**Charity registered number: 1010639** **The Society for the Study of Inborn Errors of Metabolism** **(A company limited by guarantee)** ## **Annual report and financial statements** For the year ended 31 December 2024 Company registered number: 02567711 ## **The Society for the Study of Inborn Errors of Metabolism** ## **Contents** |**ontents**|| |---|---| ||Page| |Reference and administrative details|1| |Trustees’ report|2 - 7| |Independent auditor’s report|8 - 11| |Statement of financial activities|12| |Statement of financial position|13| |Statement of cash flows|14| |Notes to the financial statements|15 - 22| **The Society for the Study of Inborn Errors of Metabolism** ## **Reference and administrative details** For the year ended 31 December 2024 **Trustees** Prof M R Baumgartner (Appointed 1 January 2025) Prof Dr D M Cassiman Dr A E Dardis Dr A Garcia-Cazorla Dr S Grünewald Prof Dr Med I M Knerr Prof G La Marca Dr R J Lapatto Dr H Michelakakis Prof P B Mills Dr E M Murphy (Appointed 30 April 2025) Prof J C Rocha Prof M Schiff **Company secretary** Dr H Michelakakis **Company registered number** 02567711 **Charity registered number** 1010639 **Registered office** C/O Stone King LLP Boundary House 91-93 Charterhouse Street London EC1M 6HR **Independent auditor** Buzzacott Audit LLP 130 Wood Street London EC2V 6DL **Bankers** Barclays Bank PLC PO Box 43 Sheffield S9 2LF 1 **The Society for the Study of Inborn Errors of Metabolism** ## **Trustees’ report** For the year ended 31 December 2024 The Trustees present their annual report together with the financial statements of The Society for the Study of Inborn Errors of Metabolism (‘SSIEM’) (‘the Society’) for the year ended 31 December 2024. Since the Society qualifies as small under section 383 of the Companies Act 2006, the Strategic report required of medium and large companies under The Companies Act 2006 (Strategic report and Directors’ report) Regulations 2013 is not required. ## **STRUCTURE, GOVERNANCE AND MANAGEMENT** ## **Constitution** The Society is constituted under a Memorandum of Association dated 12 December 1990 and amended by Resolutions dated 13 September 1991, 6 September 2007, 31 August 2011 and 3 September 2014. It is a registered charity with its charity number being 1010639. The Society is limited by guarantee and does not have share capital. All trustees are members of the Society and guarantee to contribute £1 in the event of winding up. ## **Trustees** The Trustees who served during the year were: Prof Dr D M Cassiman Dr A E Dardis Dr A Garcia-Cazorla Dr S Grünewald Prof Dr J D B Häberle (Resigned 30 April 2025) Prof Dr Med I M Knerr Prof G La Marca Dr R J Lapatto Dr H Michelakakis Prof P B. Mills Prof J C Rocha Prof M Schiff Prof S Rahman (Resigned 1 January 2025) ## **OBJECTIVES AND ACTIVITIES** ## **Policies and objectives** The principal objective of the Society is to foster the study of inherited metabolic disorders and related topics **.** In order to further these objectives, membership of the Society promotes the exchange of ideas between professional workers in different disciplines who are interested in inherited metabolic disorders. The aim is pursued in scientific meetings, training courses and publications. The Society supports an annual symposium concentrating on different topics relating to inborn errors of metabolism each year and publishes its journals (Journal of Inherited Metabolic Disease (JIMD) and JIMD reports). Membership of the Society is open to all and especially to those who are professionally involved in the study of metabolic disorders or related topics. 2 **The Society for the Study of Inborn Errors of Metabolism** ## **Trustees’ report (continued)** For the year ended 31 December 2024 ## **Public benefit** In supporting an annual symposium and publishing its journal, the Society aims to advance health by sharing ideas on different topics relating to Inborn Errors of Metabolism. In doing so, the Society has considered the Charity Commission's guidance on public benefit. ## **Organisational structure and decision-making** A General Council made up of Honorary Officers of the Society and additional members manage the organisation. The Honorary Officers are a Chair, a Secretary and a Treasurer. Council Members are elected at the Annual General Meeting. Honorary Officers are appointed by the General Council. Honorary Officers of the Society may hold office for three years and are eligible for re-appointment to the same office for a further three years. Members of the General Council other than Honorary Officers may hold office for three years; they may be re-elected for a further three years. All Directors/Trustees of the Society are considered to be key management personnel of the SSIEM although all are non-paid volunteers. Other key management personnel include the SSIEM Administration team with whom the Directors/Trustees work closely with. The Finance Sub-Committee (‘FSC’) comprises the current Honorary Treasurer, Honorary Chair, Honorary Secretary, Chair and Secretary Elect if applicable, previous Honorary Treasurer and an independent financial advisor plus invited members of staff. ## **Trustees' responsibilities statement** The Trustees (who are also directors of The Society for the Study of Inborn Errors of Metabolism for the purposes of company law) are responsible for preparing the