Human Or an Preservation Research Trust ort and Financial Statetnents for the Year Ended 31 December 2022 Charit Number 1001750 Amended Hurnan O an Preservation Re5varch Trust ort of the Trustees for the Year Ended 31 Decernber 2022 Ob'ective5 and Activit1¢5 Objectives: I I Principally to conduct PToniote develop and co-ordinate forthe bertefii of the public research wilh a view io enabling the preservation of human organs after death for transplant purposes. 21 Secondarily io ¢ondu¢t prornot¢ develop and co-ordinate for the benefjt of the public research into the a8ein8 process. Activitie$: HuTnan Organ Preservation Research Trust acis as on infom)ation resouwe for poieniial cryonics patients and their families. other cryonics groups. medical service providers. regulaiory bodies, the media and the general public. We carry out research and development in ￿5p¢(l of emergency protoco15. techniques and equiprn¢nt. We also res¢arch the legal and logistical considerations affecting cryonics. The fruits of our research and dcveloprnent are Tnade available in the form of operational documentation, practical traitjing. technical report5 and docuTnent teTnplat¢s. We also provide cryonics emergency assistance to members of the public. C1#55ific#tiott: Whal- The advancement of education. the advancement of health or saving of lives. the advancement of science Who- The general public I mankind How- Sponsors, undertakes or provides education, research and the relief of human suffering Achievements And Performance The following activities were carried out to further our obje¢tives."- Training and Developrnent: March - Initial contscts made to sour¢e Cryonics siabilisation medications within UK. It was determined that buying through local phartnacies, rather than wholesalers. may prove more successful due to the small and infrequeni quaniities required. March - Host￿ publi¢ trairtiDg day itt Sheffield to teach and practice stabilisation, perfusion and trdnsportation protocols for cryonics, with the ernpha5is on minirnising cellulaT deterioTaiion, partlcularly to retain brain integrity and infomation retention. April- New batch of M22 perfusate and stabilisation medicatiOll5 received from US cryonics provider, Alcor. May - S¢ope of Power of Attorney docurnents expanded to enable incre&sed functionality following live case experience. May - Meeting to brief independeni ambulancelparamedi¢ service provider and discuss potential de21 to provide professional Med￿Cal staff foi cryoni¢s training and liv¢ ¢all-outs. March-july - Cryoni¢s UK manual updaied to caier for evolving stabilisation, perfusion and transportation pn)tocols. July - Hosted public training day Èn Sheffield to teach and pra¢tTrce stabilisation, perfusion and transportation protrtols for ¢ryonics, with the emphasis on minimisin8 cellular deterioration, particularly to retain brain integrity and information re¢¢ntion. August - Meeting with venture ¢apitsl ¢ompany to discuss substantial cryonics developtnent project. Detai15 confidelltial due io ongoing naiure of proposals. September- Hosted public training day in London to teach and pra¢ti¢e stabilisation, p¢rfusion and IratJsporta¢ion protocols for cryonics, with the empha515 on minimi5ing cellular deterioration, particularly