿Ipated during the year, around £300,000+ up on budget. We had planned to scale up our communty fundraising activities in early 2020 by hiring a regional community fundraiser in the Midlands, however this plan had to be put on hold. Our full programme of charity organised community fundraising activrties was cancelled between 23 March and 31" December, reducing projected Income from this stream by around 70°A. However. there were som8 am82ing supporters who despite the significant personal and professional challenges thal Covid-19 placed on all of us. continued to raise funds in aid of DRWF knowing that il was a real struggle for all Charities and really wanting to show their support and make a drfFerence We are indebted to these supporters. The Head of Community Fundraising was furtoughed belween 1° May arnl 30 June to give us time to understand the redudion in workload and redu￿ assorjated costs to the charty. This role was supported through the Government's Coronavirus Job Retenlion Scheme. We retumed this role lo employment through a phased return as we were able to increase fundraising activities, lafgely through digilal fundraising campaigns. Whi15t a number of grant applications were made during the year, none retumed a posrtNe response. Many funders were rethinking their granl parameters to fo¢us on Cowd-19 relat&d programmes. We considered howlwhere we might be able to positicn ourselves to provide a meaningful diabetes and Covid-19 specific support programmo that would provide benefrt In the diabetes community and support an applic8*'on for grant funding, but found this very difficult to shape. Consequently, our attempts lo secure funds through Grants and Trusts were unsuccessful in the year. We secured grant income through the Government's CoronaMru5 Job Retention Scheme in support of three staff positions that were furloughed over a period of 6 months (see financsal review section for detail). Corporate Partnerships We do not endorse products, but we will support initiatives that increase awafeness to DRVVF and our activities, and where there is an appropriate message, product or service for people wilh diabetes. To this 12 TRUSTEES ANNUAL REPORT 2020

Dwbqt•5 ￿5￿r(h FJ Wellness FounoaDon end, we have worked to explore meaningful partnership and corporate sponsorship opportunities, where there is a synergy in mission. vision and values. Any potential partnership is assessed for feasibilrf£y, compatibility with our own objectives, and risk to ensure there is no detrimental effect to our reputstion or fundraising potential. Robust risk assessment supports our desire to only engage in suitable and best velue partnerships. Detailed discussion and negotiation ensures that both parties aims ar8 complementary and mutually beneficial. This ensures transparency and integrity in all partnerships. We did not Work wrf(h a prolessional fundraiser during the year. Commercial participation agreements are in place where necessary. Income by Source In 2020 •Grants • Dc4UtK Leycie5 • Gift Ald • ot￿r We can't do this without our amazing supportersl During the pandemic months of 2020, much ofour planned communrty fundraising activity was cancelled. We relied more than ever on commrtted supporters coming up with novel fundraising ideas, within the parameters of lockdown reslrictions, to generate awareness and financial support for our ongoing operations. Cameron's London-Edlnburyh Cycle London-based carne￿n Muir marked 20 years of Ilving with type 1 diabeles by cycling from London to Edinburgh with a group of friends, in aid of DR WF. Cameron w&s joined by 8 group of close friends for the fundraising challenge covering more than 400 miles. They sei off frixn Dalston. London on 28th August and mada it ntyth of the bonder to reach Edinbuoh on 4th September. The group of friends came up wilh the idea during a lockdown stroll. Cameron and friend James wanted to do something worthwhile with Iheirtime lo give s(xnelhing back, as the wortd ￿turned to nomlality after the firsl Covid-19 lockdown. 13 TRUSTEES ANNUAL REPORT 2020

Dl4bprs Rs*aich e55 Cameron said. I was diagnosed with lype I diabet@s aged 10 in 2010. My family and I were away orp an annual trip wth a group of lamily fv'ends when I became very ill and had to be rushed to hospital. 11 was a shock to fi.nd out that I had diabetic ketoacthsis. I had to remain in hospital for a week until the doctors coulcl stabilise my condition. It is now my 20th year of taking insulin and I have had many ups and downs with controlling my blood Sugar along the way. 'My gr8ndmother, Dr Nonna Cooper. who was one of my biggesl supporters being a doctor hersem, very sadly d￿d in April She was very interested in ftsea￿￿ for a cur8 for diabetes and used to gwe money to the rese8rch centre in Aberdeen in the hopes that she would see a cure during h8r lifelime. 'There'll be a cur8 soon,, she used to writ8 lo me, sending me many newspaper cut-outs 8nd any inf0mlat￿n that she coukl get her hands on. In my grandmotheffs memory I decided, 8long with my girtfrEnd and four of my friends, lo raise money for Diabeles Research & Wellness Foundation, Cycling fmm my home in London k) my p8r8nt s hth￿e in Edinburgh. This is 500 n7iles whrh we hope to ach￿Ve in one week. Di•besesRciCaTI- °My difficulties as a child growing up with diabetes and as a léena9er ieally affect8d my Ilfe. Al school I was a keen sportwan. and al university I became the caplain of the 1st XV rugby team. It was hard for me to get my sugar18vels rwht bel￿ and aftermalches. Now l am so gfaleful lorthe technology that h8S been developed. I wear a sensor on my leg so that I so that I can tsst myblood sugar with my sm8rtphone, and il recorcls everything for me. I would like lo raise money in order lo help find the cure that my grdndmother was hq)Ing forand to help more young peopl8 like me who have been diagnosed at an early Cameron and his friends raised Just almost £17,OCh) in 8UPPOrt of our Pump Priming awards. These are 1 year cllnlcallnon-cllnlcal 'proof of Con￿Pt. projects which aim to Collect translational pilot study data the resutts of which often enable the researchers lo ￿verage larger, higher value multi-year grant funding to expand their work. In Memory of Rose Edith hlills- 1> January 1929- Prf Alay 2020 Rose died in May 2020 at Ihe age of 91. Sh8 had Suffe￿ from diabetes for many years and r8gularfy supported DRWF. as well as several other charities. Rose is greatly missed by many people as a loving Mum. Nanny, Grnat Nanny arpd Friend. She liked nothing better Ihan bein9 Wlth her family as il gfPW year byye8r. Having livedin the same house foroverseventyyears, Rose was known by all her neighbours as the lady who helped out ￿th a listening ear, who took in parcels and in h61ryoungeryoars, helped out eldeily neighbours. Rose s son Andrew set up a tnbule page inviting famity and friends to share m&mor￿S and makg a donation to DRWF raising over £500. These are just tsvo examples of the cixnmitted dt)nors and supporters of our ¢harity who take on countless sporling events and challenges,. make regular donations or galvanise their local communities into raising funds to support our work. We can't thank them enDughl 14 TRUStEES ANNUAL REPORT 2020