trustees' report and the financial statements in accordance with applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice). Company law requires the trustees to prepare financial statements for each financial year. Under company law the trustees must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the Society and of the incoming resources and application of resources, including the income and expenditure, of the Society for that period. In preparing these financial statements, the trustees are required to: - select suitable accounting policies and then apply them consistently; - observe the methods and principles in Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with ‘the Financial Reporting Standard applicable to the UK and Republic of Ireland’ (‘FRS 102’); - make judgements and accounting estimates that are reasonable and prudent; - state whether applicable United Kingdom Accounting Standards have been followed, subject to any material departures disclosed and explained in the financial statements; and - prepare the financial statements on the going concern basis unless it is inappropriate to presume that the Society will continue in operation. 3 **The Society for the Study of Inborn Errors of Metabolism** ## **Trustees’ report (continued)** For the year ended 31 December 2024 The Trustees are responsible for keeping adequate accounting records that are sufficient to show and explain the Society's transactions and disclose with reasonable accuracy at any time the financial position of the Society and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the Society and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities. The Trustees are responsible for the maintenance and integrity of the corporate and financial information included on the Society’s website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions. ## **ACHIEVEMENTS AND PERFORMANCE** ## **Review of activities** The new three-tier membership subscription structure, based on the World Bank List of Economies, categorising countries into “high income countries” “middle income countries” and the “rest of the world” was used in 2024. All categories within the “rest of the world” paid a nominal fee of €10.00 per annum. During the year ended 31 December 2024 the Society published Journals and continued development of its own administration team. The SSIEM held a symposium in Porto, Portugal in 2024 which was attended by 2461 delegates. The Society supported 32 travel scholarships to attend the symposium, which covered the registration fees, accommodation and travel expenses of the awardees. The SSIEM Journal of Inherited Metabolic Disease (JIMD) continued to be run by the JIMD Editorial Office in Heidelberg. The SSIEM Education and Training Advisory Committee (ETAC) exercised its responsibilities for the training syllabi and the recognition of training centres for paediatric metabolic medicine. ETAC also organised the annual SSIEM Academy course which for 2024 was held in Amsterdam, The Netherlands. The SSIEM organised two Dietitian’s meetings. The SSIEM offered modest financial support for non-profit organisations such as parent support groups or societies. In 2024, sixteen applications were received for the first award call and nineteen for the second. These applications were independently judged by a panel from the SSIEM Advisory Council. A total of eight awards were made. Four Travel & Training Bursaries were awarded to healthcare professionals for educational activities, either to gain experience in centres of excellence or to attend conferences or meetings. The SSIEM continued to help fifteen individuals in the Ukraine within the IEM community with supported membership, along with six others from different countries. There were no awards for the SSIEM support for guideline development and their publication in the JIMD for 2024. A total of €78,585 was given in awards, grants and bursaries including symposium scholarships for 2024. ## **FINANCIAL REVIEW** ## **Principal funding** The overall income excluding any surplus from the symposium is used to pay the administrative and running costs of the Society including ETAC and to allow for publication of educational journals devoted to the study of the inborn 4 **The Society for the Study of Inborn Errors of Metabolism** ## **Trustees’ report (continued)** For the year ended 31 December 2024 errors of metabolism and organise training and educational events. Surplus funds are invested. Interest from investments is used in pursuance of the educational objectives of the Society. The Council is cognisant of the current global financial crisis and has taken steps to protect investment and secure the financial position of the Society so that it can continue to meet its objectives. The Honorary Officers and Council have also reviewed the current position with regard to political unrest and ongoing conflicts. The Society is truly international with membership drawn from more than 80 countries. The Society exists to promote the exchange of ideas between all who are professionally interested in Inherited Metabolic Disease. It is the wish of the Council that this exchange should occur between members in as many countries as possible. The Council has agreed to set aside an amount of money from any surplus generated from normal activities to make membership more widely available