ARTHROPLASTY FOR ARTHRITIS CHARITY CHARITY NO.: 1051165 ANNUAL REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 NOVEMBER 2024 Artliroplast), tor ARTHROPLASTY FOR ARTHRITIS CHARITY Icharity no.:1051165 GENERAL INFORMATION FOR THE YEAR ENDED 30 NOVEMBER 2024 Name: Arthroplasty for Arthritis Charrty Registration Number.. 1051165 Address.. 57 Callicroft Road Patchway Bristol BS34 5BU Bankers: National Weslminster Queen's Road Branch 40 Queen's Road Bristol BS8 1BF Solicitors: TLT 1 Redcliffe Street Bristol BS16TP Trustees: Dr Daniela Smith Dr Diana Pomeroy Dr David Coates Mr Jeremy Latham Mr Roger Proctor Prof Mehool Acharya Mr Phil Collard Mr Andrew Porteous Director: Mr Evert Smith Consultant Orthopaedic Surgeon Research Commrttee.. Dr Peter Lachman Prof lan Clarke ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165 OBJECTS AND POLICIES OF THE CHARITY FOR THE YEAR ENDED 30 NOVEMBER 2024 The CharFty was established by Ttust Deed in 1994 and the name and objects were dened in 2012: 1) To advance education into arthritis, joinl replacements and trauma, wrth particular emphasis on hip repla￿ment surgery. 2) To promote research into arthritis. joint replacement surgery and trauma. with a particular emphasis on hip replacements. 3) To disseminate the useful results of such research. In order to further these objects the Charity will: 1) Undertake and manage research programmes. 2) Publish and disseminate the results of that research. 3) Undertake presentations on the results of the research. 4> Organise conferences. seminars and courses on relevant topical issues. The Charty will operale in England and Wales but the beneficial area is national and intemational. ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165> DIRECTOR'S REPORT FOR THE YEAR ENDED 30 NOVEMBER 2024 We remain committed lo funding projects researching and uncovering kno￿rfedge of musculoskeletal and joint pathologies, joint arthroplasty, ways of ensuring success. and possible solutions for problems and failures of joint replacements. The project entitled "3D Patient Specific Instruments (PSI) for Implant Positioning in Total Hip Replacement" lead by Associate Professor Anna di Laura et al at the Royal National Orthopaedic Hospital (RNOH) began shortly after the funding was approved. Several updates were submitted to the charity, and the researchers reported that the project was on target, and they had published papers, engaged in inlemational presentations and received some media Goverage. The publication in the Journal of Orthopaedic Research (https:Ildoi.org110.1002tJor.25971) was "Understandlng the variabillty of the proximal femoral canal.. A computatlonal modelllng study., The authors were A. Ramesh, J. Henckel, A. Hart and A. Di Laura. The aim of the study was to better understand the shape variations that characterise the intramedullary femoral canal which dictates the fit of the prosthetic stem. The presentations include the following: "Understanding the variability of the femoral canal for THA.- a computational modelling study" The European Federation of National Associations of Orthopaedics and Traumatology (EFORT). 22-24 May 2024, Hamburg, Germany. "Statistical Shape Modelling Shows the High Variability of the Proximal Femoral Canal.. Future Gulde to Achieve Target Stem Anteversion". Intemalional Society for Technology in Arthroplasty (ISTA), 28-31 August 2024, Nashville. USA. ' The clinical importance of planning stem anteversion." the use of PSI for femoral osteotomy and version" Italian Society of Orthopaedics and Trauma (SIOT). October 2024. Rome. "Understandlng the varlabllity of the femoral canal for THA." a computatlonal modelling study" DKOU, Odober 2024, Berlin. The media coverage was on Channel 5 fftre Prof A. Hart particrpated in Michael Mosley's 'Wonders of the Human Body" https.l/www.channe15.comlshowlmichael-mosley-wonders-of-the-human-bodylseason-11episode-2 htt www.com lexhi sur .com stories wonders-of-the-human-bod The team were also involved in a two-day exhits'tion at the UCL Festival of Engineering celebrating the 150-year anniversary of the introduction of the first engineering teaching laboratory in the UK. They ran the exhibit 'What will hip suryery look like in 20507- demonstrating some of state-of-the-art surgical planning and 3D printing solutions to the audience. ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) DIRECTOR'S REPORT FOR THE YEAR ENDED 30 NOVEMBER 2024 The RNOH project Couch to SK on 3D assessment of muscle health is on track. Data analysis, dissemination of information and publication is ongoing. In "Runnerfs World". journalist Sophie Raworth explains her experience of Knee MRI scanning with the research team and reports Professor Hart's main research focus. 