2022-12-31-accounts

Annual Report The GEM Appeal Charity Number 1040083

20 April 2023

Annual report for the year 01/01/2022 – 31/12/2022 The Royal Manchester Childrens Hospital Genetic Trust (GEM Appeal) is constituted by Deed of Trust and is a registered charity, number 1040083. Its address is 6 Yealand Close, Bamford, Rochdale. OL11 4DL. The charity trustees at the start and end of the year were as follows:

Mrs Karen Johnson (Chairperson) Mrs Katie Duxbury (Vice Chairperson) Mr Garry Whitworth (Treasurer) Mrs Wendy Mills (Secretary) Mr Peter Johnson Mrs Joy Whitworth Mr David Howles Mrs Lynn Howles Mrs Judith Paraschack Mr Robert Rawsthorne Mr Mario Burian

As usual our AGM was held in January (2023) and reviewed the previous year’s activity.

This was the first “full” year where covid restrictions were not in force and limit our ability to arrange functions on a face to face basis. It was however recognised that even though restrictions had been limited people were not supporting us in the same numbers ad before at the “live” events and therefore meant that our income was down a little on the year 2021.

That said the events did provide a much needed outlet for many people and did continue to raise funds for the charity and we managed to arrange the following annual events:

10k Sponsored Walk The Strawberry Sparkle Ladies Lunch The Annual Winter Ball hosted by Denise Welch The Welders Ball The Christmas Afternoon Tea.

We also managed to arrange another Ladies Fashion Show which this year was by Fizz Fashions.

We did as we said we would in the annual report for 2021 and concentrated on the above events, avoiding clashes with other charity events and getting as much support as possible for out annual tried and tested events. We had to find a new venue for our Strawberry Sparkle and are pleased to say that we were

welcomed and looked after by our local golf club, Rochdale Golf club and wish to thank them for their hospitality and look forward to working with them in 2023. The golf club also provided the setting for the Fizz Fashion Show. Lloyds Bank also provided another small sponsorship package for our annual winter ball but have told us that due to changes this will not be a possibility for the 2023 ball and advised us to try to find somebody else to help with sponsorship.

The monies we had in the account during 2022 were used to fund the scientist for the Willink Unit and we donated over £66k to the unit to fund an 18 months contract for the scientist who will look to further utilise equipment (Tandem Mass Spectrometer) purchased by The GEM Appeal and do research to find new diagnostic tests as well as other treatments and cures. The scientist actually started work at the unit in January 2023.

The unit has asked if we could look at raising further funds to extend the contract of the scientist to 24 months, which we are happy to do.

The aims of the charity again remain the same and are as follows: Funding to provide research into incurable genetic diseases and potential cures Provision of equipment to improve treatment and help with the above.

All of our trustees wished to remain in post and the same officers as in 2022 were voted in for 2023.

The AGM finished by again acknowledging the time donated by the trustees and associates and how much value this added to the charity and how it enabled the charity to continue raising the funds it does.

i) thompson Jones Business Solutions Limited RMCH GENEncs TRUST (GEM APPEAL) FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2022 R•glstsr•d Charlty Numb•r: 1040083 Thompson Jon•s Bu$ln•ss 8olutlons Limlt•d Chart•T•d Acoountants 2 Hmp Br*• Bury BL9 7HR

RMCH GENETICS TRUST (GEM APPEAL) Annual Report and Flnanclal SL9temonts for th• y•ar onded 31 Decomb•r 2022 Cont•nts Page.. 24 Report of the Trustees &6 Independent Examiner's Report Statement of Financial Activrties Balance Sheet 9-12 Notes foming part of the financial statements Trusts•s Mrs Kar•n Johnson Mrs Lynn Howl•$ PAr Garry Whllworth Mr P•t•r Johnson Mrs Joy Whltworth Ilr David Howlos Mr Robort Rawsthorn• Mrs Judlth Paras¢ha¢k IATS WMdy MIH• Mr Marfo Burlan Alrs Kat1• Duxbury Chalr S•¢r•tary Tr•asuror Trust Trust•• Trust•0 Trust•• Tru$t•• TNst•• Trust•• Trust•0 Contact addr•$* 53 Waingap Rise, Rochdale. OL12 9UB R•gl$t•r•d charfty numb•r 1040083 A¢countants and Ind•p•nd•nt Examln•rs Thompson Jones Business Solutions Limited, 2 Heap Bridge, Bury, BL9 7HR Bank•rs Uoyds Bank, Salford Shopping Centre, 1(k12 Han￿'n$0￿ Way, Salford, M6 5JA