Dlabvle5 Aese3r(h Weliffless Iound*lD Fundraising Regvlator. We a￿ a levy-paying member ofthe Fundraising Regulator and subscribe to the associated fundraising codes of practice. The charity suppresses individual supporter reGords against the Mail1r￿ Preference Service, Telephone preferen￿ SONI￿ and the Fundraising Preference SeNice, which helps to ensure that we do not approach individuals who have expressly requested that we do not contact them. During the year, we were notified of 26 FPS requests. which are suppressed from all contact, 100 less than received in 2019. Complalnts: The charty has a published complaints procedure, available on ts website. and endeavours lo respond to enquiries and complaints within the ststed timeframe. Most contacts tend to be a request to opt-out of charity communications by existing supporters and we monitor the basis on which people request this i.e. content of appeal, volume of contsct", type of contact,. method of conts¢t to inform our campaign5 Wlth the aim of reducing any perception of unreasonabl8 intrusion, persistent approach or undue pressure to support. We didn'l receive any complaints aboLrt our bJndraising practices during the year. GDPR and Data Protectlon: We are committed to protecting the p8r8onal informab'on and privacy of individuals that we engage with and comply with relevaTrt18gislation and codes of practlce. whilst carrying out our essential work of raising awareness of diabetes. providing information and support, and raising funds. Our privacy poliw, published al dTrvf.org.uk sets out how we capture. process, manag8 and retsin p8rsonal inforniats'on. en the Covid-19 pandemlc required the DRWF team to move lo home working, addrtlonal measures were PLrt in place to ensure that we remained GDPR compliant Our IT providers set up VPNIGOTOMYPC licences to safeguard access to DRWF files and data.. post was managed by staff wor￿￿ on sitè until our reslricllons allowed mor8 of the team to relum to the office. Financial Review Principal income streams in the year were dire¢X mail caMpa￿nS,. regular giving via direct debit,. legacy income and gift aid assouated with voluntary donations. During the pandemic, we adopted a short-term reaclive, medium term pro-active and long-term Strategic approach to manage the many challenges that we encountered 8cross the year. Income and expenditure was monilored on a weekly basis with budgetslforecasts adjusted accordingly. Total income was£1,872,385. This was a decrease of5.10/0 on budgeted income but an increase of 10.7°/0 on Income received in 2019. Voluntary donab'ons including gift aid receipts ai £1.650.048 was up by 11.60/9 on 2019. Legacy income, having budgeted for very cautiously on notes of intent only, Yias £749,810, up by 77.3°A on budgeted income, and £432,006 (73.6%> more than received in 2019. Total expendrture in the year at £1.674.390 was 18.6% below budget and a decrease of 15.4°h on èxpenditure in 2019. At year-end, we were showing a deficit of £2.005. This was £293.016 less than the deficit we had anticipaled at £295,021, a budget that had been set before the Covid-19 pandemi¢. A revised forecast to take account of the Covid-19 situation forecast a deficit of £169.096 for the year. Dlrect charitable expenditu￿ was 84p in every £1 sp￿t {85p in 2019- a decrease of 1.20kn) Governmenl Grants The charity made use of the Coronavirus Job Retention Scheme offered by Government during the Covid- 19 pandemic. Several employees were furtoughed betW88n May and October 2020. The accruals mathod was used for the government grant and accounted for under FRS 102 Sectian 24 "Govemment Grants,. Income received totalled £22.721 in the year. 15 TRUSTEES ANNUAL REPORT 2020

.) Diabeies Respirth & Wel￿￿$￿ Founthtion Investment Policy Under the Memorandum arKI Artides of Ass¢xiation. the charity has the p)wer to invest in any way the trustees see fit. The trusteés, in order to minimise to risk and having regard to the liquidity rèquirements of the charity, and to Ihe reserves policy, have historically operated a policy of keeping available funds in a higher interest bearing deposit account seeking to achieve a rate of deposrt interest which matches or exceeds inflalion as measured by the retail prices index. The trustees have regularly reV￿wed opportunities to increase investment retum from short-term. easy acces5. Options bearing in mind the desire to ensure that we can reaGt quickly to appropriate requests for additional research support as they arise. The trustees are also conscious of on%oing cash-flow requirements during a challenging lime where historical fundraising methods are raising less income and where new methods of fundraising are being tested at higher cost. All things considered, the trustees believe it appropriate to continue to explore investmènt opportunities as they present themselves. With a view io maximising return on ils deposits. Reserves Pollcy To safeguard the need for suificlent funds lo cover ongoing management, adminlstration and support costs, as well as respond lo further grant requests that might arise. the Board aims to maintain unr&slricted, free reserves at a level that equals 3-6 months of operating and charitable expenditures, which equates lo be￿een £539,907 and £1,079,814. During financial year 2020, lolal expenditure was £1.674.390 Allowing for adjustrnents and forward research commitments, the charity's expenditures for financial year 2021 are likely to be in the region of £2,159,628. At 316C December 2020. the charity held free reserves {unrestricted reserves less designated funcling, less fixed assets) of £2,981.340. This is the equlvalent of approximately 16.6 months operatsng and charitable expenditures. The trustees are committed lo strengthening exislin9 income Streams whilst diversifying fundraising activities lo redu￿ reliance on single sources. 11 is expected that this will lake investment in testing of activities where the accuracy of predicting response rates. in terms of volume and value of gift, will be more challenging and take time to inform our wider grovrth strategy. The pandemic has shown us the need to have a broad range of activities and has highlighted the need for investment in technology, expertise and resour¢e. Funds have been designated for this purpose. Currant resery8s, whilst in eX￿s5 of those anticipated, will enable us to establish the medium-long tem impact of the pandemie on fundraising ath"vitie5 and navigate these more challenging times whilst exploring ways in which to dIVer￿fy income generation and develop the charty's objective activities for future sustainabilrty. Golng concern The trustees consider that there are no matenal uncertainlies about the charrty's ability to continue as a going con￿M. The trustees have made this a55e5sment for a period of al least one year from the date of the approval of these financial slatements having giv8n consideralion to known commitments, forecasts and projections and possible pressures on income generats"on. After making these considerations. the trustees conclude that there is a reasonable expectation that the Gharitable company has adequate resouros to continue in operational existence for the foreseeable future. The charitable company therefore continues to adopt the going con￿rn basis in preparing the financial slatements. 16 TRUSTEES ANNUAL REPORT 2020

CWèbotP5 RpseaKh LY Our focus in 2021 and beyond Much has been learned durir¥J the drfficull months of the pandemic and we have identified a number of vulnerabilities in our structure and activities. Investment is required in technology, expertise and resources and this will be addressed through designated funding which h35 been set aside to support our 3-year Growth Strategy (2021-24). In doing so, we wll be better posrtioned lo weather future disruption thèreby building resilien￿ and sustainability. We continue to closely monitor- Impact on Current and fulure actlvftles and operatlon ol the charity, Its flnances and fundraising Communication has been key throughout the pandemic months and Ihe health and safety of the DRVVF team has been paramount. Providing reassurance through clear communication at regular intervals was fiJndarnental to ensuring that we continued io work cohesively, whilst understanding that the crisis was having an immediale and sustained effecl on people's lives beyond the workplace. To this end, we ran employee surveys between April and December 2020 focused on health and wellbeing to identify anxiety. stress and fatigue helping us to establish thè need for additional support. We furloughed 3 staff during the year. all of whom are now back to full contractual working arrangements. Team members a￿ still working from home and we are currently conducting an impact assessment to understand the feeling around returning lo usual working practices if, as is currentty advised, Govid-related restrictions are lifted entirely from 21° June, 2021. We ar& fortunate to have arrNed at this point without having encounter•J any significant illness in our team and we are very grateful for thal. Ongoing communication through muttiple channels is helping us to establish how the public willlar8 Starting to re-engage with communrty activities and this wlll be vitally important to sleer our approach to digital and in-person campaigns and events. to ensure that we maximise opportunity and continue lo meet the needs ol our benefiaaries and stakeholders. Growth Strategy Through the work of our Core Fundraising Group we have identified numerous ways in which to refine and develop existing fundraising activities to enable us to streryjihen and diversify Income streams. 2020 has shown us the need to be agile, integrated and adaptive in our appraach. Whilst the past year has been incredibly challenging. we have been resourceful where possible and gained invaluable experien￿ that will help us reconfigure our approach to'what good looks like, for DRVVF our supporters and beneficianes. To this end. we have scoped out a 3-year grovrth strategy which clearly defines our vision. mission and values and the diTection that we will lake to build a robust organisation that is welkpositioned for the future. The strategy defines our key adivilies to maximise opportunity in - Dlabetes Wellness Nefviork (volunteer and community fvndraising activity) Diabetes Wellness Programme (our core programme activities in support of people with diabetes) Research Funding (redefine our research strategy to maximise opportunity for collaboration with likepminded partners) Designated funding has been allocated to support the growth strategy in 2021. 17 TRLISTEES ANNUAL REPORT 2020