to retain brain integrity and infomiation retention. S¢ptember- Attendcd Emergency Service5 Show at NEC for networking and equiptnent research purwses. Or D Preservatl A Researth Trust Re rt of theTrnstee5 for JI Ilecem r 2022- colltillued December- Hostcd public training day in Sheffield to i¢arh and praGti¢e stabilisation, perfijston wd *nnsP¢Ytation protowls for cryonics. with the emph￿15 on minimising cellular deteriorntion. particularly to retain br8irt in*grity and infotm8tioti retention. De¢etttber Meeiing to brief alternalive independcnt n5¢dI¢￿ servitt provid¢r and discuss Ex)tential deal lo provide professional mcdical 5tsff for ¢ryonics training and live tall-outs. Negotiation5 with initial provider in May f¢ll through. Publi¢ Awarenes5: 58 email enquiries from members of the public. 61 email enquiries from the media. M#y- ItLt¢TYi¢wed for Hisw of Ithverttioos pod¢&8t hosted by Dalla5 Campbell of Th¢ Gad8¢1 Show. Jun¢- lrtiervi¢wed fr)r BBC Radio 4 Listening Project. Broadcast in July 2022. June- Twk part in Channel 4 documentary'Growng Up, with Kthy Burke. Bro8d¢&qt in March 2023. July- Took part in virtual r¢ality filming for stud¢nt documentary. July- lThitial diwjssions with ITN Productiorts resarding BBC Science documentary. August- Tw>k part in pilot d(Kumentary Prod￿Ced by Endemol for Ndftix ¢ntitlcd ImJnort31. Sep¢emberl(ktober- Tc4Jk part in documenlary produc¢d by a student at the National Film Schwl of Denmark. October- Cryoni¢5 UK training r¢c¢iv¢d positive review on the Live Forever Club blog. Re￿rth. March- Cryortics ca%e in Newcastle involving cancer patient. Sign-up completed and deploytnertt of cryonic$ team iniiiatal $imultaneollsly. Fornial emergency assistance agre¢m¢nt used for fit5t titne. Hospitsl procedure plan and powerof attorney documenis proved useful in ensuring smooth co-operation with hospital. Perfusion proved challengtng due to compromised vasculature but ultimately wmpl¢t¢d sU￿¢s5[u11y. Rewsable dry t¢e $hippin8 c&%e used for last lime but will be retRined in case of emergew. MarGh- Cryoni¢s tase in Nottin8ham involving existing Cryonic5 Instiwie aihd Cryi)niG5 UK m¢mb¢T. Death was unexpected and oGcurred in evening. Ambulance seTvÈce and police attended. Polsce agrc¢d to grant ¢ustody of p2tiertt to Cryoni¢s UK and local fuoeral director. Cooling with water ice w&8 perrnitt¢d utLtiI coroDer's input had been sought. After wnsultstion with Cryoni¢s UK and patient'5 doctor in the tnoming, coroner decided lo take no further actiort. No perfusion Undert￿¢￿ but paiietti in dt) ice approximately 24 hour5 after death. C85¢ PTovidedv*luAble experience in dealing with comn¢r ill r¢lation to 8n unexpected death. MaTch-July- T¢sts ¢wried ollt and re$ults presented by Mike Carter in respect of m¢85uring pr¢55UT¢1055 in the perfusion ircuit attd irt parti¢ularacross varying diameters of cannula and at varying perfusat¢ tlow rates. O¢lober- Cryoni¢s case ttt Isle of Man irtvolving existing Cryonics Institute meTnber. Team deployed with several days to Sport 0$ rapid deployment not fe&sible due io ihe offSI￿r¢ lo¢atitsn, As the IOM is att independent jurisdlciion. Ihis presented some legal tsncertainlies, however the legislation largely mirrors LIK IBW. There wL% no readily availAble sourc¢ of