for the YeAr Ended 31-Iletr24 Hnmatt Contents Report of the Trustees Page5 1 to 3 R¢¢¢ipts and Payments A¢¢ount HumaD O Preservation Research Trnst rt of the Truslee for the Year Ended 31 December 2024 nd Aellvltl Objectives: l) Principally to ￿ndUct promote develop and co￿lnate for the benefii of the public research with a view to en8blin8 the preservation of hum8m organs after death for transplant Purposes. 2) Secondly, to wnduct promote develop and ctrordinate for the b¢n¢fJt of the public research into the a8ein8 pnKes$. Aetlvftles: Human Organ Preservation Research Trust acts as an inform￿10n rc50urce for potential cryonics patients and their familTes, other cryonics groups. medica] service providers, regulatory bodies, the media and the general public. We carry out research and development in respect of emergency protocols techniques and equipmenL We also reseaKh the legal and logistical considerations affecting cryonics. The fruits of our research and development are made wailabl¢ in the forni of operational documentation, prnctical training. tsChnI￿ reports and thum¢nt t¢mplat¢s. We also provide ￿Oni¢S emergency assistance to members of the public. ClasslfleAtIon: What- The advancement of education. the •dvwK¢m¢nt of h¢41th or saving of liv* th¢ advancement of ￿lenCe Who- The general public I mankind How- Sp)nsory undertakes or provides educ￿]0￿ r¢search and the relief of human sufferin8 hlevem The following activities were carried out to further ourobjectives:_ TralnlDg and D¢vdopment: January - Air transportable response kit &8sembled for in*TnatI￿j deployments that canl be reached by road in time or at all. J8nu8ry - Hosted public training day in London w *a¢h and prxtice sthbilisa¢lo￿ perfvsion and transportation protocols for cryonics, with the ¢mph•sis on miThimisin8 c¢llular deleriorntion, particularty to retain brnin inte8rity and inforni•tion retention. April - Hosted public training day in Sh¢ffi¢ld ¢0 teach and prnctice stabilisation. perfusion and trAnsportatjon proiocols for cryonics, with the emphasis on miThimisinB c¢llular deteriorntson. particulvty to retsin brnin integrity and inforniation retention. June - Hosted public training day in l￿ndOn lo teach and prnctice sthbilisation, perfusion and transportation protocols for ryonics, with the cmplwis on minimisin8 ¢¢llular deterioralioffj particularly to relain brain inl¢grity and inforniation retention. August- International COwordin2tion meeting in London with Alcor Life Ethnsioft Foundation CEO James Arrowood and a representative from Alwes DART emergency team. This w&s followed by a public knieet Alcofs CEO, discussion and dinner. September- Hosted public training day in Bristol to teach and prnctiee stabilisation. perfusion and transportation protocols for ryonics. with the emphasis on minimisin8 ¢¢llular del¢riorallo￿ particularly to relain brain integrity and infonnation relention. Publle Awareness: 77 email enquiries fr￿n members of the publi 42 email enquiries from the mdi Jonuary.March- Interviews with Metro. July.September- Intervi¢ws for pOd¢￿t produced by Dut¢h na¢ionaJ newspapu. NRC. October- Danish N￿lon81 Film School documenthry released via The New YoTk¢r. December- Interview with Jemima Lewis for her upwming iwk. rvation R rt of the Trustee for the Year En 31 Deeember 2024- eontinued Researeh: Febnwy-march - Two eryonics cases were handled Simultaneously by Cryonics UK. the patients having died one day apart. Both cases were in London and involved a last minute sign-up with US cryonics storage provider. Cryonics Institute. Both patients were transferred to the US on the same fli8hL demonstrating that the 200kg dry ice limit was applied per wntainer rather than per aircraft by th¢ airline. - Case I: This w&s a cancer patient who benefitted from a full standby* Stabilisation and CryOPTOtective perfusion. The Cryonies UK emergency team deployed with a paramedic to assist with stabilisation and perfusion procedures. This was the first use of the revised VMI perfusion protowl utilising an initial perfusate concentration of 5%. This was the first cryonics ease in the UK to be subject to the jurisdiction of the newly c￿ted role of the Medical Examiner. The ME is responsible for double checking the medical history and ¢ause