j Diabp*5 & WEilness Fountsanon Reference and Administrative Details Charity Number-. 107ffi07 Company number. 03496304 Registered Office.. Building 6000 Langstone Technology Park Havant. Hampshire P09 1SA Tel.. [phone] Website.. dr￿.0rg.uk Trustees & Directors.. Mr W. Michael Gretschel (Chairman) Mr John Alahcuzo$ Mr Jeffrey Harab Mrs Valerie Hussey Mr Steve Jones {elected October 2019) Dr Shivani Misra (elected January 2020) Mrs Sarah Tutton (Bone) Chief Executive.. Adviser8 Bankers.. Barclays Bank PIC 1 Churchill Place London E14 5HP Solidtors.. Blake Morgan LLP New Kings Court Tollgate Chandlers Ford Eastleigh S053 3LG Secretary: 81ake Morgan Company Secretary Services Moore Kingston Smiih LLP Devonshire House 60 Goswell Road London EC1M 7AD Auditors: 18 TRUSTEES ANNUAL REPORT 2020

Ihbes Re￿r(￿ & WeNnes5 PoutthDoTr Structure, Governance & Management Governlng Document - The Diabet8s Research and Wellness Foundation. also known as DRWF, is a registered charitable company (Registered Charity No 1070607 and Company No 03496304) 1￿MIted by guarantee and governed by rts Memorandum and Artide5 of Assoctation dated 15 January 1998 and amended by specAal resolutions passed on 15" June 1998. 2nd Detsmber 2001 and 24th April 2005. Recrultment & Appointment of Trnstees - The charty trustees are also the directors of the company for the purposes of company law. As dlctated by the charity's Arb'cles of Association, directors are appointed by the Company Members. Any person desiring to be admitted to the membership of the company is required to apply in writing. No person shall be admitted until approved by resolution passed in atrxjrdance with the Articles of Association by the existing members, who hold absolute discretion a510 the admission of any person. The Trustees of the charity. being mindful that th8 board should offer a diversity of skills to fulfil statulory and fiduciary duties, are open to recommendations for new board members. The business and medicavhealth related skills within the existing board member pool are supported by personal experience of diabetes. which assists the board in ensuring that objective activities meet beneficlary need. Additionally, the board is supported in its decision-making processes by a Research Advi50ry 8oard. which has an indepèndent Chairman. The RAB members review applications 8nd make recommgndation for r8s8arch funding awards. An Editorial Advisory Board provides 8UPPOrt to the provision of health and social care information. Both board5 are made up of clinicians, scients'sts and other 'experts' In the field of diabetes and re18ted health and strengthen the services that the charty offers its beneficiaries. All board members are subject to conflict of interest poli¢les and processes. Trustee Indu¢tion and Tralnlng Newty elected Trustees receNe an InduGtion Pack that outlines the role and responsibilities of the Trustee, along with a history of the structure and purpose of the charity. The pack Includes a copy of the governing do¢ument and contact details of all board members. There is also an outline of the Chairman of the Board's role and responsibilities along with delai15 of the executive officer taking responsibility for the daily management of the Charity. Trustees are required to comply with the eligibility requirements set out by Charty Commission and to review and update an annual 'register of interests,. Trustees are kept up to dale with various govemance publications and notlces from appropriate professional advisory memberships. Additionally, trustees might be advised of appropriat& gcvernance courses that they may benefii from attending lo ensure diversrty and conlinuty of knowledge and skills within the Board. New￿ elected trustees are invtted to attend a Review Meeting with the chair. after an agreed time lapse, in order to feedbad< their first impressions and address any COn￿M$. Trustee5 are actively encouraged to participate in the charity's outreach prcgramme of ucational evenls. Qrganisatlon The str*•gl¢ dirgction and policy of the charity is the responsibility of the Board of Trustees. During 2020 six trustees served on the Board, trom a vaiiety of professional backgrounds relevant to the work of the charity. Ordinarily. Ihe Board meets at least once each year in person and holds quarterly teleconferen￿ meetings with additional meetings organised as required. Due to the coronavirus pandemic, the Board met more frequenlly during 2020 via Zoom video meeting. There were no rneetings in-person during the year. 19 TRUSTEES ANNUAL REPORT 2020

Orbp¢es Rè5earth IT LI￿$5 FoundattQ Rlsk Management - The Trustees have examined the major strategic, business, reputational and operational risks that the charity faces. This involves identFfyin9 specific risks." assessing their likeliheod of occurrence and potential impact; detemining what steps could be taken to mthgate those risks and delegating responsibility to key staff for overseeing management of the associated controls. The risk re9isler Is reviewed annually to ensure the adequacy of internal control mechanisms. The trustees consider that the Charity has robust intemal procedures. systems and processes and beliève that risk assessmenl is embedded throughout the organisati¢Jn. The risk register was rewewed and scored in Novembar and resulting risks discussed by the Board at a meeting held on 16th De￿rnber. There were a number of risks which ranked as MEDIUM {3- 5 amber} where addrtional control measures or alternative m6lhods of working may be required and these arè being monitored and where necessary will be addresd through our future Growth Strategy The HIGH priority risk (6 - 9 redl was in relation to pandemic response planning and considerèd the most likety barner to success and requiring immediate and Sustained attention. The Board considers that the major risks facing the charty are- Fundraising and dependency on single income streams Data security including loss of data Loss of key staff Reserves policy and cash flow sensitivity Govemment policy Covld-19 rlsk assessmentlbusine8s continulty en Ihe impact of Covid-19 hit in early March. we developed a pandemlc respon5elbusiness continuity checklist that outlined key considerations tc help us manage- Health and safety of employees Critical activities Dependencies- staffing Key supplierslcontraclors Idisaster recoveryibusiness continuity plans) Communications strategy Technology requirements Activation plans This has served as an effective plan to manage thè risk and potential impact on employees, stakeholders, beneficiaries and our key actsvities. We continue to work within this risk management frarnework whilst we navigate the pandemic and recovery phase. Trustees, responslbllltles In relatlon to the financial statoments- The trustees. who are also directors of Diabetes Research and Wellness Foundati'on for the purposes of company law, are responsible for preparing the trustees, annual report and the financlal statements in accordance with applicable law and United Kingdom Accounting Standards (Untted Kingdom Generalty AC￿pted Accounting Prath'￿.) Company law requires trustees to prepare financial statements for each financial yèar that give a Irue and fair view of the state of the affairs of the charttable Company and of the outgoing resources and application of resources, including the income and expenditure, of the chantable Company for that period. In preparing the* financial statements. the trustees are required to.. select suitable accounting policies and then apply them consistently.. observe the melhods and principles in the Charities SORP- 21 TRUSTEES ANNUAL REPORT 2020