dry ice on the island so imporring frorn th¢ rnainland inyolved significant transport costs atld pap¢rwork. Hospital mortuary ollt-of.hou procedur¢5 caus¢d a llolable delay in iniliatin8 patient 51abilisation. how¢verthc local funeral director Jnd regi$itai of birth$ and d¢aths w¢re oxtremely helpfijl ald adaptable. play%ng a significant rol¢ in smoothing out the post-hospitsl elements. Perfusion went well with minor iswes beirtg resolved. The case involved th¢ firsl use cf a bio-seal bag, replacing the Ziegler he Year Ended 31 Iktember 2022. ntinued FebrU￿-NOyember- Seven last minute enquiries for stAndby and ¢ryOPTfseTvation received in respect of potenti￿ patients wilh no existing cryoni¢s 3rrnllg¢m¢nts or significant knowledge. Four of the potenlial cas¢s were outside the UK. Fouraf the pot¢ntial pa12ents were already d¢c¢a5ed. Noneof these ettquiries pro8ressed beyiind phon¢ calls or emails. December- Cryonics case in B&%ift8Stoke involving existing Alcor member and well-krtown ¢ryonics cnthu51a5t. The paiierjt died in h05Pltal followin¥ a short illness. Despite the cryonios atrangemenls being known to the f3mily. Alcor or Cryonics UK wejt not informed and a cremation w8$ ofEani$ed. Howev¢r..41cor becam¢ aware of the $s¢uaiion and Cryonics UK quickly reco￿red the patient for cryopr¢scTvation. Cryoproiective perfv$ion not feasiblc du¢ TO th¢ extended rime sinee deaih. The I￿￿teS have had regard lo the guidance i￿lled by the Charity Comtnissitsn on pvblic benefit and can confimi they hav¢ complicd with their duties ￿nd¢T s¢ction 4 of the 2006 Charities Act. Struttllr ov e and Mang mtn The ¢hOTity is unillwrKX)raled Injst which 1$ governed by a trust deed adopted on 7 December 1990 and 3mend¢d on I January 2021. It was Jrgisler¢d os a ¢hgrity by the Charity Commission for England and WaIes on 31 January 1991. The harrty acts by way of ils coryorate ￿$1¢¢, HOPRT T￿st¢¢ Ltd with wmpany #utnber 11926484. HOPRT Trustee Lid- manag¢d by a board of direciots in ctrllaboration w&th an advisory committee. stsr ofTrusttt$ The appointm¢ni of irustees is mad¢ b). thok ¢xisting as Truste&s. We meet re8uiar]y to review th¢ business of the Charity. Fi#&AeeS The attached financial statcm¢nts show the current state of the finonGes which the board consider to be sound. Restrves Polit To accumulate restrve5 Én orderto fund Iw eqllipment purGh95¢s and res¢&rch projects. Incr¢a%¢ iDvolvemettl of voluttieets. especially younger people, particularly traLnltt8. Improve ¢lYi¢iency of sign up pwKedure, particularly und¢r cm¢rgency circumstances. To iT&in with and utili5e extemal p2r2medic 5¢rvitts. Improve HOPRT'S banking arrangements. Coniillue with upddt¢s of operational documentation. Conclude outstanding ¢quipmcnt development projects. particularly the n¢w ice bath. Continue to explor¢ avenues for raising public awaTeness of cryopreservation Teseèrch and techniques. Research new av¢Du¢$ for improved equipment and tryopre%rvation twhniques. Raise furihet funds to be able 10 afford larger scale research proj¢¢t$. Increase iniemational ¢o-OP¢Talion between cryorJi¢s 8roups, improve Illl¢rnation￿ emergency readiness artd IK)St periodic training event$ around th¢ UK and in Europe. Human O an Pre8erv*tlo rtolt Trustees for ued Referenee Ind Adjxthlsirxtive knforjnitio Admloi$tr¥tiokn: Etuman (hgan Preservation Research Trytst kDown os Cryonir5 UK Correspondenc¢ AddtYS5: 45 St Mary's Road London W5 SRG IndeptndeTrt Examiner. Mr J Liptrott FCA Haines Watts Nottin8ham Limit¢d Chartered Ac¢oJlltsttis Cliffe Hill HotJ5e 22-26 Nottingham Road Stapleford Nottingham NG9 8AA B*nkiDg Address: Natwest Bank Pl l The Mall Ealing London W5 2PL CAF ￿[￿k 25 Kings Hill West Malling Kent ME194JQ Regist¢red Ch4rity Number. 