RMCH GENEfics TRUST (GEM APPEAL) Report of th• Trustws for th• y•ar end•d 31 Decembgr 2022 The Trustees present their report and financial ststements ts th8 y8ar ended 31 DecemtEr 2022. The Charity is r8gistered. No. 1040083. with the Charity Commission in England and Wales. Obj•¢lives and actlvltles for the publlc benefft Th8 Gem Appeal was estab￿ed in 1994 wth the WTPOS8 of provithng rBfief lo childrèn and young people Suffering metabolic dtsease. The chartiy's governing document is its deed dated 8 August 1994 which gives the trustees the power to apply the fifflds in such a manner as they think fft for the b￿efft of ary charitable obiethe or purpose. The aim of the tharity is to I￿K1 researth and suprth at the Manthester Children's whom appty sP￿la￿'V￿y. To meet this aim the charty hosts a number of charital)le fundraising 8vents throughoLrt with celebnty patrons. The trustees ¢onfimi that they have referred to the guidance contained in the Chanty and objectives, in planning future aclivrties and sethng the policies for the year. struG￿re, gov•rnance and managthn•nt The charity deed ncrw Fyovths for a minimum of 5 and a maximum of 11 tru*ees. Wthere there is a requirement nthv trustees, these be Klentified and appointed Ihe Trust Deed to vary the maximum numter of lJuste8S to 11. The chair of the tfustaes is responsible for the irKludion of any new trustee. This involves awarenéss of a trustee's resportsibtllt￿5. the govemiThJ document, administrative procedu￿, the history and ￿lI050phical approach of the thanty. Achlevem•nts and prforman Dufing the year the charity has generated funds of £65,889 (2021 - £89,740). Total costs in generati￿ thes8 funds amounted to £35.803 (￿21 . £29,715) resufting in a surplus prior to charitable expenditure of £30.085 (2021- £40.0251. The charity has been able to continue its SUFWt of the mand￿ster Children's HOs￿tal and this year afE delohted to report a donation of £66,384 to acqui￿ the s8rvices of a Band 6 Healthcare Soentist to Contin￿ to help with the diagnosis of genetic diseases. Hospital. The supp(xt of Manchester Chldren's Hosytsl ￿MaInS the focus of the on90ing work of trustees.

RMCH GENETICS TRUST IGEM APPEAL) R•port ol th• Trustms for th• y•ir •ndod 31 D•¢•mb•r 2022 (contlnu•d) The trustees aim to secure sufficierrt regular income a reserve balan￿ to be able to meet its objeLtwe5. Financlal rlsk manag•m•nt oblectives and pollcles The charity makes littk use of financial instruments (rther than operational bank accounts with rewtatAe banks, so its exposure to price risk. credit r￿. liquidity risk and position and net movement of funds of the charity. Plans for th• future The trustees are committed to Contin￿ providing support to the Manchestsr Chiklren's Hosp'tal and in particular plaong emphasis on provKling further donab"(Th for new capTtal exp8rKliture and vital research lo the Wllink Unil. Stat•ment of Trusteos, rosponsibiliti•s Law applicabl8 to chal￿eS in ErvJkqnd and Wales requires trustees to prep¥e financial statements for each financial year which give a true aThJ fair vTrew of the chatty's fman¢ial activrties during the year ar¥J of ts fu)ancHI poSi￿n at the énd of the year. In preparing fr￿ncIal statemerts givbng a true and fair v￿, the trustees shoukl follow best practice and.. select suitable accounting pofThs and than ar4)ly them corristently; make judgements and estimates that are reasonable arKI pr￿jent", state whether applicatAe accounting starKlards aThJ statements of recommended pradice have been followed. subject to any material departure prepare the financial statements oft the goirvj conwn basis unless it is inaptryrie to PTe5um8 that the thity will contsnue in operation. The trustees are reSpC￿51b1e for keepirKJ a¢countiNJ records which drsclose with aS￿rtain the financial positson of the charity. arKI which enable them to ensure that the financial statements comply with the Charrties Act 2011 arKI the Chanty {Accounts and the charity and hence for tsking reasonable steps for the prevention amd detection of fraud and breaC￿￿S of law and regulaticK)s.