of death issued by the attending doctor. The ME also has the power to refer the matter to the coroner. - Case 2: This patient had suffered an unexpected death and cryopreseryation arngements were made post n￿rtern. Consequently. the patient was subject to a'straight freeze, as stsbilisation and perfusion ￿t ¢)nly ￿rrIed out if the patient can be reached relatively quickly. August- Cryonics Me in Newark involving a last minute sign-up with Cryonics Institute. This cancer patient passed away before the emergency team reached them, however, due to the relatively short delay, they W¢Te 5tTII able to benefit from stabilisation and Cryoprotective perfusion. The Cryonics UK emergency team deployed with a paramedic and a nurse to provide verification of expected death and to assist with stabilisation and perfi￿lon procedure& Publie Bene The trustees have had regard to the guidance issued by the Charity Commission on public benefit and confirn] they have eomplied with their duties under section 4 of the 2006 Charities A¢t. Mana ernent The charity is an unincorporated trust which is governed by a trust deed adopted on 7 December 1990 and amended on I January 2021. It was registered as a charity by the Charity Commission for England and Wal¢s on 31 January 1991. The charity acts by way of its con)orate trLTStee. HOPRT Trust¢¢ Ltd with wmpany number 11926484. HOPRT Trustee Ltd is managed by a board of directors in collaboration with an advisory committee. The apwinknent of trustees is mede by those existing as Tntstees. We meet regularly to review the business of the Charity. Fin The attached financial stal¢ments show the current state of the finances which the board wnsider to be sound. To accumulate reserves in order to fund I￿ge equipment purchases and research projects. Aims for the Futu Increase involvement of volunteer& espe¢ia]ly younger people, particularly in training. Improve efficiency of sign-up proRdure. particularly under emergency circumstances. Improve HOPRT'S banking arrangements. Continue with updates of operational documentation. Continue to explore avenues for raisin8 public awareness of ¢ryopreservation research and techniques. Research new avenues for improved equipment and cryopreservation techniques. Raise further funds to be able to afford larger scaIe research projects. Increase international co-operntion between cryonics groups. improve international emergency readiness and host periodic trnining events around the UK. Human nPre erv ort of the Tru ee f r the Year Ended 31 December 2024- continued Ref¢renee and Admkntstrnt5ve Infonnatlon Admlnlstr4tlon: Human Organ Preservation Research Tw$t known as Cryonics UK Corresponden¢e Addres$: 57 Highfields Road Dronfield S18 IUW IDdepend¢nt Examlner: Mark Spittlehousc A&MPG Limited 6 Meadowhe8d Sheifield S8 7UD Banklng Addresj: Natwest l The Mall, Ealin& London, W5 2PL CAF Bank 25 Kings Hill Avenue, Kings Hlll, West Mallin8. Kent, MEI 9 4JQ Reglsttred Charlty Number: 1001750 AS a charity, Hum8n Or88n Preservation Research Trust has a wryorate trustee that oversees the running of the organisation. Truste4: HOPRT TNstee Ltd (from 1st January 2021) OperAtlng Name Cryoni¢s UK Deelaratlon I declare that I have approved the Trustee's Report above and l am authorised to sign it on behalf of the TNstee, Full Name: Tim Gibson Position: Trustee Board Member Signature: rim Gibson Date: 16th October 2025 rt to the Trustees Hujnan O Preservation R rchT I report to the TrUst￿S on my examination ofthe accounts ofHuman 0[￿ PreSeN￿lon Researth TnW for the year ended 31 December 2024. Respn5ibilitits baals of r¢port As the ¢harity trustees ofthe Trust you are respojtsible forthe preparation of the accounts in aC￿rdon¢¢ with the ￿ulTeMents of the Charities Ad 2011 ('the Act,). I report in respect of my examinalion orth¢ Tn￿¢.