to those who would otherwise be unable to participate without support from the Society. ## **Results for the year** Overall, the financial result for the year was a net increase in the reserves of €575,445 to a year-end figure of €3,602,320. ## **Reserves policy** It is the policy of the Society to maintain unrestricted funds, which are the free reserves, at a level that is sufficient to cover management and administration, and support costs and allows the Society to be managed efficiently. This reserve is set at €1,000,000 (2023: €1,000,000). The Council proposes that a proportion of the surplus funds are invested, currently €1,027,000 (2023: €1,027,000); the purpose of the investment is to provide the SSIEM with a modest income from its surplus. The remaining surplus is used in pursuance of the educational and charitable objectives of the Society. These include Adult & Dietitian meetings, ETAC Academy and the annual symposium, plus a limited number of awards, grants and bursaries. The latter includes: the Travel & Training Bursaries - to finance individual members to visit, or work for short periods of time in, other centres of expertise; support of non-profit organisations, such as parent support groups holding events or parent/carer projects; Symposium scholarships for travel, accommodation and registration at the SSIEM Symposium and development of Guidelines. As at 31 December 2024 an unrestricted fund balance of €3,602,320 (2023: €3,026,875) was held. The Council regularly reviews the balance and is constantly looking into charitable ways to use the funds. ## **Investment policy and performance** All investments have been acquired in accordance with powers available to the Council. The assets are sufficient to guarantee normal running of the Society for a period of not less than one year and to support the SSIEM Symposium if there were financial difficulties. The Council considers that this is the best way of ensuring the independence of the Society and that its educational objectives can be fulfilled. Since the majority of assets are financial investments there is unlikely to be any delay or shortfall in realising the assets into cash if this becomes necessary. ## **Risk management** The trustees have assessed the major risks to which the Society is exposed, in particular those related to the operations and finances of the Society and are satisfied that systems and procedures are in place to mitigate our exposure to the major risks. 5 **The Society for the Study of Inborn Errors of Metabolism** ## **Trustees’ report (continued)** For the year ended 31 December 2024 The main risks and the methods by which the risks are mitigated are: ## Symposia risk - Insurance against bodily or material harm including third parties. - Insurance against cancellation was considered unacceptably expensive and therefore inappropriate use of funds. However, this can be reviewed with each symposium. - Agreement re a force majeure event. - Making the Symposia a hybrid or virtual meeting if required. It is expected that the above insurance policies and agreements are included in any contract with any Professional Conference Organiser (PCO) providing services for the annual Symposium. ## Data risk - The IT and data facilities are virtual and backed-up routinely. - Compliance with GDPR regulations. Specialist advice has been sought to ensure compliance with GDPR in our contracts with third parties. ## Financial risk - The major risk to the SSIEM is the potential lack of success of the annual symposium which is covered above. - The financial surplus of the Society is conservatively managed and is considered to be low risk as funds are held in Sterling and Euro. ## Political unrest and ongoing conflicts - The Society continues to follow reputable media sources in order to better identify these risks and plan for them. ## **PLANS FOR FUTURE PERIODS** ## **Future developments** ## The Council will continue to: - Develop our administration team. - Review and develop corporate governance. - Review and enhance structures of committees, succession planning and terms of reference. - - Continually assess and manage risks. - - Develop communication links with the members. - Develop/update our Symposium and meetings, including reducing member registration fees. - Support parent support groups or societies through the funding award scheme. - Support healthcare professionals seeking experience at centres of excellence. - Provide support for Guideline Development. - Develop an award for supporting non-SSIEM meetings - Encourage ERNDIM-SSIEM collaboration. - - Encourage joint training initiatives between MetabERN and SSIEM. - Explore new initiatives to support the Society’s aims. ## ETAC will continue to: - Canvas the views of SSIEM members on training issues. - Undertake accreditation visits when requested. - Update the training syllabus on a regular basis. - Consider whether courses in inborn errors of metabolism are suitable for training needs. - Organise further specific training programmes as part of the SSIEM academy. - Encourage ETAC-NAMA Collaboration. 