2. In The Times Peta Bee reported on an interview with Professor Alister Hart 'How cycling can add years to your life.. A new study shows that regular pedalling by over-50s helps the body to stay physically heamhy for longer. 3. In the Doctors Updates Conference Ihere was a talk on Exercise Science by Speakers: Alister Hart, Sophie Raworth, Mike Mosley, Sanjay Shama. 4. In the 40 Marathon Medicine Conference April 2024 there was an invited talk on Ihe effects of sport and eXer￿se on joints and muscles of sedentary and active Indiv￿ua1s. 5. In a press release - The Conversation - an article explains the benefits of wnning after middle age. "One of the best ways to ease into running in mid-life is the NHS Couch to SK running programme. It's designed for everyone. Running is a great way to keep bones and muscles healthy. helping prevent damage and even osteoarthritis. Just make sure to take it slow at first.. We received a letter of thanks from the Dlrector of the ExplantLab, Dr Davld Langton. for our ongoing ongoing support. He also provided an update on the groundbreaking research that they are engaged in. Multiple centres across the country are involved in recruiting patients, with the ultimate aim of acquiring 2000+ patients. The overall research project is focused on the study of immune responses to various types of implants, with the ultimate aim to develop a test which will allow patients to receive medical implants which they are best surted to. based on their DNA. There have been some exciting discoveries in lerms of relationships between blood titanium concentrations and patient reported outcomes and the risk of revision. These findings were presented in October 2024 at the Personalized Arthroplasty Society Meeting in Chicago. The paper on which this presentation was based is will be submitted to the American Knee Society for consideration of a research award at next yearfs AAOS meeting. This initial paper is just the first of what will likely amount to dozens of papers generated from this project. The ExplantLab researchers we will be examining the relationship between genetics and the risk of infection, polyethylene induced osteolysis, and Ihe effect of robotic surgery on wear scar position. ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) DIRECTOR'S REPORT FOR THE YEAR ENDED 30 NOVEMBER 2024 ExplantLab have also successfully applied for the NHS tender for the provision of explant testing to the NHS Implant Analysis Service. This is a new national service which was publicly launched at conference in Newcastle, in November 2024. On another matter, the organiser of a large national research project, Joanna Shim, invrted the Director and 3 Trustees frorn the Charity to be mernbers of a national Steering Committee to work with the James Lind Alliance Priority Setting Partnership (PSP). The Arthroplasty for Arthritis Charity is delighted to support the James Lind Alliance Steering Group in a new PSP. Established in 2004. the James Lind Allian￿ is a non-profit organization that brings together patients, carers, and clinicians to Klentify and prioritize studies in health research. This collaborative approach ensures that future research aligns wrth Ihe real needs of those directly affected. The PSP is chaired by Mr. Jonathan Gower, the James Lind Alliance Senior Adviser, who leads the Steering Group. The project is supported by the Robert Gordon University in Aberdeen where Joanna Shim is the Chan￿lI0￿S chief researcher. Other health groups including the NHS are also actively participating in the project. The govemment are set to provide huge financial support for the Prehabilrtation project. The project was to evaluate the need for Prehabilitation in Total Hip and Knee Arthroplasty. This initiative aims to address a historically poorly supported area of research - the preoperative phase of patient care Prehabilitation (also called p￿OperatiVe rehabilrtation, or prehab ) is 8 programme designed to help prepare people for surgery as best as possible. It may include exe￿Ise, nutiitional guidance, mental health and wellbeing support. and lrfestyle changes depending on individual needs. The goal is to improve overall heatth and wellbeing dunng the waiting period for surgery. which can range from monlhs to several years. This preparation may lead to better outcomes 8fter surgery. The purpose of this project, Prehabilitation." Priority Sethng Partnership is also to ensure that patients are fit enough to be redirected into the private sector waiting lists. whe￿ patients are passed fit by Prehabilitation they could then not be refused an operation in the private sector or in the operation hubs set up by the govemment. The charity's involvement in this project not only helps to enhance the profile of the Charity, but also identifies the Charity's commitment to research and health care in the United Kingdom. We appointed a new Patron. Via a Trustee's link lo the Earl of Inchcape. she wrote to the Duke of Northumberland who accepted the role of Patron but emphasised that his role would be symbolic rather than an active one. We formally acknowledged and welcomed the Duke of Northumberland to the Charty. ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) DIRECTOR'S REPORT FOR THE YEAR ENDED 30 NOVEMBER 2024 Regarding holding future fundraising events, we again approached the Earf of Inchcape, who is member The Grocerfs Livery Company, London. The Grocerfs Hall was visrted and viewed in November 2024, to gain insight into its surtabilrty for a fundraising event. Further discussion and evaluation by theTrustees will be required in the future. Fund raising continues to be difficult. We have regularly written to various organisations. Our main sponsors, to whom we remain indebted, are The Tompkins Foundation, the Wyseliot Rose Charitable Trust. The Inchcape Foundation and the Joseph Strong Frazer Trust. We continue to be supported by webree.com and Proctor + Stevenson Ltd and are grateful for their ongoing help. We are investigating the possibilty of investing some of our assels. The accounts remain in good order, with adequate funds to continue actively supporting the various research projects on the horizon. ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) PUBLICATIONS, PRESENTATIONS AND CONTRIBUTIONS TO BOOKS FOR THE YEAR ENDED 30 NOVEMBER 2024 Publications 2019-2024 AM Ebied, A Ebied. S Marei, E Smrth Enhancry 8nd prnv￿1ng stnKlural support lor acefabular ￿¢￿s(￿J¢t￿?n in singl8-sl8ge revision forinfection Joumal of Orttwaedu and Traumalol(w - Open Ac£ess: Ebied et al. J Orthop Tlaumatol (2019) 20:23 httpS.'Ildoi.N￿lo.ll861slOl9￿oI￿53 Kout8los AK, T(￿8 AP. Cahir JG, Smrth EJ conpla1K￿ ofMARS MRI findings Mth cup p￿kn. métal I(￿ levels 8nd lunctm in met81 on metal lotal hip arthroplasty Hip Int 2019,. HIPINT-D-174K)232R1- Augusl 2019 Koutalo8 AK. Tnaldson TK. John A. Koulalos AA, Lazennec JY. Smrth EJ One-hour address T￿nn10￿0&S vs Impingeffthr Japanese Arthroplasty Conference Tokyo- February 2019 EJ Smith How successfvl are cemented hip Trplacements /Suryival ofcementsss THR?. J(Nnt Registy data EEMEA Cementless Hip Symposium Amsterdam- June 2019 EJ Smith Temporal chang8 in th8 use ofc8m8nlless stems EEMEA Cementless Hip Symposium Amsterdam- June 2019 EJ Smith DDA, DSA or SPAIRE- What arn the consideral￿n5? EEMEA Cementless Hip Symposium Amsterdam - June 2019 ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) PUBLICATIONS, PRESENTATIONS AND CONTRIBUTIONS TO BOOKS FOR THE YEAR ENDED 30 NOVEMBER 2024 Presentations 2019 to 2024 (continued) Smith EJ DDA, DSA or SPAIRE- What are the c(￿￿derat￿￿s7 EEMEA Cementless Hip Symposium - Amslenlam Skill Centre Amsterdam - 2019 Smith EJ Slubbies- Th8 future EEM&4 Cemenlless Hip Symposium - Amsterdam Skill Centre Amsterdam - 2019 Smith EJ How succèssful aTr cem8nled hip Trplacefflenls?/ Survival ol cemenlless THR- j￿nI Registry dat8 EEMEA Cementless Hip Symposium - Amsterdam Skill Centre Amsterdam - 2019 Smith EJ Tempornl change in lh8 use olcementless femDrdl stems EEMEA Cemenlless Hip Symposium- Amsterdam Skill Cenlre Arnsterdam - 2019 Smith EJ Has Orthopaedic PersP8Ctivè Ch8ng8d in the UK due to Novel COVID 19? Genatric Orthopaedic Association of India - Doctors Teab'me Educabonal series Webinar- April 2020 Smrth EJ Worfr of the Orthopaethc Data Evaluation Panel People's Universty Bhopal. India.. GIRFT in Tolal Hip Arthroplasty Webinar - June 2020 ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:10511651 STATEMENT OF INCOME AND EXPENDITURE FOR THE YEAR ENDED 30 NOVEMBER 2024 General Restricted Funds Funds Total 2024 Total 2023 Note INCOMING RESOURCES DonationslGrants 38 072 38 072 28 580 Gifts in Kind 20 500 20 500 20 500 Interest 305 305 156 58 877 58 877 49 236 RESOURCES EXPENDED Research costs 20 500 20 500 20 500 The Hip Research Project Marketing and PR Administration costs 51672 51672 20 000 716 716 1347 1347 1038 74 235 74 235 41538 NET SURPLUSI(LOSS) FOR YEAR (15 358) (15 358) 7698 RETAINED SURPLUS at beginning of year 270 894 270 894 263 196 RETAINED SURPLUS at end of year 255 536 255 536 270 894 io ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) BALANCE SHEET AS AT 30 NOVEMBER 2024 General Restricted Total Funds Funds 2024 Total Note 2023 CURRENT ASSETS Short-term investments 19918 19918 19 612 Bank 235918 235 918 251582 255 836 255 836 271 194 TOTAL ASSETS 255 836 255 836 271 194 CURRENT LIABILITIES Accounts payable & accruals 300 300 300 TOTAL LIABILITIES 300 300 300 ASSETS LESS LIABILITIES 255 536 255 536 270 894 RESERVES Retained