Diabgres Rp5ear1 Dated ichael Gretschel Chairman TRUSTEES ANNUAL REPORT 2020

INDEPENDENT AUDITOR'S REPORT TO THE MEMBERS OF DIAB￿E$ RESEARCH AND WELLNESS FOUNDATION Opinion We have audited the financial statements of Diabetes Research and Wellness Foundation {'Ihe company.) for the year ended 31 December 2020 which comprise the Statement of Financial AGlivitses, the Summary Incorne and Ex￿ndItUre Account, the Balance Sheet: the Cash Fk)w Staterllenl and notes to the financial statements. including a summary of significant accounting policies. The fin8nGial reporting framework that has been applied In their preparabon is applicable law and United Kingdom Accounting Standards, including FRS 102 'The Financial Reporting Standard Applicable in the UK and Republic of Ireland. (United lth'ngdom Generally Accepted Accountsng Practul. In our opinion the financial statements.. give a true and fair view of the stale of the charitable company's affairs as at 31 December 2020 and of ils Incoming resources and applicaiion of resources. including its income and expenditure. for the year then ended., have been propedy prepared in xcordance with United Kingdom Generally A¢¢ept8d Accounting Practice,. and have been prepared in accordance wrth the requirerrnts of the Companies Act 2006. B•818 lor opinion We conducted our aL￿11 in 8c¢ordanGe wlh International Standards on Auditing IUKI IISAs{UKII and applicable law. Our responsibilitie5 under those standards are further described In the Au(lilorfs Responsibilities for the audit of the financial stalenEnls section of our ffjport. INe are independent of the charitable Company in accordance with Ihe ethical requirements that are relevant to our audit of the financial slalements in the UK. including the FRC'S Ethical Standard. and we have fulfilled our olh&r ethical responsibilities in accordance wilh these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate lo provide a basis for oui Opin￿n. Con¢luslons r•lallng to golng conc•m In auditing ltte financial slatements, we have concluded that the trustees, use of the going concern basis of accounting in the Preparation of the financBI statements is appropriate. Based on the work we have performed. we have not i¢Jentified any material uncrtainlies relating to events or condition5 that. Individually or Coll￿tIvelY, may cast significant doubt on the ¢harilable company's ability to continue as a goin9 concern for a p81iod of at least hvelve months from when the financial statements are authorised for issue. Our responsibilities and the ￿POnsIbl111[e5 of the trustees wrth ￿ spect to going concem are described In the relevant sections of this reF)Ort. other Inlormatlon Tha other information comprises the informalion included in the annual report, other than the fi'nancial slalen*nts and our auditor's report thereon. The trustees ale respons1ble for the other information. Our opinion on the financial statements ¢Joes nol cover the other infomption and. except lo the exlent othèrwise èxplicitty staled in Our report, W8 do not express any fonn of a$surance conclusion thereon. In connection wrth our audit ofthe financial st3l•mènts. our reswnsibility is to read the other information and, in doing so, consider whether the other infomtsbon Is materially inconsistent with the financial statements or our knowledge obtained In the auJrt or olherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misslatements. we are required to determine whether there is a material misstatement in the financial statements or a material misstatement of the other infonnation If. based on the work we have performed, we conclude that there is a malerial mi55talement of this other Infomiation, we are required to report that fact. 23

We have nothing lo report in this regard. Opinlons on othgr matters prescrlbed by the Companies Act 2006 In our opinion, baséd on the work undertaken in the course of the audiL the information gNen in the tnjstees, annual report for the financial year for which the financial statements are prepared Is consistent wlh the financial stslemenls, and the trustees, annual report has been prepare(I n accordance applicable legal requirements. Matter8 on whlch w• ¥r• required to report by •x¢eption In the light of the knowledge and understsnding of the company and ils environrnenl obtained in the course of Ihe audit, we have not Identified material M￿StateMentS in the trustee5' annual report. W8 have nothing to report In resroci of the following matters where the Companies Acl 2DQ6 ￿qUireS US to report to you if, in our opinK)n'. adequate accounting records have not been kepL or returns adequate for our audit have not been received from branches not visited by us". or the financial statements are not in ag￿rnant with the accounting fecords and returns.. or certain disclosures of Iruslees, rernuneralion specified by law a￿ not made., lorl we have not received 811 the Infomwiion and explanations we ￿qui￿ for our audil.l orl the trustees were not entitled lo prepare the financial stalements in accordance with the small companie5 regime and tske advantage of the small companies exemption In preparing the Trustees, Annual Report and from preparing a Strategic Report Ro•pon81blliti•8 of tTUStee# As explained more fulty in the truslees. ￿sponSIbl11t1eS slalemenl sel out on page 21, the trustees (who are also the direciors of the charrtable company for the purposes of company lawl are responsible for the preparation ol the financial slalemenls and for being salisfied that they give a true and fair view, and for such internal ￿ntrol as the tnjslees determine Is necessary to enable the proparation oi financial s1818menls Ihal are free from material misslalement. whether due to fraud or error. In preparing Ihe financial sla1ery￿nts. the tnjsteeg afè responsible for asséssing th• charitable company's ability lo continue as a going c4)ncern. discthing, as applicable, matt8rs related lo going concern and using the going ¢on¢ern basis of accounting unless ihe trustees either Intend lo liquidate the charitable company or lo cease operations, or have no realistic allernalive but lo do so Auditor's Tesponslbllltles for tho ludlt of the flnanclal statements Our obj'ectives are to obtain reasonable assurance aboul whether the financial slalements as a whole are free from material misslatemenl. whether due lo fraud or effoi, and 10 155ue an auditor's report that includes our opinion Reasonable assuran¢e is a hwJh level of assurance, but is not a guarantee Ihat an audit conducted in accordance with ISK8 {UKI will always detect a material misstalementwhen il exists. Misstalemenls can arise from fraud or error and are considered material if, individually or in aggregale, they could reasonably be expected to influence the economic ée¢isions of users taken on the basis of these financial stalemenls. I rregularities, including fraud. are instances of non-compliance with laws and regulations. We design procedures in line with OUT responsibilrties, oulined above. to delect material misstatements in respect of irregularities, Including ftaud. The exlenl to which our prO￿dUreS are capable of delecb'ng irreg4jlarilies, Including fraud Is detailed below.