6 tinue and ￿11 furtkn (kve￿ the JIMO. inwtfattor (In frKthe JND repwts &) far as thatTnbStee Is there Is no reknnt a￿tst ofwhith the s(￿.5 auditor The Tntstee hastsken aR the steps that to have t*eft takn as a trustee in ortsto be aware d any reknnt audit lnfrffn￿tIr￿ and to estabfsh that the SrxW's auditrN is awa￿ d that inf(xmation. This rwt was appr￿￿ tythe Tntstees and syd on I￿1r behalf tpr. Prnf P B Trustee Dat&" 41712025 ## **Independent auditor’s report to the Members of The Society for the Study of Inborn Errors of Metabolism** For the year ended 31 December 2024 ## **Opinion** We have audited the financial statements of The Society for the Study of Inborn Errors of the Metabolism (‘the charitable company’) for the year ended 31 December 2024, which comprise the Statement of financial activities, the Statement of financial position, the Statement of cash flows and the related notes, including a summary of the principal accounting policies and the notes to the financial statements. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards, including Financial Reporting Standard 102 ‘The Financial Reporting Standard applicable in the UK and Republic of Ireland' (United Kingdom Generally Accepted Accounting Practice). In our opinion the financial statements: - give a true and fair view of the state of the charitable company’s affairs as at 31 December 2024 and of its income and expenditure for the year then ended; - have been properly prepared in accordance with United Kingdom Generally Accepted Accounting Practice; and - have been prepared in accordance with the requirements of the Companies Act 2006. ## **Basis for opinion** We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the auditor's responsibilities for the audit of the financial statements section of our report. We are independent of the charitable company in accordance with the ethical requirements that are relevant to our audit of the financial statements in the United Kingdom, including the FRC's Ethical Standard, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion. ## **Conclusions relating to going concern** In auditing the financial statements, we have concluded that the Trustees' use of the going concern basis of accounting in the preparation of the financial statements is appropriate. Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the charitable company’s ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue. Our responsibilities and the responsibilities of the Trustees with respect to going concern are described in the relevant sections of the report. 8 ## **Independent auditor’s report to the Trustees of The Society for the Study of Inborn Errors of Metabolism (continued)** For the year ended 31 December 2024 ## **Other information** The Trustees are responsible for the other information contained within the annual report and financial statements. The other information comprises the information included in the annual report, other than the financial statements and our auditor's report thereon. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon. Our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in the audit or otherwise appears to be materially misstated. If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether this gives rise to a material misstatement in the financial statements or a material misstatement of the other information. If, based on the work we have performed, we conclude themselves that there is a material misstatement of this other information, we are required to report that fact. We have nothing to report in this regard. ## **Opinion on other matters prescribed by the Companies Act 2006** In our opinion, based on the work undertaken in the course of the audit: - the information given in the Trustees' report, which is also the directors’ report for the purposes of company law, for the financial year for which the financial statements are prepared is consistent with the financial statements; and - the Trustees' report, which is also the directors’ report for the purposes of company law, has been prepared in accordance with applicable legal requirements. ## **Matters on which we are required to report by exception** In the light of the knowledge and understanding of the charitable company and its environment obtained in the course of the audit, we have not identified material misstatements in the Trustees' report. We have nothing to report in respect of the following matters in relation to which the Companies Act 2006 requires us to report to you if, in our opinion: - adequate accounting records have not been kept, or returns adequate for our audit have not been received from branches not visited by us; or - the financial statements are not in agreement with the accounting records and returns; or - certain disclosures of Trustees' remuneration specified by law are not made; or - we have not received all the information and explanations we require for our audit; or - the Trustees were not entitled to prepare the financial statements in accordance with the small companies regime and take advantage of the small companies exemptions in preparing the Trustees’ report and from the requirement to prepare a Strategic report. ## **Responsibilities of Trustees** As explained more fully in the Trustees' responsibilities statement on page 3-4, the Trustees (who are also the directors of the charitable company for the purposes of company law) are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as the Trustees determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error. 