## **Trustee Annual Report 2026: The GEM Appeal Registered Charity Number 1040083** 30 May 2026 GEM Appeal Trustees annual Report 01/01/2025 – 31/12/2025 The Royal Manchester Children’s Hospital Genetic Trust (GEM Appeal) is constituted by Deed of Trust and is a registered charity, number 1040083. Its address is 6 Yealand Close, Bamford, Rochdale. OL11 4DL. The charity trustees at the start and end of the year were as follows: Mrs Karen Johnson (Chairperson) Mrs Katie Duxbury (Vice Chairperson) Mr Garry Whitworth (Treasurer) Mrs Wendy Mills (Secretary) Mr Peter Johnson Mrs Joy Whitworth Mr David Howles Mrs Lynn Howles Mrs Judith Paraschack Mr Robert Rawsthorne Our annual AGM took place, as usual in January (2026) and all the officers of the charity were re-elected to the positions they held the previous year. Due to ill health both Mr and Mrs Howles tendered their resignations which were reluctantly accepted by the remainder of the trustees who thanked them both for their long and outstanding contributions to the charity. The charity is currently looking to replace them but by constitution it is still well within the requisite number of trustees and confirmation of the resignations will be in the annual report next year. The year ending 31 December 2025 was discussed at length and the fundraising activities were reviewed. These included the following events: Karen’s 10k sponsored walk The Strawberry Sparkle Ladies Lunch The Annual Quiz night The Welders Ball The Christmas Afternoon Tea As mentioned in our previous report, Denise Welch, our patron, decided that she was unable to continue to host the Winter Ball and be involved with the charity to the extent she had previously and 2025 was the first year without the ball for 21 years. The effect this had on the charity was discussed at length and is very noticeable in the revenue and income generated for the year. We are still looking for potential replacements for Denise but are realising that finding somebody to do what she did is going to be very difficult and time consuming. That said we were invited to be 1 of 4 charities to be beneficiaries of a ball taking place in early March 2026 which proved to be very successful and will be reported on in the TAR for 2026. Whilst the funds that came our way did in no way match what we raised at our own ball they did replace some of the missing funds and we were invited back to be beneficiaries in March 2027. We are also pleased to be able to say that our fundraising efforts did enable us to continue the funding of the research scientist and in February 2025 we paid out the sum of £49650 which allows her to continue her research for another 12 months. The other great news discussed was the stem cell therapy developed and administered at the Willink Unit seemed to have cured a boy from America of Hunter Syndrome. There is still a long long way to go but this is absolutely fantastic news. We have had a conversation with the Willink and confirmed that they would like us to continue fundraising to pay for another 12 months for the research scientist. This would run from the start of July 2026 to the end of June 2027 at which point, even though the scientist will still be in the employ of the Willink Unit, they will be in a position to charge for her work and findings and thereby fund her own job. Her work has proved to be really successful and is adding to the works of the Willink Unit and benefitting patients greatly. With this in mind the charity will keep its aims the same and with a carry over balance at 31/12/2025 of £56383.77 we are confident of being able to fund the scientist for the period requested. Our chairperson Karen ended the meeting by once again thanking all the unpaid trustees and volunteers for the amount of time and effort donated to the charity and the undoubted effect it has on its ability to continue raising the funds it does. RMCH GENETICS TRUST {GEM APPEAL) FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2025 RegIStor￿ Charlty Number: 1040083 RAA Thompson Jones Business Solutions Limited Chartered Accountants 2 Heap Bridge Bury BL9 7HR RMCH GENETICS TRUST (GEM APPEAL) Annual Report