$ a¢counts curies out under Seclion 145 of the 2011 Aci and in carrying out my examinalion I hfft follow￿ all 4)p11￿]e DIrea1￿ 8iven by the Charity Commission undttsethion 145(5)(b) of the ACL Indtp¢lldent Ex*mlDer'$ Stslem¢nt I bave complded my examination. I confimi that no ntster1￿ matters have com¢ to my attention in with the examinalion whith gives Jne ￿ to bdieve that IQ any matetiai T•.. l Acwuniing records were noi kept in rwe¢t ofthe Tnw a5 T¢qUir￿1 by Section 130 of th¢ Ad. or 2 the accounts did accord with the ￿COun11n8 recor¢ts' or 3 the aCC4)u￿ did not comply with lh¢ applicabl¢ requirements concerning the forni and content of accounts set Oui in the Charities (Accounts and Repots) Re8ulations 2008 other than any requirement that the accounts give a'lrue and fair. view which is not h matter ¢onsidered as part of an independent examin￿On. I bav¢ DO wn¢¢rns ond hav¢ across no other motters in ¢4)m￿￿10n with the examination to which auention should be drawn in this Teport in ord¢r to eDable a proper widerstandin8 or the accounts to be reached. Zf/,,/ Mr M Spittlehouse MAAT A&MPG Limited 6 Meadowhead Sheffield S8 7UD god P8 R¥trIrt￿ Uart¥trlctlve fuods Totsl Bala[￿& br•u8bt forwArd 6J47 164 18J84 54.197 19 18.584 54.197 19 5,924 CAFGold&p)sil PayPal accoym 164 17J03 24.nj 56P34 5.924 56.034 69.765 17J03 79.r27 79.727 Rece5pts IDvesiment iTKome ItrAth interex) 1.143 eACtiViiies". 9lJ97 24204 15J92 13JJ9 115.ODI 15.892 13JTr) 17JO3 Subserioioj Sdeofequiwnent 13.6r2 I3￿72 37 37 91J97 54.749 146.146 I7￿3 34ffi15 f charitsble aaivii. (744 S&831 &744 $1831 253 19J70 19J70 Ambul￿￿¢ nmTrlnBc￿ts motor& ￿¥¢1 costs Tr)inibwJ& publr¢ M￿1￿¢0￿5 377 377 IJ￿3 142 755 24$ 4.755 lJ82 755 245 142 4.755 1057 1.447 lJ28 remal & refills 475 139 lJ89 Bank char8es 66 557 557 103 35 19 3$ 19 *540 10.911 19.762 7.312 27.074 TofAI Styrplu•1(der￿1I 23J47 43131 67.185 (2259) 7.541 Other PAyments: 7J27 75n 123591 89J27 Repreyented br. CAF Ctsh ¢uThenta¢¢w 17206 17J 6.347 164 7.220 56.034 69.765 OJ47 164 24.723 56.034 368 NAtW¥t ¢wr¢ftl8ccount N￿W¢s¢ de￿511 23J47 17y13 18.056 70&46 41.402 149 17J03 17 no 16*bllltiu 8t ber 21124 2024 UDrestrl¢tfve funds Restriettd fun Restrl¢ted Unmlrictive Totsl Totsl Flxed Assets Ambulance- LK09 HDF Equipment 10.723 19.045 29.768 10.723 19.045 29.768 10.723 10,723 22241 22241 Current Assets Stook 10.891 10.891 8.927 8.927 17206 172Q6 6.347 6,34? CAF Gold d¢posi¢ axount Natwest ewrentaeeiwnt 23J47 17.503 40.850 18.056 70,646 106.076 41.402 88,149 146,926 17503 7220 56.034 69,765 24.723 56.034 87268 NatW¢￿ deposit aceourti 17503 Total As*ts 40JS0 146.735 187J85 17J03 IIJO,933 118.436 Re rdented Balance blf 17,503 23,347 IIX),933 118,436 23.347 43.838 1.964 187J85 19,762 (2259) 91,307 111.069 (2359) 9.800 {174) 118A36 Restrictive fithdssurplus I(der￿LI) Unrestricuve thnd su￿lUSI(def￿11) str￿ rev81uation B&iAn¢* elf 43.838 9.800 174 IIJO,933 146,735 17JlJ3 Trust Veor Ended 31 ber 2024 A¢¢othDting Polielts The accounts (financial sts*ments) have been pr¢pared in accordance with A¢You0in￿ #Dd Reportin8 by Clwities: Sts*m¢ni of Recommended Practice applicabl¢ io ¢lwiiie5 prep8rinB th¢ir a¢counts in accordanc¢ with the Finan¢1￿ Reporting Standord applicable in thc UK and Repyblic of Irelqnd (FRS102) issued Isi January 2019, the Fin8nci&I Rcportln8 StandArd opplAcobl¢ in the UK and Rq>ublic of IT¢land IFRS102). and th¢ Charili¢s A￿ 2011. Th¢ (financial stalements) have been prepwed to 8ive a'true and fair. vt¢w have d¢pwtsd frorn the Charilies (Arcoun and Rcportsl R¢8ulailons 2008 0￿Y to th¢ ¢xl¢nt r¢quir¢d lo provtth a'lTue and fair. VKW. This d¢partur¢ kn involved followin8 the A¢¢ouniin8 and Re￿rtIn8 by Charities.. Statement of Re￿nUncnd¢d Practic¢ applicable to ¢lwitigs preparin8 their accounts in accordance with the Financi￿ R¢p)rtin8 Standard Hpplicable in the UK and Ryblic of Ireland (FRS102) Issued 1st Jaftuary 2019 rather than thc Accountill8 and Ryning by Clwities.. Statement of Rec4*￿ Pr8ctic¢ effeaive from l April 2005 whi¢h h% sinc¢ t¢en withdrawn. Income This is •eMunted for on a reL%ivllble b￿lS in the puiod in whicb it is r¢¢eived b) PaJ)n¢nts ThH¢ arc a¢L¥Junt¢d for 4$ pai The chthty m#ts the defitiitsoll of a publi¢ iKneflt enlity und¢r FRSIO2. Th¢ Trusle¢s C4JTh8i&r th¢r¢ ATe no mat¢Tial Un¢lun*tts for $￿pe￿IlOn and equiptheni costs in¢uffed in canying oui the ¢hviry'8 adiviti¢J. There are no othe# rel￿ed party trai)ga¢tlons ￿ not¢. Trustees. Remuntration No remuneratitsn or ¢molum￿¢S w¢r¢ r¢¢¢1¥￿ by th¢ Tn￿1¢¢$ dth¢r in th¢lr ￿p&￿ty 45 or a5 ofthe BoaTd or Trumces and no emolurnents paid in excess of £60,000. T#xAti The chority is r¢8iStered Is a charity and no t￿tIon is p8yabl¢ on th¢ ¢xcess of inc4)me overexpendinwe.