9 ## **Independent auditor’s report to the Trustees of The Society for the Study of Inborn Errors of Metabolism (continued)** For the year ended 31 December 2024 In preparing the financial statements, the Trustees are responsible for assessing the charitable company's ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless the Trustees either intend to liquidate the Society or to cease operations, or have no realistic alternative but to do so. ## **Auditor's responsibilities for the audit of the financial statements** Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an Auditor's report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements. Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, including fraud is detailed below. Our approach to identifying and assessing the risks of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, was as follows: - the engagement partner ensured that the engagement team collectively had the appropriate competence, capabilities and skills to identify or recognise non-compliance with applicable laws and regulations; and - the audit team held a discussion to identify any particular areas that were considered to be susceptible to misstatement, including with respect to fraud and non-compliance with laws and regulations; and - we obtained an understanding of the legal and regulatory frameworks that are applicable to the Society and determined that the most significant frameworks which are directly relevant to specific assertions in the financial statements are those that relate to the reporting framework (Statement of Recommended Practice: Accounting and Reporting by Charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the United Kingdom and Republic of Ireland (FRS 102) and the Charities Act 2011), the Companies Act 2006 and those that relate to data protection (General Data Protection Regulation). We assessed the susceptibility of the charitable company's financial statements to material misstatement, including obtaining an understanding of how fraud might occur, by: - making enquiries of management as to where they considered there was susceptibility to fraud and their knowledge of actual, suspected and alleged fraud; and - considering the internal controls in place to mitigate risks of fraud and non-compliance with laws and regulations. To address the risk of fraud through management bias and override of controls, we: - performed analytical procedures to identify any unusual or unexpected relationships; - assessed whether judgements and assumptions made in determining the accounting estimates set out in the accounting policies were indicative of potential bias; and - tested journal entries to identify unusual transactions. 10 ## **Independent auditor’s report to the Trustees of The Society for the Study of Inborn Errors of Metabolism (continued)** For the year ended 31 December 2024 In response to the risk of irregularities and non-compliance with laws and regulations, we designed procedures which included, but were not limited to: - agreeing financial statement disclosures to underlying supporting documentation; - reading the minutes of meetings of those charged with governance; and - enquiring of management as to actual and potential litigation and claims. There are inherent limitations in our audit procedures described above. The more removed that laws and regulations are from financial transactions, the less likely it is that we would become aware of non-compliance. Auditing standards also limit the audit procedures required to identify non-compliance with laws and regulations to enquiry of the Trustees and other management and the inspection of regulatory and legal correspondence, if any. Material misstatements that arise due to fraud can be harder to detect than those that arise from error as they may involve deliberate concealment or collusion. A further description of our responsibilities for the audit of the financial statements is located on the Financial Reporting Council's website at: www.frc.org.uk/auditorsresponsibilities. This description forms part of our Auditor's report. ## **Use of our report** This report is made solely to the charitable company’s members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the charitable company’s members those matters we are required to state to them in an Auditor's report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the charitable company and the charitable company’s members, as a body, for our audit work, for this report, or for the opinions we have formed. Alison Pyle (Senior statutory auditor) for and on behalf of **Buzzacott Audit LLP** Statutory Auditor 130 Wood Street London EC2V 6DL Date: 9 July 2025 11 **The Society for the Study of Inborn Errors of Metabolism** ## **Statement of financial activities (incorporating an income and expenditure account)** For the year ended 31 December 2024 |**Income and expenditure**
**Note**
**Income from:**
Charitable activities – symposium and memberships
3
Charitable activities – journal royalties and courses
4
Investments
5
**Total income**
**Expenditure on:**
Charitable activities
6
**Total expenditure**
**Net income before investment**
**gains and losses**
Unrealised (loss)/gain on revaluation of fixed asset
investments
10
Net realised loss on investments
10
Gain on retranslation of fixed asset investments
10
**Net movement in funds**
**Reconciliation of funds:**
Total funds at the beginning of the year