and Financlal Statements for the year ended 31 December 2025 Contents Page.. Repx)rt of the Trusleeg Ind8pendÈnt Examin8r's Report statement of Financial Activities Baance Sheet 8-11 Notes forming part of the fi￿ar￿la1 statements Trustees Mrs Karen Johnson Mrs Lynn Howles Mr Garry Whitworth Mr Peter Johnson Mrs Joy Whitworth Mr David Howl8s Mr Robert Rawsthorne Mrs Judith Paraschack Mrswendy Mllls Mr5 Katie Duxbury Chair Secretary IReslgnad} Treasurèr Trustèe Trustea Trustee IReslgn¢dl Trustee Trustèe Trustee Trustee Contact address 53 Waingap Rise. R￿hdale. OL12 9UB Registered charity number 1040083 Accountants and Independent Examiners RAA Th)mpson Jones Business Solutions knmited. 2 Heap Bridg8, Bury, BL9 7HR Bankers Lloyds Bank, Salford Shopping Cenlre, 10-12 Hanklnson Way. SaKord, M6 &JA RMCH GENETICS TRUST (GEM APPEAL) Report of the Trustees for the year ended 31 December 2025 The Trustees present th￿r report and financial stslaments for the year ended 31 December 2025. The charity is registered. No. 1041KJ83, wth the ChaTity Commission in England and Wales. Objectives and activitles for the public beneflt The Gem Appeal was estatAished in 1994 with the Fmjrwse of provlding relief to children and young peoFAe suffering metabolic disease. The charity's governing document is its deed dated 8 August 1994 which gives the trustees the power to apply the funds in such a manner as they think fil for the benefit of any charitable objective or purpose. Thè aim of the charity is to fund research and supp)rt at the Manchester Children's Hospital and as such the charity does not make grants lo peok4e or ￿anisatIOnS whom apply speculatively. To meet this aim thè charity hosts a number of charitatde fundraising events throughrnjt ihe year. The trustees confirm that they have referred to the guidance contained in the Charity Commission's geller￿ guidance ¢)n public benefit when reviewng the charity's aims and objectives, in planning fLrture activities and setting the wliciesfor the year. Structure, governance and managemenl The charity deed r￿4 wovides for a minimum of S and a maximum of 11 trustees. Where there is a requirement for new trustees, these would be identified and appointed by the rem8ining trustees. The trustees used the Powers of Amendment in Section 6 of the Trust Deed to vary the maximum number of trustees to 11. The chair of the trustees is responsible for the induction of any new trustee. This inv olves awareness of a trustee's responsibilities, the governing document, administrative procedur8s, the history and philosophlcal appr08ch of Ihe charily. Achievements and perfom)ance DurirwJ the year the charity h8s generated funds of £43.11212024 £107,806). Total costs in generating these funds amount￿ to £65,40812024 - £89,613) resulting in a deficit of £22.296 12024- surplLL% of £18, 1931. The chaTty has been able to continue its support of the Manchester Children'5 Hospital. The SU￿ort of M8nGhesler Children's Hospital r￿aInS the focus of the ongoing w(Kk of trustees. RMCH GENETICS TRUST {GEM APPEAL) Report of the Trustees for the year ended 31 December 2025 Icontinuedl Reserves Policy The trustees aim to secure sufficient regular income and a reserve balance to be able lo meet its objectivès. Financial risk management objectives and policies The Charity makes little use of fina￿181 instruments other than operational bank accounts with reputable banks, so its èxposur8 lo pri¢e risk, credit risk. liquidity risk and Gash flow risk is not material for the assessment of the assets, liabilities. fin￿¢181 position and net movement of funds of the charity. Plans for the fuiurè The trustees are committedto continue providing suppc*t to the Manchester Children's Hospital and in particular placing emphasis on providing lurther donations for new capital expendilure and vitsl research lo the Willink UniL Statement of Trustees. r8sponsibilities Law applicable lo charities in England and Wales requires the trustees to prepare financi statements foi each fin8ncial year which give a true and fair view of the charity's fin8ncial activities during the year and of its financial position al tIE end of the