The Brlthh Soclety of Toxleologlefyl P*tholoy for the ye*r ended 3th SeNwbtr21ni arlty DO: 1043793 BRITISH SOCIETY OF TOXICOLOGICAL PATHOLOGY 8STP Secretariat BSTP PO Box 819 Harrogate North Yorkshire HGI 9XF BSTP Tel- 07894 123 533 Email.. Web Site.. h www Trustees, Annual Report for the period 1st October 2020 to 30th September 2021 REFERENCE AND ADMINISTRATION DETAILS Charity Name British Society of Toxicological Pathology other names charlty Is known by: BSTP Reglstered Charity Number: 1043793 Charity's principal address: BSTP. PO Box 819, Harrcoate HGI 9XF, North Yorkshire, UK Names of charity trustees who manage the charlty (from November 2020 to November 2021) STRUCTURE, GOVERNANCE AND MANAGEMENT Type of governlng document: Constitution adopted 16th November 2017 How the charity is constituted: Association consisting of 179 members as of 30th September 202 1 Trustee selectron methods: Trustees are elected by members every two years and In the case of the Chair of the Education Subcommittee, every 4 years at the appropriate annual general meeting. ADDITIONAL GOVERNANCE ISSUES All trustees give their tlme voluntary and receive no remuneration or other benefits. OBJECTIVES AND ACTIVITIES Summary of the objectives of the charity set out In Its governing document The two stated constitutional aims of the BSTP are: To foster educatlon and training in toxlcological pathology. To advance pathology for the public benefit in all its aspects pertaining to the effects of extraneous substances and environmental agents to which man or other specie5 are exposed by design or adventitiously. Pagelof6 BRITISH SOCIETY OF TOXICOLOGICAL PATHOLOGY 85TP Secretariat BSTP PO Box 819 Harrogale North Yorkshire HGI 9XF BSTP Tel.. 07894 123 $33 Wèb Site.. h In order to achieve these alm5, the soclety kept In mlnd the Charity Commlssion's guldance on public benef6t at all Trustee (Council) meetlngs. The Trustees (Councll), together wlth 3 subcommittee comprised of 13 other members of the soclety work together to organlse and promote a programme of continuing education symposia {CES) and other events which are open to members of the society and also non-members Including studentslresldents and those at the start of thelr pathology career, These symposla also provlde an opportunlty for toxicologlcal and dlscovery pathologists land other scientists working with animal models), clinlcal pathologists and toxicologists as well a5 non-clinical regulatory scientlsts to learn about recent sclentific advances and enhance thelr contlnulng profe551onal development. Two CES are run each year wlth the BSTP provldlng at each event, at least one free place and also reduced registratlon fees to indlvlduals worklng withln an 'early career- environment, for example stipendiary sttsdent5/researchers studylnglworklng within a relevant sclentiflc field le.g. PhD students), veterlnary pathology resldents and professional trainee pathologists workbng towards a professlonal quallflcatlon {resldent51 or gabning more experience wlthin the field of toxlcological pathology, An Annual Sclentlfle meetlng Is also organised (sometimes In conjunctlon wlth other socletles or organlsationsl In order for attendees to learn about recent sclentiflc advances and enhance thelr contlnulng professional development. Agaln, the BSTP are able to provlde at least one free place and additlonally reduced regI5tratlon fees to indbviduals worklng within an "early