RMCH GENETICS TRUST (GEM APPEAL) Report ol th• Trustoes for th• y•ar •nd•d 31 Decomb•r 2022 Icontlnu•d) The trustees are responsible for the maintenanc4 arKI integrity of the COryK)rate and financial infomiation induded on the Charity's websrte. Legislation in the United differ from legislation in other jurisd￿11<>nS. By ¢>rd•r K Johnson Chairp•rson

RMCH GENEncs TRUST (GEM APPEAL) Ind•p•nd•nt Examln•fs r•port to th• Trustms Of RMCH GENETICS TRUST IGEM APPEAL l ￿port on the accounts of RMCH Genetics Trust (GEM Appeal) on pages 7 to 12 for the year ended 31 December 2022. This report is made solety to the charty's trustees, as a body in accordance with that I M￿ht state to the charity's tNstees those matter51 am required to state to them in an independent examinerfs ￿port and for no other purpose. To the fullest extent pemiitted by law. I do not accept respwbiknty to anyoré othw than the charrty and its trustees as a body, for my examination work. for this report. or for the opinions I have fomied. R•sp•ctlv• rn8ponslbllltl•s of th• tru•t••s and Ind•p•nd•nt •xamln•r The trustees are resF#)nsible for the preparation of the accounts. The tNst8es consider thal an a￿Sit is rwA teqwed lor IIMS yw under sth 144 of the ChaIrt￿S Act 2011 (the 2011 Acl) and that an independent examination ts needed. l am qualffied to Accountsnts in England and Wales (ICAEW). It is my resF)onsibilty to: examine the accounts under s•ction 145 of the 2011 Act., to folkm the procedures laid down in the General Directions given by the Charlty Commiss•on under se(lion 145(51(b) of the 2011 Act: and to state whether parn'cular matters have come to my attention. Bash of •xamlnatlon My examination was caffied out in accordance with General Directions given by the Chartty Commission. An examination indudes a review of the accourrting records kept by the tharity and a comparison of the accounts presented wth thc6e records. It also includes consideration of any unusual ftems of dtsclosure in the accounts and seeking explanations from you as tntstees conceming any such matters. procedures undertaken do not F¥OVMJe au the evidence thal would ts re￿￿ in an audrt a) consequently no op.nion is given as to whether accounts present 'a true and fair view, and the report is limited lo th(￿e matt&5 set out in the statement below.

RAICH GENETICS TRUST (GEPA APPEAL) Ind•p•ndent Examln•fs r•port to th• Trustees of RMCH GENETICS TRUST (GEM Inde￿ndOnt gxamln•fs stat•m•nt In the course of my examination. no matter has com8 to my attent￿n. which gives me reasonable cause to believe that, in any material respect, the to keep proper accounty reconts in accordanc8 with secti(Jn 130 of the 2011 the accounting requirements of the 2011 Aci not been met,. or understanding of the accounts to be reached. The data for the year ended 31 t)ecember 2020 was not subj.ect to Independent examination or audit. Carl Urniston (ACAI 2 H•ap Brldg• Bury Lan¢4shlv• BL9 7HR ( L/.CYl..21