**Total funds at the end of the year**
14|**Unrestricted**
**funds**
**2024**
**€**
**2,505,204**
**383,291**
**28,469**
**2,916,964**
**2,363,786**
**2,363,786**
**553,178**
**(13,486)**
**(17,461)**
**53,214**
**575,445**
**3,026,875**
**3,602,320**|Unrestricted
funds
2023
€
240,951
403,377
27,481| |---|---|---| |||671,809| |||609,247| |||609,247| |||62,562
44,133
(5,676)
21,649| |||122,668
2,904,207
3,026,875| The Statement of financial activities includes all gains and losses recognised in the year. All of the Society’s activities derived from continuing operations during the above two financial years. The notes on pages 15 to 22 form part of these financial statements. 12 As at 31 DeCern￿ 2024 L147267 Debtor& ofter than or* par 35L9Ta Cash at bank and kn hand I.T27.IJM 2J178977 175U I￿9369> 1.879.fA 3,026￿75 14 3.026.875 3.026.875 The finandal ststemerrts apwoved bytheTru5tees ￿ +/ ¥/2SaThJ on their behaifby. ￿￿￿p B MIIS 13 **The Society for the Study of Inborn Errors of Metabolism** ## **Statement of cash flows** For the year ended 31 December 2024 |**2024**
**€**
**Cash flow from operating activities:**
Net cash generated from operating activities
**A**
**499,630**
**Cash flow from investing activities**
Purchase of investments
**(192,864)**
Disposal of investments
**197,859**
Investment income
**28,469**
**Net cash generated from investing activities**
**33,464**
**Change in cash and cash equivalents in the year**
**533,094**
**Cash and cash equivalents at beginning of year**
**1,727,004**
**Cash and cash equivalents at end of year**
**B**
**2,260,098**
**A Reconciliation of net income to net cash flow from operating activities**
**2024**
**€**
**Net income for the year (as per the Statement of financial activities)**
**575,445**
**Adjustments for:**
Loss/(gain) on revaluation of investments
**13,486**
Loss on disposal of investments
**17,461**
Gain on retranslation of fixed asset investments
**(53,214)**
Investment income
**(28,469)**
(Increase)/decrease in debtors
**(138,982)**
Increase /(decrease) in creditors
**113,903**
**Net cash generated from operating activities**
**499,630**
**B Analysis of cash and cash equivalents**
**2024**
**€**
Cash at bank and in hand
**2,196,737**
Cash held by investment managers
**63,361**
**Total cash and cash equivalents**
**2,260,098**|2023
€
98,367| |---|---| ||(227,367)
182,358
27,481| ||(17,528)
80,839| ||1,646,165
1,727,004
2023
€
122,668
(44,133)
5,676
(21,649)
(27,481)
277,501
(214,215)
98,367
2023
€
1,690,288
36,716
1,727,004| 14 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **1. General information** The Society for the Study of Inborn Errors of Metabolism (‘the Society’) is a company limited by guarantee. The members of the Society are the Trustees named on page 1. In the event of the Society being wound up, the liability in respect of the guarantee is limited to £1 per member of the Society. The Society is incorporated in England and Wales. Its registered office is C/O Stone King LLP, Boundary House, 91-93 Charterhouse Street, London, EC1M 6HR and principal place of business is PO Box 3375, South Croydon, CR2 1PN. The company registration number is 02567711 and the charity registration number is 1010639. ## **2. Accounting policies** ## **2.1 Basis of preparation of financial statements** The financial statements have been prepared under the historical cost convention, with the exception of investments, which are included on a market value basis. The financial statements have been prepared in accordance with the Statement of Recommended Practice: Accounting and Reporting by Charities applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (Charities SORP FRS 102), Section 1A of Financial Reporting Standard 102, ‘The Financial Reporting Standard applicable in the UK and Republic of Ireland’ (‘FRS 102’), the Charities Act 2011 and the Companies Act 2006. The Society constitutes a public benefit entity as defined by FRS 102. The financial statements are presented in Euro (€) and rounded to the nearest Euro (€). This is the functional currency of the charity. The principal accounting policies adopted, judgements and key sources of estimation uncertainty in the preparation of the financial statements are as follows: ## **2.2 Going concern** After making appropriate enquiries, the Trustees have a reasonable expectation that the Society has adequate resources to continue in operational existence for the foreseeable future and have identified no material uncertainties in this regard. For this reason, the Society will continue to adopt the going concern basis in preparing the financial statements. ## **2.3 Fund accounting** The general fund is an unrestricted fund which is available for use at the discretion of the Trustees in furtherance of the general objectives of the Society and which has not been designated for other purposes. ## **2.4 Income** All income is recognised in the Statement of financial activities when the Society has entitlement to the income, it is probable that the income will be received and the amount of income receivable can be measured reliably. ## _Annual symposium_ Symposium income is the gross or the net proceeds from revenue generated by the symposium organiser on behalf of SSIEM depending on whether the symposium organiser is acting as the agent or the principal. This revenue includes the registration fees and sponsorship fees at the event. 