year. Irb prepariro financial slalemenls giving a Irue and fair view, the trustees slKKJld follow best practiceand- sel8¢1 suitable accounting policies and then apply them consistently- makejudgements and estimates that are reasi￿able and prudent-, st8t8 whether appliCa￿e accounting standards and statements of recommended practice have been followed, subject to any rnalerial departure disclos￿ and explained in thè financial statements,. and prep8r6 thè financial statements on the going concern basis unless il 1$ inapprotKiate to presume that the charity wll continue in operation. The ITUStees are responsible for ke￿ng accounting records which disclose with reasonable accuracy the financial posrtion of the chaTily. which enable them to ascertain the financial position Df the charity, and which enable them lo ensure that the financial statements comply with the Charities Act 2011 and the Charity (Accounts and Rèportsl R8gu18tion$ 2(X)8. They are also responsible for safeguarding the assets of the charity and hence for taking reasonable slep5 for the preventic￿ and detection of fraud and breaches of law and regulations. RMCH GENEfics TRUST (GEM APPEAL) Roport of the Trustee8 for tha year ended 31 Decomber 2025 (contlnu8d) The trus￿ ¥8 resp0Th81tle for the m8intsrwKe intg3rity d thg owale and firrancial inf(Jrmation Incl￿ ￿ the chartty's websilg. L￿J151311(￿ in the Urrited Kingdom goveming the preparation and dissemination of finarLial statements may drftw from legislatic￿ in other Surisdlctlorts. By order of th• Board of Trustoos K Johnson Dats: 01.0&2026 RMCH GENEfics TRUST IGEMAPPEAL) Independent Examin•Vs rèportto the Tnrstè•s ot RMCH GENEfics TRiIST (GEM APPEALI . 31 1)xemlx¥ XQS. RO$￿A$1b1rI¢IQs ba%s vfrwt Al ts (**I1￿$trUStets.yoU9lèIes￿Y6frIe1utho knoc¢ord0￿8 20118AW￿ in ¢aryife4yAmy ￿￿￿r¢tOry. I ￿¢1£41￿￿&y al 4)¢4K** DI￿1 I havé acrn55rt0 other matters In Co￿￿£110nWrththe e¥aminathn to whlth attentiorb bo in this report hi orderto emble • ¢woper wder5tarthE Ot accow*s to be w¢ i./ /L) 2 Heap &idg0 OLY 7HR RMCH GENETICS TRUST (GEM APPEAL) Statement of Financial Activitie5 for the year ended 31 December 2025 Notès Total Funds 2025 Total Funds 2024 Incoming resources In¢omlng resources from generated funds- Voluntsry income Activities for generoling funds 6,910 36,202 4,639 103,167 Total incomlng resources 43,112 107,806 Resources expended GL)St of actlvtbes generating funds Cost of generabng vol(Jntary income Charitsble 8ctivits.es Governance costs 11,473 1.405 49,650 2,880 37.872 1,084 48.147 2,510 Total resources expended 65,408 89,613 Net movement in fvnds (22.296) 18.193 Fund balancès bmughl forward at 1 January 2024 76,112 57,919 Fund balances Ca￿led forward at 31 Docèmbor 2025 53,818 76,112 No 8CtivSlywas discontinued during the year ended 31 December 2025. There wé no gsins or losses Other than those rep(rted above. I the above represent unrestricledfunds. The notes on pages 8 to 11 form part of these financial statements. RMCH GENETICS TRUST {GEM APPEAL) Balance sheet at 31 D8comber 2025 Noteg 2025 2024 Current A8Sfrts Debtors Cash at b8nk 313 56.383 313 78,619 56,696 78.932 Crodltors: Amounts falllng duo wlthln one 12.8801 12,820) Total assets 53.816 76,112 Fund•d by: Unr•strfct•d furbds 53.816 76.112 The finarKial statements cn pages 6 to 11 were ap[￿0ved ￿ 8Uthorised for issug by the Trustees on 01 Jun8 2tr26 K Johnson T￿￿te8 G Whltwt)rth Trusts# Th)tss 8t0 11 form part of lh8s8f1rw￿laI statements. RMCH GENETICS TRUST {GEM APPEAL) Notes forming part of the financial statements for the year ended 31 DecembÈr 2025 Accounting policies Basis of Accounting The financial statements have been prepared urKler the historical cost convention and in accordance with Accounting and Rèporting by Charities.. Statement of Recommended Practice applicable lo charities preparing accounts in acGgrdance with the Financial Reporting Standard ap￿iCable in the UK IFRS1021 (effective 1 January 2015). The wncipal accounting policies a(lopled in the weparation of the financi slatemenls are sel out below. Incoming Resources All incorning re5wrces are recognised Dnce the charity has entitlement to the resources, it