RMCH GENETICS TRUST (GEM APPEAL stat•m•nt of Flnan¢lal A¢llvltl•s th• y•ar •nd•d 31 D•c•mbor 2022 Totsl Funds 2022 Total Funds Inoomlw r•sourB•s Inoamlng r•SoUr￿$ from g•n•rat•d funds: Voluntary ineom6 Activrtw Yor generaling ffijnds 5,173 64,567 Tatal In¢omkng r•￿u￿•S R•s•ur¢•s •xwd•d Cost of a¢tivltles generating funds Cost of generab'ng voluntary NK4Jrne Charli able ￿t￿lI Governance costs 33,332 29.535 110,803 180 2.410 102 187 140518 N•1 mov•m•nt In fvnds 136,2991 170,7781 Fund balances brtyJght foThrnrd al 1 January 2022 Fund balan¢•s ￿rI1•d f•rwanl No ￿t￿lty was diso)nts'nued during year ended 31 December 2022. l the atthe represenl UTh￿tr￿ted funds. The notes on pw 9 to 12 form pwt of I￿se financid Staten￿ts.

RMCH GENEfics TRUST (GEM APPEAL) Balan￿ sh••t at 31 December 2022 2022 2021 Curr•nt Ass•ts DeLrto Cash at bank 29.036 20.836 86.071 49.872 86,071 Cr•dlltys: Amounts hlllng du• wlthln on• y•*r (2.4401 12,3401 Totsl •ss•ts Unr•strlotsd funds 83.731 The financial Ststements on pages 7 to 12 were approved auihortsed for issue by the TruBt8es on ..1 Trusts• The notes on page 9 10 12 fom wi ofthese fwn¢ial slater￿nts.

RMCH GENETICS TRUST (GEM APPEAL) Not•s forniinq part of th• fina￿1•1 st•t•m•nts br th• y••r •nd•d 31 D•a•mb•r 2022 Bas15 01 Aooountlng The financial state￿nts havo baen prepar&J under Ihe hlstorral cost (Thvenlion and in accordan￿ wfth Ato>Jnting aThJ ReFQrting ty Charrtitis.. Ststem&nt of Recommended Practice 8Pt4uble lo charities preparing ￿)Unts in accordan¢e the Re(￿ Slandwd awArabl& In th6 UK IFRS1021I8￿lW8 1 January 20151. The principal ac£ounling polw awed in Ihe weparation of the financ statements are Set out bekMI. Inoornlnq R•souro•s PJI Incg)ming resources are recojnised once Ihe charity has 8ntltknont to the incoming resources can be ￿Sured with sufftient reliabilty. Incorr from donations and other SI￿￿1¥ inc4)ming resources aro [r￿luded in th8 year in which they are recfjivab￿. Donations are accounknj for whon approved for payment by the tnJste•s. L￿￿￿11￿ are recJ)gnised as exwmled as s￿n as there is a legal or rxjnstructive on an accruals basis and has boon Classrf￿d under headings that aggregate am costs related lo that eat¢gory. Th& costs of generating fvnds in f8latk)n lo tharilatle aCtfvtt￿ Include alf Ihose resourc8s incurred by the charity in undertaking tts to meet those charitable activities. Such costs include the direct costs of the charitable activity Ic•Jether with Governance costs indude the costs of 8rrangerr£nts Wh￿ relate lo the general running of the charity as oprKAed to the direct ￿%?nagernent fiJncb"orv8 inherent In g￿erating funds.

RMCH GENETICS TRUST IGEM APPEAL) Not•s formlng part of Ihe finanol#l st*l•m•nts for th• year end•d 31 D•o•mb•r 2022 Fund a¢Munting Un[eStr￿ted funds are 8vailabKg for use at the discretion of the trustees In furtheran Restrlctod funds are funds subject to sp8Gifi¢ reStr￿ts¥e conditsons imposed by donors. Th6 permitted usa of the iestricted funds is sei out in the Th)tes to the ststements. Voluntsry IAbour The charity benefits from the many hours of voluntary labour donated by its supporters In relation to fundraistng and administration. Th8 value of th9$& goods has not been evaluated. V•luntsry InGom• 2022 2021 Donatbns and gifts 2022 2021 Evènt fundraisino 10