15 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **2. Accounting policies (continued)** ## _Subscriptions income_ Income from subscriptions are recognised in the period the membership relates to. ## _Journal royalties_ Journal royalties are recognised on an accruals basis. ## _Investment income_ This comprises interest on bank deposits and National Savings Bank income bonds and dividend income. Interest on funds held on deposit is included when receivable and the amount can be measured reliably by the Society. This is normally upon notification of the interest paid or payable by the bank. Dividends are recognised once the dividend has been declared, and notification has been received of the dividend due. ## **2.5 Expenditure** Liabilities are recognised as expenditure as soon as there is a legal or constructive obligation committing the Society to make a payment to a third party or it is probable that a transfer of economic benefits will be required in settlement and the amount of the obligation can be measured reliably. All expenditure is stated inclusive of irrecoverable VAT. All expenditure is accounted for on an accruals basis. Expenditure comprises direct costs and support costs. All expenses, including support costs, relate to the charitable activities of the Society. Expenditure on charitable activities includes all costs associated with furthering the charitable purposes of the Society through the provision of its charitable activities. Such costs have been apportioned as follows: - Direct costs – These are the costs associated directly to meeting the charitable objects of the Society and include annual symposium expenditure, grants payable and costs incurred in respect of producing journals. - Support costs – These are the costs incurred directly in support of expenditure on the objects of the Society and include project management carried out at Headquarters. - Governance costs – These are the costs directly attributable to the meetings and audit process such as staff costs, printing, meetings and travel costs. ## _Annual symposium_ Symposium expenditure is the gross expenses incurred, when the symposium organiser is acting as agent for the Society. ## _Grants payable_ Grants payable are charged in the year when the offer is made except in those cases where the offer is conditional, with such grants being recognised as expenditure when the conditions attached are completed by the Society. Grants offered subject to conditions which have not been met at the year-end are noted as a commitment but not accrued as expenditure. ## **2.6 Fixed asset investments** Investments are stated at market value at the reporting date. The Statement of financial activities includes the net gains and losses arising on revaluations and disposals throughout the year. ## **2.7 Debtors** Trade and other debtors are recognised at the settlement amount after any trade discount offered and net of any provision. Prepayments are valued at the net amount prepaid. 16 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **2. Accounting policies (continued)** ## **2.8 Cash at bank and in hand** Cash at bank and in hand includes cash and short term highly liquid investments with a short maturity of three months or less from the date of acquisition or opening of the deposit or similar account. ## **2.9 Liabilities and provisions** Liabilities are recognised when there is an obligation at the reporting date as a result of a past event, it is probable that a transfer of economic benefit will be required in settlement, and the amount of the settlement can be estimated reliably. Liabilities are recognised at the amount that the Society anticipates it will pay to settle the debt or the amount it has received as advanced payments for the goods or services it must provide. ## **2.10 Financial instruments** The Society has only financial assets and financial liabilities of a kind that qualify as basic financial instruments. Basic financial instruments are initially recognised at transaction value and subsequently measured at their settlement value. ## **2.11 Foreign currencies** Monetary assets and liabilities denominated in foreign currencies are translated into Euros at rates of exchange ruling at the balance sheet date. Transactions in foreign currencies are translated into Euros at the rate ruling on the date of the transaction. Exchange gains and losses are recognised in the Statement of financial activities incorporating income and expenditure account. ## **3. Income from charitable activities – symposium and memberships** |Annual symposium
Subscriptions
Academy income|**Total**
**funds**
**2024**
**€**
**2,375,574**
**129,630**
**-**
**2,505,204**|Total
funds
2023
€
105,009
127,852
8,090
240,951| |---|---|---| ## **4. Income from charitable activities – journal royalties and courses** |Journal royalties
Courses
Academy income|**Total**
**funds**
**2024**
**€**
**374,653**
**1,170**
**7,468**
**383,291**|Total
funds
2023
€
398,587
4,790
-
403,377| |---|---|---| 17 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **5. Income from investments** |Interest income
Dividend income
**6.**
**Analysis of charitable activities**
**Direct costs**
Council symposium expenses
Publication of the JIMD
JIMD Honorarium
JIMD Illustrations
Academy expenses
Symposium expenses
Courses
Awards/bursaries and grants