career" envlronment at thls event. The Annual Sclentlflc Meetlng also enables Junlor members of the professlon to present posters or speak about their research In an Informal setting. Other short sclentific meetlngs may be oroanlsed on an occasional basls. Addltlonal detalls of obJectlve$ and a¢tSvltles As part of the objectives stated above, the soclety holds meetlngs and promotes sclentlflc research and publlcatlons relating to toxlcologlcal pathology. In additlon to the Trustees, the BSTP has an Education Subcommittee comprlslng approxlmately 13 volunteers, who, uslng their expertlse, are able to encourage, help and advlse those new to the profession to organlse events. For all events, a volunteer Is appolnted as the Scientific Organiser and they (wlth help and advice from the Trustees and Education Subcommittee) organlse the programme and lioise with all speakers and any other organ15er5. Wlthout the contribution of the volunteers, Trustees and the Educatlon Subcommittee, the 8STP would not be able to run these events, which attrart people to attend, not just from the UK an(J Europe, but also from the USA and Asia. Whlle the aim for all events Is to break even, any surplus funds achleved are used to offset any deflclts and enable the BSTP to provide the free place and reduced registration fee5 at future events for those working within an 'early career" environment. Additionally, the 8STP is able to provlde bursaries (on request) to help towards the cost of reg15tration and travel from interested members and non-members of the BSTP. Summary of the maln achievements of the charity durlng the year In 2021, due to Covid-19 restrlrtlons, both CES were held as online events (vla Zoom) i.e. CES 3: Carcinogenes15 (March 202 1) and CES 4.. Respiratory System ljuly 2021). Page2of6 BRITISH SOCIETY OF TOXICOLOGICAL PATHOLOGY 8STP Secretarlat 85TP PO Box 819 Harrogate North Yorksh5￿ HGI 9XF BSTP Tel.. 07894 123 533 Email.. Web Slto.. ww. The 2020 Annual SclentifSc Meeting whlch wa5 Postponed in 2020, was Instead held onllne in November 2021. The BSTP 2021 AGM was held onllne on 26 November, 2021. Durlng 2021, slx weblnars were held In conjunction wlth other Societies (all free of charge). These were: BSTP/STP Webln3r December 2020 Dr Laura Janke Dr Kourosh Saeb- Parsy BSTP/STP Weblnar May 2021 Dr Elizabeth Neyens ESTP/SFPT/BSTP and ECVP/ ESVP 4t￿) Joint Webinar June 202 1 Dr Helen Booler Dr Ken Schafer Dr Elizabeth Neyens Pathology of Mlce with HLtmanised Immune Systems (Teaser for 2020 ASM, postponed to 2021) The Fog Disslpates.. Inslght Into Pulmonary Effects of Vaplng Ocular Pathology Rita Deuchande co-organislng on behalf of BSTP BSTPISTP Weblnar September 2021 Dr Arlln Rogers Dr Wendell Davls ESTP/BSTPISFPT and ECVPIESVP 5th Jolnt Weblnar October 2021 Prof An(Jreas Belneke Dr Hennlng Hvid Prof Jerome Abadle Dr Thlerry Flandre A PathologI5t Perspertive on the Non- Cllnlcal Safety Assessment of GalNAc- conjugated RNAS Therapeutlcs Translatlonal Animal Models of Dlsease Rita Deuchande co-organislng on behalf of BSTP BSTP/STP Weblnar November 2021 Prof Alessio Ciulli Dr Kevin Moreau Dr Clare Hoover Proteolysis-Targeting Chlmeras IPROTAC).. Drug Development and Safety Perspectlves BSTP tralnee engagement - Due to the shortage of toxicological pathologists In the UK and Europe there is a perceived difficulty In fllling vacancies in the Industry. The BSTP Is st511 worklng on a number of inltiatlves to engage