RMCH GENETICS TRUST (GEM APPEAL> Not•8 fornilng part of the fin•ncial Statements for the year ended 31 December 2022 Icontlnued) 4 Total re8our¢e8 expend•d B•#l$ ol allocatlon Adiviti•s for gen•r•llng funds Charftabl• Governanc• a¢tlvitles Totsl 2022 Total 2021 Cost• dlreclty alk)catsd to acllvltle• Costs of organising events Promotional adivities Direct Dirert 33,332 29.535 Charltsbl• Adivitl•8 Direct - Donabon to Manchfjster Children s Hosptal for Band 6 Healthcare Scientist 86.384 66.384 110.803 Support co•ts allo¢•l•d to activSti•s Independent e¥affiner'$ remunerab'on Oirect 2,410 2.410 180 Totsl 394 11

RMCH GENEncs TRUST (GEM APPEAL) Notes foThiing part ol th• flMn¢lal stal•m¢Dts for th• ymr •nd•d 31 D•6•mb•r 2022 Trustees reCep￿d no remuneration {2021- £Nil). 2022 2021 FurKlral￿ng debtor5 year. Cr•dilm: amounts falling du• wlthin one ymr 2022 2021 Accrua15 and deferred income The charity does Th)t pay any indemnity insurartce on behalf ofthe trustees. 10 Conllng•nt liabillll•s There are no contingent liabilities of a material amount for which pr￿l$K)n has not been made in the financ￿1 stalemnts. 11 Cawtsl commlkn•nts There there no (8iNtal commi1n￿ts at 31 D￿fflber 2022 {2021- £Nil}. 12 Uftimat• controllkng party The charity's ultiffAte controlling party is tts tthrd of tnjstees. 12

i) thompson Jones Business Solutions Limited RMCH GENEncs TRUST (GEM APPEAL) FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 DECEMBER 2022 R•glstsr•d Charlty Numb•r: 1040083 Thompson Jon•s Bu$ln•ss 8olutlons Limlt•d Chart•T•d Acoountants 2 Hmp Br*• Bury BL9 7HR

RMCH GENETICS TRUST (GEM APPEAL) Annual Report and Flnanclal SL9temonts for th• y•ar onded 31 Decomb•r 2022 Cont•nts Page.. 24 Report of the Trustees &6 Independent Examiner's Report Statement of Financial Activrties Balance Sheet 9-12 Notes foming part of the financial statements Trusts•s Mrs Kar•n Johnson Mrs Lynn Howl•$ PAr Garry Whllworth Mr P•t•r Johnson Mrs Joy Whltworth Ilr David Howlos Mr Robort Rawsthorn• Mrs Judlth Paras¢ha¢k IATS WMdy MIH• Mr Marfo Burlan Alrs Kat1• Duxbury Chalr S•¢r•tary Tr•asuror Trust Trust•• Trust•0 Trust•• Tru$t•• TNst•• Trust•• Trust•0 Contact addr•$* 53 Waingap Rise, Rochdale. OL12 9UB R•gl$t•r•d charfty numb•r 1040083 A¢countants and Ind•p•nd•nt Examln•rs Thompson Jones Business Solutions Limited, 2 Heap Bridge, Bury, BL9 7HR Bank•rs Uoyds Bank, Salford Shopping Centre, 1(k12 Han￿'n$0￿ Way, Salford, M6 5JA