**Total direct costs**
**Support costs**
Salaries and wages (note 9)
Council travel and subsistence
Printing, postage, stationery and carriage
Gain on exchange rate variance
Website costs
Other administration expenses
Secretarial expenses
Telephone and fax
IT supplies
Irrecoverable VAT
**Total support costs**
**Governance costs**
Audit & accountancy fees
Professional charges
**Total governance costs**
**Total expenditure on charitable activities**|**Total**
**funds**
**2024**
**€**
**15,998**
**12,471**
**28,469**
**Total**
**funds**
**2024**
**€**
**12,123**
**130,244**
**21,000**
**1,222**
**68,888**
**1,645,257**
**9,970**
**78,585**
**1,967,289**
**123,702**
**6,318**
**1,076**
**58**
**6,773**
**22,122**
**198**
**1,134**
**8,178**
**195,560**
**365,119**
**30,395**
**983**
**31,378**
**2,363,786**|Total
funds
2023
€
13,442
14,039
27,481
Total
funds
2023
€
20,776
154,514
21,000
300
47,122
48,741
39,864
56,517| |---|---|---| |||388,834
115,300
11,698
1,184
(8,108)
9,320
26,456
375
1,010
9,628
19,353| |||186,216
30,259
3,938| |||34,197
609,247| 38 individuals were supported with financial grants of €32,785 (2023: €31,528 (36 individuals)) during the year. 18 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **7. Trustees’ remuneration** No Trustees received any remuneration or benefits in kind in respect of their services during the year (2023: €Nil). During the year, 13 Trustees received reimbursement of expenses of €15,660 (2023: €11,654, 14 Trustees). ## **8. Auditor’s remuneration** Auditor's remuneration amounts to a current year audit fee of €21,809 (2023: €20,923) and fees charged for other non-audit services amounts to €8,586 (2023: €6,801). ## **9. Staff costs** |Wages and salaries
Social security costs
Pension costs|**2024**
**€**
**99,599**
**10,784**
**13,319**
**123,702**|2023
€
96,394
11,832
7,074
115,300| |---|---|---| The average monthly number of employees during the year was 2 (2023: 2). The number of higher paid employees was: |€60,001 – €70,000
€70,001 – €80,000|**2024**
**€**
**1**
**-**
**1**|2023
€
**-**
1
1| |---|---|---| Within Symposium costs are amounts totalling €16,376 (2023: €Nil) payable to two employees. The Society considers the Board of Trustees, the administrator and executive administrator as their key management personnel. The total employment benefits (including employer’s national insurance contributions and employer’s pension contributions) of key management personnel was €123,702 (2023: €115,300). 19 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **10. Fixed asset investments** |**Analysis of investments**
Investments at market value comprise of the following:
Fixed income
Equities
Alternatives
At 1 January 2024
Additions at cost
Disposals at book value (proceeds: €197,859 loss: €17,461)
Unrealised (loss)/gain on revaluation of fixed asset
Investments
Gain on retranslation of fixed asset investments
At 31 December 2024
Historic cost at 31 December 2024||**2024**
**€**
**556,584**
**567,879**
**40,076**
**1,164,539**
**2024**
**€**
**1,147,267**
**192,864**
**(215,320)**
**(13,486)**
**53,214**
**1,164,539**
**1,139,684**|2023
€
1,042,152
227,367
(188,034)
44,133
21,649| |---|---|---|---| ||||1,147,267| ||||2023
€
483,639
613,005
50,623
1,147,267
963,104| Investments are held to provide an investment return. All fixed asset investments are held in the UK. ## **11. Debtors: amounts falling due after more than one year** |Deposits|**2024**
**€**
**11,537**
**11,537**|2023
€
-
-| |---|---|---| 20 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **12. Debtors: amounts falling due within one year** |Trade debtors
Symposium related debtors
Deposits
Other debtors
Prepayments and accrued income|**2024**
**€**
**390**
**-**
**34,610**
**78,846**
**365,572**
**479,418**|2023
€
849
104,904
30,005
-
216,215
351,973| |---|---|---| ## **13. Creditors: amounts falling due within one year** |Trade creditors
Other creditors
Other taxation
Accruals and deferred income
Deferred income at beginning of year
Resources deferred during the year
Amounts released from previous years
Deferred income at end of year||**2024**
**€**
**126,454**
**2,100**
**74,394**
**110,324**
**313,272**
**2024**
**€**
**32,433**
**32,371**
**(32,433)**
**32,371**|2023
€
51,002
1,122
3,720
143,525
199,369
2023
€
36,306
32,433
(36,306)
32,433| |---|---|---|---| Deferred income relates to the deferral of subscription income over the period to which it relates. 21 **The Society for the Study of Inborn Errors of Metabolism** ## **Notes to the financial statements** For the year ended 31 December 2024 ## **14. Unrestricted funds** |General fund
General fund|**Balance at**
**1 January**
**2024**
€
**3,026,875**
**3,026,875**
Balance at
1 January
2023
€
2,904,207
2,904,207|Income
€|Expenditure
€
(2,363,786)
(2,363,786)

Expenditure
(restated)
€
(609,247)
(609,247)|Gains from
investments
€|Transfers
between
funds
€|**Balance at 31**
**December**
**2024**
**€**| |---|---|---|---|---|---|---| |||2,916,964||22,267|-|**3,602,320**| |||2,916,964||22,267|-|**3,602,320**| |||Income
(restated)
€||Gains from
investments
€|Transfers
between
funds
€|Balance at 31
December
2023
€| |||671,809
671,809||60,106
60,106|-
-|3,026,875
3,026,875| The general fund represents the ‘free reserves’. ## **15. Related party transactions** There are no other related party transactions during the year (2023: None). 22