Explanation as to what extent the audlt wag considered capablo of dgtecting Irregularities, including fraud The objectives of our audit in respect of fraud. are.. to idenlty and assess the rlsks of material misstatement of the financial statements due to fraud." to obtain sufficient appropriate audit evidence regarding the assessed risks of matarial misstatement due to fraud, through designing and Implementing appropriate responses to those assessed ri$ks,' and to respond appropriately lo instances of fraud or suspected fraud identified during the audit. However. the primary responsibility lor the prevention and detection of fraud rests wrth both rronagemenl and those charged goverrtantx of the charitable company. Our approach was as follows". We obtained an understsnding ol the legal and regulalory requirements applicable to the Charitable company and considered that the most significant are the Companies Act 2006, Ihe Charities Act 2011, the Charity SORP, and UK financial reporting standards as issued by th6 Financial Reporting Council. We obtained an understsnding ol how the charitable company complies with these reqU1￿MentS by discussions Wrth management and Ihose charged with governance. We assessed the risk of material mi5Statemenl of the financial statements, Including the risk of matèrial fflisststemenl due lo fraud and how it might occur, ty holding discussions wrth management and those charged with governance. We inquired of management and thos• charged wrth governance as lo any known instsnces of non-compliance or susFected non<ompliance with laws and regulations. Based on this uncjerstanding. we designed specffic appropriate audit pro￿ur&S lo identify instances of non-¢ompliance with laws and regulations. This included making enquiries of managemenl and those charged with governance and obtaining addibonal cOr¥oL￿TatIve evidence as required. As part of an audit in accordance ISAS (UKI we exercise professional judgement and maintsin professional sceplicisrn throughout ihe audil. We also.. Identify and assess the risks of malenal m1ssta1e￿￿nt of the financial statements, whether du8 lo fraud or error. design and perform audit procedures responsive lo those risk5, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misslalemenl resulting from fraud is higher than for one resulb'ng from error, as traud may involve collusion. forgery, intentional omissions, misrepresentations, or the override of internal control. obtain an understanding of inlemal control relevant to the audil in order lo desgn audit procedures thal are appropr￿te In the circumstsnces. bul not for the purposes of expressing an opinion on the effectiveness of the chantable ¢ompany's inl&mal control. Evaluate the appropnateness of accounting poI￿leS used and the reasonableness of accounting estimate5 and related disclosures made by the trustees. Conclude ort the approprlatenes5 of the trustees, use of the goiw concem basis of accounting and, based on the audit eviden￿ obtained, whether a material uncertainty exists related lo events or conditions that may cast signifunt doubt on the charitable company's ability lo continue as a going concern. If we conclude that a material uncertainty exists, we are requi￿& lo draw attenb.on in our auditor's report to the related disclosures in the financial slalements or, if such disclosures are inadequate. to mc¥Jify our opinion. Our conclusions are based on the audit evidence obtained up to the dale of our auditors report. However. future events or conditions may cause the charrtable company to cease lo ￿ntinUe as a going Goncefn. 25

Evaluate the ovefall presentstion, structure and content of the finallcial statements, including the disclosures. and whether the financial statemènts represent the undertying transactions and events in a manner thal achieves fair presentation. We communicate with those charged with govemance regarding. aTr￿ng other matters, the planned s¢ope and limin9 of the audit and significant audrt findings, induding any significant deficiencies In internal control that we identsfy during our audiL Use of our report This report Is made solely to the charitable company's W￿MberS, as a body, in a¢cordanTr with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the company'$ memL*rs those matters we are required to state to them in an audrtor's report and for no olher purpose To the fullest extent permrtted by law, we do noi accept or 8ssume responsibility to any party other than the ¢haritable company and charitable company's members as a body, for our audit work, for this report, or for the opinion5 we have fonned. J.A LL Dale. .17.Jun.p 2921 Nell Flnlayson {Senlor Ststutory Audbtorl for and on behalf ol Moore Kingston Smrth LLP. Statutory Audrtor Devonshire HoLtse 60 Goswell Road London EC1M 7AD

robJo

Diabetes Research and Wellness Foundation Notes to the Financial Statements For the year ended 31 Decembei 2020 1 Accounting Policies ThÉ financx81 st8t8ments have been r)repafed in witr Ihe Financial Report"'ng Standard applicable In tP7e UK and Republi¢ of Ireland IFRS 1021. The Charitable Company is 8 puoli¢ benefi.t CO￿panY for the purposes ol FRS 102 and Ihar6ft)rè thè Charty also prepareol Its finafici￿ sratemènts in accordance with the Statement of Recommended Practice appllcable to ¢hadEies prèparing their accounis In accordance wth the Financ4al Repornng Standard applicable In the UK and Republlc of Ireland IThtr FRS 102 char￿e$ SORPI. Ihe Companies Act 2006 and ihe Chadties Aei 2011. Thè trust88s have 8&5888ed whether ihe use ol the gthng ￿¢eM basis is approFKiate and have considered possible •venls or condlions that m1gM cast signthcant doubl on tre abiltty ol the charity lo continue 85 a going concern The chaiily has givén due consioèratiDn for the eft9cts ol the CovKJ-19 OLrtbreak The chanty will continue a full programme ol direct rnail campaigns to ensure conlinuty of rts major Trneome streams In the next fiiancial ygai. Tho annu81 progr3ffltne ol Awareness Events ane Funcl Raising Evènts wll be a combinKJn of online and IradrtlDn31 events and It is ant￿cipated tho Income streams wll Inc￿aSe in tne next financlal year The Irusiees have m8de thts assessmgnt for a period of al le8St ono year from the dai• ol approval ol Ihe finanoal slalernents. In particular Me trustees havè considered Ihè charity's forg¢s$Is and projections and have taken acceunt tsf pressures on donations income Afr.er making enquir186 lh8 trust8es have concluded th81 ihere 18 a reasonable expectation tttal the ¢h8nty has adequate resources lo continue in ¢peralional existence for the foreseeable luture The charity therefore continues lo acts)Pl ¢h9 going concern basis In preparing rinanaal slatem8nl8. The fjnanc4al staremènts are pr•par8d in Sithrvj. whiL 1$ the lunclional ojrrency of the cornpany. K4onetary amounts In these financial statements are rounded to the nearest pound The flrnènoal sla:em8nis hav8 b•8n p',8pai8d on lh8 historic41 ost convention, m￿lfied io indtsd• tsrtain finanoal i￿s￿umentS al lair value Tho yln¢ipal accounbng Policies adopted afg Set out belDW Crltlcal accountlng estlrnates and ar•as ofltsdggm•nt In the view off ltr.e trustees in applying ltte accountitsg politse8 8dopied. no judgements were required thai have a significant effect on Ihe ornounl¥ recognised In the Iinanoal statements rKr do ony esty'm8les or a8sunption6 made carry 6 signiflcant risk of matèrial aejustmènt In the nexl finap.cial year. The principal a¢counting poliue5 01 the cornpany are $91 out behx. Income Income 18 included on an accru￿8 basis exc4pt thatdon8tsons under grft together ¥￿th the assoaated Income tsx recovènes are credited as Income whèn thè don"ons ¥re rewved Membership Subscripbons 8re 8ptN)rtion8d 8cross the membership Bubscriplion ￿ri04. Legacles Legacies are recognised following probate ancj once the@ Is sufficient evidence Ihai rceipt is probabl& and the amount ol Ihe18gacy receivabl8 can b• mé88ured i8li8bly. Where eniiuement io a legacy exists but tnere Is uncertainty as to Its receipt or the amount receivable. details are disdosed 35 a contingent assei up.tsl th8 Ctit&iia loi Incomè t9CQgnib"on srè mèt. Publlc Donations and Glfts-In-Klnd Incoming resources In the lom) of Gsfts-in-Kind are Included in the Slatemenl ￿ Financial Activities onty when assets donated lo phe charily ai& distribLrt8d. Grft8-1￿Klnd 8re dOn￿￿￿S ol commodrties direclly usat)le In ¢hanlable prggommes, such as IDDd, blankets. books, agricu￿Jral an¢ rn&dioxl supplies. The Chanty has an int&mation8lly recognis8d ènd accepted monitoring programme In place lo •nsui• that wtnffKxJities are appropriately ¥al￿d at wholesale or less. cullurdlly appropriate lor the eesignated PTograrnrne. and can ue both Pforrly shipped and distributed gralis to tre designated beneficiaries Gift Aid Rapaymènts Income from gift aid ￿paYment claims Is only inejuded fr)r daims wthic* have been submitted lor tax penods ending on or belgre the year en¢ and when ￿CeIpt of this income is certain. 30