wlth veterinary studentslgraduates and to provide opportunitles for them to make a career in the industry. Different Initiatives were carried out in 2020 and 2021. Trainee Industrial Placement Programmes offered at GlaxoSmithKline and Charles River were postponed until 2022. Despite Covid- 19, engagement activitie5 contlnued in 2021 Includlng 'Roadshows"/careers talks at the Universlty of Bristol (careers event for 3rd year veterinary students) and Cllnlcal club talk (final year veterlnary students). The BSTP Council trainee representative {Rebecca Terry) has also been Invlted to sit on the Unlversity of Surrey 'Diverse Careers" panel in 2022. The trainee representative 15 in discusslons with The Veterlnary Record about a 'Vet Futures, article on toxicological pathology and continues to serve as a point of contact for interested residents and informal conversatlons. In addition, the trainee representative for the BSTP Education Subcommlttee l Roy Wakefield} has updated the tralnee Ilst and utilised the online tralnee register at the Royal College of Pathologists. Page3of6 BRITISH SOCIETY OF TOXICOLOGICAL PATHOLOGY 8STP seC￿lar￿t 8srp PO Box 819 Harrogate North Yorkshire HGI 9XF BSTP Tel.. 07894 123 533 Web Site.. h ww. BSTP sponsored publlcations Toxicologic Pathology continues to be the official journal of the BSTP. The BSTP White Paper revlew on Inhaled biologics was published in Toxicologic Pathology in February, 2021. In addltion, the BSTP Counc51 reviewed and endorsed six "Polnts to Consider" publications for the Scientific and Regulatory Pollcy Committee of the Society of Toxlcologlc Pathology, most of which have now been publlshed in Toxicologic Pathology. Digital pathologv Strategy Due to the Covld pandemlc, the dlgltal strategy group did not meet to report back to the BSTP Councll meetlngs durlng 202012021. New pollcles Implemented No new pollcles were adopted from l Ottober, 2020 to 30 September. 2021. Interactlons with other socletles and profe$slonal bodles durlng 2019 - 2020 Royal College of Pathologlsts Committee (SAC) for Toxicology I ltrio BSTP hLIS had fomial representatlon on the Speclality Advlsory So¢lety of Toxlcologlc Pathology (STP) - The BSTP and STP have a memorandum of understanding to share educatlonal material to help the STP develop educational events within the US, based on the BSTP model. The BSTP also provide volunteers as follows.. BSTP Representatlve on GESC of the INHAND Inltlatlve Journal Assoclate Editor5 and reviewers Journal {SAGE) Liaison Podcast Manager for Edltorial Board In 20201202 1, the srp and BSTP continued to collaborate and Jolntly organlse four educatlonal weblnars (see above). The BSTP organlsed educatlonal content and the STP provided the informatlon technology 1nfrastruttu￿. European So¢¢ety of Toxlcologlcal Pathology (ESTP) the BSTP has a volunteer observer on the ESTP Board Izuhal Dincer} and also provlde5 funding towards a sponsored award - the Goplnath Lecture Award. This was not awarded Sn 2021 due to the online presentation of the ESTP meetlng in September 2021. The BSTP donated É1391.87 IEUR 1600 euros) to the ESTP to finan￿ jolnt ESTPIBSTP webinars durlng 202012021. Other Interactions During the last year, the Presldent other global toxicologlcal pathology has held Jolnt teleconferences wlth Presldents of Communlcation: Newsletter, Social Medla, Journal and Webslte BSTP Newsletter - Two Issues of the newsletter in standalone pdf format