RMCH GENEfics TRUST (GEM APPEAL) Report of th• Trustws for th• y•ar end•d 31 Decembgr 2022 The Trustees present their report and financial ststements ts th8 y8ar ended 31 DecemtEr 2022. The Charity is r8gistered. No. 1040083. with the Charity Commission in England and Wales. Obj•¢lives and actlvltles for the publlc benefft Th8 Gem Appeal was estab￿ed in 1994 wth the WTPOS8 of provithng rBfief lo childrèn and young people Suffering metabolic dtsease. The chartiy's governing document is its deed dated 8 August 1994 which gives the trustees the power to apply the fifflds in such a manner as they think fft for the b￿efft of ary charitable obiethe or purpose. The aim of the tharity is to I￿K1 researth and suprth at the Manthester Children's whom appty sP￿la￿'V￿y. To meet this aim the charty hosts a number of charital)le fundraising 8vents throughoLrt with celebnty patrons. The trustees ¢onfimi that they have referred to the guidance contained in the Chanty and objectives, in planning future aclivrties and sethng the policies for the year. struG￿re, gov•rnance and managthn•nt The charity deed ncrw Fyovths for a minimum of 5 and a maximum of 11 tru*ees. Wthere there is a requirement nthv trustees, these be Klentified and appointed Ihe Trust Deed to vary the maximum numter of lJuste8S to 11. The chair of the tfustaes is responsible for the irKludion of any new trustee. This involves awarenéss of a trustee's resportsibtllt￿5. the govemiThJ document, administrative procedu￿, the history and ￿lI050phical approach of the thanty. Achlevem•nts and prforman Dufing the year the charity has generated funds of £65,889 (2021 - £89,740). Total costs in generati￿ thes8 funds amounted to £35.803 (￿21 . £29,715) resufting in a surplus prior to charitable expenditure of £30.085 (2021- £40.0251. The charity has been able to continue its SUFWt of the mand￿ster Children's HOs￿tal and this year afE delohted to report a donation of £66,384 to acqui￿ the s8rvices of a Band 6 Healthcare Soentist to Contin￿ to help with the diagnosis of genetic diseases. Hospital. The supp(xt of Manchester Chldren's Hosytsl ￿MaInS the focus of the on90ing work of trustees.

RMCH GENETICS TRUST IGEM APPEAL) R•port ol th• Trustms for th• y•ir •ndod 31 D•¢•mb•r 2022 (contlnu•d) The trustees aim to secure sufficierrt regular income a reserve balan￿ to be able to meet its objeLtwe5. Financlal rlsk manag•m•nt oblectives and pollcles The charity makes littk use of financial instruments (rther than operational bank accounts with rewtatAe banks, so its exposure to price risk. credit r￿. liquidity risk and position and net movement of funds of the charity. Plans for th• future The trustees are committed to Contin￿ providing support to the Manchestsr Chiklren's Hosp'tal and in particular plaong emphasis on provKling further donab"(Th for new capTtal exp8rKliture and vital research lo the Wllink Unil. Stat•ment of Trusteos, rosponsibiliti•s Law applicabl8 to chal￿eS in ErvJkqnd and Wales requires trustees to prep¥e financial statements for each financial year which give a true aThJ fair vTrew of the chatty's fman¢ial activrties during the year ar¥J of ts fu)ancHI poSi￿n at the énd of the year. In preparing fr￿ncIal statemerts givbng a true and fair v￿, the trustees shoukl follow best practice and.. select suitable accounting pofThs and than ar4)ly them corristently; make judgements and estimates that are reasonable arKI pr￿jent", state whether applicatAe accounting starKlards aThJ statements of recommended pradice have been followed. subject to any material departure prepare the financial statements oft the goirvj conwn basis unless it is inaptryrie to PTe5um8 that the thity will contsnue in operation. The trustees are reSpC￿51b1e for keepirKJ a¢countiNJ records which drsclose with aS￿rtain the financial positson of the charity. arKI which enable them to ensure that the financial statements comply with the Charrties Act 2011 arKI the Chanty {Accounts and the charity and hence for tsking reasonable steps for the prevention amd detection of fraud and breaC￿￿S of law and regulaticK)s.

RMCH GENETICS TRUST (GEM APPEAL) Report ol th• Trustoes for th• y•ar •nd•d 31 Decomb•r 2022 Icontlnu•d) The trustees are responsible for the maintenanc4 arKI integrity of the COryK)rate and financial infomiation induded on the Charity's websrte. Legislation in the United differ from legislation in other jurisd￿11<>nS. By ¢>rd•r K Johnson Chairp•rson