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2020 1 Accounting Policies Icontinuedl Expendlturè Expenditure, which is charged crf) an accru41$ bas18. Is allocatad between: o expenditure incuThe(I difedy In the effort lo raise voluntary (xjntributions Icosi of genarating funds),. o expenditur8 in￿rTed direcly lo fulfilment of the charilYs objeclive8 (charitable expenditure).. Charitabl8 exp8ndilure comprises all the expen¢lture mcurred by tha tharily in meeting its tharitabk objectives an is further analysed between" grants payablè in the furth￿r8￿Ce of the charit¢s objectNes costs OF activities in furtherance of Ihe d)aiity'$ obiedives support costs ol Ihe charity Cost Apportionment Wher8 ittrms of 8xpendilure involve more than on¢ cost category Ihes8 costs havè been apporlioned on reasonable basls as determined by the trusi8e$ One particular a￿a Whe￿ the cost Is material lo the Gharily In the produclion and distnbLrtion ot #irect m8ilings One of tho purpoB88 of Ihg mail shot Is to d&vé1ep B database of n8mes of people wrth a p91voJlar Inlerast in th• aclSvlli8s of tho charity and ils charitablo obi•cts. 11 Is held that indvidu8ls %tho make 8 £10 or greater donation. in response to the mailing. have a degrèè of intère$t in diabei8s. They a￿ Ip.tere6ted because they suffer from di8betes, know somebody who doès or could themselvès be ai risk ol d•veloping the condjlson. Th$str are pr$¢i$$ly the peoplè whom Ihe charity is trying lo help and congequertty they receive thè bènefits of the educational material provided by Ihtr Charity. These high ini8r851 indmduals consiilute 25% 01 the total responses: so the charity Ilocates 25.10 Df the rx)sl of the mailing lo c0618 in furtheranc8 of Iho charit￿S obj8CIS. Furthermore the remaining eypendrture has been allocaied on the basi$ ol whether the eduCat￿nal content of the indlvldu81 mailin9 is signrficantly high 6nou9h so as to bc materkgl When ihis holds true ihe rem8inin9 Cost ol the m¥ilin9 is allocated on a pro-rata b8S18 comparing th8 educaiional content I￿$1$ In lurtherance ot the charrtV8 objects) lo th¥ fvnd raising content Icosls of generating funds) The edu¢alion81 content is determined by th amount of lext an(J space on each masling that Is dedicaled to material ol an educ81ional n91u￿. Telemarketing expenditure 18 allo￿te¢y in a consistent manner wilh mailings, as describ8d above. hence th8 charity allocatès 250/0 of the ¢08101 the telemarketing call3 to cosis in furtherance of tte eharily's objectives. with the remaining expenditure allocate(l on the b8sis of whelher the lime 5penl during the telephon8 call is in a¢cordance with tho ch8rity'8 otsie(3 or otherwlse. Fund raising &xpeThYilure i.e. Te￿ that may Induce a donation from th r8cipi8nl. is allocated upon the bass of the volume ol Ihe text and space that 1$ not related to text of an educational nature. Support cosis comprise all olh8t overhe￿1 costs for tho running of the charity as an organisahon. Fund Accountlng Designated funds are unreslricted knnd5 earrnarked by the Trustees for particular purwses. Thg aiffl and use of each fund Is s¢1 out in the notes lo the fin8nciHI 3tslements. Unrestricted funds are 4onations and other In￿￿ng resources received or generated ft)r expenditure on the general objecii¥es c1 the tharity. Restricted funds a￿ donalitsns received from a dO￿r who has specified a pa￿"cUlar arèa of the oharity's work lo which the donaiitsn should be allocated. 31

Diabetes Research and Wellness Foundation Notes to the Financial Ststements (Continued) For the year ended 31 December 2020 1 Accounting Policies {continued} Gran16 Payable Grants are recognised when they becorne due for payment. Included wthin the Statement of Financial Activities is the cost of grant Instalrnents that are paYats￿ lo charrtable organisations l Indiv￿gua1$ in accordance with the charity's governing instrument5, together wilh any grants payable for the year. but not paid by the year end date. The value of grants awarded which are subjecl lo the completion of a fvture yearfs performance 15 disclosed as a Financial Commitment in Not& 18. T4ngible Fixed Assets and Depreelatlon Depreciation Is calcu18ted 10 Write down the ¢cs$t less 2slim31ed residual value of all tangible fixed assets held for charity US8 by equ81 annual Instalmenls over their expected useful economic lives The rates generally applicabl8 aro.. Office gquipment. fixtures ¥nd filllngs 5-7 yèats straight line All tangiblg fixed ass8ts costing morts than £250 are capit81i8ed at Ihwr Gosl to the cherity. Forelgn Currgnclg8 Transactions in foreign currencies a￿ translated at the exchange rale nJling al ltre date of the transaction Monetary aS591s and liabililies In foreign currenries are transiqled at the fates of eychange ruling 81 th8 balance yheel dale. All exchange diflerences are dealt wilh through the slalemenl of finanual 8Ctivllleg. Leaslng Commltments Rentals payable under operating ￿aSe5 are charged against income on 8 51raight line basis over the lea$e term. Oth•r Flnan¢lal In$trum•nt• l. Cagh •nd ca•h •quival•nt8 Cash and cash equivalents include cash al banks arKf In hand 8nd Short term deposits wth a maturity dale of three months or less. il. Debtorj and CredltoryJ Debtors and creditors recgivable or paYa￿e wiihin one year of the reporti)g date are carried at their al transacllon price Debtors and creditors that are receivable or payable in mole than one year and not subjoct lo a market rale of interest are m?asur&d ai the presenl value of th• expe¢led lulure receipls or payment discounlèd Ét g market rattr ol interest.