were publlshed In December 2020 and July 202 1 wlth individual contributions posted to the BSTP LlnkedIn group. BSTP Journal Toxicologic Pathology (josnt with STP) two BSTP Coiiv.rTI rnFrnhprF ivnrked with the publishers and the STP as Associate editor (Peter Hall) and Podcast editor respectivelv, during 20201202 1. There are also approxlmately five members of the Editorial Board, who, coincidentally Page4of6 BRITISH SOCIETY OF TOXICOLOGICAL PATHOLOGY STP Secretariat BSTP PO Box 819 Harrogate North yorkshi￿ HGI 9XF BSTP Tel.. 07894 123 533 Emall.. Web Site.. htt V4W. st re also member5 of the BSTP. The BSTP continued to offer a preferential subscription rate for the Journal to members In 202012021. BSTP Website Volunteer help ensures that the slte is working well. However, the BSTP may, In the future, look to expand the use of the website to include access to slide sets from the EPSR. Addltlonal detalls of objectives and activities The BSTP organised the following events in 2021= Virtual Continuing Education Symposium 3: Carcinogenes15 2nd - I Ith March 2021 Tuesday, Wednesday, and Thursday 13.00 - 16.30 (GMT+O/UCT+O) Approved by the Royal Society of Biology for the purposes of CPD, this event counted as approxlmately 54 credits. Approximately 17.5 hours of educational activity was recorded on Attendance Certificates. Virtual Continuing Education Symposium 4= Respiratory System 6th- 15th July 2021 Tuesday, Wednesday, and Thursday 13.00- 16.30 (GMT+iiucr+l) Approved by the Royal Society of Biology for the purposes of CPD, counted as approximately 54 credits. Approximately 17.5 hours of educational actlvity was recorded on Attendance Certificates. FINANCIAL REVIEW Brief statement on the charity's policy on reserves The BSTP has a reserves pollcy in line with Charity Commission Guidelines and the current reserve fund stands at £57,732, all of which is unrestricted funds. This fund is held to allow the Society to meet any unforeseen expenditure that may occur. A review of the reserves policy in November 2020 by the Trustees resulted in the view that the BSTP could stlll continue to meet its current obligations for a period of approximately 2 years- and that, in the event that the funds fall to E30,000, immediate action will need to be taken to avoid the posslbility of the society incurrtng further deficits. The next revlew is due before 30th September 2023. Details of any funds materlally In deficit None Other financlal review details The BSTP'S maln source of Income Is membership subscriptlon fees and any surpluses achieved from the events organised. In addltion to this, the BSTP receives a small amount of fundlng from website adverts, donations and bank interest. The majority of income is applied to the BSTP'S related activities i.e. educational events, enabling bursaries or free attendance to those in the early stages of their careers, as well as part-time secretariat and financial help. Page5of6 BRITISH SOCIETY OF TOXICOLOGICAL PATHOLOGY PO 8ox 819 Harrogate Nopth YorksiMrE HGI 9XF BSTP Yd: 07894 123 533 OTHER OPTIONAL INFORMATION Puture plans Durfng 2022 the Bsfp wlll contlnue to organlse educatlonal events, so that those who have prevlW￿Y attended have the opportunlty to complete the full cyde of symposla. These events wlll be held vlrtually (as Zi)om meetlngs) wlth the alm that In 2023, Cwndl can conslder whether some or all of these events can be organlsed a5 face-to-face events. The events In 2022 Include CES 5 on the female produrtlve system (Morth. 