RMCH GENEncs TRUST (GEM APPEAL) Ind•p•nd•nt Examln•fs r•port to th• Trustms Of RMCH GENETICS TRUST IGEM APPEAL l ￿port on the accounts of RMCH Genetics Trust (GEM Appeal) on pages 7 to 12 for the year ended 31 December 2022. This report is made solety to the charty's trustees, as a body in accordance with that I M￿ht state to the charity's tNstees those matter51 am required to state to them in an independent examinerfs ￿port and for no other purpose. To the fullest extent pemiitted by law. I do not accept respwbiknty to anyoré othw than the charrty and its trustees as a body, for my examination work. for this report. or for the opinions I have fomied. R•sp•ctlv• rn8ponslbllltl•s of th• tru•t••s and Ind•p•nd•nt •xamln•r The trustees are resF#)nsible for the preparation of the accounts. The tNst8es consider thal an a￿Sit is rwA teqwed lor IIMS yw under sth 144 of the ChaIrt￿S Act 2011 (the 2011 Acl) and that an independent examination ts needed. l am qualffied to Accountsnts in England and Wales (ICAEW). It is my resF)onsibilty to: examine the accounts under s•ction 145 of the 2011 Act., to folkm the procedures laid down in the General Directions given by the Charlty Commiss•on under se(lion 145(51(b) of the 2011 Act: and to state whether parn'cular matters have come to my attention. Bash of •xamlnatlon My examination was caffied out in accordance with General Directions given by the Chartty Commission. An examination indudes a review of the accourrting records kept by the tharity and a comparison of the accounts presented wth thc6e records. It also includes consideration of any unusual ftems of dtsclosure in the accounts and seeking explanations from you as tntstees conceming any such matters. procedures undertaken do not F¥OVMJe au the evidence thal would ts re￿￿ in an audrt a) consequently no op.nion is given as to whether accounts present 'a true and fair view, and the report is limited lo th(￿e matt&5 set out in the statement below.

RAICH GENETICS TRUST (GEPA APPEAL) Ind•p•ndent Examln•fs r•port to th• Trustees of RMCH GENETICS TRUST (GEM Inde￿ndOnt gxamln•fs stat•m•nt In the course of my examination. no matter has com8 to my attent￿n. which gives me reasonable cause to believe that, in any material respect, the to keep proper accounty reconts in accordanc8 with secti(Jn 130 of the 2011 the accounting requirements of the 2011 Aci not been met,. or understanding of the accounts to be reached. The data for the year ended 31 t)ecember 2020 was not subj.ect to Independent examination or audit. Carl Urniston (ACAI 2 H•ap Brldg• Bury Lan¢4shlv• BL9 7HR ( L/.CYl..21

RMCH GENETICS TRUST (GEM APPEAL stat•m•nt of Flnan¢lal A¢llvltl•s th• y•ar •nd•d 31 D•c•mbor 2022 Totsl Funds 2022 Total Funds Inoomlw r•sourB•s Inoamlng r•SoUr￿$ from g•n•rat•d funds: Voluntary ineom6 Activrtw Yor generaling ffijnds 5,173 64,567 Tatal In¢omkng r•￿u￿•S R•s•ur¢•s •xwd•d Cost of a¢tivltles generating funds Cost of generab'ng voluntary NK4Jrne Charli able ￿t￿lI Governance costs 33,332 29.535 110,803 180 2.410 102 187 140518 N•1 mov•m•nt In fvnds 136,2991 170,7781 Fund balances brtyJght foThrnrd al 1 January 2022 Fund balan¢•s ￿rI1•d f•rwanl No ￿t￿lty was diso)nts'nued during year ended 31 December 2022. l the atthe represenl UTh￿tr￿ted funds. The notes on pw 9 to 12 form pwt of I￿se financid Staten￿ts.

RMCH GENEfics TRUST (GEM APPEAL) Balan￿ sh••t at 31 December 2022 2022 2021 Curr•nt Ass•ts DeLrto Cash at bank 29.036 20.836 86.071 49.872 86,071 Cr•dlltys: Amounts hlllng du• wlthln on• y•*r (2.4401 12,3401 Totsl •ss•ts Unr•strlotsd funds 83.731 The financial Ststements on pages 7 to 12 were approved auihortsed for issue by the TruBt8es on ..1 Trusts• The notes on page 9 10 12 fom wi ofthese fwn¢ial slater￿nts.