surplus 255 536 255 536 270 894 TOTAL RESERVES 255 536 255 536 270 894 11 ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) NOTES TO FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 NOVEMBER 2024 1. Accounting Policies (a} Basis of preparation". The financial statements have been prepared under the historic cost convention in accordance with the Statement of Recommended Practice: Accounting and Reporting by Charities (SORP 2005) and the Charities Act 2011. {b) Incoming resources and resources experKled'. All incoming resources are recognised once the charity has entitlement to them, rt is certain that the resources wll be received and the monetary value can be measured with sufficient reliability. Liabilities are recognised as resources expended as soon as there is a legal or constructive obligation committing the charity to the expenditure. All expenditure is accounted for on an accruals basis. Grants payable and research costs are payments rnade to third parties in the furtherance of the objects of the charity. Provisions are made vthen the intention to make a payment has been communicated to the recipient but there is uncertainty about either the timing or the amount. (c) Fixed assets and depreciation: All assets costing more than £500 are caprtalised and valued at historic cost. Assels are written off on a straight line basis over their estimated useful lrfe. (d) Fund accounting Unrestricted funds are expendable at the discretion of the trustees in furtherance of the objects of the charity. Restricted funds are donations eamiarked by the donor for a specific PUfPOSe. 2. Trustees remuneration The trustees do not receive remuneration for services ￿ndered to the charrty. 2024 2023 3. Gifts in kind Gifts in kind are made up of the following: Directorfs time 20 500 20 500 The related expense is disclosed as follows: Research costs (directorfs time) Other 20 500 20 500 20 500 20 500 12 ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.-1051165) NOTES TO FINANCIAL STATEMENTS FOR THE YEAR ENDED 30 NOVEMBER 2024 2024 2023 4. Interest Interest on short-tern investments (note 8) General 305 305 Restricted Tolal 305 305 Scottish Widows Bank 156 156 5. Administration costs Computer expenses Licences & subscriptions Postage. Offi￿ supplies, printing & stationery Travel & subsistence Accounting fees 221 152 261 152 109 216 300 1038 674 300 1347 2024 2023 6. Short-term investments General 19 918 19 918 Restricted Total 19 918 19 918 Scottish Widows Bank 19 612 19 612 13 ARTHROPLASTY FOR ARTHRITIS CHARITY (Charity no.:1051165) REPORT Independent examinerfs report to the trustees of the Arthroplasty for Arthritis Charity I report on the accounts of the Arthroplasty for Arthritis Charity for the year ended 30 November 2024 which are set out on pages 10 - 13 Respective responsibillties ol trustees and examiner The charity's trustees are responsible for the preparation of the accounts. The charitls trustees consider that an audrt is not required for this year under section 144{2) of the Charities Act 2011 (the 2011 Act) and that an independent examination is needed. It is my responsibility to: examine the accounts under section 145 of the 2011 Act follow the prO￿dureS laid down in the general Direclions given by the Charity Commission under section 145(5)(b) of the 2011 Act; and - to state whether particular matters have come to my attention. Basis of independent examinerfs report My examination was carried out in accordance with the general Directions given by the Chartty Commission. An examination includes a review of the accounting records kept by the charity and a comparison of the accounts presented with those records. It also indudes consideration of any unusual items or disclosures in the accounts. and seeking explanations from you as trustees concerning any such matters. The procedures undertaken do not provide all the evidence that would be required in an audit and consequently no opinion is given as to whether the accounts present a "Irue and fair vievl, and the report is limited to those matters set out in the statement below. Independent examinerfs statement In connection with my examination, no matter has come to my attention which gives me reasonable cause to believe that in any material respect the requirements: - to keep accounting records in accordance with section 130 of the 2011 Act; and - to prepare accounts which accord with the accounting records and comply with the accounting requirements of the 2011 Act have not been met. Name: EA Redelinghuys CA(SA) Professional body: South African Institute of Chartered Accountants (Membership no.: 291175) Address: 3 Kildare Lane Newlands 7700 Cape Town South Africa 25 July 2025 Chartered l Network Accountants Wcrldwth i Mernber Date: 14