2022) and CES 6 on the male reprodurtlve system (July. 2022> The 8STr would also Ilke to try and reverse the hlstorfcal trend of decllnlng membetshlpl consldered largely due to an agelng workft)rce, fewer trdlnees as well as Industry consolldatlon. To do thls, the soclety hopes to reach out to those In experfmental medldne or toxlcology In order to establlsh thelr needs and If necessaryi offer them the oppartuntty for relevant tralnlng. Addltlonallyl by Increaslng collaboratlon vdth other socletles for meetlngs, the Bsfp wlll alm to provlde relevant educatlon ftir sclentlsts In other dtsclpllnes. Ded•r•tlon The Trustees dedare that they have approved the Trustees, ￿pOrt above. Slgned on be. Slgnatur•: Full Name: Posltlon• Page6of6 The Brltbh Soelety orToxI￿1oglellI Pilhology (Charlty nllmbcr 1043793) m#nclal Jtstements for th¢ y¢ir onded 30th S¢p¢¢mber 2021 Contents ge Iwjependent Examlnerfs Teport Stslem¢nt offlnanclal actlvliles Balanc¢ sh¢•¢ Noies lo the flnanclal stalem¢nts Tbe Bri¢ish S￿IEty ofT•xk•*ical P•tholoty (Cbarlty #mber A043793) I rewi on the accounts ofTr British So¢lety of Toxiwlo8k41 Pathology (eharity nwnber 1043793). for th¢ y¢4r ended 30th Seplcmber 2021. which #e set out Mes 2 to 9. Th¢ dwi¢ys Irustees are vesp(wibk for the preparntion ofiFK Charli￿ tTus*es consider th￿ an audil is not required this year Under section 14q2) of the awilits Act 2011 (the 2011 Act) and that an independeni Having salisfied myself that Ihe charity is not I￿11( compftny law and is eli8ib]e for indeper*le examination, il is my responsibility to: examin¢ the ￿coUnts sedion 145 of Ih¢ 2011 A¢L to follow the prncedures laid down in the Genernl DiRctioAs given by ilx Chority Commission under Sectic￿ 14515Xb) of the 2011 Ac( and lo stst¢ whethu ￿tiCular mat*rs have come to my al¢¢nI1￿. B*sls ofind•peodMt ex•thlMVs statew￿( My cxaminalli￿ Wds wried out in XC0rd￿ DIrK¢1￿ giv¢n by the Charity C(qnmission¢r. An examination includ¢$ * Teview of th¢ %¢￿ntIng re¢ord5 kept by the charity and a compaTison of ihe a¢￿unts p￿Thi¢d with those reconls. It also incI￿leS considerniion of any unusual iterns or disclosu￿$ in the accounts. and seeking explanations from th¢ tr￿5*¢$ Co￿¢ming any S￿h martern Tr pm¢edurts do not provide 411 the evideJKe thai would be required in 8n 8udiL armj CQJbsequentty ￿l￿10n is given as to whether the a¢ctxmts present a and fair view and the repxt is limited to tIKw mattern s¢t s)ul in th¢ ststement below. l•depeadent exwIne￿# $t•tem¢4t (l) which gives me rtasonabk believe thL in nwterid TespecL tk TequiremeTrts to keep proper a¢¢C￿￿1nB reconls in ￿el¥danc¢ wilh s¢¢tirn 130 of the 2011 A¢tr, aml lo preP￿e xcounts )￿iCh xcord with the ￿CO￿tIl¥ reeLYds and eompty the ￿Unting uirements of the 2011 Aei have been iy {2) to which. in my opinioo attenlim shththl be drnwn in LYdEr kn enabk D prop¢r und¢r51onding of th¢ 15th February. 