1001750 As a charity. Humart Orw PreseTvatiorJ R¢5¢arch Trust ha5 a wryorate tNs*e that oversees the running of the organisalion. Tn￿le¢. HOPRT Truste¢ Ltd (from 01101120211 optrati￿ N*tht Cryonics UK De¢larntion l th¢ Tru￿¢¢ de¢lar¢ I have approved the Ttwsiees Report above, and am author￿ to sign it their b¢half. rim Gibson FullNamc............................................................... Trusteè 8oard Member Position.. 721C&12024 SignatUT¢.......................... Date Jnd ndent ExamiYLer's Re rt to the Trustees of HurniD Or rt PreservAtiott rch Tr￿st rwn to the Trustees on my examination of the accounts of Human Organ Preservation Research TLUSt for the year ended 31 December 2022. RespoD5ibiliti¢s and b05is of report As th¢ tharity trustees of the Trust you #r¢ r¢$wnsible for the preparation of the accounts in accordance with the r¢quiremens of the Charities Act 2011 I'the Acl'l. I report in respect of my examination of the Trust's accounts carrie5 ou¢ und¢r SectiotL 145 of the 2011 Act attd in carrying out my cxamination I hav¢ followed atl applicable Dir¢ctions given by th¢ Charity Commission under Section 14515Xbl of the Act. Indepelldent Eximiner's StAtement I haN'e compl¢t¢d my examination. I confirm that no materilll rn&ttets have tome 10 my atterttion in connection with the ¢xamin4tion giving me raus¢ lo b¢li¢v¢ th41 in any fflaterial re5pect.'- Accounting records were not kept ifi respect of The Trust as required by Section 130 of the Act. or 2. The accounts th not 8c¢ord with those records. I have no coTrcern5 and hav¢ come acr055 110 oih¢r rnattcrs in conn¢¢tion with the examinAtion to which attention should be drawn in this report in OTderto enRble a prtsper ufjderstartdin8 or the accounts ￿ be reached. Mr J Lipirott FCA CharEered Accountani Haine5 Watts Chartered Accountants Cl&ffe Hill House 22-26 Nottingham Road Stspleford Nottin8ham NG9 8L4 Hum8D O an PreservAtlon ReyeArch Trust Rete tsittdP mtnts Aecoullt tor the YeAr Ettdtd 31 De¢embtr 2022 Restricted Funds 2022 2021 2022 2021 BALANCE BROUGHT FORWA CAF Cash Current Account CAF Gold Deposit AGwunt PayPal A¢wunt Natwesl Busin¢5s Current Account Natwegl Dep05Lt A¢¢ount 50,964.33 0.62 18.92 10.431.38 1000.08 62.415.3J 33.768.35 19.515.76 18.92 53,303.03 RECEIprs Investment incorne {B￿k Int¢r¢5tl 205.37 1.82 Cfrarit4bl¢ Activitics: Prepaid Cryopr¢s¢rvation fimds Subs¢riptions Sal¢ of equipm¢nt Amazorj $￿ile donations Other Income 59,367.80 12.632.20 13.660.00 189.29 24.60 577_55 27,289.01 13.6IE.80 313.26 22.21 21KI.00 14.149.09 59,367.80 PAYMENTS C￿t of ChaTltable Activitiu: R¢turn¢d prepaid funds Cryopreservdtio]J Costs (prepaid) Cryopreseryation costs (not prepaid) Ambulance n>nntn8 Costs Other motorand travel costs Tr￿niThg costs Postage, phorte atsd miscellaneous admin Conswnabl¢s amd ¢quiprn¢nt BOC r¢lltal and refi115 20,313.19 38,431.88 1937.74 2,124.06 893.41 701.01 103.86 1.130.36 1.419.96 1,870.93 384.00 17.81 943.80 1.068.08 369.65 suP￿rt Costs.. Bank charges Insurance ICO fee Professional ftes lac¢ountanll 81.