Diabetes Research and Wellnes$ Foundation Notes to the Financial Statements {Continuedl For the year ended 31 December 2020 OOna￿onE atMI L44d•s 2020 760 759 F491 Loiwy knor4m Re¢8ived T49.81Q 317 8g4 In Ihe Hbuv¢w¢rertaed ¢Onafvo￿ t4E24.52512019 t8.OXI CttarltabiA¢uvllSb 202D 301• 22,721 GIftAJdRè¢sip Ir,582 lj. 3 225 081 225081 4 Ot￿re￿￿t￿le Tr•dlng Ath¢b 2019 MemberJNB s￿￿￿?7￿ 5,216 10 993 5.¥J 1$28& 2019 k Sakns RoyahiesR#Ew•d Re91sti•l￿n F• 42 232 Q232 ￿750 2J20 20t• ¢4in9 129,048 1,535 ioj 1171 1>5.)83 1.67B CL¥YgUt•r LelWIW J•1¥ Poage Shippi 24.618 i.e Publkky M•thn9 ￿01t T￿¢m￿¢t1¥I 51 PKk Pr•n¥LYnl 7SOZ 14 995 21.999 3.845 62.1fAI 148 b)¥¢ep51kelMrrn 14 YJ) 2D20 Grnn ¥J¥O 2010 3020 Dlrrtt Supptsrt 1Tr40 11 219.471 897076 R￿1￿Cl Perkortsy￿h UiiLiyie4 111318 ￿, 3Q1• DI￿[ exr*fiJltyJre 2DI• 2019 2019 2Q1> Gratlls Gllts ITr Support Tatal INo¢•l01 INDt• RasÈarchint•tre Re1￿llf lli8bth¥ Roll￿. ol P4rsorn Dwb•t•B 451948 436.370 6gJ.31a 797 777 23

Diabetes Research and Wellness Foundation Notes to the Flnaneial Statements ICcntinu8d) For the year ended 31 December 2020 Grant Aw¥rd5 2020 2019 Univérsity of Bristo￿. Non citrvl Fe1th95hw 2016 Univ¢rsty ol Oxfoid Unwrsity Df Exdpr{previously Xings's CJge Lcraoni-Non CSnKal KYJ$ Crlleqe London- 2019 Pumo Pthliry Awartt KIr￿ eoiifjyB LondE￿- ￿19 Pump ￿Nn1￿jA￿trO UnfftTstydOxford- 2019 Pump Pthin4A Univwsity Df t￿n￿￿-20]g P￿rn0 Primiw AwJ B•rtA Irrfj Tr• London SchoDI & Oep.JMry-Pwrg unpl￿SItytt LirKdn-2019 Pump Prknry Ayrff A8￿￿aTron pourla sur [• Dtht 44.943 I￿ 351 158707 e4.978 14 978 19.&87 19006 864 DthIv3 Wellness Nemvk eAnad Ini4Jrniingisbft•is•n F4thonk re LuThl uh1￿. Reseaw In¥l￿￿te Found6w- Uv4v8Th,tydhlarni unN•r&fy of Bnoioi. 2020 Pump Prim￿4 Av. Unfvfrisity ol CèrntskW- 2020 Purnp unN•rtsity o151rJtht4te. 2020 Pump PrimigAw¥d Un￿911￿ oi Exiwr- 2020 Pump PthirJ AwJ Uni¥Bi•ty of Durthe- Pump PnrnirgAYid Univei$ityDf Ex8tsr. 2020 Pw9 PrimuiiAwaib 40.40> 5a.415 50.fp 20.000 19.921 2D.r 15.093 19.6NJ 331.127 474.109 L•u" Und•irned gNls *ritten t• 146.650 PO.i811 2E9 471 453 941 34

Diabetes Research and Wellness Foundation Notes to the Financial Statements (Continued) For the year ended 31 December 2020 9 Gifts-In.KTrnd The lollowing don81￿)￿s made during the YearWe￿ doirned 8$ Gifls-￿-￿￿ and are ¥a￿ed in accofdance with current market condllions provail,ng ￿efi thè glft was rnad8. Numborof shiw1￿ts Gift$4fi- Kind valu• Shipping Costs 2020 Total 2019 Total 10 Dlrect Charftable Exp8nditur• 2020 2019 Siaff Costs Iseg Note 12) Po$la9e 373.572 141.033 42 e29 13.247 107.114 10,962 1,16S 21 $96 711 318 335,707 191,948 74,475 lo.￿0 151,713 11,989 2,718 19.227 797 777 Mail Pack PrèrniumB Carritrs Grani Costs Lettatshep and D•1• 11 8upport Co•ts 2020 2019 Olh¢r Staff Cos15 Professi￿21 Costs Management Charge 0111￿ ExpenJe# $tsbli$hrnent Expenses 88nk Chargas and Iniere$l PaY Forei9n Exchartg• ILos¥l Provision lor 8gd Debts Oepieciaiio Irrecovgr8bl& VAT AmDunl8 P81¢ lo Audilo Company S8crel3rial Fees B08rd Meeling Cxponsej & Trus1•• Eynsès Other Qverheod Costs S,643 22.012 141.483 82.792 44.276 3.298 5.175 4,524 16,941 93,870 96.808 45.116 2.516 3.002 1.675 7Q 8D1 17.644 350 1,033 71,852 14.405 26,996 58 957 12.454 4Q7 605 Support Cost8 sr¢ alk)coW 10 the Charrta￿a •xpendth of the cttarnty in Wo{￿￿)n to the di¥oGI co$1 Qf activity 12 Wa00¥ and 8al•ri•8 2020 2019 Wag05 and SaLqrieB Social Securily Cog1$ Pansion Costs 398,878 31,138 12 187 442 003 359.083 28,133 10.597 397,813 The key rnanagemenl personnel ef thE ch81ity are the Truslees and the CEO. The total amouThl paid to key mana9èmènl personnel was £66,941 12019" £6S.S641. No employee rÈc•wÈd a salary of m¢ye Ihan £60 OOD dunng thè year12019.. Nil). The average nurnber Dr rulkiime equi¥ant employees thjrmg the yearwas 11.512019.. 111 35

Diabetes Research and Wellness Foundation Notes to the Financial Statements Icontinued) Forthe year ended 31 December 2020 13 Payments io Tr¥siees No tru3lee p¥¥￿ 4uth? farThty Oray¥mr￿¢onntthQn a ITvMee. I￿4¥e0 r￿ul1t￿￿t￿ h thR bar. ¢lrtty or Inahw. Irtyn the thanty T￿$1¢@ ￿p￿Se¥ lof Tr￿ Co6￿18£0412O19 £26 09$] Enl (201D' £28.(thl w•& di￿Y to rnl 14 Surplw ol¢¥M ov•rExwndfrlu 2019 Tho $Ll￿4u5 af aftw Auditors, RemwerJbDn. - Fee rei•bnO to Ibtr FIMrD•lY••f - In ièswtol ne$ audil teryx•L¥ QperoVng Le888 r8nra.s . P￿n., & Wirtty . OtheT As¥els Foieiqn &ycThan98 L￿1 D•pre¢44 1$2 14.405 3.583 3128 25.001 5.115 3.127 24.0 3.002 The ￿￿Pé￿¥. belry • f￿15[•￿ cnwty Is ra bat4e t¢wortt•tyx Inrrtr•yrftt8w81th)nsloithe wf. 11 Tang1)t• fty¢h•rPty U Offlc• 8qulwngnl. Iittin Coal Al l J•nu•ry 2[$20 A¢UKion8 i• Yeet 018wSs In Year Al 31 O•c•mbv2420. 34,032 6.?78 3U.988 Depre¢latton Al l January 202Q ProAd¢d ir the 5wr EIlminJt￿ an Diswl Al 31 De¢EmLw 792Q. $0,782 1.075 O,Z09 26.188 èl Book Vili 31-Dec-20 At 31 tlecemtor 2019 17 O•bto 2020 2D19 Traoe Debtor6 Otr%r DebtOTS Prepayw. Is w*A¢crvvJ I￿ 13,156 13C.354 13g 455 14C,304 All Debtorj EXLWt Wep8vn￿￿tsWefi￿9wl ￿l￿en￿an#￿e ￿￿J[E￿41￿ft￿eTrt Yali 3¢