is cèrtain that Ihe resources will be received and thè monetary value of incoming resources can be measured with sufficiènt rdiability. Income from don81ions and other similar 1r￿O￿lng resources are included in the year in ￿1¢h they are receivable. Donations Donations arè ￿CCAlntéd for when apwoved for payment by th8 liustees. Resources expended Liabilities are recognised as expended as soon as there is a leg81 or constructive obligation committing the charity lo the expenditUTe. ￿7 expenditure is accounted for on an accru81s bas15 and has been ¢lassified uThler headings that aggregate 811 costs rel*èd to that catègory. The costs of generating funds In relatlon to charitable activities include all those resources incurred by the charity in undertaking ils work to meet those charitable a¢tivilies. SLJGh ¢osls include the direcl costs of the charitable activitytogelher with those SUPPDrt costs incurred lo enable those activities to bè undertaken. Governance costs incluée the costs of arrangements which relate to the gèneral running of the rh8rily as opposed to the direct management functions inhérent in generating funds. RMCH GENETICS TRUST (GEM APPEAL) Notes forming part of the financial statements for the year ended 31 De¢emb8r 2025 Fund accounting Unreslrict8dfunds are available for use al the discretion of the tr￿qtaeS in furtheranceof the general obj8Gliv8s of the charity. Reslrictedfunds are funds sut4.ect to specific restriclivecondilions imwswl by donors. The permrtted use of the restricted funds is set out in the notes to the financial slal8menls. Voluntary labour The charity benefits from the many hours of voluntary labour donated by its supporters in r&l81ion to fundraising and administralion. The value of these g¢xds has not been evaluated. Voluntary Income 2025 2024 Donauons and gifts 6.910 4.639 A¢tlvltles for generating funds 2025 2024 Event fundraising 36.202 103.167 RMCH GENETICS TRUST IGEMAPPEALI 4 TrA4lT•xoufw5 •XFM of4lkn¢ktlon AdvM•g lor ¢harhaW• 13ovÉrniThr• Totsl 2Q24 2025 Costs dlr•ctyallocat•d th •￿¥￿*6 Costlof (¥g6ni?Ing e¥ert6 Prornoihx41 r* 11A73 1AOS 11hn 1,405 37,￿2 Clr Chlldmrfl Ho%￿￿1 Band 6 He4lL*¢aro Sdentst 49. 49Mg) 4&147 IndependeAt4¥*minerfs 1.8 I￿10 Tot*l 12,17¥ 49.650 aY,O13 10 RMCH GENETICS TRUST (GEM APPEAL) Not85 forming part of the financial statem&nts for the year ended 31 DecÈmbÈr 2025 Trustee remuneration Trnslees received w remuneration (2024- £Nill. Debtors 2025 2024 Fundraising debtors Prepayments 313 313 313 313 Creditors: amounts falling due within one year 2025 2024 A¢¢ruals and deferred income Trade creditors 2,880 2,640 180 2,880 2,820 Trustees Indemnity insurance The chttity does not P8y any indemnity insurance behalf of the trustees. Contingent liabilities Thère are no contingent liabilities of 8 materia amount for wlich provision ha5 ￿1 been made in the financial statements. 11 Capital commitrnents There were no capital commitments at 31 December 202512024 - £Nill. 12 Ultimate controlling party The charity's ullimatecontrolling party is its board gf trustees. 11 RMCH GENEfics TRUST {GEM APPEAL) Independent Examinerfs IEport to the Trustees of RMCH GENEfics TRusr (GEM APPE4L) . 31 D￿k￿ a)25. R¢spon%Thli itie5 and ba&s of repcrt 5 ts cTrwiVs tntstees,you are respo￿￿le fcAth6 rxeparalj￿ oftlE acccuts in accordance the rW4iur￿n￿ts dthe Chariti￿* kt2011 (theAct). I report in respectof my exarnirHti￿ d thc T￿l￿t'S KcountCarri￿ ¢xft thmler Secti￿ 145 of the 2011 Act aAI in orying CAft my exaninabM. I h3ve fc4lfftd all ts all ttE aptlicable Threcti( given ty CrniSSiOnLtsxler Secti￿ 14qS)(b) of Ike ACL l kne e(YrfJleted rnyexaminatiCWL I c¢xffirm ttHt no m&erial rnatt￿s have ¢fxne to my atteftioft Ile recuds we rx* ift xwdarte with section 130 of the QRrities the acc{Xh￿ did rKX q¥liGalAe requireh&yrs e4y*enung f(*m a￿1 cortsidefed &% pwt of an indepetht etrninati I have rK> afxl have come across Tr) other matters In connectx>n with the examinatk>n to which atte￿0￿ slM>uld be drnwn in report in order to enable a proper uftderstaDdry of the accowts to be wc /L) RAA fhompsth Jones Business SdutiLknS Lithited 2 Heap Bridge Bury BL9 711R Dat￿ 01.062tr26