(Kl 444.34 35.00 360.L%J 102.50 254.67 35.00 360.00 62 052.46 93.IK) TOTAL RECEIPTS ILESS PAYMEP4TS) 12,684.661 19.996.01 9.112.30 ARRIED FORWARD 82411.34 62.415.33 REPRESENTED BY: CAF Cash Current Accotsnt CAF Gold Deposit Account PayPal Account Natwest Current A¢count NatW¢st DEPQSit Acwurtt 18.584.45 54.197.28 18.92 5.923.76 1,002.27 79.726.68 50.964.33 0.62 18.92 10,431.38 I.OLN).08 62 415.33 HUMID O n PrtterryAtlon Rtsexrch T temtnt of Assets Li#bilrtits #s #t 2022 2021 RESTRtCTED ED TriRESTiUCTED .45SETS Cash Funds CAF Bank Current Account CAF Bank Dep051t Account PayP81 AccoDnt Natwesi Current AccouTrt Natwest DetM)sit A¢LX)Ullt 18.584.45 54,197.28 18.92 5.923_76 1.002.27 50.964.33 0.62 18.92 10.431.38 1,000.08 79.726.68 62.415.33 ed Assets Ambulan¢¢ LK09 HDF Equipment 10.723.28 10,969.83 10,723.28 10,914.87 THER MONETARY ASSETS Stock 9,101.34 9.585.12 Pre5emtioD R rust r Ended 31 December 2022 Ac¢ountiDg Policies The ac£otsttts Ifinartcial statements} have been PTEpared in a¢¢ordan¢e with Accaunting and Reporting by Charitie5'. Statement of Recommended Practice applicable te charittes pr¢p2ring their ac¢ounts itt a¢¢ord4nG¢ with th¢ FirLan¢ial REPOrting Standard applicable in the and Republic of Ireland (FRS102} issued lrt January 2019. th¢ Finan¢ial R¢FQrting Stsndard applicable in the UK and R¢public of Ireland IFRS1021. and th¢ Charities Act 2011. Th¢ account5 Ifinan¢ial 5tst¢mentsl have been prepared to give & 'true and fair. view and have departed from the Charitie5 (Accounts and R¢pDrts1 RegultitioD5 2008 only to th¢ ¢xt¢nt required to provid¢ a 'tru¢ and fair. view. This departure h&% involved followivg the A4¢ouniing 4ad Reporting by Charit1¢5.' Stat¢ment of R¢¢ommended Practice applicable lo charities preparirtg their accouttts in accordance with th¢ Finsncial Rew)rtirtg StandBrd applicabic in tbc Hnd R¢publi¢ of Ireland {FRS1021 Issued January 2019 rather than the Accountin8 and Reportujg by Cltariti¢s'. Stst¢m¢nt of RKOMM¢nd￿ Practice effective from l April 2005 which h8$ since b¢¢n wrthdrnwn. a) Income This is ac¢ount¢d fori)n a rxeiyable basi5 in the period in which it LS recelved. bl P•yrn¢ryts Th¢s¢ are ac¢ounted for 18 paid. The charity meets the definition of a public b2nefLtentity under FRSIO2. The Tru5tee5 consider there are no materia] un¢ert*inties about Ihe charity's ability lo ¢otttinue as a 8OtiJ8 ton¢em. The acwuDts ar¢ pres¢nt¢d tD St¢rling £. Trn$te¢ Expenses The followin8 expeDses wert reimbutsed in this yeat. Suspension expen5e¥ IT¢imbur5ed costs otlly) NIL NIL Atty balance of expeLses was paid to voluntetrs br suspeTJSiOn 2nd equipment Costs incvrr¢d in rarryingout the chgrity's aciivitÈes. There are no other related party transactions to note. Trustees. Remuuer#tioD No remuneration oremolumejts were received by Ille Tnkstees either irt th¢ir capacity Ls Trusttts or a% Tnember5 of th¢ Board of TTUStees aod no emolum¢nts paid in exc¢ss of £60,000. Th¢ cllarity 1$ regi5t¢red as a¢harity aThd suth not&xation 15 payablcon the ¢xccss of inwm¢ ov¢r expcnditur¢.