RMCH GENETICS TRUST (GEM APPEAL) Not•s forniinq part of th• fina￿1•1 st•t•m•nts br th• y••r •nd•d 31 D•a•mb•r 2022 Bas15 01 Aooountlng The financial state￿nts havo baen prepar&J under Ihe hlstorral cost (Thvenlion and in accordan￿ wfth Ato>Jnting aThJ ReFQrting ty Charrtitis.. Ststem&nt of Recommended Practice 8Pt4uble lo charities preparing ￿)Unts in accordan¢e the Re(￿ Slandwd awArabl& In th6 UK IFRS1021I8￿lW8 1 January 20151. The principal ac£ounling polw awed in Ihe weparation of the financ statements are Set out bekMI. Inoornlnq R•souro•s PJI Incg)ming resources are recojnised once Ihe charity has 8ntltknont to the incoming resources can be ￿Sured with sufftient reliabilty. Incorr from donations and other SI￿￿1¥ inc4)ming resources aro [r￿luded in th8 year in which they are recfjivab￿. Donations are accounknj for whon approved for payment by the tnJste•s. L￿￿￿11￿ are recJ)gnised as exwmled as s￿n as there is a legal or rxjnstructive on an accruals basis and has boon Classrf￿d under headings that aggregate am costs related lo that eat¢gory. Th& costs of generating fvnds in f8latk)n lo tharilatle aCtfvtt￿ Include alf Ihose resourc8s incurred by the charity in undertaking tts to meet those charitable activities. Such costs include the direct costs of the charitable activity Ic•Jether with Governance costs indude the costs of 8rrangerr£nts Wh￿ relate lo the general running of the charity as oprKAed to the direct ￿%?nagernent fiJncb"orv8 inherent In g￿erating funds.

RMCH GENETICS TRUST IGEM APPEAL) Not•s formlng part of Ihe finanol#l st*l•m•nts for th• year end•d 31 D•o•mb•r 2022 Fund a¢Munting Un[eStr￿ted funds are 8vailabKg for use at the discretion of the trustees In furtheran Restrlctod funds are funds subject to sp8Gifi¢ reStr￿ts¥e conditsons imposed by donors. Th6 permitted usa of the iestricted funds is sei out in the Th)tes to the ststements. Voluntsry IAbour The charity benefits from the many hours of voluntary labour donated by its supporters In relation to fundraistng and administration. Th8 value of th9$& goods has not been evaluated. V•luntsry InGom• 2022 2021 Donatbns and gifts 2022 2021 Evènt fundraisino 10

RMCH GENETICS TRUST (GEM APPEAL> Not•8 fornilng part of the fin•ncial Statements for the year ended 31 December 2022 Icontlnued) 4 Total re8our¢e8 expend•d B•#l$ ol allocatlon Adiviti•s for gen•r•llng funds Charftabl• Governanc• a¢tlvitles Totsl 2022 Total 2021 Cost• dlreclty alk)catsd to acllvltle• Costs of organising events Promotional adivities Direct Dirert 33,332 29.535 Charltsbl• Adivitl•8 Direct - Donabon to Manchfjster Children s Hosptal for Band 6 Healthcare Scientist 86.384 66.384 110.803 Support co•ts allo¢•l•d to activSti•s Independent e¥affiner'$ remunerab'on Oirect 2,410 2.410 180 Totsl 394 11

RMCH GENEncs TRUST (GEM APPEAL) Notes foThiing part ol th• flMn¢lal stal•m¢Dts for th• ymr •nd•d 31 D•6•mb•r 2022 Trustees reCep￿d no remuneration {2021- £Nil). 2022 2021 FurKlral￿ng debtor5 year. Cr•dilm: amounts falling du• wlthin one ymr 2022 2021 Accrua15 and deferred income The charity does Th)t pay any indemnity insurartce on behalf ofthe trustees. 10 Conllng•nt liabillll•s There are no contingent liabilities of a material amount for which pr￿l$K)n has not been made in the financ￿1 stalemnts. 11 Cawtsl commlkn•nts There there no (8iNtal commi1n￿ts at 31 D￿fflber 2022 {2021- £Nil}. 12 Uftimat• controllkng party The charity's ultiffAte controlling party is tts tthrd of tnjstees. 12