Diabotss Rosea￿￿ and Wtrllng5¥ Foundaiion Notos to the Financval Statemems Icomnuedl Foriho yèar 31 DeC¢m￿r 2020 l¢19 Tr•d•Cf•diL Atcrualsind Irt¢T .741 5J.g 3￿7 08242 7t¢ Grnryis P•vl•tDrth• Y¥1 IH•P4••1 453k¥8 Ip•oolaioifnK•(fftr<rffjrn.tNnii In NL41 Iq DelerTdtr¢nl• P•l•w1•d In Yew I￿OrnI¢￿FwD S7￿ Qw¥wX2 •4t l JitsJry nll• fy￿rti Y•vr Y•w rtlilp?Ir 2010 02SO I52e• i?J 118ZO i¢ 160W I￿1?1￿ I￿4 2831 310 •t Trtwf•rfrn 1019 i Y•4r Y+4r aQlg 2470 oa7¢ D2Q• Atp4rn E15?eB A￿¥ T¥t&i C￿rTer1￿? CuiMniL1¥141 4.8 3 300,370 J252 114 -5.574 2 98949& 3T

Diabel•s Research and Wellnès$ Foundation Notes to the Financial Statements Icontinuedl For the year ended 31 December 2020 2f Pyrn•nlÈo CWn•Gt•deh￿1￿ IOt$ Conn•ct¥d ChwÉty T¥ii hi Ik•y••r 141.4& pa070 ¢la ¢uMI.thi• I¥iM MfLr¥J r￿￿r￿Mr1 knvoi4Swig0 I•Lurf U￿￿er¥¥. Nuivay 4ts4riJ P46Q•ty Lvrf UDiwyi4ityJn Nwwy. 2 Ai•rptrXliur ppvrl4 Ilr J. yrtor go•rc QfTrJlt L4th• ••Jde411•d Ir fTw¢e Tru•ps Dt Im•5￿C￿¥ ¢Mi¢yin Sw¢ Fufth•rtJ•t4ils rqwoiry IhB I￿Tr￿>￿ RIP ZZ Fln¥KIii ,ty h•ifww￿lC0r￿b1Vtsrf£2l? 12019 ¢421 w•nti D•t•w2020 Ab 19 In 2021 P•n¥• In 20 P•vo• In 1023 PIY•oi• In2024 329241 940Y s32.￿1 8,1 27 2J Dptl•llw L•aM• A131É1 Dwc•nbor1¢20, thbthofiiy T￿10 Fr• Y•• Y• 22.167 9T4 3M2 The ie¥s• prowO•¥.'ol￿D discouth•dwodts ￿ io 21 R•ctsnclllatW ¢f N•1 klov•rrwi Fundy N•tCMhFk>•lmmOp•iAtityAe¥ 2019 Fur.tt5.5U.'P￿lD0liCit) Adtt Owgciaii¢n •Qu¢t Inwrjil Inc¢meJPI¢My In 1458.153 216 109017 N•1 C35huypU.r. Op4'•1JrtKtwl ISXFY 26 M•rr*era' Th• ￿￿￿￿￿11￿￿ IS J mmwny11￿d ThTh)WswSIIWIB-51hthltyk•knite41¥£1 38

Diabetes Research and Wellness Foundation Management Information based on the Financial Statements For the year ended 31 December 2020

Diabetes Research and Wellness Foundation Detailed Income and Expenditure Account For the year ended 31 December 2020 2020 2019 Income Gifts in Kind Gran15 Receiv6d Donations Lottery Programme Membership Subscriptions Legaciewln Memtrrusts Received Gift Aid Other Iricom 22.721 760.750 8.185 6.216 749.810 108.582 16.121 927.491 7.872 10.993 317.804 225.081 20,953 1,672,395 1,510, 194 Expn#e¥ Gills In Kind Granls- UK Grants- DRWF Inc Granl$- Canada Gr8nls- Europe Grants Costs Printing - Educatlon81 Support Mail P¥¢k Pr8mium$ Prlnling - Mail P8ck$ Carriers . Mall Packs Artworks Lettershop Caging Cosls CJTnpuler Charge$ P03tage & Shippin9 List Renlal Lottery Cgsts Marketing Costs Publicrty T8lem8rk8ting Event & Rètre81 Co818 Priz$s GIK Shipping Costs M8nagetnenl F90 Salaries & Other Staff Costs offi￿ Costs VAT Irrecoverable Depreciation Chargt for Year 018PDsal ol Assets Provision lor Debts Foreign Exchan98 Differn(* 238.892 50.415 (71)0) 363.001 50,004 40,943 2.718 43.516 172.951 36.293 13,667 1,165 30.813 122,109 13,470 12.497 20,345 125,048 3,038 157,543 4.430 7.175 280 15.578 16,192 135,363 3,903 218,566 5,935 15.028 17,753 14.500 66.174 14.81x1 141,483 447,646 172.388 70,801 1.075 93,870 402.337 207,25S 71.852 1.033 131 5.175 1,674.390 1.979.046 Net Surplus I IDefi¢it)

Diabetes Research and Wellness Foundatlon Detailed Income and Expenditure Account For the year ended 31 December 2020 .927.4•1 7,8f2 10, 17,8111 25,( 10.194 63.00. . AO,943 2.9 ."•i16.1 *y 3,9 3.8 4D2. 207.2 71, 79,

Diabetes Research and Wellness Foundation Detailed Income and Expenditure Account For the year ended 31 Dec8mber 2020 2020 2019 Incomè Donalion$ Lottery Programm& Gifts in Kind Gift Aid Repayment daim6 Bank Inlerest Legaciesllnmemffrusls Recewed Member8hip Books Grants Received Other 760,750 8.185 927,491 7,872 108.582 8.101 749.810 6,218 225.081 11.910 317.804 10,993 22.721 10.020 9,043 1,672,385 1,51Q.194 Expen$tr• Gifts in Kind GIK Shipping Costs Gr8nts Payable Grant Cosls Compuler Charges Po81898 8nd Shippino Printing Salaries Other Staff Costs C8gln9 Carriers Letter5hop Llst Rent81 Maikellng Cosis Publicity Mail Paeth Pr8miurns Lottery Costs Telemarketsng Aydil and Accountancy B8nk Charges and Inleroji Paid Foreign Exchange Losses I IG8insl offi￿ Expenses Rent, R#les and Ulilili¥$ Artwork Legal Fèes DepreciatiL)n Travel and Enlertainmenl Annual Events Programm$ Sweepstake WinneT5 Management Fee Irrecoverable VAT Cost of Books Sold Board Meeting Expenses M18cellaneous ProfitlLoss on Di8posal of Fixed assets Prowsion for 8ad Debts 289.471 1.165 3.038 157.543 44.283 442.(￿3 5,643 125,046 12,497 20.345 4430 453.948 2.718 3.903 218.567 78.809 397.813 4,524 135,363 13,667 18,IW2 5,935 15.578 122.109 7,17S 15.028 112,951 3.645 19,8￿9 3.298 5,175 82.7¥2 44.278 16.255 2,St8 3,￿2 .808 45,118 20.397 1675 2.014 17,753 14.500 141.483 70.801 15,441 1,033 4,124 66,174 14,800 93,870 71,852 26.9Q6 131 1,674,390 1.9T9,04T Net Surplus I IDeficltl 2.005 46