2022 S*r*h ACA FCCA CTA- l•d¢pad¢At E%•uloer The B￿¢r ParlneThhip Limtted 24 High Streei Pateley Brid8¢, Hairogate HG3 5JU The Brlthh Soclety of Toxlcological P*thology (Chirity number IIM3793) Si•¢¢ll￿At of Fin*n¢l*l Activities ror th¢ year euded 30tk Septmb¢r 2021 UArtstrl¢ttd Restrkted Tot*1 Tothl Note Fumds FWD 2021 2020 In¢omlng aAd endowmffits from: Donations and leg￿1¢5 Charitable acltvilies Investments Other 131 47,620 3.095 49,522 23 1,126 47,620 Totsl 48J56 48.556 53,766 ExpeDdllure on: Ralslng funds Charitable actlvltles 23J65 19J48 23.365 19.348 47,317 19212 io Totsl 41714 42.714 Net 8alnsl(10$5es) oft Inveslrnefits Net Incomel (expendlture) Transfers beh¥een thnds Oth¢r re¢o8nlsed 8ainsl{10sses) Gainsl{losses) on revaluwion orrixed ass¢ A¢luarial gainsl(losses) on defined ¢ontribuliort $chemes te 17) SIX)n%￿hIp of 2019 ASM ESTP weblnAr eontribution Combined liability Ins￿￿¢ Bank fees R¢gonline fees Surnup fees Royal Society of Bidogy Subscription Website costs GoReni cosls Journal of ToxicologKai PatlJolo&v 14.680 14,680 40,596 iJ92 439 1.392 439 419 161 1269 25 7(Ki 485 3.(K)2 2.557 700 72 485 3.1x12 1557 23.365 2.872 47 The Brlttsh Soclety ofTo%l¢okngl￿l Pathology (Cbarlty ttumber 1043793) Notts ¢0 the nn*tteiil ststeme*ts for the ye*r ethded 39th SQ￿mI￿r 2021 IIX Other expew U•r¢strithd Restrided Total Toial Fyfjds Funds 2021 202• Independent examiners fees Secretsrial expenses (see below) Counril & Edusubcom medin8 Treasurers exp¢n8¢s Mlsc. expenses DAla protection wistr￿10n 1.548 17.468 1,548 17,468 1.530 17.199 297 35 448 35 35 SeeretArlal expen Courier & posia8e Prfn¢ln8 and staiiortry Telephone & In*met Secretarial- CPD Seminar May 2020 SC￿e￿rial & bookkeeping costs 374 374 85 164 383 153 672 15.795 16.845 17.468 16.845 11. D¢bton U•r¢8trlel¢d Rmtrleted To¢*1 FuDdJ Totsl Fundj 2021 2020 CES5 CES6 BSTP 2021 ASM 52 52 52 52 282 386 11 CAgh It ba*k Ind l• hand U•rntrieted Restrkted Total Funth Totsl F¥ttdi Fun 2021 2020 Bank deposil xcount Bank ¢UTrent ac¢ou 50267 20,581 50,267 20,581 70.848 50.262 9.537 59.799 PAge 7 The Brl¢tsh So¢lety of Toxleologic41 P*tholo (Charlty numb¢r 1043793) Notes to tbe nn#th¢i41 statements for th¢ y￿r ended 30th September 2(121 13. Cr¢dltors: Amouuts falllng dut wlthin one y￿r UDrttlrle¢ed Restrlettd Total Funds Total Fulldj Funds Funds 2021 2020 Accruals R¢payments to be made I￿orne rtteived in adVa￿e 2J07 ijoo 9.694 13,501 2,507 3,410 4,500 13,501 7.910 The charity's a¢tivilies fall within the exemptions afforded by the provistons of the Income and C(wration T￿eS Act 1988. A￿ingly. there is no iaxation ch8rg¢ in these accounts. I& Al81￿1• of net assets between fllnds Vnre5trf¢ted Restrleted Total FMnd$ Totsl FM*d8 Funds Funds 2021 2020 Fund balances ai 30th Semember 2021 r¢pTesented by: Cwr¢nl assets Current liabilities 71,234 13,501) 57.732 71.234 (13,501) 57.732 59,799 17.910) 51.889 The Brltlsb Soclety ofToxlcologle*l P•thology {Ch*rlty number IIM3793) Not¢5 to the ￿#￿ti•l ststem¢Dts for ¢be year thd¢d 30th Sknemlv 2021 l& Movements ID fund5 l#comi•% O¥tioln8 lort 2020 r¢JoureeJ rewureu Transfers Asat 30 Sep21 Unrestrlcted fu￿5 Restriclcd funds 51J89 48556 (41714) 57.732 Trtal funds 51.889 48.556 (42.714 57,732 17. Imdividual aetfvity wform*Aee In¢ome received from t£tivities (vwised by Ihe Society is reco￿1$￿ in the Statement of Financial Adivitles gross of expeThlilure. However. in the opinion of the Coun¢il, it 1$ more importanl to retleci the clm￿[bUtion made by individual activilies iowards the Society's resources than 10 show lolal income and exFenditsJre. Theref(*< as part of the accoun￿ the detail below has been produced ih demonstrates e￿h activities, inc￿￿ and exp￿di(￿e to show tl% net mlt and the contribution made to lh¢ Society. 2021 s¥rplv (loss) 2020 surplusl {loy) Meetlngs Out8OiDI BSTr AThrn￿ ScientifK Meaing 2019 BSTP Anwai Scientific Meeting 2020 CES3 CES4 23,446 20.312 14.080 7599 7.081 Il713 12.082 34.391 14.080 19.712 35.528